BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51077165 Nc1nc(Nc2ccc(cc2)S(=O)(=O)NCCO)nc(OCC2CCCCC2)c1[N+](=O)[N-]C#N InChI=1S/C20H26N8O5S/c21-13-23-28(30)17-18(22)26-20(27-19(17)33-12-14-4-2-1-3-5-14)25-15-6-8-16(9-7-15)34(31,32)24-10-11-29/h6-9,14,24,29H,1-5,10-12H2,(H3,22,25,26,27)/b28-23- LWXURRMEKPTBNZ-NFFVHWSESA-N 50440473 CHEMBL2425904 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 875 ChEMBL 10.1016/j.ejmech.2013.07.031 10.7270/Q2ZW1NB0 23994326 Boschi, D; Tosco, P; Chandra, N; Chaurasia, S; Fruttero, R; Griffin, R; Wang, LZ; Gasco, A Universit£ degli Studi di Torino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440473&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72708421 175452790 CHEMBL2425904 ZINC96284200 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51077166 CNS(=O)(=O)c1ccc(Nc2nc(N)c(c(OCC3CCCCC3)n2)[N+](=O)[N-]C#N)cc1 InChI=1S/C19H24N8O4S/c1-22-32(29,30)15-9-7-14(8-10-15)24-19-25-17(21)16(27(28)23-12-20)18(26-19)31-11-13-5-3-2-4-6-13/h7-10,13,22H,2-6,11H2,1H3,(H3,21,24,25,26)/b27-23- KRCMSHILTUKGTA-VYIQYICTSA-N 50440474 CHEMBL2425903 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1660 ChEMBL 10.1016/j.ejmech.2013.07.031 10.7270/Q2ZW1NB0 23994326 Boschi, D; Tosco, P; Chandra, N; Chaurasia, S; Fruttero, R; Griffin, R; Wang, LZ; Gasco, A Universit£ degli Studi di Torino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440474&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72708420 175452791 CHEMBL2425903 ZINC96284201 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036791 Cc1nc2CCc3cnc(Nc4cccc(c4)[N+]([O-])=O)nc3-c2s1 InChI=1S/C16H13N5O2S/c1-9-18-13-6-5-10-8-17-16(20-14(10)15(13)24-9)19-11-3-2-4-12(7-11)21(22)23/h2-4,7-8H,5-6H2,1H3,(H,17,19,20) ZLHUAMTYKCRXDR-UHFFFAOYSA-N 50423753 CHEMBL601064 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423753&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11163580 164152628 CHEMBL601064 ZINC06744721 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036792 Nc1nc2CCc3cnc(Nc4cccc(c4)[N+]([O-])=O)nc3-c2s1 InChI=1S/C15H12N6O2S/c16-14-19-11-5-4-8-7-17-15(20-12(8)13(11)24-14)18-9-2-1-3-10(6-9)21(22)23/h1-3,6-7H,4-5H2,(H2,16,19)(H,17,18,20) YARIHEYYGBAEDE-UHFFFAOYSA-N 50423754 CHEMBL598992 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423754&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11233090 164152629 CHEMBL598992 ZINC45366264 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036795 Cc1nc2CCc3cnc(Nc4cccc(O)c4)nc3-c2s1 InChI=1S/C16H14N4OS/c1-9-18-13-6-5-10-8-17-16(20-14(10)15(13)22-9)19-11-3-2-4-12(21)7-11/h2-4,7-8,21H,5-6H2,1H3,(H,17,19,20) BHDMRJQKCJHJGQ-UHFFFAOYSA-N 50423756 CHEMBL611995 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423756&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11289869 164152631 CHEMBL611995 ZINC06744724 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036800 Nc1nc2CCc3cnc(Nc4ccccc4)nc3-c2s1 InChI=1S/C15H13N5S/c16-14-19-11-7-6-9-8-17-15(20-12(9)13(11)21-14)18-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,16,19)(H,17,18,20) KVWXCLSLVYUBDG-UHFFFAOYSA-N 50423760 CHEMBL599804 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423760&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11266412 164152635 CHEMBL599804 ZINC45368864 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036801 Cc1nc2CCc3cnc(Nc4ccc(cc4)[N+]([O-])=O)nc3-c2s1 InChI=1S/C16H13N5O2S/c1-9-18-13-7-2-10-8-17-16(20-14(10)15(13)24-9)19-11-3-5-12(6-4-11)21(22)23/h3-6,8H,2,7H2,1H3,(H,17,19,20) QSFSXNZWOUTZCW-UHFFFAOYSA-N 50423761 CHEMBL599806 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423761&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 45140949 164152636 CHEMBL599806 ZINC45368867 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036803 CN(C)c1ccc(Nc2ncc3CCc4nc(N)sc4-c3n2)cc1 InChI=1S/C17H18N6S/c1-23(2)12-6-4-11(5-7-12)20-17-19-9-10-3-8-13-15(14(10)22-17)24-16(18)21-13/h4-7,9H,3,8H2,1-2H3,(H2,18,21)(H,19,20,22) UURXVIAFQIYUCN-UHFFFAOYSA-N 50423759 CHEMBL598166 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423759&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 45140951 164152634 CHEMBL598166 ZINC53193347 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036805 Cc1nc2CCc3cnc(Nc4ccccc4)nc3-c2s1 InChI=1S/C16H14N4S/c1-10-18-13-8-7-11-9-17-16(20-14(11)15(13)21-10)19-12-5-3-2-4-6-12/h2-6,9H,7-8H2,1H3,(H,17,19,20) XGCZPWOZBDACQN-UHFFFAOYSA-N 50423763 CHEMBL601705 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423763&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11150562 164152638 CHEMBL601705 ZINC38304257 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036810 Cc1nc2CCc3cnc(Nc4ccc(O)cc4)nc3-c2s1 InChI=1S/C16H14N4OS/c1-9-18-13-7-2-10-8-17-16(20-14(10)15(13)22-9)19-11-3-5-12(21)6-4-11/h3-6,8,21H,2,7H2,1H3,(H,17,19,20) UZIOINNWQLHWHQ-UHFFFAOYSA-N 50423762 CHEMBL605635 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 490 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423762&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11266891 164152637 CHEMBL605635 ZINC06744727 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036813 CN(C)c1ccc(Nc2ncc3CCc4nc(C)sc4-c3n2)cc1 InChI=1S/C18H19N5S/c1-11-20-15-9-4-12-10-19-18(22-16(12)17(15)24-11)21-13-5-7-14(8-6-13)23(2)3/h5-8,10H,4,9H2,1-3H3,(H,19,21,22) LQAKEBHLLHQRTR-UHFFFAOYSA-N 50423757 CHEMBL609915 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 640 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423757&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11163528 164152632 CHEMBL609915 ZINC06744728 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036814 Cc1nc2CCc3cnc(Nc4ccc(cc4)N4CCOCC4)nc3-c2s1 InChI=1S/C20H21N5OS/c1-13-22-17-7-2-14-12-21-20(24-18(14)19(17)27-13)23-15-3-5-16(6-4-15)25-8-10-26-11-9-25/h3-6,12H,2,7-11H2,1H3,(H,21,23,24) CZKOEIIINXNUJD-UHFFFAOYSA-N 50423764 CHEMBL598993 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 640 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423764&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11199830 164152639 CHEMBL598993 ZINC06744726 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036815 COC(=O)c1ccc(Nc2ncc3CCc4nc(C)sc4-c3n2)cc1 InChI=1S/C18H16N4O2S/c1-10-20-14-8-5-12-9-19-18(22-15(12)16(14)25-10)21-13-6-3-11(4-7-13)17(23)24-2/h3-4,6-7,9H,5,8H2,1-2H3,(H,19,21,22) SXTFKTKGQZLIBF-UHFFFAOYSA-N 50423765 CHEMBL601088 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 670 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423765&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 45140950 164152640 CHEMBL601088 ZINC45368241 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036821 COc1ccc(Nc2ncc3CCc4nc(C)sc4-c3n2)cn1 InChI=1S/C16H15N5OS/c1-9-19-12-5-3-10-7-18-16(21-14(10)15(12)23-9)20-11-4-6-13(22-2)17-8-11/h4,6-8H,3,5H2,1-2H3,(H,18,20,21) JILRFQCHFBJCKL-UHFFFAOYSA-N 50423758 CHEMBL598994 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423758&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11381775 164152633 CHEMBL598994 ZINC06744731 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036824 Cc1nc2CCc3cnc(Nc4ccc(Cl)nc4)nc3-c2s1 InChI=1S/C15H12ClN5S/c1-8-19-11-4-2-9-6-18-15(21-13(9)14(11)22-8)20-10-3-5-12(16)17-7-10/h3,5-7H,2,4H2,1H3,(H,18,20,21) ANWMSXOBKGKAOJ-UHFFFAOYSA-N 50423755 CHEMBL609322 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1200 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423755&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11198278 164152630 CHEMBL609322 ZINC06744730 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036828 Cc1nc2CCc3cnc(Nc4ccc(cc4)C(F)(F)F)nc3-c2s1 InChI=1S/C17H13F3N4S/c1-9-22-13-7-2-10-8-21-16(24-14(10)15(13)25-9)23-12-5-3-11(4-6-12)17(18,19)20/h3-6,8H,2,7H2,1H3,(H,21,23,24) BFOWMTATJFCJBB-UHFFFAOYSA-N 50423766 CHEMBL599805 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1900 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423766&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11428427 164152641 CHEMBL599805 ZINC06744723 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036835 CN(c1cccc(c1)[N+]([O-])=O)c1ncc2CCc3nc(C)sc3-c2n1 InChI=1S/C17H15N5O2S/c1-10-19-14-7-6-11-9-18-17(20-15(11)16(14)25-10)21(2)12-4-3-5-13(8-12)22(23)24/h3-5,8-9H,6-7H2,1-2H3 VWRLUJJMDMLBIF-UHFFFAOYSA-N 50423768 CHEMBL606176 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423768&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11451037 164152643 CHEMBL606176 ZINC45392226 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036840 Cc1nc2CCc3cnc(N)nc3-c2s1 InChI=1S/C10H10N4S/c1-5-13-7-3-2-6-4-12-10(11)14-8(6)9(7)15-5/h4H,2-3H2,1H3,(H2,11,12,14) ZPMLSCOIBKNXNK-UHFFFAOYSA-N 50423770 CHEMBL611074 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423770&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11287415 164152645 CHEMBL611074 ZINC45394377 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036842 CN(c1cccc(c1)[N+]([O-])=O)c1ncc2ccc3nc(C)sc3c2n1 InChI=1S/C17H13N5O2S/c1-10-19-14-7-6-11-9-18-17(20-15(11)16(14)25-10)21(2)12-4-3-5-13(8-12)22(23)24/h3-9H,1-2H3 BUBBOLABRKMKTQ-UHFFFAOYSA-N 50423769 CHEMBL597359 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423769&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11268167 164152644 CHEMBL597359 ZINC34434225 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036844 Cc1nc2ccc3cnc(Nc4ccccc4)nc3c2s1 InChI=1S/C16H12N4S/c1-10-18-13-8-7-11-9-17-16(20-14(11)15(13)21-10)19-12-5-3-2-4-6-12/h2-9H,1H3,(H,17,19,20) DZTKJPVNRWPJLO-UHFFFAOYSA-N 50423767 CHEMBL591228 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423767&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11346863 164152642 CHEMBL591228 ZINC45337705 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036847 Cc1nc2ccc3cnc(NC(=O)c4ccccc4)nc3c2s1 InChI=1S/C17H12N4OS/c1-10-19-13-8-7-12-9-18-17(20-14(12)15(13)23-10)21-16(22)11-5-3-2-4-6-11/h2-9H,1H3,(H,18,20,21,22) WFIWNOLZWKHKDY-UHFFFAOYSA-N 50423771 CHEMBL602746 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423771&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46233557 164152646 CHEMBL602746 ZINC45369807 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51036850 Cc1nc2ccc3cnc(NCc4ccccc4)nc3c2s1 InChI=1S/C17H14N4S/c1-11-20-14-8-7-13-10-19-17(21-15(13)16(14)22-11)18-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,18,19,21) HFSDYNSZXRTUSU-UHFFFAOYSA-N 50423772 CHEMBL596953 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423772&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46233558 164152647 CHEMBL596953 ZINC45356319 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057468 CC[C@H](CO)Nc1nc(NCc2cc(F)ccc2O)c2ncn(C(C)C)c2n1 InChI=1S/C19H25FN6O2/c1-4-14(9-27)23-19-24-17(16-18(25-19)26(10-22-16)11(2)3)21-8-12-7-13(20)5-6-15(12)28/h5-7,10-11,14,27-28H,4,8-9H2,1-3H3,(H2,21,23,24,25)/t14-/m1/s1 MKNHQUCYYAXXMU-CQSZACIVSA-N 50431282 CHEMBL2347578 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 106 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431282&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579251 164160157 CHEMBL2347578 ZINC95605285 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057469 CC[C@@H](Nc1nc(NCc2cc(F)ccc2O)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C20H27FN6O2/c1-5-15(12(4)28)24-20-25-18(17-19(26-20)27(10-23-17)11(2)3)22-9-13-8-14(21)6-7-16(13)29/h6-8,10-12,15,28-29H,5,9H2,1-4H3,(H2,22,24,25,26)/t12?,15-/m1/s1 IJWWOTCVYMBYJL-WPZCJLIBSA-N 50431283 CHEMBL2347577 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431283&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579250 164160158 CHEMBL2347577 ZINC95603314 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057470 CC[C@@H](Nc1nc(NCc2cc(Cl)ccc2O)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C20H27ClN6O2/c1-5-15(12(4)28)24-20-25-18(17-19(26-20)27(10-23-17)11(2)3)22-9-13-8-14(21)6-7-16(13)29/h6-8,10-12,15,28-29H,5,9H2,1-4H3,(H2,22,24,25,26)/t12?,15-/m1/s1 FKSQALHWIWYQJQ-WPZCJLIBSA-N 50431284 CHEMBL2347575 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 165 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431284&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579248 164160159 CHEMBL2347575 ZINC95605588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057471 CC[C@H](CO)Nc1nc(NCc2cc(Cl)ccc2O)c2ncn(C(C)C)c2n1 InChI=1S/C19H25ClN6O2/c1-4-14(9-27)23-19-24-17(16-18(25-19)26(10-22-16)11(2)3)21-8-12-7-13(20)5-6-15(12)28/h5-7,10-11,14,27-28H,4,8-9H2,1-3H3,(H2,21,23,24,25)/t14-/m1/s1 VBYLRWCIAPQRFW-CQSZACIVSA-N 50431285 CHEMBL2349194 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 285 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431285&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579160 164160160 CHEMBL2349194 ZINC95605075 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057472 CC(C)n1cnc2c(NCc3cc(Cl)ccc3O)nc(NC3CCC(N)CC3)nc12 InChI=1S/C21H28ClN7O/c1-12(2)29-11-25-18-19(24-10-13-9-14(22)3-8-17(13)30)27-21(28-20(18)29)26-16-6-4-15(23)5-7-16/h3,8-9,11-12,15-16,30H,4-7,10,23H2,1-2H3,(H2,24,26,27,28) HZNHFNRGJQRTTG-UHFFFAOYSA-N 50431286 CHEMBL2349193 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431286&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49838820 164160161 CHEMBL2349193 ZINC95602807 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057473 CC(C)n1cnc2c(NCc3cc(Cl)ccc3O)nc(NC3CCC(O)CC3)nc12 InChI=1S/C21H27ClN6O2/c1-12(2)28-11-24-18-19(23-10-13-9-14(22)3-8-17(13)30)26-21(27-20(18)28)25-15-4-6-16(29)7-5-15/h3,8-9,11-12,15-16,29-30H,4-7,10H2,1-2H3,(H2,23,25,26,27) CKBQQVRNWKMAPJ-UHFFFAOYSA-N 50431287 CHEMBL2349192 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 910 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431287&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579159 164160162 CHEMBL2349192 ZINC95603478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057474 CC(C)CNc1nc(NCc2ccccc2O)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-12(2)9-21-19-23-17(20-10-14-7-5-6-8-15(14)26)16-18(24-19)25(11-22-16)13(3)4/h5-8,11-13,26H,9-10H2,1-4H3,(H2,20,21,23,24) TVPWWXIFYWANPJ-UHFFFAOYSA-N 50431288 CHEMBL2347584 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3130 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431288&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579077 164160163 CHEMBL2347584 ZINC95601852 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057475 CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCC(C)(C)O)nc12 InChI=1S/C20H28N6O2/c1-13(2)26-12-23-16-17(22-11-14-7-5-6-8-15(14)27)24-19(25-18(16)26)21-10-9-20(3,4)28/h5-8,12-13,27-28H,9-11H2,1-4H3,(H2,21,22,24,25) IXTWXNBAVMLHDT-UHFFFAOYSA-N 50431289 CHEMBL2347583 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431289&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579076 164160164 CHEMBL2347583 ZINC95602155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057476 CC(C)[C@H](Nc1nc(NCc2ccccc2N)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C22H33N7O/c1-13(2)18(22(5,6)30)26-21-27-19(24-11-15-9-7-8-10-16(15)23)17-20(28-21)29(12-25-17)14(3)4/h7-10,12-14,18,30H,11,23H2,1-6H3,(H2,24,26,27,28)/t18-/m0/s1 PKDDEKWAXOEWTM-SFHVURJKSA-N 50431290 CHEMBL2347582 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 845 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431290&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71579075 164160165 CHEMBL2347582 ZINC95603482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057477 CC(C)n1cnc2c(NCc3ccccc3N)nc(NCCC(C)(C)O)nc12 InChI=1S/C20H29N7O/c1-13(2)27-12-24-16-17(23-11-14-7-5-6-8-15(14)21)25-19(26-18(16)27)22-10-9-20(3,4)28/h5-8,12-13,28H,9-11,21H2,1-4H3,(H2,22,23,25,26) DDRXYGOUYIHOPA-UHFFFAOYSA-N 50431291 CHEMBL2347581 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431291&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 67002844 164160166 CHEMBL2347581 ZINC95601521 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057478 CC(C)n1cnc2c(NCc3ccccc3N)nc(NCC(C)(C)O)nc12 InChI=1S/C19H27N7O/c1-12(2)26-11-23-15-16(21-9-13-7-5-6-8-14(13)20)24-18(25-17(15)26)22-10-19(3,4)27/h5-8,11-12,27H,9-10,20H2,1-4H3,(H2,21,22,24,25) DCHDOYXSTZNERE-UHFFFAOYSA-N 50431292 CHEMBL2347580 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1240 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431292&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926801 164160167 CHEMBL2347580 ZINC68243806 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057479 CC[C@H](CO)Nc1nc(NCc2ccccc2O)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)/t14-/m1/s1 NDUVSANREQEDRE-CQSZACIVSA-N 50366800 OLOMOUCINE II Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 815 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366800&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CK9 2A0C 5494414 160845902 DB04662 ZINC12504456 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51057480 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2694 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 13641 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 8061 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32::4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidin-2-amine, 4::4-methyl-5-{2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1,3-thiazol-2-amine::CDK Inhibitor, 1::[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.012 10.7270/Q2CJ8BPP 15261277 aid1796133 Wang, S; Wood, G; Meades, C; Griffiths, G; Midgley, C; McNae, I; McInnes, C; Anderson, S; Jackson, W; Mezna, M; Yuill, R; Walkinshaw, M; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8061&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1PXO,2WEV 447961 11108815 C06058 ZINC02047389 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 21693 Nc1n[nH]c(N)c1\N=N\c1ccccc1 InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+ BLXRKDXUWQFGAW-OUKQBFOZSA-N 12024 4-Arylazo-3,5-diamino-1H-pyrazole 1b::4-[(E)-2-phenyldiazen-1-yl]-1H-pyrazole-3,5-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12024&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5284904 46512531 ZINC17312777 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 21694 Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+ IXYLIAXCCAHPJQ-OUKQBFOZSA-N 12025 4-Arylazo-3,5-diamino-1H-pyrazole 26b::4-[(E)-2-(2-nitrophenyl)diazen-1-yl]-1H-pyrazole-3,5-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5600 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12025&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11673204 46512532 ZINC14949079 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 21695 Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+ KNSDLOIIFWEGLS-OUKQBFOZSA-N 12026 4-Arylazo-3,5-diamino-1H-pyrazole 27b::4-[(E)-2-(3-nitrophenyl)diazen-1-yl]-1H-pyrazole-3,5-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12400 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12026&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 10214593 46512533 ZINC14949084 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 21696 Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+ WELGNMVJTNYIRH-OUKQBFOZSA-N 12027 3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol::4-Arylazo-3,5-diamino-1H-pyrazole 30b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12027&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 9964499 46512534 ZINC14949086 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 21697 Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15) AYZRKFOEZQBUEA-UHFFFAOYSA-N 12028 4-Arylazo-3,5-diamino-1H-pyrazole 31b::4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol::CAN508 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12028&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search F18 3TN8,3TNH,3TNW,2CLX 9859248 46512535 ZINC17782150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 21698 Nc1n[nH]c(N)c1\N=N\c1ccccc1CO InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+ LOTUARPYXHNGEY-BUHFOSPRSA-N 12029 4-Arylazo-3,5-diamino-1H-pyrazole 35b::{2-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenyl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12029&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 10308009 46512536 ZINC14949090 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 49955 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 49956 CC[C@H](CO)Nc1nc(NCc2ccccc2)n2ncc(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-18-23-17-16(13(2)3)11-21-25(17)19(24-18)20-10-14-8-6-5-7-9-14/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 SQUNOCMDMIQIQK-OAHLLOKOSA-N 27217 (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol::GP0210::pyrazolo[1,5-a]-1,3,5-triazine, 7a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search NNN 3DOG 25190761 57298927 DB08285 ZINC34285231 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 49957 CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)n2ncc(C(C)C)c2n1 InChI=1S/C19H25ClN6O/c1-11(2)15-9-21-26-17(15)24-18(23-16(10-27)12(3)4)25-19(26)22-14-7-5-6-13(20)8-14/h5-9,11-12,16,27H,10H2,1-4H3,(H2,22,23,24,25)/t16-/m0/s1 XCRSLBLUJPTVDN-INIZCTEOSA-N 27218 (2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl}amino)-3-methylbutan-1-ol::pyrazolo[1,5-a]-1,3,5-triazine, 7c Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27218&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25190762 57298928 ZINC42187870 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 49958 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 ITFLOJJAVYXCTM-OAHLLOKOSA-N 27219 (2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,2-a][1,2,4]triazin-2-yl]amino}butan-1-ol::(2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[2,1-f][1,2,4]triazin-2-yl]amino}butan-1-ol::imidazo[2,1-f]-1,2,4-triazine, 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27219&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25190763 57298929 ZINC40413302 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50170 Nc1nccc(n1)-c1cc2c([nH]1)[C@H](CCF)CNC2=O InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m1/s1 LCBAQTCTQXHTJG-SSDOTTSWSA-N 27379 (7R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::Pyrrolopyridinone, 89R Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96 Curated from the literature by BindingDB 10.1021/jm800977q 10.7270/Q27W69JX 19115845 aid1798799 Menichincheri, M; Bargiotti, A; Berthelsen, J; Bertrand, JA; Bossi, R; Ciavolella, A; Cirla, A; Cristiani, C; Croci, V; D'Alessio, R; Fasolini, M; Fiorentini, F; Forte, B; Isacchi, A; Martina, K; Molinari, A; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pezzetta, D; Pillan, A; Poggesi, I; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Volpi, D; Santocanale, C; Vanotti, E Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27379&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25190896 57299088 ZINC40380089 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50171 Nc1nccc(n1)-c1cc2c([nH]1)[C@@H](CCF)CNC2=O InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m0/s1 LCBAQTCTQXHTJG-ZETCQYMHSA-N 27380 (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::Pyrrolopyridinone, 89S Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28 Curated from the literature by BindingDB 10.1021/jm800977q 10.7270/Q27W69JX 19115845 aid1798799 Menichincheri, M; Bargiotti, A; Berthelsen, J; Bertrand, JA; Bossi, R; Ciavolella, A; Cirla, A; Cristiani, C; Croci, V; D'Alessio, R; Fasolini, M; Fiorentini, F; Forte, B; Isacchi, A; Martina, K; Molinari, A; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pezzetta, D; Pillan, A; Poggesi, I; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Volpi, D; Santocanale, C; Vanotti, E Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27380&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 553 3DU8 16757525 57299089 DB07149 ZINC39144346 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 256108 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H27ClFN5/c25-21-15-29-24(30-19-9-7-16(13-27)8-10-19)12-20(21)22-5-2-6-23(31-22)28-14-17-3-1-4-18(26)11-17/h1-6,11-12,15-16,19H,7-10,13-14,27H2,(H,28,31)(H,29,30)/t16-,19- PKEKPWJQRZLOPO-RUCARUNLSA-N 126191 US8778951, 1 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126191&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 60142134 225152552 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256109 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCNCC3)ncc2Cl)c1 InChI=1S/C22H23ClFN5/c23-19-14-27-22(28-17-7-9-25-10-8-17)12-18(19)20-5-2-6-21(29-20)26-13-15-3-1-4-16(24)11-15/h1-6,11-12,14,17,25H,7-10,13H2,(H,26,29)(H,27,28) PXPAHPCLBJKTEW-UHFFFAOYSA-N 126192 US8778951, 2 Cyclin-T1 Homo sapiens 0.025572 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126192&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 60142135 225152553 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256110 CCS(=O)(=O)N1CCC(CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H27ClFN5O2S/c1-2-34(32,33)31-11-9-19(10-12-31)29-24-14-20(21(25)16-28-24)22-7-4-8-23(30-22)27-15-17-5-3-6-18(26)13-17/h3-8,13-14,16,19H,2,9-12,15H2,1H3,(H,27,30)(H,28,29) TZNKIGIHGJZECV-UHFFFAOYSA-N 126193 US8778951, 3 Cyclin-T1 Homo sapiens 0.237603 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126193&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936847 225152554 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256111 CN(C)CC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C27H32ClFN6O/c1-35(2)17-27(36)33-21-11-9-20(10-12-21)32-26-14-22(23(28)16-31-26)24-7-4-8-25(34-24)30-15-18-5-3-6-19(29)13-18/h3-8,13-14,16,20-21H,9-12,15,17H2,1-2H3,(H,30,34)(H,31,32)(H,33,36)/t20-,21- RAUVMPWJQFAQSW-MEMLXQNLSA-N 126194 US8778951, 4 Cyclin-T1 Homo sapiens 0.009055 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126194&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936913 225152555 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256112 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC2CCNCC2)n1 InChI=1S/C21H28ClN5O/c22-18-13-24-21(26-14-4-6-16(28)7-5-14)12-17(18)19-2-1-3-20(27-19)25-15-8-10-23-11-9-15/h1-3,12-16,23,28H,4-11H2,(H,24,26)(H,25,27)/t14-,16- SFZGKYVLHXQPIX-KOMQPUFPSA-N 126195 US8778951, 5 Cyclin-T1 Homo sapiens 0.039655 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126195&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936992 225152556 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256113 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(OCc2cccc(F)c2)n1 InChI=1S/C24H26ClFN4O/c25-21-14-28-23(29-19-9-7-16(13-27)8-10-19)12-20(21)22-5-2-6-24(30-22)31-15-17-3-1-4-18(26)11-17/h1-6,11-12,14,16,19H,7-10,13,15,27H2,(H,28,29)/t16-,19- KITARBPGTZBVEL-RUCARUNLSA-N 126196 US8778951, 6 Cyclin-T1 Homo sapiens 0.136417 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126196&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937029 225152557 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256114 Fc1cccc(CNc2cncc(n2)-c2ccnc(N[C@H]3CC[C@@H](CC3)NCc3ccccc3)c2)c1 InChI=1S/C29H31FN6/c30-24-8-4-7-22(15-24)18-34-29-20-31-19-27(36-29)23-13-14-32-28(16-23)35-26-11-9-25(10-12-26)33-17-21-5-2-1-3-6-21/h1-8,13-16,19-20,25-26,33H,9-12,17-18H2,(H,32,35)(H,34,36)/t25-,26- LUSWQEDEZVKPHS-DIVCQZSQSA-N 126197 US8778951, 7 Cyclin-T1 Homo sapiens 0.024792 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126197&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936934 225152558 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256115 N[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1cc(cc(NCc2cccc(F)c2)n1)C(F)(F)F InChI=1S/C24H25F4N5/c25-18-3-1-2-15(10-18)14-31-23-13-17(24(26,27)28)12-21(33-23)16-8-9-30-22(11-16)32-20-6-4-19(29)5-7-20/h1-3,8-13,19-20H,4-7,14,29H2,(H,30,32)(H,31,33)/t19-,20- YVCYTZSIYSZFBW-MXVIHJGJSA-N 126198 US8778951, 8 Cyclin-T1 Homo sapiens 0.084843 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126198&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937000 225152559 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256116 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClF2N5/c24-19-13-28-22(30-17-6-4-16(27)5-7-17)11-18(19)21-9-8-20(26)23(31-21)29-12-14-2-1-3-15(25)10-14/h1-3,8-11,13,16-17H,4-7,12,27H2,(H,28,30)(H,29,31)/t16-,17- SVUBSMHXRRJCSH-QAQDUYKDSA-N 126199 US8778951, 9 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126199&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936965 225152560 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256117 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(N)c(NCc2cccc(F)c2)n1 InChI=1S/C23H26ClFN6/c24-19-13-28-22(30-17-6-4-16(26)5-7-17)11-18(19)21-9-8-20(27)23(31-21)29-12-14-2-1-3-15(25)10-14/h1-3,8-11,13,16-17H,4-7,12,26-27H2,(H,28,30)(H,29,31)/t16-,17- WOGARJHWDVFAEE-QAQDUYKDSA-N 126200 US8778951, 10::US8778951, 137 Cyclin-T1 Homo sapiens 0.018574 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126200&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405063 225152561 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256118 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(C(N)=O)c(NCc2cccc(F)c2)n1 InChI=1S/C24H26ClFN6O/c25-20-13-29-22(31-17-6-4-16(27)5-7-17)11-19(20)21-9-8-18(23(28)33)24(32-21)30-12-14-2-1-3-15(26)10-14/h1-3,8-11,13,16-17H,4-7,12,27H2,(H2,28,33)(H,29,31)(H,30,32)/t16-,17- ZMZAKBCAMLVUNN-QAQDUYKDSA-N 126201 US8778951, 11 Cyclin-T1 Homo sapiens 0.132509 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126201&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937219 225152562 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256119 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cc(cc(NCc2cccc(F)c2)n1)C#N InChI=1S/C24H24ClFN6/c25-21-14-30-24(31-19-6-4-18(28)5-7-19)11-20(21)22-9-16(12-27)10-23(32-22)29-13-15-2-1-3-17(26)8-15/h1-3,8-11,14,18-19H,4-7,13,28H2,(H,29,32)(H,30,31)/t18-,19- ZGLWMDIDMGZAHZ-WGSAOQKQSA-N 126202 US8778951, 12 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126202&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937194 225152563 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256120 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cc(cc(NCc2cccc(F)c2)n1)C(N)=O InChI=1S/C24H26ClFN6O/c25-20-13-30-23(31-18-6-4-17(27)5-7-18)11-19(20)21-9-15(24(28)33)10-22(32-21)29-12-14-2-1-3-16(26)8-14/h1-3,8-11,13,17-18H,4-7,12,27H2,(H2,28,33)(H,29,32)(H,30,31)/t17-,18- WWVQLIDDZJGLTP-IYARVYRRSA-N 126203 US8778951, 13 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126203&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937229 225152564 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256121 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cc(cc(NCc2cccc(F)c2)n1)C(O)=O InChI=1S/C24H25ClFN5O2/c25-20-13-29-23(30-18-6-4-17(27)5-7-18)11-19(20)21-9-15(24(32)33)10-22(31-21)28-12-14-2-1-3-16(26)8-14/h1-3,8-11,13,17-18H,4-7,12,27H2,(H,28,31)(H,29,30)(H,32,33)/t17-,18- PKNWSZOBHNMVKO-IYARVYRRSA-N 126204 US8778951, 14 Cyclin-T1 Homo sapiens 0.522 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126204&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937174 225152565 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256122 CN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5/c1-32(2)20-11-9-19(10-12-20)30-25-14-21(22(26)16-29-25)23-7-4-8-24(31-23)28-15-17-5-3-6-18(27)13-17/h3-8,13-14,16,19-20H,9-12,15H2,1-2H3,(H,28,31)(H,29,30)/t19-,20- NFXMNCJEQDESFS-MXVIHJGJSA-N 126205 US8778951, 15 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126205&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906614 225152566 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256123 OCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5O/c26-22-16-30-25(31-20-9-7-19(8-10-20)28-11-12-33)14-21(22)23-5-2-6-24(32-23)29-15-17-3-1-4-18(27)13-17/h1-6,13-14,16,19-20,28,33H,7-12,15H2,(H,29,32)(H,30,31)/t19-,20- QYAZVWLXYISNJV-MXVIHJGJSA-N 126206 US8778951, 16 Cyclin-T1 Homo sapiens 0.023617 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126206&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907647 225152567 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256124 CS(=O)(=O)CCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C26H31ClFN5O2S/c1-36(34,35)13-12-29-20-8-10-21(11-9-20)32-26-15-22(23(27)17-31-26)24-6-3-7-25(33-24)30-16-18-4-2-5-19(28)14-18/h2-7,14-15,17,20-21,29H,8-13,16H2,1H3,(H,30,33)(H,31,32)/t20-,21- ZEXUCLNSSZCDPU-MEMLXQNLSA-N 126207 US8778951, 17 Cyclin-T1 Homo sapiens 0.02323424 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126207&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936914 225152568 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256125 CN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H27ClFN5/c1-27-18-8-10-19(11-9-18)30-24-13-20(21(25)15-29-24)22-6-3-7-23(31-22)28-14-16-4-2-5-17(26)12-16/h2-7,12-13,15,18-19,27H,8-11,14H2,1H3,(H,28,31)(H,29,30)/t18-,19- GPDLUBYGZKEYRZ-WGSAOQKQSA-N 126208 US8778951, 18 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126208&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936924 225152569 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256126 CNC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5/c1-28-14-17-8-10-20(11-9-17)31-25-13-21(22(26)16-30-25)23-6-3-7-24(32-23)29-15-18-4-2-5-19(27)12-18/h2-7,12-13,16-17,20,28H,8-11,14-15H2,1H3,(H,29,32)(H,30,31)/t17-,20- QTSXBCPWABOXHQ-IRJFHVNHSA-N 126209 US8778951, 19 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126209&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937109 225152570 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256127 Fc1cc(F)cc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@@H](CC3)N3CCCC3)ncc2Cl)c1 InChI=1S/C27H30ClF2N5/c28-24-17-32-27(33-21-6-8-22(9-7-21)35-10-1-2-11-35)15-23(24)25-4-3-5-26(34-25)31-16-18-12-19(29)14-20(30)13-18/h3-5,12-15,17,21-22H,1-2,6-11,16H2,(H,31,34)(H,32,33)/t21-,22- WXYUZDXUSIASKF-HZCBDIJESA-N 126210 US8778951, 20 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126210&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937020 225152571 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256128 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCCCC2)n1 InChI=1S/C23H32ClN5/c24-20-15-27-23(28-18-11-9-17(25)10-12-18)13-19(20)21-7-4-8-22(29-21)26-14-16-5-2-1-3-6-16/h4,7-8,13,15-18H,1-3,5-6,9-12,14,25H2,(H,26,29)(H,27,28)/t17-,18- UTEWJTHBWDYHHQ-IYARVYRRSA-N 126211 US8778951, 21 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126211&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794013 225152572 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256129 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccccc2)n1 InChI=1S/C23H26ClN5/c24-20-15-27-23(28-18-11-9-17(25)10-12-18)13-19(20)21-7-4-8-22(29-21)26-14-16-5-2-1-3-6-16/h1-8,13,15,17-18H,9-12,14,25H2,(H,26,29)(H,27,28)/t17-,18- MNASVSQLOIJTDA-IYARVYRRSA-N 126212 US8778951, 22 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126212&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794036 225152573 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256130 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccnc2)n1 InChI=1S/C22H25ClN6/c23-19-14-27-22(28-17-8-6-16(24)7-9-17)11-18(19)20-4-1-5-21(29-20)26-13-15-3-2-10-25-12-15/h1-5,10-12,14,16-17H,6-9,13,24H2,(H,26,29)(H,27,28)/t16-,17- UCGNEHADSDZOQC-QAQDUYKDSA-N 126213 US8778951, 23 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126213&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405479 225152574 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256131 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(F)c(F)c2)n1 InChI=1S/C23H24ClF2N5/c24-18-13-29-23(30-16-7-5-15(27)6-8-16)11-17(18)21-2-1-3-22(31-21)28-12-14-4-9-19(25)20(26)10-14/h1-4,9-11,13,15-16H,5-8,12,27H2,(H,28,31)(H,29,30)/t15-,16- JRHKNPRVWSBKKT-WKILWMFISA-N 126214 US8778951, 24 Cyclin-T1 Homo sapiens 0.012416 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126214&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405335 225152575 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256132 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccncc2)n1 InChI=1S/C22H25ClN6/c23-19-14-27-22(28-17-6-4-16(24)5-7-17)12-18(19)20-2-1-3-21(29-20)26-13-15-8-10-25-11-9-15/h1-3,8-12,14,16-17H,4-7,13,24H2,(H,26,29)(H,27,28)/t16-,17- BTLKYRQBSPKBGI-QAQDUYKDSA-N 126215 US8778951, 25 Cyclin-T1 Homo sapiens 0.008079 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126215&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794038 225152576 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256133 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C23H24ClF2N5/c24-20-13-29-23(30-18-6-4-17(27)5-7-18)11-19(20)21-2-1-3-22(31-21)28-12-14-8-15(25)10-16(26)9-14/h1-3,8-11,13,17-18H,4-7,12,27H2,(H,28,31)(H,29,30)/t17-,18- DXCNZWURIZVZKK-IYARVYRRSA-N 126216 US8778951, 26 Cyclin-T1 Homo sapiens 0.016256 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126216&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908321 225152577 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256134 N[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1cncc(NCc2cccc(F)c2)n1 InChI=1S/C22H25FN6/c23-17-3-1-2-15(10-17)12-27-22-14-25-13-20(29-22)16-8-9-26-21(11-16)28-19-6-4-18(24)5-7-19/h1-3,8-11,13-14,18-19H,4-7,12,24H2,(H,26,28)(H,27,29)/t18-,19- FTBQWHXNDVMWMG-WGSAOQKQSA-N 126217 US8778951, 27 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126217&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936915 225152578 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256135 N[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H26FN5/c24-18-4-1-3-16(13-18)15-27-22-6-2-5-21(29-22)17-11-12-26-23(14-17)28-20-9-7-19(25)8-10-20/h1-6,11-14,19-20H,7-10,15,25H2,(H,26,28)(H,27,29)/t19-,20- FNFKHXDBFOHAGE-MXVIHJGJSA-N 126219 US8778951, 29 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126219&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793962 225152579 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256136 N[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1cccc(NCc2ccncc2)n1 InChI=1S/C22H26N6/c23-18-4-6-19(7-5-18)27-22-14-17(10-13-25-22)20-2-1-3-21(28-20)26-15-16-8-11-24-12-9-16/h1-3,8-14,18-19H,4-7,15,23H2,(H,25,27)(H,26,28)/t18-,19- WKBAKULLHSZMMK-WGSAOQKQSA-N 126220 US8778951, 30 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126220&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405597 225152580 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256137 N[C@H]1CC[C@@H](CC1)Nc1ncc(Cl)c(n1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C22H24ClFN6/c23-18-13-27-22(28-17-9-7-16(25)8-10-17)30-21(18)19-5-2-6-20(29-19)26-12-14-3-1-4-15(24)11-14/h1-6,11,13,16-17H,7-10,12,25H2,(H,26,29)(H,27,28,30)/t16-,17- XPTJKPHMJXGTMG-QAQDUYKDSA-N 126221 US8778951, 31 Cyclin-T1 Homo sapiens 0.044838 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126221&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794039 225152581 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256138 N[C@H]1CC[C@@H](CC1)Nc1ncc(Cl)c(n1)-c1cccc(NCc2ccncc2)n1 InChI=1S/C21H24ClN7/c22-17-13-26-21(27-16-6-4-15(23)5-7-16)29-20(17)18-2-1-3-19(28-18)25-12-14-8-10-24-11-9-14/h1-3,8-11,13,15-16H,4-7,12,23H2,(H,25,28)(H,26,27,29)/t15-,16- HLXPIJVVSYSLEA-WKILWMFISA-N 126222 US8778951, 32 Cyclin-T1 Homo sapiens 0.015002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126222&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793940 225152582 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256139 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(OC(F)F)c2)n1 InChI=1S/C24H26ClF2N5O/c25-20-14-30-23(31-17-9-7-16(28)8-10-17)12-19(20)21-5-2-6-22(32-21)29-13-15-3-1-4-18(11-15)33-24(26)27/h1-6,11-12,14,16-17,24H,7-10,13,28H2,(H,29,32)(H,30,31)/t16-,17- FXGOJHSHFJLFIA-QAQDUYKDSA-N 126223 US8778951, 33 Cyclin-T1 Homo sapiens 0.026973 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126223&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793961 225152583 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256140 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(Cl)c2)n1 InChI=1S/C23H25Cl2N5/c24-16-4-1-3-15(11-16)13-27-22-6-2-5-21(30-22)19-12-23(28-14-20(19)25)29-18-9-7-17(26)8-10-18/h1-6,11-12,14,17-18H,7-10,13,26H2,(H,27,30)(H,28,29)/t17-,18- MUKAMSPXOXMLKR-IYARVYRRSA-N 126224 US8778951, 34 Cyclin-T1 Homo sapiens 0.048274 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126224&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794053 225152584 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256141 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cncc(F)c2)n1 InChI=1S/C22H24ClFN6/c23-19-13-28-22(29-17-6-4-16(25)5-7-17)9-18(19)20-2-1-3-21(30-20)27-11-14-8-15(24)12-26-10-14/h1-3,8-10,12-13,16-17H,4-7,11,25H2,(H,27,30)(H,28,29)/t16-,17- GFNQXNXLUNXRQL-QAQDUYKDSA-N 126225 US8778951, 35 Cyclin-T1 Homo sapiens 0.055761 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126225&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908322 225152585 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256142 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)ccc2F)n1 InChI=1S/C23H24ClF2N5/c24-19-13-29-23(30-17-7-5-16(27)6-8-17)11-18(19)21-2-1-3-22(31-21)28-12-14-10-15(25)4-9-20(14)26/h1-4,9-11,13,16-17H,5-8,12,27H2,(H,28,31)(H,29,30)/t16-,17- HLMQLCSGRPJMID-QAQDUYKDSA-N 126226 US8778951, 36 Cyclin-T1 Homo sapiens 0.008906 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126226&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405337 225152586 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256143 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C22H30ClN5O/c23-19-14-26-22(27-17-6-4-16(24)5-7-17)12-18(19)20-2-1-3-21(28-20)25-13-15-8-10-29-11-9-15/h1-3,12,14-17H,4-11,13,24H2,(H,25,28)(H,26,27)/t16-,17- XKJMEYZUIQYALK-QAQDUYKDSA-N 126227 US8778951, 37 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126227&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937043 225152587 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256144 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccccc2F)n1 InChI=1S/C23H25ClFN5/c24-19-14-28-23(29-17-10-8-16(26)9-11-17)12-18(19)21-6-3-7-22(30-21)27-13-15-4-1-2-5-20(15)25/h1-7,12,14,16-17H,8-11,13,26H2,(H,27,30)(H,28,29)/t16-,17- VXFLMBZUSHSTGG-QAQDUYKDSA-N 126228 US8778951, 38 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126228&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405527 225152588 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256145 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccccc2Cl)n1 InChI=1S/C23H25Cl2N5/c24-19-5-2-1-4-15(19)13-27-22-7-3-6-21(30-22)18-12-23(28-14-20(18)25)29-17-10-8-16(26)9-11-17/h1-7,12,14,16-17H,8-11,13,26H2,(H,27,30)(H,28,29)/t16-,17- RGJLOPFYIKINRY-QAQDUYKDSA-N 126229 US8778951, 39 Cyclin-T1 Homo sapiens 0.008896 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126229&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405064 225152589 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256146 Cc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1 InChI=1S/C24H28ClN5/c1-16-4-2-5-17(12-16)14-27-23-7-3-6-22(30-23)20-13-24(28-15-21(20)25)29-19-10-8-18(26)9-11-19/h2-7,12-13,15,18-19H,8-11,14,26H2,1H3,(H,27,30)(H,28,29)/t18-,19- GKFIGZDTKUOLII-WGSAOQKQSA-N 126230 US8778951, 40 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126230&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405072 225152590 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256147 COc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1 InChI=1S/C24H28ClN5O/c1-31-19-5-2-4-16(12-19)14-27-23-7-3-6-22(30-23)20-13-24(28-15-21(20)25)29-18-10-8-17(26)9-11-18/h2-7,12-13,15,17-18H,8-11,14,26H2,1H3,(H,27,30)(H,28,29)/t17-,18- PGDBGIZMLDXYSN-IYARVYRRSA-N 126231 US8778951, 41 Cyclin-T1 Homo sapiens 0.01288 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126231&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405073 225152591 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256148 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(OC(F)(F)F)c2)n1 InChI=1S/C24H25ClF3N5O/c25-20-14-31-23(32-17-9-7-16(29)8-10-17)12-19(20)21-5-2-6-22(33-21)30-13-15-3-1-4-18(11-15)34-24(26,27)28/h1-6,11-12,14,16-17H,7-10,13,29H2,(H,30,33)(H,31,32)/t16-,17- WHLVMYSIHPBYEN-QAQDUYKDSA-N 126232 US8778951, 42 Cyclin-T1 Homo sapiens 0.048069 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126232&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405068 225152592 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256149 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cncc(Br)c2)n1 InChI=1S/C22H24BrClN6/c23-15-8-14(10-26-12-15)11-27-21-3-1-2-20(30-21)18-9-22(28-13-19(18)24)29-17-6-4-16(25)5-7-17/h1-3,8-10,12-13,16-17H,4-7,11,25H2,(H,27,30)(H,28,29)/t16-,17- HNTBSNIXVZJICQ-QAQDUYKDSA-N 126233 US8778951, 43 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126233&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405069 225152593 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256150 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(c2)C(F)(F)F)n1 InChI=1S/C24H25ClF3N5/c25-20-14-31-23(32-18-9-7-17(29)8-10-18)12-19(20)21-5-2-6-22(33-21)30-13-15-3-1-4-16(11-15)24(26,27)28/h1-6,11-12,14,17-18H,7-10,13,29H2,(H,30,33)(H,31,32)/t17-,18- ZZBGRPFKGKKFMI-IYARVYRRSA-N 126234 US8778951, 44 Cyclin-T1 Homo sapiens 0.011238 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126234&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405070 225152594 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256151 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(O)c2)n1 InChI=1S/C23H26ClN5O/c24-20-14-27-23(28-17-9-7-16(25)8-10-17)12-19(20)21-5-2-6-22(29-21)26-13-15-3-1-4-18(30)11-15/h1-6,11-12,14,16-17,30H,7-10,13,25H2,(H,26,29)(H,27,28)/t16-,17- FQZQPCZXXFXWSF-QAQDUYKDSA-N 126236 US8778951, 46 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126236&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405078 225152595 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256152 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(F)cc2)n1 InChI=1S/C23H25ClFN5/c24-20-14-28-23(29-18-10-8-17(26)9-11-18)12-19(20)21-2-1-3-22(30-21)27-13-15-4-6-16(25)7-5-15/h1-7,12,14,17-18H,8-11,13,26H2,(H,27,30)(H,28,29)/t17-,18- WQAQBCPBTHBPIO-IYARVYRRSA-N 126237 US8778951, 47 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126237&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793945 225152596 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256153 Cc1ccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)cc1 InChI=1S/C24H28ClN5/c1-16-5-7-17(8-6-16)14-27-23-4-2-3-22(30-23)20-13-24(28-15-21(20)25)29-19-11-9-18(26)10-12-19/h2-8,13,15,18-19H,9-12,14,26H2,1H3,(H,27,30)(H,28,29)/t18-,19- XQOWKYSWSFFZHH-WGSAOQKQSA-N 126238 US8778951, 48 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126238&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793943 225152597 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256154 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(cc2)C(F)(F)F)n1 InChI=1S/C24H25ClF3N5/c25-20-14-31-23(32-18-10-8-17(29)9-11-18)12-19(20)21-2-1-3-22(33-21)30-13-15-4-6-16(7-5-15)24(26,27)28/h1-7,12,14,17-18H,8-11,13,29H2,(H,30,33)(H,31,32)/t17-,18- IILRBDQYISJYKD-IYARVYRRSA-N 126239 US8778951, 49 Cyclin-T1 Homo sapiens 0.01443 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126239&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794054 225152598 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256155 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(OC(F)F)cc2)n1 InChI=1S/C24H26ClF2N5O/c25-20-14-30-23(31-17-8-6-16(28)7-9-17)12-19(20)21-2-1-3-22(32-21)29-13-15-4-10-18(11-5-15)33-24(26)27/h1-5,10-12,14,16-17,24H,6-9,13,28H2,(H,29,32)(H,30,31)/t16-,17- VCACQQXGMUBMDT-QAQDUYKDSA-N 126240 US8778951, 50 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126240&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405530 225152599 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256156 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(OC(F)(F)F)cc2)n1 InChI=1S/C24H25ClF3N5O/c25-20-14-31-23(32-17-8-6-16(29)7-9-17)12-19(20)21-2-1-3-22(33-21)30-13-15-4-10-18(11-5-15)34-24(26,27)28/h1-5,10-12,14,16-17H,6-9,13,29H2,(H,30,33)(H,31,32)/t16-,17- FNLFUTBMMZDDIP-QAQDUYKDSA-N 126241 US8778951, 51 Cyclin-T1 Homo sapiens 0.017367 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126241&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405528 225152600 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256157 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(Cl)cc2)n1 InChI=1S/C23H25Cl2N5/c24-16-6-4-15(5-7-16)13-27-22-3-1-2-21(30-22)19-12-23(28-14-20(19)25)29-18-10-8-17(26)9-11-18/h1-7,12,14,17-18H,8-11,13,26H2,(H,27,30)(H,28,29)/t17-,18- CLSJAWWFKBVCQV-IYARVYRRSA-N 126242 US8778951, 52 Cyclin-T1 Homo sapiens 0.019224 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126242&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405481 225152601 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256158 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCCCC2)n1 InChI=1S/C24H34ClN5/c25-21-16-28-24(29-19-11-9-17(14-26)10-12-19)13-20(21)22-7-4-8-23(30-22)27-15-18-5-2-1-3-6-18/h4,7-8,13,16-19H,1-3,5-6,9-12,14-15,26H2,(H,27,30)(H,28,29)/t17-,19- JFSVBJSPUAJNKP-UAPYVXQJSA-N 126243 US8778951, 53 Cyclin-T1 Homo sapiens 0.011128 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126243&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793987 225152602 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256159 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccccc2)n1 InChI=1S/C24H28ClN5/c25-21-16-28-24(29-19-11-9-17(14-26)10-12-19)13-20(21)22-7-4-8-23(30-22)27-15-18-5-2-1-3-6-18/h1-8,13,16-17,19H,9-12,14-15,26H2,(H,27,30)(H,28,29)/t17-,19- JDSQHSZBUZZGJW-UAPYVXQJSA-N 126244 US8778951, 54 Cyclin-T1 Homo sapiens 0.023156 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126244&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793944 225152603 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256160 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccnc2)n1 InChI=1S/C23H27ClN6/c24-20-15-28-23(29-18-8-6-16(12-25)7-9-18)11-19(20)21-4-1-5-22(30-21)27-14-17-3-2-10-26-13-17/h1-5,10-11,13,15-16,18H,6-9,12,14,25H2,(H,27,30)(H,28,29)/t16-,18- ONZOUDQIBCDEGX-SAABIXHNSA-N 126245 US8778951, 55 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126245&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405340 225152604 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256161 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cncc(F)c2)n1 InChI=1S/C23H26ClFN6/c24-20-14-29-23(30-18-6-4-15(10-26)5-7-18)9-19(20)21-2-1-3-22(31-21)28-12-16-8-17(25)13-27-11-16/h1-3,8-9,11,13-15,18H,4-7,10,12,26H2,(H,28,31)(H,29,30)/t15-,18- CKUNKEPDNQANSG-RZDIXWSQSA-N 126246 US8778951, 56 Cyclin-T1 Homo sapiens 0.039262 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126246&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405127 225152605 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256162 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccncc2)n1 InChI=1S/C23H27ClN6/c24-20-15-28-23(29-18-6-4-16(13-25)5-7-18)12-19(20)21-2-1-3-22(30-21)27-14-17-8-10-26-11-9-17/h1-3,8-12,15-16,18H,4-7,13-14,25H2,(H,27,30)(H,28,29)/t16-,18- WLPKUYWGEAKKMH-SAABIXHNSA-N 126247 US8778951, 57 Cyclin-T1 Homo sapiens 0.03259 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126247&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405531 225152606 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256163 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)ccc2F)n1 InChI=1S/C24H26ClF2N5/c25-20-14-30-24(31-18-7-4-15(12-28)5-8-18)11-19(20)22-2-1-3-23(32-22)29-13-16-10-17(26)6-9-21(16)27/h1-3,6,9-11,14-15,18H,4-5,7-8,12-13,28H2,(H,29,32)(H,30,31)/t15-,18- UWYOEDRXPUYKSP-RZDIXWSQSA-N 126248 US8778951, 58 Cyclin-T1 Homo sapiens 0.031203 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126248&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405128 225152607 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256164 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(Cl)c2)n1 InChI=1S/C24H27Cl2N5/c25-18-4-1-3-17(11-18)14-28-23-6-2-5-22(31-23)20-12-24(29-15-21(20)26)30-19-9-7-16(13-27)8-10-19/h1-6,11-12,15-16,19H,7-10,13-14,27H2,(H,28,31)(H,29,30)/t16-,19- XPMMKVDMDZZNFT-RUCARUNLSA-N 126249 US8778951, 59 Cyclin-T1 Homo sapiens 0.009128 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126249&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405126 225152608 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256165 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(F)c(F)c2)n1 InChI=1S/C24H26ClF2N5/c25-19-14-30-24(31-17-7-4-15(12-28)5-8-17)11-18(19)22-2-1-3-23(32-22)29-13-16-6-9-20(26)21(27)10-16/h1-3,6,9-11,14-15,17H,4-5,7-8,12-13,28H2,(H,29,32)(H,30,31)/t15-,17- YRTSZFCRBUIGNL-JCNLHEQBSA-N 126250 US8778951, 60 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126250&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794040 225152609 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256166 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(OC(F)F)c2)n1 InChI=1S/C25H28ClF2N5O/c26-21-15-31-24(32-18-9-7-16(13-29)8-10-18)12-20(21)22-5-2-6-23(33-22)30-14-17-3-1-4-19(11-17)34-25(27)28/h1-6,11-12,15-16,18,25H,7-10,13-14,29H2,(H,30,33)(H,31,32)/t16-,18- DIAHBBNYFHMWSZ-SAABIXHNSA-N 126251 US8778951, 61 Cyclin-T1 Homo sapiens 0.0181 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126251&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405504 225152610 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256167 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C24H26ClF2N5/c25-21-14-30-24(31-19-6-4-15(12-28)5-7-19)11-20(21)22-2-1-3-23(32-22)29-13-16-8-17(26)10-18(27)9-16/h1-3,8-11,14-15,19H,4-7,12-13,28H2,(H,29,32)(H,30,31)/t15-,19- IHVNFRFRSHNMLX-RHDGDCLCSA-N 126252 US8778951, 62 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126252&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793988 225152611 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256168 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(F)cc2)n1 InChI=1S/C24H27ClFN5/c25-21-15-29-24(30-19-10-6-16(13-27)7-11-19)12-20(21)22-2-1-3-23(31-22)28-14-17-4-8-18(26)9-5-17/h1-5,8-9,12,15-16,19H,6-7,10-11,13-14,27H2,(H,28,31)(H,29,30)/t16-,19- RUMZXYJFNQMYCB-RUCARUNLSA-N 126253 US8778951, 63 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126253&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793989 225152612 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256169 CC(C)(C)OC(=O)N1CCC(CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C27H31ClFN5O2/c1-27(2,3)36-26(35)34-12-10-20(11-13-34)32-25-15-21(22(28)17-31-25)23-8-5-9-24(33-23)30-16-18-6-4-7-19(29)14-18/h4-9,14-15,17,20H,10-13,16H2,1-3H3,(H,30,33)(H,31,32) CPOOLWPLIIVVQF-UHFFFAOYSA-N 126254 US8778951, 64 Cyclin-T1 Homo sapiens 0.054559 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126254&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936988 225152613 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256170 Clc1cnc(NC2CCNCC2)cc1-c1cccc(NCC2CCCCC2)n1 InChI=1S/C22H30ClN5/c23-19-15-26-22(27-17-9-11-24-12-10-17)13-18(19)20-7-4-8-21(28-20)25-14-16-5-2-1-3-6-16/h4,7-8,13,15-17,24H,1-3,5-6,9-12,14H2,(H,25,28)(H,26,27) QUJGRVFTDWKGGG-UHFFFAOYSA-N 126255 US8778951, 65 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126255&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793990 225152614 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256171 Clc1cnc(NC2CCNCC2)cc1-c1cccc(NCc2ccccc2)n1 InChI=1S/C22H24ClN5/c23-19-15-26-22(27-17-9-11-24-12-10-17)13-18(19)20-7-4-8-21(28-20)25-14-16-5-2-1-3-6-16/h1-8,13,15,17,24H,9-12,14H2,(H,25,28)(H,26,27) OPCXUUVORVDZSL-UHFFFAOYSA-N 126256 US8778951, 66 Cyclin-T1 Homo sapiens 0.017131 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126256&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794055 225152615 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256173 Fc1cc(F)cc(CNc2cccc(n2)-c2cc(NC3CCNCC3)ncc2Cl)c1 InChI=1S/C22H22ClF2N5/c23-19-13-28-22(29-17-4-6-26-7-5-17)11-18(19)20-2-1-3-21(30-20)27-12-14-8-15(24)10-16(25)9-14/h1-3,8-11,13,17,26H,4-7,12H2,(H,27,30)(H,28,29) NSNOXXOTNCQBOU-UHFFFAOYSA-N 126258 US8778951, 68 Cyclin-T1 Homo sapiens 0.274123 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126258&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405601 225152617 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256174 Clc1cnc(NC2CCNCC2)cc1-c1cccc(NCc2ccncc2)n1 InChI=1S/C21H23ClN6/c22-18-14-26-21(27-16-6-10-24-11-7-16)12-17(18)19-2-1-3-20(28-19)25-13-15-4-8-23-9-5-15/h1-5,8-9,12,14,16,24H,6-7,10-11,13H2,(H,25,28)(H,26,27) RNOMTFCEQZQMQB-UHFFFAOYSA-N 126259 US8778951, 69 Cyclin-T1 Homo sapiens 0.1544 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126259&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794041 225152618 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256175 Clc1cccc(CNc2cccc(n2)-c2cc(NC3CCNCC3)ncc2Cl)c1 InChI=1S/C22H23Cl2N5/c23-16-4-1-3-15(11-16)13-26-21-6-2-5-20(29-21)18-12-22(27-14-19(18)24)28-17-7-9-25-10-8-17/h1-6,11-12,14,17,25H,7-10,13H2,(H,26,29)(H,27,28) RWOOWXJOOKCETB-UHFFFAOYSA-N 126260 US8778951, 70 Cyclin-T1 Homo sapiens 0.173426 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126260&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405606 225152619 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256176 Fc1ccc(CNc2cccc(n2)-c2cc(NC3CCNCC3)ncc2Cl)cc1F InChI=1S/C22H22ClF2N5/c23-17-13-28-22(29-15-6-8-26-9-7-15)11-16(17)20-2-1-3-21(30-20)27-12-14-4-5-18(24)19(25)10-14/h1-5,10-11,13,15,26H,6-9,12H2,(H,27,30)(H,28,29) HUPGOLDXANYTAH-UHFFFAOYSA-N 126261 US8778951, 71 Cyclin-T1 Homo sapiens 0.027388 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126261&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794014 225152620 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256177 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCCCCC2)n1 InChI=1S/C24H34ClN5/c25-21-16-28-24(29-19-12-10-18(26)11-13-19)14-20(21)22-8-5-9-23(30-22)27-15-17-6-3-1-2-4-7-17/h5,8-9,14,16-19H,1-4,6-7,10-13,15,26H2,(H,27,30)(H,28,29)/t18-,19- LWVMUKBMEMDAMY-WGSAOQKQSA-N 126262 US8778951, 72 Cyclin-T1 Homo sapiens 0.114363 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126262&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793946 225152621 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256178 CN(Cc1ccccc1)c1cccc(n1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C24H28ClN5/c1-30(16-17-6-3-2-4-7-17)24-9-5-8-22(29-24)20-14-23(27-15-21(20)25)28-19-12-10-18(26)11-13-19/h2-9,14-15,18-19H,10-13,16,26H2,1H3,(H,27,28)/t18-,19- DPUSROIQZPAMDT-WGSAOQKQSA-N 126263 US8778951, 73 Cyclin-T1 Homo sapiens 0.035218 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126263&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405339 225152622 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256179 CN(Cc1cccc(F)c1)c1cccc(n1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C24H27ClFN5/c1-31(15-16-4-2-5-17(26)12-16)24-7-3-6-22(30-24)20-13-23(28-14-21(20)25)29-19-10-8-18(27)9-11-19/h2-7,12-14,18-19H,8-11,15,27H2,1H3,(H,28,29)/t18-,19- NBYOWOXMKLFPKB-WGSAOQKQSA-N 126264 US8778951, 74 Cyclin-T1 Homo sapiens 0.041585 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126264&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405604 225152623 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256180 CCS(=O)(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5O2S/c1-2-35(33,34)32-20-11-9-19(10-12-20)30-25-14-21(22(26)16-29-25)23-7-4-8-24(31-23)28-15-17-5-3-6-18(27)13-17/h3-8,13-14,16,19-20,32H,2,9-12,15H2,1H3,(H,28,31)(H,29,30)/t19-,20- HFGOPUXLCKAMFX-MXVIHJGJSA-N 126265 US8778951, 75 Cyclin-T1 Homo sapiens 0.01353 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126265&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405600 225152624 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256181 CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C26H31ClFN5O2S/c1-2-36(34,35)31-16-18-9-11-21(12-10-18)32-26-14-22(23(27)17-30-26)24-7-4-8-25(33-24)29-15-19-5-3-6-20(28)13-19/h3-8,13-14,17-18,21,31H,2,9-12,15-16H2,1H3,(H,29,33)(H,30,32)/t18-,21- APNZKVCAIGMCNL-XGAFWQRZSA-N 126266 US8778951, 76 Cyclin-T1 Homo sapiens 0.011082 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126266&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793963 225152625 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256182 CN1CCC[C@H]1C(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C29H34ClFN6O/c1-37-14-4-8-26(37)29(38)35-22-12-10-21(11-13-22)34-28-16-23(24(30)18-33-28)25-7-3-9-27(36-25)32-17-19-5-2-6-20(31)15-19/h2-3,5-7,9,15-16,18,21-22,26H,4,8,10-14,17H2,1H3,(H,32,36)(H,33,34)(H,35,38)/t21-,22-,26-/m0/s1 ULTJDROPFLHIPC-MCEYFSPLSA-N 126267 US8778951, 77 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126267&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405496 225152626 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256183 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@@H](CC3)NC(=O)c3cccnc3)ncc2Cl)c1 InChI=1S/C29H28ClFN6O/c30-25-18-34-28(35-22-9-11-23(12-10-22)36-29(38)20-5-3-13-32-17-20)15-24(25)26-7-2-8-27(37-26)33-16-19-4-1-6-21(31)14-19/h1-8,13-15,17-18,22-23H,9-12,16H2,(H,33,37)(H,34,35)(H,36,38)/t22-,23- HYIYGOQGKSWAIW-YHBQERECSA-N 126268 US8778951, 78 Cyclin-T1 Homo sapiens 0.024249 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126268&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405541 225152627 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256184 CN(C)CC(=O)NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C28H34ClFN6O/c1-36(2)18-28(37)33-15-19-9-11-22(12-10-19)34-27-14-23(24(29)17-32-27)25-7-4-8-26(35-25)31-16-20-5-3-6-21(30)13-20/h3-8,13-14,17,19,22H,9-12,15-16,18H2,1-2H3,(H,31,35)(H,32,34)(H,33,37)/t19-,22- KSRRMRJZYQKIEM-XYWHTSSQSA-N 126269 US8778951, 79 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126269&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405146 225152628 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256185 CN1CCC[C@H]1C(=O)NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C30H36ClFN6O/c1-38-14-4-8-27(38)30(39)35-17-20-10-12-23(13-11-20)36-29-16-24(25(31)19-34-29)26-7-3-9-28(37-26)33-18-21-5-2-6-22(32)15-21/h2-3,5-7,9,15-16,19-20,23,27H,4,8,10-14,17-18H2,1H3,(H,33,37)(H,34,36)(H,35,39)/t20-,23-,27-/m0/s1 NCQPYDLKEWWEKN-XAXKJMDRSA-N 126270 US8778951, 80 Cyclin-T1 Homo sapiens 0.031705 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126270&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405140 225152629 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256186 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](CNC(=O)c4cccnc4)CC3)ncc2Cl)c1 InChI=1S/C30H30ClFN6O/c31-26-19-35-29(37-24-11-9-20(10-12-24)16-36-30(39)22-5-3-13-33-18-22)15-25(26)27-7-2-8-28(38-27)34-17-21-4-1-6-23(32)14-21/h1-8,13-15,18-20,24H,9-12,16-17H2,(H,34,38)(H,35,37)(H,36,39)/t20-,24- GJLXEMPUSDDIKS-LSNLESRRSA-N 126271 US8778951, 81 Cyclin-T1 Homo sapiens 0.054218 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126271&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405338 225152630 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256187 CN(C)CC(=O)N1CCC(CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C26H30ClFN6O/c1-33(2)17-26(35)34-11-9-20(10-12-34)31-25-14-21(22(27)16-30-25)23-7-4-8-24(32-23)29-15-18-5-3-6-19(28)13-18/h3-8,13-14,16,20H,9-12,15,17H2,1-2H3,(H,29,32)(H,30,31) NDVSUBMXHGTGLN-UHFFFAOYSA-N 126272 US8778951, 82 Cyclin-T1 Homo sapiens 0.009047 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126272&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793947 225152631 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256188 CN1CCC[C@H]1C(=O)N1CCC(CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C28H32ClFN6O/c1-35-12-4-8-25(35)28(37)36-13-10-21(11-14-36)33-27-16-22(23(29)18-32-27)24-7-3-9-26(34-24)31-17-19-5-2-6-20(30)15-19/h2-3,5-7,9,15-16,18,21,25H,4,8,10-14,17H2,1H3,(H,31,34)(H,32,33)/t25-/m0/s1 GYLDXHXMWUNLIQ-VWLOTQADSA-N 126273 US8778951, 83 Cyclin-T1 Homo sapiens 0.011615 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126273&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794043 225152632 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256189 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCN(CC3)C(=O)c3cccnc3)ncc2Cl)c1 InChI=1S/C28H26ClFN6O/c29-24-18-33-27(34-22-9-12-36(13-10-22)28(37)20-5-3-11-31-17-20)15-23(24)25-7-2-8-26(35-25)32-16-19-4-1-6-21(30)14-19/h1-8,11,14-15,17-18,22H,9-10,12-13,16H2,(H,32,35)(H,33,34) FFUCVDJPRZNSPX-UHFFFAOYSA-N 126274 US8778951, 84 Cyclin-T1 Homo sapiens 0.014118 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126274&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793948 225152633 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256190 CCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5/c1-2-28-19-9-11-20(12-10-19)31-25-14-21(22(26)16-30-25)23-7-4-8-24(32-23)29-15-17-5-3-6-18(27)13-17/h3-8,13-14,16,19-20,28H,2,9-12,15H2,1H3,(H,29,32)(H,30,31)/t19-,20- WQOBKUHLKNDRCJ-MXVIHJGJSA-N 126275 US8778951, 85 Cyclin-T1 Homo sapiens 0.068526 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126275&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793966 225152634 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256191 Clc1cnc(N[C@@H]2CCCNC2)cc1-c1cccc(NCC2CCCCC2)n1 InChI=1S/C22H30ClN5/c23-19-15-26-22(27-17-8-5-11-24-14-17)12-18(19)20-9-4-10-21(28-20)25-13-16-6-2-1-3-7-16/h4,9-10,12,15-17,24H,1-3,5-8,11,13-14H2,(H,25,28)(H,26,27)/t17-/m1/s1 QKMJCFGAACZSJG-QGZVFWFLSA-N 126276 US8778951, 86 Cyclin-T1 Homo sapiens 0.08146 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126276&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405100 225152635 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256192 Clc1cnc(N[C@@H]2CCCNC2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C21H28ClN5O/c22-18-14-25-21(26-16-3-2-8-23-13-16)11-17(18)19-4-1-5-20(27-19)24-12-15-6-9-28-10-7-15/h1,4-5,11,14-16,23H,2-3,6-10,12-13H2,(H,24,27)(H,25,26)/t16-/m1/s1 WHTSKQHRSNNTPF-MRXNPFEDSA-N 126277 US8778951, 87 Cyclin-T1 Homo sapiens 0.068978 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126277&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794044 225152636 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256193 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@@H]3CCCNC3)ncc2Cl)c1 InChI=1S/C22H23ClFN5/c23-19-14-27-22(28-17-6-3-9-25-13-17)11-18(19)20-7-2-8-21(29-20)26-12-15-4-1-5-16(24)10-15/h1-2,4-5,7-8,10-11,14,17,25H,3,6,9,12-13H2,(H,26,29)(H,27,28)/t17-/m1/s1 DRSVGIDJQGJGIF-QGZVFWFLSA-N 126278 US8778951, 88 Cyclin-T1 Homo sapiens 0.011003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126278&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405141 225152637 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256194 Fc1cc(F)cc(CNc2cccc(n2)-c2cc(N[C@@H]3CCCNC3)ncc2Cl)c1 InChI=1S/C22H22ClF2N5/c23-19-13-28-22(29-17-3-2-6-26-12-17)10-18(19)20-4-1-5-21(30-20)27-11-14-7-15(24)9-16(25)8-14/h1,4-5,7-10,13,17,26H,2-3,6,11-12H2,(H,27,30)(H,28,29)/t17-/m1/s1 GVIAXNCAIPTPFV-QGZVFWFLSA-N 126279 US8778951, 89 Cyclin-T1 Homo sapiens 2.582156 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126279&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793970 225152638 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256195 Clc1cnc(N[C@@H]2CCCNC2)cc1-c1cccc(NCc2ccncc2)n1 InChI=1S/C21H23ClN6/c22-18-14-26-21(27-16-3-2-8-24-13-16)11-17(18)19-4-1-5-20(28-19)25-12-15-6-9-23-10-7-15/h1,4-7,9-11,14,16,24H,2-3,8,12-13H2,(H,25,28)(H,26,27)/t16-/m1/s1 OQZWJLGCIKHVRP-MRXNPFEDSA-N 126280 US8778951, 90 Cyclin-T1 Homo sapiens 2.960356 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126280&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405614 225152639 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256196 Fc1ccc(CNc2cccc(n2)-c2cc(N[C@@H]3CCCNC3)ncc2Cl)cc1F InChI=1S/C22H22ClF2N5/c23-17-13-28-22(29-15-3-2-8-26-12-15)10-16(17)20-4-1-5-21(30-20)27-11-14-6-7-18(24)19(25)9-14/h1,4-7,9-10,13,15,26H,2-3,8,11-12H2,(H,27,30)(H,28,29)/t15-/m1/s1 DSNZYMMKLFJCSP-OAHLLOKOSA-N 126281 US8778951, 91 Cyclin-T1 Homo sapiens 0.335581 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126281&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405532 225152640 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256197 Clc1cnc(N[C@H]2CCCNC2)cc1-c1cccc(NCC2CCCCC2)n1 InChI=1S/C22H30ClN5/c23-19-15-26-22(27-17-8-5-11-24-14-17)12-18(19)20-9-4-10-21(28-20)25-13-16-6-2-1-3-7-16/h4,9-10,12,15-17,24H,1-3,5-8,11,13-14H2,(H,25,28)(H,26,27)/t17-/m0/s1 QKMJCFGAACZSJG-KRWDZBQOSA-N 126282 US8778951, 92 Cyclin-T1 Homo sapiens 0.295616 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126282&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794015 225152641 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256198 Clc1cnc(N[C@H]2CCCNC2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C21H28ClN5O/c22-18-14-25-21(26-16-3-2-8-23-13-16)11-17(18)19-4-1-5-20(27-19)24-12-15-6-9-28-10-7-15/h1,4-5,11,14-16,23H,2-3,6-10,12-13H2,(H,24,27)(H,25,26)/t16-/m0/s1 WHTSKQHRSNNTPF-INIZCTEOSA-N 126283 US8778951, 93 Cyclin-T1 Homo sapiens 0.928257 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126283&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793951 225152642 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256199 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CCCNC3)ncc2Cl)c1 InChI=1S/C22H23ClFN5/c23-19-14-27-22(28-17-6-3-9-25-13-17)11-18(19)20-7-2-8-21(29-20)26-12-15-4-1-5-16(24)10-15/h1-2,4-5,7-8,10-11,14,17,25H,3,6,9,12-13H2,(H,26,29)(H,27,28)/t17-/m0/s1 DRSVGIDJQGJGIF-KRWDZBQOSA-N 126284 US8778951, 94 Cyclin-T1 Homo sapiens 0.50746 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126284&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405147 225152643 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256200 Fc1cc(F)cc(CNc2cccc(n2)-c2cc(N[C@H]3CCCNC3)ncc2Cl)c1 InChI=1S/C22H22ClF2N5/c23-19-13-28-22(29-17-3-2-6-26-12-17)10-18(19)20-4-1-5-21(30-20)27-11-14-7-15(24)9-16(25)8-14/h1,4-5,7-10,13,17,26H,2-3,6,11-12H2,(H,27,30)(H,28,29)/t17-/m0/s1 GVIAXNCAIPTPFV-KRWDZBQOSA-N 126285 US8778951, 95 Cyclin-T1 Homo sapiens 1.95142 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126285&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793950 225152644 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256201 Clc1cnc(N[C@H]2CCCNC2)cc1-c1cccc(NCc2ccncc2)n1 InChI=1S/C21H23ClN6/c22-18-14-26-21(27-16-3-2-8-24-13-16)11-17(18)19-4-1-5-20(28-19)25-12-15-6-9-23-10-7-15/h1,4-7,9-11,14,16,24H,2-3,8,12-13H2,(H,25,28)(H,26,27)/t16-/m0/s1 OQZWJLGCIKHVRP-INIZCTEOSA-N 126286 US8778951, 96 Cyclin-T1 Homo sapiens 1.276694065 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126286&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793949 225152645 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256202 Fc1ccc(CNc2cccc(n2)-c2cc(N[C@H]3CCCNC3)ncc2Cl)cc1F InChI=1S/C22H22ClF2N5/c23-17-13-28-22(29-15-3-2-8-26-12-15)10-16(17)20-4-1-5-21(30-20)27-11-14-6-7-18(24)19(25)9-14/h1,4-7,9-10,13,15,26H,2-3,8,11-12H2,(H,27,30)(H,28,29)/t15-/m0/s1 DSNZYMMKLFJCSP-HNNXBMFYSA-N 126287 US8778951, 97 Cyclin-T1 Homo sapiens 0.339265455 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126287&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405602 225152646 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256203 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCc2cccc(F)c2)n1 InChI=1S/C22H24ClFN6/c23-19-11-28-21(29-17-6-4-16(25)5-7-17)9-18(19)20-12-26-13-22(30-20)27-10-14-2-1-3-15(24)8-14/h1-3,8-9,11-13,16-17H,4-7,10,25H2,(H,27,30)(H,28,29)/t16-,17- OWHGUVLQPUQAKI-QAQDUYKDSA-N 126288 US8778951, 98 Cyclin-T1 Homo sapiens 0.415725004 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126288&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907432 225152647 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256204 CC(C)CN1CCC(CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C26H31ClFN5/c1-18(2)17-33-11-9-21(10-12-33)31-26-14-22(23(27)16-30-26)24-7-4-8-25(32-24)29-15-19-5-3-6-20(28)13-19/h3-8,13-14,16,18,21H,9-12,15,17H2,1-2H3,(H,29,32)(H,30,31) MYLDFXUAXLEGDB-UHFFFAOYSA-N 126289 US8778951, 99 Cyclin-T1 Homo sapiens 0.679432727 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126289&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793967 225152648 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256205 CN1CCC(CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H25ClFN5/c1-30-10-8-18(9-11-30)28-23-13-19(20(24)15-27-23)21-6-3-7-22(29-21)26-14-16-4-2-5-17(25)12-16/h2-7,12-13,15,18H,8-11,14H2,1H3,(H,26,29)(H,27,28) YFAWQUWJXZQAPK-UHFFFAOYSA-N 126290 US8778951, 100 Cyclin-T1 Homo sapiens 0.308717658 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126290&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405536 225152649 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256206 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@H]2CCCO2)n1 InChI=1S/C21H28ClN5O/c22-18-13-25-21(26-15-8-6-14(23)7-9-15)11-17(18)19-4-1-5-20(27-19)24-12-16-3-2-10-28-16/h1,4-5,11,13-16H,2-3,6-10,12,23H2,(H,24,27)(H,25,26)/t14-,15-,16-/m1/s1 PHHPXJDRQAFCBI-BZUAXINKSA-N 126291 US8778951, 101 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126291&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405537 225152650 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256207 CCN(Cc1ccncc1)c1cccc(n1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C24H29ClN6/c1-2-31(16-17-10-12-27-13-11-17)24-5-3-4-22(30-24)20-14-23(28-15-21(20)25)29-19-8-6-18(26)7-9-19/h3-5,10-15,18-19H,2,6-9,16,26H2,1H3,(H,28,29)/t18-,19- PWVTVPUDWRERLL-WGSAOQKQSA-N 126292 US8778951, 102 Cyclin-T1 Homo sapiens 0.120571151 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126292&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405539 225152651 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256208 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@@H]2CCCO2)n1 InChI=1S/C21H28ClN5O/c22-18-13-25-21(26-15-8-6-14(23)7-9-15)11-17(18)19-4-1-5-20(27-19)24-12-16-3-2-10-28-16/h1,4-5,11,13-16H,2-3,6-10,12,23H2,(H,24,27)(H,25,26)/t14-,15-,16-/m0/s1 PHHPXJDRQAFCBI-JYJNAYRXSA-N 126293 US8778951, 103 Cyclin-T1 Homo sapiens 0.133698728 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126293&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405540 225152652 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256209 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCCOC2)n1 InChI=1S/C22H30ClN5O/c23-19-13-26-22(27-17-8-6-16(24)7-9-17)11-18(19)20-4-1-5-21(28-20)25-12-15-3-2-10-29-14-15/h1,4-5,11,13,15-17H,2-3,6-10,12,14,24H2,(H,25,28)(H,26,27)/t15?,16-,17- NDOZPWULCVWYRD-ATBAIXNZSA-N 126294 US8778951, 104 Cyclin-T1 Homo sapiens 0.140890633 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126294&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405543 225152653 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256210 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(n1)N1CCC(CC1)c1ccccc1 InChI=1S/C27H32ClN5/c28-24-18-30-26(31-22-11-9-21(29)10-12-22)17-23(24)25-7-4-8-27(32-25)33-15-13-20(14-16-33)19-5-2-1-3-6-19/h1-8,17-18,20-22H,9-16,29H2,(H,30,31)/t21-,22- KIWHLHPFZAHJKL-HZCBDIJESA-N 126295 US8778951, 105 Cyclin-T1 Homo sapiens 0.0180851 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126295&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793952 225152654 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256211 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2COCCO2)n1 InChI=1S/C21H28ClN5O2/c22-18-12-25-21(26-15-6-4-14(23)5-7-15)10-17(18)19-2-1-3-20(27-19)24-11-16-13-28-8-9-29-16/h1-3,10,12,14-16H,4-9,11,13,23H2,(H,24,27)(H,25,26)/t14-,15-,16? ZCSIFJATMPQSDU-MRJYIUEKSA-N 126296 US8778951, 106 Cyclin-T1 Homo sapiens 0.059240258 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126296&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405067 225152655 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256212 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(OCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O/c24-20-13-27-22(28-18-9-7-17(26)8-10-18)12-19(20)21-5-2-6-23(29-21)30-14-15-3-1-4-16(25)11-15/h1-6,11-13,17-18H,7-10,14,26H2,(H,27,28)/t17-,18- XVVJNOZQKOXYQC-IYARVYRRSA-N 126297 US8778951, 107 Cyclin-T1 Homo sapiens 0.015318231 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126297&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405497 225152656 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256213 CN(CC1CCOCC1)c1cccc(n1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C23H32ClN5O/c1-29(15-16-9-11-30-12-10-16)23-4-2-3-21(28-23)19-13-22(26-14-20(19)24)27-18-7-5-17(25)6-8-18/h2-4,13-14,16-18H,5-12,15,25H2,1H3,(H,26,27)/t17-,18- CMWWRZPMJAGHCV-IYARVYRRSA-N 126298 US8778951, 108 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126298&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405352 225152657 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256214 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cnc(N)nc2)n1 InChI=1S/C21H25ClN8/c22-17-12-26-20(29-15-6-4-14(23)5-7-15)8-16(17)18-2-1-3-19(30-18)25-9-13-10-27-21(24)28-11-13/h1-3,8,10-12,14-15H,4-7,9,23H2,(H,25,30)(H,26,29)(H2,24,27,28)/t14-,15- UDNPPLOOKYPNHT-SHTZXODSSA-N 126299 US8778951, 109 Cyclin-T1 Homo sapiens 0.015815541 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126299&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793969 225152658 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256215 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](CN4CCCCC4)CC3)ncc2Cl)c1 InChI=1S/C29H35ClFN5/c30-26-19-33-29(34-24-12-10-21(11-13-24)20-36-14-2-1-3-15-36)17-25(26)27-8-5-9-28(35-27)32-18-22-6-4-7-23(31)16-22/h4-9,16-17,19,21,24H,1-3,10-15,18,20H2,(H,32,35)(H,33,34)/t21-,24- UHIHKVLTJOYINZ-SAIGFBBZSA-N 126300 US8778951, 110 Cyclin-T1 Homo sapiens 0.025176571 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126300&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793968 225152659 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256216 CN1CCN(C[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCc3cccc(F)c3)n2)CC1 InChI=1S/C29H36ClFN6/c1-36-12-14-37(15-13-36)20-21-8-10-24(11-9-21)34-29-17-25(26(30)19-33-29)27-6-3-7-28(35-27)32-18-22-4-2-5-23(31)16-22/h2-7,16-17,19,21,24H,8-15,18,20H2,1H3,(H,32,35)(H,33,34)/t21-,24- HJOPYLAOUXMCKO-SAIGFBBZSA-N 126301 US8778951, 111 Cyclin-T1 Homo sapiens 0.030797253 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126301&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405612 225152660 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256217 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](CN4CCCC4)CC3)ncc2Cl)c1 InChI=1S/C28H33ClFN5/c29-25-18-32-28(33-23-11-9-20(10-12-23)19-35-13-1-2-14-35)16-24(25)26-7-4-8-27(34-26)31-17-21-5-3-6-22(30)15-21/h3-8,15-16,18,20,23H,1-2,9-14,17,19H2,(H,31,34)(H,32,33)/t20-,23- GRNLPIDKQRBYOH-JKIUYZKVSA-N 126302 US8778951, 112 Cyclin-T1 Homo sapiens 0.027282158 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126302&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405607 225152661 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256218 CNC(=O)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H27ClFN5O/c1-28-25(33)17-8-10-19(11-9-17)31-24-13-20(21(26)15-30-24)22-6-3-7-23(32-22)29-14-16-4-2-5-18(27)12-16/h2-7,12-13,15,17,19H,8-11,14H2,1H3,(H,28,33)(H,29,32)(H,30,31)/t17-,19- DXPKNXVKILXJHO-UAPYVXQJSA-N 126303 US8778951, 113 Cyclin-T1 Homo sapiens 0.050224047 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126303&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793954 225152662 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256219 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O/c24-20-14-27-23(28-17-7-9-18(30)10-8-17)12-19(20)21-5-2-6-22(29-21)26-13-15-3-1-4-16(25)11-15/h1-6,11-12,14,17-18,30H,7-10,13H2,(H,26,29)(H,27,28)/t17-,18- LGFPZWGLLKWJSW-IYARVYRRSA-N 126304 US8778951, 114 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126304&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937083 225152663 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256220 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@@H](CC3)N3CCCCC3)ncc2Cl)c1 InChI=1S/C28H33ClFN5/c29-25-19-32-28(33-22-10-12-23(13-11-22)35-14-2-1-3-15-35)17-24(25)26-8-5-9-27(34-26)31-18-20-6-4-7-21(30)16-20/h4-9,16-17,19,22-23H,1-3,10-15,18H2,(H,31,34)(H,32,33)/t22-,23- HNPFUCWRBTYHNF-YHBQERECSA-N 126305 US8778951, 115 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126305&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405608 225152664 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256221 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncc2Cl)c1 InChI=1S/C27H31ClFN5O/c28-24-18-31-27(32-21-7-9-22(10-8-21)34-11-13-35-14-12-34)16-23(24)25-5-2-6-26(33-25)30-17-19-3-1-4-20(29)15-19/h1-6,15-16,18,21-22H,7-14,17H2,(H,30,33)(H,31,32)/t21-,22- JMELKYOPMXBOKQ-HZCBDIJESA-N 126306 US8778951, 116 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126306&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793991 225152665 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256222 NCCNc1cccc(n1)-c1cc(N[C@H]2CC[C@H](O)CC2)ncc1Cl InChI=1S/C18H24ClN5O/c19-15-11-22-18(23-12-4-6-13(25)7-5-12)10-14(15)16-2-1-3-17(24-16)21-9-8-20/h1-3,10-13,25H,4-9,20H2,(H,21,24)(H,22,23)/t12-,13- OJGZYVWJKNMWCA-JOCQHMNTSA-N 126307 US8778951, 117 Cyclin-T1 Homo sapiens 0.123719173 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126307&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405617 225152666 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256223 NCCCNc1cccc(n1)-c1cc(N[C@H]2CC[C@H](O)CC2)ncc1Cl InChI=1S/C19H26ClN5O/c20-16-12-23-19(24-13-5-7-14(26)8-6-13)11-15(16)17-3-1-4-18(25-17)22-10-2-9-21/h1,3-4,11-14,26H,2,5-10,21H2,(H,22,25)(H,23,24)/t13-,14- DYUCGAGOCTWSRU-HDJSIYSDSA-N 126308 US8778951, 118 Cyclin-T1 Homo sapiens 0.138887135 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126308&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405534 225152667 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256224 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCNCC2)n1 InChI=1S/C22H30ClN5O/c23-19-14-26-22(27-16-4-6-17(29)7-5-16)12-18(19)20-2-1-3-21(28-20)25-13-15-8-10-24-11-9-15/h1-3,12,14-17,24,29H,4-11,13H2,(H,25,28)(H,26,27)/t16-,17- BPYNKWMURHAWBV-QAQDUYKDSA-N 126309 US8778951, 119 Cyclin-T1 Homo sapiens 0.154521231 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126309&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793972 225152668 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256225 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccnc2)n1 InChI=1S/C22H24ClN5O/c23-19-14-26-22(27-16-6-8-17(29)9-7-16)11-18(19)20-4-1-5-21(28-20)25-13-15-3-2-10-24-12-15/h1-5,10-12,14,16-17,29H,6-9,13H2,(H,25,28)(H,26,27)/t16-,17- AXYYFWJWWZJDMP-QAQDUYKDSA-N 126310 US8778951, 120 Cyclin-T1 Homo sapiens 0.045604039 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126310&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405482 225152669 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256226 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@H]2CCCNC2)n1 InChI=1S/C22H30ClN5O/c23-19-14-26-22(27-16-6-8-17(29)9-7-16)11-18(19)20-4-1-5-21(28-20)25-13-15-3-2-10-24-12-15/h1,4-5,11,14-17,24,29H,2-3,6-10,12-13H2,(H,25,28)(H,26,27)/t15-,16-,17-/m0/s1 MDHNKWXSQVMZGA-ULQDDVLXSA-N 126311 US8778951, 121 Cyclin-T1 Homo sapiens 10.49437327 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126311&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793993 225152670 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256227 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccncc2)n1 InChI=1S/C22H24ClN5O/c23-19-14-26-22(27-16-4-6-17(29)7-5-16)12-18(19)20-2-1-3-21(28-20)25-13-15-8-10-24-11-9-15/h1-3,8-12,14,16-17,29H,4-7,13H2,(H,25,28)(H,26,27)/t16-,17- ZVEWJHQALVGDDD-QAQDUYKDSA-N 126312 US8778951, 122 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126312&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794017 225152671 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256228 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@@H]2CCCNC2)n1 InChI=1S/C22H30ClN5O/c23-19-14-26-22(27-16-6-8-17(29)9-7-16)11-18(19)20-4-1-5-21(28-20)25-13-15-3-2-10-24-12-15/h1,4-5,11,14-17,24,29H,2-3,6-10,12-13H2,(H,25,28)(H,26,27)/t15-,16-,17-/m1/s1 MDHNKWXSQVMZGA-BRWVUGGUSA-N 126313 US8778951, 123 Cyclin-T1 Homo sapiens 0.042845475 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126313&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405613 225152672 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256229 CC(=O)NCCNc1cccc(n1)-c1cc(N[C@H]2CC[C@H](O)CC2)ncc1Cl InChI=1S/C20H26ClN5O2/c1-13(27)22-9-10-23-19-4-2-3-18(26-19)16-11-20(24-12-17(16)21)25-14-5-7-15(28)8-6-14/h2-4,11-12,14-15,28H,5-10H2,1H3,(H,22,27)(H,23,26)(H,24,25)/t14-,15- RCTVIHMKPJZYKZ-SHTZXODSSA-N 126314 US8778951, 124 Cyclin-T1 Homo sapiens 0.116276412 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126314&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405066 225152673 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256230 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@H]2CCCO2)n1 InChI=1S/C21H27ClN4O2/c22-18-13-24-21(25-14-6-8-15(27)9-7-14)11-17(18)19-4-1-5-20(26-19)23-12-16-3-2-10-28-16/h1,4-5,11,13-16,27H,2-3,6-10,12H2,(H,23,26)(H,24,25)/t14-,15-,16-/m1/s1 IFQXFKKTDOBYBO-BZUAXINKSA-N 126315 US8778951, 125 Cyclin-T1 Homo sapiens 0.278772642 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126315&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793971 225152674 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256231 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C22H29ClN4O2/c23-19-14-25-22(26-16-4-6-17(28)7-5-16)12-18(19)20-2-1-3-21(27-20)24-13-15-8-10-29-11-9-15/h1-3,12,14-17,28H,4-11,13H2,(H,24,27)(H,25,26)/t16-,17- OAIFWLDGIQRRMJ-QAQDUYKDSA-N 126316 US8778951, 126 Cyclin-T1 Homo sapiens 0.033296354 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126316&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793956 225152675 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256232 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@@H]2CCCO2)n1 InChI=1S/C21H27ClN4O2/c22-18-13-24-21(25-14-6-8-15(27)9-7-14)11-17(18)19-4-1-5-20(26-19)23-12-16-3-2-10-28-16/h1,4-5,11,13-16,27H,2-3,6-10,12H2,(H,23,26)(H,24,25)/t14-,15-,16-/m0/s1 IFQXFKKTDOBYBO-JYJNAYRXSA-N 126317 US8778951, 127 Cyclin-T1 Homo sapiens 0.139053728 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126317&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794047 225152676 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256233 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCCOC2)n1 InChI=1S/C22H29ClN4O2/c23-19-13-25-22(26-16-6-8-17(28)9-7-16)11-18(19)20-4-1-5-21(27-20)24-12-15-3-2-10-29-14-15/h1,4-5,11,13,15-17,28H,2-3,6-10,12,14H2,(H,24,27)(H,25,26)/t15?,16-,17- XJYNNRFFUUQEFR-ATBAIXNZSA-N 126318 US8778951, 128 Cyclin-T1 Homo sapiens 0.033364795 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126318&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793973 225152677 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256234 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC2CCOCC2)n1 InChI=1S/C21H27ClN4O2/c22-18-13-23-21(25-14-4-6-16(27)7-5-14)12-17(18)19-2-1-3-20(26-19)24-15-8-10-28-11-9-15/h1-3,12-16,27H,4-11H2,(H,23,25)(H,24,26)/t14-,16- XDZCBOJGXFYBAM-KOMQPUFPSA-N 126319 US8778951, 129 Cyclin-T1 Homo sapiens 0.390099615 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126319&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794021 225152678 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256235 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(n1)N1CCC(O)CC1 InChI=1S/C21H27ClN4O2/c22-18-13-23-20(24-14-4-6-15(27)7-5-14)12-17(18)19-2-1-3-21(25-19)26-10-8-16(28)9-11-26/h1-3,12-16,27-28H,4-11H2,(H,23,24)/t14-,15- OBHHVHGNRVNRDI-SHTZXODSSA-N 126320 US8778951, 130 Cyclin-T1 Homo sapiens 0.16902747 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126320&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793992 225152679 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256236 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(n1)N1CCOCC1 InChI=1S/C20H25ClN4O2/c21-17-13-22-19(23-14-4-6-15(26)7-5-14)12-16(17)18-2-1-3-20(24-18)25-8-10-27-11-9-25/h1-3,12-15,26H,4-11H2,(H,22,23)/t14-,15- INSHHFZSDSQXNQ-SHTZXODSSA-N 126321 US8778951, 131 Cyclin-T1 Homo sapiens 0.46977199 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126321&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794046 225152680 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256237 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCCCC2)n1 InChI=1S/C23H31ClN4O/c24-20-15-26-23(27-17-9-11-18(29)12-10-17)13-19(20)21-7-4-8-22(28-21)25-14-16-5-2-1-3-6-16/h4,7-8,13,15-18,29H,1-3,5-6,9-12,14H2,(H,25,28)(H,26,27)/t17-,18- GOGMFVUZNOUZHP-IYARVYRRSA-N 126322 US8778951, 132 Cyclin-T1 Homo sapiens 0.014431175 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126322&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794045 225152681 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256238 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C23H23ClF2N4O/c24-20-13-28-23(29-17-4-6-18(31)7-5-17)11-19(20)21-2-1-3-22(30-21)27-12-14-8-15(25)10-16(26)9-14/h1-3,8-11,13,17-18,31H,4-7,12H2,(H,27,30)(H,28,29)/t17-,18- QVDDCLUIXUJBOX-IYARVYRRSA-N 126323 US8778951, 133 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126323&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936961 225152682 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256239 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2ccc(F)cc2)n1 InChI=1S/C23H24ClFN4O/c24-20-14-27-23(28-17-8-10-18(30)11-9-17)12-19(20)21-2-1-3-22(29-21)26-13-15-4-6-16(25)7-5-15/h1-7,12,14,17-18,30H,8-11,13H2,(H,26,29)(H,27,28)/t17-,18- DWAYMOWXPJIKHM-IYARVYRRSA-N 126324 US8778951, 134 Cyclin-T1 Homo sapiens 0.01051692 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126324&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794020 225152683 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256240 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2COCCO2)n1 InChI=1S/C21H27ClN4O3/c22-18-12-24-21(25-14-4-6-15(27)7-5-14)10-17(18)19-2-1-3-20(26-19)23-11-16-13-28-8-9-29-16/h1-3,10,12,14-16,27H,4-9,11,13H2,(H,23,26)(H,24,25)/t14-,15-,16? SCWLOTBJHDFERM-MRJYIUEKSA-N 126325 US8778951, 135 Cyclin-T1 Homo sapiens 0.142053718 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126325&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793953 225152684 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256241 NCC1CCN(CC1)c1cccc(n1)-c1cc(N[C@H]2CC[C@H](O)CC2)ncc1Cl InChI=1S/C22H30ClN5O/c23-19-14-25-21(26-16-4-6-17(29)7-5-16)12-18(19)20-2-1-3-22(27-20)28-10-8-15(13-24)9-11-28/h1-3,12,14-17,29H,4-11,13,24H2,(H,25,26)/t16-,17- UGLJPEADADUIST-QAQDUYKDSA-N 126326 US8778951, 136 Cyclin-T1 Homo sapiens 0.204223958 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126326&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405076 225152685 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256242 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(N)c(NCc2cccc(F)c2)n1 InChI=1S/C23H26ClFN6/c24-19-13-28-22(30-17-6-4-16(26)5-7-17)11-18(19)21-9-8-20(27)23(31-21)29-12-14-2-1-3-15(25)10-14/h1-3,8-11,13,16-17H,4-7,12,26-27H2,(H,28,30)(H,29,31)/t16-,17- WOGARJHWDVFAEE-QAQDUYKDSA-N 126200 US8778951, 10::US8778951, 137 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126200&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405063 225152561 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256243 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(C(N)=O)c(NCc2cccc(F)c2)n1 InChI=1S/C24H26ClFN6O/c25-20-13-29-22(31-17-6-4-16(27)5-7-17)11-19(20)21-9-8-18(23(28)33)24(32-21)30-12-14-2-1-3-15(26)10-14/h1-3,8-11,13,16-17H,4-7,12,27H2,(H2,28,33)(H,29,31)(H,30,32)/t16-,17- ZMZAKBCAMLVUNN-QAQDUYKDSA-N 126328 US8778951, 138 Cyclin-T1 Homo sapiens 0.521640084 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126328&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937219 225152687 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256244 N[C@H]1CC[C@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H25ClFN5/c24-20-14-28-23(29-18-9-7-17(26)8-10-18)12-19(20)21-5-2-6-22(30-21)27-13-15-3-1-4-16(25)11-15/h1-6,11-12,14,17-18H,7-10,13,26H2,(H,27,30)(H,28,29)/t17-,18+ XKHXPTSUVPZYDW-HDICACEKSA-N 126329 US8778951, 139 Cyclin-T1 Homo sapiens 0.030140062 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126329&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 49855228 225152688 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256245 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCCC3)ncc2Cl)c1 InChI=1S/C22H22ClFN4/c23-19-14-26-22(27-17-7-1-2-8-17)12-18(19)20-9-4-10-21(28-20)25-13-15-5-3-6-16(24)11-15/h3-6,9-12,14,17H,1-2,7-8,13H2,(H,25,28)(H,26,27) CDELJPQCNKRZAI-UHFFFAOYSA-N 126330 US8778951, 140 Cyclin-T1 Homo sapiens 0.012553271 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126330&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405150 225152689 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256246 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCCCC3)ncc2Cl)c1 InChI=1S/C23H24ClFN4/c24-20-15-27-23(28-18-8-2-1-3-9-18)13-19(20)21-10-5-11-22(29-21)26-14-16-6-4-7-17(25)12-16/h4-7,10-13,15,18H,1-3,8-9,14H2,(H,26,29)(H,27,28) FPLCTKFXLONEEC-UHFFFAOYSA-N 126331 US8778951, 141 Cyclin-T1 Homo sapiens 0.204786235 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126331&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405148 225152690 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256247 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCOCC3)ncc2Cl)c1 InChI=1S/C22H22ClFN4O/c23-19-14-26-22(27-17-7-9-29-10-8-17)12-18(19)20-5-2-6-21(28-20)25-13-15-3-1-4-16(24)11-15/h1-6,11-12,14,17H,7-10,13H2,(H,25,28)(H,26,27) JCOMZLXSXWGRNX-UHFFFAOYSA-N 126332 US8778951, 142 Cyclin-T1 Homo sapiens 0.025611049 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126332&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794022 225152691 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256248 Fc1cccc(CNc2cccc(n2)-c2cc(NCC3CCOCC3)ncc2Cl)c1 InChI=1S/C23H24ClFN4O/c24-20-15-28-23(27-13-16-7-9-30-10-8-16)12-19(20)21-5-2-6-22(29-21)26-14-17-3-1-4-18(25)11-17/h1-6,11-12,15-16H,7-10,13-14H2,(H,26,29)(H,27,28) XZJZDLMWZMVCDF-UHFFFAOYSA-N 126333 US8778951, 143 Cyclin-T1 Homo sapiens 0.022738812 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126333&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405077 225152692 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256249 NCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C20H21ClFN5/c21-17-13-26-20(24-9-3-8-23)11-16(17)18-6-2-7-19(27-18)25-12-14-4-1-5-15(22)10-14/h1-2,4-7,10-11,13H,3,8-9,12,23H2,(H,24,26)(H,25,27) HSNCMNDQBZCZLC-UHFFFAOYSA-N 126334 US8778951, 144 Cyclin-T1 Homo sapiens 0.015810302 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126334&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405081 225152693 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256250 NCCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C21H23ClFN5/c22-18-14-27-21(25-10-2-1-9-24)12-17(18)19-7-4-8-20(28-19)26-13-15-5-3-6-16(23)11-15/h3-8,11-12,14H,1-2,9-10,13,24H2,(H,25,27)(H,26,28) LLHPYWGXJMMCLB-UHFFFAOYSA-N 126335 US8778951, 145 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126335&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405535 225152694 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256251 OCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C20H20ClFN4O/c21-17-13-25-20(23-8-3-9-27)11-16(17)18-6-2-7-19(26-18)24-12-14-4-1-5-15(22)10-14/h1-2,4-7,10-11,13,27H,3,8-9,12H2,(H,23,25)(H,24,26) FDSQATWCNNIXSC-UHFFFAOYSA-N 126336 US8778951, 146 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126336&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405082 225152695 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256252 COCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C21H22ClFN4O/c1-28-10-4-9-24-21-12-17(18(22)14-26-21)19-7-3-8-20(27-19)25-13-15-5-2-6-16(23)11-15/h2-3,5-8,11-12,14H,4,9-10,13H2,1H3,(H,24,26)(H,25,27) XDGJQWMWGCXACH-UHFFFAOYSA-N 126337 US8778951, 147 Cyclin-T1 Homo sapiens 0.019350577 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126337&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405616 225152696 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256253 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@@H]3CCCOC3)ncc2Cl)c1 InChI=1S/C22H22ClFN4O/c23-19-13-26-22(27-17-6-3-9-29-14-17)11-18(19)20-7-2-8-21(28-20)25-12-15-4-1-5-16(24)10-15/h1-2,4-5,7-8,10-11,13,17H,3,6,9,12,14H2,(H,25,28)(H,26,27)/t17-/m1/s1 QFBJHWFOTMVPDR-QGZVFWFLSA-N 126338 US8778951, 148 Cyclin-T1 Homo sapiens 15.62589296 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126338&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793955 225152697 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256254 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCC(F)(F)CC3)ncc2Cl)c1 InChI=1S/C23H22ClF3N4/c24-19-14-29-22(30-17-7-9-23(26,27)10-8-17)12-18(19)20-5-2-6-21(31-20)28-13-15-3-1-4-16(25)11-15/h1-6,11-12,14,17H,7-10,13H2,(H,28,31)(H,29,30) RMFSLIZWWDQLNX-UHFFFAOYSA-N 126339 US8778951, 149 Cyclin-T1 Homo sapiens 0.516196192 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126339&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793994 225152698 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256255 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CCCOC3)ncc2Cl)c1 InChI=1S/C22H22ClFN4O/c23-19-13-26-22(27-17-6-3-9-29-14-17)11-18(19)20-7-2-8-21(28-20)25-12-15-4-1-5-16(24)10-15/h1-2,4-5,7-8,10-11,13,17H,3,6,9,12,14H2,(H,25,28)(H,26,27)/t17-/m0/s1 QFBJHWFOTMVPDR-KRWDZBQOSA-N 126340 US8778951, 150 Cyclin-T1 Homo sapiens 6.512117546 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126340&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405071 225152699 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256256 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@@H](CC3)N3CCCC3)ncc2Cl)c1 InChI=1S/C27H31ClFN5/c28-24-18-31-27(32-21-9-11-22(12-10-21)34-13-1-2-14-34)16-23(24)25-7-4-8-26(33-25)30-17-19-5-3-6-20(29)15-19/h3-8,15-16,18,21-22H,1-2,9-14,17H2,(H,30,33)(H,31,32)/t21-,22- WBXQTOAEMJUHSE-HZCBDIJESA-N 126341 US8778951, 151 Cyclin-T1 Homo sapiens 0.007945668 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126341&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405603 225152700 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256257 C[C@H]1C[C@H](CC[C@@H]1N)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H27ClFN5/c1-15-10-18(8-9-21(15)27)30-24-12-19(20(25)14-29-24)22-6-3-7-23(31-22)28-13-16-4-2-5-17(26)11-16/h2-7,11-12,14-15,18,21H,8-10,13,27H2,1H3,(H,28,31)(H,29,30)/t15-,18-,21-/m0/s1 FAQDLUFLXPAFMS-XERREHJYSA-N 126342 US8778951, 152 Cyclin-T1 Homo sapiens 0.027 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126342&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405480 225152701 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256258 N[C@H]1CCCC[C@H]1Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H25ClFN5/c24-18-14-28-23(30-21-8-2-1-7-19(21)26)12-17(18)20-9-4-10-22(29-20)27-13-15-5-3-6-16(25)11-15/h3-6,9-12,14,19,21H,1-2,7-8,13,26H2,(H,27,29)(H,28,30)/t19-,21+/m0/s1 WWICCEMXRFMRFH-PZJWPPBQSA-N 126343 US8778951, 153 Cyclin-T1 Homo sapiens 1.546 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126343&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405538 225152702 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256259 O[C@H]1CCCC[C@H]1Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O/c24-18-14-27-23(29-20-7-1-2-9-21(20)30)12-17(18)19-8-4-10-22(28-19)26-13-15-5-3-6-16(25)11-15/h3-6,8,10-12,14,20-21,30H,1-2,7,9,13H2,(H,26,28)(H,27,29)/t20-,21+/m1/s1 ZPFQTSCOCHSZMH-RTWAWAEBSA-N 126344 US8778951, 154 Cyclin-T1 Homo sapiens 0.382 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126344&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405492 225152703 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256260 CCOC(=O)c1coc(N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCc3cccc(F)c3)n2)n1 InChI=1S/C29H30ClFN6O3/c1-2-39-28(38)25-17-40-29(37-25)35-21-11-9-20(10-12-21)34-27-14-22(23(30)16-33-27)24-7-4-8-26(36-24)32-15-18-5-3-6-19(31)13-18/h3-8,13-14,16-17,20-21H,2,9-12,15H2,1H3,(H,32,36)(H,33,34)(H,35,37)/t20-,21- VJULEFTVJPIALU-MEMLXQNLSA-N 126345 US8778951, 155 Cyclin-T1 Homo sapiens 0.023 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126345&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936954 225152704 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256261 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@@H](CC3)Nc3cc(Cl)ncn3)ncc2Cl)c1 InChI=1S/C27H26Cl2FN7/c28-22-15-32-26(35-19-7-9-20(10-8-19)36-27-13-24(29)33-16-34-27)12-21(22)23-5-2-6-25(37-23)31-14-17-3-1-4-18(30)11-17/h1-6,11-13,15-16,19-20H,7-10,14H2,(H,31,37)(H,32,35)(H,33,34,36)/t19-,20- NJZOIYIHLMHFQT-MXVIHJGJSA-N 126346 US8778951, 156 Cyclin-T1 Homo sapiens 0.045 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126346&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 86766525 225152705 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256262 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C26H31ClFN5O/c1-34-13-12-29-20-8-10-21(11-9-20)32-26-15-22(23(27)17-31-26)24-6-3-7-25(33-24)30-16-18-4-2-5-19(28)14-18/h2-7,14-15,17,20-21,29H,8-13,16H2,1H3,(H,30,33)(H,31,32)/t20-,21- RYNSPDQMLLMRGE-MEMLXQNLSA-N 126347 US8778951, 157 Cyclin-T1 Homo sapiens 0.0079 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126347&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906615 225152706 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256263 CN1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C28H34ClFN6/c1-35-12-14-36(15-13-35)23-10-8-22(9-11-23)33-28-17-24(25(29)19-32-28)26-6-3-7-27(34-26)31-18-20-4-2-5-21(30)16-20/h2-7,16-17,19,22-23H,8-15,18H2,1H3,(H,31,34)(H,32,33)/t22-,23- YSHWOQYUAQHGEL-YHBQERECSA-N 126348 US8778951, 158 Cyclin-T1 Homo sapiens 0.011 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126348&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405483 225152707 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256264 NCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C19H19ClFN5/c20-16-12-25-19(23-8-7-22)10-15(16)17-5-2-6-18(26-17)24-11-13-3-1-4-14(21)9-13/h1-6,9-10,12H,7-8,11,22H2,(H,23,25)(H,24,26) ZSCIJBCENWKQKZ-UHFFFAOYSA-N 126349 US8778951, 159 Cyclin-T1 Homo sapiens 1.383 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126349&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793995 225152708 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256172 Fc1cncc(CNc2cccc(n2)-c2cc(NC3CCNCC3)ncc2Cl)c1 InChI=1S/C21H22ClFN6/c22-18-13-27-21(28-16-4-6-24-7-5-16)9-17(18)19-2-1-3-20(29-19)26-11-14-8-15(23)12-25-10-14/h1-3,8-10,12-13,16,24H,4-7,11H2,(H,26,29)(H,27,28) SIWXGYPJSJONQU-UHFFFAOYSA-N 126257 US8778951, 67 Cyclin-T1 Homo sapiens 2.550202 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126257&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405491 225152616 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256265 OCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C19H18ClFN4O/c20-16-12-24-19(22-7-8-26)10-15(16)17-5-2-6-18(25-17)23-11-13-3-1-4-14(21)9-13/h1-6,9-10,12,26H,7-8,11H2,(H,22,24)(H,23,25) FRNJGLWAJAIZJW-UHFFFAOYSA-N 126350 US8778951, 160 Cyclin-T1 Homo sapiens 0.019 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126350&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405342 225152709 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256266 CN(C)CCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H27ClFN5/c1-30(2)12-4-3-11-26-23-14-19(20(24)16-28-23)21-9-6-10-22(29-21)27-15-17-7-5-8-18(25)13-17/h5-10,13-14,16H,3-4,11-12,15H2,1-2H3,(H,26,28)(H,27,29) CRRZXWCMQDWIAH-UHFFFAOYSA-N 126351 US8778951, 161 Cyclin-T1 Homo sapiens 0.026 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126351&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405341 225152710 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256267 Fc1cccc(CNc2cccc(n2)-c2cc(NCC3CCNCC3)ncc2Cl)c1 InChI=1S/C23H25ClFN5/c24-20-15-29-23(28-13-16-7-9-26-10-8-16)12-19(20)21-5-2-6-22(30-21)27-14-17-3-1-4-18(25)11-17/h1-6,11-12,15-16,26H,7-10,13-14H2,(H,27,30)(H,28,29) UKTVSCYMCGSVBK-UHFFFAOYSA-N 126352 US8778951, 162 Cyclin-T1 Homo sapiens 0.014 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126352&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405344 225152711 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256268 CN1CCC(CNc2cc(c(Cl)cn2)-c2cccc(NCc3cccc(F)c3)n2)CC1 InChI=1S/C24H27ClFN5/c1-31-10-8-17(9-11-31)14-28-24-13-20(21(25)16-29-24)22-6-3-7-23(30-22)27-15-18-4-2-5-19(26)12-18/h2-7,12-13,16-17H,8-11,14-15H2,1H3,(H,27,30)(H,28,29) OCLCFSKYPHBYFB-UHFFFAOYSA-N 126353 US8778951, 163 Cyclin-T1 Homo sapiens 0.013 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126353&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405343 225152712 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256269 Fc1cccc(CNc2cccc(n2)-c2cc(NCC3CCCNC3)ncc2Cl)c1 InChI=1S/C23H25ClFN5/c24-20-15-29-23(28-14-17-5-3-9-26-12-17)11-19(20)21-7-2-8-22(30-21)27-13-16-4-1-6-18(25)10-16/h1-2,4,6-8,10-11,15,17,26H,3,5,9,12-14H2,(H,27,30)(H,28,29) JMLIIFDVZSUSAB-UHFFFAOYSA-N 126354 US8778951, 164::US8778951, 166 Cyclin-T1 Homo sapiens 0.039 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126354&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 77488936 225152713 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256270 Fc1cccc(CNc2cccc(n2)-c2cc(NCC[C@H]3CCCNC3)ncc2Cl)c1 InChI=1S/C24H27ClFN5/c25-21-16-30-24(28-11-9-17-5-3-10-27-14-17)13-20(21)22-7-2-8-23(31-22)29-15-18-4-1-6-19(26)12-18/h1-2,4,6-8,12-13,16-17,27H,3,5,9-11,14-15H2,(H,28,30)(H,29,31)/t17-/m1/s1 IXVQBXGAKSATOK-QGZVFWFLSA-N 126355 US8778951, 165 Cyclin-T1 Homo sapiens 0.0079 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126355&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936931 225152714 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256271 Fc1cccc(CNc2cccc(n2)-c2cc(NCC3CCCNC3)ncc2Cl)c1 InChI=1S/C23H25ClFN5/c24-20-15-29-23(28-14-17-5-3-9-26-12-17)11-19(20)21-7-2-8-22(30-21)27-13-16-4-1-6-18(25)10-16/h1-2,4,6-8,10-11,15,17,26H,3,5,9,12-14H2,(H,27,30)(H,28,29) JMLIIFDVZSUSAB-UHFFFAOYSA-N 126354 US8778951, 164::US8778951, 166 Cyclin-T1 Homo sapiens 0.027 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126354&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 77488936 225152713 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256272 Fc1cccc(CNc2cccc(n2)-c2cc(NCC[C@@H]3CCCNC3)ncc2Cl)c1 InChI=1S/C24H27ClFN5/c25-21-16-30-24(28-11-9-17-5-3-10-27-14-17)13-20(21)22-7-2-8-23(31-22)29-15-18-4-1-6-19(26)12-18/h1-2,4,6-8,12-13,16-17,27H,3,5,9-11,14-15H2,(H,28,30)(H,29,31)/t17-/m0/s1 IXVQBXGAKSATOK-KRWDZBQOSA-N 126357 US8778951, 167 Cyclin-T1 Homo sapiens 0.018 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126357&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405621 225152716 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256273 Fc1cccc(CNc2cccc(n2)-c2cc(NCCN3CCNCC3)ncc2Cl)c1 InChI=1S/C23H26ClFN6/c24-20-16-29-23(27-9-12-31-10-7-26-8-11-31)14-19(20)21-5-2-6-22(30-21)28-15-17-3-1-4-18(25)13-17/h1-6,13-14,16,26H,7-12,15H2,(H,27,29)(H,28,30) FKIZIDPBJFGKGP-UHFFFAOYSA-N 126358 US8778951, 168 Cyclin-T1 Homo sapiens 0.037 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126358&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405610 225152717 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256274 N[C@H]1CC[C@H](CNc2cc(c(Cl)cn2)-c2cccc(NCc3cccc(F)c3)n2)CC1 InChI=1S/C24H27ClFN5/c25-21-15-30-24(29-13-16-7-9-19(27)10-8-16)12-20(21)22-5-2-6-23(31-22)28-14-17-3-1-4-18(26)11-17/h1-6,11-12,15-16,19H,7-10,13-14,27H2,(H,28,31)(H,29,30)/t16-,19- UXFSXOGGCBQLHY-RUCARUNLSA-N 126359 US8778951, 169 Cyclin-T1 Homo sapiens 0.009 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126359&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405620 225152718 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256275 CN1CCN(CCNc2cc(c(Cl)cn2)-c2cccc(NCc3cccc(F)c3)n2)CC1 InChI=1S/C24H28ClFN6/c1-31-10-12-32(13-11-31)9-8-27-24-15-20(21(25)17-29-24)22-6-3-7-23(30-22)28-16-18-4-2-5-19(26)14-18/h2-7,14-15,17H,8-13,16H2,1H3,(H,27,29)(H,28,30) TYXPZNRGVHSGJW-UHFFFAOYSA-N 126360 US8778951, 170 Cyclin-T1 Homo sapiens 0.044 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126360&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405629 225152719 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256276 Fc1cccc(CNc2cccc(n2)-c2cc(NCCN3CCOCC3)ncc2Cl)c1 InChI=1S/C23H25ClFN5O/c24-20-16-28-23(26-7-8-30-9-11-31-12-10-30)14-19(20)21-5-2-6-22(29-21)27-15-17-3-1-4-18(25)13-17/h1-6,13-14,16H,7-12,15H2,(H,26,28)(H,27,29) MAFBHBCKBGURJC-UHFFFAOYSA-N 126361 US8778951, 171 Cyclin-T1 Homo sapiens 0.218 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126361&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793996 225152720 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256277 CC(C)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C20H20ClFN4/c1-13(2)25-20-10-16(17(21)12-24-20)18-7-4-8-19(26-18)23-11-14-5-3-6-15(22)9-14/h3-10,12-13H,11H2,1-2H3,(H,23,26)(H,24,25) LIOSFQPVJIUPNZ-UHFFFAOYSA-N 126362 US8778951, 172 Cyclin-T1 Homo sapiens 0.015 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126362&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405533 225152721 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256278 CCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C21H22ClFN4/c1-2-3-10-24-21-12-17(18(22)14-26-21)19-8-5-9-20(27-19)25-13-15-6-4-7-16(23)11-15/h4-9,11-12,14H,2-3,10,13H2,1H3,(H,24,26)(H,25,27) WUOUXPQBFSADPP-UHFFFAOYSA-N 126363 US8778951, 173 Cyclin-T1 Homo sapiens 0.062 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126363&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793997 225152722 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256279 Fc1cccc(CNc2cccc(n2)-c2cc(NCCC3CCOCC3)ncc2Cl)c1 InChI=1S/C24H26ClFN4O/c25-21-16-29-24(27-10-7-17-8-11-31-12-9-17)14-20(21)22-5-2-6-23(30-22)28-15-18-3-1-4-19(26)13-18/h1-6,13-14,16-17H,7-12,15H2,(H,27,29)(H,28,30) PSUPQMBLHOGUQV-UHFFFAOYSA-N 126364 US8778951, 174 Cyclin-T1 Homo sapiens 0.029 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126364&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405544 225152723 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256280 Fc1cccc(CNc2cccc(n2)-c2cc(NCCc3cccnc3)ncc2Cl)c1 InChI=1S/C24H21ClFN5/c25-21-16-30-24(28-11-9-17-5-3-10-27-14-17)13-20(21)22-7-2-8-23(31-22)29-15-18-4-1-6-19(26)12-18/h1-8,10,12-14,16H,9,11,15H2,(H,28,30)(H,29,31) CBCWTKNNPONAEB-UHFFFAOYSA-N 126365 US8778951, 175 Cyclin-T1 Homo sapiens 0.024 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126365&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405622 225152724 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256281 Fc1cccc(CNc2cccc(n2)-c2cc(NCC3CCCOC3)ncc2Cl)c1 InChI=1S/C23H24ClFN4O/c24-20-14-28-23(27-13-17-5-3-9-30-15-17)11-19(20)21-7-2-8-22(29-21)26-12-16-4-1-6-18(25)10-16/h1-2,4,6-8,10-11,14,17H,3,5,9,12-13,15H2,(H,26,29)(H,27,28) MBMUIKSESJDTLI-UHFFFAOYSA-N 126366 US8778951, 176 Cyclin-T1 Homo sapiens 0.021 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126366&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405083 225152725 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256282 Fc1cccc(CNc2cccc(n2)-c2cc(NCCc3ccncc3)ncc2Cl)c1 InChI=1S/C24H21ClFN5/c25-21-16-30-24(28-12-9-17-7-10-27-11-8-17)14-20(21)22-5-2-6-23(31-22)29-15-18-3-1-4-19(26)13-18/h1-8,10-11,13-14,16H,9,12,15H2,(H,28,30)(H,29,31) LIRPBYRFCYVSKQ-UHFFFAOYSA-N 126367 US8778951, 177 Cyclin-T1 Homo sapiens 0.013 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126367&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405487 225152726 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256283 CNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C18H16ClFN4/c1-21-18-9-14(15(19)11-23-18)16-6-3-7-17(24-16)22-10-12-4-2-5-13(20)8-12/h2-9,11H,10H2,1H3,(H,21,23)(H,22,24) ZMTKCBYRPRAYOW-UHFFFAOYSA-N 126368 US8778951, 178 Cyclin-T1 Homo sapiens 0.103 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126368&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937018 225152727 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256284 Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C17H14ClFN4/c18-14-10-21-16(20)8-13(14)15-5-2-6-17(23-15)22-9-11-3-1-4-12(19)7-11/h1-8,10H,9H2,(H2,20,21)(H,22,23) SPAUOSZMLGYUAB-UHFFFAOYSA-N 126369 US8778951, 179 Cyclin-T1 Homo sapiens 0.544 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126369&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127283 225152728 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256286 OC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H26ClFN4O/c25-21-14-28-24(29-19-9-7-16(15-31)8-10-19)12-20(21)22-5-2-6-23(30-22)27-13-17-3-1-4-18(26)11-17/h1-6,11-12,14,16,19,31H,7-10,13,15H2,(H,27,30)(H,28,29)/t16-,19- UDRZVJAHHQGSBI-RUCARUNLSA-N 126371 US8778951, 181 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126371&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937053 225152730 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256287 O[C@H]1CC[C@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O/c24-20-14-27-23(28-17-7-9-18(30)10-8-17)12-19(20)21-5-2-6-22(29-21)26-13-15-3-1-4-16(25)11-15/h1-6,11-12,14,17-18,30H,7-10,13H2,(H,26,29)(H,27,28)/t17-,18+ LGFPZWGLLKWJSW-HDICACEKSA-N 126372 US8778951, 182 Cyclin-T1 Homo sapiens 0.02111 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126372&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937083 225152731 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256288 O[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C22H22ClFN4O/c23-19-13-26-22(27-16-7-8-17(29)10-16)11-18(19)20-5-2-6-21(28-20)25-12-14-3-1-4-15(24)9-14/h1-6,9,11,13,16-17,29H,7-8,10,12H2,(H,25,28)(H,26,27)/t16-,17+/m1/s1 PXLSBJXLXDNYKQ-SJORKVTESA-N 126373 US8778951, 183 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126373&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937090 225152732 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256289 O[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C22H22ClFN4O/c23-19-13-26-22(27-16-7-8-17(29)10-16)11-18(19)20-5-2-6-21(28-20)25-12-14-3-1-4-15(24)9-14/h1-6,9,11,13,16-17,29H,7-8,10,12H2,(H,25,28)(H,26,27)/t16-,17+/m0/s1 PXLSBJXLXDNYKQ-DLBZAZTESA-N 126374 US8778951, 184 Cyclin-T1 Homo sapiens 0.00911 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126374&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405084 225152733 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256290 Fc1cccc(CNc2cccc(n2)-c2cc(NC3CCC=CC3)ncc2Cl)c1 InChI=1S/C23H22ClFN4/c24-20-15-27-23(28-18-8-2-1-3-9-18)13-19(20)21-10-5-11-22(29-21)26-14-16-6-4-7-17(25)12-16/h1-2,4-7,10-13,15,18H,3,8-9,14H2,(H,26,29)(H,27,28) IAIDPHCIWLYXLM-UHFFFAOYSA-N 126375 US8778951, 185 Cyclin-T1 Homo sapiens 0.11048 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126375&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937052 225152734 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256291 OCCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C21H22ClFN4O/c22-18-14-26-21(24-9-1-2-10-28)12-17(18)19-7-4-8-20(27-19)25-13-15-5-3-6-16(23)11-15/h3-8,11-12,14,28H,1-2,9-10,13H2,(H,24,26)(H,25,27) SGALVFVBSHVAIT-UHFFFAOYSA-N 126376 US8778951, 186 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126376&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405542 225152735 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256292 CC(C)(C)OC(=O)CNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O2/c1-23(2,3)31-22(30)14-28-21-11-17(18(24)13-27-21)19-8-5-9-20(29-19)26-12-15-6-4-7-16(25)10-15/h4-11,13H,12,14H2,1-3H3,(H,26,29)(H,27,28) IVLCJDMJTVXCFB-UHFFFAOYSA-N 126377 US8778951, 187 Cyclin-T1 Homo sapiens 2.7386 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126377&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793998 225152736 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256293 NCCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C21H22ClF2N5/c22-18-13-28-21(26-7-2-1-6-25)11-17(18)19-4-3-5-20(29-19)27-12-14-8-15(23)10-16(24)9-14/h3-5,8-11,13H,1-2,6-7,12,25H2,(H,26,28)(H,27,29) LZMOOKCALNXDSH-UHFFFAOYSA-N 126378 US8778951, 188 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126378&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793977 225152737 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256294 OCCCNc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C20H19ClF2N4O/c21-17-12-26-20(24-5-2-6-28)10-16(17)18-3-1-4-19(27-18)25-11-13-7-14(22)9-15(23)8-13/h1,3-4,7-10,12,28H,2,5-6,11H2,(H,24,26)(H,25,27) ILFCGUBLJBDRCR-UHFFFAOYSA-N 126379 US8778951, 189 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126379&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794048 225152738 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256295 COC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H28ClFN4O/c1-32-16-17-8-10-20(11-9-17)30-25-13-21(22(26)15-29-25)23-6-3-7-24(31-23)28-14-18-4-2-5-19(27)12-18/h2-7,12-13,15,17,20H,8-11,14,16H2,1H3,(H,28,31)(H,29,30)/t17-,20- XFVFTZDYWGZRRI-IRJFHVNHSA-N 126380 US8778951, 190 Cyclin-T1 Homo sapiens 0.1 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126380&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794049 225152739 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256296 N[C@@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C22H23ClFN5/c23-19-13-27-22(28-17-8-7-16(25)10-17)11-18(19)20-5-2-6-21(29-20)26-12-14-3-1-4-15(24)9-14/h1-6,9,11,13,16-17H,7-8,10,12,25H2,(H,26,29)(H,27,28)/t16-,17-/m1/s1 ZRWOCTWXOIJUFJ-IAGOWNOFSA-N 126381 US8778951, 191 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126381&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127237 225152740 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256297 N[C@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C22H23ClFN5/c23-19-13-27-22(28-17-8-7-16(25)10-17)11-18(19)20-5-2-6-21(29-20)26-12-14-3-1-4-15(24)9-14/h1-6,9,11,13,16-17H,7-8,10,12,25H2,(H,26,29)(H,27,28)/t16-,17-/m0/s1 ZRWOCTWXOIJUFJ-IRXDYDNUSA-N 126382 US8778951, 192 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126382&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405307 225152741 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256298 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C26H30ClF2N5O/c1-35-10-9-30-20-5-7-21(8-6-20)33-26-14-22(23(27)16-32-26)24-3-2-4-25(34-24)31-15-17-11-18(28)13-19(29)12-17/h2-4,11-14,16,20-21,30H,5-10,15H2,1H3,(H,31,34)(H,32,33)/t20-,21- KDPKNQDJDANEPC-MEMLXQNLSA-N 126383 US8778951, 193 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126383&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906616 225152742 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256299 CO[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H26ClFN4O/c1-31-19-10-8-18(9-11-19)29-24-13-20(21(25)15-28-24)22-6-3-7-23(30-22)27-14-16-4-2-5-17(26)12-16/h2-7,12-13,15,18-19H,8-11,14H2,1H3,(H,27,30)(H,28,29)/t18-,19- CMQVCHIDZHQDIP-WGSAOQKQSA-N 126384 US8778951, 194 Cyclin-T1 Homo sapiens 0.04813 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126384&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405501 225152743 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256300 NCC(O)CNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C20H21ClFN5O/c21-17-12-26-20(25-11-15(28)9-23)8-16(17)18-5-2-6-19(27-18)24-10-13-3-1-4-14(22)7-13/h1-8,12,15,28H,9-11,23H2,(H,24,27)(H,25,26) AFINOCDRNLVVOV-UHFFFAOYSA-N 126385 US8778951, 195 Cyclin-T1 Homo sapiens 0.03556 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126385&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405500 225152744 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256301 OC(=O)CNc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C19H16ClFN4O2/c20-15-10-23-18(24-11-19(26)27)8-14(15)16-5-2-6-17(25-16)22-9-12-3-1-4-13(21)7-12/h1-8,10H,9,11H2,(H,22,25)(H,23,24)(H,26,27) NXPYZEBYDNCXJO-UHFFFAOYSA-N 126386 US8778951, 196 Cyclin-T1 Homo sapiens 0.81167 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126386&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405503 225152745 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256302 N[C@H]1CC[C@@H](CC1)Nc1cc(c(F)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H25F2N5/c24-16-4-1-3-15(11-16)13-27-22-6-2-5-21(30-22)19-12-23(28-14-20(19)25)29-18-9-7-17(26)8-10-18/h1-6,11-12,14,17-18H,7-10,13,26H2,(H,27,30)(H,28,29)/t17-,18- VZGQHJRXPKGKNM-IYARVYRRSA-N 126387 US8778951, 197 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126387&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907429 225152746 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256303 CN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cc(F)cc(F)c2)n1 InChI=1S/C25H28ClF2N5/c1-33(2)20-8-6-19(7-9-20)31-25-13-21(22(26)15-30-25)23-4-3-5-24(32-23)29-14-16-10-17(27)12-18(28)11-16/h3-5,10-13,15,19-20H,6-9,14H2,1-2H3,(H,29,32)(H,30,31)/t19-,20- KVQUQEGZUDMVIL-MXVIHJGJSA-N 126388 US8778951, 198 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126388&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405493 225152747 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256304 COCCN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C27H33ClFN5O/c1-34(13-14-35-2)22-11-9-21(10-12-22)32-27-16-23(24(28)18-31-27)25-7-4-8-26(33-25)30-17-19-5-3-6-20(29)15-19/h3-8,15-16,18,21-22H,9-14,17H2,1-2H3,(H,30,33)(H,31,32)/t21-,22- HVANNVBNCHMPFL-HZCBDIJESA-N 126389 US8778951, 199 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126389&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906617 225152748 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256305 OCCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C26H31ClFN5O/c27-23-17-31-26(32-21-10-8-20(9-11-21)29-12-3-13-34)15-22(23)24-6-2-7-25(33-24)30-16-18-4-1-5-19(28)14-18/h1-2,4-7,14-15,17,20-21,29,34H,3,8-13,16H2,(H,30,33)(H,31,32)/t20-,21- UNCKEGSLTKAWSV-MEMLXQNLSA-N 126390 US8778951, 200 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126390&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405154 225152749 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256306 OC(=O)[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H22ClFN4O2/c24-19-13-27-22(28-17-8-7-15(10-17)23(30)31)11-18(19)20-5-2-6-21(29-20)26-12-14-3-1-4-16(25)9-14/h1-6,9,11,13,15,17H,7-8,10,12H2,(H,26,29)(H,27,28)(H,30,31)/t15-,17+/m1/s1 VRKVOABYTPTBTE-WBVHZDCISA-N 126391 US8778951, 201 Cyclin-T1 Homo sapiens 0.63424 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126391&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794050 225152750 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256307 OC(=O)[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H22ClFN4O2/c24-19-13-27-22(28-17-8-7-15(10-17)23(30)31)11-18(19)20-5-2-6-21(29-20)26-12-14-3-1-4-16(25)9-14/h1-6,9,11,13,15,17H,7-8,10,12H2,(H,26,29)(H,27,28)(H,30,31)/t15-,17+/m0/s1 VRKVOABYTPTBTE-DOTOQJQBSA-N 126392 US8778951, 202 Cyclin-T1 Homo sapiens 0.01884 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126392&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936933 225152751 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256308 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C21H29ClN6O/c22-18-11-26-20(27-16-3-1-15(23)2-4-16)9-17(18)19-12-24-13-21(28-19)25-10-14-5-7-29-8-6-14/h9,11-16H,1-8,10,23H2,(H,25,28)(H,26,27)/t15-,16- SGAITOWYMYEPQN-WKILWMFISA-N 126393 US8778951, 203 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126393&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 60142670 225152752 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256309 CNC(=O)[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H25ClFN5O/c1-27-24(32)16-8-9-18(11-16)30-23-12-19(20(25)14-29-23)21-6-3-7-22(31-21)28-13-15-4-2-5-17(26)10-15/h2-7,10,12,14,16,18H,8-9,11,13H2,1H3,(H,27,32)(H,28,31)(H,29,30)/t16-,18+/m0/s1 WSLITPBXEOZRTH-FUHWJXTLSA-N 126394 US8778951, 204 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126394&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405489 225152753 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256310 CN(C)C(=O)[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H27ClFN5O/c1-32(2)25(33)17-9-10-19(12-17)30-24-13-20(21(26)15-29-24)22-7-4-8-23(31-22)28-14-16-5-3-6-18(27)11-16/h3-8,11,13,15,17,19H,9-10,12,14H2,1-2H3,(H,28,31)(H,29,30)/t17-,19+/m0/s1 BMPBLNCNGMFFDN-PKOBYXMFSA-N 126395 US8778951, 205 Cyclin-T1 Homo sapiens 0.01747 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126395&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127273 225152754 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256311 Clc1cnc(N[C@H]2CC[C@@H](CC2)NC(=O)OCc2ccccc2)cc1-c1cccc(NC[C@H]2CCCNC2)n1 InChI=1S/C30H37ClN6O2/c31-26-19-34-29(16-25(26)27-9-4-10-28(37-27)33-18-22-8-5-15-32-17-22)35-23-11-13-24(14-12-23)36-30(38)39-20-21-6-2-1-3-7-21/h1-4,6-7,9-10,16,19,22-24,32H,5,8,11-15,17-18,20H2,(H,33,37)(H,34,35)(H,36,38)/t22-,23-,24-/m0/s1 JQMGLAQRGYNVCF-HJOGWXRNSA-N 126396 US8778951, 206 Cyclin-T1 Homo sapiens 0.13378 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126396&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937019 225152755 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256312 Clc1cnc(N[C@H]2CC[C@@H](CC2)NC(=O)OCc2ccccc2)cc1-c1cccc(NC[C@@H]2CCCNC2)n1 InChI=1S/C30H37ClN6O2/c31-26-19-34-29(16-25(26)27-9-4-10-28(37-27)33-18-22-8-5-15-32-17-22)35-23-11-13-24(14-12-23)36-30(38)39-20-21-6-2-1-3-7-21/h1-4,6-7,9-10,16,19,22-24,32H,5,8,11-15,17-18,20H2,(H,33,37)(H,34,35)(H,36,38)/t22-,23-,24-/m1/s1 JQMGLAQRGYNVCF-WXFUMESZSA-N 126397 US8778951, 207 Cyclin-T1 Homo sapiens 0.114147 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126397&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405346 225152756 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256313 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C21H28ClN5O2/c22-18-11-25-20(26-15-1-3-16(28)4-2-15)9-17(18)19-12-23-13-21(27-19)24-10-14-5-7-29-8-6-14/h9,11-16,28H,1-8,10H2,(H,24,27)(H,25,26)/t15-,16- BOBBODBDAKNASJ-WKILWMFISA-N 126398 US8778951, 208 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126398&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907431 225152757 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256314 CN1CCC(CNc2cc(c(Cl)cn2)-c2cncc(NCC3CCOCC3)n2)CC1 InChI=1S/C22H31ClN6O/c1-29-6-2-16(3-7-29)11-25-21-10-18(19(23)13-27-21)20-14-24-15-22(28-20)26-12-17-4-8-30-9-5-17/h10,13-17H,2-9,11-12H2,1H3,(H,25,27)(H,26,28) YWXWZWDDMQKBPW-UHFFFAOYSA-N 126399 US8778951, 209 Cyclin-T1 Homo sapiens 0.183 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126399&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405609 225152758 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256315 OCCNc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C17H22ClN5O2/c18-14-9-22-16(20-3-4-24)7-13(14)15-10-19-11-17(23-15)21-8-12-1-5-25-6-2-12/h7,9-12,24H,1-6,8H2,(H,20,22)(H,21,23) OOGWIORWHBOXPZ-UHFFFAOYSA-N 126400 US8778951, 210 Cyclin-T1 Homo sapiens 0.08597 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126400&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405348 225152759 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256316 Cc1cnc(N[C@H]2CC[C@H](N)CC2)cc1-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H28FN5/c1-16-14-27-24(29-20-10-8-19(26)9-11-20)13-21(16)22-6-3-7-23(30-22)28-15-17-4-2-5-18(25)12-17/h2-7,12-14,19-20H,8-11,15,26H2,1H3,(H,27,29)(H,28,30)/t19-,20- QHKILCBNOPPVEQ-MXVIHJGJSA-N 126401 US8778951, 211 Cyclin-T1 Homo sapiens 0.02101 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126401&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936966 225152760 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256317 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(N[C@@H]2CC22CCOCC2)n1 InChI=1S/C23H30ClN5O/c24-18-14-26-22(27-16-6-4-15(25)5-7-16)12-17(18)19-2-1-3-21(28-19)29-20-13-23(20)8-10-30-11-9-23/h1-3,12,14-16,20H,4-11,13,25H2,(H,26,27)(H,28,29)/t15-,16-,20-/m1/s1 QGBWRRYBKYADNK-JXXFODFXSA-N 126402 US8778951, 212 Cyclin-T1 Homo sapiens 0.0546 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126402&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127222 225152761 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256318 Fc1cccc(CNc2cccc(n2)-c2cc(N[C@@H]3CC[C@@H](C3)C(=O)N3CCCC3)ncc2Cl)c1 InChI=1S/C27H29ClFN5O/c28-23-17-31-26(32-21-10-9-19(14-21)27(35)34-11-1-2-12-34)15-22(23)24-7-4-8-25(33-24)30-16-18-5-3-6-20(29)13-18/h3-8,13,15,17,19,21H,1-2,9-12,14,16H2,(H,30,33)(H,31,32)/t19-,21+/m0/s1 AUUXVKVFCTYEOR-PZJWPPBQSA-N 126403 US8778951, 213 Cyclin-T1 Homo sapiens 0.0142 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126403&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405351 225152762 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256319 CNC(=O)[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H25ClFN5O/c1-27-24(32)16-8-9-18(11-16)30-23-12-19(20(25)14-29-23)21-6-3-7-22(31-21)28-13-15-4-2-5-17(26)10-15/h2-7,10,12,14,16,18H,8-9,11,13H2,1H3,(H,27,32)(H,28,31)(H,29,30)/t16-,18+/m1/s1 WSLITPBXEOZRTH-AEFFLSMTSA-N 126404 US8778951, 214 Cyclin-T1 Homo sapiens 0.04169 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126404&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405349 225152763 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256320 CC(=O)N1CCC[C@H](CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)C1 InChI=1S/C24H33ClN6O/c1-16(32)31-11-3-4-17(15-31)13-27-23-6-2-5-22(30-23)20-12-24(28-14-21(20)25)29-19-9-7-18(26)8-10-19/h2,5-6,12,14,17-19H,3-4,7-11,13,15,26H2,1H3,(H,27,30)(H,28,29)/t17-,18-,19-/m1/s1 HTJYHEWVSQAGNH-GUDVDZBRSA-N 126405 US8778951, 215 Cyclin-T1 Homo sapiens 0.06545 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126405&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937036 225152764 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256321 CC(=O)N1CCC[C@H](CNc2cccc(n2)-c2ccnc(N[C@H]3CC[C@H](N)CC3)c2)C1 InChI=1S/C24H34N6O/c1-17(31)30-13-3-4-18(16-30)15-27-23-6-2-5-22(29-23)19-11-12-26-24(14-19)28-21-9-7-20(25)8-10-21/h2,5-6,11-12,14,18,20-21H,3-4,7-10,13,15-16,25H2,1H3,(H,26,28)(H,27,29)/t18-,20-,21-/m1/s1 FIPYZRSECMCPGI-HMXCVIKNSA-N 126406 US8778951, 216 Cyclin-T1 Homo sapiens 0.13825 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126406&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936948 225152765 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256322 CC(=O)N1CCC[C@@H](CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)C1 InChI=1S/C24H33ClN6O/c1-16(32)31-11-3-4-17(15-31)13-27-23-6-2-5-22(30-23)20-12-24(28-14-21(20)25)29-19-9-7-18(26)8-10-19/h2,5-6,12,14,17-19H,3-4,7-11,13,15,26H2,1H3,(H,27,30)(H,28,29)/t17-,18-,19-/m0/s1 HTJYHEWVSQAGNH-FHWLQOOXSA-N 126407 US8778951, 217 Cyclin-T1 Homo sapiens 0.03728 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126407&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405624 225152766 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256323 CC(=O)N1CCC[C@@H](CNc2cccc(n2)-c2ccnc(N[C@H]3CC[C@H](N)CC3)c2)C1 InChI=1S/C24H34N6O/c1-17(31)30-13-3-4-18(16-30)15-27-23-6-2-5-22(29-23)19-11-12-26-24(14-19)28-21-9-7-20(25)8-10-21/h2,5-6,11-12,14,18,20-21H,3-4,7-10,13,15-16,25H2,1H3,(H,26,28)(H,27,29)/t18-,20-,21-/m0/s1 FIPYZRSECMCPGI-JBACZVJFSA-N 126408 US8778951, 218 Cyclin-T1 Homo sapiens 0.12766 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126408&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405625 225152767 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256324 OC[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O/c24-20-13-27-23(28-18-8-7-16(10-18)14-30)11-19(20)21-5-2-6-22(29-21)26-12-15-3-1-4-17(25)9-15/h1-6,9,11,13,16,18,30H,7-8,10,12,14H2,(H,26,29)(H,27,28)/t16-,18+/m1/s1 WYFAZTRPKZXXEC-AEFFLSMTSA-N 126409 US8778951, 219 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126409&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405632 225152768 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256325 OC[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H24ClFN4O/c24-20-13-27-23(28-18-8-7-16(10-18)14-30)11-19(20)21-5-2-6-22(29-21)26-12-15-3-1-4-17(25)9-15/h1-6,9,11,13,16,18,30H,7-8,10,12,14H2,(H,26,29)(H,27,28)/t16-,18+/m0/s1 WYFAZTRPKZXXEC-FUHWJXTLSA-N 126410 US8778951, 220 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126410&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937105 225152769 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256326 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(Cl)c(NCC2CCOCC2)n1 InChI=1S/C21H28Cl2N6O/c22-17-11-25-19(28-15-3-1-14(24)2-4-15)9-16(17)18-12-26-20(23)21(29-18)27-10-13-5-7-30-8-6-13/h9,11-15H,1-8,10,24H2,(H,25,28)(H,27,29)/t14-,15- CGHMDIRNKZECHG-SHTZXODSSA-N 126411 US8778951, 221 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126411&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907028 225152770 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256327 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(Cl)c(NCC2CCOCC2)n1 InChI=1S/C21H27Cl2N5O2/c22-17-11-24-19(27-14-1-3-15(29)4-2-14)9-16(17)18-12-25-20(23)21(28-18)26-10-13-5-7-30-8-6-13/h9,11-15,29H,1-8,10H2,(H,24,27)(H,26,28)/t14-,15- SZNFKBXAVWZDFT-SHTZXODSSA-N 126412 US8778951, 222 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126412&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907220 225152771 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256328 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)cnc1Cl InChI=1S/C21H28Cl2N6O/c22-17-11-26-18(28-15-3-1-14(24)2-4-15)9-16(17)20-21(23)27-12-19(29-20)25-10-13-5-7-30-8-6-13/h9,11-15H,1-8,10,24H2,(H,25,29)(H,26,28)/t14-,15- CBTXUDOZDSTTCZ-SHTZXODSSA-N 126413 US8778951, 223 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126413&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907426 225152772 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256329 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(C(N)=O)c(NCC2CCOCC2)n1 InChI=1S/C22H30ClN7O2/c23-17-11-26-19(29-15-3-1-14(24)2-4-15)9-16(17)18-12-27-20(21(25)31)22(30-18)28-10-13-5-7-32-8-6-13/h9,11-15H,1-8,10,24H2,(H2,25,31)(H,26,29)(H,28,30)/t14-,15- ZAEIYTFBEOFDOU-SHTZXODSSA-N 126414 US8778951, 224 Cyclin-T1 Homo sapiens 0.091885 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126414&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937095 225152773 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256330 Clc1cnc(N[C@H]2CC[C@@H](CC2)N2CCCC2)cc1-c1cnc(Cl)c(NCC2CCOCC2)n1 InChI=1S/C25H34Cl2N6O/c26-21-15-28-23(31-18-3-5-19(6-4-18)33-9-1-2-10-33)13-20(21)22-16-29-24(27)25(32-22)30-14-17-7-11-34-12-8-17/h13,15-19H,1-12,14H2,(H,28,31)(H,30,32)/t18-,19- RNJINBPTJIKQAX-WGSAOQKQSA-N 126415 US8778951, 225 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126415&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127064 225152774 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256331 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(N)c(NCC2CCOCC2)n1 InChI=1S/C21H30ClN7O/c22-17-11-25-19(28-15-3-1-14(23)2-4-15)9-16(17)18-12-26-20(24)21(29-18)27-10-13-5-7-30-8-6-13/h9,11-15H,1-8,10,23H2,(H2,24,26)(H,25,28)(H,27,29)/t14-,15- YGYLVJRYDVLWGK-SHTZXODSSA-N 126416 US8778951, 226 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126416&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127084 225152775 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256332 Nc1ncc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@H](O)CC2)ncc1Cl InChI=1S/C21H29ClN6O2/c22-17-11-24-19(27-14-1-3-15(29)4-2-14)9-16(17)18-12-25-20(23)21(28-18)26-10-13-5-7-30-8-6-13/h9,11-15,29H,1-8,10H2,(H2,23,25)(H,24,27)(H,26,28)/t14-,15- ARDSEKSLIINQMP-SHTZXODSSA-N 126417 US8778951, 227 Cyclin-T1 Homo sapiens 0.025907 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126417&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405627 225152776 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256333 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCCOC2)n1 InChI=1S/C21H29ClN6O/c22-18-10-26-20(27-16-5-3-15(23)4-6-16)8-17(18)19-11-24-12-21(28-19)25-9-14-2-1-7-29-13-14/h8,10-12,14-16H,1-7,9,13,23H2,(H,25,28)(H,26,27)/t14?,15-,16- JENCZQGBRRRHGE-KURUOMIPSA-N 126418 US8778951, 228 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126418&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937068 225152777 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256334 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCCOC2)n1 InChI=1S/C21H28ClN5O2/c22-18-10-25-20(26-15-3-5-16(28)6-4-15)8-17(18)19-11-23-12-21(27-19)24-9-14-2-1-7-29-13-14/h8,10-12,14-16,28H,1-7,9,13H2,(H,24,27)(H,25,26)/t14?,15-,16- UHBPTWDWEKLBAG-KURUOMIPSA-N 126419 US8778951, 229 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126419&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907430 225152778 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256335 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCS(=O)(=O)CC2)n1 InChI=1S/C22H30ClN5O2S/c23-19-14-26-22(27-17-6-4-16(24)5-7-17)12-18(19)20-2-1-3-21(28-20)25-13-15-8-10-31(29,30)11-9-15/h1-3,12,14-17H,4-11,13,24H2,(H,25,28)(H,26,27)/t16-,17- VNODXGCBBLSRKA-QAQDUYKDSA-N 126420 US8778951, 230 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126420&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127444 225152779 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256336 Cc1ncc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C22H31ClN6O/c1-14-22(27-11-15-6-8-30-9-7-15)29-20(13-25-14)18-10-21(26-12-19(18)23)28-17-4-2-16(24)3-5-17/h10,12-13,15-17H,2-9,11,24H2,1H3,(H,26,28)(H,27,29)/t16-,17- DBASVPRWFZOBPP-QAQDUYKDSA-N 126421 US8778951, 231 Cyclin-T1 Homo sapiens 0.014853 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126421&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937116 225152780 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256337 N[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1nc(NCC2CCOCC2)cnc1Cl InChI=1S/C21H29ClN6O/c22-21-20(28-19(13-26-21)25-12-14-6-9-29-10-7-14)15-5-8-24-18(11-15)27-17-3-1-16(23)2-4-17/h5,8,11,13-14,16-17H,1-4,6-7,9-10,12,23H2,(H,24,27)(H,25,28)/t16-,17- BQMJVUJVARCOJD-QAQDUYKDSA-N 126422 US8778951, 232 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126422&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907427 225152781 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256338 Cc1ncc(NCC2CCOCC2)nc1-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C22H31ClN6O/c1-14-22(29-21(13-25-14)26-11-15-6-8-30-9-7-15)18-10-20(27-12-19(18)23)28-17-4-2-16(24)3-5-17/h10,12-13,15-17H,2-9,11,24H2,1H3,(H,26,29)(H,27,28)/t16-,17- HUYVAQQNPXUJGE-QAQDUYKDSA-N 126423 US8778951, 233 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126423&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127086 225152782 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256339 NC[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H25ClFN5/c24-20-14-28-23(29-18-8-7-15(10-18)12-26)11-19(20)21-5-2-6-22(30-21)27-13-16-3-1-4-17(25)9-16/h1-6,9,11,14-15,18H,7-8,10,12-13,26H2,(H,27,30)(H,28,29)/t15-,18+/m0/s1 XUCIEBVLZSQITO-MAUKXSAKSA-N 126424 US8778951, 234 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126424&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405486 225152783 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256340 CNC[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H27ClFN5/c1-27-13-17-8-9-19(11-17)30-24-12-20(21(25)15-29-24)22-6-3-7-23(31-22)28-14-16-4-2-5-18(26)10-16/h2-7,10,12,15,17,19,27H,8-9,11,13-14H2,1H3,(H,28,31)(H,29,30)/t17-,19+/m0/s1 PUZSNAYWDZWNBI-PKOBYXMFSA-N 126425 US8778951, 235 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126425&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907863 225152784 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256341 CCNC[C@H]1CC[C@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5/c1-2-28-14-18-9-10-20(12-18)31-25-13-21(22(26)16-30-25)23-7-4-8-24(32-23)29-15-17-5-3-6-19(27)11-17/h3-8,11,13,16,18,20,28H,2,9-10,12,14-15H2,1H3,(H,29,32)(H,30,31)/t18-,20+/m0/s1 ULXWBFOXHYJLFM-AZUAARDMSA-N 126426 US8778951, 236 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126426&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405485 225152785 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256342 NC[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C23H25ClFN5/c24-20-14-28-23(29-18-8-7-15(10-18)12-26)11-19(20)21-5-2-6-22(30-21)27-13-16-3-1-4-17(25)9-16/h1-6,9,11,14-15,18H,7-8,10,12-13,26H2,(H,27,30)(H,28,29)/t15-,18+/m1/s1 XUCIEBVLZSQITO-QAPCUYQASA-N 126427 US8778951, 237 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126427&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405490 225152786 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256343 CNC[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H27ClFN5/c1-27-13-17-8-9-19(11-17)30-24-12-20(21(25)15-29-24)22-6-3-7-23(31-22)28-14-16-4-2-5-18(26)10-16/h2-7,10,12,15,17,19,27H,8-9,11,13-14H2,1H3,(H,28,31)(H,29,30)/t17-,19+/m1/s1 PUZSNAYWDZWNBI-MJGOQNOKSA-N 126428 US8778951, 238 Cyclin-T1 Homo sapiens 0.013635 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126428&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405347 225152787 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256344 CCNC[C@@H]1CC[C@@H](C1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C25H29ClFN5/c1-2-28-14-18-9-10-20(12-18)31-25-13-21(22(26)16-30-25)23-7-4-8-24(32-23)29-15-17-5-3-6-19(27)11-17/h3-8,11,13,16,18,20,28H,2,9-10,12,14-15H2,1H3,(H,29,32)(H,30,31)/t18-,20+/m1/s1 ULXWBFOXHYJLFM-QUCCMNQESA-N 126429 US8778951, 239 Cyclin-T1 Homo sapiens 0.01842 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126429&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405545 225152788 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256345 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(C2CC2)c(NCC2CCOCC2)n1 InChI=1S/C24H33ClN6O/c25-20-13-27-22(30-18-5-3-17(26)4-6-18)11-19(20)21-14-28-23(16-1-2-16)24(31-21)29-12-15-7-9-32-10-8-15/h11,13-18H,1-10,12,26H2,(H,27,30)(H,29,31)/t17-,18- FZQNTDUVROUDDV-IYARVYRRSA-N 126430 US8778951, 240 Cyclin-T1 Homo sapiens 0.020961 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126430&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405521 225152789 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256346 CCc1ncc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C23H33ClN6O/c1-2-20-23(28-12-15-7-9-31-10-8-15)30-21(14-26-20)18-11-22(27-13-19(18)24)29-17-5-3-16(25)4-6-17/h11,13-17H,2-10,12,25H2,1H3,(H,27,29)(H,28,30)/t16-,17- MTJQOIOCNIVMQU-QAQDUYKDSA-N 126431 US8778951, 241 Cyclin-T1 Homo sapiens 0.06179 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126431&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405477 225152790 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256347 OC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C22H30ClN5O2/c23-19-11-26-21(27-17-3-1-16(14-29)2-4-17)9-18(19)20-12-24-13-22(28-20)25-10-15-5-7-30-8-6-15/h9,11-13,15-17,29H,1-8,10,14H2,(H,25,28)(H,26,27)/t16-,17- RWMPWDQZGMCTCW-QAQDUYKDSA-N 126432 US8778951, 242 Cyclin-T1 Homo sapiens 0.015408 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126432&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793999 225152791 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256348 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C24H35ClN6O2/c1-32-11-8-27-18-2-4-19(5-3-18)30-23-12-20(21(25)14-29-23)22-15-26-16-24(31-22)28-13-17-6-9-33-10-7-17/h12,14-19,27H,2-11,13H2,1H3,(H,28,31)(H,29,30)/t18-,19- WJXOYTOKFAPRAE-WGSAOQKQSA-N 126433 US8778951, 243 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126433&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907225 225152792 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256349 CC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C23H31ClN6O2/c1-15(31)28-17-2-4-18(5-3-17)29-22-10-19(20(24)12-27-22)21-13-25-14-23(30-21)26-11-16-6-8-32-9-7-16/h10,12-14,16-18H,2-9,11H2,1H3,(H,26,30)(H,27,29)(H,28,31)/t17-,18- MXMSHFXTVMUVPM-IYARVYRRSA-N 126434 US8778951, 244 Cyclin-T1 Homo sapiens 0.078984 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126434&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936920 225152793 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256350 CS(=O)(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C22H31ClN6O3S/c1-33(30,31)29-17-4-2-16(3-5-17)27-21-10-18(19(23)12-26-21)20-13-24-14-22(28-20)25-11-15-6-8-32-9-7-15/h10,12-17,29H,2-9,11H2,1H3,(H,25,28)(H,26,27)/t16-,17- LNKNPYQHKCMOMT-QAQDUYKDSA-N 126435 US8778951, 245 Cyclin-T1 Homo sapiens 0.05337 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126435&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405149 225152794 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256351 NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C22H31ClN6O/c23-19-12-27-21(28-17-3-1-15(10-24)2-4-17)9-18(19)20-13-25-14-22(29-20)26-11-16-5-7-30-8-6-16/h9,12-17H,1-8,10-11,24H2,(H,26,29)(H,27,28)/t15-,17- LCPYNFOQLWIZBS-JCNLHEQBSA-N 126436 US8778951, 246 Cyclin-T1 Homo sapiens 0.01154 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126436&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794051 225152795 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256352 CC(=O)NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)n1 InChI=1S/C24H33ClN6O2/c1-16(32)27-11-17-2-4-19(5-3-17)30-23-10-20(21(25)13-29-23)22-14-26-15-24(31-22)28-12-18-6-8-33-9-7-18/h10,13-15,17-19H,2-9,11-12H2,1H3,(H,27,32)(H,28,31)(H,29,30)/t17-,19- KECDZJDBYUHEDP-UAPYVXQJSA-N 126437 US8778951, 247 Cyclin-T1 Homo sapiens 0.02018 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126437&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794000 225152796 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256353 CN(CC1CCOCC1)c1cncc(n1)-c1cc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C22H31ClN6O/c1-29(14-15-6-8-30-9-7-15)22-13-25-12-20(28-22)18-10-21(26-11-19(18)23)27-17-4-2-16(24)3-5-17/h10-13,15-17H,2-9,14,24H2,1H3,(H,26,27)/t16-,17- MUCDEADRFNKQSA-QAQDUYKDSA-N 126438 US8778951, 248 Cyclin-T1 Homo sapiens 0.01058 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126438&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907224 225152797 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256354 CN(CC1CCOCC1)c1cncc(n1)-c1cc(N[C@H]2CC[C@H](CN)CC2)ncc1Cl InChI=1S/C23H33ClN6O/c1-30(15-17-6-8-31-9-7-17)23-14-26-13-21(29-23)19-10-22(27-12-20(19)24)28-18-4-2-16(11-25)3-5-18/h10,12-14,16-18H,2-9,11,15,25H2,1H3,(H,27,28)/t16-,18- ULYRZLIASWIAQZ-SAABIXHNSA-N 126439 US8778951, 249 Cyclin-T1 Homo sapiens 0.0318 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126439&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937056 225152798 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256355 CN(CC1CCOCC1)c1cncc(n1)-c1cc(N[C@H]2CC[C@H](O)CC2)ncc1Cl InChI=1S/C22H30ClN5O2/c1-28(14-15-6-8-30-9-7-15)22-13-24-12-20(27-22)18-10-21(25-11-19(18)23)26-16-2-4-17(29)5-3-16/h10-13,15-17,29H,2-9,14H2,1H3,(H,25,26)/t16-,17- GEYAVIIWCZJZHF-QAQDUYKDSA-N 126440 US8778951, 250 Cyclin-T1 Homo sapiens 0.02839 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126440&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405079 225152799 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256356 CN(CC1CCOCC1)c1cncc(n1)-c1cc(N[C@H]2CC[C@H](CO)CC2)ncc1Cl InChI=1S/C23H32ClN5O2/c1-29(14-16-6-8-31-9-7-16)23-13-25-12-21(28-23)19-10-22(26-11-20(19)24)27-18-4-2-17(15-30)3-5-18/h10-13,16-18,30H,2-9,14-15H2,1H3,(H,26,27)/t17-,18- ZEFIOWZUNWKPRA-IYARVYRRSA-N 126441 US8778951, 251 Cyclin-T1 Homo sapiens 0.0432 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126441&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794026 225152800 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256357 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(n1)N(C)CC1CCOCC1 InChI=1S/C25H37ClN6O2/c1-32(17-18-7-10-34-11-8-18)25-16-27-15-23(31-25)21-13-24(29-14-22(21)26)30-20-5-3-19(4-6-20)28-9-12-33-2/h13-16,18-20,28H,3-12,17H2,1-2H3,(H,29,30)/t19-,20- RGKFLIJUPNFNSK-MXVIHJGJSA-N 126442 US8778951, 252 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126442&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405633 225152801 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256358 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C22H29Cl2N5O/c23-18-5-6-20(26-12-14-7-9-30-10-8-14)29-22(18)17-11-21(27-13-19(17)24)28-16-3-1-15(25)2-4-16/h5-6,11,13-16H,1-4,7-10,12,25H2,(H,26,29)(H,27,28)/t15-,16- XUBHXUBGGLOIAW-WKILWMFISA-N 126443 US8778951, 253 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126443&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908323 225152802 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256359 CS(=O)(=O)CCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C25H35Cl2N5O3S/c1-36(33,34)13-10-28-18-2-4-19(5-3-18)31-24-14-20(22(27)16-30-24)25-21(26)6-7-23(32-25)29-15-17-8-11-35-12-9-17/h6-7,14,16-19,28H,2-5,8-13,15H2,1H3,(H,29,32)(H,30,31)/t18-,19- WYCRRDCTTMDXLM-WGSAOQKQSA-N 126444 US8778951, 254 Cyclin-T1 Homo sapiens 0.00833 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126444&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936963 225152803 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256360 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)cnc1C(F)(F)F InChI=1S/C22H28ClF3N6O/c23-17-11-29-18(31-15-3-1-14(27)2-4-15)9-16(17)20-21(22(24,25)26)30-12-19(32-20)28-10-13-5-7-33-8-6-13/h9,11-15H,1-8,10,27H2,(H,28,32)(H,29,31)/t14-,15- UGYVYEPMPIGBEY-SHTZXODSSA-N 126445 US8778951, 255 Cyclin-T1 Homo sapiens 0.04232 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126445&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936971 225152804 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256361 CC1(C)C[C@H](CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)CCO1 InChI=1S/C24H34ClN5O/c1-24(2)13-16(10-11-31-24)14-27-22-5-3-4-21(30-22)19-12-23(28-15-20(19)25)29-18-8-6-17(26)7-9-18/h3-5,12,15-18H,6-11,13-14,26H2,1-2H3,(H,27,30)(H,28,29)/t16-,17-,18-/m1/s1 SIXWNROIJWKGBA-KZNAEPCWSA-N 126446 US8778951, 256 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126446&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906393 225152805 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256362 CC1(C)C[C@@H](CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)CCO1 InChI=1S/C24H34ClN5O/c1-24(2)13-16(10-11-31-24)14-27-22-5-3-4-21(30-22)19-12-23(28-15-20(19)25)29-18-8-6-17(26)7-9-18/h3-5,12,15-18H,6-11,13-14,26H2,1-2H3,(H,27,30)(H,28,29)/t16-,17-,18-/m0/s1 SIXWNROIJWKGBA-BZSNNMDCSA-N 126447 US8778951, 257 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126447&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906394 225152806 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256363 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C25H35Cl2N5O2/c1-33-13-10-28-18-2-4-19(5-3-18)31-24-14-20(22(27)16-30-24)25-21(26)6-7-23(32-25)29-15-17-8-11-34-12-9-17/h6-7,14,16-19,28H,2-5,8-13,15H2,1H3,(H,29,32)(H,30,31)/t18-,19- QZMKVJWZVCYODQ-WGSAOQKQSA-N 126448 US8778951, 258 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126448&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50905090 225152807 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256364 OCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C24H33Cl2N5O2/c25-20-5-6-22(28-14-16-7-11-33-12-8-16)31-24(20)19-13-23(29-15-21(19)26)30-18-3-1-17(2-4-18)27-9-10-32/h5-6,13,15-18,27,32H,1-4,7-12,14H2,(H,28,31)(H,29,30)/t17-,18- NMBNPSCYGIVNJY-IYARVYRRSA-N 126449 US8778951, 259 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126449&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907646 225152808 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256365 N[C@H]1CC[C@@H](CC1)Nc1cc(c(F)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C22H29ClFN5O/c23-18-5-6-20(26-12-14-7-9-30-10-8-14)29-22(18)17-11-21(27-13-19(17)24)28-16-3-1-15(25)2-4-16/h5-6,11,13-16H,1-4,7-10,12,25H2,(H,26,29)(H,27,28)/t15-,16- GOHIQSAHGXOXKE-WKILWMFISA-N 126450 US8778951, 260 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126450&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907862 225152809 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256366 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NC[C@H]2CCCOC2)n1 InChI=1S/C21H29ClN6O/c22-18-10-26-20(27-16-5-3-15(23)4-6-16)8-17(18)19-11-24-12-21(28-19)25-9-14-2-1-7-29-13-14/h8,10-12,14-16H,1-7,9,13,23H2,(H,25,28)(H,26,27)/t14-,15-,16-/m1/s1 JENCZQGBRRRHGE-BZUAXINKSA-N 126451 US8778951, 261 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126451&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50905091 225152810 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256367 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NC[C@@H]2CCCOC2)n1 InChI=1S/C21H29ClN6O/c22-18-10-26-20(27-16-5-3-15(23)4-6-16)8-17(18)19-11-24-12-21(28-19)25-9-14-2-1-7-29-13-14/h8,10-12,14-16H,1-7,9,13,23H2,(H,25,28)(H,26,27)/t14-,15-,16-/m0/s1 JENCZQGBRRRHGE-JYJNAYRXSA-N 126452 US8778951, 262 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126452&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907223 225152811 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256368 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NC[C@H]2CCCOC2)n1 InChI=1S/C21H28ClN5O2/c22-18-10-25-20(26-15-3-5-16(28)6-4-15)8-17(18)19-11-23-12-21(27-19)24-9-14-2-1-7-29-13-14/h8,10-12,14-16,28H,1-7,9,13H2,(H,24,27)(H,25,26)/t14-,15-,16-/m1/s1 UHBPTWDWEKLBAG-BZUAXINKSA-N 126453 US8778951, 263 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126453&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907221 225152812 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256369 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cncc(NC[C@@H]2CCCOC2)n1 InChI=1S/C21H28ClN5O2/c22-18-10-25-20(26-15-3-5-16(28)6-4-15)8-17(18)19-11-23-12-21(27-19)24-9-14-2-1-7-29-13-14/h8,10-12,14-16,28H,1-7,9,13H2,(H,24,27)(H,25,26)/t14-,15-,16-/m0/s1 UHBPTWDWEKLBAG-JYJNAYRXSA-N 126454 US8778951, 264 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126454&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907222 225152813 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256370 N[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C22H30ClN5O/c23-19-5-6-20(26-14-15-8-11-29-12-9-15)28-22(19)16-7-10-25-21(13-16)27-18-3-1-17(24)2-4-18/h5-7,10,13,15,17-18H,1-4,8-9,11-12,14,24H2,(H,25,27)(H,26,28)/t17-,18- OTNDDPAOXYYHJK-IYARVYRRSA-N 126455 US8778951, 265 Cyclin-T1 Homo sapiens 0.03258 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126455&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 60142669 225152814 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256371 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)c(Cl)cc1Cl InChI=1S/C22H28Cl3N5O/c23-17-10-18(24)22(28-11-13-5-7-31-8-6-13)30-21(17)16-9-20(27-12-19(16)25)29-15-3-1-14(26)2-4-15/h9-10,12-15H,1-8,11,26H2,(H,27,29)(H,28,30)/t14-,15- KORJSJHODXVHRX-SHTZXODSSA-N 126456 US8778951, 266 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126456&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906395 225152815 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256372 O[C@H]1CC[C@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C22H28Cl2N4O2/c23-18-5-6-20(25-12-14-7-9-30-10-8-14)28-22(18)17-11-21(26-13-19(17)24)27-15-1-3-16(29)4-2-15/h5-6,11,13-16,29H,1-4,7-10,12H2,(H,25,28)(H,26,27)/t15-,16+ OWGNQEONPZRJOL-IYBDPMFKSA-N 126457 US8778951, 267 Cyclin-T1 Homo sapiens 0.27007 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126457&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937044 225152816 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256373 Clc1ccc(NCC2CCCOC2)nc1-c1cc(N[C@H]2CC[C@@H](CC2)NC[C@H]2CCCO2)ncc1Cl InChI=1S/C27H37Cl2N5O2/c28-23-9-10-25(31-14-18-3-1-11-35-17-18)34-27(23)22-13-26(32-16-24(22)29)33-20-7-5-19(6-8-20)30-15-21-4-2-12-36-21/h9-10,13,16,18-21,30H,1-8,11-12,14-15,17H2,(H,31,34)(H,32,33)/t18?,19-,20-,21-/m1/s1 WXQNQXUNMIXHKN-RQZKWSAFSA-N 126458 US8778951, 268 Cyclin-T1 Homo sapiens 0.008143 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126458&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794004 225152817 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256374 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2CCOCC2)n1 InChI=1S/C22H29ClFN5O/c23-18-13-26-21(28-16-3-1-15(25)2-4-16)11-17(18)20-6-5-19(24)22(29-20)27-12-14-7-9-30-10-8-14/h5-6,11,13-16H,1-4,7-10,12,25H2,(H,26,28)(H,27,29)/t15-,16- UWMLWTLPYYYKBA-WKILWMFISA-N 126459 US8778951, 269 Cyclin-T1 Homo sapiens 0.007945 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126459&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906396 225152818 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256375 Clc1ccc(NCC2CCOCC2)nc1-c1cc(N[C@H]2CC[C@@H](CC2)NC[C@@H]2CCCO2)ncc1Cl InChI=1S/C27H37Cl2N5O2/c28-23-7-8-25(31-15-18-9-12-35-13-10-18)34-27(23)22-14-26(32-17-24(22)29)33-20-5-3-19(4-6-20)30-16-21-2-1-11-36-21/h7-8,14,17-21,30H,1-6,9-13,15-16H2,(H,31,34)(H,32,33)/t19-,20-,21-/m0/s1 ZNALGWWRRZYQPR-ACRUOGEOSA-N 126460 US8778951, 270 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126460&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50905093 225152819 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256376 Clc1cnc(N[C@H]2CC[C@@H](CC2)NCC2COCCO2)cc1-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C27H37Cl2N5O3/c28-23-5-6-25(31-14-18-7-9-35-10-8-18)34-27(23)22-13-26(32-16-24(22)29)33-20-3-1-19(2-4-20)30-15-21-17-36-11-12-37-21/h5-6,13,16,18-21,30H,1-4,7-12,14-15,17H2,(H,31,34)(H,32,33)/t19-,20-,21? IKETVGVYHBTPOS-YGQOYYDZSA-N 126461 US8778951, 271 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126461&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405350 225152820 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256377 COCCN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C26H37Cl2N5O2/c1-33(11-14-34-2)20-5-3-19(4-6-20)31-25-15-21(23(28)17-30-25)26-22(27)7-8-24(32-26)29-16-18-9-12-35-13-10-18/h7-8,15,17-20H,3-6,9-14,16H2,1-2H3,(H,29,32)(H,30,31)/t19-,20- ZFAIHHLOVUEOSL-MXVIHJGJSA-N 126462 US8778951, 272 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126462&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50905094 225152821 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256285 COc1cnc(N[C@H]2CC[C@H](N)CC2)cc1-c1cccc(NCc2cccc(F)c2)n1 InChI=1S/C24H28FN5O/c1-31-22-15-28-24(29-19-10-8-18(26)9-11-19)13-20(22)21-6-3-7-23(30-21)27-14-16-4-2-5-17(25)12-16/h2-7,12-13,15,18-19H,8-11,14,26H2,1H3,(H,27,30)(H,28,29)/t18-,19- QXGKJBPWIZWABK-WGSAOQKQSA-N 126370 US8778951, 180 Cyclin-T1 Homo sapiens 0.01213 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126370&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937200 225152729 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256378 Clc1ccc(NCC2CCOCC2)nc1-c1ccnc(N[C@H]2CC[C@@H](CC2)NC[C@H]2CCCO2)c1 InChI=1S/C27H38ClN5O2/c28-24-7-8-25(31-17-19-10-14-34-15-11-19)33-27(24)20-9-12-29-26(16-20)32-22-5-3-21(4-6-22)30-18-23-2-1-13-35-23/h7-9,12,16,19,21-23,30H,1-6,10-11,13-15,17-18H2,(H,29,32)(H,31,33)/t21-,22-,23-/m1/s1 SCLIORFOQOCKAR-DNVJHFABSA-N 126463 US8778951, 273 Cyclin-T1 Homo sapiens 0.02293 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126463&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66955178 225152822 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256379 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C25H36ClN5O2/c1-32-15-12-27-20-2-4-21(5-3-20)30-24-16-19(8-11-28-24)25-22(26)6-7-23(31-25)29-17-18-9-13-33-14-10-18/h6-8,11,16,18,20-21,27H,2-5,9-10,12-15,17H2,1H3,(H,28,30)(H,29,31)/t20-,21- MBGHWLGJPXGTNW-MEMLXQNLSA-N 126464 US8778951, 274 Cyclin-T1 Homo sapiens 0.03777 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126464&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405551 225152823 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256380 O[C@H]1CC[C@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C22H29ClN4O2/c23-19-14-25-22(26-16-4-6-17(28)7-5-16)12-18(19)20-2-1-3-21(27-20)24-13-15-8-10-29-11-9-15/h1-3,12,14-17,28H,4-11,13H2,(H,24,27)(H,25,26)/t16-,17+ OAIFWLDGIQRRMJ-CALCHBBNSA-N 126465 US8778951, 275 Cyclin-T1 Homo sapiens 0.1463 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126465&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793956 225152824 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256381 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C25H36ClN5O2/c1-32-14-11-27-19-5-7-20(8-6-19)30-25-15-21(22(26)17-29-25)23-3-2-4-24(31-23)28-16-18-9-12-33-13-10-18/h2-4,15,17-20,27H,5-14,16H2,1H3,(H,28,31)(H,29,30)/t19-,20- FCWZGWHOUXCXQV-MXVIHJGJSA-N 126466 US8778951, 276 Cyclin-T1 Homo sapiens 0.00893 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126466&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405358 225152825 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256382 Clc1cnc(N[C@H]2CC[C@@H](CC2)NC[C@H]2CCCO2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C27H38ClN5O2/c28-24-18-31-27(32-21-8-6-20(7-9-21)29-17-22-3-2-12-35-22)15-23(24)25-4-1-5-26(33-25)30-16-19-10-13-34-14-11-19/h1,4-5,15,18-22,29H,2-3,6-14,16-17H2,(H,30,33)(H,31,32)/t20-,21-,22-/m1/s1 HEPDPBCXNVLRCE-YPAWHYETSA-N 126467 US8778951, 277 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126467&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50905321 225152826 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256383 Clc1cnc(N[C@H]2CC[C@@H](CC2)NC[C@@H]2CCCO2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C27H38ClN5O2/c28-24-18-31-27(32-21-8-6-20(7-9-21)29-17-22-3-2-12-35-22)15-23(24)25-4-1-5-26(33-25)30-16-19-10-13-34-14-11-19/h1,4-5,15,18-22,29H,2-3,6-14,16-17H2,(H,30,33)(H,31,32)/t20-,21-,22-/m0/s1 HEPDPBCXNVLRCE-FKBYEOEOSA-N 126468 US8778951, 278 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126468&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906173 225152827 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256384 COCCN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C26H38ClN5O2/c1-32(12-15-33-2)21-8-6-20(7-9-21)30-26-16-22(23(27)18-29-26)24-4-3-5-25(31-24)28-17-19-10-13-34-14-11-19/h3-5,16,18-21H,6-15,17H2,1-2H3,(H,28,31)(H,29,30)/t20-,21- VRVUFZDYVKMACF-MEMLXQNLSA-N 126469 US8778951, 279 Cyclin-T1 Homo sapiens 0.0131 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126469&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405360 225152828 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256385 Clc1cnc(N[C@H]2CC[C@@H](CC2)NC2CCOC2)cc1-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C26H35Cl2N5O2/c27-22-5-6-24(29-14-17-7-10-34-11-8-17)33-26(22)21-13-25(30-15-23(21)28)32-19-3-1-18(2-4-19)31-20-9-12-35-16-20/h5-6,13,15,17-20,31H,1-4,7-12,14,16H2,(H,29,33)(H,30,32)/t18-,19-,20? SPOSQVLUWJOKSF-ORXZLVCASA-N 126470 US8778951, 280 Cyclin-T1 Homo sapiens 0.0161 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126470&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937041 225152829 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256386 Fc1ccc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@@H](CC2)NC2COC2)ncc1Cl InChI=1S/C25H33ClFN5O2/c26-21-13-28-24(31-18-3-1-17(2-4-18)30-19-14-34-15-19)11-20(21)23-6-5-22(27)25(32-23)29-12-16-7-9-33-10-8-16/h5-6,11,13,16-19,30H,1-4,7-10,12,14-15H2,(H,28,31)(H,29,32)/t17-,18- GSQIRKHHKQXWMD-IYARVYRRSA-N 126471 US8778951, 281 Cyclin-T1 Homo sapiens 0.06124 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126471&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405626 225152830 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256387 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1F InChI=1S/C22H29ClFN5O/c23-18-13-27-21(28-16-3-1-15(25)2-4-16)11-17(18)22-19(24)5-6-20(29-22)26-12-14-7-9-30-10-8-14/h5-6,11,13-16H,1-4,7-10,12,25H2,(H,26,29)(H,27,28)/t15-,16- WMGPYQGAIPUPEE-WKILWMFISA-N 126472 US8778951, 282 Cyclin-T1 Homo sapiens 0.00794 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126472&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906174 225152831 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256388 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1F InChI=1S/C25H35ClFN5O2/c1-33-13-10-28-18-2-4-19(5-3-18)31-24-14-20(21(26)16-30-24)25-22(27)6-7-23(32-25)29-15-17-8-11-34-12-9-17/h6-7,14,16-19,28H,2-5,8-13,15H2,1H3,(H,29,32)(H,30,31)/t18-,19- ZLSKXNHQZWAJJL-WGSAOQKQSA-N 126473 US8778951, 283 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126473&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906175 225152832 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256389 C[C@H]1CC(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)C[C@@H](C)O1 InChI=1S/C24H34ClN5O/c1-15-10-17(11-16(2)31-15)13-27-23-5-3-4-22(30-23)20-12-24(28-14-21(20)25)29-19-8-6-18(26)7-9-19/h3-5,12,14-19H,6-11,13,26H2,1-2H3,(H,27,30)(H,28,29)/t15-,16+,17?,18-,19- ZOZYLYIMEXJKIZ-JLXVPIGTSA-N 126474 US8778951, 284 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126474&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906824 225152833 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256390 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2C[C@H](C)O[C@H](C)C2)n1 InChI=1S/C27H40ClN5O2/c1-18-13-20(14-19(2)35-18)16-30-26-6-4-5-25(33-26)23-15-27(31-17-24(23)28)32-22-9-7-21(8-10-22)29-11-12-34-3/h4-6,15,17-22,29H,7-14,16H2,1-3H3,(H,30,33)(H,31,32)/t18-,19+,20?,21-,22- XTJBKCYRYSWLNN-FBDGTFNVSA-N 126475 US8778951, 285 Cyclin-T1 Homo sapiens 0.002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126475&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 58127373 225152834 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256391 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Br InChI=1S/C22H29BrClN5O/c23-18-5-6-20(26-12-14-7-9-30-10-8-14)29-22(18)17-11-21(27-13-19(17)24)28-16-3-1-15(25)2-4-16/h5-6,11,13-16H,1-4,7-10,12,25H2,(H,26,29)(H,27,28)/t15-,16- HOXLIBDYTOKHAY-WKILWMFISA-N 126476 US8778951, 286 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126476&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906176 225152835 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256392 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C26H38ClN5O2/c1-18(17-33-2)30-20-6-8-21(9-7-20)31-26-14-22(23(27)16-29-26)24-4-3-5-25(32-24)28-15-19-10-12-34-13-11-19/h3-5,14,16,18-21,30H,6-13,15,17H2,1-2H3,(H,28,32)(H,29,31)/t18-,20-,21-/m1/s1 SCQDBDNXLLRSGY-HMXCVIKNSA-N 126477 US8778951, 287 Cyclin-T1 Homo sapiens 0.003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126477&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937103 225152836 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256393 O[C@H](CN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1)C(F)(F)F InChI=1S/C25H33ClF3N5O2/c26-20-14-32-24(33-18-6-4-17(5-7-18)30-15-22(35)25(27,28)29)12-19(20)21-2-1-3-23(34-21)31-13-16-8-10-36-11-9-16/h1-3,12,14,16-18,22,30,35H,4-11,13,15H2,(H,31,34)(H,32,33)/t17-,18-,22-/m1/s1 ZKOMTUWFQKNBEF-JBYIUTFZSA-N 126478 US8778951, 288 Cyclin-T1 Homo sapiens 0.003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126478&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937144 225152837 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256394 O[C@@H](CN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1)C(F)(F)F InChI=1S/C25H33ClF3N5O2/c26-20-14-32-24(33-18-6-4-17(5-7-18)30-15-22(35)25(27,28)29)12-19(20)21-2-1-3-23(34-21)31-13-16-8-10-36-11-9-16/h1-3,12,14,16-18,22,30,35H,4-11,13,15H2,(H,31,34)(H,32,33)/t17-,18-,22-/m0/s1 ZKOMTUWFQKNBEF-SPEDKVCISA-N 126479 US8778951, 289 Cyclin-T1 Homo sapiens 0.004 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126479&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794028 225152838 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256395 O[C@@H](CN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl)C(F)(F)F InChI=1S/C25H32Cl2F3N5O2/c26-19-5-6-22(32-12-15-7-9-37-10-8-15)35-24(19)18-11-23(33-13-20(18)27)34-17-3-1-16(2-4-17)31-14-21(36)25(28,29)30/h5-6,11,13,15-17,21,31,36H,1-4,7-10,12,14H2,(H,32,35)(H,33,34)/t16-,17-,21-/m0/s1 FBOYNYMJVWJCDE-FIKGOQFSSA-N 126480 US8778951, 290 Cyclin-T1 Homo sapiens 0.002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126480&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907434 225152839 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256396 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C26H37Cl2N5O2/c1-17(16-34-2)31-19-3-5-20(6-4-19)32-25-13-21(23(28)15-30-25)26-22(27)7-8-24(33-26)29-14-18-9-11-35-12-10-18/h7-8,13,15,17-20,31H,3-6,9-12,14,16H2,1-2H3,(H,29,33)(H,30,32)/t17-,19-,20-/m1/s1 VEDRCFMMKBZLPD-MISYRCLQSA-N 126481 US8778951, 291 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126481&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908083 225152840 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256397 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Br InChI=1S/C25H35BrClN5O2/c1-33-13-10-28-18-2-4-19(5-3-18)31-24-14-20(22(27)16-30-24)25-21(26)6-7-23(32-25)29-15-17-8-11-34-12-9-17/h6-7,14,16-19,28H,2-5,8-13,15H2,1H3,(H,29,32)(H,30,31)/t18-,19- XKTVIDCZCLOYMW-WGSAOQKQSA-N 126482 US8778951, 292 Cyclin-T1 Homo sapiens 0.002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126482&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906177 225152841 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256398 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1F InChI=1S/C26H37ClFN5O2/c1-17(16-34-2)31-19-3-5-20(6-4-19)32-25-13-21(22(27)15-30-25)26-23(28)7-8-24(33-26)29-14-18-9-11-35-12-10-18/h7-8,13,15,17-20,31H,3-6,9-12,14,16H2,1-2H3,(H,29,33)(H,30,32)/t17-,19-,20-/m1/s1 URLDOKUCRNQHLA-MISYRCLQSA-N 126483 US8778951, 293 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126483&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908084 225152842 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256399 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2CCOCC2)n1 InChI=1S/C26H37ClFN5O2/c1-17(16-34-2)31-19-3-5-20(6-4-19)32-25-13-21(22(27)15-29-25)24-8-7-23(28)26(33-24)30-14-18-9-11-35-12-10-18/h7-8,13,15,17-20,31H,3-6,9-12,14,16H2,1-2H3,(H,29,32)(H,30,33)/t17-,19-,20-/m1/s1 CZGFGINSVBASOJ-MISYRCLQSA-N 126484 US8778951, 294 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126484&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908085 225152843 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256400 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C22H28Cl2N4O2/c23-18-5-6-20(25-12-14-7-9-30-10-8-14)28-22(18)17-11-21(26-13-19(17)24)27-15-1-3-16(29)4-2-15/h5-6,11,13-16,29H,1-4,7-10,12H2,(H,25,28)(H,26,27)/t15-,16- OWGNQEONPZRJOL-WKILWMFISA-N 126486 US8778951, 296 Cyclin-T1 Homo sapiens 0.277 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126486&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937044 225152844 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256401 CC1(C)CC(CNc2ccc(Cl)c(n2)-c2cc(N[C@H]3CC[C@H](O)CC3)ncc2Cl)CCO1 InChI=1S/C24H32Cl2N4O2/c1-24(2)12-15(9-10-32-24)13-27-21-8-7-19(25)23(30-21)18-11-22(28-14-20(18)26)29-16-3-5-17(31)6-4-16/h7-8,11,14-17,31H,3-6,9-10,12-13H2,1-2H3,(H,27,30)(H,28,29)/t15?,16-,17- FVWUIZMDTDYWLC-ATBAIXNZSA-N 126487 US8778951, 297 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126487&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907435 225152845 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256402 CC1(C)CC(CNc2ccc(Cl)c(n2)-c2cc(N[C@H]3CC[C@@H](CC3)NC[C@H](O)C(F)(F)F)ncc2Cl)CCO1 InChI=1S/C27H36Cl2F3N5O2/c1-26(2)12-16(9-10-39-26)13-34-23-8-7-20(28)25(37-23)19-11-24(35-14-21(19)29)36-18-5-3-17(4-6-18)33-15-22(38)27(30,31)32/h7-8,11,14,16-18,22,33,38H,3-6,9-10,12-13,15H2,1-2H3,(H,34,37)(H,35,36)/t16?,17-,18-,22-/m0/s1 SRSJFQBTHBNRIZ-KGFKZWSBSA-N 126488 US8778951, 298 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126488&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936929 225152846 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256403 CC1(C)CC(CNc2ccc(Cl)c(n2)-c2cc(N[C@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)ncc2Cl)CCO1 InChI=1S/C27H36Cl2F3N5O2/c1-26(2)12-16(9-10-39-26)13-34-23-8-7-20(28)25(37-23)19-11-24(35-14-21(19)29)36-18-5-3-17(4-6-18)33-15-22(38)27(30,31)32/h7-8,11,14,16-18,22,33,38H,3-6,9-10,12-13,15H2,1-2H3,(H,34,37)(H,35,36)/t16?,17-,18-,22-/m1/s1 SRSJFQBTHBNRIZ-PKFPGOFKSA-N 126489 US8778951, 299 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126489&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937185 225152847 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256404 Clc1cnc(NC[C@@H]2CCCNC2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C22H30ClN5O/c23-19-15-27-22(26-14-17-3-2-8-24-12-17)11-18(19)20-4-1-5-21(28-20)25-13-16-6-9-29-10-7-16/h1,4-5,11,15-17,24H,2-3,6-10,12-14H2,(H,25,28)(H,26,27)/t17-/m1/s1 IZXFJQNCWNLQEB-QGZVFWFLSA-N 126490 US8778951, 300 Cyclin-T1 Homo sapiens 0.219 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126490&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405499 225152848 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256405 FC(F)(F)OCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C25H33ClF3N5O2/c26-21-16-32-24(33-19-6-4-18(5-7-19)30-10-13-36-25(27,28)29)14-20(21)22-2-1-3-23(34-22)31-15-17-8-11-35-12-9-17/h1-3,14,16-19,30H,4-13,15H2,(H,31,34)(H,32,33)/t18-,19- URFGLZOAZQPNRA-WGSAOQKQSA-N 126491 US8778951, 301 Cyclin-T1 Homo sapiens 0.003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126491&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937205 225152849 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256406 FC(F)(F)OCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C25H32Cl2F3N5O2/c26-20-5-6-22(32-14-16-7-10-36-11-8-16)35-24(20)19-13-23(33-15-21(19)27)34-18-3-1-17(2-4-18)31-9-12-37-25(28,29)30/h5-6,13,15-18,31H,1-4,7-12,14H2,(H,32,35)(H,33,34)/t17-,18- ZEHPZKYINPGMCT-IYARVYRRSA-N 126492 US8778951, 302 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126492&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906392 225152850 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256407 Clc1cnc(NC[C@H]2CCCN2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C21H28ClN5O/c22-18-14-26-21(25-13-16-3-2-8-23-16)11-17(18)19-4-1-5-20(27-19)24-12-15-6-9-28-10-7-15/h1,4-5,11,14-16,23H,2-3,6-10,12-13H2,(H,24,27)(H,25,26)/t16-/m1/s1 YGZJTPRFLHVRDC-MRXNPFEDSA-N 126493 US8778951, 303 Cyclin-T1 Homo sapiens 1.296 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126493&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405356 225152851 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256408 Clc1cnc(NC[C@@H]2CCCN2)cc1-c1cccc(NCC2CCOCC2)n1 InChI=1S/C21H28ClN5O/c22-18-14-26-21(25-13-16-3-2-8-23-16)11-17(18)19-4-1-5-20(27-19)24-12-15-6-9-28-10-7-15/h1,4-5,11,14-16,23H,2-3,6-10,12-13H2,(H,24,27)(H,25,26)/t16-/m0/s1 YGZJTPRFLHVRDC-INIZCTEOSA-N 126494 US8778951, 304 Cyclin-T1 Homo sapiens 6.188 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126494&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405357 225152852 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256409 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)OC)n1 InChI=1S/C27H40ClN5O3/c1-19(17-34-2)31-20-7-9-21(10-8-20)32-26-15-22(23(28)16-29-26)24-5-4-6-25(33-24)30-18-27(35-3)11-13-36-14-12-27/h4-6,15-16,19-21,31H,7-14,17-18H2,1-3H3,(H,29,32)(H,30,33)/t19-,20-,21-/m1/s1 XOSGENZFYFKLCS-NJDAHSKKSA-N 126495 US8778951, 305 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126495&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405361 225152853 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256410 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCCCC2)OC)n1 InChI=1S/C28H42ClN5O2/c1-20(18-35-2)32-21-10-12-22(13-11-21)33-27-16-23(24(29)17-30-27)25-8-7-9-26(34-25)31-19-28(36-3)14-5-4-6-15-28/h7-9,16-17,20-22,32H,4-6,10-15,18-19H2,1-3H3,(H,30,33)(H,31,34)/t20-,21-,22-/m1/s1 GIAUVCPFQNIWCX-YPAWHYETSA-N 126496 US8778951, 306 Cyclin-T1 Homo sapiens 0.009 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126496&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405362 225152854 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256411 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2COC(C)(C)CO2)n1 InChI=1S/C27H40ClN5O3/c1-18(15-34-4)31-19-8-10-20(11-9-19)32-26-12-22(23(28)14-30-26)24-6-5-7-25(33-24)29-13-21-16-36-27(2,3)17-35-21/h5-7,12,14,18-21,31H,8-11,13,15-17H2,1-4H3,(H,29,33)(H,30,32)/t18-,19-,20-,21?/m1/s1 GOZUEPJIAXGJND-YJUWBKPTSA-N 126497 US8778951, 307 Cyclin-T1 Homo sapiens 0.008 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126497&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937064 225152855 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256412 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(c(NCC2CCOCC2)n1)C(F)(F)F InChI=1S/C27H37ClF3N5O2/c1-17(16-37-2)34-19-3-5-20(6-4-19)35-25-13-21(23(28)15-32-25)24-8-7-22(27(29,30)31)26(36-24)33-14-18-9-11-38-12-10-18/h7-8,13,15,17-20,34H,3-6,9-12,14,16H2,1-2H3,(H,32,35)(H,33,36)/t17-,19-,20-/m1/s1 RJJLVZRLULXDOR-MISYRCLQSA-N 126498 US8778951, 308 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126498&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793957 225152856 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256413 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1C(F)(F)F InChI=1S/C27H37ClF3N5O2/c1-17(16-37-2)34-19-3-5-20(6-4-19)35-25-13-21(23(28)15-33-25)26-22(27(29,30)31)7-8-24(36-26)32-14-18-9-11-38-12-10-18/h7-8,13,15,17-20,34H,3-6,9-12,14,16H2,1-2H3,(H,32,36)(H,33,35)/t17-,19-,20-/m1/s1 WWTWYISYTASUMK-MISYRCLQSA-N 126499 US8778951, 309 Cyclin-T1 Homo sapiens 0.035 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126499&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405506 225152857 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256414 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1 XWQVQSXLXAXOPJ-NJDAHSKKSA-N 126500 US11591322, Compound NVP-2::US8778951, 310 Cyclin-T1 Homo sapiens 0.0003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126500&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937006 225152858 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256415 CC1(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)CCOCC1 InChI=1S/C23H32ClN5O/c1-23(9-11-30-12-10-23)15-27-21-4-2-3-20(29-21)18-13-22(26-14-19(18)24)28-17-7-5-16(25)6-8-17/h2-4,13-14,16-17H,5-12,15,25H2,1H3,(H,26,28)(H,27,29)/t16-,17- CDOPCSZZBPSJEB-QAQDUYKDSA-N 126501 US8778951, 311 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126501&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906397 225152859 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256416 CC1(CNc2nc(ccc2F)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)CCOCC1 InChI=1S/C23H31ClFN5O/c1-23(8-10-31-11-9-23)14-28-22-19(25)6-7-20(30-22)17-12-21(27-13-18(17)24)29-16-4-2-15(26)3-5-16/h6-7,12-13,15-16H,2-5,8-11,14,26H2,1H3,(H,27,29)(H,28,30)/t15-,16- RPQNTZHFUREGDI-WKILWMFISA-N 126502 US8778951, 312 Cyclin-T1 Homo sapiens 0.0003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126502&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906612 225152860 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256417 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(F)CCOCC2)n1 InChI=1S/C22H29ClFN5O/c23-18-13-26-21(28-16-6-4-15(25)5-7-16)12-17(18)19-2-1-3-20(29-19)27-14-22(24)8-10-30-11-9-22/h1-3,12-13,15-16H,4-11,14,25H2,(H,26,28)(H,27,29)/t15-,16- RHYTUGYKLVRVAV-WKILWMFISA-N 126503 US8778951, 313 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126503&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50906613 225152861 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256418 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2CCOCC2)n1 InChI=1S/C25H35ClFN5O2/c1-33-13-10-28-18-2-4-19(5-3-18)31-24-14-20(21(26)16-29-24)23-7-6-22(27)25(32-23)30-15-17-8-11-34-12-9-17/h6-7,14,16-19,28H,2-5,8-13,15H2,1H3,(H,29,31)(H,30,32)/t18-,19- IQQSAJSBQYLYIH-WGSAOQKQSA-N 126504 US8778951, 314 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126504&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908320 225152862 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256419 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1nccc(c1F)-c1nc(NCC2CCOC(C)(C)C2)ccc1C(F)(F)F InChI=1S/C29H41F4N5O2/c1-18(17-39-4)36-20-5-7-21(8-6-20)37-27-25(30)22(11-13-34-27)26-23(29(31,32)33)9-10-24(38-26)35-16-19-12-14-40-28(2,3)15-19/h9-11,13,18-21,36H,5-8,12,14-17H2,1-4H3,(H,34,37)(H,35,38)/t18-,19?,20-,21-/m1/s1 OBTUOUPVYSRFKF-BFRJHAQASA-N 126505 US8778951, 315 Cyclin-T1 Homo sapiens 0.018 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126505&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 86766526 225152863 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256420 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2COCC(C)(C)O2)n1 InChI=1S/C27H40ClN5O3/c1-18(15-34-4)31-19-8-10-20(11-9-19)32-26-12-22(23(28)14-30-26)24-6-5-7-25(33-24)29-13-21-16-35-17-27(2,3)36-21/h5-7,12,14,18-21,31H,8-11,13,15-17H2,1-4H3,(H,29,33)(H,30,32)/t18-,19-,20-,21?/m1/s1 VYOWNUQJYQBUFB-YJUWBKPTSA-N 126506 US8778951, 316 Cyclin-T1 Homo sapiens 0.009 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126506&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937240 225152864 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256421 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)c(F)cc1F InChI=1S/C22H28ClF2N5O/c23-17-12-27-20(29-15-3-1-14(26)2-4-15)9-16(17)21-18(24)10-19(25)22(30-21)28-11-13-5-7-31-8-6-13/h9-10,12-15H,1-8,11,26H2,(H,27,29)(H,28,30)/t14-,15- XZZAVRWLEDOHCH-SHTZXODSSA-N 126507 US8778951, 318 Cyclin-T1 Homo sapiens 0.00026 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126507&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907428 225152865 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256422 CC(CS(C)(=O)=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2CCOCC2)n1 InChI=1S/C26H37ClFN5O3S/c1-17(16-37(2,34)35)31-19-3-5-20(6-4-19)32-25-13-21(22(27)15-29-25)24-8-7-23(28)26(33-24)30-14-18-9-11-36-12-10-18/h7-8,13,15,17-20,31H,3-6,9-12,14,16H2,1-2H3,(H,29,32)(H,30,33)/t17?,19-,20- MRGGLKQNFSUODM-DASMUKNDSA-N 126508 US8778951, 319 Cyclin-T1 Homo sapiens 0.004 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126508&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794057 225152866 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256423 CC1(C)OC[C@@H](CN[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2nc(NCC3CCOCC3)ccc2Cl)O1 InChI=1S/C28H39Cl2N5O3/c1-28(2)37-17-21(38-28)15-31-19-3-5-20(6-4-19)34-26-13-22(24(30)16-33-26)27-23(29)7-8-25(35-27)32-14-18-9-11-36-12-10-18/h7-8,13,16,18-21,31H,3-6,9-12,14-15,17H2,1-2H3,(H,32,35)(H,33,34)/t19-,20-,21-/m1/s1 RXMZVILRJZNWNL-NJDAHSKKSA-N 126509 US8778951, 320 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126509&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907641 225152867 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256424 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NC[C@H]2CCCCO2)ccc1Cl InChI=1S/C26H37Cl2N5O2/c1-17(16-34-2)31-18-6-8-19(9-7-18)32-25-13-21(23(28)15-30-25)26-22(27)10-11-24(33-26)29-14-20-5-3-4-12-35-20/h10-11,13,15,17-20,31H,3-9,12,14,16H2,1-2H3,(H,29,33)(H,30,32)/t17-,18-,19-,20-/m1/s1 WQUXMLFYOIBSFZ-UAFMIMERSA-N 126510 US8778951, 321 Cyclin-T1 Homo sapiens 0.011 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126510&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937102 225152868 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256425 Fc1ccc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@@H](CC2)NC2CCS(=O)(=O)C2)ncc1Cl InChI=1S/C26H35ClFN5O3S/c27-22-15-29-25(32-19-3-1-18(2-4-19)31-20-9-12-37(34,35)16-20)13-21(22)24-6-5-23(28)26(33-24)30-14-17-7-10-36-11-8-17/h5-6,13,15,17-20,31H,1-4,7-12,14,16H2,(H,29,32)(H,30,33)/t18-,19-,20? WPGOWNITNUCOEV-ORXZLVCASA-N 126511 US8778951, 322 Cyclin-T1 Homo sapiens 0.003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126511&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405628 225152869 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256426 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NC[C@@H]2CCCOC2)ccc1Cl InChI=1S/C26H37Cl2N5O2/c1-17(15-34-2)31-19-5-7-20(8-6-19)32-25-12-21(23(28)14-30-25)26-22(27)9-10-24(33-26)29-13-18-4-3-11-35-16-18/h9-10,12,14,17-20,31H,3-8,11,13,15-16H2,1-2H3,(H,29,33)(H,30,32)/t17-,18+,19-,20-/m1/s1 SQFDOWFJUZXLIH-IYWMVGAKSA-N 126512 US8778951, 323 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126512&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907858 225152870 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256427 Fc1ccc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@@H](CC2)NCC2CCO2)ncc1Cl InChI=1S/C26H35ClFN5O2/c27-22-16-30-25(32-19-3-1-18(2-4-19)29-15-20-9-12-35-20)13-21(22)24-6-5-23(28)26(33-24)31-14-17-7-10-34-11-8-17/h5-6,13,16-20,29H,1-4,7-12,14-15H2,(H,30,32)(H,31,33)/t18-,19-,20? MMZDKCYPVDPHLE-ORXZLVCASA-N 126513 US8778951, 324 Cyclin-T1 Homo sapiens 0.002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126513&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907645 225152871 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256428 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NC[C@@H]2CCCCO2)ccc1Cl InChI=1S/C26H37Cl2N5O2/c1-17(16-34-2)31-18-6-8-19(9-7-18)32-25-13-21(23(28)15-30-25)26-22(27)10-11-24(33-26)29-14-20-5-3-4-12-35-20/h10-11,13,15,17-20,31H,3-9,12,14,16H2,1-2H3,(H,29,33)(H,30,32)/t17-,18-,19-,20+/m1/s1 WQUXMLFYOIBSFZ-WTGUMLROSA-N 126514 US8778951, 325 Cyclin-T1 Homo sapiens 0.01 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126514&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937042 225152872 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256429 CS(=O)(=O)CCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2CCOCC2)n1 InChI=1S/C25H35ClFN5O3S/c1-36(33,34)13-10-28-18-2-4-19(5-3-18)31-24-14-20(21(26)16-29-24)23-7-6-22(27)25(32-23)30-15-17-8-11-35-12-9-17/h6-7,14,16-19,28H,2-5,8-13,15H2,1H3,(H,29,31)(H,30,32)/t18-,19- SAHSRLUXNDQZSH-WGSAOQKQSA-N 126515 US8778951, 326 Cyclin-T1 Homo sapiens 0.00049 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126515&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907643 225152873 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256430 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NC[C@H]2CCCOC2)ccc1Cl InChI=1S/C26H37Cl2N5O2/c1-17(15-34-2)31-19-5-7-20(8-6-19)32-25-12-21(23(28)14-30-25)26-22(27)9-10-24(33-26)29-13-18-4-3-11-35-16-18/h9-10,12,14,17-20,31H,3-8,11,13,15-16H2,1-2H3,(H,29,33)(H,30,32)/t17-,18-,19-,20-/m1/s1 SQFDOWFJUZXLIH-UAFMIMERSA-N 126516 US8778951, 327 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126516&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907644 225152874 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256431 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@H]2CCOC(C)(C)C2)n1 InChI=1S/C28H42ClN5O2/c1-19(18-35-4)32-21-8-10-22(11-9-21)33-27-14-23(24(29)17-31-27)25-6-5-7-26(34-25)30-16-20-12-13-36-28(2,3)15-20/h5-7,14,17,19-22,32H,8-13,15-16,18H2,1-4H3,(H,30,34)(H,31,33)/t19-,20+,21-,22-/m1/s1 NROKDTDCYXNXSQ-CIAFKFPVSA-N 126517 US8778951, 328 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126517&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908087 225152875 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256432 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2CCOC(C)(C)C2)n1 InChI=1S/C28H42ClN5O2/c1-19(18-35-4)32-21-8-10-22(11-9-21)33-27-14-23(24(29)17-31-27)25-6-5-7-26(34-25)30-16-20-12-13-36-28(2,3)15-20/h5-7,14,17,19-22,32H,8-13,15-16,18H2,1-4H3,(H,30,34)(H,31,33)/t19-,20?,21-,22-/m1/s1 NROKDTDCYXNXSQ-VTKXFCLISA-N 126518 US8778951, 329 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126518&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908086 225152876 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256433 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@@H]2CCOC(C)(C)C2)n1 InChI=1S/C28H42ClN5O2/c1-19(18-35-4)32-21-8-10-22(11-9-21)33-27-14-23(24(29)17-31-27)25-6-5-7-26(34-25)30-16-20-12-13-36-28(2,3)15-20/h5-7,14,17,19-22,32H,8-13,15-16,18H2,1-4H3,(H,30,34)(H,31,33)/t19-,20-,21-,22-/m1/s1 NROKDTDCYXNXSQ-GXRSIYKFSA-N 126519 US8778951, 330 Cyclin-T1 Homo sapiens 0.002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126519&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794029 225152877 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256434 Fc1ccc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@@H](CC2)NCC2CCS(=O)(=O)CC2)ncc1Cl InChI=1S/C28H39ClFN5O3S/c29-24-18-32-27(34-22-3-1-21(2-4-22)31-16-20-9-13-39(36,37)14-10-20)15-23(24)26-6-5-25(30)28(35-26)33-17-19-7-11-38-12-8-19/h5-6,15,18-22,31H,1-4,7-14,16-17H2,(H,32,34)(H,33,35)/t21-,22- IYLFDVWPVFARIE-HZCBDIJESA-N 126520 US8778951, 331 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126520&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50908319 225152878 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256435 CC1(CNc2nc(ccc2F)-c2cc(N[C@H]3CC[C@@H](CC3)NC3CCS(=O)(=O)C3)ncc2Cl)CCOCC1 InChI=1S/C27H37ClFN5O3S/c1-27(9-11-37-12-10-27)17-31-26-23(29)6-7-24(34-26)21-14-25(30-15-22(21)28)33-19-4-2-18(3-5-19)32-20-8-13-38(35,36)16-20/h6-7,14-15,18-20,32H,2-5,8-13,16-17H2,1H3,(H,30,33)(H,31,34)/t18-,19-,20? ZYLWCTYVGAXGGM-ORXZLVCASA-N 126521 US8778951, 332 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126521&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 50907027 225152879 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256436 CC1(N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2ccc(F)c(NCC3CCOCC3)n2)OCCO1 InChI=1S/C26H35ClFN5O3/c1-26(35-12-13-36-26)33-19-4-2-18(3-5-19)31-24-14-20(21(27)16-29-24)23-7-6-22(28)25(32-23)30-15-17-8-10-34-11-9-17/h6-7,14,16-19,33H,2-5,8-13,15H2,1H3,(H,29,31)(H,30,32)/t18-,19- OXUFEMLIJRZCRP-WGSAOQKQSA-N 126522 US8778951, 333 Cyclin-T1 Homo sapiens 0.004 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126522&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 86766527 225152880 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256437 CC1(N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2ccc(F)c(NCC3(C)CCOCC3)n2)OCCO1 InChI=1S/C27H37ClFN5O3/c1-26(9-11-35-12-10-26)17-31-25-22(29)7-8-23(33-25)20-15-24(30-16-21(20)28)32-18-3-5-19(6-4-18)34-27(2)36-13-14-37-27/h7-8,15-16,18-19,34H,3-6,9-14,17H2,1-2H3,(H,30,32)(H,31,33)/t18-,19- VAWGLAQKVMITLE-WGSAOQKQSA-N 126523 US8778951, 334 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126523&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 86766528 225152881 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256438 CC1(N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2ccc(F)c(NCC3(CCOCC3)C#N)n2)OCCO1 InChI=1S/C27H34ClFN6O3/c1-26(37-12-13-38-26)35-19-4-2-18(3-5-19)33-24-14-20(21(28)15-31-24)23-7-6-22(29)25(34-23)32-17-27(16-30)8-10-36-11-9-27/h6-7,14-15,18-19,35H,2-5,8-13,17H2,1H3,(H,31,33)(H,32,34)/t18-,19- XQXXPFWNQPCFCJ-WGSAOQKQSA-N 126524 US8778951, 335 Cyclin-T1 Homo sapiens 0.00027 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126524&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 86766529 225152882 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256439 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 InChI=1S/C26H34ClFN6O2/c1-35-13-10-30-18-2-4-19(5-3-18)33-24-14-20(21(27)15-31-24)23-7-6-22(28)25(34-23)32-17-26(16-29)8-11-36-12-9-26/h6-7,14-15,18-19,30H,2-5,8-13,17H2,1H3,(H,31,33)(H,32,34)/t18-,19- IWJDOAOJIGWZIC-WGSAOQKQSA-N 126528 US8778951, 339 Cyclin-T1 Homo sapiens 0.00017 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126528&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937159 225152883 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256440 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H36ClFN6O2/c1-18(15-36-2)33-19-3-5-20(6-4-19)34-25-13-21(22(28)14-31-25)24-8-7-23(29)26(35-24)32-17-27(16-30)9-11-37-12-10-27/h7-8,13-14,18-20,33H,3-6,9-12,15,17H2,1-2H3,(H,31,34)(H,32,35)/t18-,19-,20-/m1/s1 FKVVKQVKDBCJMQ-VAMGGRTRSA-N 126529 US8778951, 340 Cyclin-T1 Homo sapiens 0.00023 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126529&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936978 225152884 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256441 N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 InChI=1S/C23H28ClFN6O/c24-18-12-28-21(30-16-3-1-15(27)2-4-16)11-17(18)20-6-5-19(25)22(31-20)29-14-23(13-26)7-9-32-10-8-23/h5-6,11-12,15-16H,1-4,7-10,14,27H2,(H,28,30)(H,29,31)/t15-,16- AUNDMBQUJUNXOG-WKILWMFISA-N 126530 US8778951, 341 Cyclin-T1 Homo sapiens 0.00015 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126530&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937150 225152885 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256442 CCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 InChI=1S/C26H34ClFN6O/c1-2-11-30-18-3-5-19(6-4-18)33-24-14-20(21(27)15-31-24)23-8-7-22(28)25(34-23)32-17-26(16-29)9-12-35-13-10-26/h7-8,14-15,18-19,30H,2-6,9-13,17H2,1H3,(H,31,33)(H,32,34)/t18-,19- DXWKCBDYFCIUGT-WGSAOQKQSA-N 126531 US8778951, 342 Cyclin-T1 Homo sapiens 0.00017 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126531&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937119 225152886 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256443 CCCN(CCC)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H40ClFN6O/c1-3-13-37(14-4-2)22-7-5-21(6-8-22)35-27-17-23(24(30)18-33-27)26-10-9-25(31)28(36-26)34-20-29(19-32)11-15-38-16-12-29/h9-10,17-18,21-22H,3-8,11-16,20H2,1-2H3,(H,33,35)(H,34,36)/t21-,22- NMVUPOKILATOID-HZCBDIJESA-N 126532 US8778951, 343 Cyclin-T1 Homo sapiens 0.00031 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126532&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937135 225152887 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256444 CC1(CNc2nc(ccc2F)-c2cc(N[C@H]3CC[C@@H](CC3)NC3CCS(=O)(=O)CC3)ncc2Cl)CCOCC1 InChI=1S/C28H39ClFN5O3S/c1-28(10-12-38-13-11-28)18-32-27-24(30)6-7-25(35-27)22-16-26(31-17-23(22)29)34-20-4-2-19(3-5-20)33-21-8-14-39(36,37)15-9-21/h6-7,16-17,19-21,33H,2-5,8-15,18H2,1H3,(H,31,34)(H,32,35)/t19-,20- FFHHBMZPTFDRDJ-MXVIHJGJSA-N 126535 US8778951, 346 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126535&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70793959 225152888 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256445 CC1(CNc2nc(ccc2F)-c2cc(NC3CCC(CC3)NC3CS(=O)(=O)C3)ncc2Cl)CCOCC1 InChI=1S/C26H35ClFN5O3S/c1-26(8-10-36-11-9-26)16-30-25-22(28)6-7-23(33-25)20-12-24(29-13-21(20)27)32-18-4-2-17(3-5-18)31-19-14-37(34,35)15-19/h6-7,12-13,17-19,31H,2-5,8-11,14-16H2,1H3,(H,29,32)(H,30,33) KPTVNAYFQMTYFR-UHFFFAOYSA-N 126536 US8778951, 347 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126536&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794032 225152889 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256446 Clc1ccc(NCC2CCOCC2)nc1-c1cc(NC2CCC(CC2)NC2CCS(=O)(=O)CC2)ncc1Cl InChI=1S/C27H37Cl2N5O3S/c28-23-5-6-25(30-16-18-7-11-37-12-8-18)34-27(23)22-15-26(31-17-24(22)29)33-20-3-1-19(2-4-20)32-21-9-13-38(35,36)14-10-21/h5-6,15,17-21,32H,1-4,7-14,16H2,(H,30,34)(H,31,33) AIMSOUZQALDLOA-UHFFFAOYSA-N 126537 US8778951, 348 Cyclin-T1 Homo sapiens 0.002 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126537&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937009 225152890 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256447 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CO)CCOCC2)n1 InChI=1S/C27H40ClN5O3/c1-19(16-35-2)31-20-6-8-21(9-7-20)32-26-14-22(23(28)15-29-26)24-4-3-5-25(33-24)30-17-27(18-34)10-12-36-13-11-27/h3-5,14-15,19-21,31,34H,6-13,16-18H2,1-2H3,(H,29,32)(H,30,33)/t19-,20-,21-/m1/s1 UXVZTNFUCDUKSB-NJDAHSKKSA-N 126538 US8778951, 349 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126538&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937048 225152891 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256448 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CO)CCOCC2)n1 InChI=1S/C26H38ClN5O3/c1-34-14-11-28-19-5-7-20(8-6-19)31-25-15-21(22(27)16-29-25)23-3-2-4-24(32-23)30-17-26(18-33)9-12-35-13-10-26/h2-4,15-16,19-20,28,33H,5-14,17-18H2,1H3,(H,29,31)(H,30,32)/t19-,20- UVWSWBYJPMXGEG-MXVIHJGJSA-N 126539 US8778951, 350 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126539&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 68405516 225152892 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256449 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 InChI=1S/C23H27ClFN5O2/c24-18-12-27-21(29-15-1-3-16(31)4-2-15)11-17(18)20-6-5-19(25)22(30-20)28-14-23(13-26)7-9-32-10-8-23/h5-6,11-12,15-16,31H,1-4,7-10,14H2,(H,27,29)(H,28,30)/t15-,16- BTTVMKDPXLZLII-WKILWMFISA-N 126546 US8778951, 357 Cyclin-T1 Homo sapiens 0.00016 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126546&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937005 225152893 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256450 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1 XWQVQSXLXAXOPJ-NJDAHSKKSA-N 126547 US8778951, 358 Cyclin-T1 Homo sapiens 0.00017 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126547&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937006 225152894 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256451 O[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C23H28ClN5O2/c24-19-13-26-22(28-16-4-6-17(30)7-5-16)12-18(19)20-2-1-3-21(29-20)27-15-23(14-25)8-10-31-11-9-23/h1-3,12-13,16-17,30H,4-11,15H2,(H,26,28)(H,27,29)/t16-,17- QIBIYLXCABNMFT-QAQDUYKDSA-N 126548 US8778951, 359 Cyclin-T1 Homo sapiens 0.00024 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126548&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936832 225152895 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256452 CCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C25H33ClN6O/c1-2-28-18-6-8-19(9-7-18)31-24-14-20(21(26)15-29-24)22-4-3-5-23(32-22)30-17-25(16-27)10-12-33-13-11-25/h3-5,14-15,18-19,28H,2,6-13,17H2,1H3,(H,29,31)(H,30,32)/t18-,19- AKLQTILQYJZJRC-WGSAOQKQSA-N 126549 US8778951, 360 Cyclin-T1 Homo sapiens 0.00028 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126549&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936956 225152896 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256453 CN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C25H33ClN6O/c1-32(2)19-8-6-18(7-9-19)30-24-14-20(21(26)15-28-24)22-4-3-5-23(31-22)29-17-25(16-27)10-12-33-13-11-25/h3-5,14-15,18-19H,6-13,17H2,1-2H3,(H,28,30)(H,29,31)/t18-,19- IKTJCKZXQBIYHS-WGSAOQKQSA-N 126550 US8778951, 361 Cyclin-T1 Homo sapiens 0.0003 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126550&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937076 225152897 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256454 FC(F)(F)OCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C26H32ClF3N6O2/c27-21-15-33-24(35-19-6-4-18(5-7-19)32-10-13-38-26(28,29)30)14-20(21)22-2-1-3-23(36-22)34-17-25(16-31)8-11-37-12-9-25/h1-3,14-15,18-19,32H,4-13,17H2,(H,33,35)(H,34,36)/t18-,19- QIMDCYIJYDPKDO-WGSAOQKQSA-N 126551 US8778951, 362 Cyclin-T1 Homo sapiens 0.00036 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126551&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937080 225152898 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256455 Clc1cnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)cc1-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C28H37ClN6O2/c29-24-17-31-27(34-21-6-4-20(5-7-21)33-22-8-12-36-13-9-22)16-23(24)25-2-1-3-26(35-25)32-19-28(18-30)10-14-37-15-11-28/h1-3,16-17,20-22,33H,4-15,19H2,(H,31,34)(H,32,35)/t20-,21- MCYCQNJBYCTZFV-MEMLXQNLSA-N 126552 US8778951, 363 Cyclin-T1 Homo sapiens 0.00043 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126552&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66936833 225152899 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256456 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(F)CCOCC2)n1 InChI=1S/C25H35ClFN5O2/c1-33-14-11-28-18-5-7-19(8-6-18)31-24-15-20(21(26)16-29-24)22-3-2-4-23(32-22)30-17-25(27)9-12-34-13-10-25/h2-4,15-16,18-19,28H,5-14,17H2,1H3,(H,29,31)(H,30,32)/t18-,19- LEYXDMKGAITPJF-WGSAOQKQSA-N 126553 US8778951, 364 Cyclin-T1 Homo sapiens 0.00063 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126553&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937158 225152900 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256457 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(C)CCS(=O)(=O)CC2)n1 InChI=1S/C27H40ClN5O3S/c1-19(17-36-3)31-20-7-9-21(10-8-20)32-26-15-22(23(28)16-29-26)24-5-4-6-25(33-24)30-18-27(2)11-13-37(34,35)14-12-27/h4-6,15-16,19-21,31H,7-14,17-18H2,1-3H3,(H,29,32)(H,30,33)/t19-,20-,21-/m1/s1 YKTIFDFBLLCBJP-NJDAHSKKSA-N 126554 US8778951, 365 Cyclin-T1 Homo sapiens 0.0007 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126554&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 70794005 225152901 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256458 CCN(CC)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O/c1-3-34(4-2)21-10-8-20(9-11-21)32-26-16-22(23(28)17-30-26)24-6-5-7-25(33-24)31-19-27(18-29)12-14-35-15-13-27/h5-7,16-17,20-21H,3-4,8-15,19H2,1-2H3,(H,30,32)(H,31,33)/t20-,21- MLKMJMPHKRKDEA-MEMLXQNLSA-N 126555 US8778951, 366 Cyclin-T1 Homo sapiens 0.001 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126555&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937125 225152902 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 256459 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC(CO)CO)n1 InChI=1S/C24H35ClFN5O3/c1-15(14-34-2)29-17-3-5-18(6-4-17)30-23-9-19(20(25)11-27-23)22-8-7-21(26)24(31-22)28-10-16(12-32)13-33/h7-9,11,15-18,29,32-33H,3-6,10,12-14H2,1-2H3,(H,27,30)(H,28,31)/t15-,17-,18-/m1/s1 IOKCSWCTTWDXNS-KBAYOESNSA-N 126556 US8778951, 367 Cyclin-T1 Homo sapiens 0.0031 US Patent 10.7270/Q25B014T aid1800556 US8778951 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=996&target=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126556&enzyme=Cyclin-T1&column=ki&startPg=0&Increment=50&submit=Search 66937216 225152903 1 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 476342 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C21H22FN5O4S/c1-4-31-21(28)27-32(3,29)12-14-6-5-7-16(10-14)25-20-24-13-23-19(26-20)17-9-8-15(22)11-18(17)30-2/h5-11,13H,4,12H2,1-3H3,(H,23,24,25,26) USBSFNYHVRGRFK-UHFFFAOYSA-N 168382 US9669034, 1 (rac)-Ethyl[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168382&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618219 373987115 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476344 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) ACWKGTGIJRCOOM-UHFFFAOYSA-N 168383 US9669034, 2 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618220 373987116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476346 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) ACWKGTGIJRCOOM-UHFFFAOYSA-N 168384 US9669034, 3 (−)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168384&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618220 373987117 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476348 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) ACWKGTGIJRCOOM-UHFFFAOYSA-N 168385 US9669034, 4 (+)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine:enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168385&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618220 373987118 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476350 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccccc2)c1 InChI=1S/C27H26FN5O4S/c1-3-36-27(34)33-38(2,35)17-20-10-7-11-22(14-20)31-26-30-18-29-25(32-26)23-13-12-21(28)15-24(23)37-16-19-8-5-4-6-9-19/h4-15,18H,3,16-17H2,1-2H3,(H,29,30,31,32) XFUZGXNPSFVFEG-UHFFFAOYSA-N 168386 US9669034, 5 (rac)-Ethyl{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-1,3,5-triazin-2-yl}amino)benzyl](methyl)oxido-λ6-sulfanylidene}carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168386&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618221 373987119 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476352 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccccc2)c1 InChI=1S/C24H22FN5O2S/c1-33(26,31)15-18-8-5-9-20(12-18)29-24-28-16-27-23(30-24)21-11-10-19(25)13-22(21)32-14-17-6-3-2-4-7-17/h2-13,16,26H,14-15H2,1H3,(H,27,28,29,30) KEAPAIZOLSVRNZ-UHFFFAOYSA-N 168387 US9669034, 6 (rac)-4-[2-(Benzyloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 62 (rac)-4-(4-Fluoro-2-{[(2H5)phenyl(2H2)methyl]oxy}phenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168387&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618282 373987120 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476354 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cc(F)c(F)cc2OC)c1 InChI=1S/C21H21F2N5O4S/c1-4-32-21(29)28-33(3,30)11-13-6-5-7-14(8-13)26-20-25-12-24-19(27-20)15-9-16(22)17(23)10-18(15)31-2/h5-10,12H,4,11H2,1-3H3,(H,24,25,26,27) CQOZGXCBDBYRIV-UHFFFAOYSA-N 168388 US9669034, 9 (rac)-Ethyl[(3-{[4-(4,5-difluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168388&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618283 373987121 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476356 COc1cc(F)c(F)cc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17F2N5O2S/c1-27-16-8-15(20)14(19)7-13(16)17-22-10-23-18(25-17)24-12-5-3-4-11(6-12)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) AAEDIJKSTQIMCS-UHFFFAOYSA-N 168389 US9669034, 10 (rac)-4-(4,5-Difluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168389&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618284 373987122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476358 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(Cl)cc2OC)c1 InChI=1S/C21H22ClN5O4S/c1-4-31-21(28)27-32(3,29)12-14-6-5-7-16(10-14)25-20-24-13-23-19(26-20)17-9-8-15(22)11-18(17)30-2/h5-11,13H,4,12H2,1-3H3,(H,23,24,25,26) RAMXLDLJWVLCPG-UHFFFAOYSA-N 168390 US9669034, 11 (rac)-Ethyl[(3-{[4-(4-chloro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168390&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618076 373987123 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476360 COc1cc(Cl)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18ClN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) TWAUMQLBNMVMLO-UHFFFAOYSA-N 168391 US9669034, 12 (rac)4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 13 4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 14 4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618135 373987124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476362 COc1cc(Cl)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18ClN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) TWAUMQLBNMVMLO-UHFFFAOYSA-N 168391 US9669034, 12 (rac)4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 13 4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 14 4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618135 373987124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476364 COc1cc(Cl)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18ClN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) TWAUMQLBNMVMLO-UHFFFAOYSA-N 168391 US9669034, 12 (rac)4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 13 4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 14 4-(4-Chloro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618135 373987124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476366 CNC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C20H21FN6O3S/c1-22-20(28)27-31(3,29)11-13-5-4-6-15(9-13)25-19-24-12-23-18(26-19)16-8-7-14(21)10-17(16)30-2/h4-10,12H,11H2,1-3H3,(H,22,28)(H,23,24,25,26) ZNBYJYKSLRFMRF-UHFFFAOYSA-N 168394 US9669034, 15 (rac)-1-[(3-{[4-(4-Fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]-3-methylurea Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168394&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618136 373987125 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476368 CNC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C20H21FN6O3S/c1-22-20(28)27-31(3,29)11-13-5-4-6-15(9-13)25-19-24-12-23-18(26-19)16-8-7-14(21)10-17(16)30-2/h4-10,12H,11H2,1-3H3,(H,22,28)(H,23,24,25,26) ZNBYJYKSLRFMRF-UHFFFAOYSA-N 168395 US9669034, 16 (−)-1-[(3-{[4-(4-Fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]-3-methylurea;enantiomer1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168395&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618136 373987126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476370 CNC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C20H21FN6O3S/c1-22-20(28)27-31(3,29)11-13-5-4-6-15(9-13)25-19-24-12-23-18(26-19)16-8-7-14(21)10-17(16)30-2/h4-10,12H,11H2,1-3H3,(H,22,28)(H,23,24,25,26) ZNBYJYKSLRFMRF-UHFFFAOYSA-N 168397 US9669034, 17 (+)-1-[(3-{[4-(4-Fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]-3-methylurea;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618136 373987127 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390881 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1 InChI=1S/C20H19FN4/c1-25-11-16-18-14(15-10-13(21)2-3-17(15)25)6-9-23-20(18)24-19(16)12-4-7-22-8-5-12/h2-4,6,9-10,22H,5,7-8,11H2,1H3,(H,23,24) MBWPOBKGEBIBOJ-UHFFFAOYSA-N 223779 US9328112, 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223779&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274419 336285459 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390882 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C25H27FN4O2/c1-25(2,3)32-24(31)30-11-8-15(9-12-30)22-19-14-29(4)20-6-5-16(26)13-18(20)17-7-10-27-23(28-22)21(17)19/h5-8,10,13H,9,11-12,14H2,1-4H3,(H,27,28) LERVWHIVIHRSPH-UHFFFAOYSA-N 223780 US9328112, 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223780&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274265 336285460 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390883 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C23H24FN5O4S/c1-3-33-23(30)27-34(31,32)29-10-7-14(8-11-29)21-18-13-28(2)19-5-4-15(24)12-17(19)16-6-9-25-22(26-21)20(16)18/h4-7,9,12H,3,8,10-11,13H2,1-2H3,(H,25,26)(H,27,30) GTFKGGKFJPJKES-UHFFFAOYSA-N 223781 US9328112, 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223781&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126961688 336285461 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390884 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H21FN4O2S/c1-25-12-17-19-15(16-11-14(22)3-4-18(16)25)5-8-23-21(19)24-20(17)13-6-9-26(10-7-13)29(2,27)28/h3-6,8,11H,7,9-10,12H2,1-2H3,(H,23,24) BGYOGQNMBDFLOH-UHFFFAOYSA-N 223782 US9328112, 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223782&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274117 336285462 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390885 CS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4NCc1c23 InChI=1S/C20H19FN4O2S/c1-28(26,27)25-8-5-12(6-9-25)19-16-11-23-17-3-2-13(21)10-15(17)14-4-7-22-20(24-19)18(14)16/h2-5,7,10,23H,6,8-9,11H2,1H3,(H,22,24) IHGXDXYEPFSDRT-UHFFFAOYSA-N 223783 US9328112, 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223783&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274139 336285463 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390886 CCCN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H25FN4O2S/c1-3-10-27-14-19-21-17(18-13-16(24)4-5-20(18)27)6-9-25-23(21)26-22(19)15-7-11-28(12-8-15)31(2,29)30/h4-7,9,13H,3,8,10-12,14H2,1-2H3,(H,25,26) NCALHMHMQPGOKX-UHFFFAOYSA-N 223784 US9328112, 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223784&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274086 336285464 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390887 CS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(CC4CCOCC4)Cc1c23 InChI=1S/C26H29FN4O3S/c1-35(32,33)31-10-5-18(6-11-31)25-22-16-30(15-17-7-12-34-13-8-17)23-3-2-19(27)14-21(23)20-4-9-28-26(29-25)24(20)22/h2-5,9,14,17H,6-8,10-13,15-16H2,1H3,(H,28,29) WIFCIQYTERNBPH-UHFFFAOYSA-N 223785 US9328112, 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 800 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223785&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274267 336285465 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390888 CCC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)C(=O)OC(C)(C)C 223786 US9328112, 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1400 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223786&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274246 336285466 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390889 CCC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1 223787 US9328112, 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223787&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274280 336285467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390890 CN1C(c2cnn(C)c2)c2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1 223788 US9328112, 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223788&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274290 336285468 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390891 CCC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)S(C)(=O)=O 223789 US9328112, 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223789&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274221 336285469 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390892 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C24H26FN5O/c1-28(2)21(31)14-30-10-7-15(8-11-30)23-19-13-29(3)20-5-4-16(25)12-18(20)17-6-9-26-24(27-23)22(17)19/h4-7,9,12H,8,10-11,13-14H2,1-3H3,(H,26,27) YADQLVURPMYFRT-UHFFFAOYSA-N 223790 US9328112, 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223790&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274335 336285470 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390893 CNC(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C22H22FN5O/c1-24-22(29)28-9-6-13(7-10-28)20-17-12-27(2)18-4-3-14(23)11-16(18)15-5-8-25-21(26-20)19(15)17/h3-6,8,11H,7,9-10,12H2,1-2H3,(H,24,29)(H,25,26) OOBCSTPOVIWGJF-UHFFFAOYSA-N 223791 US9328112, 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223791&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274298 336285471 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390894 Fc1ccc2OCc3c([nH]c4nccc(-c2c1)c34)C1=CCNCC1 InChI=1S/C19H16FN3O/c20-12-1-2-16-14(9-12)13-5-8-22-19-17(13)15(10-24-16)18(23-19)11-3-6-21-7-4-11/h1-3,5,8-9,21H,4,6-7,10H2,(H,22,23) JYMZJHHWSVAPHQ-UHFFFAOYSA-N 223792 US9328112, 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223792&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 91827449 336285472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390895 CS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4OCc1c23 InChI=1S/C20H18FN3O3S/c1-28(25,26)24-8-5-12(6-9-24)19-16-11-27-17-3-2-13(21)10-15(17)14-4-7-22-20(23-19)18(14)16/h2-5,7,10H,6,8-9,11H2,1H3,(H,22,23) MLJOUDSMTMFDIF-UHFFFAOYSA-N 223793 US9328112, 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223793&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274397 336285473 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390896 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H21FN4O2/c1-26-11-17-20-15(16-10-14(23)2-3-18(16)26)4-7-24-22(20)25-21(17)13-5-8-27(9-6-13)12-19(28)29/h2-5,7,10H,6,8-9,11-12H2,1H3,(H,24,25)(H,28,29) DOAYWLKCUCRUGU-UHFFFAOYSA-N 223794 US9328112, 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223794&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274361 336285474 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390897 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-13-18(28)4-5-23(21)31)6-9-29-27(25)30-26(22)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-7,9,13,19,34H,2-3,8,10-12,14-16H2,1H3,(H,29,30)/t19-/m0/s1 IQDTYCFAMDXAPG-IBGZPJMESA-N 223795 US9328112, 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223795&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274473 336285475 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390898 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H26FN5O2/c1-29-13-20-23-18(19-10-16(26)2-3-21(19)29)4-7-27-25(23)28-24(20)15-5-8-30(9-6-15)14-22(33)31-11-17(32)12-31/h2-5,7,10,17,32H,6,8-9,11-14H2,1H3,(H,27,28) UQAUOQQDIKLCFH-UHFFFAOYSA-N 223796 US9328112, 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223796&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274253 336285476 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390899 CN(CCO)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C25H28FN5O2/c1-29(11-12-32)22(33)15-31-9-6-16(7-10-31)24-20-14-30(2)21-4-3-17(26)13-19(21)18-5-8-27-25(28-24)23(18)20/h3-6,8,13,32H,7,9-12,14-15H2,1-2H3,(H,27,28) UVFUDTVXNLZEOK-UHFFFAOYSA-N 223797 US9328112, 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223797&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274518 336285477 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390900 CC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)S(C)(=O)=O 223798 US9328112, 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223798&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274367 336285478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390901 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCNCC1 InChI=1S/C20H21FN4/c1-25-11-16-18-14(15-10-13(21)2-3-17(15)25)6-9-23-20(18)24-19(16)12-4-7-22-8-5-12/h2-3,6,9-10,12,22H,4-5,7-8,11H2,1H3,(H,23,24) RYCUFYDCYDPQLV-UHFFFAOYSA-N 223799 US9328112, 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 400 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223799&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274486 336285479 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390902 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCN(CC(=O)OC(C)(C)C)CC1 InChI=1S/C26H31FN4O2/c1-26(2,3)33-22(32)15-31-11-8-16(9-12-31)24-20-14-30(4)21-6-5-17(27)13-19(21)18-7-10-28-25(29-24)23(18)20/h5-7,10,13,16H,8-9,11-12,14-15H2,1-4H3,(H,28,29) SFQNPNYUQPTUMF-UHFFFAOYSA-N 223800 US9328112, 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2800 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223800&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126961689 336285480 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390903 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCN(CC(O)=O)CC1 InChI=1S/C22H23FN4O2/c1-26-11-17-20-15(16-10-14(23)2-3-18(16)26)4-7-24-22(20)25-21(17)13-5-8-27(9-6-13)12-19(28)29/h2-4,7,10,13H,5-6,8-9,11-12H2,1H3,(H,24,25)(H,28,29) AMGGPCZGBCXQDX-UHFFFAOYSA-N 223801 US9328112, 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223801&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274439 336285481 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390904 CN(C1CC(O)C1)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-11-17(28)3-4-23(21)31)5-8-29-27(25)30-26(22)16-6-9-33(10-7-16)15-24(35)32(2)18-12-19(34)13-18/h3-6,8,11,18-19,34H,7,9-10,12-15H2,1-2H3,(H,29,30) YFPPHYORWWDDQJ-UHFFFAOYSA-N 223802 US9328112, 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223802&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274468 336285482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390905 CNS(=O)(=O)CC(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C23H24FN5O3S/c1-25-33(31,32)13-20(30)29-9-6-14(7-10-29)22-18-12-28(2)19-4-3-15(24)11-17(19)16-5-8-26-23(27-22)21(16)18/h3-6,8,11,25H,7,9-10,12-13H2,1-2H3,(H,26,27) JZVAAEYRYPYICS-UHFFFAOYSA-N 223803 US9328112, 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223803&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274490 336285483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390906 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H32FN5O2/c1-31-14-22-25-20(21-13-18(28)4-5-23(21)31)6-9-29-27(25)30-26(22)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-6,9,13,17,19,34H,2-3,7-8,10-12,14-16H2,1H3,(H,29,30)/t19-/m0/s1 LIBNIRJBYKYJMU-IBGZPJMESA-N 223804 US9328112, 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223804&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274182 336285484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390907 CN(CCO)C(=O)CN1CCC(CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C25H30FN5O2/c1-29(11-12-32)22(33)15-31-9-6-16(7-10-31)24-20-14-30(2)21-4-3-17(26)13-19(21)18-5-8-27-25(28-24)23(18)20/h3-5,8,13,16,32H,6-7,9-12,14-15H2,1-2H3,(H,27,28) RSGWDLYLYNWZJR-UHFFFAOYSA-N 223805 US9328112, 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223805&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274110 336285485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390908 CCOC(=O)C1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1 223806 US9328112, 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223806&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274135 336285486 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390909 CC(C)[C@@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O InChI=1S/C26H29FN4O2/c1-14(2)23(26(32)33)29-17-7-4-15(5-8-17)24-20-13-31(3)21-9-6-16(27)12-19(21)18-10-11-28-25(30-24)22(18)20/h4,6,9-12,14,17,23,29H,5,7-8,13H2,1-3H3,(H,28,30)(H,32,33)/t17?,23-/m1/s1 GQIQALPJWJORRV-IRCUZVAFSA-N 223807 US9328112, 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223807&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274354 336285487 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390910 C[C@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O InChI=1S/C24H25FN4O2/c1-13(24(30)31)27-16-6-3-14(4-7-16)22-19-12-29(2)20-8-5-15(25)11-18(20)17-9-10-26-23(28-22)21(17)19/h3,5,8-11,13,16,27H,4,6-7,12H2,1-2H3,(H,26,28)(H,30,31)/t13-,16?/m0/s1 IHXXNIJMUIHGBG-KNVGNIICSA-N 223808 US9328112, 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223808&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274166 336285488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390911 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)NCC(O)=O 223809 US9328112, 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223809&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274432 336285489 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390912 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@H](C(O)=O)c1ccccc1 InChI=1S/C29H27FN4O2/c1-34-16-23-25-21(22-15-19(30)9-12-24(22)34)13-14-31-28(25)33-26(23)18-7-10-20(11-8-18)32-27(29(35)36)17-5-3-2-4-6-17/h2-7,9,12-15,20,27,32H,8,10-11,16H2,1H3,(H,31,33)(H,35,36)/t20?,27-/m0/s1 ZXFICJYRNVXIPM-OHMHCFLMSA-N 223810 US9328112, 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223810&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274275 336285490 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390913 CN1C(C(O)=O)c2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1 223811 US9328112, 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 540 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223811&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274472 336285491 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390914 CC(C)[C@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O InChI=1S/C26H29FN4O2/c1-14(2)23(26(32)33)29-17-7-4-15(5-8-17)24-20-13-31(3)21-9-6-16(27)12-19(21)18-10-11-28-25(30-24)22(18)20/h4,6,9-12,14,17,23,29H,5,7-8,13H2,1-3H3,(H,28,30)(H,32,33)/t17?,23-/m0/s1 GQIQALPJWJORRV-VXLWULRPSA-N 223812 US9328112, 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223812&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274145 336285492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390915 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@@H](Cc1ccccc1)C(O)=O InChI=1S/C30H29FN4O2/c1-35-17-24-27-22(23-16-20(31)9-12-26(23)35)13-14-32-29(27)34-28(24)19-7-10-21(11-8-19)33-25(30(36)37)15-18-5-3-2-4-6-18/h2-7,9,12-14,16,21,25,33H,8,10-11,15,17H2,1H3,(H,32,34)(H,36,37)/t21?,25-/m0/s1 WPCIOQQZRUJPNC-QBGQUKIHSA-N 223813 US9328112, 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223813&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274394 336285493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390916 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@H](C(O)=O)C(C)(C)C InChI=1S/C27H31FN4O2/c1-27(2,3)24(26(33)34)30-17-8-5-15(6-9-17)23-20-14-32(4)21-10-7-16(28)13-19(21)18-11-12-29-25(31-23)22(18)20/h5,7,10-13,17,24,30H,6,8-9,14H2,1-4H3,(H,29,31)(H,33,34)/t17?,24-/m1/s1 HEZUVGQTKMXSOH-FZYLFJGDSA-N 223814 US9328112, 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223814&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274219 336285494 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390917 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N1CCC[C@H]1C(O)=O InChI=1S/C26H27FN4O2/c1-30-14-20-23-18(19-13-16(27)6-9-21(19)30)10-11-28-25(23)29-24(20)15-4-7-17(8-5-15)31-12-2-3-22(31)26(32)33/h4,6,9-11,13,17,22H,2-3,5,7-8,12,14H2,1H3,(H,28,29)(H,32,33)/t17?,22-/m0/s1 KDNCPLRMCCZRCQ-UGNFMNBCSA-N 223815 US9328112, 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223815&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274293 336285495 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390918 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@@H](CO)C(O)=O InChI=1S/C24H25FN4O3/c1-29-11-18-21-16(17-10-14(25)4-7-20(17)29)8-9-26-23(21)28-22(18)13-2-5-15(6-3-13)27-19(12-30)24(31)32/h2,4,7-10,15,19,27,30H,3,5-6,11-12H2,1H3,(H,26,28)(H,31,32)/t15?,19-/m0/s1 KRYAATXONPODKV-FUBQLUNQSA-N 223816 US9328112, 38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223816&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274100 336285496 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390919 CCC[C@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O InChI=1S/C26H29FN4O2/c1-3-4-21(26(32)33)29-17-8-5-15(6-9-17)24-20-14-31(2)22-10-7-16(27)13-19(22)18-11-12-28-25(30-24)23(18)20/h5,7,10-13,17,21,29H,3-4,6,8-9,14H2,1-2H3,(H,28,30)(H,32,33)/t17?,21-/m0/s1 XRFDZWZYBHQHOZ-LFABVHOISA-N 223817 US9328112, 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274380 336285497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390920 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@@H](Cc1ccc(O)cc1)C(O)=O InChI=1S/C30H29FN4O3/c1-35-16-24-27-22(23-15-19(31)6-11-26(23)35)12-13-32-29(27)34-28(24)18-4-7-20(8-5-18)33-25(30(37)38)14-17-2-9-21(36)10-3-17/h2-4,6,9-13,15,20,25,33,36H,5,7-8,14,16H2,1H3,(H,32,34)(H,37,38)/t20?,25-/m0/s1 XRXOBXSKWYGBPZ-KUXBLMNESA-N 223818 US9328112, 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274453 336285498 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390921 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)C(O)=O 223819 US9328112, 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223819&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274402 336285499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390922 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC[C@H](O)C2)CC1 InChI=1S/C26H28FN5O2/c1-30-14-21-24-19(20-12-17(27)2-3-22(20)30)4-8-28-26(24)29-25(21)16-5-9-31(10-6-16)15-23(34)32-11-7-18(33)13-32/h2-5,8,12,18,33H,6-7,9-11,13-15H2,1H3,(H,28,29)/t18-/m0/s1 CABZALQAXHTXKD-SFHVURJKSA-N 223820 US9328112, 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223820&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274314 336285500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390923 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(cc1)S(C)(=O)=O InChI=1S/C22H18FN3O2S/c1-26-12-18-20-16(17-11-14(23)5-8-19(17)26)9-10-24-22(20)25-21(18)13-3-6-15(7-4-13)29(2,27)28/h3-11H,12H2,1-2H3,(H,24,25) LWNPTVWSJDFFBJ-UHFFFAOYSA-N 223821 US9328112, 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223821&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274501 336285501 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390924 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccncc1 InChI=1S/C20H15FN4/c1-25-11-16-18-14(15-10-13(21)2-3-17(15)25)6-9-23-20(18)24-19(16)12-4-7-22-8-5-12/h2-10H,11H2,1H3,(H,23,24) QOVCDHQALDDWQV-UHFFFAOYSA-N 223822 US9328112, 44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223822&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274436 336285502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390925 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(nc1)S(C)(=O)=O InChI=1S/C21H17FN4O2S/c1-26-11-16-19-14(15-9-13(22)4-5-17(15)26)7-8-23-21(19)25-20(16)12-3-6-18(24-10-12)29(2,27)28/h3-10H,11H2,1-2H3,(H,23,25) CQTIMMHXSUPUFQ-UHFFFAOYSA-N 223823 US9328112, 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223823&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274452 336285503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390926 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1cnc(N)nc1 InChI=1S/C19H15FN6/c1-26-9-14-16-12(13-6-11(20)2-3-15(13)26)4-5-22-18(16)25-17(14)10-7-23-19(21)24-8-10/h2-8H,9H2,1H3,(H,22,25)(H2,21,23,24) XIMUBIIIERJMBZ-UHFFFAOYSA-N 223824 US9328112, 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3300 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223824&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274108 336285504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390927 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(cc1)C(O)=O InChI=1S/C22H16FN3O2/c1-26-11-17-19-15(16-10-14(23)6-7-18(16)26)8-9-24-21(19)25-20(17)12-2-4-13(5-3-12)22(27)28/h2-10H,11H2,1H3,(H,24,25)(H,27,28) ZCRCJNNWANICIL-UHFFFAOYSA-N 223825 US9328112, 47 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223825&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274409 336285505 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390928 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCNCC1 InChI=1S/C20H18F2N4/c1-26-10-14-18-17(13-8-12(21)2-3-16(13)26)15(22)9-24-20(18)25-19(14)11-4-6-23-7-5-11/h2-4,8-9,23H,5-7,10H2,1H3,(H,24,25) PXWMAYRKENVODH-UHFFFAOYSA-N 223826 US9328112, 48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223826&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274130 336285506 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390929 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C25H26F2N4O2/c1-25(2,3)33-24(32)31-9-7-14(8-10-31)22-17-13-30(4)19-6-5-15(26)11-16(19)20-18(27)12-28-23(29-22)21(17)20/h5-7,11-12H,8-10,13H2,1-4H3,(H,28,29) PGJMVQLKLTWQPD-UHFFFAOYSA-N 223827 US9328112, 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 780 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223827&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274277 336285507 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390930 CN(C)C(=O)C1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223828 US9328112, 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223828&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274515 336285508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390931 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)C(=O)N1CC(O)C1 223829 US9328112, 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223829&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274119 336285509 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390932 CNC(=O)C1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223830 US9328112, 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223830&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274302 336285510 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390933 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N(CCO)CCO)CC1 InChI=1S/C26H30FN5O3/c1-30-15-21-24-19(20-14-18(27)2-3-22(20)30)4-7-28-26(24)29-25(21)17-5-8-31(9-6-17)16-23(35)32(10-12-33)11-13-34/h2-5,7,14,33-34H,6,8-13,15-16H2,1H3,(H,28,29) PDRCEIHQPSQNRM-UHFFFAOYSA-N 223831 US9328112, 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223831&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274258 336285511 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390934 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(F)(F)C2)CC1 InChI=1S/C25H24F3N5O/c1-31-11-19-22-17(18-10-16(26)2-3-20(18)31)4-7-29-24(22)30-23(19)15-5-8-32(9-6-15)12-21(34)33-13-25(27,28)14-33/h2-5,7,10H,6,8-9,11-14H2,1H3,(H,29,30) LTHLOZPTAOJDEJ-UHFFFAOYSA-N 223832 US9328112, 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223832&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274228 336285512 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390935 CN(C)C(=O)CN1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C26H28FN5O/c1-30(2)23(33)14-32-17-5-6-18(32)11-15(10-17)25-21-13-31(3)22-7-4-16(27)12-20(22)19-8-9-28-26(29-25)24(19)21/h4,7-10,12,17-18H,5-6,11,13-14H2,1-3H3,(H,28,29)/t17-,18+/m1/s1 NJIBQOZKOJEPQX-MSOLQXFVSA-N 223833 US9328112, 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223833&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274197 336285513 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390936 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2S(C)(=O)=O InChI=1S/C23H23FN4O2S/c1-27-12-19-21-17(18-11-14(24)3-6-20(18)27)7-8-25-23(21)26-22(19)13-9-15-4-5-16(10-13)28(15)31(2,29)30/h3,6-9,11,15-16H,4-5,10,12H2,1-2H3,(H,25,26)/t15-,16+/m1/s1 WTROHPXYJKMSCL-CVEARBPZSA-N 223834 US9328112, 56 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223834&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274198 336285514 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390937 CNC(=O)N1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C24H24FN5O/c1-26-24(31)30-15-4-5-16(30)10-13(9-15)22-19-12-29(2)20-6-3-14(25)11-18(20)17-7-8-27-23(28-22)21(17)19/h3,6-9,11,15-16H,4-5,10,12H2,1-2H3,(H,26,31)(H,27,28)/t15-,16+/m1/s1 QYIGMXPNCQBARP-CVEARBPZSA-N 223835 US9328112, 57 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223835&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274512 336285515 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390938 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2CC(O)=O InChI=1S/C24H23FN4O2/c1-28-11-19-22-17(18-10-14(25)2-5-20(18)28)6-7-26-24(22)27-23(19)13-8-15-3-4-16(9-13)29(15)12-21(30)31/h2,5-8,10,15-16H,3-4,9,11-12H2,1H3,(H,26,27)(H,30,31)/t15-,16+/m1/s1 XLRQZTUNWNIGSH-CVEARBPZSA-N 223836 US9328112, 58 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223836&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274105 336285516 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390939 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CNCC2C1 223837 US9328112, 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223837&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274378 336285517 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390940 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1cccnc1 InChI=1S/C20H15FN4/c1-25-11-16-18-14(15-9-13(21)4-5-17(15)25)6-8-23-20(18)24-19(16)12-3-2-7-22-10-12/h2-10H,11H2,1H3,(H,23,24) KLQYIUYHOZFZEP-UHFFFAOYSA-N 223838 US9328112, 60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223838&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274176 336285518 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390941 CCOC(=O)C1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223839 US9328112, 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 400 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223839&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274242 336285519 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390942 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2 InChI=1S/C22H21FN4/c1-27-11-18-20-16(17-10-13(23)2-5-19(17)27)6-7-24-22(20)26-21(18)12-8-14-3-4-15(9-12)25-14/h2,5-8,10,14-15,25H,3-4,9,11H2,1H3,(H,24,26)/t14-,15+/m1/s1 UQWVCOXGMZOGMW-CABCVRRESA-N 223840 US9328112, 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223840&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274462 336285520 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390943 CN(CC(O)CO)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223841 US9328112, 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223841&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274386 336285521 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390944 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@@H]2CO)CC1 InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-13-18(28)4-5-23(21)31)6-9-29-27(25)30-26(22)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-7,9,13,19,34H,2-3,8,10-12,14-16H2,1H3,(H,29,30)/t19-/m1/s1 IQDTYCFAMDXAPG-LJQANCHMSA-N 223842 US9328112, 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223842&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274404 336285522 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390945 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)OC(C)(C)C)CC1 InChI=1S/C26H28F2N4O2/c1-26(2,3)34-21(33)14-32-9-7-15(8-10-32)24-18-13-31(4)20-6-5-16(27)11-17(20)22-19(28)12-29-25(30-24)23(18)22/h5-7,11-12H,8-10,13-14H2,1-4H3,(H,29,30) WEEAWLKHRITTEL-UHFFFAOYSA-N 223843 US9328112, 65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223843&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126961690 336285523 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390946 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C24H25F2N5O/c1-29(2)20(32)13-31-8-6-14(7-9-31)23-17-12-30(3)19-5-4-15(25)10-16(19)21-18(26)11-27-24(28-23)22(17)21/h4-6,10-11H,7-9,12-13H2,1-3H3,(H,27,28) LNXRZRBGYSWLAU-UHFFFAOYSA-N 223844 US9328112, 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223844&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274141 336285524 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390947 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H20F2N4O2/c1-27-10-15-20-19(14-8-13(23)2-3-17(14)27)16(24)9-25-22(20)26-21(15)12-4-6-28(7-5-12)11-18(29)30/h2-4,8-9H,5-7,10-11H2,1H3,(H,25,26)(H,29,30) WWXDJWZRVYVGGP-UHFFFAOYSA-N 223845 US9328112, 67 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223845&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274236 336285525 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390948 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H20F2N4O2S/c1-26-11-15-19-18(14-9-13(22)3-4-17(14)26)16(23)10-24-21(19)25-20(15)12-5-7-27(8-6-12)30(2,28)29/h3-5,9-10H,6-8,11H2,1-2H3,(H,24,25) MPDNJXVRMNMVQV-UHFFFAOYSA-N 223846 US9328112, 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223846&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274124 336285526 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390949 COCCS(=O)(=O)N1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223847 US9328112, 69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223847&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274456 336285527 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390950 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H29F2N5O2/c1-32-13-20-25-24(19-11-17(28)4-5-22(19)32)21(29)12-30-27(25)31-26(20)16-6-9-33(10-7-16)14-23(36)34-8-2-3-18(34)15-35/h4-6,11-12,18,35H,2-3,7-10,13-15H2,1H3,(H,30,31)/t18-/m0/s1 WUMKFHVFUATEHZ-SFHVURJKSA-N 223848 US9328112, 70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223848&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274104 336285528 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390951 CN(CCO)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C25H27F2N5O2/c1-30(9-10-33)21(34)14-32-7-5-15(6-8-32)24-18-13-31(2)20-4-3-16(26)11-17(20)22-19(27)12-28-25(29-24)23(18)22/h3-5,11-12,33H,6-10,13-14H2,1-2H3,(H,28,29) SWAFXDQVRSHLJG-UHFFFAOYSA-N 223849 US9328112, 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223849&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274467 336285529 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390952 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H25F2N5O2/c1-30-12-18-23-22(17-8-15(26)2-3-20(17)30)19(27)9-28-25(23)29-24(18)14-4-6-31(7-5-14)13-21(34)32-10-16(33)11-32/h2-4,8-9,16,33H,5-7,10-13H2,1H3,(H,28,29) FZWDKADYZJATSC-UHFFFAOYSA-N 223850 US9328112, 72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223850&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274088 336285530 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390953 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC[C@H](O)C2)CC1 InChI=1S/C26H27F2N5O2/c1-31-13-19-24-23(18-10-16(27)2-3-21(18)31)20(28)11-29-26(24)30-25(19)15-4-7-32(8-5-15)14-22(35)33-9-6-17(34)12-33/h2-4,10-11,17,34H,5-9,12-14H2,1H3,(H,29,30)/t17-/m0/s1 XOJFSJZIMLWUNB-KRWDZBQOSA-N 223851 US9328112, 73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223851&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274499 336285531 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390954 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(CO)C2)CC1 InChI=1S/C26H27F2N5O2/c1-31-12-19-24-23(18-8-17(27)2-3-21(18)31)20(28)9-29-26(24)30-25(19)16-4-6-32(7-5-16)13-22(35)33-10-15(11-33)14-34/h2-4,8-9,15,34H,5-7,10-14H2,1H3,(H,29,30) SBTSKCTUCNRHFQ-UHFFFAOYSA-N 223852 US9328112, 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223852&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274478 336285532 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390955 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@@H]2CO)CC1 InChI=1S/C27H29F2N5O2/c1-32-13-20-25-24(19-11-17(28)4-5-22(19)32)21(29)12-30-27(25)31-26(20)16-6-9-33(10-7-16)14-23(36)34-8-2-3-18(34)15-35/h4-6,11-12,18,35H,2-3,7-10,13-15H2,1H3,(H,30,31)/t18-/m1/s1 WUMKFHVFUATEHZ-GOSISDBHSA-N 223853 US9328112, 75 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223853&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274163 336285533 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390956 CNC(=O)N1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223854 US9328112, 76 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223854&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274190 336285534 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390957 CN(C)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223855 US9328112, 77 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274424 336285535 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390958 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CN(CC2C1)S(C)(=O)=O 223856 US9328112, 78 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223856&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274271 336285536 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390959 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2CC(=O)N1CCC[C@H]1CO InChI=1S/C29H32FN5O2/c1-33-14-24-27-22(23-13-18(30)4-7-25(23)33)8-9-31-29(27)32-28(24)17-11-19-5-6-20(12-17)35(19)15-26(37)34-10-2-3-21(34)16-36/h4,7-9,11,13,19-21,36H,2-3,5-6,10,12,14-16H2,1H3,(H,31,32)/t19-,20+,21+/m1/s1 KEZFWKJBYSICBS-HKBOAZHASA-N 223857 US9328112, 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 72 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223857&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274149 336285537 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390960 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2CC(=O)N1CC(O)C1 InChI=1S/C27H28FN5O2/c1-31-13-22-25-20(21-10-16(28)2-5-23(21)31)6-7-29-27(25)30-26(22)15-8-17-3-4-18(9-15)33(17)14-24(35)32-11-19(34)12-32/h2,5-8,10,17-19,34H,3-4,9,11-14H2,1H3,(H,29,30)/t17-,18+/m1/s1 IHQFQWDCUSTFDK-MSOLQXFVSA-N 223858 US9328112, 80 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223858&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274307 336285538 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390961 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(CC(O)=O)cc1 InChI=1S/C23H18FN3O2/c1-27-12-18-21-16(17-11-15(24)6-7-19(17)27)8-9-25-23(21)26-22(18)14-4-2-13(3-5-14)10-20(28)29/h2-9,11H,10,12H2,1H3,(H,25,26)(H,28,29) VGYKCNXWHQDKFY-UHFFFAOYSA-N 223859 US9328112, 81 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223859&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274308 336285539 C03768 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390962 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1cccc(CC(O)=O)c1 InChI=1S/C23H18FN3O2/c1-27-12-18-21-16(17-11-15(24)5-6-19(17)27)7-8-25-23(21)26-22(18)14-4-2-3-13(9-14)10-20(28)29/h2-9,11H,10,12H2,1H3,(H,25,26)(H,28,29) WRRRMAGKSDWTQC-UHFFFAOYSA-N 223860 US9328112, 82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223860&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274170 336285540 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390963 CN(CC(O)CO)C(=O)CN1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C28H32FN5O3/c1-32-13-23-26-21(22-11-17(29)3-6-24(22)32)7-8-30-28(26)31-27(23)16-9-18-4-5-19(10-16)34(18)14-25(37)33(2)12-20(36)15-35/h3,6-9,11,18-20,35-36H,4-5,10,12-15H2,1-2H3,(H,30,31)/t18-,19+,20?/m1/s1 SNFNPJOYYQCLAV-LFPSWIHMSA-N 223861 US9328112, 83 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223861&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274167 336285541 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390964 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CN(CC(=O)N3CC(O)C3)CC2C1 223862 US9328112, 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223862&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274213 336285542 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390965 CN(CC(O)CO)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223863 US9328112, 85 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223863&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274305 336285543 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390966 CN(CCO)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223864 US9328112, 86 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223864&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274403 336285544 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390967 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCNCC1 InChI=1S/C21H21FN4/c1-26-12-17-19-15(16-11-14(22)4-5-18(16)26)7-10-24-21(19)25-20(17)13-3-2-8-23-9-6-13/h3-5,7,10-11,23H,2,6,8-9,12H2,1H3,(H,24,25) RYFCUPWDDVRSSU-UHFFFAOYSA-N 223865 US9328112, 87 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223865&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274189 336285545 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390968 CN(C)C(=O)CN1CCC=C(CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C25H28FN5O/c1-29(2)22(32)15-31-11-4-5-16(9-12-31)24-20-14-30(3)21-7-6-17(26)13-19(21)18-8-10-27-25(28-24)23(18)20/h5-8,10,13H,4,9,11-12,14-15H2,1-3H3,(H,27,28) PGGPSVOCGMXPRT-UHFFFAOYSA-N 223866 US9328112, 88 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223866&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274504 336285546 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390969 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC1)S(C)(=O)=O InChI=1S/C22H23FN4O2S/c1-26-13-18-20-16(17-12-15(23)5-6-19(17)26)7-9-24-22(20)25-21(18)14-4-3-10-27(11-8-14)30(2,28)29/h4-7,9,12H,3,8,10-11,13H2,1-2H3,(H,24,25) PVBBXUAYGHOKQV-UHFFFAOYSA-N 223867 US9328112, 89 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223867&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274463 336285547 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390970 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(O)=O)CC1 InChI=1S/C23H23FN4O2/c1-27-12-18-21-16(17-11-15(24)4-5-19(17)27)6-8-25-23(21)26-22(18)14-3-2-9-28(10-7-14)13-20(29)30/h3-6,8,11H,2,7,9-10,12-13H2,1H3,(H,25,26)(H,29,30) SBEZNEYQRVAHOI-UHFFFAOYSA-N 223868 US9328112, 90 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223868&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274121 336285548 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390971 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C26H28FN5O2/c1-30-14-21-24-19(20-11-17(27)4-5-22(20)30)6-8-28-26(24)29-25(21)16-3-2-9-31(10-7-16)15-23(34)32-12-18(33)13-32/h3-6,8,11,18,33H,2,7,9-10,12-15H2,1H3,(H,28,29) KFGMMTWPUPBJKX-UHFFFAOYSA-N 223869 US9328112, 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223869&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274496 336285549 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390972 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1(C)C InChI=1S/C22H23FN4/c1-22(2)12-24-8-7-17(22)20-16-11-27(3)18-5-4-13(23)10-15(18)14-6-9-25-21(26-20)19(14)16/h4-7,9-10,24H,8,11-12H2,1-3H3,(H,25,26) YQOWAASGACHAEC-UHFFFAOYSA-N 223870 US9328112, 92 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 420 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223870&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274255 336285550 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390973 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCNC1 InChI=1S/C20H19FN4/c1-25-11-16-18-14(15-9-13(21)4-5-17(15)25)6-8-23-20(18)24-19(16)12-3-2-7-22-10-12/h3-6,8-9,22H,2,7,10-11H2,1H3,(H,23,24) QVRCZQQYAVLEKP-UHFFFAOYSA-N 223871 US9328112, 93 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223871&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274317 336285551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390974 CN(C1CC(O)C1)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223872 US9328112, 94 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223872&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274203 336285552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390975 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(C1)S(C)(=O)=O InChI=1S/C21H21FN4O2S/c1-25-12-17-19-15(16-10-14(22)5-6-18(16)25)7-8-23-21(19)24-20(17)13-4-3-9-26(11-13)29(2,27)28/h4-8,10H,3,9,11-12H2,1-2H3,(H,23,24) KPWISPLSYOSJLL-UHFFFAOYSA-N 223873 US9328112, 95 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223873&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274160 336285553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390976 CNC(=O)N1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C22H22FN5O/c1-24-22(29)28-9-3-4-13(11-28)20-17-12-27(2)18-6-5-14(23)10-16(18)15-7-8-25-21(26-20)19(15)17/h4-8,10H,3,9,11-12H2,1-2H3,(H,24,29)(H,25,26) JQGLEIFMEICBDT-UHFFFAOYSA-N 223874 US9328112, 96 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223874&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274375 336285554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390977 CN(C)C(=O)CN1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C24H26FN5O/c1-28(2)21(31)14-30-10-4-5-15(12-30)23-19-13-29(3)20-7-6-16(25)11-18(20)17-8-9-26-24(27-23)22(17)19/h5-9,11H,4,10,12-14H2,1-3H3,(H,26,27) UNDAAOCZXBUKJT-UHFFFAOYSA-N 223875 US9328112, 97 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 420 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223875&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274392 336285555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390978 CN(C1CC(O)C1)C(=O)CN1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C29H32FN5O2/c1-33-14-24-27-22(23-11-17(30)3-6-25(23)33)7-8-31-29(27)32-28(24)16-9-18-4-5-19(10-16)35(18)15-26(37)34(2)20-12-21(36)13-20/h3,6-9,11,18-21,36H,4-5,10,12-15H2,1-2H3,(H,31,32)/t18-,19+,20?,21?/m1/s1 NHCOQDKLHZKQEK-QAJIEZEQSA-N 223876 US9328112, 98 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223876&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274349 336285556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390979 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2S(C)(=O)=O 223877 US9328112, 99 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 400 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223877&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274211 336285557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390980 CNC(=O)N1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223878 US9328112, 100 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274334 336285558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390981 CN(C)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223879 US9328112, 101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223879&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274239 336285559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390982 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2C(=O)CC#N 223880 US9328112, 102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223880&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274216 336285560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390983 CN(CCO)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223881 US9328112, 103 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223881&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274408 336285561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390984 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2CC(=O)N1CCC[C@H]1CO InChI=1S/C30H34FN5O2/c1-34-15-25-28-23(24-14-19(31)7-8-26(24)34)9-10-32-30(28)33-29(25)18-12-20-4-2-5-21(13-18)36(20)16-27(38)35-11-3-6-22(35)17-37/h7-10,12,14,20-22,37H,2-6,11,13,15-17H2,1H3,(H,32,33)/t20?,21?,22-/m0/s1 XTONEYLUHWBDST-HRTMPFAESA-N 223882 US9328112, 104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223882&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274074 336285562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390985 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2CC(=O)N1CC(O)C1 223883 US9328112, 105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274440 336285563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390986 CN(C1CC(O)C1)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223884 US9328112, 106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223884&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274430 336285564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390987 CN(CC(O)CO)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223885 US9328112, 107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274328 336285565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390988 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2CC(O)=O 223886 US9328112, 108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223886&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274207 336285566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390989 CN(C1CC(O)C1)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C27H29F2N5O2/c1-32-13-20-25-24(19-9-16(28)3-4-22(19)32)21(29)12-30-27(25)31-26(20)15-5-7-34(8-6-15)14-23(36)33(2)17-10-18(35)11-17/h3-5,9,12,17-18,35H,6-8,10-11,13-14H2,1-2H3,(H,30,31) UDBBZTHWNIYKKS-UHFFFAOYSA-N 223887 US9328112, 109 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223887&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274447 336285567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390990 CN(CC(O)CO)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23 223888 US9328112, 110 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223888&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274185 336285568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390991 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(O)=O)CC1(C)C InChI=1S/C24H25FN4O2/c1-24(2)13-29(12-20(30)31)9-7-18(24)22-17-11-28(3)19-5-4-14(25)10-16(19)15-6-8-26-23(27-22)21(15)17/h4-8,10H,9,11-13H2,1-3H3,(H,26,27)(H,30,31) VMVJAORWJKMLIK-UHFFFAOYSA-N 223889 US9328112, 111 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1600 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223889&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274418 336285569 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390992 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(O)=O)C1 InChI=1S/C22H21FN4O2/c1-26-11-17-20-15(16-9-14(23)4-5-18(16)26)6-7-24-22(20)25-21(17)13-3-2-8-27(10-13)12-19(28)29/h3-7,9H,2,8,10-12H2,1H3,(H,24,25)(H,28,29) LIGGJWGBNCKOQH-UHFFFAOYSA-N 223890 US9328112, 112 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223890&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274491 336285570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390993 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1(C)C)S(C)(=O)=O InChI=1S/C23H25FN4O2S/c1-23(2)13-28(31(4,29)30)10-8-18(23)21-17-12-27(3)19-6-5-14(24)11-16(19)15-7-9-25-22(26-21)20(15)17/h5-9,11H,10,12-13H2,1-4H3,(H,25,26) PCPKQKXNEAXBTK-UHFFFAOYSA-N 223891 US9328112, 113 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 650 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223891&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274366 336285571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390994 CN(C)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1 InChI=1S/C26H30FN5O/c1-26(2)15-32(14-22(33)30(3)4)11-9-20(26)24-19-13-31(5)21-7-6-16(27)12-18(21)17-8-10-28-25(29-24)23(17)19/h6-10,12H,11,13-15H2,1-5H3,(H,28,29) VYBYOLOBVGPCHH-UHFFFAOYSA-N 223892 US9328112, 114 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 870 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223892&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274080 336285572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390995 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1(C)C InChI=1S/C29H34FN5O2/c1-29(2)17-34(15-25(37)35-11-4-5-19(35)16-36)12-9-23(29)27-22-14-33(3)24-7-6-18(30)13-21(24)20-8-10-31-28(32-27)26(20)22/h6-10,13,19,36H,4-5,11-12,14-17H2,1-3H3,(H,31,32)/t19-/m0/s1 PIILQBHQCWAHQJ-IBGZPJMESA-N 223893 US9328112, 115 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 950 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223893&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274448 336285573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390996 CN(CCO)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1 InChI=1S/C27H32FN5O2/c1-27(2)16-33(15-23(35)31(3)11-12-34)10-8-21(27)25-20-14-32(4)22-6-5-17(28)13-19(22)18-7-9-29-26(30-25)24(18)20/h5-9,13,34H,10-12,14-16H2,1-4H3,(H,29,30) GERYEJDQVFSXSN-UHFFFAOYSA-N 223894 US9328112, 116 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 890 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223894&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274381 336285574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390997 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1(C)C InChI=1S/C27H30FN5O2/c1-27(2)15-32(14-23(35)33-11-17(34)12-33)9-7-21(27)25-20-13-31(3)22-5-4-16(28)10-19(22)18-6-8-29-26(30-25)24(18)20/h4-8,10,17,34H,9,11-15H2,1-3H3,(H,29,30) ZYUCFKKZGIFVJJ-UHFFFAOYSA-N 223895 US9328112, 117 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 960 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223895&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274285 336285575 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390998 CN(C1CC(O)C1)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1 InChI=1S/C29H34FN5O2/c1-29(2)16-35(15-25(37)34(4)18-12-19(36)13-18)10-8-23(29)27-22-14-33(3)24-6-5-17(30)11-21(24)20-7-9-31-28(32-27)26(20)22/h5-9,11,18-19,36H,10,12-16H2,1-4H3,(H,31,32) YTUUFZGIOPZLQO-UHFFFAOYSA-N 223896 US9328112, 118 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1200 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223896&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274143 336285576 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 390999 CN(CC(O)CO)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1 223897 US9328112, 119 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1300 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223897&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274510 336285577 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391000 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(=O)N2CCC[C@H]2CO)C1 InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-12-18(28)6-7-23(21)31)8-9-29-27(25)30-26(22)17-4-2-10-32(13-17)15-24(35)33-11-3-5-19(33)16-34/h4,6-9,12,19,34H,2-3,5,10-11,13-16H2,1H3,(H,29,30)/t19-/m0/s1 IYCHUYFBYWHTHH-IBGZPJMESA-N 223898 US9328112, 120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 480 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223898&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274460 336285578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391001 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(=O)N2CC(O)C2)C1 InChI=1S/C25H26FN5O2/c1-29-13-20-23-18(19-9-16(26)4-5-21(19)29)6-7-27-25(23)28-24(20)15-3-2-8-30(10-15)14-22(33)31-11-17(32)12-31/h3-7,9,17,32H,2,8,10-14H2,1H3,(H,27,28) IHEXXFXOQWQKTN-UHFFFAOYSA-N 223899 US9328112, 121 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223899&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274095 336285579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391002 CN(C1CC(O)C1)C(=O)CN1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-10-17(28)5-6-23(21)31)7-8-29-27(25)30-26(22)16-4-3-9-33(13-16)15-24(35)32(2)18-11-19(34)12-18/h4-8,10,18-19,34H,3,9,11-15H2,1-2H3,(H,29,30) SVQWWGFAJUEGBA-UHFFFAOYSA-N 223900 US9328112, 122 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 420 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223900&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274243 336285580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391003 CN(CC(O)CO)C(=O)CN1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 223901 US9328112, 123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 540 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223901&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274263 336285581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391004 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 223902 US9328112, 124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223902&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274187 336285582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391005 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=C[C@@H]2COC(=O)N2CC1 InChI=1S/C22H18F2N4O2/c1-27-9-15-19-13(14-7-16(23)17(24)8-18(14)27)2-4-25-21(19)26-20(15)11-3-5-28-12(6-11)10-30-22(28)29/h2,4,6-8,12H,3,5,9-10H2,1H3,(H,25,26)/t12-/m1/s1 FGZHKQSWEGJXQZ-GFCCVEGCSA-N 223903 US9328112, 125 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223903&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274098 336285583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391006 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=C[C@H](CO)NCC1 InChI=1S/C21H20F2N4O/c1-27-9-15-19-13(14-7-16(22)17(23)8-18(14)27)3-5-25-21(19)26-20(15)11-2-4-24-12(6-11)10-28/h3,5-8,12,24,28H,2,4,9-10H2,1H3,(H,25,26)/t12-/m1/s1 VHLULLXOJUDLMG-GFCCVEGCSA-N 223904 US9328112, 126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223904&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274516 336285584 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391007 CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1 InChI=1S/C21H21FN4/c1-26-11-7-16-19-15(17-12-14(22)2-3-18(17)26)6-10-24-21(19)25-20(16)13-4-8-23-9-5-13/h2-4,6,10,12,23H,5,7-9,11H2,1H3,(H,24,25) DGLMWYAZWAVMAV-UHFFFAOYSA-N 223905 US9328112, 127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223905&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274154 336285585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391008 CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H23FN4O2S/c1-26-10-8-17-20-16(18-13-15(23)3-4-19(18)26)5-9-24-22(20)25-21(17)14-6-11-27(12-7-14)30(2,28)29/h3-6,9,13H,7-8,10-12H2,1-2H3,(H,24,25) BDILYQKHTUIRIQ-UHFFFAOYSA-N 223906 US9328112, 128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223906&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274509 336285586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391009 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)CCc1c23 InChI=1S/C25H28FN5O/c1-29(2)22(32)15-31-12-7-16(8-13-31)24-19-9-11-30(3)21-5-4-17(26)14-20(21)18-6-10-27-25(28-24)23(18)19/h4-7,10,14H,8-9,11-13,15H2,1-3H3,(H,27,28) OBEIMJZSRMOPFB-UHFFFAOYSA-N 223907 US9328112, 129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223907&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274332 336285587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391010 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 223908 US9328112, 130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223908&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274187 336285588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391011 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H20F2N4O2S/c1-26-11-15-19-13(14-9-16(22)17(23)10-18(14)26)3-6-24-21(19)25-20(15)12-4-7-27(8-5-12)30(2,28)29/h3-4,6,9-10H,5,7-8,11H2,1-2H3,(H,24,25) SFOFYNUMVBQVIQ-UHFFFAOYSA-N 223909 US9328112, 131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223909&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274339 336285589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391012 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23 InChI=1S/C24H25F2N5O/c1-29(2)21(32)13-31-8-5-14(6-9-31)23-17-12-30(3)20-11-19(26)18(25)10-16(20)15-4-7-27-24(28-23)22(15)17/h4-5,7,10-11H,6,8-9,12-13H2,1-3H3,(H,27,28) ATHQKQGBKACPPF-UHFFFAOYSA-N 223910 US9328112, 132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223910&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274355 336285590 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391013 COC(=O)CC1CC[C@@H](CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23 223911 US9328112, 133 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223911&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126961691 336285591 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391014 COC(=O)CC1CC[C@@H](CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23 223912 US9328112, 134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223912&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126961691 336285592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391015 CN1Cc2c([nH]c3nccc(-c4cccnc14)c23)C1=CCNCC1 InChI=1S/C19H19N5/c1-24-11-15-16-13(14-3-2-7-22-19(14)24)6-10-21-18(16)23-17(15)12-4-8-20-9-5-12/h2-4,6-7,10,20H,5,8-9,11H2,1H3,(H,21,23) HMTLBYNJVXRINY-UHFFFAOYSA-N 223913 US9328112, 135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223913&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274359 336285593 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391016 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 223914 US9328112, 136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223914&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274078 336285594 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391017 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H25F2N5O2/c1-30-12-18-23-16(17-8-19(26)20(27)9-21(17)30)2-5-28-25(23)29-24(18)14-3-6-31(7-4-14)13-22(34)32-10-15(33)11-32/h2-3,5,8-9,15,33H,4,6-7,10-13H2,1H3,(H,28,29) ZEEPXWQEKREJRP-UHFFFAOYSA-N 223915 US9328112, 137 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223915&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274325 336285595 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391018 CN1Cc2c([nH]c3nccc(-c4cccnc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H21N5O2S/c1-24-12-16-17-14(15-4-3-8-22-20(15)24)5-9-21-19(17)23-18(16)13-6-10-25(11-7-13)28(2,26)27/h3-6,8-9H,7,10-12H2,1-2H3,(H,21,23) GVZOMOLFKFQSGG-UHFFFAOYSA-N 223916 US9328112, 138 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223916&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274457 336285596 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391019 CNC(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cccnc4N(C)Cc1c23 InChI=1S/C21H22N6O/c1-22-21(28)27-10-6-13(7-11-27)18-16-12-26(2)20-15(4-3-8-24-20)14-5-9-23-19(25-18)17(14)16/h3-6,8-9H,7,10-12H2,1-2H3,(H,22,28)(H,23,25) OUQZWDMWFQRIRF-UHFFFAOYSA-N 223917 US9328112, 139 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223917&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274230 336285597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391020 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CC(CC(O)=O)C1 InChI=1S/C26H27FN4O2/c1-30-14-21-24-19(20-13-17(27)2-3-22(20)30)4-7-28-26(24)29-25(21)16-5-8-31(9-6-16)18-10-15(11-18)12-23(32)33/h2-5,7,13,15,18H,6,8-12,14H2,1H3,(H,28,29)(H,32,33) FDLYKPXPGUEBGI-UHFFFAOYSA-N 223918 US9328112, 140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223918&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274438 336285598 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391021 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 223919 US9328112, 141 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223919&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274426 336285599 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391022 CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1 InChI=1S/C22H23FN4/c1-3-17-20-19-15(16-12-14(23)4-5-18(16)27(17)2)8-11-25-22(19)26-21(20)13-6-9-24-10-7-13/h4-6,8,11-12,17,24H,3,7,9-10H2,1-2H3,(H,25,26)/t17-/m0/s1 WWCGHYOUUXBXGW-KRWDZBQOSA-N 223920 US9328112, 142 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223920&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274180 336285600 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391023 CC[C@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1 InChI=1S/C22H23FN4/c1-3-17-20-19-15(16-12-14(23)4-5-18(16)27(17)2)8-11-25-22(19)26-21(20)13-6-9-24-10-7-13/h4-6,8,11-12,17,24H,3,7,9-10H2,1-2H3,(H,25,26)/t17-/m1/s1 WWCGHYOUUXBXGW-QGZVFWFLSA-N 223921 US9328112, 143 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 417 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223921&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274137 336285601 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391024 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCNCC1 InChI=1S/C20H18F2N4/c1-26-10-14-18-12(13-8-15(21)16(22)9-17(13)26)4-7-24-20(18)25-19(14)11-2-5-23-6-3-11/h2,4,7-9,23H,3,5-6,10H2,1H3,(H,24,25) OSVIOYVYZCSILN-UHFFFAOYSA-N 223922 US9328112, 144 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223922&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274341 336285602 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391025 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H20F2N4O2/c1-27-10-15-20-13(14-8-16(23)17(24)9-18(14)27)2-5-25-22(20)26-21(15)12-3-6-28(7-4-12)11-19(29)30/h2-3,5,8-9H,4,6-7,10-11H2,1H3,(H,25,26)(H,29,30) OINXYQDCYRKLPR-UHFFFAOYSA-N 223923 US9328112, 145 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223923&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274272 336285603 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391026 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 223924 US9328112, 146 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223924&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274078 336285604 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391027 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H29F2N5O2/c1-32-13-20-25-18(19-11-21(28)22(29)12-23(19)32)4-7-30-27(25)31-26(20)16-5-9-33(10-6-16)14-24(36)34-8-2-3-17(34)15-35/h4-5,7,11-12,17,35H,2-3,6,8-10,13-15H2,1H3,(H,30,31)/t17-/m0/s1 QFJRVRBVNPFQTL-KRWDZBQOSA-N 223925 US9328112, 147 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223925&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274301 336285605 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391028 CN(C1CC(O)C1)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23 InChI=1S/C27H29F2N5O2/c1-32-13-20-25-18(19-11-21(28)22(29)12-23(19)32)3-6-30-27(25)31-26(20)15-4-7-34(8-5-15)14-24(36)33(2)16-9-17(35)10-16/h3-4,6,11-12,16-17,35H,5,7-10,13-14H2,1-2H3,(H,30,31) YCZIRHQPBQMEAP-UHFFFAOYSA-N 223926 US9328112, 148 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274251 336285606 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391029 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cccnc4N(C)Cc1c23 InChI=1S/C23H26N6O/c1-27(2)19(30)14-29-11-7-15(8-12-29)21-18-13-28(3)23-17(5-4-9-25-23)16-6-10-24-22(26-21)20(16)18/h4-7,9-10H,8,11-14H2,1-3H3,(H,24,26) DGVALAWYWFOEPE-UHFFFAOYSA-N 223927 US9328112, 149 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223927&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274476 336285607 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391030 CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 223928 US9328112, 150 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223928&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274435 336285608 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391031 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@@H]2COC(=O)N2CC1 InChI=1S/C22H19FN4O2/c1-26-10-17-19-15(16-9-13(23)2-3-18(16)26)4-6-24-21(19)25-20(17)12-5-7-27-14(8-12)11-29-22(27)28/h2-4,6,8-9,14H,5,7,10-11H2,1H3,(H,24,25)/t14-/m1/s1 SPYNLMODGQOGBH-CQSZACIVSA-N 223929 US9328112, 151 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223929&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274383 336285609 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391032 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2COC(=O)N2CC1 InChI=1S/C22H19FN4O2/c1-26-10-17-19-15(16-9-13(23)2-3-18(16)26)4-6-24-21(19)25-20(17)12-5-7-27-14(8-12)11-29-22(27)28/h2-4,6,8-9,14H,5,7,10-11H2,1H3,(H,24,25)/t14-/m0/s1 SPYNLMODGQOGBH-AWEZNQCLSA-N 223930 US9328112, 152 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223930&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274072 336285610 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391033 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN2[C@@H](COC2=O)C1 InChI=1S/C22H19FN4O2/c1-26-10-17-19-15(16-9-13(23)2-3-18(16)26)4-6-24-21(19)25-20(17)12-5-7-27-14(8-12)11-29-22(27)28/h2-6,9,14H,7-8,10-11H2,1H3,(H,24,25)/t14-/m1/s1 QRRJBCAOGRMKNV-CQSZACIVSA-N 223931 US9328112, 153 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274368 336285611 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391034 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H](CO)NCC1 InChI=1S/C21H21FN4O/c1-26-10-17-19-15(16-9-13(22)2-3-18(16)26)5-7-24-21(19)25-20(17)12-4-6-23-14(8-12)11-27/h2-3,5,7-9,14,23,27H,4,6,10-11H2,1H3,(H,24,25)/t14-/m1/s1 QGOGBUBLVRJFMI-CQSZACIVSA-N 223932 US9328112, 154 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223932&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274278 336285612 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391035 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@@H](CO)NCC1 InChI=1S/C21H21FN4O/c1-26-10-17-19-15(16-9-13(22)2-3-18(16)26)5-7-24-21(19)25-20(17)12-4-6-23-14(8-12)11-27/h2-3,5,7-9,14,23,27H,4,6,10-11H2,1H3,(H,24,25)/t14-/m0/s1 QGOGBUBLVRJFMI-AWEZNQCLSA-N 223933 US9328112, 155 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274480 336285613 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391036 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN[C@@H](CO)C1 InChI=1S/C21H21FN4O/c1-26-10-17-19-15(16-9-13(22)2-3-18(16)26)5-7-24-21(19)25-20(17)12-4-6-23-14(8-12)11-27/h2-5,7,9,14,23,27H,6,8,10-11H2,1H3,(H,24,25)/t14-/m1/s1 RAFHNNVNVIRIRR-CQSZACIVSA-N 223934 US9328112, 156 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274131 336285614 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391037 CN(CCO)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23 InChI=1S/C25H27F2N5O2/c1-30(9-10-33)22(34)14-32-7-4-15(5-8-32)24-18-13-31(2)21-12-20(27)19(26)11-17(21)16-3-6-28-25(29-24)23(16)18/h3-4,6,11-12,33H,5,7-10,13-14H2,1-2H3,(H,28,29) ODBVZJLXZZNHAG-UHFFFAOYSA-N 223935 US9328112, 157 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223935&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274297 336285615 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391038 CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCNCC1 InChI=1S/C20H20N4/c1-24-12-16-18-15(14-4-2-3-5-17(14)24)8-11-22-20(18)23-19(16)13-6-9-21-10-7-13/h2-6,8,11,21H,7,9-10,12H2,1H3,(H,22,23) BFXWBRURUCGEHI-UHFFFAOYSA-N 223936 US9328112, 158 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223936&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274114 336285616 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391039 CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCNCC1 InChI=1S/C20H19FN4/c1-25-11-14-18-17(13-4-2-3-5-16(13)25)15(21)10-23-20(18)24-19(14)12-6-8-22-9-7-12/h2-6,10,22H,7-9,11H2,1H3,(H,23,24) RCPVPRBBMXMZMR-UHFFFAOYSA-N 223937 US9328112, 159 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274389 336285617 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391040 CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22N4O2S/c1-24-13-17-19-16(15-5-3-4-6-18(15)24)7-10-22-21(19)23-20(17)14-8-11-25(12-9-14)28(2,26)27/h3-8,10H,9,11-13H2,1-2H3,(H,22,23) MMEUSVCQHRYTGH-UHFFFAOYSA-N 223938 US9328112, 160 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274320 336285618 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391041 CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H21FN4O2S/c1-25-12-15-19-18(14-5-3-4-6-17(14)25)16(22)11-23-21(19)24-20(15)13-7-9-26(10-8-13)29(2,27)28/h3-7,11H,8-10,12H2,1-2H3,(H,23,24) NIBMHEAVUJBBHW-UHFFFAOYSA-N 223939 US9328112, 161 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223939&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274294 336285619 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391042 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4ccccc4N(C)Cc1c23 InChI=1S/C24H27N5O/c1-27(2)21(30)15-29-12-9-16(10-13-29)23-19-14-28(3)20-7-5-4-6-17(20)18-8-11-25-24(26-23)22(18)19/h4-9,11H,10,12-15H2,1-3H3,(H,25,26) UEQXAOJBANULAT-UHFFFAOYSA-N 223940 US9328112, 162 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 115 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274248 336285620 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391043 CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4ccccc4N(C)Cc1c23 InChI=1S/C24H26FN5O/c1-28(2)20(31)14-30-10-8-15(9-11-30)23-17-13-29(3)19-7-5-4-6-16(19)21-18(25)12-26-24(27-23)22(17)21/h4-8,12H,9-11,13-14H2,1-3H3,(H,26,27) QAENZXDWLJDJAN-UHFFFAOYSA-N 223941 US9328112, 163 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223941&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274336 336285621 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391044 OCC(O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4OCc1c23 223942 US9328112, 164 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223942&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274126 336285622 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391045 OC(=O)CC1CCC(CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4OCc1c23 InChI=1S/C27H28FN3O3/c28-18-3-6-23-21(14-18)20-7-10-29-27-25(20)22(15-34-23)26(30-27)17-8-11-31(12-9-17)19-4-1-16(2-5-19)13-24(32)33/h3,6-8,10,14,16,19H,1-2,4-5,9,11-13,15H2,(H,29,30)(H,32,33) WNVJQAVRHBYKSI-UHFFFAOYSA-N 223943 US9328112, 165 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 390 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223943&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274413 336285623 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391046 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 223944 US9328112, 166 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223944&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274127 336285624 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391047 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 223945 US9328112, 167 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274178 336285625 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391048 CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C26H30FN5O/c1-5-20-24-23-18(19-14-17(27)6-7-21(19)31(20)4)8-11-28-26(23)29-25(24)16-9-12-32(13-10-16)15-22(33)30(2)3/h6-9,11,14,20H,5,10,12-13,15H2,1-4H3,(H,28,29)/t20-/m0/s1 IFIVPAMSRSNWQL-FQEVSTJZSA-N 223946 US9328112, 168 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274092 336285626 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391049 CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 223947 US9328112, 169 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223947&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274159 336285627 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391050 CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 223948 US9328112, 170 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274159 336285628 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391051 CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 223949 US9328112, 171 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223949&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274094 336285629 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391052 CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)C1CCC(CC1)C(O)=O InChI=1S/C27H30N4O2/c1-30-16-22-24-21(20-4-2-3-5-23(20)30)10-13-28-26(24)29-25(22)17-11-14-31(15-12-17)19-8-6-18(7-9-19)27(32)33/h2-5,10-11,13,18-19H,6-9,12,14-16H2,1H3,(H,28,29)(H,32,33) HKHSLKKZKCVNJT-UHFFFAOYSA-N 223950 US9328112, 172 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274094 336285630 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391053 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=CC#N InChI=1S/C28H28FN5/c1-33-17-24-26-22(23-16-20(29)4-7-25(23)33)9-13-31-28(26)32-27(24)19-10-14-34(15-11-19)21-5-2-18(3-6-21)8-12-30/h4,7-10,13,16,21H,2-3,5-6,11,14-15,17H2,1H3,(H,31,32)/b18-8- WZMWZPOQBRNKPT-LSCVHKIXSA-N 223951 US9328112, 173 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223951&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274352 336285631 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391054 COC(=O)C(C)=C1CCC(CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C30H33FN4O2/c1-18(30(36)37-3)19-4-7-22(8-5-19)35-14-11-20(12-15-35)28-25-17-34(2)26-9-6-21(31)16-24(26)23-10-13-32-29(33-28)27(23)25/h6,9-11,13,16,22H,4-5,7-8,12,14-15,17H2,1-3H3,(H,32,33)/b19-18- VSWKFLPTFGDKFF-HNENSFHCSA-N 223952 US9328112, 174 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223952&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274194 336285632 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391055 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=CC(=O)OC(C)(C)C InChI=1S/C32H37FN4O2/c1-32(2,3)39-28(38)17-20-5-8-23(9-6-20)37-15-12-21(13-16-37)30-26-19-36(4)27-10-7-22(33)18-25(27)24-11-14-34-31(35-30)29(24)26/h7,10-12,14,17-18,23H,5-6,8-9,13,15-16,19H2,1-4H3,(H,34,35)/b20-17- IYKRFQVMTKKRBS-JZJYNLBNSA-N 223953 US9328112, 175 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126961692 336285633 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391056 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=C(C)C(O)=O InChI=1S/C29H31FN4O2/c1-17(29(35)36)18-3-6-21(7-4-18)34-13-10-19(11-14-34)27-24-16-33(2)25-8-5-20(30)15-23(25)22-9-12-31-28(32-27)26(22)24/h5,8-10,12,15,21H,3-4,6-7,11,13-14,16H2,1-2H3,(H,31,32)(H,35,36)/b18-17- OUYJSIAHIZDJFA-ZCXUNETKSA-N 223954 US9328112, 176 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223954&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274421 336285634 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391057 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=CC(O)=O InChI=1S/C28H29FN4O2/c1-32-16-23-26-21(22-15-19(29)4-7-24(22)32)8-11-30-28(26)31-27(23)18-9-12-33(13-10-18)20-5-2-17(3-6-20)14-25(34)35/h4,7-9,11,14-15,20H,2-3,5-6,10,12-13,16H2,1H3,(H,30,31)(H,34,35)/b17-14- REGBBCCGQBESPN-VKAVYKQESA-N 223955 US9328112, 177 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223955&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274193 336285635 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391058 CN(C)S(=O)(=O)CCN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23 InChI=1S/C24H28FN5O2S/c1-28(2)33(31,32)13-12-30-10-7-16(8-11-30)23-20-15-29(3)21-5-4-17(25)14-19(21)18-6-9-26-24(27-23)22(18)20/h4-7,9,14H,8,10-13,15H2,1-3H3,(H,26,27) KDEVBAKASDVLRI-UHFFFAOYSA-N 223956 US9328112, 178 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223956&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274444 336285636 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391059 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CCS(N)(=O)=O)CC1 InChI=1S/C22H24FN5O2S/c1-27-13-18-20-16(17-12-15(23)2-3-19(17)27)4-7-25-22(20)26-21(18)14-5-8-28(9-6-14)10-11-31(24,29)30/h2-5,7,12H,6,8-11,13H2,1H3,(H,25,26)(H2,24,29,30) ZEILJXXEIJVQDO-UHFFFAOYSA-N 223957 US9328112, 179 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274234 336285637 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391060 CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 223958 US9328112, 180 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223958&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274323 336285638 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391061 CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 223959 US9328112, 181 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223959&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274156 336285639 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391062 CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 223960 US9328112, 182 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223960&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274323 336285640 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391063 CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC1)C(O)=O 223961 US9328112, 183 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223961&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274156 336285641 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391064 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC1)C1CCC(CC1)=CC(O)=O InChI=1S/C29H31FN4O2/c1-33-17-24-27-22(23-16-20(30)6-9-25(23)33)10-12-31-29(27)32-28(24)19-3-2-13-34(14-11-19)21-7-4-18(5-8-21)15-26(35)36/h3,6,9-10,12,15-16,21H,2,4-5,7-8,11,13-14,17H2,1H3,(H,31,32)(H,35,36)/b18-15- HGHNAWUSPUQKMV-SDXDJHTJSA-N 223962 US9328112, 184 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274286 336285642 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391065 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)C(C)(C)C(O)=O InChI=1S/C30H35FN4O2/c1-30(2,29(36)37)19-4-7-21(8-5-19)35-14-11-18(12-15-35)27-24-17-34(3)25-9-6-20(31)16-23(25)22-10-13-32-28(33-27)26(22)24/h6,9-11,13,16,19,21H,4-5,7-8,12,14-15,17H2,1-3H3,(H,32,33)(H,36,37) QKKVPRHBIYOEKS-UHFFFAOYSA-N 223963 US9328112, 185 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223963&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274399 336285643 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391066 CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)[C@H]1C[C@H](C1)C(=O)OC InChI=1S/C28H31FN4O2/c1-4-22-25-24-20(21-15-18(29)5-6-23(21)32(22)2)7-10-30-27(24)31-26(25)16-8-11-33(12-9-16)19-13-17(14-19)28(34)35-3/h5-8,10,15,17,19,22H,4,9,11-14H2,1-3H3,(H,30,31)/t17-,19+,22-/m0/s1 ZQGBXFHFXRBZAS-KPLVRAHFSA-N 223964 US9328112, 186 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223964&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274482 336285644 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391067 CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)[C@H]1C[C@H](C1)C(O)=O InChI=1S/C27H29FN4O2/c1-3-21-24-23-19(20-14-17(28)4-5-22(20)31(21)2)6-9-29-26(23)30-25(24)15-7-10-32(11-8-15)18-12-16(13-18)27(33)34/h4-7,9,14,16,18,21H,3,8,10-13H2,1-2H3,(H,29,30)(H,33,34)/t16-,18+,21-/m0/s1 CAFRPEXZJRPMMG-CDXJDZJCSA-N 223965 US9328112, 187 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223965&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274218 336285645 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391068 CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1C[C@H](C1)C(O)=O 223966 US9328112, 188 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223966&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274133 336285646 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391069 CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)[C@H]1C[C@@H](C1)C(O)=O InChI=1S/C27H29FN4O2/c1-3-21-24-23-19(20-14-17(28)4-5-22(20)31(21)2)6-9-29-26(23)30-25(24)15-7-10-32(11-8-15)18-12-16(13-18)27(33)34/h4-7,9,14,16,18,21H,3,8,10-13H2,1-2H3,(H,29,30)(H,33,34)/t16-,18-,21-/m0/s1 CAFRPEXZJRPMMG-MDKPJZGXSA-N 223967 US9328112, 189 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223967&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274218 336285647 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391070 CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1C[C@@H](C1)C(O)=O 223968 US9328112, 190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223968&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274133 336285648 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391071 CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)C(C#N)C(O)=O 223969 US9328112, 191 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223969&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 121297559 336285649 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391072 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CC(CC(O)=O)C1 InChI=1S/C26H26F2N4O2/c1-31-13-19-24-23(18-11-16(27)2-3-21(18)31)20(28)12-29-26(24)30-25(19)15-4-6-32(7-5-15)17-8-14(9-17)10-22(33)34/h2-4,11-12,14,17H,5-10,13H2,1H3,(H,29,30)(H,33,34) SLZZIVJLQCGOMW-UHFFFAOYSA-N 223970 US9328112, 192 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223970&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274208 336285650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 391073 CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CC(C1)C(O)=O InChI=1S/C25H24F2N4O2/c1-30-12-18-22-21(17-10-15(26)2-3-20(17)30)19(27)11-28-24(22)29-23(18)13-4-6-31(7-5-13)16-8-14(9-16)25(32)33/h2-4,10-11,14,16H,5-9,12H2,1H3,(H,28,29)(H,32,33) QWJHTTIJLJKUFW-UHFFFAOYSA-N 223971 US9328112, 193 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76 US Patent 10.7270/Q2JQ0ZVM aid1802681 US9328112 Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223971&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274427 336285651 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451189 COc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5O2S/c1-30-15-6-12(10-31(2,29)26-11-24)5-14(8-15)27-20-25-9-18(23)19(28-20)16-4-3-13(21)7-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28) QCRVQKOHWOFULW-UHFFFAOYSA-N 258868 US9499492, 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258868&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763284 350083570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451190 COc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4O2S/c1-28-14-6-11(10-29(2,23)27)5-13(8-14)25-19-24-9-17(22)18(26-19)15-4-3-12(20)7-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26) WEDFKUDJAKFPOA-UHFFFAOYSA-N 258869 US9499492, 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1180 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258869&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763285 350083571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451191 COCCS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C22H17F6N5O2S/c1-35-4-5-36(34,31-12-29)11-13-6-14(22(26,27)28)8-16(7-13)32-21-30-10-19(25)20(33-21)17-3-2-15(23)9-18(17)24/h2-3,6-10H,4-5,11H2,1H3,(H,30,32,33) YZIVCUAFHHWEHX-UHFFFAOYSA-N 258870 US9499492, 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258870&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763286 350083572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451192 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30)/t34-/m1/s1 QQOSANNDIZSJOV-UUWRZZSWSA-N 258871 US9499492, 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258871&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953955 350083573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451193 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30)/t34-/m0/s1 QQOSANNDIZSJOV-UMSFTDKQSA-N 258872 US9499492, 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 199 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258872&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953956 350083574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451194 NCCS(=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31) XRRZOHQRDSHRLR-UHFFFAOYSA-N 258873 US9499492, 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 417 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258873&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763287 350083575 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451195 NCC[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31)/t33-/m1/s1 XRRZOHQRDSHRLR-MGBGTMOVSA-N 258874 US9499492, 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 278 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258874&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953957 350083576 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451196 NCC[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31)/t33-/m0/s1 XRRZOHQRDSHRLR-XIFFEERXSA-N 258875 US9499492, 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 276 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258875&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953958 350083577 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451197 CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32) ASMMFFMWZUTPQZ-UHFFFAOYSA-N 258876 US9499492, 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258876&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763288 350083578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451198 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32)/t34-/m1/s1 ASMMFFMWZUTPQZ-UUWRZZSWSA-N 258877 US9499492, 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258877&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953959 350083579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451199 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32)/t34-/m0/s1 ASMMFFMWZUTPQZ-UMSFTDKQSA-N 258878 US9499492, 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953960 350083580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451200 C[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F InChI=1S/C18H14F8N4OS2/c1-32(27,31)9-10-4-12(7-13(5-10)33(22,23,24,25)26)29-18-28-8-16(21)17(30-18)14-3-2-11(19)6-15(14)20/h2-8,27H,9H2,1H3,(H,28,29,30)/t32-/m1/s1 LCUQLPMTQFAZGB-JGCGQSQUSA-N 258879 US9499492, 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258879&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953961 350083581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451201 C[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F InChI=1S/C18H14F8N4OS2/c1-32(27,31)9-10-4-12(7-13(5-10)33(22,23,24,25)26)29-18-28-8-16(21)17(30-18)14-3-2-11(19)6-15(14)20/h2-8,27H,9H2,1H3,(H,28,29,30)/t32-/m0/s1 LCUQLPMTQFAZGB-YTTGMZPUSA-N 258880 US9499492, 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258880&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953962 350083582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451202 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC(N)=O InChI=1S/C19H15F8N5O2S2/c1-35(34,32-18(28)33)9-10-4-12(7-13(5-10)36(23,24,25,26)27)30-19-29-8-16(22)17(31-19)14-3-2-11(20)6-15(14)21/h2-8H,9H2,1H3,(H2,28,33)(H,29,30,31)/t35-/m1/s1 YDZHKGRMQSRNSO-PGUFJCEWSA-N 258881 US9499492, 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258881&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953963 350083583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451203 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC(N)=O InChI=1S/C19H15F8N5O2S2/c1-35(34,32-18(28)33)9-10-4-12(7-13(5-10)36(23,24,25,26)27)30-19-29-8-16(22)17(31-19)14-3-2-11(20)6-15(14)21/h2-8H,9H2,1H3,(H2,28,33)(H,29,30,31)/t35-/m0/s1 YDZHKGRMQSRNSO-DHUJRADRSA-N 258882 US9499492, 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258882&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953964 350083584 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451204 Cc1cc(C[S@@](C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28)/t30-/m1/s1 BYXYXBYJIWSQPF-SSEXGKCCSA-N 258883 US9499492, 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953965 350083585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451205 Cc1cc(C[S@](C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28)/t30-/m0/s1 BYXYXBYJIWSQPF-PMERELPUSA-N 258884 US9499492, 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 177 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258884&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953966 350083586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451206 Cc1cc(C[S@](C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26)/t28-/m1/s1 OQCNZWDOWASPKR-MUUNZHRXSA-N 258885 US9499492, 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6310 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953967 350083587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451207 Cc1cc(C[S@@](C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26)/t28-/m0/s1 OQCNZWDOWASPKR-NDEPHWFRSA-N 258886 US9499492, 38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6490 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258886&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953968 350083588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451208 C[S@@](=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28)/t30-/m1/s1 OBGYQQHPNRVDPR-SSEXGKCCSA-N 258887 US9499492, 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 177 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258887&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953969 350083589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451209 C[S@](=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m0/s1 UENWNKFTXVFLIA-NDEPHWFRSA-N 258890 US9499492, 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 334 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258890&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953972 350083592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451090 CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31) PAJDWWDQYJRLJW-UHFFFAOYSA-N 258849 US9499492, 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258849&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763136 350083551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451091 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31)/t33-/m1/s1 PAJDWWDQYJRLJW-MGBGTMOVSA-N 258850 US9499492, 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258850&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953949 350083552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451092 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31)/t33-/m0/s1 PAJDWWDQYJRLJW-XIFFEERXSA-N 258851 US9499492, 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258851&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953950 350083553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451093 CS(=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29) QDGSSDGVRXTZAY-UHFFFAOYSA-N 258852 US9499492, 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258852&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763137 350083554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451094 C[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29)/t31-/m1/s1 QDGSSDGVRXTZAY-WJOKGBTCSA-N 258853 US9499492, 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258853&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953951 350083555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451095 C[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29)/t31-/m0/s1 QDGSSDGVRXTZAY-HKBQPEDESA-N 258854 US9499492, 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258854&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953952 350083556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451096 CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30) QQOSANNDIZSJOV-UHFFFAOYSA-N 258855 US9499492, 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763138 350083557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451097 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C21H19F3N4O3S/c1-3-31-21(29)28-32(2,30)12-13-5-4-6-15(9-13)26-20-25-11-18(24)19(27-20)16-8-7-14(22)10-17(16)23/h4-11H,3,12H2,1-2H3,(H,25,26,27) GSYOSLIIPNEGLU-UHFFFAOYSA-N 258856 US9499492, 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258856&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763139 350083558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451098 CS(=N)(=O)Cc1cccc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H15F3N4OS/c1-27(22,26)10-11-3-2-4-13(7-11)24-18-23-9-16(21)17(25-18)14-6-5-12(19)8-15(14)20/h2-9,22H,10H2,1H3,(H,23,24,25) OHNUPWWJZVPTRI-UHFFFAOYSA-N 258857 US9499492, 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258857&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90162278 350083559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451099 CS(=O)(Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13F4N5OS/c1-30(29,26-10-24)9-11-4-13(21)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-12(20)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) OWNYBBZDYVOTGP-UHFFFAOYSA-N 258858 US9499492, 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258858&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763140 350083560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451100 CS(=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) MGQXIWWRDBVRRC-UHFFFAOYSA-N 258859 US9499492, 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258859&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763141 350083561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451101 C[S@@](=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m1/s1 MGQXIWWRDBVRRC-MUUNZHRXSA-N 258860 US9499492, 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258860&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953953 350083562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451102 C[S@](=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m0/s1 MGQXIWWRDBVRRC-NDEPHWFRSA-N 258861 US9499492, 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258861&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953954 350083563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451103 CS(=O)(Cc1cc(Cl)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13ClF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) KXKPSUYNHGDABY-UHFFFAOYSA-N 258862 US9499492, 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258862&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763207 350083564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451104 CS(=N)(=O)Cc1cc(Cl)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14ClF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) PAVKBRNWXJZQJZ-UHFFFAOYSA-N 258863 US9499492, 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258863&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763208 350083565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451105 Cc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28) BYXYXBYJIWSQPF-UHFFFAOYSA-N 258864 US9499492, 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258864&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763209 350083566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451106 Cc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26) OQCNZWDOWASPKR-UHFFFAOYSA-N 258865 US9499492, 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258865&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763210 350083567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451107 CS(=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) OBGYQQHPNRVDPR-UHFFFAOYSA-N 258866 US9499492, 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258866&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763211 350083568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451108 CS(=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) UENWNKFTXVFLIA-UHFFFAOYSA-N 258867 US9499492, 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258867&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763212 350083569 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451109 COc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5O2S/c1-30-15-6-12(10-31(2,29)26-11-24)5-14(8-15)27-20-25-9-18(23)19(28-20)16-4-3-13(21)7-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28) QCRVQKOHWOFULW-UHFFFAOYSA-N 258868 US9499492, 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258868&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763284 350083570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451110 COc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4O2S/c1-28-14-6-11(10-29(2,23)27)5-13(8-14)25-19-24-9-17(22)18(26-19)15-4-3-12(20)7-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26) WEDFKUDJAKFPOA-UHFFFAOYSA-N 258869 US9499492, 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258869&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763285 350083571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451111 COCCS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C22H17F6N5O2S/c1-35-4-5-36(34,31-12-29)11-13-6-14(22(26,27)28)8-16(7-13)32-21-30-10-19(25)20(33-21)17-3-2-15(23)9-18(17)24/h2-3,6-10H,4-5,11H2,1H3,(H,30,32,33) YZIVCUAFHHWEHX-UHFFFAOYSA-N 258870 US9499492, 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258870&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763286 350083572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451112 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30)/t34-/m1/s1 QQOSANNDIZSJOV-UUWRZZSWSA-N 258871 US9499492, 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258871&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953955 350083573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451113 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30)/t34-/m0/s1 QQOSANNDIZSJOV-UMSFTDKQSA-N 258872 US9499492, 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258872&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953956 350083574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451114 NCCS(=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31) XRRZOHQRDSHRLR-UHFFFAOYSA-N 258873 US9499492, 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258873&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763287 350083575 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451115 CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32) ASMMFFMWZUTPQZ-UHFFFAOYSA-N 258876 US9499492, 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258876&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763288 350083578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451116 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32)/t34-/m1/s1 ASMMFFMWZUTPQZ-UUWRZZSWSA-N 258877 US9499492, 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258877&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953959 350083579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451117 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32)/t34-/m0/s1 ASMMFFMWZUTPQZ-UMSFTDKQSA-N 258878 US9499492, 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953960 350083580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451118 C[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F InChI=1S/C18H14F8N4OS2/c1-32(27,31)9-10-4-12(7-13(5-10)33(22,23,24,25)26)29-18-28-8-16(21)17(30-18)14-3-2-11(19)6-15(14)20/h2-8,27H,9H2,1H3,(H,28,29,30)/t32-/m1/s1 LCUQLPMTQFAZGB-JGCGQSQUSA-N 258879 US9499492, 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258879&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953961 350083581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451119 C[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F InChI=1S/C18H14F8N4OS2/c1-32(27,31)9-10-4-12(7-13(5-10)33(22,23,24,25)26)29-18-28-8-16(21)17(30-18)14-3-2-11(19)6-15(14)20/h2-8,27H,9H2,1H3,(H,28,29,30)/t32-/m0/s1 LCUQLPMTQFAZGB-YTTGMZPUSA-N 258880 US9499492, 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258880&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953962 350083582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451120 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC(N)=O InChI=1S/C19H15F8N5O2S2/c1-35(34,32-18(28)33)9-10-4-12(7-13(5-10)36(23,24,25,26)27)30-19-29-8-16(22)17(31-19)14-3-2-11(20)6-15(14)21/h2-8H,9H2,1H3,(H2,28,33)(H,29,30,31)/t35-/m1/s1 YDZHKGRMQSRNSO-PGUFJCEWSA-N 258881 US9499492, 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258881&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953963 350083583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451121 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC(N)=O InChI=1S/C19H15F8N5O2S2/c1-35(34,32-18(28)33)9-10-4-12(7-13(5-10)36(23,24,25,26)27)30-19-29-8-16(22)17(31-19)14-3-2-11(20)6-15(14)21/h2-8H,9H2,1H3,(H2,28,33)(H,29,30,31)/t35-/m0/s1 YDZHKGRMQSRNSO-DHUJRADRSA-N 258882 US9499492, 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258882&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953964 350083584 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451122 Cc1cc(C[S@@](C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28)/t30-/m1/s1 BYXYXBYJIWSQPF-SSEXGKCCSA-N 258883 US9499492, 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953965 350083585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451123 Cc1cc(C[S@](C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28)/t30-/m0/s1 BYXYXBYJIWSQPF-PMERELPUSA-N 258884 US9499492, 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258884&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953966 350083586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451124 Cc1cc(C[S@](C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26)/t28-/m1/s1 OQCNZWDOWASPKR-MUUNZHRXSA-N 258885 US9499492, 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953967 350083587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451125 Cc1cc(C[S@@](C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26)/t28-/m0/s1 OQCNZWDOWASPKR-NDEPHWFRSA-N 258886 US9499492, 38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258886&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953968 350083588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451126 C[S@@](=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28)/t30-/m1/s1 OBGYQQHPNRVDPR-SSEXGKCCSA-N 258887 US9499492, 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258887&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953969 350083589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451127 C[S@](=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28)/t30-/m0/s1 OBGYQQHPNRVDPR-PMERELPUSA-N 258888 US9499492, 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258888&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953970 350083590 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451128 C[S@@](=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m1/s1 UENWNKFTXVFLIA-MUUNZHRXSA-N 258889 US9499492, 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258889&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953971 350083591 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451129 C[S@](=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m0/s1 UENWNKFTXVFLIA-NDEPHWFRSA-N 258890 US9499492, 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803640 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258890&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953972 350083592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451171 CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31) PAJDWWDQYJRLJW-UHFFFAOYSA-N 258849 US9499492, 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258849&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763136 350083551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451172 C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31)/t33-/m1/s1 PAJDWWDQYJRLJW-MGBGTMOVSA-N 258850 US9499492, 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258850&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953949 350083552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451173 C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31)/t33-/m0/s1 PAJDWWDQYJRLJW-XIFFEERXSA-N 258851 US9499492, 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258851&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953950 350083553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451174 CS(=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29) QDGSSDGVRXTZAY-UHFFFAOYSA-N 258852 US9499492, 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 251 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258852&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763137 350083554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451175 C[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29)/t31-/m1/s1 QDGSSDGVRXTZAY-WJOKGBTCSA-N 258853 US9499492, 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 235 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258853&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953951 350083555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451176 C[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29)/t31-/m0/s1 QDGSSDGVRXTZAY-HKBQPEDESA-N 258854 US9499492, 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 231 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258854&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953952 350083556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451177 CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30) QQOSANNDIZSJOV-UHFFFAOYSA-N 258855 US9499492, 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 105 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763138 350083557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451178 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C21H19F3N4O3S/c1-3-31-21(29)28-32(2,30)12-13-5-4-6-15(9-13)26-20-25-11-18(24)19(27-20)16-8-7-14(22)10-17(16)23/h4-11H,3,12H2,1-2H3,(H,25,26,27) GSYOSLIIPNEGLU-UHFFFAOYSA-N 258856 US9499492, 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258856&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763139 350083558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451179 CS(=N)(=O)Cc1cccc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H15F3N4OS/c1-27(22,26)10-11-3-2-4-13(7-11)24-18-23-9-16(21)17(25-18)14-6-5-12(19)8-15(14)20/h2-9,22H,10H2,1H3,(H,23,24,25) OHNUPWWJZVPTRI-UHFFFAOYSA-N 258857 US9499492, 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2710 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258857&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90162278 350083559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451180 CS(=O)(Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13F4N5OS/c1-30(29,26-10-24)9-11-4-13(21)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-12(20)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) OWNYBBZDYVOTGP-UHFFFAOYSA-N 258858 US9499492, 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 289 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258858&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763140 350083560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451181 CS(=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) MGQXIWWRDBVRRC-UHFFFAOYSA-N 258859 US9499492, 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 979 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258859&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763141 350083561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451182 C[S@@](=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m1/s1 MGQXIWWRDBVRRC-MUUNZHRXSA-N 258860 US9499492, 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1090 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258860&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953953 350083562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451183 C[S@](=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m0/s1 MGQXIWWRDBVRRC-NDEPHWFRSA-N 258861 US9499492, 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1160 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258861&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131953954 350083563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451184 CS(=O)(Cc1cc(Cl)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13ClF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) KXKPSUYNHGDABY-UHFFFAOYSA-N 258862 US9499492, 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 272 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258862&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763207 350083564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451185 CS(=N)(=O)Cc1cc(Cl)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C18H14ClF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) PAVKBRNWXJZQJZ-UHFFFAOYSA-N 258863 US9499492, 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 892 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258863&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763208 350083565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451186 Cc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28) BYXYXBYJIWSQPF-UHFFFAOYSA-N 258864 US9499492, 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 165 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258864&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763209 350083566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451187 Cc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26) OQCNZWDOWASPKR-UHFFFAOYSA-N 258865 US9499492, 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 470 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258865&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763210 350083567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 451188 CS(=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) OBGYQQHPNRVDPR-UHFFFAOYSA-N 258866 US9499492, 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 175 8 22.00 C US Patent 10.7270/Q2GH9GW0 aid1803642 US9499492 Lucking, U; Kosemund, D; Bohlmann, R; Scholz, A; Lienau, P; Siemeister, G; Bomer, U Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258866&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74763211 350083568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094723 CCOP(=O)(Cc1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1)OCC InChI=1S/C21H23N4O5P/c1-3-29-31(28,30-4-2)14-16-8-10-18(11-9-16)24-21-13-20(22-15-23-21)17-6-5-7-19(12-17)25(26)27/h5-13,15H,3-4,14H2,1-2H3,(H,22,23,24) WDRXORCBTBXQBX-UHFFFAOYSA-N 50013431 CHEMBL3264101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013431&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579974 242058237 CHEMBL3264101 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094724 CCOP(=O)(OCC)C(O)c1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C21H23N4O6P/c1-3-30-32(29,31-4-2)21(26)15-8-10-17(11-9-15)24-20-13-19(22-14-23-20)16-6-5-7-18(12-16)25(27)28/h5-14,21,26H,3-4H2,1-2H3,(H,22,23,24) OLYMWKPKZVDPCV-UHFFFAOYSA-N 50013432 CHEMBL3264102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4577 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013432&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579975 242058238 CHEMBL3264102 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094725 CCOP(=O)(Cc1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1)OCC InChI=1S/C21H25N4O3P/c1-3-27-29(26,28-4-2)14-16-8-10-19(11-9-16)25-21-13-20(23-15-24-21)17-6-5-7-18(22)12-17/h5-13,15H,3-4,14,22H2,1-2H3,(H,23,24,25) DZFVHIRRFAADID-UHFFFAOYSA-N 50013433 CHEMBL3264103 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3110 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013433&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580012 242058239 CHEMBL3264103 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094726 CCOP(=O)(Cc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C)OCC InChI=1S/C23H28N3O4P/c1-5-29-31(27,30-6-2)15-18-13-19(12-11-17(18)3)26-23-14-21(24-16-25-23)20-9-7-8-10-22(20)28-4/h7-14,16H,5-6,15H2,1-4H3,(H,24,25,26) OUSKEGTXGKODAX-UHFFFAOYSA-N 50013434 CHEMBL3264104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5220 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013434&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580013 242058240 CHEMBL3264104 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094727 OP(O)(=O)Cc1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C17H15N4O5P/c22-21(23)15-3-1-2-13(8-15)16-9-17(19-11-18-16)20-14-6-4-12(5-7-14)10-27(24,25)26/h1-9,11H,10H2,(H,18,19,20)(H2,24,25,26) IODPOLOMIWXHEG-UHFFFAOYSA-N 50013435 CHEMBL3264105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2100 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013435&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90656363 242058241 CHEMBL3264105 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094728 Nc1cccc(c1)-c1cc(Nc2ccc(CP(O)(O)=O)cc2)ncn1 InChI=1S/C17H17N4O3P/c18-14-3-1-2-13(8-14)16-9-17(20-11-19-16)21-15-6-4-12(5-7-15)10-25(22,23)24/h1-9,11H,10,18H2,(H,19,20,21)(H2,22,23,24) MNFCFKSJBMLEFA-UHFFFAOYSA-N 50013436 CHEMBL3264106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1130 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013436&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90656364 242058242 CHEMBL3264106 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094729 CCOP(=O)(CC)Cc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1 InChI=1S/C22H26N3O3P/c1-4-28-29(26,5-2)15-17-9-8-10-18(13-17)25-22-14-20(23-16-24-22)19-11-6-7-12-21(19)27-3/h6-14,16H,4-5,15H2,1-3H3,(H,23,24,25) GYMVAYZPQOPYJH-UHFFFAOYSA-N 50013437 CHEMBL3264107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 197 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013437&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580016 242058243 CHEMBL3264107 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094730 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1)OCC InChI=1S/C23H28N3O3P/c1-4-13-30(27,29-5-2)16-18-9-8-10-19(14-18)26-23-15-21(24-17-25-23)20-11-6-7-12-22(20)28-3/h6-12,14-15,17H,4-5,13,16H2,1-3H3,(H,24,25,26) GSAVDTFDQZGCCB-UHFFFAOYSA-N 50013438 CHEMBL3264108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 296 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013438&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580017 242058244 CHEMBL3264108 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094731 CCOP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1)c1ccccc1 InChI=1S/C26H26N3O3P/c1-3-32-33(30,22-12-5-4-6-13-22)18-20-10-9-11-21(16-20)29-26-17-24(27-19-28-26)23-14-7-8-15-25(23)31-2/h4-17,19H,3,18H2,1-2H3,(H,27,28,29) AFBSODUBMZBGMD-UHFFFAOYSA-N 50013439 CHEMBL3264109 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 517 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013439&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580040 242058245 CHEMBL3264109 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094732 CCOP(=O)(CC)Cc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C21H23N4O4P/c1-3-29-30(28,4-2)14-16-7-5-9-18(11-16)24-21-13-20(22-15-23-21)17-8-6-10-19(12-17)25(26)27/h5-13,15H,3-4,14H2,1-2H3,(H,22,23,24) UPTQCGHREDOBNJ-UHFFFAOYSA-N 50013440 CHEMBL3264110 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6432 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013440&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580041 242058246 CHEMBL3264110 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094733 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1)OCC InChI=1S/C22H25N4O4P/c1-3-11-31(29,30-4-2)15-17-7-5-9-19(12-17)25-22-14-21(23-16-24-22)18-8-6-10-20(13-18)26(27)28/h5-10,12-14,16H,3-4,11,15H2,1-2H3,(H,23,24,25) VNGPVPAVQLKJGA-UHFFFAOYSA-N 50013441 CHEMBL3264111 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8056 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013441&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580042 242058247 CHEMBL3264111 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094734 CCOP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1)c1ccccc1 InChI=1S/C25H23N4O4P/c1-2-33-34(32,23-12-4-3-5-13-23)17-19-8-6-10-21(14-19)28-25-16-24(26-18-27-25)20-9-7-11-22(15-20)29(30)31/h3-16,18H,2,17H2,1H3,(H,26,27,28) JTAWGELRNFFWCF-UHFFFAOYSA-N 50013442 CHEMBL3264112 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013442&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580043 242058248 CHEMBL3264112 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094735 CCOP(=O)(CC)Cc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1 InChI=1S/C21H25N4O2P/c1-3-27-28(26,4-2)14-16-7-5-10-19(11-16)25-21-13-20(23-15-24-21)17-8-6-9-18(22)12-17/h5-13,15H,3-4,14,22H2,1-2H3,(H,23,24,25) SFSDWINHMMLVKI-UHFFFAOYSA-N 50013443 CHEMBL3264113 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 327 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013443&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580044 242058249 CHEMBL3264113 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094736 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1)OCC InChI=1S/C22H27N4O2P/c1-3-11-29(27,28-4-2)15-17-7-5-10-20(12-17)26-22-14-21(24-16-25-22)18-8-6-9-19(23)13-18/h5-10,12-14,16H,3-4,11,15,23H2,1-2H3,(H,24,25,26) ROMWISXCKBTPPA-UHFFFAOYSA-N 50013445 CHEMBL3264114 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 682 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580063 242058250 CHEMBL3264114 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094737 CCOP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1)c1ccccc1 InChI=1S/C25H25N4O2P/c1-2-31-32(30,23-12-4-3-5-13-23)17-19-8-6-11-22(14-19)29-25-16-24(27-18-28-25)20-9-7-10-21(26)15-20/h3-16,18H,2,17,26H2,1H3,(H,27,28,29) HSGUPAGFYAWDAY-UHFFFAOYSA-N 50013446 CHEMBL3259863 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1019 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580064 242058251 CHEMBL3259863 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094738 CCOP(=O)(CC)Cc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C22H26N3O3P/c1-4-28-29(26,5-2)15-17-10-12-18(13-11-17)25-22-14-20(23-16-24-22)19-8-6-7-9-21(19)27-3/h6-14,16H,4-5,15H2,1-3H3,(H,23,24,25) HQXFWJDXROHJFM-UHFFFAOYSA-N 50013447 CHEMBL3264115 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 743 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013447&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580065 242058252 CHEMBL3264115 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094739 CCCP(=O)(Cc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1)OCC InChI=1S/C23H28N3O3P/c1-4-14-30(27,29-5-2)16-18-10-12-19(13-11-18)26-23-15-21(24-17-25-23)20-8-6-7-9-22(20)28-3/h6-13,15,17H,4-5,14,16H2,1-3H3,(H,24,25,26) LQIQHMBVHUJCSN-UHFFFAOYSA-N 50013448 CHEMBL3264116 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 652 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013448&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580086 242058253 CHEMBL3264116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094740 CCOP(=O)(CC)Cc1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C21H23N4O4P/c1-3-29-30(28,4-2)14-16-8-10-18(11-9-16)24-21-13-20(22-15-23-21)17-6-5-7-19(12-17)25(26)27/h5-13,15H,3-4,14H2,1-2H3,(H,22,23,24) YNSUEMNXVUMMKD-UHFFFAOYSA-N 50013449 CHEMBL3264117 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7774 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580089 242058254 CHEMBL3264117 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094741 CCCP(=O)(Cc1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1)OCC InChI=1S/C22H25N4O4P/c1-3-12-31(29,30-4-2)15-17-8-10-19(11-9-17)25-22-14-21(23-16-24-22)18-6-5-7-20(13-18)26(27)28/h5-11,13-14,16H,3-4,12,15H2,1-2H3,(H,23,24,25) JZVPTAZYTCXRSM-UHFFFAOYSA-N 50013450 CHEMBL3264118 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5525 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013450&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580090 242058255 CHEMBL3264118 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094742 CCOP(=O)(CC)Cc1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C21H25N4O2P/c1-3-27-28(26,4-2)14-16-8-10-19(11-9-16)25-21-13-20(23-15-24-21)17-6-5-7-18(22)12-17/h5-13,15H,3-4,14,22H2,1-2H3,(H,23,24,25) DDNQLWZUJVTHRI-UHFFFAOYSA-N 50013451 CHEMBL3264119 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7533 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013451&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580109 242058256 CHEMBL3264119 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094743 CCCP(=O)(Cc1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1)OCC InChI=1S/C22H27N4O2P/c1-3-12-29(27,28-4-2)15-17-8-10-20(11-9-17)26-22-14-21(24-16-25-22)18-6-5-7-19(23)13-18/h5-11,13-14,16H,3-4,12,15,23H2,1-2H3,(H,24,25,26) OQHQQBQSQYDIMD-UHFFFAOYSA-N 50013452 CHEMBL3264120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7474 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013452&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580110 242058257 CHEMBL3264120 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094744 CCOP(=O)(CC)Cc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C InChI=1S/C23H28N3O3P/c1-5-29-30(27,6-2)15-18-13-19(12-11-17(18)3)26-23-14-21(24-16-25-23)20-9-7-8-10-22(20)28-4/h7-14,16H,5-6,15H2,1-4H3,(H,24,25,26) RGDYNFMUBLZLPH-UHFFFAOYSA-N 50013453 CHEMBL3264121 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 366 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013453&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580112 242058258 CHEMBL3264121 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094745 CCOP(=O)(CC)Cc1cc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)ccc1C InChI=1S/C22H25N4O4P/c1-4-30-31(29,5-2)14-18-11-19(10-9-16(18)3)25-22-13-21(23-15-24-22)17-7-6-8-20(12-17)26(27)28/h6-13,15H,4-5,14H2,1-3H3,(H,23,24,25) YDDFGIBZAMJXRH-UHFFFAOYSA-N 50013454 CHEMBL3264122 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7022 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580113 242058259 CHEMBL3264122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094746 CCOP(=O)(CC)Cc1cc(Nc2cc(ncn2)-c2cccc(N)c2)ccc1C InChI=1S/C22H27N4O2P/c1-4-28-29(27,5-2)14-18-12-20(10-9-16(18)3)26-22-13-21(24-15-25-22)17-7-6-8-19(23)11-17/h6-13,15H,4-5,14,23H2,1-3H3,(H,24,25,26) IISOQYAOTJHYJA-UHFFFAOYSA-N 50013455 CHEMBL3264123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 346 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013455&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580114 242058260 CHEMBL3264123 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094747 CCCP(O)(=O)Cc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1 InChI=1S/C21H24N3O3P/c1-3-11-28(25,26)14-16-7-6-8-17(12-16)24-21-13-19(22-15-23-21)18-9-4-5-10-20(18)27-2/h4-10,12-13,15H,3,11,14H2,1-2H3,(H,25,26)(H,22,23,24) CQZOWVMFPZAQFL-UHFFFAOYSA-N 50013456 CHEMBL3264124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 261 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580130 242058261 CHEMBL3264124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094748 CCOP(=O)(CC)c1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1 InChI=1S/C21H24N3O3P/c1-4-27-28(25,5-2)17-10-8-9-16(13-17)24-21-14-19(22-15-23-21)18-11-6-7-12-20(18)26-3/h6-15H,4-5H2,1-3H3,(H,22,23,24) FULJYHFEQCLTOG-UHFFFAOYSA-N 50013457 CHEMBL3264125 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 842 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013457&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580131 242058262 CHEMBL3264125 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094749 CCOP(=O)(CC)c1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C20H21N4O4P/c1-3-28-29(27,4-2)18-10-6-8-16(12-18)23-20-13-19(21-14-22-20)15-7-5-9-17(11-15)24(25)26/h5-14H,3-4H2,1-2H3,(H,21,22,23) GAYQBHLKAGEUGS-UHFFFAOYSA-N 50013458 CHEMBL3264126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580132 242058263 CHEMBL3264126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094750 CCOP(=O)(CC)c1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1 InChI=1S/C20H23N4O2P/c1-3-26-27(25,4-2)18-10-6-9-17(12-18)24-20-13-19(22-14-23-20)15-7-5-8-16(21)11-15/h5-14H,3-4,21H2,1-2H3,(H,22,23,24) YSBBCYQVQXQJLZ-UHFFFAOYSA-N 50013459 CHEMBL3264127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9802 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013459&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580133 103925609 CHEMBL3264127 ZINC03787606 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094751 CCOP(=O)(CC)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C21H24N3O3P/c1-4-27-28(25,5-2)17-12-10-16(11-13-17)24-21-14-19(22-15-23-21)18-8-6-7-9-20(18)26-3/h6-15H,4-5H2,1-3H3,(H,22,23,24) VSRDDEIEFMDGOS-UHFFFAOYSA-N 50013460 CHEMBL3264128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 418 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580134 242058264 CHEMBL3264128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094752 CCCP(=O)(OCC)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C22H26N3O3P/c1-4-14-29(26,28-5-2)18-12-10-17(11-13-18)25-22-15-20(23-16-24-22)19-8-6-7-9-21(19)27-3/h6-13,15-16H,4-5,14H2,1-3H3,(H,23,24,25) HHPMNGJSIDSQBK-UHFFFAOYSA-N 50013461 CHEMBL3264129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1149 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013461&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580135 242058265 CHEMBL3264129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094753 CCOP(=O)(c1ccccc1)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C25H24N3O3P/c1-3-31-32(29,20-9-5-4-6-10-20)21-15-13-19(14-16-21)28-25-17-23(26-18-27-25)22-11-7-8-12-24(22)30-2/h4-18H,3H2,1-2H3,(H,26,27,28) MNVXWIJLBYLPNE-UHFFFAOYSA-N 50013462 CHEMBL3264130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 523 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580154 242058266 CHEMBL3264130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094754 CCOP(=O)(CC)c1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C20H21N4O4P/c1-3-28-29(27,4-2)18-10-8-16(9-11-18)23-20-13-19(21-14-22-20)15-6-5-7-17(12-15)24(25)26/h5-14H,3-4H2,1-2H3,(H,21,22,23) XITIJGLLZSRAHY-UHFFFAOYSA-N 50013463 CHEMBL3264131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580155 242058267 CHEMBL3264131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094755 CCCP(=O)(OCC)c1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C21H23N4O4P/c1-3-12-30(28,29-4-2)19-10-8-17(9-11-19)24-21-14-20(22-15-23-21)16-6-5-7-18(13-16)25(26)27/h5-11,13-15H,3-4,12H2,1-2H3,(H,22,23,24) SIQJWDUWLRBXMR-UHFFFAOYSA-N 50013464 CHEMBL3264132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013464&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580156 242058268 CHEMBL3264132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094756 CCOP(=O)(c1ccccc1)c1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C24H21N4O4P/c1-2-32-33(31,21-9-4-3-5-10-21)22-13-11-19(12-14-22)27-24-16-23(25-17-26-24)18-7-6-8-20(15-18)28(29)30/h3-17H,2H2,1H3,(H,25,26,27) OBGHHCYRUBRTRT-UHFFFAOYSA-N 50013465 CHEMBL3264133 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013465&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580157 242058269 CHEMBL3264133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094757 CCOP(=O)(CC)c1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C20H23N4O2P/c1-3-26-27(25,4-2)18-10-8-17(9-11-18)24-20-13-19(22-14-23-20)15-6-5-7-16(21)12-15/h5-14H,3-4,21H2,1-2H3,(H,22,23,24) JAOYQONKKWYRTM-UHFFFAOYSA-N 50013466 CHEMBL3264134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013466&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580158 242058270 CHEMBL3264134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094758 CCCP(=O)(OCC)c1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C21H25N4O2P/c1-3-12-28(26,27-4-2)19-10-8-18(9-11-19)25-21-14-20(23-15-24-21)16-6-5-7-17(22)13-16/h5-11,13-15H,3-4,12,22H2,1-2H3,(H,23,24,25) OMJGZAMYZHBSAE-UHFFFAOYSA-N 50013467 CHEMBL3264135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013467&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580174 242058271 CHEMBL3264135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094759 CCOP(=O)(c1ccccc1)c1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C24H23N4O2P/c1-2-30-31(29,21-9-4-3-5-10-21)22-13-11-20(12-14-22)28-24-16-23(26-17-27-24)18-7-6-8-19(25)15-18/h3-17H,2,25H2,1H3,(H,26,27,28) BEPNQRUVSGZKOU-UHFFFAOYSA-N 50013468 CHEMBL3264136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6501 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013468&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580175 242058272 CHEMBL3264136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094760 CCOP(=O)(OCC)c1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1 InChI=1S/C21H24N3O4P/c1-4-27-29(25,28-5-2)17-10-8-9-16(13-17)24-21-14-19(22-15-23-21)18-11-6-7-12-20(18)26-3/h6-15H,4-5H2,1-3H3,(H,22,23,24) NXQWKBTULGIQSQ-UHFFFAOYSA-N 50013469 CHEMBL3264137 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1040 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013469&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580176 242058273 CHEMBL3264137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094761 CCOP(=O)(OCC)c1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C20H21N4O5P/c1-3-28-30(27,29-4-2)18-10-6-8-16(12-18)23-20-13-19(21-14-22-20)15-7-5-9-17(11-15)24(25)26/h5-14H,3-4H2,1-2H3,(H,21,22,23) PTJSRCCTIQSMGD-UHFFFAOYSA-N 50013470 CHEMBL3264138 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580177 242058274 CHEMBL3264138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094762 CCOP(=O)(OCC)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C21H24N3O4P/c1-4-27-29(25,28-5-2)17-12-10-16(11-13-17)24-21-14-19(22-15-23-21)18-8-6-7-9-20(18)26-3/h6-15H,4-5H2,1-3H3,(H,22,23,24) MMAGFOCFXQXAJC-UHFFFAOYSA-N 50013471 CHEMBL3264139 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1020 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013471&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580178 242058275 CHEMBL3264139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094763 CCOP(=O)(OCC)c1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C20H21N4O5P/c1-3-28-30(27,29-4-2)18-10-8-16(9-11-18)23-20-13-19(21-14-22-20)15-6-5-7-17(12-15)24(25)26/h5-14H,3-4H2,1-2H3,(H,21,22,23) MRUPDESYMWVYKA-UHFFFAOYSA-N 50013472 CHEMBL3264140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013472&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580200 242058276 CHEMBL3264140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094764 CCOP(=O)(OCC)c1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C20H23N4O3P/c1-3-26-28(25,27-4-2)18-10-8-17(9-11-18)24-20-13-19(22-14-23-20)15-6-5-7-16(21)12-15/h5-14H,3-4,21H2,1-2H3,(H,22,23,24) AGLDGUHPJIPKAN-UHFFFAOYSA-N 50013473 CHEMBL3264141 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013473&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580201 242058277 CHEMBL3264141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094765 COc1ccccc1-c1cc(Nc2cccc(c2)P(O)(O)=O)ncn1 InChI=1S/C17H16N3O4P/c1-24-16-8-3-2-7-14(16)15-10-17(19-11-18-15)20-12-5-4-6-13(9-12)25(21,22)23/h2-11H,1H3,(H,18,19,20)(H2,21,22,23) KEJSIFQISWZRTF-UHFFFAOYSA-N 50013474 CHEMBL3264142 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 429 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013474&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580202 242058278 CHEMBL3264142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094766 OP(O)(=O)c1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C16H13N4O5P/c21-20(22)13-5-1-3-11(7-13)15-9-16(18-10-17-15)19-12-4-2-6-14(8-12)26(23,24)25/h1-10H,(H,17,18,19)(H2,23,24,25) ZATQGCMCRXRALQ-UHFFFAOYSA-N 50013476 CHEMBL3264143 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4100 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013476&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580203 242058279 CHEMBL3264143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094767 COc1ccccc1-c1cc(Nc2ccc(cc2)P(O)(O)=O)ncn1 InChI=1S/C17H16N3O4P/c1-24-16-5-3-2-4-14(16)15-10-17(19-11-18-15)20-12-6-8-13(9-7-12)25(21,22)23/h2-11H,1H3,(H,18,19,20)(H2,21,22,23) QIQFLIODWFABIX-UHFFFAOYSA-N 50013477 CHEMBL3264144 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 580 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013477&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580204 103925611 CHEMBL3264144 ZINC34614605 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094768 Nc1cccc(c1)-c1cc(Nc2ccc(cc2)P(O)(O)=O)ncn1 InChI=1S/C16H15N4O3P/c17-12-3-1-2-11(8-12)15-9-16(19-10-18-15)20-13-4-6-14(7-5-13)24(21,22)23/h1-10H,17H2,(H,18,19,20)(H2,21,22,23) RDMRWYXFPSVLLR-UHFFFAOYSA-N 50013478 CHEMBL3264145 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3320 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013478&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580205 103925612 CHEMBL3264145 ZINC34614601 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094769 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2OCC)c1)OCC InChI=1S/C24H30N3O3P/c1-4-14-31(28,30-6-3)17-19-10-9-11-20(15-19)27-24-16-22(25-18-26-24)21-12-7-8-13-23(21)29-5-2/h7-13,15-16,18H,4-6,14,17H2,1-3H3,(H,25,26,27) SGDFLHLRJKFCHD-UHFFFAOYSA-N 50013479 CHEMBL3264146 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 254 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013479&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580206 103925613 CHEMBL3264146 ZINC25996359 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094770 CCCOc1ccccc1-c1cc(Nc2cccc(CP(=O)(CCC)OCC)c2)ncn1 InChI=1S/C25H32N3O3P/c1-4-14-30-24-13-8-7-12-22(24)23-17-25(27-19-26-23)28-21-11-9-10-20(16-21)18-32(29,15-5-2)31-6-3/h7-13,16-17,19H,4-6,14-15,18H2,1-3H3,(H,26,27,28) PMDRPCHUVAKILA-UHFFFAOYSA-N 50013480 CHEMBL3264147 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 248 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580236 103925614 CHEMBL3264147 ZINC34614620 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094771 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2OC(C)C)c1)OCC InChI=1S/C25H32N3O3P/c1-5-14-32(29,30-6-2)17-20-10-9-11-21(15-20)28-25-16-23(26-18-27-25)22-12-7-8-13-24(22)31-19(3)4/h7-13,15-16,18-19H,5-6,14,17H2,1-4H3,(H,26,27,28) VYQIKCMDFFPYEF-UHFFFAOYSA-N 50013481 CHEMBL3264148 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013481&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580237 103925615 CHEMBL3264148 ZINC25994628 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094772 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2Oc2ccccc2)c1)OCC InChI=1S/C28H30N3O3P/c1-3-17-35(32,33-4-2)20-22-11-10-12-23(18-22)31-28-19-26(29-21-30-28)25-15-8-9-16-27(25)34-24-13-6-5-7-14-24/h5-16,18-19,21H,3-4,17,20H2,1-2H3,(H,29,30,31) WHWKCUSCYHGQCV-UHFFFAOYSA-N 50013482 CHEMBL3264149 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 601 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013482&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580238 103925616 CHEMBL3264149 ZINC36011781 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094773 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)c1)OCC InChI=1S/C29H32N3O3P/c1-3-17-36(33,35-4-2)21-24-13-10-14-25(18-24)32-29-19-27(30-22-31-29)26-15-8-9-16-28(26)34-20-23-11-6-5-7-12-23/h5-16,18-19,22H,3-4,17,20-21H2,1-2H3,(H,30,31,32) YYTWRZPWDPTELP-UHFFFAOYSA-N 50013483 CHEMBL3264150 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 143 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013483&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580239 103925617 CHEMBL3264150 ZINC34614597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094774 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(OC)c2)c1)OCC InChI=1S/C23H28N3O3P/c1-4-12-30(27,29-5-2)16-18-8-6-10-20(13-18)26-23-15-22(24-17-25-23)19-9-7-11-21(14-19)28-3/h6-11,13-15,17H,4-5,12,16H2,1-3H3,(H,24,25,26) GGYOKBKAFSOLMI-UHFFFAOYSA-N 50013484 CHEMBL3264151 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6937 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013484&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580240 103925618 CHEMBL3264151 ZINC26000015 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094775 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccc(OC)cc2)c1)OCC InChI=1S/C23H28N3O3P/c1-4-13-30(27,29-5-2)16-18-7-6-8-20(14-18)26-23-15-22(24-17-25-23)19-9-11-21(28-3)12-10-19/h6-12,14-15,17H,4-5,13,16H2,1-3H3,(H,24,25,26) PHPONDAEOPOMOY-UHFFFAOYSA-N 50013485 CHEMBL3264152 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5414 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013485&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580241 103925619 CHEMBL3264152 ZINC36011778 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094776 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(OC)c2OC)c1)OCC InChI=1S/C24H30N3O4P/c1-5-13-32(28,31-6-2)16-18-9-7-10-19(14-18)27-23-15-21(25-17-26-23)20-11-8-12-22(29-3)24(20)30-4/h7-12,14-15,17H,5-6,13,16H2,1-4H3,(H,25,26,27) FYZUJJXBUSXQJJ-UHFFFAOYSA-N 50013486 CHEMBL3264153 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2387 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013486&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580265 103925620 CHEMBL3264153 ZINC13887103 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094777 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)c1)OCC InChI=1S/C23H27FN3O3P/c1-4-11-31(28,30-5-2)15-17-7-6-8-19(12-17)27-23-14-21(25-16-26-23)20-10-9-18(24)13-22(20)29-3/h6-10,12-14,16H,4-5,11,15H2,1-3H3,(H,25,26,27) DTXVXBZQJXIHJX-UHFFFAOYSA-N 50013487 CHEMBL3264154 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 186 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013487&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580266 103925621 CHEMBL3264154 ZINC36761196 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094778 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(OCc3ccccc3)c2)c1)OCC InChI=1S/C29H32N3O3P/c1-3-16-36(33,35-4-2)21-24-12-8-14-26(17-24)32-29-19-28(30-22-31-29)25-13-9-15-27(18-25)34-20-23-10-6-5-7-11-23/h5-15,17-19,22H,3-4,16,20-21H2,1-2H3,(H,30,31,32) HLTPFCPTMAFNTA-UHFFFAOYSA-N 50013488 CHEMBL3264155 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013488&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580267 103925622 CHEMBL3264155 ZINC34614603 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094779 CCCP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2CC)c1)OCC InChI=1S/C24H30N3O2P/c1-4-14-30(28,29-6-3)17-19-10-9-12-21(15-19)27-24-16-23(25-18-26-24)22-13-8-7-11-20(22)5-2/h7-13,15-16,18H,4-6,14,17H2,1-3H3,(H,25,26,27) VIDNWGHMNFOVGU-UHFFFAOYSA-N 50013489 CHEMBL3264156 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013489&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580268 103925623 CHEMBL3264156 ZINC25994643 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094780 CCOP(=O)(CC)Cc1cccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)c1 InChI=1S/C28H30N3O3P/c1-3-34-35(32,4-2)20-23-13-10-14-24(17-23)31-28-18-26(29-21-30-28)25-15-8-9-16-27(25)33-19-22-11-6-5-7-12-22/h5-18,21H,3-4,19-20H2,1-2H3,(H,29,30,31) LDLGEHYWPPYLOH-UHFFFAOYSA-N 50013490 CHEMBL3264157 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 212 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013490&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580269 103925624 CHEMBL3264157 ZINC36011779 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094781 CCP(O)(=O)Cc1cccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)c1 InChI=1S/C26H26N3O3P/c1-2-33(30,31)18-21-11-8-12-22(15-21)29-26-16-24(27-19-28-26)23-13-6-7-14-25(23)32-17-20-9-4-3-5-10-20/h3-16,19H,2,17-18H2,1H3,(H,30,31)(H,27,28,29) WBVGUWUOTGUKKV-UHFFFAOYSA-N 50013491 CHEMBL3264158 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 163 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013491&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580270 103925625 CHEMBL3264158 ZINC25757829 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094782 CCCP(O)(=O)Cc1cccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)c1 InChI=1S/C27H28N3O3P/c1-2-15-34(31,32)19-22-11-8-12-23(16-22)30-27-17-25(28-20-29-27)24-13-6-7-14-26(24)33-18-21-9-4-3-5-10-21/h3-14,16-17,20H,2,15,18-19H2,1H3,(H,31,32)(H,28,29,30) IIZHHHNHDPJHJK-UHFFFAOYSA-N 50013492 CHEMBL3264159 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 142 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013492&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580300 103925626 CHEMBL3264159 ZINC26000955 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094783 Cc1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1NS(C)(=O)=O InChI=1S/C18H19N5O2S/c1-12-6-7-15(9-16(12)23-26(2,24)25)22-18-10-17(20-11-21-18)13-4-3-5-14(19)8-13/h3-11,23H,19H2,1-2H3,(H,20,21,22) OZMZPDYRMXRPPJ-UHFFFAOYSA-N 50013507 CHEMBL3263769 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 129 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013507&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11748985 242058280 CHEMBL3263769 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094784 COc1ccccc1-c1cc(Nc2cccc(NS(N)(=O)=O)c2)ncn1 InChI=1S/C17H17N5O3S/c1-25-16-8-3-2-7-14(16)15-10-17(20-11-19-15)21-12-5-4-6-13(9-12)22-26(18,23)24/h2-11,22H,1H3,(H2,18,23,24)(H,19,20,21) CLNKTAGHOZUCSU-UHFFFAOYSA-N 50013508 CHEMBL3263771 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013508&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580301 242058281 CHEMBL3263771 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094785 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094786 COc1ccccc1-c1cc(Nc2ccc(C)c(NS(C)(=O)=O)c2)ncn1 InChI=1S/C19H20N4O3S/c1-13-8-9-14(10-16(13)23-27(3,24)25)22-19-11-17(20-12-21-19)15-6-4-5-7-18(15)26-2/h4-12,23H,1-3H3,(H,20,21,22) YUTLWCQIOXIPAP-UHFFFAOYSA-N 50013509 CHEMBL3263770 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013509&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 68915223 242058282 CHEMBL3263770 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094787 COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1 InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22) GGQCIOOSELPMBB-UHFFFAOYSA-N 50013510 CHEMBL3263773 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013510&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25104564 242058283 CHEMBL3263773 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094788 CCOP(=O)(CC)Nc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C InChI=1S/C22H27N4O3P/c1-5-29-30(27,6-2)26-19-13-17(12-11-16(19)3)25-22-14-20(23-15-24-22)18-9-7-8-10-21(18)28-4/h7-15H,5-6H2,1-4H3,(H,26,27)(H,23,24,25) PHEKZJHSQCVART-UHFFFAOYSA-N 50013511 CHEMBL3263774 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1450 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013511&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90656365 242058284 CHEMBL3263774 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094789 CCCP(=O)(Nc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C)OC(C)C InChI=1S/C24H31N4O3P/c1-6-13-32(29,31-17(2)3)28-21-14-19(12-11-18(21)4)27-24-15-22(25-16-26-24)20-9-7-8-10-23(20)30-5/h7-12,14-17H,6,13H2,1-5H3,(H,28,29)(H,25,26,27) UBYPSAZWXXDEJR-UHFFFAOYSA-N 50013512 CHEMBL3263775 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3170 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013512&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90656366 242058285 CHEMBL3263775 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094790 CCOP(=O)(Nc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C)c1ccccc1 InChI=1S/C26H27N4O3P/c1-4-33-34(31,21-10-6-5-7-11-21)30-23-16-20(15-14-19(23)2)29-26-17-24(27-18-28-26)22-12-8-9-13-25(22)32-3/h5-18H,4H2,1-3H3,(H,30,31)(H,27,28,29) YLTVVHWRXJENCY-UHFFFAOYSA-N 50013513 CHEMBL3263776 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5240 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013513&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90656367 242058286 CHEMBL3263776 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094791 CCOP(=O)(CC)Oc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C InChI=1S/C22H26N3O4P/c1-5-28-30(26,6-2)29-21-13-17(12-11-16(21)3)25-22-14-19(23-15-24-22)18-9-7-8-10-20(18)27-4/h7-15H,5-6H2,1-4H3,(H,23,24,25) FFEQNPCJYJGKNN-UHFFFAOYSA-N 50013514 CHEMBL3263777 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 813 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013514&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580194 242058287 CHEMBL3263777 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094792 CCCP(=O)(OC(C)C)Oc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C InChI=1S/C24H30N3O4P/c1-6-13-32(28,30-17(2)3)31-23-14-19(12-11-18(23)4)27-24-15-21(25-16-26-24)20-9-7-8-10-22(20)29-5/h7-12,14-17H,6,13H2,1-5H3,(H,25,26,27) CWLOFVNIEMBYAP-UHFFFAOYSA-N 50013571 CHEMBL3263778 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3057 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580195 242058288 CHEMBL3263778 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094793 CCOP(=O)(Oc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C)c1ccccc1 InChI=1S/C26H26N3O4P/c1-4-32-34(30,21-10-6-5-7-11-21)33-25-16-20(15-14-19(25)2)29-26-17-23(27-18-28-26)22-12-8-9-13-24(22)31-3/h5-18H,4H2,1-3H3,(H,27,28,29) YNLWQTOQBDPTMF-UHFFFAOYSA-N 50013572 CHEMBL3263779 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4137 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580196 242058289 CHEMBL3263779 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094794 CCOP(=O)(CC)Oc1cc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)ccc1C InChI=1S/C21H23N4O5P/c1-4-29-31(28,5-2)30-20-12-17(10-9-15(20)3)24-21-13-19(22-14-23-21)16-7-6-8-18(11-16)25(26)27/h6-14H,4-5H2,1-3H3,(H,22,23,24) YNJROUQEUUCJFW-UHFFFAOYSA-N 50013573 CHEMBL3263780 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580197 242058290 CHEMBL3263780 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094795 CCCP(=O)(OC(C)C)Oc1cc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)ccc1C InChI=1S/C23H27N4O5P/c1-5-11-33(30,31-16(2)3)32-22-13-19(10-9-17(22)4)26-23-14-21(24-15-25-23)18-7-6-8-20(12-18)27(28)29/h6-10,12-16H,5,11H2,1-4H3,(H,24,25,26) SWAJCYBPFLTGBY-UHFFFAOYSA-N 50013574 CHEMBL3263781 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013574&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580199 242058291 CHEMBL3263781 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094796 CCOP(=O)(CC)Oc1cc(Nc2cc(ncn2)-c2cccc(N)c2)ccc1C InChI=1S/C21H25N4O3P/c1-4-27-29(26,5-2)28-20-12-18(10-9-15(20)3)25-21-13-19(23-14-24-21)16-7-6-8-17(22)11-16/h6-14H,4-5,22H2,1-3H3,(H,23,24,25) SCHBPDAYSDOLDG-UHFFFAOYSA-N 50013575 CHEMBL3263782 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 870 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013575&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580230 242058292 CHEMBL3263782 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094797 CCCP(=O)(OC(C)C)Oc1cc(Nc2cc(ncn2)-c2cccc(N)c2)ccc1C InChI=1S/C23H29N4O3P/c1-5-11-31(28,29-16(2)3)30-22-13-20(10-9-17(22)4)27-23-14-21(25-15-26-23)18-7-6-8-19(24)12-18/h6-10,12-16H,5,11,24H2,1-4H3,(H,25,26,27) XDTZUTSIYMNRNT-UHFFFAOYSA-N 50013576 CHEMBL3263783 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5385 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013576&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580232 242058293 CHEMBL3263783 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094798 CCOP(=O)(CC)Oc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1 InChI=1S/C21H24N3O4P/c1-4-27-29(25,5-2)28-17-10-8-9-16(13-17)24-21-14-19(22-15-23-21)18-11-6-7-12-20(18)26-3/h6-15H,4-5H2,1-3H3,(H,22,23,24) OLXVAZQUMZMLIA-UHFFFAOYSA-N 50013577 CHEMBL3263784 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 400 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580295 242058294 CHEMBL3263784 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094799 CCCP(=O)(OC(C)C)Oc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1 InChI=1S/C23H28N3O4P/c1-5-13-31(27,29-17(2)3)30-19-10-8-9-18(14-19)26-23-15-21(24-16-25-23)20-11-6-7-12-22(20)28-4/h6-12,14-17H,5,13H2,1-4H3,(H,24,25,26) RRNUOCBAJJWWDG-UHFFFAOYSA-N 50013578 CHEMBL3263785 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1180 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580296 242058295 CHEMBL3263785 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094800 CCOP(=O)(Oc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1)c1ccccc1 InChI=1S/C25H24N3O4P/c1-3-31-33(29,21-12-5-4-6-13-21)32-20-11-9-10-19(16-20)28-25-17-23(26-18-27-25)22-14-7-8-15-24(22)30-2/h4-18H,3H2,1-2H3,(H,26,27,28) VGOZIOWLGITAPV-UHFFFAOYSA-N 50013579 CHEMBL3263786 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3100 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580297 242058296 CHEMBL3263786 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094801 CCOP(=O)(CC)Oc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C20H21N4O5P/c1-3-28-30(27,4-2)29-18-10-6-8-16(12-18)23-20-13-19(21-14-22-20)15-7-5-9-17(11-15)24(25)26/h5-14H,3-4H2,1-2H3,(H,21,22,23) NWOBGLYXMKQYMX-UHFFFAOYSA-N 50013580 CHEMBL3263787 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580298 242058297 CHEMBL3263787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094802 CCCP(=O)(OC(C)C)Oc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C22H25N4O5P/c1-4-11-32(29,30-16(2)3)31-20-10-6-8-18(13-20)25-22-14-21(23-15-24-22)17-7-5-9-19(12-17)26(27)28/h5-10,12-16H,4,11H2,1-3H3,(H,23,24,25) FVVHUJCPPABXQY-UHFFFAOYSA-N 50013581 CHEMBL3263788 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013581&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580299 242058298 CHEMBL3263788 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094803 CCOP(=O)(Oc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1)c1ccccc1 InChI=1S/C24H21N4O5P/c1-2-32-34(31,22-12-4-3-5-13-22)33-21-11-7-9-19(15-21)27-24-16-23(25-17-26-24)18-8-6-10-20(14-18)28(29)30/h3-17H,2H2,1H3,(H,25,26,27) GEZOLHISBFTXIQ-UHFFFAOYSA-N 50013582 CHEMBL3263789 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580319 242058299 CHEMBL3263789 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094804 CCOP(=O)(CC)Oc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1 InChI=1S/C20H23N4O3P/c1-3-26-28(25,4-2)27-18-10-6-9-17(12-18)24-20-13-19(22-14-23-20)15-7-5-8-16(21)11-15/h5-14H,3-4,21H2,1-2H3,(H,22,23,24) BNWOQXJTPNAVJT-UHFFFAOYSA-N 50013583 CHEMBL3263790 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1800 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013583&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580320 242058300 CHEMBL3263790 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094805 CCCP(=O)(OC(C)C)Oc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1 InChI=1S/C22H27N4O3P/c1-4-11-30(27,28-16(2)3)29-20-10-6-9-19(13-20)26-22-14-21(24-15-25-22)17-7-5-8-18(23)12-17/h5-10,12-16H,4,11,23H2,1-3H3,(H,24,25,26) UINFXCUMIZPWMP-UHFFFAOYSA-N 50013584 CHEMBL3263791 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6430 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580321 242058301 CHEMBL3263791 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094806 CCOP(=O)(Oc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1)c1ccccc1 InChI=1S/C24H23N4O3P/c1-2-30-32(29,22-12-4-3-5-13-22)31-21-11-7-10-20(15-21)28-24-16-23(26-17-27-24)18-8-6-9-19(25)14-18/h3-17H,2,25H2,1H3,(H,26,27,28) LMLJIAFLINXBFT-UHFFFAOYSA-N 50013585 CHEMBL3263792 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5330 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580323 242058302 CHEMBL3263792 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094807 CCOP(=O)(CC)Oc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C21H24N3O4P/c1-4-27-29(25,5-2)28-17-12-10-16(11-13-17)24-21-14-19(22-15-23-21)18-8-6-7-9-20(18)26-3/h6-15H,4-5H2,1-3H3,(H,22,23,24) FJNJKOBOWGABEB-UHFFFAOYSA-N 50013586 CHEMBL3263793 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 360 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013586&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579886 242058303 CHEMBL3263793 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094808 CCCP(=O)(OC(C)C)Oc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C23H28N3O4P/c1-5-14-31(27,29-17(2)3)30-19-12-10-18(11-13-19)26-23-15-21(24-16-25-23)20-8-6-7-9-22(20)28-4/h6-13,15-17H,5,14H2,1-4H3,(H,24,25,26) ANYFFTINPHKPKX-UHFFFAOYSA-N 50013587 CHEMBL3263794 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 407 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579887 242058304 CHEMBL3263794 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094809 CCOP(=O)(Oc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1)c1ccccc1 InChI=1S/C25H24N3O4P/c1-3-31-33(29,21-9-5-4-6-10-21)32-20-15-13-19(14-16-20)28-25-17-23(26-18-27-25)22-11-7-8-12-24(22)30-2/h4-18H,3H2,1-2H3,(H,26,27,28) NIXSZQKMFCIGCY-UHFFFAOYSA-N 50013588 CHEMBL3263795 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2840 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579888 242058305 CHEMBL3263795 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094810 CCOP(=O)(CC)Oc1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C20H21N4O5P/c1-3-28-30(27,4-2)29-18-10-8-16(9-11-18)23-20-13-19(21-14-22-20)15-6-5-7-17(12-15)24(25)26/h5-14H,3-4H2,1-2H3,(H,21,22,23) YSNCEPKRXMFOER-UHFFFAOYSA-N 50013589 CHEMBL3263796 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579889 242058306 CHEMBL3263796 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094811 CCCP(=O)(OC(C)C)Oc1ccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C22H25N4O5P/c1-4-12-32(29,30-16(2)3)31-20-10-8-18(9-11-20)25-22-14-21(23-15-24-22)17-6-5-7-19(13-17)26(27)28/h5-11,13-16H,4,12H2,1-3H3,(H,23,24,25) WQSBUARVLZGAFF-UHFFFAOYSA-N 50013590 CHEMBL3263797 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013590&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579890 242058307 CHEMBL3263797 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094812 CCOP(=O)(CC)Oc1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C20H23N4O3P/c1-3-26-28(25,4-2)27-18-10-8-17(9-11-18)24-20-13-19(22-14-23-20)15-6-5-7-16(21)12-15/h5-14H,3-4,21H2,1-2H3,(H,22,23,24) AEINXYJDBHHARD-UHFFFAOYSA-N 50013591 CHEMBL3263798 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3840 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579891 242058308 CHEMBL3263798 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094813 CCCP(=O)(OC(C)C)Oc1ccc(Nc2cc(ncn2)-c2cccc(N)c2)cc1 InChI=1S/C22H27N4O3P/c1-4-12-30(27,28-16(2)3)29-20-10-8-19(9-11-20)26-22-14-21(24-15-25-22)17-6-5-7-18(23)13-17/h5-11,13-16H,4,12,23H2,1-3H3,(H,24,25,26) DJQLBHYKVPCUPQ-UHFFFAOYSA-N 50013592 CHEMBL3263799 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6060 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013592&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579927 242058309 CHEMBL3263799 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094814 CCP(O)(=O)Oc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C InChI=1S/C20H22N3O4P/c1-4-28(24,25)27-19-11-15(10-9-14(19)2)23-20-12-17(21-13-22-20)16-7-5-6-8-18(16)26-3/h5-13H,4H2,1-3H3,(H,24,25)(H,21,22,23) ABZZHDPGVFGOHO-UHFFFAOYSA-N 50013593 CHEMBL3263800 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1490 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013593&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579928 242058310 CHEMBL3263800 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094815 CCCP(O)(=O)Oc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C InChI=1S/C21H24N3O4P/c1-4-11-29(25,26)28-20-12-16(10-9-15(20)2)24-21-13-18(22-14-23-21)17-7-5-6-8-19(17)27-3/h5-10,12-14H,4,11H2,1-3H3,(H,25,26)(H,22,23,24) AHGGHNRODGIMKU-UHFFFAOYSA-N 50013594 CHEMBL3263801 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1457 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013594&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579929 242058311 CHEMBL3263801 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094816 CCOP(=O)(Cc1cccc(Nc2cc(ncn2)-c2ccccc2OC)c1)OCC InChI=1S/C22H26N3O4P/c1-4-28-30(26,29-5-2)15-17-9-8-10-18(13-17)25-22-14-20(23-16-24-22)19-11-6-7-12-21(19)27-3/h6-14,16H,4-5,15H2,1-3H3,(H,23,24,25) QWNLXFWRYMIBSP-UHFFFAOYSA-N 50013595 CHEMBL3263802 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 333 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013595&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579930 242058312 CHEMBL3263802 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094817 CCOP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1)OCC InChI=1S/C21H23N4O5P/c1-3-29-31(28,30-4-2)14-16-7-5-9-18(11-16)24-21-13-20(22-15-23-21)17-8-6-10-19(12-17)25(26)27/h5-13,15H,3-4,14H2,1-2H3,(H,22,23,24) BAOFSPORUOMYDN-UHFFFAOYSA-N 50013596 CHEMBL3263803 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9870 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013596&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579931 242058313 CHEMBL3263803 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094818 CCOP(=O)(OCC)C(O)c1cccc(Nc2cc(ncn2)-c2cccc(c2)[N+]([O-])=O)c1 InChI=1S/C21H23N4O6P/c1-3-30-32(29,31-4-2)21(26)16-8-5-9-17(11-16)24-20-13-19(22-14-23-20)15-7-6-10-18(12-15)25(27)28/h5-14,21,26H,3-4H2,1-2H3,(H,22,23,24) RYYAOSBWLBJCKA-UHFFFAOYSA-N 50013597 CHEMBL3263804 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579932 242058314 CHEMBL3263804 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094819 CCOP(=O)(Cc1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1)OCC InChI=1S/C21H25N4O3P/c1-3-27-29(26,28-4-2)14-16-7-5-10-19(11-16)25-21-13-20(23-15-24-21)17-8-6-9-18(22)12-17/h5-13,15H,3-4,14,22H2,1-2H3,(H,23,24,25) UZYITJZOYUMOQZ-UHFFFAOYSA-N 50013598 CHEMBL3263805 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 332 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579970 242058315 CHEMBL3263805 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094820 CCOP(=O)(OCC)C(O)c1cccc(Nc2cc(ncn2)-c2cccc(N)c2)c1 InChI=1S/C21H25N4O4P/c1-3-28-30(27,29-4-2)21(26)16-8-6-10-18(12-16)25-20-13-19(23-14-24-20)15-7-5-9-17(22)11-15/h5-14,21,26H,3-4,22H2,1-2H3,(H,23,24,25) BFPCGNAMLGFTPV-UHFFFAOYSA-N 50013599 CHEMBL3263806 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1401 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013599&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579971 242058316 CHEMBL3263806 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094821 CCOP(=O)(Cc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1)OCC InChI=1S/C22H26N3O4P/c1-4-28-30(26,29-5-2)15-17-10-12-18(13-11-17)25-22-14-20(23-16-24-22)19-8-6-7-9-21(19)27-3/h6-14,16H,4-5,15H2,1-3H3,(H,23,24,25) IUKPUKAIZMZHJI-UHFFFAOYSA-N 50013600 CHEMBL3263807 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 490 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013600&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579972 103925697 CHEMBL3263807 ZINC29253651 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094822 CCOP(=O)(OCC)C(O)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1 InChI=1S/C22H26N3O5P/c1-4-29-31(27,30-5-2)22(26)16-10-12-17(13-11-16)25-21-14-19(23-15-24-21)18-8-6-7-9-20(18)28-3/h6-15,22,26H,4-5H2,1-3H3,(H,23,24,25) URSXGACDJHBFJN-UHFFFAOYSA-N 50013601 CHEMBL3264100 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 510 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013601&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86579973 103925698 CHEMBL3264100 ZINC36215670 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50094823 COc1ccccc1-c1cc(Nc2cccc(c2)S(N)(=O)=O)ncn1 InChI=1S/C17H16N4O3S/c1-24-16-8-3-2-7-14(16)15-10-17(20-11-19-15)21-12-5-4-6-13(9-12)25(18,22)23/h2-11H,1H3,(H2,18,22,23)(H,19,20,21) OEEGAHQEITTZMT-UHFFFAOYSA-N 50013602 CHEMBL3263772 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52 ChEMBL 10.1021/jm401742r 10.7270/Q28C9XRB 24742150 Németh, G; Greff, Z; Sipos, A; Varga, Z; Székely, R; Sebestyén, M; Jászay, Z; Béni, S; Nemes, Z; Pirat, JL; Volle, JN; Virieux, D; Gyuris, Á; Kelemenics, K; Ay, E; Minarovits, J; Szathmary, S; Kéri, G; Orfi, L Vichem Chemie Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013602&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57855560 103925699 CHEMBL3263772 ZINC04102215 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50098358 NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1 InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) CQNCHLJHIGRPDA-UHFFFAOYSA-N 50016163 CHEMBL3261514 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 749 ChEMBL 10.1016/j.ejmech.2014.04.013 10.7270/Q2NC62R8 24793884 Reichelt, A; Bailis, JM; Bartberger, MD; Yao, G; Shu, H; Kaller, MR; Allen, JG; Weidner, MF; Keegan, KS; Dao, JH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016163&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76072859 242041442 CHEMBL3261514 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50098359 COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20) VCUXVXLUOHDHKK-UHFFFAOYSA-N 50016166 CHEMBL3261517 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 729 ChEMBL 10.1016/j.ejmech.2014.04.013 10.7270/Q2NC62R8 24793884 Reichelt, A; Bailis, JM; Bartberger, MD; Yao, G; Shu, H; Kaller, MR; Allen, JG; Weidner, MF; Keegan, KS; Dao, JH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016166&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90643548 242041445 CHEMBL3261517 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50109447 COc1c(O)ccc2c1[nH]c1c3C=CC(C)(C)Oc3cc(O)c1c2=O InChI=1S/C19H17NO5/c1-19(2)7-6-9-13(25-19)8-12(22)14-15(9)20-16-10(17(14)23)4-5-11(21)18(16)24-3/h4-8,21-22H,1-3H3,(H,20,23) COUZVMMRGYONAQ-UHFFFAOYSA-N 50021616 CHEMBL3297832 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 820 ChEMBL 10.1021/np400856h 10.7270/Q2765GW6 24798019 Beniddir, MA; Le Borgne, E; Iorga, BI; Loaëc, N; Lozach, O; Meijer, L; Awang, K; Litaudon, M Institut de Chimie des Substances Naturelles http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021616&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86765296 103932314 CHEMBL3297832 ZINC26501673 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50109073 O=C(\C=C\c1cccc2c3CC(=O)Nc4ncccc4-c3[nH]c12)c1ccccc1 InChI=1S/C24H17N3O2/c28-20(15-6-2-1-3-7-15)12-11-16-8-4-9-17-19-14-21(29)26-24-18(10-5-13-25-24)23(19)27-22(16)17/h1-13,27H,14H2,(H,25,26,29)/b12-11+ KLKWSPDHDLEUBI-VAWYXSNFSA-N 50021391 CHEMBL3289596 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2014.06.020 10.7270/Q2WW7K8X 24973661 Maiwald, F; Benítez, D; Charquero, D; Dar, MA; Erdmann, H; Preu, L; Koch, O; Hölscher, C; Loaëc, N; Meijer, L; Comini, MA; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90645088 103932095 CHEMBL3289596 ZINC36189904 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50109075 O=C(Nc1ccccc1)\C=C\c1cccc2c3CC(=O)Nc4ncccc4-c3[nH]c12 InChI=1S/C24H18N4O2/c29-20(26-16-7-2-1-3-8-16)12-11-15-6-4-9-17-19-14-21(30)27-24-18(10-5-13-25-24)23(19)28-22(15)17/h1-13,28H,14H2,(H,26,29)(H,25,27,30)/b12-11+ XACYBDLLGKIZLC-VAWYXSNFSA-N 50021392 CHEMBL3289600 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2014.06.020 10.7270/Q2WW7K8X 24973661 Maiwald, F; Benítez, D; Charquero, D; Dar, MA; Erdmann, H; Preu, L; Koch, O; Hölscher, C; Loaëc, N; Meijer, L; Comini, MA; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021392&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90645089 103932096 CHEMBL3289600 ZINC29242497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50115827 Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23) GPSZYOIFQZPWEJ-UHFFFAOYSA-N 50277583 2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5::4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine::Aminopyrimidine, 9::CHEMBL482967::CYC-116 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 480 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277583&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6420138 104120139 CHEMBL482967 ZINC03950132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50177421 Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 InChI=1S/C12H10N4O/c13-12-14-5-4-8(16-12)7-6-15-9-2-1-3-10(17)11(7)9/h1-6,15,17H,(H2,13,14,16) SZOKTSDFOPVLFD-UHFFFAOYSA-N 10838 3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol::Meridianin A Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2400 ChEMBL 10.1016/j.bmc.2011.08.033 10.7270/Q25X29BF 21907583 Lebar, MD; Hahn, KN; Mutka, T; Maignan, P; McClintock, JB; Amsler, CD; van Olphen, A; Kyle, DE; Baker, BJ University of South Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10838&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 10421236 46511415 ZINC14589169 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50174729 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 950 ChEMBL 10.1021/jm100732t 10.7270/Q2B858GZ 21080703 Heathcote, DA; Patel, H; Kroll, SH; Hazel, P; Periyasamy, M; Alikian, M; Kanneganti, SK; Jogalekar, AS; Scheiper, B; Barbazanges, M; Blum, A; Brackow, J; Siwicka, A; Pace, RD; Fuchter, MJ; Snyder, JP; Liotta, DC; Freemont, PS; Aboagye, EO; Coombes, RC; Barrett, AG; Ali, S Imperial College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50174730 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 InChI=1S/C20H27N5O3/c1-13(2)15-10-22-25-19(21-9-14-6-4-3-5-7-14)8-18(24-20(15)25)23-16(11-26)17(28)12-27/h3-8,10,13,16-17,21,26-28H,9,11-12H2,1-2H3,(H,23,24)/t16-,17+/m0/s1 KRIWIRSMQRQYJG-DLBZAZTESA-N 50347388 CHEMBL1234833 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90 ChEMBL 10.1021/jm100732t 10.7270/Q2B858GZ 21080703 Heathcote, DA; Patel, H; Kroll, SH; Hazel, P; Periyasamy, M; Alikian, M; Kanneganti, SK; Jogalekar, AS; Scheiper, B; Barbazanges, M; Blum, A; Brackow, J; Siwicka, A; Pace, RD; Fuchter, MJ; Snyder, JP; Liotta, DC; Freemont, PS; Aboagye, EO; Coombes, RC; Barrett, AG; Ali, S Imperial College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347388&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search NS9 3NS9 25125014 136354074 CHEMBL1234833 ZINC58655676 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50198784 CN(C)CCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C InChI=1S/C25H33Cl2N5O3S/c1-25(2,3)19-15-16(22(36-19)29-24(35)28-18-8-6-7-17(26)21(18)27)23(34)32-10-9-20(33)31(13-14-32)12-11-30(4)5/h6-8,15H,9-14H2,1-5H3,(H2,28,29,35) SIUIQMQVKUUQQF-UHFFFAOYSA-N 50359359 CHEMBL1929238 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50359359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50359359&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search P7C 3P7C 53384644 136963383 CHEMBL1929238 ZINC72318122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50198818 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224208 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)ncc1C#N InChI=1S/C20H21N7O3S2/c1-13-18(31-20(22-2)24-13)17-14(11-21)12-23-19(26-17)25-15-3-5-16(6-4-15)32(28,29)27-7-9-30-10-8-27/h3-6,12H,7-10H2,1-2H3,(H,22,24)(H,23,25,26) KZKOIZXRAQJRPY-UHFFFAOYSA-N 50425007 CHEMBL2312186 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425007&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253465 164153882 CHEMBL2312186 ZINC95594238 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224210 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C16H15N7O2S2/c1-9-14(26-16(19-2)21-9)13-10(7-17)8-20-15(23-13)22-11-3-5-12(6-4-11)27(18,24)25/h3-6,8H,1-2H3,(H,19,21)(H2,18,24,25)(H,20,22,23) AEIHOULIOWEFLO-UHFFFAOYSA-N 50425006 CHEMBL2312187 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425006&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253324 164153881 CHEMBL2312187 ZINC95595183 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224211 CNc1nc(C)c(s1)-c1nc(Nc2cccc(O)c2)ncc1C#N InChI=1S/C16H14N6OS/c1-9-14(24-16(18-2)20-9)13-10(7-17)8-19-15(22-13)21-11-4-3-5-12(23)6-11/h3-6,8,23H,1-2H3,(H,18,20)(H,19,21,22) NYRVLHGVDPPWJS-UHFFFAOYSA-N 50425005 CHEMBL2312188 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425005&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T9N 4BCN,4BCJ 44253187 164153880 CHEMBL2312188 ZINC95596931 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224212 CNc1nc(C)c(s1)-c1nc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)ncc1C#N InChI=1S/C21H23N7O3S2/c1-13-4-5-16(10-17(13)33(29,30)28-6-8-31-9-7-28)26-20-24-12-15(11-22)18(27-20)19-14(2)25-21(23-3)32-19/h4-5,10,12H,6-9H2,1-3H3,(H,23,25)(H,24,26,27) SSEDQERECATUBR-UHFFFAOYSA-N 50425004 CHEMBL2312189 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425004&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44224280 164153879 CHEMBL2312189 ZINC43207877 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224219 Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15) AYZRKFOEZQBUEA-UHFFFAOYSA-N 12028 4-Arylazo-3,5-diamino-1H-pyrazole 31b::4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol::CAN508 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12028&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search F18 3TN8,3TNH,3TNW,2CLX 9859248 46512535 ZINC17782150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224220 OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cc(Cl)c(Cl)cc12 InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1 XHSQDZXAVJRBMX-DDHJBXDOSA-N 11324 (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol::5,6-Dichloro-1-.beta.-D-ribofuranosylbenzimidazole::5,6-dichloro-ribofuranosylbenzimidazole::CHEMBL375530::DRB Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11324&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RFZ 3MY1,3MY5,3H30 5894 46511870 CHEMBL375530 DB08473 5178 ZINC03873418 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50213308 CC(C)CC(=O)Nc1[nH]nc2c1CN(C(=O)C1CCN(C)CC1)C2(C)C InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25) HUXYBQXJVXOMKX-UHFFFAOYSA-N 50378657 CHEMBL1230607 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 138 ChEMBL 10.1016/j.bmc.2010.01.042 10.7270/Q21R6RG5 20153204 Brasca, MG; Albanese, C; Alzani, R; Amici, R; Avanzi, N; Ballinari, D; Bischoff, J; Borghi, D; Casale, E; Croci, V; Fiorentini, F; Isacchi, A; Mercurio, C; Nesi, M; Orsini, P; Pastori, W; Pesenti, E; Pevarello, P; Roussel, P; Varasi, M; Volpi, D; Vulpetti, A; Ciomei, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378657&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46191454 160857740 CHEMBL1230607 ZINC52509437 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224749 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1C#N InChI=1S/C21H24N8S/c1-14-19(30-21(23-2)26-14)18-15(12-22)13-25-20(28-18)27-16-5-3-6-17(11-16)29-9-4-7-24-8-10-29/h3,5-6,11,13,24H,4,7-10H2,1-2H3,(H,23,26)(H,25,27,28) BKOYUSKBPMSUBK-UHFFFAOYSA-N 50425008 CHEMBL2312185 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425008&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T3C 4BCP,4BCG 71300299 164153883 CHEMBL2312185 ZINC95597277 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224750 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)[N+]([O-])=O)ncc1C#N InChI=1S/C16H13N7O2S/c1-9-14(26-16(18-2)20-9)13-10(7-17)8-19-15(22-13)21-11-4-3-5-12(6-11)23(24)25/h3-6,8H,1-2H3,(H,18,20)(H,19,21,22) OOKAYBMMWNSBPA-UHFFFAOYSA-N 50425011 CHEMBL2312182 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425011&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253323 164153886 CHEMBL2312182 ZINC95596415 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224751 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1C#N InChI=1S/C16H15N7O2S2/c1-9-14(26-16(19-2)21-9)13-10(7-17)8-20-15(23-13)22-11-4-3-5-12(6-11)27(18,24)25/h3-6,8H,1-2H3,(H,19,21)(H2,18,24,25)(H,20,22,23) SGOFFNQMBSXTRU-UHFFFAOYSA-N 50425010 CHEMBL2312183 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425010&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T3E 4BCI,4BCK 44253325 164153885 CHEMBL2312183 ZINC95597472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224752 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)N2CCCNCC2)n1 InChI=1S/C20H25N7S/c1-14-18(28-20(21-2)24-14)17-7-9-23-19(26-17)25-15-5-3-6-16(13-15)27-11-4-8-22-10-12-27/h3,5-7,9,13,22H,4,8,10-12H2,1-2H3,(H,21,24)(H,23,25,26) BTDMLZGYAGONHW-UHFFFAOYSA-N 50431345 CHEMBL2348652 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431345&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561659 164160220 CHEMBL2348652 ZINC95603580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224753 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C16H13F3N6O2S/c1-20-15-24-12(8-16(17,18)19)13(28-15)11-5-6-21-14(23-11)22-9-3-2-4-10(7-9)25(26)27/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23) ZTSNAFZQMAUJCQ-UHFFFAOYSA-N 50431344 CHEMBL2348653 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 134 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431344&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562285 164160219 CHEMBL2348653 ZINC95603286 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224754 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1F InChI=1S/C20H24FN7S/c1-13-18(29-20(22-2)25-13)17-16(21)12-24-19(27-17)26-14-5-3-6-15(11-14)28-9-4-7-23-8-10-28/h3,5-6,11-12,23H,4,7-10H2,1-2H3,(H,22,25)(H,24,26,27) ZHXQLMCSTVATST-UHFFFAOYSA-N 50431347 CHEMBL2348650 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431347&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562168 164160222 CHEMBL2348650 ZINC95605858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224755 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCN(CC2)C(C)=O)ncc1C#N InChI=1S/C23H26N8OS/c1-15-21(33-23(25-3)27-15)20-17(13-24)14-26-22(29-20)28-18-6-4-7-19(12-18)31-9-5-8-30(10-11-31)16(2)32/h4,6-7,12,14H,5,8-11H2,1-3H3,(H,25,27)(H,26,28,29) DZHBFQMOLIUZMP-UHFFFAOYSA-N 50431346 CHEMBL2348651 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431346&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T6Q 4BCF,4BCO 70680234 164160221 CHEMBL2348651 ZINC95603671 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224756 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2cccc(O)c2)n1 InChI=1S/C16H14F3N5OS/c1-20-15-24-12(8-16(17,18)19)13(26-15)11-5-6-21-14(23-11)22-9-3-2-4-10(25)7-9/h2-7,25H,8H2,1H3,(H,20,24)(H,21,22,23) JCPWXGQBEYYLTQ-UHFFFAOYSA-N 50431343 CHEMBL2348654 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 245 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431343&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562286 164160218 CHEMBL2348654 ZINC95601131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224761 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1O InChI=1S/C15H16N6O3S2/c1-8-13(25-15(17-2)19-8)12-11(22)7-18-14(21-12)20-9-4-3-5-10(6-9)26(16,23)24/h3-7,22H,1-2H3,(H,17,19)(H2,16,23,24)(H,18,20,21) HVCCBYPTQRNASA-UHFFFAOYSA-N 50431361 CHEMBL2347596 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431361&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561914 164160236 CHEMBL2347596 ZINC95602872 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224763 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) GAIOPWBQKZMUNO-UHFFFAOYSA-N 50431360 CHEMBL2347597 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431360&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561915 164160235 CHEMBL2347597 ZINC95605236 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224759 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)[N+]([O-])=O)ncc1O InChI=1S/C15H14N6O3S/c1-8-13(25-15(16-2)18-8)12-11(22)7-17-14(20-12)19-9-4-3-5-10(6-9)21(23)24/h3-7,22H,1-2H3,(H,16,18)(H,17,19,20) XGOGJKVSHQHTDQ-UHFFFAOYSA-N 50431362 CHEMBL2347594 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 932 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431362&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561913 164160237 CHEMBL2347594 ZINC95604245 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224760 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C15H16N6O2S2/c1-9-13(24-15(17-2)19-9)12-6-7-18-14(21-12)20-10-4-3-5-11(8-10)25(16,22)23/h3-8H,1-2H3,(H,17,19)(H2,16,22,23)(H,18,20,21) OTPFZAVDWPCJLJ-UHFFFAOYSA-N 81430 CDK Inhibitor, 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81430&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11675224 131342004 ZINC38224817 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224846 CNc1nc(c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1)-c1ccccc1 InChI=1S/C20H16N6O2S/c1-21-20-25-17(13-6-3-2-4-7-13)18(29-20)16-10-11-22-19(24-16)23-14-8-5-9-15(12-14)26(27)28/h2-12H,1H3,(H,21,25)(H,22,23,24) CSSKMDOTUWJHLE-UHFFFAOYSA-N 50424999 CHEMBL2312193 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50424999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50424999&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562284 164153874 CHEMBL2312193 ZINC95593895 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224847 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C16H15F3N6O2S2/c1-21-15-25-12(8-16(17,18)19)13(28-15)11-5-6-22-14(24-11)23-9-3-2-4-10(7-9)29(20,26)27/h2-7H,8H2,1H3,(H,21,25)(H2,20,26,27)(H,22,23,24) LTPKYPDZFVTFOH-UHFFFAOYSA-N 50431341 CHEMBL2348841 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 156 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431341&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562394 164160216 CHEMBL2348841 ZINC95602434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224848 CNc1nc(c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1)C(F)(F)F InChI=1S/C15H13F3N6O2S2/c1-20-14-24-12(15(16,17)18)11(27-14)10-5-6-21-13(23-10)22-8-3-2-4-9(7-8)28(19,25)26/h2-7H,1H3,(H,20,24)(H2,19,25,26)(H,21,22,23) BXMBIVXDTXURDF-UHFFFAOYSA-N 50431340 CHEMBL2348842 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431340&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562395 164160215 CHEMBL2348842 ZINC95603317 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224850 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C15H14N6O2S/c1-9-13(24-15(16-2)18-9)12-6-7-17-14(20-12)19-10-4-3-5-11(8-10)21(22)23/h3-8H,1-2H3,(H,16,18)(H,17,19,20) AXAQVNRYNMCZCK-UHFFFAOYSA-N 50431363 CHEMBL46429 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431363&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6539296 164160238 CHEMBL46429 ZINC13559874 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224851 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C16H14F3N5OS/c1-20-15-24-12(8-16(17,18)19)13(26-15)11-6-7-21-14(23-11)22-9-2-4-10(25)5-3-9/h2-7,25H,8H2,1H3,(H,20,24)(H,21,22,23) JDGZTYYDQGRYGF-UHFFFAOYSA-N 50431342 CHEMBL2348840 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 278 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431342&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562393 164160217 CHEMBL2348840 ZINC95605594 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224870 CNc1ncc(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C14H14N6O2S2/c1-16-14-18-8-12(23-14)11-5-6-17-13(20-11)19-9-3-2-4-10(7-9)24(15,21)22/h2-8H,1H3,(H,16,18)(H2,15,21,22)(H,17,19,20) CDKRFBBXZQUTDX-UHFFFAOYSA-N 50431337 CHEMBL2348845 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431337&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562398 164160212 CHEMBL2348845 ZINC95605502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224871 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C17H18N6O2S2/c1-19-17-23-14(10-5-6-10)15(26-17)13-7-8-20-16(22-13)21-11-3-2-4-12(9-11)27(18,24)25/h2-4,7-10H,5-6H2,1H3,(H,19,23)(H2,18,24,25)(H,20,21,22) ASUFRYKYWHJUIO-UHFFFAOYSA-N 50431336 CHEMBL2348846 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431336&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562399 164160211 CHEMBL2348846 ZINC95601524 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224874 CNc1nc(c(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1)C(F)(F)F InChI=1S/C15H13F3N6O2S2/c1-20-14-24-12(15(16,17)18)11(27-14)10-6-7-21-13(23-10)22-8-2-4-9(5-3-8)28(19,25)26/h2-7H,1H3,(H,20,24)(H2,19,25,26)(H,21,22,23) FPHITTVVVWKENE-UHFFFAOYSA-N 50431339 CHEMBL2348843 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431339&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562396 164160214 CHEMBL2348843 ZINC95601088 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224877 CNc1ncc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C14H14N6O2S2/c1-16-14-18-8-12(23-14)11-6-7-17-13(20-11)19-9-2-4-10(5-3-9)24(15,21)22/h2-8H,1H3,(H,16,18)(H2,15,21,22)(H,17,19,20) BWONSNVPSAEXDY-UHFFFAOYSA-N 50431338 CHEMBL2348844 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431338&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562397 164160213 CHEMBL2348844 ZINC95603934 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224878 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C17H18N6O2S2/c1-19-17-23-14(10-2-3-10)15(26-17)13-8-9-20-16(22-13)21-11-4-6-12(7-5-11)27(18,24)25/h4-10H,2-3H2,1H3,(H,19,23)(H2,18,24,25)(H,20,21,22) GAFYDJGFHJBXQQ-UHFFFAOYSA-N 50431335 CHEMBL2348847 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431335&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562504 164160210 CHEMBL2348847 ZINC95605012 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224905 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2cccc(c2)N2CCCNCC2)n1 InChI=1S/C22H27N7S/c1-23-22-28-19(15-6-7-15)20(30-22)18-8-10-25-21(27-18)26-16-4-2-5-17(14-16)29-12-3-9-24-11-13-29/h2,4-5,8,10,14-15,24H,3,6-7,9,11-13H2,1H3,(H,23,28)(H,25,26,27) PHDVEAVKGNZPQH-UHFFFAOYSA-N 50431334 CHEMBL2348848 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562505 164160209 CHEMBL2348848 ZINC95605024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224927 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C22H24N8OS/c1-14-20(32-22(24-3)26-14)19-16(12-23)13-25-21(28-19)27-17-5-4-6-18(11-17)30-9-7-29(8-10-30)15(2)31/h4-6,11,13H,7-10H2,1-3H3,(H,24,26)(H,25,27,28) BGPUFSMDGGQOIE-UHFFFAOYSA-N 50431356 CHEMBL2348641 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431356&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562041 164160231 CHEMBL2348641 ZINC95603985 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224928 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1C#N InChI=1S/C20H22N8S/c1-13-18(29-20(22-2)25-13)17-14(11-21)12-24-19(27-17)26-15-4-3-5-16(10-15)28-8-6-23-7-9-28/h3-5,10,12,23H,6-9H2,1-2H3,(H,22,25)(H,24,26,27) HMCJMBDXHYZRRL-UHFFFAOYSA-N 50431355 CHEMBL2348642 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431355&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562042 164160230 CHEMBL2348642 ZINC95602636 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224930 CCCc1cnc(Nc2cccc(c2)S(N)(=O)=O)nc1-c1sc(NC)nc1C InChI=1S/C18H22N6O2S2/c1-4-6-12-10-21-17(23-13-7-5-8-14(9-13)28(19,25)26)24-15(12)16-11(2)22-18(20-3)27-16/h5,7-10H,4,6H2,1-3H3,(H,20,22)(H2,19,25,26)(H,21,23,24) METVKPPIUTYYDQ-UHFFFAOYSA-N 50431364 CHEMBL2348640 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431364&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561919 164160239 CHEMBL2348640 ZINC95603991 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224933 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCCC2)ncc1C#N InChI=1S/C21H23N7S/c1-14-19(29-21(23-2)25-14)18-15(12-22)13-24-20(27-18)26-16-7-6-8-17(11-16)28-9-4-3-5-10-28/h6-8,11,13H,3-5,9-10H2,1-2H3,(H,23,25)(H,24,26,27) BCKLVLDQAAHMQR-UHFFFAOYSA-N 50431352 CHEMBL2348645 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431352&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562045 164160227 CHEMBL2348645 ZINC95605230 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224935 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1F InChI=1S/C21H24FN7OS/c1-13-19(31-21(23-3)25-13)18-17(22)12-24-20(27-18)26-15-5-4-6-16(11-15)29-9-7-28(8-10-29)14(2)30/h4-6,11-12H,7-10H2,1-3H3,(H,23,25)(H,24,26,27) MCFCYLCLAYXQIZ-UHFFFAOYSA-N 50431351 CHEMBL2348646 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431351&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562046 164160226 CHEMBL2348646 ZINC95604947 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224936 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C22H24N8OS/c1-14-20(32-22(24-3)26-14)19-16(12-23)13-25-21(28-19)27-17-4-6-18(7-5-17)30-10-8-29(9-11-30)15(2)31/h4-7,13H,8-11H2,1-3H3,(H,24,26)(H,25,27,28) CLHJUHZESGJESB-UHFFFAOYSA-N 50431354 CHEMBL2348643 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431354&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562043 164160229 CHEMBL2348643 ZINC95603258 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224938 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)N2CCNCC2)ncc1C#N InChI=1S/C20H22N8S/c1-13-18(29-20(22-2)25-13)17-14(11-21)12-24-19(27-17)26-15-3-5-16(6-4-15)28-9-7-23-8-10-28/h3-6,12,23H,7-10H2,1-2H3,(H,22,25)(H,24,26,27) WMMICHSZLWUPOT-UHFFFAOYSA-N 50431353 CHEMBL2348644 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431353&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562044 164160228 CHEMBL2348644 ZINC95602425 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224953 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1Cl InChI=1S/C19H22ClN7S/c1-12-17(28-19(21-2)24-12)16-15(20)11-23-18(26-16)25-13-4-3-5-14(10-13)27-8-6-22-7-9-27/h3-5,10-11,22H,6-9H2,1-2H3,(H,21,24)(H,23,25,26) YZRRSIPTHDIILM-UHFFFAOYSA-N 50431348 CHEMBL2348649 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431348&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562167 164160223 CHEMBL2348649 ZINC95602151 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224956 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1F InChI=1S/C19H22FN7S/c1-12-17(28-19(21-2)24-12)16-15(20)11-23-18(26-16)25-13-4-3-5-14(10-13)27-8-6-22-7-9-27/h3-5,10-11,22H,6-9H2,1-2H3,(H,21,24)(H,23,25,26) CKIFWVSQRJHDKI-UHFFFAOYSA-N 50431350 CHEMBL2348647 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431350&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562165 164160225 CHEMBL2348647 ZINC95602927 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224957 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCOCC2)ncc1F InChI=1S/C19H21FN6OS/c1-12-17(28-19(21-2)23-12)16-15(20)11-22-18(25-16)24-13-4-3-5-14(10-13)26-6-8-27-9-7-26/h3-5,10-11H,6-9H2,1-2H3,(H,21,23)(H,22,24,25) HXZXJLLRGFULES-UHFFFAOYSA-N 50431349 CHEMBL2348648 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431349&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562166 164160224 CHEMBL2348648 ZINC95602450 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224965 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1C InChI=1S/C16H18N6O2S2/c1-9-8-19-15(21-11-5-4-6-12(7-11)26(17,23)24)22-13(9)14-10(2)20-16(18-3)25-14/h4-8H,1-3H3,(H,18,20)(H2,17,23,24)(H,19,21,22) LVJZZDNNQXAXPX-UHFFFAOYSA-N 50431358 CHEMBL2348638 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431358&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561917 164160233 CHEMBL2348638 ZINC95601753 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224966 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 800 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224967 CCc1cnc(Nc2cccc(c2)S(N)(=O)=O)nc1-c1sc(NC)nc1C InChI=1S/C17H20N6O2S2/c1-4-11-9-20-16(22-12-6-5-7-13(8-12)27(18,24)25)23-14(11)15-10(2)21-17(19-3)26-15/h5-9H,4H2,1-3H3,(H,19,21)(H2,18,24,25)(H,20,22,23) IMJBYEMGFQYCFQ-UHFFFAOYSA-N 50431357 CHEMBL2348639 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431357&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561918 164160232 CHEMBL2348639 ZINC95604147 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224968 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1Cl InChI=1S/C15H15ClN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) ZOLPUEOXQAILTM-UHFFFAOYSA-N 50431359 CHEMBL2348637 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431359&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71561916 164160234 CHEMBL2348637 ZINC95605850 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224119 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224124 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)[N+]([O-])=O)ncc1C#N InChI=1S/C16H13N7O2S/c1-9-14(26-16(18-2)20-9)13-10(7-17)8-19-15(22-13)21-11-4-3-5-12(6-11)23(24)25/h3-6,8H,1-2H3,(H,18,20)(H,19,21,22) OOKAYBMMWNSBPA-UHFFFAOYSA-N 50425011 CHEMBL2312182 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425011&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253323 164153886 CHEMBL2312182 ZINC95596415 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224125 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1C#N InChI=1S/C16H15N7O2S2/c1-9-14(26-16(19-2)21-9)13-10(7-17)8-20-15(23-13)22-11-4-3-5-12(6-11)27(18,24)25/h3-6,8H,1-2H3,(H,19,21)(H2,18,24,25)(H,20,22,23) SGOFFNQMBSXTRU-UHFFFAOYSA-N 50425010 CHEMBL2312183 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425010&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T3E 4BCI,4BCK 44253325 164153885 CHEMBL2312183 ZINC95597472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224126 CNc1nc(C)c(s1)-c1nc(Nc2cccc(CC(=O)N3CCCNCC3)c2)ncc1C#N InChI=1S/C23H26N8OS/c1-15-21(33-23(25-2)28-15)20-17(13-24)14-27-22(30-20)29-18-6-3-5-16(11-18)12-19(32)31-9-4-7-26-8-10-31/h3,5-6,11,14,26H,4,7-10,12H2,1-2H3,(H,25,28)(H,27,29,30) UBKCVLVAEFXGTJ-UHFFFAOYSA-N 50425009 CHEMBL2312184 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425009&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71720363 164153884 CHEMBL2312184 ZINC95593626 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224128 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1C#N InChI=1S/C21H24N8S/c1-14-19(30-21(23-2)26-14)18-15(12-22)13-25-20(28-18)27-16-5-3-6-17(11-16)29-9-4-7-24-8-10-29/h3,5-6,11,13,24H,4,7-10H2,1-2H3,(H,23,26)(H,25,27,28) BKOYUSKBPMSUBK-UHFFFAOYSA-N 50425008 CHEMBL2312185 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425008&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T3C 4BCP,4BCG 71300299 164153883 CHEMBL2312185 ZINC95597277 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224200 CNc1nc(C)c(s1)-c1nc(Nc2ccc(O)cc2)ncc1C#N InChI=1S/C16H14N6OS/c1-9-14(24-16(18-2)20-9)13-10(7-17)8-19-15(22-13)21-11-3-5-12(23)6-4-11/h3-6,8,23H,1-2H3,(H,18,20)(H,19,21,22) YVRLFXOPNVVCQT-UHFFFAOYSA-N 50425003 CHEMBL2312190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425003&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253186 164153878 CHEMBL2312190 ZINC95593919 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224201 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCOCC2)ncc1C#N InChI=1S/C21H21N7O2S/c1-13-18(31-21(23-2)25-13)17-15(11-22)12-24-20(27-17)26-16-5-3-4-14(10-16)19(29)28-6-8-30-9-7-28/h3-5,10,12H,6-9H2,1-2H3,(H,23,25)(H,24,26,27) UFUGKBGESCNADR-UHFFFAOYSA-N 50425002 CHEMBL2312191 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425002&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search TJF 4BCQ 44253188 164153877 CHEMBL2312191 ZINC95593936 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224202 CNc1nc(c(s1)-c1ccnc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)n1)-c1ccccc1 InChI=1S/C25H26N6O3S2/c1-17-8-9-19(16-21(17)36(32,33)31-12-14-34-15-13-31)28-24-27-11-10-20(29-24)23-22(30-25(26-2)35-23)18-6-4-3-5-7-18/h3-11,16H,12-15H2,1-2H3,(H,26,30)(H,27,28,29) QRTGRZYUIZLJET-UHFFFAOYSA-N 50425000 CHEMBL2312192 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6185 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425000&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562507 164153875 CHEMBL2312192 ZINC95595571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224203 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224204 CNc1nc(c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1)-c1ccccc1 InChI=1S/C20H16N6O2S/c1-21-20-25-17(13-6-3-2-4-7-13)18(29-20)16-10-11-22-19(24-16)23-14-8-5-9-15(12-14)26(27)28/h2-12H,1H3,(H,21,25)(H,22,23,24) CSSKMDOTUWJHLE-UHFFFAOYSA-N 50424999 CHEMBL2312193 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9835 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50424999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50424999&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71562284 164153874 CHEMBL2312193 ZINC95593895 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224205 CC[C@@H](CO)Nc1nc(Cc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C24H28N6O/c1-4-19(14-31)27-24-28-21(22-23(29-24)30(15-26-22)16(2)3)13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12,15-16,19,31H,4,13-14H2,1-3H3,(H,27,28,29)/t19-/m0/s1 WUTFIZGMCPBYJH-IBGZPJMESA-N 50425001 CHEMBL2312194 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425001&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71719747 164153876 CHEMBL2312194 ZINC95595211 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50224207 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 790 ChEMBL 10.1021/jm301495v 10.7270/Q28G8N18 23252711 Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50231001 NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1 InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20) VOQXQYXTZZHYBF-UHFFFAOYSA-N 50329427 5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide::CHEMBL1270230::US9670191, U1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 394 ChEMBL 10.1021/jm100504d 10.7270/Q24T6JM3 20873740 Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tato, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329427&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24809764 123108542 CHEMBL1270230 ZINC64528488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408577 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(F)ccc1C InChI=1S/C15H13ClFN5O2S/c1-10-3-4-12(17)7-13(10)25(23,24)21(2)18-8-11-9-19-22-6-5-14(16)20-15(11)22/h3-9H,1-2H3/b18-8+ FXIWPTMYZSNELK-QGMBQPNBSA-N 50118368 CHEMBL3612499 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118368&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188267 319565731 CHEMBL3612499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408578 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)S(C)(=O)=O InChI=1S/C16H16ClN5O4S2/c1-11-4-5-13(27(3,23)24)8-14(11)28(25,26)21(2)18-9-12-10-19-22-7-6-15(17)20-16(12)22/h4-10H,1-3H3/b18-9+ KLRSZDNRABGRPL-GIJQJNRQSA-N 50118369 CHEMBL3612500 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1064 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118369&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188268 319565732 CHEMBL3612500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408579 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1Cl)[N+]([O-])=O InChI=1S/C14H10Cl2N6O4S/c1-20(17-7-9-8-18-21-5-4-13(16)19-14(9)21)27(25,26)12-6-10(22(23)24)2-3-11(12)15/h2-8H,1H3/b17-7+ BQFWZWNBYBXNGJ-REZTVBANSA-N 50118370 CHEMBL3612501 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118370&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188269 104011688 CHEMBL3612501 ZINC13491211 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408580 COc1ccc(cc1S(=O)(=O)N(C)\N=C\c1cnn2ccc(Cl)nc12)[N+]([O-])=O InChI=1S/C15H13ClN6O5S/c1-20(17-8-10-9-18-21-6-5-14(16)19-15(10)21)28(25,26)13-7-11(22(23)24)3-4-12(13)27-2/h3-9H,1-2H3/b17-8+ HCEZBQKGULOZLN-CAOOACKPSA-N 50118371 CHEMBL3612502 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 174 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118371&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188270 104011689 CHEMBL3612502 ZINC02573996 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408581 CN(\N=C\c1cnn2ccc(C)nc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H16N6O4S/c1-11-4-5-14(22(23)24)8-15(11)27(25,26)20(3)17-9-13-10-18-21-7-6-12(2)19-16(13)21/h4-10H,1-3H3/b17-9+ QZIMFEZMFNJUKH-RQZCQDPDSA-N 50118224 CHEMBL3612503 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 379 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118224&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188271 104011561 CHEMBL3612503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408582 COc1ccc(cc1OC)-c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2n1 InChI=1S/C23H22N6O6S/c1-15-5-7-18(29(30)31)12-22(15)36(32,33)27(2)24-13-17-14-25-28-10-9-19(26-23(17)28)16-6-8-20(34-3)21(11-16)35-4/h5-14H,1-4H3/b24-13+ UCRFEDKYGLHWFM-ZMOGYAJESA-N 50118236 CHEMBL3612504 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118236&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188272 104011573 CHEMBL3612504 ZINC08035172 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408583 CN(\N=C\c1cnn2ccc(nc12)-c1cccnc1)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C20H17N7O4S/c1-14-5-6-17(27(28)29)10-19(14)32(30,31)25(2)22-12-16-13-23-26-9-7-18(24-20(16)26)15-4-3-8-21-11-15/h3-13H,1-2H3/b22-12+ ZRKHDIABAALLSW-WSDLNYQXSA-N 50118241 CHEMBL3612505 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 209 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118241&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188273 104011578 CHEMBL3612505 ZINC27325228 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408584 COc1ccc(cn1)-c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2n1 InChI=1S/C21H19N7O5S/c1-14-4-6-17(28(29)30)10-19(14)34(31,32)26(2)23-12-16-13-24-27-9-8-18(25-21(16)27)15-5-7-20(33-3)22-11-15/h4-13H,1-3H3/b23-12+ JWTRWPDHWSAJPG-FSJBWODESA-N 50118259 CHEMBL3612506 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118259&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188274 104011596 CHEMBL3612506 ZINC01494381 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408585 CN(\N=C\c1cnn2ccc(nc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H13N7O4S/c1-11-3-4-14(23(24)25)7-15(11)28(26,27)21(2)18-9-12-10-19-22-6-5-13(8-17)20-16(12)22/h3-7,9-10H,1-2H3/b18-9+ NAYMGHBSMQSCDC-GIJQJNRQSA-N 50118334 CHEMBL3612507 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188275 104011671 CHEMBL3612507 ZINC27330536 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408586 COc1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2n1 InChI=1S/C16H16N6O5S/c1-11-4-5-13(22(23)24)8-14(11)28(25,26)20(2)17-9-12-10-18-21-7-6-15(27-3)19-16(12)21/h4-10H,1-3H3/b17-9+ AYLQSRFNFBZNQA-RQZCQDPDSA-N 50118372 CHEMBL3612508 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1165 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118372&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188276 104011690 CHEMBL3612508 ZINC13491208 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408587 CN(C)c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2n1 InChI=1S/C17H19N7O4S/c1-12-5-6-14(24(25)26)9-15(12)29(27,28)22(4)18-10-13-11-19-23-8-7-16(21(2)3)20-17(13)23/h5-11H,1-4H3/b18-10+ GYCFMPYWCHHTMW-VCHYOVAHSA-N 50118373 CHEMBL3612509 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2518 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118373&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188277 104011691 CHEMBL3612509 ZINC00950325 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408588 CN(\N=C\c1cnn2ccc(nc12)N1CCOCC1)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C19H21N7O5S/c1-14-3-4-16(26(27)28)11-17(14)32(29,30)23(2)20-12-15-13-21-25-6-5-18(22-19(15)25)24-7-9-31-10-8-24/h3-6,11-13H,7-10H2,1-2H3/b20-12+ ZDYBKZVALORVSI-UDWIEESQSA-N 50118374 CHEMBL3612510 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6555 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118374&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188278 104011692 CHEMBL3612510 ZINC13491188 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408589 Cc1ccc(cc1S(=O)(=O)NCCc1cnn2ccc(Cl)nc12)[N+]([O-])=O InChI=1S/C15H14ClN5O4S/c1-10-2-3-12(21(22)23)8-13(10)26(24,25)18-6-4-11-9-17-20-7-5-14(16)19-15(11)20/h2-3,5,7-9,18H,4,6H2,1H3 FAWULGGSSGGIAH-UHFFFAOYSA-N 50118375 CHEMBL3612511 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1144 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118375&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188279 104011693 CHEMBL3612511 ZINC13491201 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408590 CN(CCc1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H16ClN5O4S/c1-11-3-4-13(22(23)24)9-14(11)27(25,26)20(2)7-5-12-10-18-21-8-6-15(17)19-16(12)21/h3-4,6,8-10H,5,7H2,1-2H3 TZRFJDYUNMZHNZ-UHFFFAOYSA-N 50118376 CHEMBL3612512 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 265 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118376&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188280 104011694 CHEMBL3612512 ZINC13491194 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408591 CN(CCc1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C#N InChI=1S/C17H16ClN5O2S/c1-12-3-4-13(10-19)9-15(12)26(24,25)22(2)7-5-14-11-20-23-8-6-16(18)21-17(14)23/h3-4,6,8-9,11H,5,7H2,1-2H3 LAZZFPCNZBTRIQ-UHFFFAOYSA-N 50118344 CHEMBL3612513 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 203 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118344&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188281 104011681 CHEMBL3612513 ZINC13491161 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408592 Cc1ccc(cc1S(=O)(=O)n1cc(cn1)-c1cnn2ccc(Cl)nc12)[N+]([O-])=O InChI=1S/C16H11ClN6O4S/c1-10-2-3-12(23(24)25)6-14(10)28(26,27)22-9-11(7-19-22)13-8-18-21-5-4-15(17)20-16(13)21/h2-9H,1H3 OQOSJDFXPZMLPT-UHFFFAOYSA-N 50118345 CHEMBL3612514 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118345&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188282 319565714 CHEMBL3612514 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408593 Cc1ccc(cc1S(=O)(=O)n1ccc(n1)-c1cnn2ccc(Cl)nc12)[N+]([O-])=O InChI=1S/C16H11ClN6O4S/c1-10-2-3-11(23(24)25)8-14(10)28(26,27)22-7-4-13(20-22)12-9-18-21-6-5-15(17)19-16(12)21/h2-9H,1H3 RIXVIJBWVAOGAZ-UHFFFAOYSA-N 50118377 CHEMBL3612515 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118377&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188283 104011695 CHEMBL3612515 ZINC13491214 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408594 Cc1ccc(cc1S(=O)(=O)n1ccc(c1)-c1cnn2ccc(Cl)nc12)[N+]([O-])=O InChI=1S/C17H12ClN5O4S/c1-11-2-3-13(23(24)25)8-15(11)28(26,27)21-6-4-12(10-21)14-9-19-22-7-5-16(18)20-17(14)22/h2-10H,1H3 YIMGMFZUFRVXJG-UHFFFAOYSA-N 50118378 CHEMBL3612622 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118378&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188365 104011696 CHEMBL3612622 ZINC13491187 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408644 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C15H13ClN6O4S/c1-10-3-4-12(22(23)24)7-13(10)27(25,26)20(2)17-8-11-9-18-21-6-5-14(16)19-15(11)21/h3-9H,1-2H3/b17-8+ QATNWRWOYYFNQO-CAOOACKPSA-N 50118346 CHEMBL3612482 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118346&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188249 319565715 CHEMBL3612482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408646 CN(\N=C\c1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+ QTHCAAFKVUWAFI-DJKKODMXSA-N 25036 CHEMBL393525::N'-[(1E)-{6-bromoimidazo[1,2-a]pyridin-3-yl}methylidene]-N,2-dimethyl-5-nitrobenzene-1-sulfonohydrazide::PIK-75, 1::US10981896, Compound PIK75::imidazopyridine derivative, 8c Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.4 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25036&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search F4N 6GN1 10275789 56374180 CHEMBL393525 ZINC28652818 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408647 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccccc1 InChI=1S/C14H12ClN5O2S/c1-19(23(21,22)12-5-3-2-4-6-12)16-9-11-10-17-20-8-7-13(15)18-14(11)20/h2-10H,1H3/b16-9+ GGBHZIZDAKPCPO-CXUHLZMHSA-N 50118347 CHEMBL3612483 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118347&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188250 319565716 CHEMBL3612483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408648 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccccc1C InChI=1S/C15H14ClN5O2S/c1-11-5-3-4-6-13(11)24(22,23)20(2)17-9-12-10-18-21-8-7-14(16)19-15(12)21/h3-10H,1-2H3/b17-9+ MVCPWLSPXUGHMG-RQZCQDPDSA-N 50118350 CHEMBL3612484 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118350&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188251 319565717 CHEMBL3612484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408649 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(c1)[N+]([O-])=O InChI=1S/C14H11ClN6O4S/c1-19(26(24,25)12-4-2-3-11(7-12)21(22)23)16-8-10-9-17-20-6-5-13(15)18-14(10)20/h2-9H,1H3/b16-8+ MMJRDYPVGDJVNB-LZYBPNLTSA-N 50118352 CHEMBL3612485 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 291 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118352&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188252 319565718 CHEMBL3612485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408650 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(C)c1 InChI=1S/C15H14ClN5O2S/c1-11-4-3-5-13(8-11)24(22,23)20(2)17-9-12-10-18-21-7-6-14(16)19-15(12)21/h3-10H,1-2H3/b17-9+ OPFFMYGRWXUDIA-RQZCQDPDSA-N 50118353 CHEMBL3612486 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118353&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188253 319565719 CHEMBL3612486 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408651 COc1cccc(c1)S(=O)(=O)N(C)\N=C\c1cnn2ccc(Cl)nc12 InChI=1S/C15H14ClN5O3S/c1-20(25(22,23)13-5-3-4-12(8-13)24-2)17-9-11-10-18-21-7-6-14(16)19-15(11)21/h3-10H,1-2H3/b17-9+ ZNQHETPKCVAICQ-RQZCQDPDSA-N 50118354 CHEMBL3612487 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118354&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188254 319565720 CHEMBL3612487 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408652 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(OC(F)(F)F)c1 InChI=1S/C15H11ClF3N5O3S/c1-23(20-8-10-9-21-24-6-5-13(16)22-14(10)24)28(25,26)12-4-2-3-11(7-12)27-15(17,18)19/h2-9H,1H3/b20-8+ OYSNJOXPTBUMBO-DNTJNYDQSA-N 50118356 CHEMBL3612488 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118356&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188255 319565721 CHEMBL3612488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408653 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(c1)C#N InChI=1S/C15H11ClN6O2S/c1-21(25(23,24)13-4-2-3-11(7-13)8-17)18-9-12-10-19-22-6-5-14(16)20-15(12)22/h2-7,9-10H,1H3/b18-9+ SNTZKZOXOUODGP-GIJQJNRQSA-N 50118357 CHEMBL3612489 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 201 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118357&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188256 319565722 CHEMBL3612489 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408654 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(F)c1 InChI=1S/C14H11ClFN5O2S/c1-20(24(22,23)12-4-2-3-11(16)7-12)17-8-10-9-18-21-6-5-13(15)19-14(10)21/h2-9H,1H3/b17-8+ XSGJTQUYIHJXDM-CAOOACKPSA-N 50118358 CHEMBL3612490 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118358&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188257 319565723 CHEMBL3612490 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408655 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O InChI=1S/C14H11ClN6O4S/c1-19(26(24,25)12-4-2-11(3-5-12)21(22)23)16-8-10-9-17-20-7-6-13(15)18-14(10)20/h2-9H,1H3/b16-8+ OXBZVQIFYTWYEI-LZYBPNLTSA-N 50118361 CHEMBL3612491 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118361&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188258 319565724 CHEMBL3612491 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408656 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C14H11ClFN5O2S/c1-20(24(22,23)12-4-2-11(16)3-5-12)17-8-10-9-18-21-7-6-13(15)19-14(10)21/h2-9H,1H3/b17-8+ OPDRBXSFNAPNDV-CAOOACKPSA-N 50118362 CHEMBL3612492 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118362&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188259 319565725 CHEMBL3612492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408657 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc(F)c(F)c1 InChI=1S/C14H10ClF2N5O2S/c1-21(25(23,24)10-2-3-11(16)12(17)6-10)18-7-9-8-19-22-5-4-13(15)20-14(9)22/h2-8H,1H3/b18-7+ GYAPNLNBDIIMEC-CNHKJKLMSA-N 50118363 CHEMBL3612493 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118363&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188260 319565726 CHEMBL3612493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408658 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccnc1 InChI=1S/C13H11ClN6O2S/c1-19(23(21,22)11-3-2-5-15-9-11)16-7-10-8-17-20-6-4-12(14)18-13(10)20/h2-9H,1H3/b16-7+ TXBODTAZBTZNAK-FRKPEAEDSA-N 50118364 CHEMBL3612494 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118364&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188261 319565727 CHEMBL3612494 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408659 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc[n+]([O-])c1 InChI=1S/C13H11ClN6O3S/c1-18(24(22,23)11-3-2-5-19(21)9-11)15-7-10-8-16-20-6-4-12(14)17-13(10)20/h2-9H,1H3/b15-7+ MCUOKEDQZHNAMS-VIZOYTHASA-N 50118365 CHEMBL3612495 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118365&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188262 319565728 CHEMBL3612495 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408660 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(Br)ccc1C InChI=1S/C15H13BrClN5O2S/c1-10-3-4-12(16)7-13(10)25(23,24)21(2)18-8-11-9-19-22-6-5-14(17)20-15(11)22/h3-9H,1-2H3/b18-8+ GIHANMLHNUCTLJ-QGMBQPNBSA-N 50118366 CHEMBL3612496 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1960 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118366&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188263 319565729 CHEMBL3612496 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408661 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C(O)=O InChI=1S/C16H14ClN5O4S/c1-10-3-4-11(16(23)24)7-13(10)27(25,26)21(2)18-8-12-9-19-22-6-5-14(17)20-15(12)22/h3-9H,1-2H3,(H,23,24)/b18-8+ RBFTYVKFYBZVGB-QGMBQPNBSA-N 50118210 CHEMBL3612497 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188264 104011547 CHEMBL3612497 ZINC13491035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408662 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C(N)=O InChI=1S/C16H15ClN6O3S/c1-10-3-4-11(15(18)24)7-13(10)27(25,26)22(2)19-8-12-9-20-23-6-5-14(17)21-16(12)23/h3-9H,1-2H3,(H2,18,24)/b19-8+ FGOFGEICLGDKQL-UFWORHAWSA-N 50118367 CHEMBL3612072 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118367&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188265 319565730 CHEMBL3612072 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50408663 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C#N InChI=1S/C16H13ClN6O2S/c1-11-3-4-12(8-18)7-14(11)26(24,25)22(2)19-9-13-10-20-23-6-5-15(17)21-16(13)23/h3-7,9-10H,1-2H3/b19-9+ AYCKASQUVBKOMD-DJKKODMXSA-N 50118212 CHEMBL3612498 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122188266 104011549 CHEMBL3612498 ZINC87515504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50441679 CN1CCN(CC1)C(=O)c1cccc(Nc2ncc(F)c(Nc3ccc(F)cc3)n2)c1 InChI=1S/C22H22F2N6O/c1-29-9-11-30(12-10-29)21(31)15-3-2-4-18(13-15)27-22-25-14-19(24)20(28-22)26-17-7-5-16(23)6-8-17/h2-8,13-14H,9-12H2,1H3,(H2,25,26,27,28) KHIUERHSMDLIPH-UHFFFAOYSA-N 50134091 CHEMBL3735432 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11300 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134091&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127037492 336951476 CHEMBL3735432 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50441709 CN1CCC(CC1)C(=O)Nc1cccc(Nc2ncc(F)c(Nc3ccc(F)cc3)n2)c1 InChI=1S/C23H24F2N6O/c1-31-11-9-15(10-12-31)22(32)28-18-3-2-4-19(13-18)29-23-26-14-20(25)21(30-23)27-17-7-5-16(24)6-8-17/h2-8,13-15H,9-12H2,1H3,(H,28,32)(H2,26,27,29,30) HCYJZHFDACGFQX-UHFFFAOYSA-N 50134088 CHEMBL3735231 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2450 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134088&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127035031 336951473 CHEMBL3735231 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50441712 Fc1cnc(Nc2cccc(c2)N2CCOCC2)nc1Nc1c(F)cccc1F InChI=1S/C20H18F3N5O/c21-15-5-2-6-16(22)18(15)26-19-17(23)12-24-20(27-19)25-13-3-1-4-14(11-13)28-7-9-29-10-8-28/h1-6,11-12H,7-10H2,(H2,24,25,26,27) ZNQWJLREBSRVBU-UHFFFAOYSA-N 50133899 CHEMBL3734879 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 330 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50133899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50133899&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127034835 336951470 CHEMBL3734879 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434577 C[C@H]1CCc2c(C1)sc1ncnc(Nc3ccc(F)c(Cl)c3)c21 InChI=1S/C17H15ClFN3S/c1-9-2-4-11-14(6-9)23-17-15(11)16(20-8-21-17)22-10-3-5-13(19)12(18)7-10/h3,5,7-9H,2,4,6H2,1H3,(H,20,21,22)/t9-/m0/s1 CDJDNJYXUJBYJD-VIFPVBQESA-N 50130708 CHEMBL3632735 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130708&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 725327 321903165 CHEMBL3632735 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434578 Ic1ccc(Nc2ncnc3[nH]ncc23)cc1 InChI=1S/C11H8IN5/c12-7-1-3-8(4-2-7)16-10-9-5-15-17-11(9)14-6-13-10/h1-6H,(H2,13,14,15,16,17) QSDMHOAEIDKWQL-UHFFFAOYSA-N 50130709 CHEMBL3632736 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7873 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130709&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 879999 321903166 CHEMBL3632736 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434579 CCOC(=O)c1sc2ncnc(Nc3ccc(F)cc3)c2c1C InChI=1S/C16H14FN3O2S/c1-3-22-16(21)13-9(2)12-14(18-8-19-15(12)23-13)20-11-6-4-10(17)5-7-11/h4-8H,3H2,1-2H3,(H,18,19,20) DGZVFKBKGVKNKD-UHFFFAOYSA-N 50067326 CHEMBL3237084 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067326&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 709073 313071815 CHEMBL3237084 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434580 Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) UQPMANVRZYYQMD-UHFFFAOYSA-N 50130693 CGP-57380::CHEMBL1240885 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130693&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11644425 104022005 CHEMBL1240885 ZINC26969297 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434581 COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22) OGNWKFYJHNZTNC-UHFFFAOYSA-N 98036 US8486953, 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=98036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=98036&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46182043 164039280 ZINC96167852 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434582 CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 InChI=1S/C17H16FN3O3S/c1-8(2)24-12-6-10(18)4-5-11(12)21-15-13-9(3)14(17(22)23)25-16(13)20-7-19-15/h4-8H,1-3H3,(H,22,23)(H,19,20,21) CRQZRBXFLRRAIQ-UHFFFAOYSA-N 50130702 CHEMBL3632742 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130702&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46182661 321903159 CHEMBL3632742 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434583 CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 InChI=1S/C17H17FN4O2S/c1-8(2)24-12-6-10(18)4-5-11(12)22-16-13-9(3)14(15(19)23)25-17(13)21-7-20-16/h4-8H,1-3H3,(H2,19,23)(H,20,21,22) SKMYKZYXPMRFNN-UHFFFAOYSA-N 50130703 CHEMBL3632743 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130703&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122194697 321903160 CHEMBL3632743 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434584 CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C InChI=1S/C18H19FN4O2S/c1-9(2)25-13-7-11(19)5-6-12(13)23-16-14-10(3)15(17(24)20-4)26-18(14)22-8-21-16/h5-9H,1-4H3,(H,20,24)(H,21,22,23) ZGXLPGBXVQLLJW-UHFFFAOYSA-N 50130704 CHEMBL3632744 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130704&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122194698 321903161 CHEMBL3632744 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434585 CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C InChI=1S/C19H21FN4O2S/c1-5-21-18(25)16-11(4)15-17(22-9-23-19(15)27-16)24-13-7-6-12(20)8-14(13)26-10(2)3/h6-10H,5H2,1-4H3,(H,21,25)(H,22,23,24) QVHDOESZFDSEKS-UHFFFAOYSA-N 50130705 CHEMBL3632745 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130705&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122194699 321903162 CHEMBL3632745 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434586 COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C InChI=1S/C20H23FN4O3S/c1-11(2)28-15-9-13(21)5-6-14(15)25-18-16-12(3)17(19(26)22-7-8-27-4)29-20(16)24-10-23-18/h5-6,9-11H,7-8H2,1-4H3,(H,22,26)(H,23,24,25) GOGWEKLFSKGXQA-UHFFFAOYSA-N 50130706 CHEMBL3632746 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130706&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122194700 321903163 CHEMBL3632746 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50434587 COCCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C InChI=1S/C21H25FN4O3S/c1-12(2)29-16-10-14(22)6-7-15(16)26-19-17-13(3)18(30-21(17)25-11-24-19)20(27)23-8-5-9-28-4/h6-7,10-12H,5,8-9H2,1-4H3,(H,23,27)(H,24,25,26) RYUUMGNHANZHLX-UHFFFAOYSA-N 50130707 CHEMBL3632747 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.09.008 10.7270/Q2S184B8 26408454 Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130707&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122194701 321903164 CHEMBL3632747 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445333 CN(C)CC(=O)Nc1cccc(Nc2ncc(F)c(Nc3ccc(F)cc3)n2)c1 InChI=1S/C20H20F2N6O/c1-28(2)12-18(29)24-15-4-3-5-16(10-15)26-20-23-11-17(22)19(27-20)25-14-8-6-13(21)7-9-14/h3-11H,12H2,1-2H3,(H,24,29)(H2,23,25,26,27) QWUFJOPBOHFZST-UHFFFAOYSA-N 50134089 CHEMBL3735502 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 780 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134089&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127037298 336951474 CHEMBL3735502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445335 CC(=O)N1CCCN(CC1)C(=O)c1cccc(Nc2ncc(F)c(Nc3ccc(F)cc3)n2)c1 InChI=1S/C24H24F2N6O2/c1-16(33)31-10-3-11-32(13-12-31)23(34)17-4-2-5-20(14-17)29-24-27-15-21(26)22(30-24)28-19-8-6-18(25)7-9-19/h2,4-9,14-15H,3,10-13H2,1H3,(H2,27,28,29,30) HPVUSXYRRLEIOH-UHFFFAOYSA-N 50134092 CHEMBL3735063 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15600 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134092&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127034840 336951477 CHEMBL3735063 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445336 COc1ccc(cc1Nc1ncc(F)c(Nc2ccc(F)cc2)n1)N1CCN(C)CC1 InChI=1S/C22H24F2N6O/c1-29-9-11-30(12-10-29)17-7-8-20(31-2)19(13-17)27-22-25-14-18(24)21(28-22)26-16-5-3-15(23)4-6-16/h3-8,13-14H,9-12H2,1-2H3,(H2,25,26,27,28) CUOAVZSCGCGQOW-UHFFFAOYSA-N 50134086 CHEMBL3735072 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127036907 336951471 CHEMBL3735072 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445338 CN(C)CCNC(=O)c1cccc(Nc2ncc(F)c(Nc3ccc(F)cc3)n2)c1 InChI=1S/C21H22F2N6O/c1-29(2)11-10-24-20(30)14-4-3-5-17(12-14)27-21-25-13-18(23)19(28-21)26-16-8-6-15(22)7-9-16/h3-9,12-13H,10-11H2,1-2H3,(H,24,30)(H2,25,26,27,28) UUDACZFYVGYWFK-UHFFFAOYSA-N 50134179 CHEMBL3735818 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1720 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134179&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127035687 336951478 CHEMBL3735818 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445339 COCC(=O)Nc1cccc(Nc2ncc(F)c(Nc3ccc(F)cc3)n2)c1 InChI=1S/C19H17F2N5O2/c1-28-11-17(27)23-14-3-2-4-15(9-14)25-19-22-10-16(21)18(26-19)24-13-7-5-12(20)6-8-13/h2-10H,11H2,1H3,(H,23,27)(H2,22,24,25,26) DRLYKENBFABLON-UHFFFAOYSA-N 50134090 CHEMBL3735561 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2020 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134090&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127036079 336951475 CHEMBL3735561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445340 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.6 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50445341 Fc1ccc(Nc2nc(Nc3cccc(NC(=O)c4ccncc4)c3)ncc2F)cc1 InChI=1S/C22H16F2N6O/c23-15-4-6-16(7-5-15)27-20-19(24)13-26-22(30-20)29-18-3-1-2-17(12-18)28-21(31)14-8-10-25-11-9-14/h1-13H,(H,28,31)(H2,26,27,29,30) FDAYZHDVQHDQGW-UHFFFAOYSA-N 50134087 CHEMBL3735656 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2570 ChEMBL 10.1039/c4md00412d 10.7270/Q2CJ8G9D 25914804 Gao, J; Fang, C; Xiao, Z; Huang, L; Chen, CH; Wang, LT; Lee, KH Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134087&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127035029 336951472 CHEMBL3735656 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50495842 NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 InChI=1S/C14H9ClN2O2S/c15-8-1-3-9(4-2-8)19-11-6-17-7-13-10(11)5-12(20-13)14(16)18/h1-7H,(H2,16,18) ONVYPVVYNXLFQK-UHFFFAOYSA-N 50105181 4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid amide::CHEMBL118518 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2200 ChEMBL 10.1021/acsmedchemlett.5b00278 10.7270/Q29G5PPC 26985305 Koehler, MF; Bergeron, P; Blackwood, EM; Bowman, K; Clark, KR; Firestein, R; Kiefer, JR; Maskos, K; McCleland, ML; Orren, L; Salphati, L; Schmidt, S; Schneider, EV; Wu, J; Beresini, MH Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105181&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 9879529 104000976 CHEMBL118518 ZINC00008924 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50495843 NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(N)c2s1 InChI=1S/C14H10ClN3O2S/c15-7-1-3-8(4-2-7)20-10-6-18-13(16)12-9(10)5-11(21-12)14(17)19/h1-6H,(H2,16,18)(H2,17,19) ZMWFSXAKXCNWGH-UHFFFAOYSA-N 50169062 CHEMBL3805194 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1021/acsmedchemlett.5b00278 10.7270/Q29G5PPC 26985305 Koehler, MF; Bergeron, P; Blackwood, EM; Bowman, K; Clark, KR; Firestein, R; Kiefer, JR; Maskos, K; McCleland, ML; Orren, L; Salphati, L; Schmidt, S; Schneider, EV; Wu, J; Beresini, MH Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169062&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 127050134 341104711 CHEMBL3805194 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50515786 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(C)cc2=O InChI=1S/C16H19NO5/c1-8-5-10(18)15-12(20)6-11(19)14(16(15)22-8)9-3-4-17(2)7-13(9)21/h5-6,9,13,19-21H,3-4,7H2,1-2H3/t9-,13+/m0/s1 MOCVYVBNJQIVOV-TVQRCGJNSA-N 50189885 Rohitukine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 ChEMBL 10.1016/j.bmcl.2016.06.046 10.7270/Q2M90BMH 27363938 Kumar, V; Guru, SK; Jain, SK; Joshi, P; Gandhi, SG; Bharate, SB; Bhushan, S; Bharate, SS; Vishwakarma, RA India Academy of Scientific & Innovative Research (AcSIR) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50189885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50189885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 13422573 346535251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50635141 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2n[nH]c(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-14(11-26)21-19-22-16-15(12(2)3)24-25-17(16)18(23-19)20-10-13-8-6-5-7-9-13/h5-9,12,14,26H,4,10-11H2,1-3H3,(H,24,25)(H2,20,21,22,23)/t14-/m1/s1 AOPRHEOJTUWSAR-CQSZACIVSA-N 50341878 (2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-ol::7-Benzylamino-5(R)-[2-(hydroxymethyl)propyl]amino-3-isopropyl-1(2)H-pyrazolo[4,3-d]pyrimidine::CHEMBL1738742 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/jm200064p 10.7270/Q20K28XN 21417417 Jorda, R; Havlicek, L; McNae, IW; Walkinshaw, MD; Voller, J; Sturc, A; Navratilova, J; Kuzma, M; Mistrik, M; Bartek, J; Strnad, M; Krystof, V Palacky£? University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 51000420 131344814 CHEMBL1738742 ZINC66166057 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50635145 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1770 ChEMBL 10.1021/jm200064p 10.7270/Q20K28XN 21417417 Jorda, R; Havlicek, L; McNae, IW; Walkinshaw, MD; Voller, J; Sturc, A; Navratilova, J; Kuzma, M; Mistrik, M; Bartek, J; Strnad, M; Krystof, V Palacky£? University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50644898 O=C1Cc2c([nH]c3ccccc23)-c2ccccc2N1 InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) VGMDAWVZNAXVDG-UHFFFAOYSA-N 7287 8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::CHEMBL430574::NSC 641166::Paullone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 810 ChEMBL 10.1016/j.bmcl.2010.06.024 10.7270/Q21836T2 20621478 Power, DP; Lozach, O; Meijer, L; Grayson, DH; Connon, SJ Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7287&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 369401 8036843 CHEMBL430574 ZINC01626613 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50644906 Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) QQUXFYAWXPMDOE-UHFFFAOYSA-N 7266 14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::9-bromopaullone::CHEMBL296586::Kenpaullone::NSC 664704::Paullone Analog 5::cid_3820 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64 ChEMBL 10.1016/j.bmcl.2010.06.024 10.7270/Q21836T2 20621478 Power, DP; Lozach, O; Meijer, L; Grayson, DH; Connon, SJ Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7266&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 3820 8036822 CHEMBL296586 6000 ZINC01639355 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50644914 O=C1Cc2c([nH]c3ccncc23)-c2ccccc2N1 InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) WOUDPYBESPZALS-UHFFFAOYSA-N 50346235 9-azapaullone::CHEMBL1782168 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2010.06.024 10.7270/Q21836T2 20621478 Power, DP; Lozach, O; Meijer, L; Grayson, DH; Connon, SJ Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50346235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50346235&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 54582100 131349166 CHEMBL1782168 ZINC71295931 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50644921 O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 OYRDVNBEBYNKPM-UHFFFAOYSA-O 50346236 9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-azonia-dibenzo[a,e]azulene bromide::CHEMBL1782169 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7400 ChEMBL 10.1016/j.bmcl.2010.06.024 10.7270/Q21836T2 20621478 Power, DP; Lozach, O; Meijer, L; Grayson, DH; Connon, SJ Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50346236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50346236&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 54585956 131349167 CHEMBL1782169 ZINC71295330 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50644928 [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) QSSHEITWSXIQFH-UHFFFAOYSA-N 50346237 9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]azulen-6-one::CHEMBL1782170 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2010.06.024 10.7270/Q21836T2 20621478 Power, DP; Lozach, O; Meijer, L; Grayson, DH; Connon, SJ Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50346237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50346237&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46918486 131349168 CHEMBL1782170 ZINC71280977 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50703966 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-8-7-9-21-10-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m1/s1 SQUNXPPTEPGMQR-OAHLLOKOSA-N 50358210 CHEMBL1922123::US8846696, (3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11574520 136962234 CHEMBL1922123 ZINC03939653 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50703967 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-8-7-9-21-10-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m0/s1 SQUNXPPTEPGMQR-HNNXBMFYSA-N 50358211 CHEMBL1922212::US8846696, (3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358211&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11581762 136962235 CHEMBL1922212 ZINC03939654 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50703968 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m0/s1 SCACHXWSWJBIHG-DZGCQCFKSA-N 50358212 CHEMBL1922218::US8846696, (2S3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 12111408 136962236 CHEMBL1922218 ZINC03939648 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50703969 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m1/s1 SCACHXWSWJBIHG-HIFRSBDPSA-N 50358213 CHEMBL1922219::US8846696, (2R3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358213&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 8QT 5MHQ 9842276 136962237 CHEMBL1922219 ZINC03939649 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50715811 Cc1nc2cc(Cl)c(Cl)cc2n1C1CCCC1 InChI=1S/C13H14Cl2N2/c1-8-16-12-6-10(14)11(15)7-13(12)17(8)9-4-2-3-5-9/h6-7,9H,2-5H2,1H3 XKFCABYIFKGDPX-UHFFFAOYSA-N 50363399 CHEMBL1946633 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1510 ChEMBL 10.1016/j.bmcl.2011.12.088 10.7270/Q2NZ883V 22225635 Alkahtani, HM; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363399&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57335322 136967461 CHEMBL1946633 ZINC82160493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50715812 CC(C)c1nc2cc(Cl)c(Cl)cc2n1C1CCCC1 InChI=1S/C15H18Cl2N2/c1-9(2)15-18-13-7-11(16)12(17)8-14(13)19(15)10-5-3-4-6-10/h7-10H,3-6H2,1-2H3 UWRDBDMCPHVMIQ-UHFFFAOYSA-N 50363400 CHEMBL1946636 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3330 ChEMBL 10.1016/j.bmcl.2011.12.088 10.7270/Q2NZ883V 22225635 Alkahtani, HM; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363400&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57397039 136967462 CHEMBL1946636 ZINC82151977 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50715813 CSc1nc2cc(Cl)c(Cl)cc2n1C1CCCC1 InChI=1S/C13H14Cl2N2S/c1-18-13-16-11-6-9(14)10(15)7-12(11)17(13)8-4-2-3-5-8/h6-8H,2-5H2,1H3 HFCFUBVALIMMOD-UHFFFAOYSA-N 50363401 CHEMBL1946637 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1016/j.bmcl.2011.12.088 10.7270/Q2NZ883V 22225635 Alkahtani, HM; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363401&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57395269 136967463 CHEMBL1946637 ZINC82160497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50715814 CS(=O)c1nc2cc(Cl)c(Cl)cc2n1C1CCCC1 InChI=1S/C13H14Cl2N2OS/c1-19(18)13-16-11-6-9(14)10(15)7-12(11)17(13)8-4-2-3-5-8/h6-8H,2-5H2,1H3 JEHSPYPIDBKMLL-UHFFFAOYSA-N 50363402 CHEMBL1946638 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1016/j.bmcl.2011.12.088 10.7270/Q2NZ883V 22225635 Alkahtani, HM; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57335323 136967464 CHEMBL1946638 ZINC84564610 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50715815 CS(=O)(=O)c1nc2cc(Cl)c(Cl)cc2n1C1CCCC1 InChI=1S/C13H14Cl2N2O2S/c1-20(18,19)13-16-11-6-9(14)10(15)7-12(11)17(13)8-4-2-3-5-8/h6-8H,2-5H2,1H3 SUNLCLCYSNLSKY-UHFFFAOYSA-N 50363403 CHEMBL1946639 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1016/j.bmcl.2011.12.088 10.7270/Q2NZ883V 22225635 Alkahtani, HM; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57335324 136967465 CHEMBL1946639 ZINC84564612 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854460 Oc1ccnc2[nH]cc(-c3ccncn3)c12 InChI=1S/C11H8N4O/c16-9-2-4-13-11-10(9)7(5-14-11)8-1-3-12-6-15-8/h1-6H,(H2,13,14,16) HGRCTDVEDIQMPR-UHFFFAOYSA-N 50371407 CHEMBL405200 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801182 160850508 CHEMBL405200 ZINC29135003 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854461 Nc1nccc(n1)-c1c[nH]c2nccc(Cl)c12 InChI=1S/C11H8ClN5/c12-7-1-3-14-10-9(7)6(5-16-10)8-2-4-15-11(13)17-8/h1-5H,(H,14,16)(H2,13,15,17) DTBMYSHZPNXMDE-UHFFFAOYSA-N 50371409 CHEMBL271597 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371409&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801183 160850510 CHEMBL271597 ZINC29135071 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854462 CC(C)Oc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C14H15N5O/c1-8(2)20-11-4-6-16-13-12(11)9(7-18-13)10-3-5-17-14(15)19-10/h3-8H,1-2H3,(H,16,18)(H2,15,17,19) YRURITXEWXPMAI-UHFFFAOYSA-N 50371399 MERIOLIN 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.6 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371399&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801185 160850500 ZINC29135117 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854463 COc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C12H11N5O/c1-18-9-3-5-14-11-10(9)7(6-16-11)8-2-4-15-12(13)17-8/h2-6H,1H3,(H,14,16)(H2,13,15,17) GGEWEQJWGGJUHO-UHFFFAOYSA-N 50371402 MERIOLIN 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search MFR 3BHT,7A5B 23727981 160850503 DB08178 ZINC16052675 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854428 COc1ccnc2c1c(-c1ccnc(N)n1)c1ccnc(N)n21 InChI=1S/C15H13N7O/c1-23-10-4-7-18-13-12(10)11(8-2-5-19-14(16)21-8)9-3-6-20-15(17)22(9)13/h2-7H,1H3,(H2,17,20)(H2,16,19,21) IWXIAMLCFOOOMV-UHFFFAOYSA-N 50371405 CHEMBL411704 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371405&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 9922607 160850506 CHEMBL411704 ZINC29135230 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854441 COc1ccnc2[nH]cc(-c3ccncn3)c12 InChI=1S/C12H10N4O/c1-17-10-3-5-14-12-11(10)8(6-15-12)9-2-4-13-7-16-9/h2-7H,1H3,(H,14,15) DTOLBYZPXCACLH-UHFFFAOYSA-N 50371406 CHEMBL402443 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801700 160850507 CHEMBL402443 ZINC29135005 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854442 COc1ccnc2[nH]cc(-c3ccnc(SC)n3)c12 InChI=1S/C13H12N4OS/c1-18-10-4-6-14-12-11(10)8(7-16-12)9-3-5-15-13(17-9)19-2/h3-7H,1-2H3,(H,14,16) AJLTWCLIFVXAEJ-UHFFFAOYSA-N 50371408 CHEMBL270926 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24799078 160850509 CHEMBL270926 ZINC29135001 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854443 Nc1nccc(n1)-c1c[nH]c2nc(Br)ccc12 InChI=1S/C11H8BrN5/c12-9-2-1-6-7(5-15-10(6)17-9)8-3-4-14-11(13)16-8/h1-5H,(H,15,17)(H2,13,14,16) AFELDORIFDMULD-UHFFFAOYSA-N 50371411 CHEMBL271195 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371411&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801184 160850512 CHEMBL271195 ZINC29135065 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854444 COc1ccnc2n(C)cc(-c3ccnc(N)n3)c12 InChI=1S/C13H13N5O/c1-18-7-8(9-3-5-16-13(14)17-9)11-10(19-2)4-6-15-12(11)18/h3-7H,1-2H3,(H2,14,16,17) CPQCGVRZSBLZLT-UHFFFAOYSA-N 50371410 MERIOLIN 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801698 160850511 ZINC29135067 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854445 Cn1cc(-c2ccnc(N)n2)c2c(O)ccnc12 InChI=1S/C12H11N5O/c1-17-6-7(8-2-4-15-12(13)16-8)10-9(18)3-5-14-11(10)17/h2-6H,1H3,(H,14,18)(H2,13,15,16) PYDJIICXCHAWOI-UHFFFAOYSA-N 50371397 MERIOLIN 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1200 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801181 160850498 ZINC29135069 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854446 COCCOc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C14H15N5O2/c1-20-6-7-21-11-3-5-16-13-12(11)9(8-18-13)10-2-4-17-14(15)19-10/h2-5,8H,6-7H2,1H3,(H,16,18)(H2,15,17,19) NFOHQNIARGGZFN-UHFFFAOYSA-N 50371398 MERIOLIN 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5300 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371398&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801186 160850499 ZINC29135076 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854447 CCCOc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C14H15N5O/c1-2-7-20-11-4-6-16-13-12(11)9(8-18-13)10-3-5-17-14(15)19-10/h3-6,8H,2,7H2,1H3,(H,16,18)(H2,15,17,19) ZHMRPXZRUZLCNL-UHFFFAOYSA-N 50371400 MERIOLIN 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.6 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371400&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search MHR 3BHU 23727982 160850501 DB08182 ZINC16052674 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854448 CCOc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C13H13N5O/c1-2-19-10-4-6-15-12-11(10)8(7-17-12)9-3-5-16-13(14)18-9/h3-7H,2H2,1H3,(H,15,17)(H2,14,16,18) CJJMNECGBUPMAV-UHFFFAOYSA-N 50371401 MERIOLIN 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371401&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801697 160850502 ZINC29135119 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854449 Nc1nccc(n1)-c1c[nH]c2nccc(O)c12 InChI=1S/C11H9N5O/c12-11-14-3-1-7(16-11)6-5-15-10-9(6)8(17)2-4-13-10/h1-5H,(H2,12,14,16)(H2,13,15,17) JYGNOLIKBUTZNC-UHFFFAOYSA-N 50371403 MERIOLIN 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801699 160850504 ZINC29135124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50854450 Nc1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C11H9N5/c12-11-14-5-3-9(16-11)8-6-15-10-7(8)2-1-4-13-10/h1-6H,(H,13,15)(H2,12,14,16) HQHSJJZIICGOIX-UHFFFAOYSA-N 50371404 MERIOLIN 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1021/jm700940h 10.7270/Q2ZP46ZR 18232649 Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clement, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11637090 160850505 ZINC29135178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953166 Cn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C18H16N6O2S/c1-24-16-5-3-2-4-14(16)17(23-24)15-10-11-20-18(22-15)21-12-6-8-13(9-7-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22) ZFEYLWUPVGFOSD-UHFFFAOYSA-N 50391211 CHEMBL2088826 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391211&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70682821 160870294 CHEMBL2088826 ZINC84690007 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953167 Cn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C18H16N6O2S/c1-24-16-8-3-2-7-14(16)17(23-24)15-9-10-20-18(22-15)21-12-5-4-6-13(11-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22) ZGYYSZDEERINCY-UHFFFAOYSA-N 50391212 CHEMBL2088827 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70691236 160870295 CHEMBL2088827 ZINC84739777 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953168 CCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C19H18N6O2S/c1-2-25-17-6-4-3-5-15(17)18(24-25)16-11-12-21-19(23-16)22-13-7-9-14(10-8-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23) KUGVZTUWNUHAHF-UHFFFAOYSA-N 50391213 CHEMBL2088828 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 253 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391213&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70689145 160870296 CHEMBL2088828 ZINC84739783 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953169 CCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C19H18N6O2S/c1-2-25-17-9-4-3-8-15(17)18(24-25)16-10-11-21-19(23-16)22-13-6-5-7-14(12-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23) XLVAOYFVEAWDSR-UHFFFAOYSA-N 50391214 CHEMBL2088829 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 154 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391214&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70684896 160870297 CHEMBL2088829 ZINC84739787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953170 CCCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C20H20N6O2S/c1-2-13-26-18-6-4-3-5-16(18)19(25-26)17-11-12-22-20(24-17)23-14-7-9-15(10-8-14)29(21,27)28/h3-12H,2,13H2,1H3,(H2,21,27,28)(H,22,23,24) VRHNNRWRKNFLEX-UHFFFAOYSA-N 50391215 CHEMBL2088835 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 176 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391215&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70684897 160870298 CHEMBL2088835 ZINC84739215 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953171 NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)cc1 InChI=1S/C23H19N7O2S/c24-33(31,32)18-9-7-17(8-10-18)27-23-26-13-11-20(28-23)22-19-5-1-2-6-21(19)30(29-22)15-16-4-3-12-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28) NXXCZSSBACNPLO-UHFFFAOYSA-N 50391217 CHEMBL2088837 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 207 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70695451 160870300 CHEMBL2088837 ZINC84733060 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953172 NS(=O)(=O)c1cccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)c1 InChI=1S/C23H19N7O2S/c24-33(31,32)18-7-3-6-17(13-18)27-23-26-12-10-20(28-23)22-19-8-1-2-9-21(19)30(29-22)15-16-5-4-11-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28) LDBOYZUPWICGFP-UHFFFAOYSA-N 50391218 CHEMBL2088838 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 314 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391218&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70684898 160870301 CHEMBL2088838 ZINC84725380 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953173 NS(=O)(=O)c1ccc(Nc2nccc(n2)-n2ncc3ccccc23)cc1 InChI=1S/C17H14N6O2S/c18-26(24,25)14-7-5-13(6-8-14)21-17-19-10-9-16(22-17)23-15-4-2-1-3-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22) MGYDUQVCVWCQMO-UHFFFAOYSA-N 50391209 CHEMBL2088839 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391209&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70691237 160870292 CHEMBL2088839 ZINC84733065 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953174 NS(=O)(=O)c1cccc(Nc2nccc(n2)-n2ncc3ccccc23)c1 InChI=1S/C17H14N6O2S/c18-26(24,25)14-6-3-5-13(10-14)21-17-19-9-8-16(22-17)23-15-7-2-1-4-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22) VLROOZRSNWRFKW-UHFFFAOYSA-N 50391210 CHEMBL2088840 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24959532 160870293 CHEMBL2088840 ZINC84733068 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953183 CCCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C20H20N6O2S/c1-2-12-26-18-9-4-3-8-16(18)19(25-26)17-10-11-22-20(24-17)23-14-6-5-7-15(13-14)29(21,27)28/h3-11,13H,2,12H2,1H3,(H2,21,27,28)(H,22,23,24) CRAMQTAMSPUOSC-UHFFFAOYSA-N 50391216 CHEMBL2088836 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 285 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391216&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70687054 160870299 CHEMBL2088836 ZINC84688281 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50972130 O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1 InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21) PGPHHJBZEGSUNE-UHFFFAOYSA-N 50347750 CHEMBL1802358 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347750&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25230621 136354436 CHEMBL1802358 ZINC59182036 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50972149 CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O InChI=1S/C12H11N3O3/c1-15-11(16)8(14-12(15)13)4-7-2-3-9-10(5-7)18-6-17-9/h2-5H,6H2,1H3,(H2,13,14) PKEDBIGNILOTHW-UHFFFAOYSA-N 50292406 CHEMBL485053::leucettamine B Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50292406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50292406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 10037501 104133957 CHEMBL485053 ZINC34118117 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50972168 COc1ccc2c(c1)[nH]c1c(C)nccc21 InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 BXNJHAXVSOCGBA-UHFFFAOYSA-N 100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 720 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100152&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search HRM 7X9D,5Y86,2Z5X,3ANR,2Z5Y 5280953 252663240 28121 DB07919 C06538 ZINC18847046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084216 NCCOCCOCCOc1ccc(NC2=NC(=Cc3ccccc3)C(=O)N2)cc1 InChI=1S/C22H26N4O4/c23-10-11-28-12-13-29-14-15-30-19-8-6-18(7-9-19)24-22-25-20(21(27)26-22)16-17-4-2-1-3-5-17/h1-9,16H,10-15,23H2,(H2,24,25,26,27) CQNULDWOIXHYFM-UHFFFAOYSA-N 50443637 CHEMBL3092864 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2013.01.035 10.7270/Q2T1553Q 23454515 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Universit£ de Rennes1 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443637&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71653344 194941533 CHEMBL3092864 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084217 NCCOCCOCCOCCOc1ccc(NC2=NC(=Cc3ccc4OCOc4c3)C(=O)N2)cc1 InChI=1S/C25H30N4O7/c26-7-8-31-9-10-32-11-12-33-13-14-34-20-4-2-19(3-5-20)27-25-28-21(24(30)29-25)15-18-1-6-22-23(16-18)36-17-35-22/h1-6,15-16H,7-14,17,26H2,(H2,27,28,29,30) ZBYBDKHFLSHGBP-UHFFFAOYSA-N 50443638 CHEMBL3092863 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3700 ChEMBL 10.1016/j.ejmech.2013.01.035 10.7270/Q2T1553Q 23454515 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Universit£ de Rennes1 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443638&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71653343 194941534 CHEMBL3092863 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084218 NCCOCCOCCOc1ccc(NC2=NC(=Cc3ccc4OCOc4c3)C(=O)N2)cc1 InChI=1S/C23H26N4O6/c24-7-8-29-9-10-30-11-12-31-18-4-2-17(3-5-18)25-23-26-19(22(28)27-23)13-16-1-6-20-21(14-16)33-15-32-20/h1-6,13-14H,7-12,15,24H2,(H2,25,26,27,28) LZUJDIWVWSRLRQ-UHFFFAOYSA-N 50443639 CHEMBL3092862 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7400 ChEMBL 10.1016/j.ejmech.2013.01.035 10.7270/Q2T1553Q 23454515 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Universit£ de Rennes1 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443639&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71653342 194941535 CHEMBL3092862 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084219 NCCOCCOCCO InChI=1S/C6H15NO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-7H2 ASDQMECUMYIVBG-UHFFFAOYSA-N 50443640 CHEMBL3092861 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2013.01.035 10.7270/Q2T1553Q 23454515 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Universit£ de Rennes1 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443640&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 95875 194941536 CHEMBL3092861 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084220 O=C1NC(Nc2ccccc2)=NC1=Cc1ccccc1 InChI=1S/C16H13N3O/c20-15-14(11-12-7-3-1-4-8-12)18-16(19-15)17-13-9-5-2-6-10-13/h1-11H,(H2,17,18,19,20) PBNKEANYJCQEQI-UHFFFAOYSA-N 50443641 CHEMBL3092860 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2013.01.035 10.7270/Q2T1553Q 23454515 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Universit£ de Rennes1 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443641&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 12204730 194941537 CHEMBL3092860 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084221 O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1 InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21) PGPHHJBZEGSUNE-UHFFFAOYSA-N 50347750 CHEMBL1802358 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2013.01.035 10.7270/Q2T1553Q 23454515 Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Universit£ de Rennes1 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347750&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25230621 136354436 CHEMBL1802358 ZINC59182036 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084292 Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1 KSGGOJKIGSSSBJ-CQSZACIVSA-N 50443644 CHEMBL3093080 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 460 ChEMBL 10.1016/j.bmcl.2013.09.055 10.7270/Q2P84DC0 24120542 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443644&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72544395 194941540 CHEMBL3093080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084293 Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1 InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1 OIBUTVCVLWVDLE-CQSZACIVSA-N 50443645 CHEMBL3093079 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2013.09.055 10.7270/Q2P84DC0 24120542 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443645&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72544175 194941541 CHEMBL3093079 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084294 Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1 VWWJMBYBXMDFAV-OAHLLOKOSA-N 50443646 CHEMBL3093078 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2013.09.055 10.7270/Q2P84DC0 24120542 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443646&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72544174 194941542 CHEMBL3093078 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084295 Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1 RYHDTMIFZDAZSM-OAHLLOKOSA-N 50443647 CHEMBL3093077 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 940 ChEMBL 10.1016/j.bmcl.2013.09.055 10.7270/Q2P84DC0 24120542 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443647&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72544173 194941543 CHEMBL3093077 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084296 Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1 LNXSSTKGTQNUBH-CQSZACIVSA-N 50443648 CHEMBL3093076 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 ChEMBL 10.1016/j.bmcl.2013.09.055 10.7270/Q2P84DC0 24120542 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443648&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72544172 194941544 CHEMBL3093076 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51084297 Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1 YFZAJIBGNYMWBT-MRXNPFEDSA-N 50443649 CHEMBL3093075 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2013.09.055 10.7270/Q2P84DC0 24120542 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443649&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72544171 194941545 CHEMBL3093075 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083816 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)NC2CCN(C)CC2)ncc1C#N InChI=1S/C23H26N8OS/c1-14-20(33-23(25-2)27-14)19-16(12-24)13-26-22(30-19)29-18-6-4-5-15(11-18)21(32)28-17-7-9-31(3)10-8-17/h4-6,11,13,17H,7-10H2,1-3H3,(H,25,27)(H,28,32)(H,26,29,30) HAOOVLDCSQZODX-UHFFFAOYSA-N 50443456 CHEMBL3087432 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76328016 194941352 CHEMBL3087432 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083817 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)ncc1C#N InChI=1S/C23H26N8OS/c1-14-20(33-23(25-2)27-14)19-16(12-24)13-26-22(30-19)29-17-6-4-15(5-7-17)21(32)28-18-8-10-31(3)11-9-18/h4-7,13,18H,8-11H2,1-3H3,(H,25,27)(H,28,32)(H,26,29,30) ANZDEYYSOIFTCU-UHFFFAOYSA-N 50443457 CHEMBL3087433 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443457&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76313579 194941353 CHEMBL3087433 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083818 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)NC2CCN(C)CC2)ncc1F InChI=1S/C22H26FN7OS/c1-13-19(32-22(24-2)26-13)18-17(23)12-25-21(29-18)28-16-6-4-5-14(11-16)20(31)27-15-7-9-30(3)10-8-15/h4-6,11-12,15H,7-10H2,1-3H3,(H,24,26)(H,27,31)(H,25,28,29) AFCWHBYSCXCKFL-UHFFFAOYSA-N 50443458 CHEMBL3087434 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76309866 194941354 CHEMBL3087434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083819 CNc1nc(C)c(s1)-c1nc(Nc2cc(ccc2Cl)C(=O)N2CCN(C)CC2)ncc1C#N InChI=1S/C22H23ClN8OS/c1-13-19(33-22(25-2)27-13)18-15(11-24)12-26-21(29-18)28-17-10-14(4-5-16(17)23)20(32)31-8-6-30(3)7-9-31/h4-5,10,12H,6-9H2,1-3H3,(H,25,27)(H,26,28,29) NGIUJEJHSLLBCD-UHFFFAOYSA-N 50443459 CHEMBL3087435 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 715 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443459&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76313580 194941355 CHEMBL3087435 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083820 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCN(C)CC2)ncc1C#N InChI=1S/C22H24N8OS/c1-14-19(32-22(24-2)26-14)18-16(12-23)13-25-21(28-18)27-17-6-4-5-15(11-17)20(31)30-9-7-29(3)8-10-30/h4-6,11,13H,7-10H2,1-3H3,(H,24,26)(H,25,27,28) ROGLCZFAMZYZJO-UHFFFAOYSA-N 50443443 CHEMBL3087436 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443443&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74222731 194941339 CHEMBL3087436 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083821 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C23H24N8O2S/c1-14-20(34-23(25-3)27-14)19-17(12-24)13-26-22(29-19)28-18-6-4-5-16(11-18)21(33)31-9-7-30(8-10-31)15(2)32/h4-6,11,13H,7-10H2,1-3H3,(H,25,27)(H,26,28,29) APNXOACTQOYOLQ-UHFFFAOYSA-N 50443444 CHEMBL3087437 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443444&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253321 194941340 CHEMBL3087437 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083822 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCOCC2)ncc1C#N InChI=1S/C21H21N7O2S/c1-13-18(31-21(23-2)25-13)17-15(11-22)12-24-20(27-17)26-16-5-3-4-14(10-16)19(29)28-6-8-30-9-7-28/h3-5,10,12H,6-9H2,1-2H3,(H,23,25)(H,24,26,27) UFUGKBGESCNADR-UHFFFAOYSA-N 50425002 CHEMBL2312191 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425002&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search TJF 4BCQ 44253188 164153877 CHEMBL2312191 ZINC95593936 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083823 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)C(=O)N2CCOCC2)n1 InChI=1S/C20H22N6O2S/c1-13-17(29-20(21-2)23-13)16-6-7-22-19(25-16)24-15-5-3-4-14(12-15)18(27)26-8-10-28-11-9-26/h3-7,12H,8-11H2,1-2H3,(H,21,23)(H,22,24,25) BVPOKPFALSNQSI-UHFFFAOYSA-N 50443445 CHEMBL3087438 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76331677 194941341 CHEMBL3087438 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083824 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)N2CCN(C)CC2)ncc1C#N InChI=1S/C21H24N8O2S2/c1-14-19(32-21(23-2)25-14)18-15(12-22)13-24-20(27-18)26-16-5-4-6-17(11-16)33(30,31)29-9-7-28(3)8-10-29/h4-6,11,13H,7-10H2,1-3H3,(H,23,25)(H,24,26,27) YKBWHMMFNLYZNJ-UHFFFAOYSA-N 50443446 CHEMBL3087439 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76317084 194941342 CHEMBL3087439 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083825 CNc1nc(C)c(s1)-c1nc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)ncc1F InChI=1S/C20H23FN6O3S2/c1-12-4-5-14(10-16(12)32(28,29)27-6-8-30-9-7-27)25-19-23-11-15(21)17(26-19)18-13(2)24-20(22-3)31-18/h4-5,10-11H,6-9H2,1-3H3,(H,22,24)(H,23,25,26) JADZIABDRVBRMR-UHFFFAOYSA-N 50443447 CHEMBL3087440 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443447&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76309867 194941343 CHEMBL3087440 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083826 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)N2CCOCC2)ncc1C#N InChI=1S/C20H21N7O3S2/c1-13-18(31-20(22-2)24-13)17-14(11-21)12-23-19(26-17)25-15-4-3-5-16(10-15)32(28,29)27-6-8-30-9-7-27/h3-5,10,12H,6-9H2,1-2H3,(H,22,24)(H,23,25,26) AFYLTDZJAWPVBM-UHFFFAOYSA-N 50443448 CHEMBL3087441 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443448&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253464 194941344 CHEMBL3087441 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083827 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)NCCOC)ncc1F InChI=1S/C18H21FN6O3S2/c1-11-16(29-18(20-2)23-11)15-14(19)10-21-17(25-15)24-12-5-4-6-13(9-12)30(26,27)22-7-8-28-3/h4-6,9-10,22H,7-8H2,1-3H3,(H,20,23)(H,21,24,25) CGBFAYLLULJFBW-UHFFFAOYSA-N 50443449 CHEMBL3087442 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76313581 194941345 CHEMBL3087442 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083828 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)NCCOC)ncc1C#N InChI=1S/C19H21N7O3S2/c1-12-17(30-19(21-2)24-12)16-13(10-20)11-22-18(26-16)25-14-5-4-6-15(9-14)31(27,28)23-7-8-29-3/h4-6,9,11,23H,7-8H2,1-3H3,(H,21,24)(H,22,25,26) AZPRRIBSKMOFDL-UHFFFAOYSA-N 50443450 CHEMBL3087443 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443450&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76313582 194941346 CHEMBL3087443 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083829 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H16N6O2S2/c1-10-15(26-17(19-2)21-10)14-11(8-18)9-20-16(23-14)22-12-5-4-6-13(7-12)27(3,24)25/h4-7,9H,1-3H3,(H,19,21)(H,20,22,23) WVRPZYQKQWOMIH-UHFFFAOYSA-N 50443451 CHEMBL3087444 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443451&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44253466 194941347 CHEMBL3087444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083830 CN1CCN(CC1)c1cccc(Nc2ncc(F)c(n2)-c2sc(N)nc2C)c1 InChI=1S/C19H22FN7S/c1-12-17(28-18(21)23-12)16-15(20)11-22-19(25-16)24-13-4-3-5-14(10-13)27-8-6-26(2)7-9-27/h3-5,10-11H,6-9H2,1-2H3,(H2,21,23)(H,22,24,25) LRPFDZCHJQTXPT-UHFFFAOYSA-N 50443452 CHEMBL3087445 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443452&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76317085 194941348 CHEMBL3087445 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083831 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(C)CC2)ncc1F InChI=1S/C20H24FN7S/c1-13-18(29-20(22-2)24-13)17-16(21)12-23-19(26-17)25-14-5-4-6-15(11-14)28-9-7-27(3)8-10-28/h4-6,11-12H,7-10H2,1-3H3,(H,22,24)(H,23,25,26) PJIPYWGIYRUKIG-UHFFFAOYSA-N 50443453 CHEMBL3087447 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.0 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443453&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76317086 194941349 CHEMBL3087447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083832 CC(=O)N1CCN(CC1)c1cccc(Nc2ncc(F)c(n2)-c2sc(N)nc2C)c1 InChI=1S/C20H22FN7OS/c1-12-18(30-19(22)24-12)17-16(21)11-23-20(26-17)25-14-4-3-5-15(10-14)28-8-6-27(7-9-28)13(2)29/h3-5,10-11H,6-9H2,1-2H3,(H2,22,24)(H,23,25,26) DLENXRXJIRCJJB-UHFFFAOYSA-N 50443454 CHEMBL3087446 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76335286 194941350 CHEMBL3087446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083833 Cc1nc(N)sc1-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F InChI=1S/C14H13FN6O2S2/c1-7-12(24-13(16)19-7)11-10(15)6-18-14(21-11)20-8-3-2-4-9(5-8)25(17,22)23/h2-6H,1H3,(H2,16,19)(H2,17,22,23)(H,18,20,21) BQLLLVDIZXOQJD-UHFFFAOYSA-N 50443455 CHEMBL3087448 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443455&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 72204789 194941351 CHEMBL3087448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51083877 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C20H24N6O3S2/c1-13-4-5-15(12-17(13)31(27,28)26-8-10-29-11-9-26)24-19-22-7-6-16(25-19)18-14(2)23-20(21-3)30-18/h4-7,12H,8-11H2,1-3H3,(H,21,23)(H,22,24,25) NNMRZPOMVQNXMS-UHFFFAOYSA-N 81436 CDK Inhibitor, 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81436&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11510921 131342010 ZINC43101526 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476511 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccnc(F)c2)c1 InChI=1S/C23H20F2N6O2S/c1-34(26,32)13-16-3-2-4-18(9-16)30-23-29-14-28-22(31-23)19-6-5-17(24)11-20(19)33-12-15-7-8-27-21(25)10-15/h2-11,14,26H,12-13H2,1H3,(H,28,29,30,31) RQFBVVFCXVOINX-UHFFFAOYSA-N 170016 US9669034, 82 (rac)-4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazm-2-amine::US9669034, 83 4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 84 4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170016&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618586 373987171 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476513 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC=C)c1 InChI=1S/C20H20FN5O2S/c1-3-9-28-18-11-15(21)7-8-17(18)19-23-13-24-20(26-19)25-16-6-4-5-14(10-16)12-29(2,22)27/h3-8,10-11,13,22H,1,9,12H2,2H3,(H,23,24,25,26) NLCBKVLTHACFFE-UHFFFAOYSA-N 170036 US9669034, 85 (rac)-4-[4-Fluoro-2-(prop-2-en-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170036&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618588 373987172 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476515 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(cc2)C(F)(F)F)c1 InChI=1S/C25H21F4N5O2S/c1-37(30,35)14-17-3-2-4-20(11-17)33-24-32-15-31-23(34-24)21-10-9-19(26)12-22(21)36-13-16-5-7-18(8-6-16)25(27,28)29/h2-12,15,30H,13-14H2,1H3,(H,31,32,33,34) NMVJKGNENUYVOE-UHFFFAOYSA-N 170506 US9669034, 86 (rac)-4-(4-Fluoro-2-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170506&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618589 373987173 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476517 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(Cl)cc2)c1 InChI=1S/C24H21ClFN5O2S/c1-34(27,32)14-17-3-2-4-20(11-17)30-24-29-15-28-23(31-24)21-10-9-19(26)12-22(21)33-13-16-5-7-18(25)8-6-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) XAGZPNDRCQGPAH-UHFFFAOYSA-N 170507 US9669034, 87 (rac)-4-{2-[(4-Chlorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170507&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618590 373987174 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476519 CCOc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C19H20FN5O2S/c1-3-27-17-10-14(20)7-8-16(17)18-22-12-23-19(25-18)24-15-6-4-5-13(9-15)11-28(2,21)26/h4-10,12,21H,3,11H2,1-2H3,(H,22,23,24,25) XKDLBLCFRZLVPS-UHFFFAOYSA-N 170512 US9669034, 88 (rac)-4-(2-Ethoxy-4-fluorophenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170512&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618591 373987175 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476521 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cc(F)cc(c2)C(F)(F)F)c1 InChI=1S/C25H20F5N5O2S/c1-38(31,36)13-15-3-2-4-20(9-15)34-24-33-14-32-23(35-24)21-6-5-18(26)11-22(21)37-12-16-7-17(25(28,29)30)10-19(27)8-16/h2-11,14,31H,12-13H2,1H3,(H,32,33,34,35) YYRGTROMMSPUAJ-UHFFFAOYSA-N 170513 US9669034, 89 (rac)-4-(4-Fluoro-2-{[3-fluoro-5-(trifluoromethyl)benzyl]oxy}phenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazm-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170513&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618653 373987176 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476523 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cccc(F)c2)c1 InChI=1S/C24H21F2N5O2S/c1-34(27,32)14-17-5-3-7-20(11-17)30-24-29-15-28-23(31-24)21-9-8-19(26)12-22(21)33-13-16-4-2-6-18(25)10-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) YPAQXRURXUKFGB-UHFFFAOYSA-N 170515 US9669034, 90 (rac)-4-{4-Fluoro-2-[(3-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618654 373987177 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476525 CCCOc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C20H22FN5O2S/c1-3-9-28-18-11-15(21)7-8-17(18)19-23-13-24-20(26-19)25-16-6-4-5-14(10-16)12-29(2,22)27/h4-8,10-11,13,22H,3,9,12H2,1-2H3,(H,23,24,25,26) KSCZIASPGQACKX-UHFFFAOYSA-N 170517 US9669034, 91 (rac)-4-(4-Fluoro-2-propoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170517&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618655 373987178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476527 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cccc(Cl)c2)c1 InChI=1S/C24H21ClFN5O2S/c1-34(27,32)14-17-5-3-7-20(11-17)30-24-29-15-28-23(31-24)21-9-8-19(26)12-22(21)33-13-16-4-2-6-18(25)10-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) VVWVTEUZCVNOIF-UHFFFAOYSA-N 170518 US9669034, 92 (rac)-4-{2-[(3-Chlorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618656 373987179 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476529 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccon2)c1 InChI=1S/C21H19FN6O3S/c1-32(23,29)12-14-3-2-4-16(9-14)26-21-25-13-24-20(27-21)18-6-5-15(22)10-19(18)30-11-17-7-8-31-28-17/h2-10,13,23H,11-12H2,1H3,(H,24,25,26,27) AXLURCFSKIWPCA-UHFFFAOYSA-N 170519 US9669034, 93 (rac)-4-[4-Fluoro-2-(1,2-oxazol-3-ylmethoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618657 373987180 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476531 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cc(F)cc(Cl)c2)c1 InChI=1S/C24H20ClF2N5O2S/c1-35(28,33)13-15-3-2-4-20(9-15)31-24-30-14-29-23(32-24)21-6-5-18(26)11-22(21)34-12-16-7-17(25)10-19(27)8-16/h2-11,14,28H,12-13H2,1H3,(H,29,30,31,32) ODQNZRXLNIAATG-UHFFFAOYSA-N 170520 US9669034, 94 (rac)-4-{2-[(3-Chloro-5-fluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618719 373987181 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476533 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC(F)F)c1 InChI=1S/C19H18F3N5O2S/c1-30(23,28)10-12-3-2-4-14(7-12)26-19-25-11-24-18(27-19)15-6-5-13(20)8-16(15)29-9-17(21)22/h2-8,11,17,23H,9-10H2,1H3,(H,24,25,26,27) VYFFHUCKQLXQET-UHFFFAOYSA-N 170521 US9669034, 95 (rac)-4-[2-(2,2-Difluoroethoxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618720 373987182 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476535 Cc1cc(COc2cc(F)ccc2-c2ncnc(Nc3cccc(CS(C)(=N)=O)c3)n2)ccc1F InChI=1S/C25H23F2N5O2S/c1-16-10-17(6-9-22(16)27)13-34-23-12-19(26)7-8-21(23)24-29-15-30-25(32-24)31-20-5-3-4-18(11-20)14-35(2,28)33/h3-12,15,28H,13-14H2,1-2H3,(H,29,30,31,32) XCHXFUWJBRPMQZ-UHFFFAOYSA-N 174598 US9669034, 96 (rac)-4-{4-Fluoro-2-[(4-fluoro-3-methylbenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618722 373987183 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476537 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(F)c(Cl)c2)c1 InChI=1S/C24H20ClF2N5O2S/c1-35(28,33)13-16-3-2-4-18(9-16)31-24-30-14-29-23(32-24)19-7-6-17(26)11-22(19)34-12-15-5-8-21(27)20(25)10-15/h2-11,14,28H,12-13H2,1H3,(H,29,30,31,32) AYNIVSXDBPZHKI-UHFFFAOYSA-N 174850 US9669034, 97 (rac)-4-{2-[(3-Chloro-4-fluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174850&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618721 373987184 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476539 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cccc(c2)C#N)c1 InChI=1S/C25H21FN6O2S/c1-35(28,33)15-19-6-3-7-21(11-19)31-25-30-16-29-24(32-25)22-9-8-20(26)12-23(22)34-14-18-5-2-4-17(10-18)13-27/h2-12,16,28H,14-15H2,1H3,(H,29,30,31,32) KBOXUYIQIFCQGQ-UHFFFAOYSA-N 174971 US9669034, 98 (rac)-3-({5-Fluoro-2-[4-({3-[(S-methylsulfonimidoyl)methyl]phenyl}amino)-1,3,5-triazin-2-yl]phenoxy}methyl)benzonitrile Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174971&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618723 373987185 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476541 CC(=C)COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C21H22FN5O2S/c1-14(2)11-29-19-10-16(22)7-8-18(19)20-24-13-25-21(27-20)26-17-6-4-5-15(9-17)12-30(3,23)28/h4-10,13,23H,1,11-12H2,2-3H3,(H,24,25,26,27) GXPLQWLEZXXOPK-UHFFFAOYSA-N 175041 US9669034, 99 (rac)-4-{4-Fluoro-2-[(2-methylprop-2-en-1-yl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175041&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618724 373987186 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476543 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCCCC(F)(F)F)c1 InChI=1S/C21H21F4N5O2S/c1-33(26,31)12-14-4-2-5-16(10-14)29-20-28-13-27-19(30-20)17-7-6-15(22)11-18(17)32-9-3-8-21(23,24)25/h2,4-7,10-11,13,26H,3,8-9,12H2,1H3,(H,27,28,29,30) KZXWFUVWMYMLGT-UHFFFAOYSA-N 175881 US9669034, 100 (rac)-4-[4-Fluoro-2-(4,4,4-trifluorobutoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175881&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618808 373987187 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476545 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cc(F)cc(F)c2F)c1 InChI=1S/C24H19F4N5O2S/c1-36(29,34)12-14-3-2-4-18(7-14)32-24-31-13-30-23(33-24)19-6-5-16(25)10-21(19)35-11-15-8-17(26)9-20(27)22(15)28/h2-10,13,29H,11-12H2,1H3,(H,30,31,32,33) UOOJOAMMYFVKID-UHFFFAOYSA-N 175884 US9669034, 101 (rac)-4-{4-Fluoro-2-[(2,3,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175884&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618806 373987188 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519835 Nc1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C11H9N5/c12-11-14-5-3-9(16-11)8-6-15-10-7(8)2-1-4-13-10/h1-6H,(H,13,15)(H2,12,14,16) HQHSJJZIICGOIX-UHFFFAOYSA-N 50371404 MERIOLIN 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11637090 160850505 ZINC29135178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519836 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(=O)(=NC#N)C3CC3)c2)n1 InChI=1S/C21H19FN6O2S/c1-30-19-10-15(22)5-8-18(19)20-24-13-25-21(28-20)27-16-4-2-3-14(9-16)11-31(29,26-12-23)17-6-7-17/h2-5,8-10,13,17H,6-7,11H2,1H3,(H,24,25,27,28) DAXGPJQWYKFPPW-UHFFFAOYSA-N 179848 US9669034, 113 (rac)-[Cyclopropyl(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)oxido-λ6-sulfanylidene]cyanamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179848&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617809 373987198 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519842 CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1 DLPIYBKBHMZCJI-WBVHZDCISA-N 106950 US8592581, 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24983461 174009261 ZINC96177788 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519846 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccncc1 InChI=1S/C20H20N2O5/c1-22-7-4-12(16(26)10-22)18-13(23)8-14(24)19-15(25)9-17(27-20(18)19)11-2-5-21-6-3-11/h2-3,5-6,8-9,12,16,23-24,26H,4,7,10H2,1H3/t12-,16+/m0/s1 MPBLVVMMAMGCPJ-BLLLJJGKSA-N 50193089 CHEMBL3976972 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.5 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193089&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49770995 375076099 CHEMBL3976972 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519849 Clc1cnc(NC2CCCC2)cc1-c1cnc(N2CCOCC2)c(NCC2CCOCC2)c1 InChI=1S/C25H34ClN5O2/c26-22-17-28-24(30-20-3-1-2-4-20)14-21(22)19-13-23(27-15-18-5-9-32-10-6-18)25(29-16-19)31-7-11-33-12-8-31/h13-14,16-18,20,27H,1-12,15H2,(H,28,30) PFNXRFGEEJAJQC-UHFFFAOYSA-N 50193091 CHEMBL3911719 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3438 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193091&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 67635788 375076101 CHEMBL3911719 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519851 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.5 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519855 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 50229973 (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine::4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine::CHEMBL298445::[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229973&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CK7 2WEV,1PXO,4B9D 447961 104098225 CHEMBL298445 DB02833 ZINC02047389 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476547 C\C=C/COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C21H22FN5O2S/c1-3-4-10-29-19-12-16(22)8-9-18(19)20-24-14-25-21(27-20)26-17-7-5-6-15(11-17)13-30(2,23)28/h3-9,11-12,14,23H,10,13H2,1-2H3,(H,24,25,26,27)/b4-3- KDWXTPDMELXCLF-ARJAWSKDSA-N 176285 US9669034, 102 (rac)-4-{2-[(2Z)-But-2-en-1-yloxy]-4-fluorophenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176285&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618807 373987189 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476549 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cc(F)c(F)cc2F)c1 InChI=1S/C24H19F4N5O2S/c1-36(29,34)12-14-3-2-4-17(7-14)32-24-31-13-30-23(33-24)18-6-5-16(25)9-22(18)35-11-15-8-20(27)21(28)10-19(15)26/h2-10,13,29H,11-12H2,1H3,(H,30,31,32,33) SFVFBKQDFKQOSH-UHFFFAOYSA-N 176755 US9669034, 103 (rac)-4-{4-Fluoro-2-[(2,4,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176755&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618809 373987190 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476551 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cc(F)c(F)c(F)c2)c1 InChI=1S/C24H19F4N5O2S/c1-36(29,34)12-14-3-2-4-17(7-14)32-24-31-13-30-23(33-24)18-6-5-16(25)10-21(18)35-11-15-8-19(26)22(28)20(27)9-15/h2-10,13,29H,11-12H2,1H3,(H,30,31,32,33) NBZSIYZKQIXZPP-UHFFFAOYSA-N 176781 US9669034, 104 (rac)-4-{4-Fluoro-2-[(3,4,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176781&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618810 373987191 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476553 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)c(F)c(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H15F3N6O2S/c1-30-16-6-12(20)3-4-14(16)18-24-10-25-19(28-18)27-13-5-11(17(22)15(21)7-13)8-31(2,29)26-9-23/h3-7,10H,8H2,1-2H3,(H,24,25,27,28) RINAVKZGXKVFRD-UHFFFAOYSA-N 179392 US9669034, 105 (rac)-[(2,3-Difluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179392&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618811 373987192 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476555 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)c(F)c(CS(C)(=N)=O)c2)n1 InChI=1S/C18H16F3N5O2S/c1-28-15-6-11(19)3-4-13(15)17-23-9-24-18(26-17)25-12-5-10(8-29(2,22)27)16(21)14(20)7-12/h3-7,9,22H,8H2,1-2H3,(H,23,24,25,26) AARZZTJKBYIKBZ-UHFFFAOYSA-N 179442 US9669034, 106 (rac)-N-{3,4-Difluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179442&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617804 373987193 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476557 CCS(=O)(Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1)=NC#N InChI=1S/C20H19FN6O2S/c1-3-30(28,25-12-22)11-14-5-4-6-16(9-14)26-20-24-13-23-19(27-20)17-8-7-15(21)10-18(17)29-2/h4-10,13H,3,11H2,1-2H3,(H,23,24,26,27) LYDJRRHXAUQPTD-UHFFFAOYSA-N 179656 US9669034, 107 (rac)-[Ethyl(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)oxido-λ6-sulfanylidene]cyanamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179656&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617805 373987194 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476559 CCS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C19H20FN5O2S/c1-3-28(21,26)11-13-5-4-6-15(9-13)24-19-23-12-22-18(25-19)16-8-7-14(20)10-17(16)27-2/h4-10,12,21H,3,11H2,1-2H3,(H,22,23,24,25) AQRMHECVRYEXOP-UHFFFAOYSA-N 179658 US9669034, 108 (rac)-N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine::US9669034, 109 N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer1::US9669034, 110 N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179658&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617806 373987195 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476561 CCS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C19H20FN5O2S/c1-3-28(21,26)11-13-5-4-6-15(9-13)24-19-23-12-22-18(25-19)16-8-7-14(20)10-17(16)27-2/h4-10,12,21H,3,11H2,1-2H3,(H,22,23,24,25) AQRMHECVRYEXOP-UHFFFAOYSA-N 179658 US9669034, 108 (rac)-N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine::US9669034, 109 N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer1::US9669034, 110 N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179658&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617806 373987195 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476562 CCS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C19H20FN5O2S/c1-3-28(21,26)11-13-5-4-6-15(9-13)24-19-23-12-22-18(25-19)16-8-7-14(20)10-17(16)27-2/h4-10,12,21H,3,11H2,1-2H3,(H,22,23,24,25) AQRMHECVRYEXOP-UHFFFAOYSA-N 179658 US9669034, 108 (rac)-N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine::US9669034, 109 N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer1::US9669034, 110 N-{3-[(S-ethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179658&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617806 373987195 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476563 COc1cc(F)ccc1-c1ncnc(Nc2cc(C)cc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C20H19FN6O2S/c1-13-6-14(10-30(3,28)25-11-22)8-16(7-13)26-20-24-12-23-19(27-20)17-5-4-15(21)9-18(17)29-2/h4-9,12H,10H2,1-3H3,(H,23,24,26,27) XJMDRRFQIHSBHL-UHFFFAOYSA-N 179686 US9669034, 111 (rac)-[(3-{[4-(4-Fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}-5-methylbenzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179686&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262313 373987196 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519856 CC(C)Oc1ccc(F)cc1-c1cc(NC(=O)[C@@H]2CCCNC2)ncc1Cl InChI=1S/C20H23ClFN3O2/c1-12(2)27-18-6-5-14(22)8-16(18)15-9-19(24-11-17(15)21)25-20(26)13-4-3-7-23-10-13/h5-6,8-9,11-13,23H,3-4,7,10H2,1-2H3,(H,24,25,26)/t13-/m1/s1 WUIYYLQXGFFWTL-CYBMUJFWSA-N 50193092 CHEMBL3948080 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193092&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 50991506 375076102 CHEMBL3948080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519865 COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 InChI=1S/C21H24FN3O3/c1-13(26)24-17-5-3-4-15(10-17)21(27)25-20-11-14(8-9-23-20)18-7-6-16(22)12-19(18)28-2/h6-9,11-12,15,17H,3-5,10H2,1-2H3,(H,24,26)(H,23,25,27)/t15-,17+/m0/s1 QNWXRLPZIFMTBK-DOTOQJQBSA-N 164883 US9067888, 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 53373586 311419854 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519866 Fc1ccc(nc1NCC1CCOCC1)-c1cc(NC(=O)[C@@H]2CCCNC2)ncc1Cl InChI=1S/C22H27ClFN5O2/c23-17-13-26-20(29-22(30)15-2-1-7-25-12-15)10-16(17)19-4-3-18(24)21(28-19)27-11-14-5-8-31-9-6-14/h3-4,10,13-15,25H,1-2,5-9,11-12H2,(H,27,28)(H,26,29,30)/t15-/m1/s1 OETJRQWLHMSDMD-OAHLLOKOSA-N 50193096 CHEMBL3977324 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193096&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 67222084 375076106 CHEMBL3977324 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519873 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)n1 InChI=1S/C26H36N6O/c1-17(2)25-22-16-18(4-9-24(22)31-32(25)3)23-10-13-27-26(30-23)29-20-7-5-19(6-8-20)28-21-11-14-33-15-12-21/h4,9-10,13,16-17,19-21,28H,5-8,11-12,14-15H2,1-3H3,(H,27,29,30)/t19-,20- LHIUZPIDLZYPRL-MXVIHJGJSA-N 50193097 CHEMBL3940387 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193097&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 78357764 375076107 CHEMBL3940387 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519880 CCCOc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C14H15N5O/c1-2-7-20-11-4-6-16-13-12(11)9(8-18-13)10-3-5-17-14(15)19-10/h3-6,8H,2,7H2,1H3,(H,16,18)(H2,15,17,19) ZHMRPXZRUZLCNL-UHFFFAOYSA-N 50371400 MERIOLIN 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371400&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search MHR 3BHU 23727982 160850501 DB08182 ZINC16052674 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519881 Nc1nccc(n1)-c1c[nH]c2nccc(O)c12 InChI=1S/C11H9N5O/c12-11-14-3-1-7(16-11)6-5-15-10-9(6)8(17)2-4-13-10/h1-5H,(H2,12,14,16)(H2,13,15,17) JYGNOLIKBUTZNC-UHFFFAOYSA-N 50371403 MERIOLIN 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801699 160850504 ZINC29135124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519889 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1 InChI=1S/C21H21NO6/c1-22-7-6-13(17(27)10-22)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-2-4-12(23)5-3-11/h2-5,8-9,13,17,23-25,27H,6-7,10H2,1H3/t13-,17+/m0/s1 KONXUCIJNQYNNP-SUMWQHHRSA-N 50193088 CHEMBL3906282 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.6 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193088&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49770990 375076098 CHEMBL3906282 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519890 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(Br)cc1 InChI=1S/C21H20BrNO5/c1-23-7-6-13(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-2-4-12(22)5-3-11/h2-5,8-9,13,17,24-25,27H,6-7,10H2,1H3/t13-,17+/m0/s1 SASCFBGSAVCXNS-SUMWQHHRSA-N 50193099 CHEMBL3915260 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.5 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193099&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49770987 375076109 CHEMBL3915260 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519891 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(F)cc1 InChI=1S/C21H20FNO5/c1-23-7-6-13(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-2-4-12(22)5-3-11/h2-5,8-9,13,17,24-25,27H,6-7,10H2,1H3/t13-,17+/m0/s1 GBTFAVMORZGOBX-SUMWQHHRSA-N 50193101 CHEMBL3896233 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.1 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193101&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49770984 375076111 CHEMBL3896233 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519893 CCCP(O)(=O)Cc1cccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)c1 InChI=1S/C27H28N3O3P/c1-2-15-34(31,32)19-22-11-8-12-23(16-22)30-27-17-25(28-20-29-27)24-13-6-7-14-26(24)33-18-21-9-4-3-5-10-21/h3-14,16-17,20H,2,15,18-19H2,1H3,(H,31,32)(H,28,29,30) IIZHHHNHDPJHJK-UHFFFAOYSA-N 50013492 CHEMBL3264159 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 142 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013492&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86580300 103925626 CHEMBL3264159 ZINC26000955 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519898 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cccc(F)c2)c1 InChI=1S/C24H21F2N5O2S/c1-34(27,32)14-17-5-3-7-20(11-17)30-24-29-15-28-23(31-24)21-9-8-19(26)12-22(21)33-13-16-4-2-6-18(25)10-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) YPAQXRURXUKFGB-UHFFFAOYSA-N 170515 US9669034, 90 (rac)-4-{4-Fluoro-2-[(3-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618654 373987177 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519899 CS(=O)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccccc2)c1 InChI=1S/C24H21FN4O3S/c1-33(30,31)15-18-8-5-9-20(12-18)28-24-27-16-26-23(29-24)21-11-10-19(25)13-22(21)32-14-17-6-3-2-4-7-17/h2-13,16H,14-15H2,1H3,(H,26,27,28,29) LWOIOAVZAUIQIB-UHFFFAOYSA-N 50193102 CHEMBL3921344 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193102&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66571226 375076112 CHEMBL3921344 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519916 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476565 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC(=C)CO)c1 InChI=1S/C21H22FN5O3S/c1-14(10-28)11-30-19-9-16(22)6-7-18(19)20-24-13-25-21(27-20)26-17-5-3-4-15(8-17)12-31(2,23)29/h3-9,13,23,28H,1,10-12H2,2H3,(H,24,25,26,27) ISLASAXDUXLSON-UHFFFAOYSA-N 179847 US9669034, 112 (rac)-2-({5-Fluoro-2-[4-({3-[(S-methylsulfonimidoyl)methyl]phenyl}amino)-1,3,5-triazin-2-yl]phenoxy}methyl)prop-2-en-1-ol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179847&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617808 373987197 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476567 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(=O)(=NC#N)C3CC3)c2)n1 InChI=1S/C21H19FN6O2S/c1-30-19-10-15(22)5-8-18(19)20-24-13-25-21(28-20)27-16-4-2-3-14(9-16)11-31(29,26-12-23)17-6-7-17/h2-5,8-10,13,17H,6-7,11H2,1H3,(H,24,25,27,28) DAXGPJQWYKFPPW-UHFFFAOYSA-N 179848 US9669034, 113 (rac)-[Cyclopropyl(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)oxido-λ6-sulfanylidene]cyanamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=179848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=179848&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617809 373987198 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519928 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519929 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519932 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519933 CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1Cl)C(F)(F)F InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1 MRPGRAKIAJJGMM-OCCSQVGLSA-N 50193104 CHEMBL3905910 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193104&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 67409219 375076114 CHEMBL3905910 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519939 NCCCNc1cc(c(Cl)cn1)-c1cncc(NCC2CCOCC2)c1 InChI=1S/C19H26ClN5O/c20-18-13-25-19(23-5-1-4-21)9-17(18)15-8-16(12-22-11-15)24-10-14-2-6-26-7-3-14/h8-9,11-14,24H,1-7,10,21H2,(H,23,25) TUIHLGIQAFUWDM-UHFFFAOYSA-N 50193105 CHEMBL3897908 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1858 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193105&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 67630488 375076115 CHEMBL3897908 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519940 OCCNc1cc(c(Cl)cn1)-c1cncc(NCc2cccc(F)c2)c1 InChI=1S/C19H18ClFN4O/c20-18-12-25-19(23-4-5-26)8-17(18)14-7-16(11-22-10-14)24-9-13-2-1-3-15(21)6-13/h1-3,6-8,10-12,24,26H,4-5,9H2,(H,23,25) HFDKKSOKCNZLGJ-UHFFFAOYSA-N 50193106 CHEMBL3938592 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193106&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134148638 375076116 CHEMBL3938592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519942 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519944 CS(=O)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccnc(F)c2)c1 InChI=1S/C23H19F2N5O3S/c1-34(31,32)13-16-3-2-4-18(9-16)29-23-28-14-27-22(30-23)19-6-5-17(24)11-20(19)33-12-15-7-8-26-21(25)10-15/h2-11,14H,12-13H2,1H3,(H,27,28,29,30) DTTGEKGDXFLMIL-UHFFFAOYSA-N 50193103 CHEMBL3957795 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193103&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66576054 375076113 CHEMBL3957795 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519947 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519953 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 InChI=1S/C21H21NO5/c1-22-8-7-13(17(26)11-22)19-14(23)9-15(24)20-16(25)10-18(27-21(19)20)12-5-3-2-4-6-12/h2-6,9-10,13,17,23-24,26H,7-8,11H2,1H3/t13-,17+/m0/s1 PGWURUYAKNYOPM-SUMWQHHRSA-N 50193100 CHEMBL3898028 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193100&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49770981 375076110 CHEMBL3898028 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519956 COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1 InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22) GGQCIOOSELPMBB-UHFFFAOYSA-N 50013510 CHEMBL3263773 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013510&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25104564 242058283 CHEMBL3263773 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519958 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1)C(F)(F)F InChI=1S/C22H20F3NO5/c1-26-7-6-13(17(30)10-26)19-14(27)8-15(28)20-16(29)9-18(31-21(19)20)11-2-4-12(5-3-11)22(23,24)25/h2-5,8-9,13,17,27-28,30H,6-7,10H2,1H3/t13-,17+/m0/s1 DVFJGRYENKMQBH-SUMWQHHRSA-N 50193098 CHEMBL3897316 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193098&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49770989 375076108 CHEMBL3897316 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519967 OCCNc1cc(c(Cl)cn1)-c1cnc(N2CCOCC2)c(NCc2cccc(F)c2)c1 InChI=1S/C23H25ClFN5O2/c24-20-15-28-22(26-4-7-31)12-19(20)17-11-21(27-13-16-2-1-3-18(25)10-16)23(29-14-17)30-5-8-32-9-6-30/h1-3,10-12,14-15,27,31H,4-9,13H2,(H,26,28) JWMNGINJCKZUHW-UHFFFAOYSA-N 50193107 CHEMBL3948451 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6917 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193107&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 67642003 375076117 CHEMBL3948451 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519968 CS(=O)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cccc(c2)C(F)(F)F)c1 InChI=1S/C25H20F4N4O3S/c1-37(34,35)14-17-5-3-7-20(11-17)32-24-31-15-30-23(33-24)21-9-8-19(26)12-22(21)36-13-16-4-2-6-18(10-16)25(27,28)29/h2-12,15H,13-14H2,1H3,(H,30,31,32,33) LHEDETRRIJTKNJ-UHFFFAOYSA-N 50193094 CHEMBL3930310 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193094&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66575811 375076104 CHEMBL3930310 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519970 COc1cc(F)ccc1-c1ccnc(NC(=O)[C@@H]2CC[C@@H](C2)NC(C)=O)c1 InChI=1S/C20H22FN3O3/c1-12(25)23-16-5-3-14(9-16)20(26)24-19-10-13(7-8-22-19)17-6-4-15(21)11-18(17)27-2/h4,6-8,10-11,14,16H,3,5,9H2,1-2H3,(H,23,25)(H,22,24,26)/t14-,16+/m1/s1 FUMJKSZLZJFCAQ-ZBFHGGJFSA-N 50193095 CHEMBL3961341 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193095&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 53380162 375076105 CHEMBL3961341 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519978 COc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C12H11N5O/c1-18-9-3-5-14-11-10(9)7(6-16-11)8-2-4-15-12(13)17-8/h2-6H,1H3,(H,14,16)(H2,13,15,17) GGEWEQJWGGJUHO-UHFFFAOYSA-N 50371402 MERIOLIN 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search MFR 3BHT,7A5B 23727981 160850503 DB08178 ZINC16052675 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519983 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(C=C)cc1 InChI=1S/C23H23NO5/c1-3-13-4-6-14(7-5-13)20-11-18(27)22-17(26)10-16(25)21(23(22)29-20)15-8-9-24(2)12-19(15)28/h3-7,10-11,15,19,25-26,28H,1,8-9,12H2,2H3/t15-,19+/m0/s1 FULPMHLTPCRTKC-HNAYVOBHSA-N 50193108 CHEMBL3985045 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.5 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193108&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49771003 375076118 CHEMBL3985045 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519984 COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1 InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38) XLSYZSRXVVCHLS-UHFFFAOYSA-N 50193093 RGB-286638 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193093&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11285002 375076103 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519985 Cc1c(sc(=O)n1C)-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C19H22N6OS/c1-13-17(27-19(26)24(13)2)16-7-8-21-18(23-16)22-14-3-5-15(6-4-14)25-11-9-20-10-12-25/h3-8,20H,9-12H2,1-2H3,(H,21,22,23) CGGMDMYBCWDOLZ-UHFFFAOYSA-N 81441 CDK Inhibitor, 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.400000 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81441&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11257553 131342015 ZINC58650237 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519987 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1F InChI=1S/C21H20FNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 MADUTGUALSLNOW-YVEFUNNKSA-N 50193109 CHEMBL3924246 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.8 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193109&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 44481738 375076119 CHEMBL3924246 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519989 CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3/t12-,14+/m1/s1 QLUYMIVVAYRECT-OCCSQVGLSA-N 50193086 CHEMBL3969723 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 23643976 375076096 CHEMBL3969723 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519993 C[C@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11+,29?/m0/s1 UELYDGOOJPRWGF-DUFANNBHSA-N 50193085 CHEMBL3925525 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193085&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134140883 375076095 CHEMBL3925525 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50519996 COc1ccnc2n(C)cc(-c3ccnc(N)n3)c12 InChI=1S/C13H13N5O/c1-18-7-8(9-3-5-16-13(14)17-9)11-10(19-2)4-6-15-12(11)18/h3-7H,1-2H3,(H2,14,16,17) CPQCGVRZSBLZLT-UHFFFAOYSA-N 50371410 MERIOLIN 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24801698 160850511 ZINC29135067 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476372 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3OC(F)(F)Oc23)c1 InChI=1S/C21H19F2N5O5S/c1-3-31-20(29)28-34(2,30)11-13-6-4-7-14(10-13)26-19-25-12-24-18(27-19)15-8-5-9-16-17(15)33-21(22,23)32-16/h4-10,12H,3,11H2,1-2H3,(H,24,25,26,27) YTSZUHMRVZVDQB-UHFFFAOYSA-N 168398 US9669034, 18 (rac)-Ethyl[(3-{[4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168398&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262079 373987128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476374 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3OC(F)(F)Oc23)c1 InChI=1S/C18H15F2N5O3S/c1-29(21,26)9-11-4-2-5-12(8-11)24-17-23-10-22-16(25-17)13-6-3-7-14-15(13)28-18(19,20)27-14/h2-8,10,21H,9H2,1H3,(H,22,23,24,25) RATJRCPZGZBDCR-UHFFFAOYSA-N 168401 US9669034, 19 (rac)-4-(2,2-Difluoro-1,3-benzodioxol-4-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168401&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240024 373987129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476376 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cc(F)ccc2OC)c1 InChI=1S/C21H22FN5O4S/c1-4-31-21(28)27-32(3,29)12-14-6-5-7-16(10-14)25-20-24-13-23-19(26-20)17-11-15(22)8-9-18(17)30-2/h5-11,13H,4,12H2,1-3H3,(H,23,24,25,26) DXGZOUIOMARMEM-UHFFFAOYSA-N 168402 US9669034, 20 (rac)-Ethyl[(3-{[4-(5-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618139 373987130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476378 COc1ccc(F)cc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-7-6-13(19)9-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) WCEPZJNVUHQRBI-UHFFFAOYSA-N 168403 US9669034, 21 (rac)-4-(5-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 22 4-(5-Fluoro-2-methoxyplienyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 23 4-(5-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618140 373987131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476380 COc1ccc(F)cc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-7-6-13(19)9-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) WCEPZJNVUHQRBI-UHFFFAOYSA-N 168403 US9669034, 21 (rac)-4-(5-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 22 4-(5-Fluoro-2-methoxyplienyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 23 4-(5-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618140 373987131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476382 COc1ccc(F)cc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-7-6-13(19)9-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) WCEPZJNVUHQRBI-UHFFFAOYSA-N 168403 US9669034, 21 (rac)-4-(5-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 22 4-(5-Fluoro-2-methoxyplienyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 23 4-(5-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618140 373987131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476384 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(C)=O)c2)n1 InChI=1S/C20H20FN5O3S/c1-13(27)26-30(3,28)11-14-5-4-6-16(9-14)24-20-23-12-22-19(25-20)17-8-7-15(21)10-18(17)29-2/h4-10,12H,11H2,1-3H3,(H,22,23,24,25) JGZDVNNQEDSILI-UHFFFAOYSA-N 168406 US9669034, 24 (rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618199 373987132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476386 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccccc2OC)c1 InChI=1S/C21H23N5O4S/c1-4-30-21(27)26-31(3,28)13-15-8-7-9-16(12-15)24-20-23-14-22-19(25-20)17-10-5-6-11-18(17)29-2/h5-12,14H,4,13H2,1-3H3,(H,22,23,24,25) UIULZUUYDBRTOL-UHFFFAOYSA-N 168407 US9669034, 25 (rac)-Ethyl[(3-{[4-(2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618200 373987133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476388 COc1ccccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H19N5O2S/c1-25-16-9-4-3-8-15(16)17-20-12-21-18(23-17)22-14-7-5-6-13(10-14)11-26(2,19)24/h3-10,12,19H,11H2,1-2H3,(H,20,21,22,23) WKMLBAKTAZIKEE-UHFFFAOYSA-N 168408 US9669034, 26 (rac)-4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 27 4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 28 4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618201 373987134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476390 COc1ccccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H19N5O2S/c1-25-16-9-4-3-8-15(16)17-20-12-21-18(23-17)22-14-7-5-6-13(10-14)11-26(2,19)24/h3-10,12,19H,11H2,1-2H3,(H,20,21,22,23) WKMLBAKTAZIKEE-UHFFFAOYSA-N 168408 US9669034, 26 (rac)-4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 27 4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 28 4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618201 373987134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476392 COc1ccccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H19N5O2S/c1-25-16-9-4-3-8-15(16)17-20-12-21-18(23-17)22-14-7-5-6-13(10-14)11-26(2,19)24/h3-10,12,19H,11H2,1-2H3,(H,20,21,22,23) WKMLBAKTAZIKEE-UHFFFAOYSA-N 168408 US9669034, 26 (rac)-4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 27 4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 28 4-(2-Methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618201 373987134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476394 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCCOc23)c1 InChI=1S/C23H25N5O4S/c1-3-31-23(29)28-33(2,30)14-16-7-4-10-18(13-16)26-22-25-15-24-21(27-22)19-11-5-8-17-9-6-12-32-20(17)19/h4-5,7-8,10-11,13,15H,3,6,9,12,14H2,1-2H3,(H,24,25,26,27) JUHYCKGWWIAUOR-UHFFFAOYSA-N 168411 US9669034, 29 (rac)-Ethyl[(3-{[4-(3,4-dihydro-2H-chromen-8-yl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168411&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262556 373987135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476396 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCCOc23)c1 InChI=1S/C20H21N5O2S/c1-28(21,26)12-14-5-2-8-16(11-14)24-20-23-13-22-19(25-20)17-9-3-6-15-7-4-10-27-18(15)17/h2-3,5-6,8-9,11,13,21H,4,7,10,12H2,1H3,(H,22,23,24,25) ILVMBMOIUKZZRA-UHFFFAOYSA-N 168412 US9669034, 30 (rac)-4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 31 4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 32 4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240038 373987136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476398 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCCOc23)c1 InChI=1S/C20H21N5O2S/c1-28(21,26)12-14-5-2-8-16(11-14)24-20-23-13-22-19(25-20)17-9-3-6-15-7-4-10-27-18(15)17/h2-3,5-6,8-9,11,13,21H,4,7,10,12H2,1H3,(H,22,23,24,25) ILVMBMOIUKZZRA-UHFFFAOYSA-N 168412 US9669034, 30 (rac)-4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 31 4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 32 4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240038 373987136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476400 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCCOc23)c1 InChI=1S/C20H21N5O2S/c1-28(21,26)12-14-5-2-8-16(11-14)24-20-23-13-22-19(25-20)17-9-3-6-15-7-4-10-27-18(15)17/h2-3,5-6,8-9,11,13,21H,4,7,10,12H2,1H3,(H,22,23,24,25) ILVMBMOIUKZZRA-UHFFFAOYSA-N 168412 US9669034, 30 (rac)-4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 31 4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 32 4-(3,4-Dihydro-2H-chromen-8-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240038 373987136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476402 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCOc23)c1 InChI=1S/C22H23N5O4S/c1-3-30-22(28)27-32(2,29)13-15-6-4-8-17(12-15)25-21-24-14-23-20(26-21)18-9-5-7-16-10-11-31-19(16)18/h4-9,12,14H,3,10-11,13H2,1-2H3,(H,23,24,25,26) YMDMWISLONYWRL-UHFFFAOYSA-N 168418 US9669034, 33 (rac)-Ethyl[(3-{[4-(2,3-dihydro-1-benzofuran-7-yl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168418&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618202 373987137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476404 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCOc23)c1 InChI=1S/C19H19N5O2S/c1-27(20,25)11-13-4-2-6-15(10-13)23-19-22-12-21-18(24-19)16-7-3-5-14-8-9-26-17(14)16/h2-7,10,12,20H,8-9,11H2,1H3,(H,21,22,23,24) HSODISFNJMBQLW-UHFFFAOYSA-N 168420 US9669034, 34 (rac)-4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 35 4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 36 4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240015 373987138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476406 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCOc23)c1 InChI=1S/C19H19N5O2S/c1-27(20,25)11-13-4-2-6-15(10-13)23-19-22-12-21-18(24-19)16-7-3-5-14-8-9-26-17(14)16/h2-7,10,12,20H,8-9,11H2,1H3,(H,21,22,23,24) HSODISFNJMBQLW-UHFFFAOYSA-N 168420 US9669034, 34 (rac)-4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 35 4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 36 4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240015 373987138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476408 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3CCOc23)c1 InChI=1S/C19H19N5O2S/c1-27(20,25)11-13-4-2-6-15(10-13)23-19-22-12-21-18(24-19)16-7-3-5-14-8-9-26-17(14)16/h2-7,10,12,20H,8-9,11H2,1H3,(H,21,22,23,24) HSODISFNJMBQLW-UHFFFAOYSA-N 168420 US9669034, 34 (rac)-4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 35 4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 36 4-(2,3-Dihydro-1-benzofuran-7-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240015 373987138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476410 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3OCCOc23)c1 InChI=1S/C22H23N5O5S/c1-3-30-22(28)27-33(2,29)13-15-6-4-7-16(12-15)25-21-24-14-23-20(26-21)17-8-5-9-18-19(17)32-11-10-31-18/h4-9,12,14H,3,10-11,13H2,1-2H3,(H,23,24,25,26) HSNCIMRSYIDBOX-UHFFFAOYSA-N 168425 US9669034, 37 (rac)-Ethyl[(3-{[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxide-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168425&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618203 373987139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476412 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3OCCOc23)c1 InChI=1S/C19H19N5O3S/c1-28(20,25)11-13-4-2-5-14(10-13)23-19-22-12-21-18(24-19)15-6-3-7-16-17(15)27-9-8-26-16/h2-7,10,12,20H,8-9,11H2,1H3,(H,21,22,23,24) YXCJYVQJSBEOPI-UHFFFAOYSA-N 168426 US9669034, 38 (rac)-4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 39 4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 40 4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618204 373987140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476414 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3OCCOc23)c1 InChI=1S/C19H19N5O3S/c1-28(20,25)11-13-4-2-5-14(10-13)23-19-22-12-21-18(24-19)15-6-3-7-16-17(15)27-9-8-26-16/h2-7,10,12,20H,8-9,11H2,1H3,(H,21,22,23,24) YXCJYVQJSBEOPI-UHFFFAOYSA-N 168426 US9669034, 38 (rac)-4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 39 4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 40 4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618204 373987140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476416 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc3OCCOc23)c1 InChI=1S/C19H19N5O3S/c1-28(20,25)11-13-4-2-5-14(10-13)23-19-22-12-21-18(24-19)15-6-3-7-16-17(15)27-9-8-26-16/h2-7,10,12,20H,8-9,11H2,1H3,(H,21,22,23,24) YXCJYVQJSBEOPI-UHFFFAOYSA-N 168426 US9669034, 38 (rac)-4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 39 4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 40 4-(2,3-Dihydro-1,4-benzodioxin-5-yl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618204 373987140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476418 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC)c2)n1 InChI=1S/C19H20FN5O2S/c1-21-28(3,26)11-13-5-4-6-15(9-13)24-19-23-12-22-18(25-19)16-8-7-14(20)10-17(16)27-2/h4-10,12H,11H2,1-3H3,(H,22,23,24,25) OWPCQFQPJGAQSP-UHFFFAOYSA-N 168429 US9669034, 41 (rac)-N-{3-[(N,S-Dimethylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168429&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89240031 373987141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476420 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccccc2OCc2ccc(F)cc2)c1 InChI=1S/C27H26FN5O4S/c1-3-36-27(34)33-38(2,35)17-20-7-6-8-22(15-20)31-26-30-18-29-25(32-26)23-9-4-5-10-24(23)37-16-19-11-13-21(28)14-12-19/h4-15,18H,3,16-17H2,1-2H3,(H,29,30,31,32) WSZWRAOUSCHIJV-UHFFFAOYSA-N 168432 US9669034, 42 (rac)-Ethyl[{3-[(4-{2-[(4-fluorobenzyl)oxy]phenyl}-1,3,5-triazin-2-yl)amino]benzyl}(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168432&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618256 373987142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476422 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccccc2OCc2ccc(F)cc2)c1 InChI=1S/C24H22FN5O2S/c1-33(26,31)15-18-5-4-6-20(13-18)29-24-28-16-27-23(30-24)21-7-2-3-8-22(21)32-14-17-9-11-19(25)12-10-17/h2-13,16,26H,14-15H2,1H3,(H,27,28,29,30) LOBYSFZFNMZNHN-UHFFFAOYSA-N 168443 US9669034, 43 (rac)-4-{2-[(4-Fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168443&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618257 373987143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476424 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NS(C)(=O)=O)c2)n1 InChI=1S/C19H20FN5O4S2/c1-29-17-10-14(20)7-8-16(17)18-21-12-22-19(24-18)23-15-6-4-5-13(9-15)11-30(2,26)25-31(3,27)28/h4-10,12H,11H2,1-3H3,(H,21,22,23,24) BRMHHHVFGCBBPI-UHFFFAOYSA-N 168445 US9669034, 44 (rac)-N-[(3-{[4-(4-Fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]methanesulfonamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262519 373987144 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476426 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cccc(Cl)c2OC)c1 InChI=1S/C21H22ClN5O4S/c1-4-31-21(28)27-32(3,29)12-14-7-5-8-15(11-14)25-20-24-13-23-19(26-20)16-9-6-10-17(22)18(16)30-2/h5-11,13H,4,12H2,1-3H3,(H,23,24,25,26) ZHHDFJPKLAWMOG-UHFFFAOYSA-N 168446 US9669034, 45 (rac)-Ethyl[(3-{[4-(3-chloro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 820 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262496 373987145 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476428 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2cc(F)ccc2OCC2CCOCC2)c1 InChI=1S/C26H30FN5O5S/c1-3-36-26(33)32-38(2,34)16-19-5-4-6-21(13-19)30-25-29-17-28-24(31-25)22-14-20(27)7-8-23(22)37-15-18-9-11-35-12-10-18/h4-8,13-14,17-18H,3,9-12,15-16H2,1-2H3,(H,28,29,30,31) FZUBZMRGEZULOV-UHFFFAOYSA-N 168447 US9669034, 46 (rac)-Ethyl{[3-({4-[5-fluoro-2-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]-1,3,5-triazin-2-yl}amino)benzyl](methyl)oxido-λ6-sulfanylidene}carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168447&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262520 373987146 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476430 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccccc2Oc2ccccc2)c1 InChI=1S/C26H25N5O4S/c1-3-34-26(32)31-36(2,33)17-19-10-9-11-20(16-19)29-25-28-18-27-24(30-25)22-14-7-8-15-23(22)35-21-12-5-4-6-13-21/h4-16,18H,3,17H2,1-2H3,(H,27,28,29,30) PCNJDEVABKGFEE-UHFFFAOYSA-N 168448 US9669034, 47 (rac)-Ethyl[methyl(oxido)(3-{[4-(2-phenoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168448&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89262078 373987147 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476432 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H17FN6O2S/c1-28-17-9-14(20)6-7-16(17)18-22-12-23-19(26-18)25-15-5-3-4-13(8-15)10-29(2,27)24-11-21/h3-9,12H,10H2,1-2H3,(H,22,23,25,26) HZWBTTMSSDOWKE-UHFFFAOYSA-N 168449 US9669034, 48 (rac)-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide::US9669034, 49 [(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide;enantiomer1::US9669034, 50 [(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617807 373987148 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476434 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H17FN6O2S/c1-28-17-9-14(20)6-7-16(17)18-22-12-23-19(26-18)25-15-5-3-4-13(8-15)10-29(2,27)24-11-21/h3-9,12H,10H2,1-2H3,(H,22,23,25,26) HZWBTTMSSDOWKE-UHFFFAOYSA-N 168449 US9669034, 48 (rac)-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide::US9669034, 49 [(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide;enantiomer1::US9669034, 50 [(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617807 373987148 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476436 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H17FN6O2S/c1-28-17-9-14(20)6-7-16(17)18-22-12-23-19(26-18)25-15-5-3-4-13(8-15)10-29(2,27)24-11-21/h3-9,12H,10H2,1-2H3,(H,22,23,25,26) HZWBTTMSSDOWKE-UHFFFAOYSA-N 168449 US9669034, 48 (rac)-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide::US9669034, 49 [(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide;enantiomer1::US9669034, 50 [(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]cyanamide;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71617807 373987148 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476438 CCOC(=O)N=S(C)(=O)Cc1cc(F)cc(Nc2ncnc(n2)-c2ccc(F)cc2OC)c1 InChI=1S/C21H21F2N5O4S/c1-4-32-21(29)28-33(3,30)11-13-7-15(23)9-16(8-13)26-20-25-12-24-19(27-20)17-6-5-14(22)10-18(17)31-2/h5-10,12H,4,11H2,1-3H3,(H,24,25,26,27) MMDJQSYPCUVOEL-UHFFFAOYSA-N 168457 US9669034, 51 (rac)-Ethyl[(3-fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168457&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618328 373987149 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476440 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)cc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17F2N5O2S/c1-27-16-8-12(19)3-4-15(16)17-22-10-23-18(25-17)24-14-6-11(5-13(20)7-14)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) DLZIASJRLRECRS-UHFFFAOYSA-N 168458 US9669034, 52 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 53 4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 54 4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618329 373987150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476442 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)cc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17F2N5O2S/c1-27-16-8-12(19)3-4-15(16)17-22-10-23-18(25-17)24-14-6-11(5-13(20)7-14)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) DLZIASJRLRECRS-UHFFFAOYSA-N 168458 US9669034, 52 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 53 4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 54 4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618329 373987150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476444 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)cc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17F2N5O2S/c1-27-16-8-12(19)3-4-15(16)17-22-10-23-18(25-17)24-14-6-11(5-13(20)7-14)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) DLZIASJRLRECRS-UHFFFAOYSA-N 168458 US9669034, 52 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 53 4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 54 4-(4-Fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618329 373987150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476446 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC2CCCCC2)c1 InChI=1S/C24H28FN5O2S/c1-33(26,31)15-18-8-5-9-20(12-18)29-24-28-16-27-23(30-24)21-11-10-19(25)13-22(21)32-14-17-6-3-2-4-7-17/h5,8-13,16-17,26H,2-4,6-7,14-15H2,1H3,(H,27,28,29,30) CPKDZRYUNSDUDC-UHFFFAOYSA-N 168461 US9669034, 55 (rac)-4-[2-(Cyclohexylmethoxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168461&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89239843 373987151 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476448 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(F)cc2)c1 InChI=1S/C24H21F2N5O2S/c1-34(27,32)14-17-3-2-4-20(11-17)30-24-29-15-28-23(31-24)21-10-9-19(26)12-22(21)33-13-16-5-7-18(25)8-6-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) MBJQXRJIUIQIGV-UHFFFAOYSA-N 168463 US9669034, 56 (rac)-4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 56.a 4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 56.b 4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618331 373987152 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476450 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(F)cc2)c1 InChI=1S/C24H21F2N5O2S/c1-34(27,32)14-17-3-2-4-20(11-17)30-24-29-15-28-23(31-24)21-10-9-19(26)12-22(21)33-13-16-5-7-18(25)8-6-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) MBJQXRJIUIQIGV-UHFFFAOYSA-N 168463 US9669034, 56 (rac)-4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 56.a 4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 56.b 4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618331 373987152 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476452 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(F)cc2)c1 InChI=1S/C24H21F2N5O2S/c1-34(27,32)14-17-3-2-4-20(11-17)30-24-29-15-28-23(31-24)21-10-9-19(26)12-22(21)33-13-16-5-7-18(25)8-6-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) MBJQXRJIUIQIGV-UHFFFAOYSA-N 168463 US9669034, 56 (rac)-4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 56.a 4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 56.b 4-{4-Fluoro-2-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618331 373987152 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476454 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCCC2CCOCC2)c1 InChI=1S/C24H28FN5O3S/c1-34(26,31)15-18-3-2-4-20(13-18)29-24-28-16-27-23(30-24)21-6-5-19(25)14-22(21)33-12-9-17-7-10-32-11-8-17/h2-6,13-14,16-17,26H,7-12,15H2,1H3,(H,27,28,29,30) YHLYDKKDZLWEJG-UHFFFAOYSA-N 168498 US9669034, 57 (rac)-4-{4-Fluoro-2-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 370 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168498&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618397 373987153 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476456 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(=N)(=O)C3CCOCC3)c2)n1 InChI=1S/C22H24FN5O3S/c1-30-20-12-16(23)5-6-19(20)21-25-14-26-22(28-21)27-17-4-2-3-15(11-17)13-32(24,29)18-7-9-31-10-8-18/h2-6,11-12,14,18,24H,7-10,13H2,1H3,(H,25,26,27,28) JINMVIWLGGPUOE-UHFFFAOYSA-N 168499 US9669034, 58 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-(3-{[S-(tetrahydro-2H-pyran-4-yl)sulfonimidoyl]methyl}phenyl)-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168499&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618398 373987154 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476458 COc1cc(F)ccc1-c1ncnc(Nc2ccc(Cl)c(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17ClFN5O2S/c1-27-16-8-12(20)3-5-14(16)17-22-10-23-18(25-17)24-13-4-6-15(19)11(7-13)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) ORWLRMMKZHWXOJ-UHFFFAOYSA-N 168500 US9669034, 59 (rac)-N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine::US9669034, 59.a N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer1::US9669034, 59.b N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168500&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618399 373987155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476460 COc1cc(F)ccc1-c1ncnc(Nc2ccc(Cl)c(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17ClFN5O2S/c1-27-16-8-12(20)3-5-14(16)17-22-10-23-18(25-17)24-13-4-6-15(19)11(7-13)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) ORWLRMMKZHWXOJ-UHFFFAOYSA-N 168500 US9669034, 59 (rac)-N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine::US9669034, 59.a N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer1::US9669034, 59.b N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168500&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618399 373987155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476462 COc1cc(F)ccc1-c1ncnc(Nc2ccc(Cl)c(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17ClFN5O2S/c1-27-16-8-12(20)3-5-14(16)17-22-10-23-18(25-17)24-13-4-6-15(19)11(7-13)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) ORWLRMMKZHWXOJ-UHFFFAOYSA-N 168500 US9669034, 59 (rac)-N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine::US9669034, 59.a N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer1::US9669034, 59.b N-{4-Chloro-3-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168500&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618399 373987155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476464 CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccccc2OCc2ccc(Cl)c(Cl)c2)c1 InChI=1S/C27H25Cl2N5O4S/c1-3-37-27(35)34-39(2,36)16-19-7-6-8-20(13-19)32-26-31-17-30-25(33-26)21-9-4-5-10-24(21)38-15-18-11-12-22(28)23(29)14-18/h4-14,17H,3,15-16H2,1-2H3,(H,30,31,32,33) OCAUNYSRASWZOP-UHFFFAOYSA-N 168514 US9669034, 60 (rac)-Ethyl[{3-[(4-{2-[(3,4-dichlorobenzyl)oxy]phenyl}-1,3,5-triazin-2-yl)amino]benzyl}(methyl)oxido-λ6-sulfanylidene]carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168514&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618400 373987156 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476466 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccccc2OCc2ccc(Cl)c(Cl)c2)c1 InChI=1S/C24H21Cl2N5O2S/c1-34(27,32)14-17-5-4-6-18(11-17)30-24-29-15-28-23(31-24)19-7-2-3-8-22(19)33-13-16-9-10-20(25)21(26)12-16/h2-12,15,27H,13-14H2,1H3,(H,28,29,30,31) YZYIXCCNLDPFSY-UHFFFAOYSA-N 168515 US9669034, 61 (rac)-4-{2-[(3,4-Dichlorobenzyl)oxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618401 373987157 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476468 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccccc2)c1 InChI=1S/C24H22FN5O2S/c1-33(26,31)15-18-8-5-9-20(12-18)29-24-28-16-27-23(30-24)21-11-10-19(25)13-22(21)32-14-17-6-3-2-4-7-17/h2-13,16,26H,14-15H2,1H3,(H,27,28,29,30) KEAPAIZOLSVRNZ-UHFFFAOYSA-N 168387 US9669034, 6 (rac)-4-[2-(Benzyloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 62 (rac)-4-(4-Fluoro-2-{[(2H5)phenyl(2H2)methyl]oxy}phenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168387&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618282 373987120 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476470 CC(Oc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1)C1CCCC1 InChI=1S/C24H28FN5O2S/c1-16(18-7-3-4-8-18)32-22-13-19(25)10-11-21(22)23-27-15-28-24(30-23)29-20-9-5-6-17(12-20)14-33(2,26)31/h5-6,9-13,15-16,18,26H,3-4,7-8,14H2,1-2H3,(H,27,28,29,30) UTZPONOYNCWWSY-UHFFFAOYSA-N 168532 US9669034, 63 4-[2-(1-cyclopentylethoxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine,mixtureofall4stereoisomers Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618402 373987158 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476471 COc1cc(F)ccc1-c1ncnc(Nc2cc(Cl)cc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H17ClFN5O2S/c1-27-16-8-13(20)3-4-15(16)17-22-10-23-18(25-17)24-14-6-11(5-12(19)7-14)9-28(2,21)26/h3-8,10,21H,9H2,1-2H3,(H,22,23,24,25) IWFLYGRDKJZMBD-UHFFFAOYSA-N 168533 US9669034, 64 (rac)-N-{3-Chloro-5-[(S-methylsulfonimidoyl)methyl]phenyl}-4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618462 373987159 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476473 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCCC(F)(F)F)c1 InChI=1S/C20H19F4N5O2S/c1-32(25,30)11-13-3-2-4-15(9-13)28-19-27-12-26-18(29-19)16-6-5-14(21)10-17(16)31-8-7-20(22,23)24/h2-6,9-10,12,25H,7-8,11H2,1H3,(H,26,27,28,29) RJBORTCWZVXGDR-UHFFFAOYSA-N 168541 US9669034, 65 (rac)-4-[4-Fluoro-2-(3,3,3-trifluoropropoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168541&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618463 373987160 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477300 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)ccn2)ncc1F InChI=1S/C19H17F2N3O3S/c1-27-17-8-13(20)3-4-14(17)15-9-19(23-10-16(15)21)24-18-7-12(5-6-22-18)11-28(2,25)26/h3-10H,11H2,1-2H3,(H,22,23,24) VRHHAMWTRSVIEX-UHFFFAOYSA-N 187120 US9670161, 1 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 8 US Patent 10.7270/Q29G5K05 aid1795028 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187120&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73508010 373987528 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477302 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)ccn2)ncc1F InChI=1S/C19H17F2N3O3S/c1-27-17-8-13(20)3-4-14(17)15-9-19(23-10-16(15)21)24-18-7-12(5-6-22-18)11-28(2,25)26/h3-10H,11H2,1-2H3,(H,22,23,24) VRHHAMWTRSVIEX-UHFFFAOYSA-N 187120 US9670161, 1 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 8 US Patent 10.7270/Q29G5K05 aid1795029 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187120&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73508010 373987528 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476475 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cccnc2)c1 InChI=1S/C23H21FN6O2S/c1-33(25,31)14-16-4-2-6-19(10-16)29-23-28-15-27-22(30-23)20-8-7-18(24)11-21(20)32-13-17-5-3-9-26-12-17/h2-12,15,25H,13-14H2,1H3,(H,27,28,29,30) PCURPHBYHAOEHD-UHFFFAOYSA-N 168572 US9669034, 66 (rac)-4-[4-Fluoro-2-(pyridin-3-ylmethoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618464 373987161 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476477 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccccn2)c1 InChI=1S/C23H21FN6O2S/c1-33(25,31)14-16-5-4-7-18(11-16)29-23-28-15-27-22(30-23)20-9-8-17(24)12-21(20)32-13-19-6-2-3-10-26-19/h2-12,15,25H,13-14H2,1H3,(H,27,28,29,30) DBAYHNCGOFKFSU-UHFFFAOYSA-N 168577 US9669034, 67 (rac)-4-[4-Fluoro-2-(pyridin-2-ylmethoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618465 373987162 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476479 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccncc2)c1 InChI=1S/C23H21FN6O2S/c1-33(25,31)14-17-3-2-4-19(11-17)29-23-28-15-27-22(30-23)20-6-5-18(24)12-21(20)32-13-16-7-9-26-10-8-16/h2-12,15,25H,13-14H2,1H3,(H,27,28,29,30) JSSJHBWAMPCAOA-UHFFFAOYSA-N 168580 US9669034, 68 (rac)-4-[4-Fluoro-2-(pyridin-4-ylmethoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618466 373987163 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476481 CC(Oc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1)c1ccc(F)cc1 InChI=1S/C25H23F2N5O2S/c1-16(18-6-8-19(26)9-7-18)34-23-13-20(27)10-11-22(23)24-29-15-30-25(32-24)31-21-5-3-4-17(12-21)14-35(2,28)33/h3-13,15-16,28H,14H2,1-2H3,(H,29,30,31,32) VNHDYKMEDVFEBK-UHFFFAOYSA-N 168589 US9669034, 69 4-{4-Fluoro-2-[1-(4-fluorophenyl)ethoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine,mixtureof4stereoisomers Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618467 373987164 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476483 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)cc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H16F2N6O2S/c1-29-17-8-13(20)3-4-16(17)18-23-11-24-19(27-18)26-15-6-12(5-14(21)7-15)9-30(2,28)25-10-22/h3-8,11H,9H2,1-2H3,(H,23,24,26,27) XUKWBMKTRVFRAS-UHFFFAOYSA-N 168591 US9669034, 70 (rac)-[(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide::US9669034, 71 [(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide;enantiomer1::US9669034, 72 [(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618524 373987165 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476485 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)cc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H16F2N6O2S/c1-29-17-8-13(20)3-4-16(17)18-23-11-24-19(27-18)26-15-6-12(5-14(21)7-15)9-30(2,28)25-10-22/h3-8,11H,9H2,1-2H3,(H,23,24,26,27) XUKWBMKTRVFRAS-UHFFFAOYSA-N 168591 US9669034, 70 (rac)-[(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide::US9669034, 71 [(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide;enantiomer1::US9669034, 72 [(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618524 373987165 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476487 COc1cc(F)ccc1-c1ncnc(Nc2cc(F)cc(CS(C)(=O)=NC#N)c2)n1 InChI=1S/C19H16F2N6O2S/c1-29-17-8-13(20)3-4-16(17)18-23-11-24-19(27-18)26-15-6-12(5-14(21)7-15)9-30(2,28)25-10-22/h3-8,11H,9H2,1-2H3,(H,23,24,26,27) XUKWBMKTRVFRAS-UHFFFAOYSA-N 168591 US9669034, 70 (rac)-[(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide::US9669034, 71 [(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide;enantiomer1::US9669034, 72 [(3-Fluoro-5-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl-λ6-sulfanylidene]cyanamide;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618524 373987165 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476489 CC#CCOc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C21H20FN5O2S/c1-3-4-10-29-19-12-16(22)8-9-18(19)20-24-14-25-21(27-20)26-17-7-5-6-15(11-17)13-30(2,23)28/h5-9,11-12,14,23H,10,13H2,1-2H3,(H,24,25,26,27) GPGQUICOSOWSJF-UHFFFAOYSA-N 169242 US9669034, 73 (rac)-4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 74 4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 75 4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169242&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618525 373987166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476491 CC#CCOc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C21H20FN5O2S/c1-3-4-10-29-19-12-16(22)8-9-18(19)20-24-14-25-21(27-20)26-17-7-5-6-15(11-17)13-30(2,23)28/h5-9,11-12,14,23H,10,13H2,1-2H3,(H,24,25,26,27) GPGQUICOSOWSJF-UHFFFAOYSA-N 169242 US9669034, 73 (rac)-4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 74 4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 75 4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169242&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618525 373987166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476493 CC#CCOc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C21H20FN5O2S/c1-3-4-10-29-19-12-16(22)8-9-18(19)20-24-14-25-21(27-20)26-17-7-5-6-15(11-17)13-30(2,23)28/h5-9,11-12,14,23H,10,13H2,1-2H3,(H,24,25,26,27) GPGQUICOSOWSJF-UHFFFAOYSA-N 169242 US9669034, 73 (rac)-4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 74 4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 75 4-[2-(But-2-yn-1-yloxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169242&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618525 373987166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476495 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCCC2CC2)c1 InChI=1S/C22H24FN5O2S/c1-31(24,29)13-16-3-2-4-18(11-16)27-22-26-14-25-21(28-22)19-8-7-17(23)12-20(19)30-10-9-15-5-6-15/h2-4,7-8,11-12,14-15,24H,5-6,9-10,13H2,1H3,(H,25,26,27,28) UQLQRSRVCDLTRN-UHFFFAOYSA-N 169372 US9669034, 76 (rac)-4-[2-(2-Cyclopropylethoxy)-4-fluorophenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169372&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89239803 373987167 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476497 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC#C)c1 InChI=1S/C20H18FN5O2S/c1-3-9-28-18-11-15(21)7-8-17(18)19-23-13-24-20(26-19)25-16-6-4-5-14(10-16)12-29(2,22)27/h1,4-8,10-11,13,22H,9,12H2,2H3,(H,23,24,25,26) VNQSADCYOBYZMX-UHFFFAOYSA-N 169470 US9669034, 77 (rac)-4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 78 4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 79 4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618528 373987168 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476499 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC#C)c1 InChI=1S/C20H18FN5O2S/c1-3-9-28-18-11-15(21)7-8-17(18)19-23-13-24-20(26-19)25-16-6-4-5-14(10-16)12-29(2,22)27/h1,4-8,10-11,13,22H,9,12H2,2H3,(H,23,24,25,26) VNQSADCYOBYZMX-UHFFFAOYSA-N 169470 US9669034, 77 (rac)-4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 78 4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 79 4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618528 373987168 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476501 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCC#C)c1 InChI=1S/C20H18FN5O2S/c1-3-9-28-18-11-15(21)7-8-17(18)19-23-13-24-20(26-19)25-16-6-4-5-14(10-16)12-29(2,22)27/h1,4-8,10-11,13,22H,9,12H2,2H3,(H,23,24,25,26) VNQSADCYOBYZMX-UHFFFAOYSA-N 169470 US9669034, 77 (rac)-4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine::US9669034, 78 4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 79 4-[4-Fluoro-2-(prop-2-yn-1-yloxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618528 373987168 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476503 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccc(F)c(F)c2)c1 InChI=1S/C24H20F3N5O2S/c1-35(28,33)13-16-3-2-4-18(9-16)31-24-30-14-29-23(32-24)19-7-6-17(25)11-22(19)34-12-15-5-8-20(26)21(27)10-15/h2-11,14,28H,12-13H2,1H3,(H,29,30,31,32) MKNZVUBVDJOQSY-UHFFFAOYSA-N 169543 US9669034, 80 (rac)-4-{2-[(3,4-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618529 373987169 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476505 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2cncs2)c1 InChI=1S/C21H19FN6O2S2/c1-32(23,29)11-14-3-2-4-16(7-14)27-21-26-12-25-20(28-21)18-6-5-15(22)8-19(18)30-10-17-9-24-13-31-17/h2-9,12-13,23H,10-11H2,1H3,(H,25,26,27,28) PBWKVTQEEJYCRC-UHFFFAOYSA-N 169742 US9669034, 81 (rac)-4-[4-Fluoro-2-(1,3-thiazol-5-ylmethoxy)phenyl]-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=169742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=169742&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618587 373987170 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476507 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccnc(F)c2)c1 InChI=1S/C23H20F2N6O2S/c1-34(26,32)13-16-3-2-4-18(9-16)30-23-29-14-28-22(31-23)19-6-5-17(24)11-20(19)33-12-15-7-8-27-21(25)10-15/h2-11,14,26H,12-13H2,1H3,(H,28,29,30,31) RQFBVVFCXVOINX-UHFFFAOYSA-N 170016 US9669034, 82 (rac)-4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazm-2-amine::US9669034, 83 4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 84 4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170016&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618586 373987171 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 476509 CS(=N)(=O)Cc1cccc(Nc2ncnc(n2)-c2ccc(F)cc2OCc2ccnc(F)c2)c1 InChI=1S/C23H20F2N6O2S/c1-34(26,32)13-16-3-2-4-18(9-16)30-23-29-14-28-22(31-23)19-6-5-17(24)11-20(19)33-12-15-7-8-27-21(25)10-15/h2-11,14,26H,12-13H2,1H3,(H,28,29,30,31) RQFBVVFCXVOINX-UHFFFAOYSA-N 170016 US9669034, 82 (rac)-4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazm-2-amine::US9669034, 83 4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer1::US9669034, 84 4-{4-Fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine;enantiomer2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 8 22.00 C US Patent 10.7270/Q22Z13PG aid1795018 US9669034 Lucking, U; Bohlmann, R; Scholz, A; Siemeister, G; Gnoth, MJ; Bomer, U; Kosemund, D; Lienau, P; Ruhter, G; Schultz-Fademrecht, C Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=170016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=170016&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618586 373987171 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477304 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(C)n2)ncc1F InChI=1S/C20H19F2N3O3S/c1-12-6-13(11-29(3,26)27)7-20(24-12)25-19-9-16(17(22)10-23-19)15-5-4-14(21)8-18(15)28-2/h4-10H,11H2,1-3H3,(H,23,24,25) NHGVXOXQUNLGNK-UHFFFAOYSA-N 187121 US9670161, 2 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 8 US Patent 10.7270/Q29G5K05 aid1795028 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187121&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775781 373987529 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477306 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(C)n2)ncc1F InChI=1S/C20H19F2N3O3S/c1-12-6-13(11-29(3,26)27)7-20(24-12)25-19-9-16(17(22)10-23-19)15-5-4-14(21)8-18(15)28-2/h4-10H,11H2,1-3H3,(H,23,24,25) NHGVXOXQUNLGNK-UHFFFAOYSA-N 187121 US9670161, 2 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 8 US Patent 10.7270/Q29G5K05 aid1795029 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187121&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775781 373987529 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477308 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(F)n2)ncc1F InChI=1S/C19H16F3N3O3S/c1-28-16-7-12(20)3-4-13(16)14-8-18(23-9-15(14)21)25-19-6-11(5-17(22)24-19)10-29(2,26)27/h3-9H,10H2,1-2H3,(H,23,24,25) WRWJZWZZZNJJJE-UHFFFAOYSA-N 187122 US9670161, 3 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-fIuoro-4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 8 US Patent 10.7270/Q29G5K05 aid1795028 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187122&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775662 373987530 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477310 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(F)n2)ncc1F InChI=1S/C19H16F3N3O3S/c1-28-16-7-12(20)3-4-13(16)14-8-18(23-9-15(14)21)25-19-6-11(5-17(22)24-19)10-29(2,26)27/h3-9H,10H2,1-2H3,(H,23,24,25) WRWJZWZZZNJJJE-UHFFFAOYSA-N 187122 US9670161, 3 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-fIuoro-4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 8 US Patent 10.7270/Q29G5K05 aid1795029 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187122&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775662 373987530 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477312 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(n2)C(F)(F)F)ncc1F InChI=1S/C20H16F5N3O3S/c1-31-16-7-12(21)3-4-13(16)14-8-18(26-9-15(14)22)28-19-6-11(10-32(2,29)30)5-17(27-19)20(23,24)25/h3-9H,10H2,1-2H3,(H,26,27,28) MPGNJCQEZSESLQ-UHFFFAOYSA-N 187123 US9670161, 4 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]-6-(trifluoromethyl)pyridin-2-yl}pyridine-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4 8 US Patent 10.7270/Q29G5K05 aid1795028 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187123&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775782 373987531 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477314 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(n2)C(F)(F)F)ncc1F InChI=1S/C20H16F5N3O3S/c1-31-16-7-12(21)3-4-13(16)14-8-18(26-9-15(14)22)28-19-6-11(10-32(2,29)30)5-17(27-19)20(23,24)25/h3-9H,10H2,1-2H3,(H,26,27,28) MPGNJCQEZSESLQ-UHFFFAOYSA-N 187123 US9670161, 4 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]-6-(trifluoromethyl)pyridin-2-yl}pyridine-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3 8 US Patent 10.7270/Q29G5K05 aid1795029 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187123&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775782 373987531 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477316 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(n2)C(F)F)ncc1F InChI=1S/C20H17F4N3O3S/c1-30-17-7-12(21)3-4-13(17)14-8-18(25-9-15(14)22)27-19-6-11(10-31(2,28)29)5-16(26-19)20(23)24/h3-9,20H,10H2,1-2H3,(H,25,26,27) DXLAOXPSVTUHAP-UHFFFAOYSA-N 187124 US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfonyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2 8 US Patent 10.7270/Q29G5K05 aid1795028 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187124&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775783 373987532 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 477318 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(n2)C(F)F)ncc1F InChI=1S/C20H17F4N3O3S/c1-30-17-7-12(21)3-4-13(17)14-8-18(25-9-15(14)22)27-19-6-11(10-31(2,28)29)5-16(26-19)20(23)24/h3-9,20H,10H2,1-2H3,(H,25,26,27) DXLAOXPSVTUHAP-UHFFFAOYSA-N 187124 US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfonyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1 8 US Patent 10.7270/Q29G5K05 aid1795029 US9670161 Lucking, U; Bohnke, N; Scholz, A; Lienau, P; Siemeister, G; Bomer, U; Kosemund, D; Bohlmann, R; Zorn, L Bayer Pharma Aktiengesellschaft http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=187124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=187124&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73775783 373987532 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51027075 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 ChEMBL 10.1016/j.ejmech.2012.08.033 10.7270/Q2ST7R34 22982525 Bettayeb, K; Gresh, N; Meijer, L; Oumata, N TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51027076 CC(C)n1cnc2c(NCc3ccc(cc3)-c3ccccn3)nc(NC[C@@H](O)CO)nc12 InChI=1S/C23H27N7O2/c1-15(2)30-14-27-20-21(28-23(29-22(20)30)26-12-18(32)13-31)25-11-16-6-8-17(9-7-16)19-5-3-4-10-24-19/h3-10,14-15,18,31-32H,11-13H2,1-2H3,(H2,25,26,28,29)/t18-/m1/s1 BIUDJFOTQAVFMN-GOSISDBHSA-N 50420297 CHEMBL2089032 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 ChEMBL 10.1016/j.ejmech.2012.08.033 10.7270/Q2ST7R34 22982525 Bettayeb, K; Gresh, N; Meijer, L; Oumata, N TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420297&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46912953 163369321 CHEMBL2089032 ZINC84739058 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51027077 CC(C)n1cnc2c(NCc3ccc(cc3)-c3ccccn3)nc(N[C@@H]3CCC[C@H](O)[C@@H]3O)nc12 InChI=1S/C26H31N7O2/c1-16(2)33-15-29-22-24(28-14-17-9-11-18(12-10-17)19-6-3-4-13-27-19)31-26(32-25(22)33)30-20-7-5-8-21(34)23(20)35/h3-4,6,9-13,15-16,20-21,23,34-35H,5,7-8,14H2,1-2H3,(H2,28,30,31,32)/t20-,21+,23-/m1/s1 UVOREYMEAFPJPX-FUPPJEDESA-N 50420298 CHEMBL2089033 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 370 ChEMBL 10.1016/j.ejmech.2012.08.033 10.7270/Q2ST7R34 22982525 Bettayeb, K; Gresh, N; Meijer, L; Oumata, N TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420298&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46912952 163369322 CHEMBL2089033 ZINC84739060 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51027078 CC(C)n1cnc2c(NCc3ccc(cc3)-c3ccccn3)nc(nc12)N1C[C@H](O)C[C@H]1CO InChI=1S/C25H29N7O2/c1-16(2)32-15-28-22-23(29-25(30-24(22)32)31-13-20(34)11-19(31)14-33)27-12-17-6-8-18(9-7-17)21-5-3-4-10-26-21/h3-10,15-16,19-20,33-34H,11-14H2,1-2H3,(H,27,29,30)/t19-,20+/m0/s1 OQUWTJLQOZIRFA-VQTJNVASSA-N 50420299 CHEMBL2089034 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 ChEMBL 10.1016/j.ejmech.2012.08.033 10.7270/Q2ST7R34 22982525 Bettayeb, K; Gresh, N; Meijer, L; Oumata, N TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70695463 163369323 CHEMBL2089034 ZINC84739063 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51027079 CC(C)n1cnc2c(NCc3ccc(cc3)-c3ccccn3)nc(NCC[C@H](O)CO)nc12 InChI=1S/C24H29N7O2/c1-16(2)31-15-28-21-22(29-24(30-23(21)31)26-12-10-19(33)14-32)27-13-17-6-8-18(9-7-17)20-5-3-4-11-25-20/h3-9,11,15-16,19,32-33H,10,12-14H2,1-2H3,(H2,26,27,29,30)/t19-/m0/s1 RURHVWQWTJYUPS-IBGZPJMESA-N 50420300 CHEMBL2089035 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1010 ChEMBL 10.1016/j.ejmech.2012.08.033 10.7270/Q2ST7R34 22982525 Bettayeb, K; Gresh, N; Meijer, L; Oumata, N TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420300&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 70684923 163369324 CHEMBL2089035 ZINC84742537 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51027080 CC(C)[C@H](N)C(=O)OC[C@H](O)CNc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C28H36N8O3/c1-17(2)23(29)27(38)39-15-21(37)14-32-28-34-25(24-26(35-28)36(16-33-24)18(3)4)31-13-19-8-10-20(11-9-19)22-7-5-6-12-30-22/h5-12,16-18,21,23,37H,13-15,29H2,1-4H3,(H2,31,32,34,35)/t21-,23+/m1/s1 OOYQNTZOMNZRSG-GGAORHGYSA-N 50420301 CHEMBL2089036 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 ChEMBL 10.1016/j.ejmech.2012.08.033 10.7270/Q2ST7R34 22982525 Bettayeb, K; Gresh, N; Meijer, L; Oumata, N TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420301&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46912955 163369325 CHEMBL2089036 C03317 ZINC84730397 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51070412 NC1CCC(CC1)Nc1nc(NCc2ccc(nc2)-c2ccccc2O)c2ncn(C3CCCC3)c2n1 InChI=1S/C28H34N8O/c29-19-10-12-20(13-11-19)33-28-34-26(25-27(35-28)36(17-32-25)21-5-1-2-6-21)31-16-18-9-14-23(30-15-18)22-7-3-4-8-24(22)37/h3-4,7-9,14-15,17,19-21,37H,1-2,5-6,10-13,16,29H2,(H2,31,33,34,35) UVKLAINVJNUJNX-UHFFFAOYSA-N 50437236 CHEMBL2402946 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/jm4006884 10.7270/Q2FX7BVZ 23829517 Gucky, T; Jorda, R; Zatloukal, M; Bazgier, V; Berka, K; Reznickova, E; Beres, T; Strnad, M; Krystof, V Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437236&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71664364 175449553 CHEMBL2402946 ZINC96273135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50546638 CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12 InChI=1S/C23H22N4O2/c1-23(2)17-13-24-22(25-14-7-4-3-5-8-14)26-20(17)27(21(23)29)18-12-11-16-15(18)9-6-10-19(16)28/h3-10,13,18,28H,11-12H2,1-2H3,(H,24,25,26)/t18-/m0/s1 XLFNLJYGUOLEJS-SFHVURJKSA-N 50208911 CHEMBL3884319 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1582 ChEMBL 10.1016/j.bmcl.2016.08.068 10.7270/Q2N018JC 27816515 Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208911&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 69036886 375982220 CHEMBL3884319 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785554 C(Cc1ccccc1)Nc1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C19H17N5/c1-2-5-14(6-3-1)8-11-21-19-22-12-9-17(24-19)16-13-23-18-15(16)7-4-10-20-18/h1-7,9-10,12-13H,8,11H2,(H,20,23)(H,21,22,24) HLJHKVNZSXUMIL-UHFFFAOYSA-N 50250828 CHEMBL4098661 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250828&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137658772 401962441 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50713830 CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(\C=C\c3ccccc3)o2)c1 InChI=1S/C20H20N2O4S/c1-3-27(23,24)17-11-12-19(25-2)18(13-17)22-20-21-14-16(26-20)10-9-15-7-5-4-6-8-15/h4-14H,3H2,1-2H3,(H,21,22)/b10-9+ YIEXHVPVWYOPCC-MDZDMXLPSA-N 50234810 CHEMBL4065167 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 ChEMBL 10.1016/j.ejmech.2016.11.003 10.7270/Q2S75JJV 27940419 Murár, M; Dobiaš, J; Šramel, P; Addová, G; Hanquet, G; Bohác, A Comenius University in Bratislava http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234810&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137631839 384584865 CHEMBL4065167 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724404 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1 InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24) OWXORKPNCHJYOF-UHFFFAOYSA-N 50235342 CHEMBL319467::NU-6102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1070 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235342&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 4SP 5M57,6BSS,2C6O,4EOK,4EOR,1H1S,5LQF,2IW8,2IW9 4566 384991216 CHEMBL319467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724405 NS(=O)(=O)c1ccc(Nc2ncc3nc[nH]c3n2)cc1 InChI=1S/C11H10N6O2S/c12-20(18,19)8-3-1-7(2-4-8)16-11-13-5-9-10(17-11)15-6-14-9/h1-6H,(H2,12,18,19)(H2,13,14,15,16,17) ZVHABBMEQZWREZ-UHFFFAOYSA-N 50235339 CHEMBL4073211 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38000 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235339&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137640533 384991213 CHEMBL4073211 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724410 CCC(C)Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc2[nH]cnc12 InChI=1S/C15H18N6O3S/c1-3-9(2)24-14-12-13(18-8-17-12)20-15(21-14)19-10-4-6-11(7-5-10)25(16,22)23/h4-9H,3H2,1-2H3,(H2,16,22,23)(H2,17,18,19,20,21) LSJIMMQWBYSNTG-UHFFFAOYSA-N 50235343 CHEMBL4103249 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 570 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235343&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137658097 384991217 CHEMBL4103249 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724412 NS(=O)(=O)c1ccc(Nc2nc(-c3ccccc3)c3nc[nH]c3n2)cc1 InChI=1S/C17H14N6O2S/c18-26(24,25)13-8-6-12(7-9-13)21-17-22-14(11-4-2-1-3-5-11)15-16(23-17)20-10-19-15/h1-10H,(H2,18,24,25)(H2,19,20,21,22,23) GETVVUWUPLHXBE-UHFFFAOYSA-N 50235345 CHEMBL4105278 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 570 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235345&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137656537 384991219 CHEMBL4105278 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724413 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nn[nH]c3n2)cc1 InChI=1S/C17H21N7O3S/c18-28(25,26)13-8-6-12(7-9-13)19-17-20-15-14(22-24-23-15)16(21-17)27-10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H2,18,25,26)(H2,19,20,21,22,23,24) HQGOXGMCHYWWCV-UHFFFAOYSA-N 50235335 CHEMBL4092981 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 750 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235335&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137654694 384991209 CHEMBL4092981 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724414 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3cn[nH]c3n2)cc1 InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)21-18-22-16-15(10-20-24-16)17(23-18)27-11-12-4-2-1-3-5-12/h6-10,12H,1-5,11H2,(H2,19,25,26)(H2,20,21,22,23,24) MWINFFOPTSOXJI-UHFFFAOYSA-N 50235336 CHEMBL4085238 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4600 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235336&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24800068 384991210 CHEMBL4085238 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724415 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3cc[nH]c3n2)cc1 InChI=1S/C19H23N5O3S/c20-28(25,26)15-8-6-14(7-9-15)22-19-23-17-16(10-11-21-17)18(24-19)27-12-13-4-2-1-3-5-13/h6-11,13H,1-5,12H2,(H2,20,25,26)(H2,21,22,23,24) NJZMZGLYZQNCHS-UHFFFAOYSA-N 50235337 CHEMBL4062554 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235337&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137634367 384991211 CHEMBL4062554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50724416 NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3nc[nH]c3n2)cc1 InChI=1S/C23H18N6O2S/c24-32(30,31)19-11-9-18(10-12-19)27-23-28-20(21-22(29-23)26-14-25-21)17-8-4-7-16(13-17)15-5-2-1-3-6-15/h1-14H,(H2,24,30,31)(H2,25,26,27,28,29) FUGRWXRQJGJIER-UHFFFAOYSA-N 50235334 CHEMBL4070391 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25000 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 123132899 384991208 CHEMBL4070391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50765594 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 197 ChEMBL 10.1021/acs.jmedchem.8b00209 10.7270/Q2KS6TZK 29518312 Li, Y; Luo, X; Guo, Q; Nie, Y; Wang, T; Zhang, C; Huang, Z; Wang, X; Liu, Y; Chen, Y; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696622 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)cc(F)c1 InChI=1S/C19H17F2N3O2S/c1-27(25,26)24-6-3-12(4-7-24)18-11-17-16(2-5-22-19(17)23-18)13-8-14(20)10-15(21)9-13/h2-3,5,8-11H,4,6-7H2,1H3,(H,22,23) UZVRVELSXFZNFS-UHFFFAOYSA-N 353254 4-(3,5-difluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 486 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353254&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421216 386046993 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696623 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(Cl)cc1Cl InChI=1S/C19H17Cl2N3O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-16-14(4-7-22-19(16)23-18)15-3-2-13(20)10-17(15)21/h2-5,7,10-11H,6,8-9H2,1H3,(H,22,23) AFXZSUJGKYDXQD-UHFFFAOYSA-N 353255 4-(2,4-dichlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 487 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 720 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353255&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419662 386046994 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696624 CCc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H23N3O2S/c1-3-15-6-4-5-7-17(15)18-8-11-22-21-19(18)14-20(23-21)16-9-12-24(13-10-16)27(2,25)26/h4-9,11,14H,3,10,12-13H2,1-2H3,(H,22,23) NMIKDULGLZEUQR-UHFFFAOYSA-N 353256 4-(2-ethylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 488 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353256&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420234 386046995 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696625 Cc1ccc(c(C)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H23N3O2S/c1-14-4-5-17(15(2)12-14)18-6-9-22-21-19(18)13-20(23-21)16-7-10-24(11-8-16)27(3,25)26/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,22,23) UUONONOXTPCJTL-UHFFFAOYSA-N 353257 4-(2,4-dimethylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 489 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353257&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420392 386046996 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696626 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(Cl)ccc1Cl InChI=1S/C19H17Cl2N3O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-16-14(4-7-22-19(16)23-18)15-10-13(20)2-3-17(15)21/h2-5,7,10-11H,6,8-9H2,1H3,(H,22,23) RSVMMWJYPYWKNV-UHFFFAOYSA-N 353258 4-(2,5-dichlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 490 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 640 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353258&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419921 386046997 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696627 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C19H17Cl2N3O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-15-14(4-7-22-19(15)23-18)13-2-3-16(20)17(21)10-13/h2-5,7,10-11H,6,8-9H2,1H3,(H,22,23) XWVVRDKCJGWYTQ-UHFFFAOYSA-N 353259 4-(3,4-dichlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 491 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353259&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421028 386046998 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696628 CS(=O)(=O)Nc1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H22N4O4S2/c1-29(25,26)23-16-5-3-14(4-6-16)17-7-10-21-20-18(17)13-19(22-20)15-8-11-24(12-9-15)30(2,27)28/h3-8,10,13,23H,9,11-12H2,1-2H3,(H,21,22) VTKOUZBOVLOXPN-UHFFFAOYSA-N 353260 N-(4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)methanesulfonamide::US9796708, Example 492 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353260&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420753 386046999 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696629 COc1ccc(Cl)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20ClN3O3S/c1-27-19-4-3-14(21)11-16(19)15-5-8-22-20-17(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) BLUJKYWYTXBKNS-UHFFFAOYSA-N 353261 4-(5-chloro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 493 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353261&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420685 386047000 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696630 COc1ccc(cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O)C(C)C InChI=1S/C23H27N3O3S/c1-15(2)17-5-6-22(29-3)19(13-17)18-7-10-24-23-20(18)14-21(25-23)16-8-11-26(12-9-16)30(4,27)28/h5-8,10,13-15H,9,11-12H2,1-4H3,(H,24,25) SVDCFMGULOKFSX-UHFFFAOYSA-N 353262 4-[2-methoxy-5-(propan-2-yl)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 494 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353262&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420532 386047001 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696631 COc1ccc(C)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H23N3O3S/c1-14-4-5-20(27-2)17(12-14)16-6-9-22-21-18(16)13-19(23-21)15-7-10-24(11-8-15)28(3,25)26/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,22,23) LSAOFQWTWIYIBX-UHFFFAOYSA-N 353263 4-(2-methoxy-5-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 495 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353263&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420075 386047002 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696632 COc1ccc(cc1C)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H23N3O3S/c1-14-12-16(4-5-20(14)27-2)17-6-9-22-21-18(17)13-19(23-21)15-7-10-24(11-8-15)28(3,25)26/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,22,23) FCMHEJHBOJNTPC-UHFFFAOYSA-N 353264 4-(4-methoxy-3-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 496 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420662 386047003 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696633 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1C#N InChI=1S/C20H18N4O2S/c1-27(25,26)24-10-7-14(8-11-24)19-12-18-17(6-9-22-20(18)23-19)16-5-3-2-4-15(16)13-21/h2-7,9,12H,8,10-11H2,1H3,(H,22,23) IENBJMANLYOVEK-UHFFFAOYSA-N 353265 2-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzonitrile::US9796708, Example 497 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 830 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353265&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420184 386047004 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696634 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H21N3O3S/c1-26-19-6-4-3-5-16(19)15-7-10-21-20-17(15)13-18(22-20)14-8-11-23(12-9-14)27(2,24)25/h3-8,10,13H,9,11-12H2,1-2H3,(H,21,22) PRUIIHIGKGXQGL-UHFFFAOYSA-N 353266 4-(2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 498 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353266&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420382 386047005 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696635 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(c1)C#N InChI=1S/C20H18N4O2S/c1-27(25,26)24-9-6-15(7-10-24)19-12-18-17(5-8-22-20(18)23-19)16-4-2-3-14(11-16)13-21/h2-6,8,11-12H,7,9-10H2,1H3,(H,22,23) QECDQHYNIFTPBE-UHFFFAOYSA-N 353267 3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzonitrile::US9796708, Example 499 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 670 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353267&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420788 386047006 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696636 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1C(F)(F)F InChI=1S/C20H18F3N3O2S/c1-29(27,28)26-10-7-13(8-11-26)18-12-16-14(6-9-24-19(16)25-18)15-4-2-3-5-17(15)20(21,22)23/h2-7,9,12H,8,10-11H2,1H3,(H,24,25) HMESMVZBICDSQQ-UHFFFAOYSA-N 353268 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-[2-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin::US9796708, Example 500 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353268&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421280 386047007 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696637 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(Cl)c1 InChI=1S/C19H18ClN3O2S/c1-26(24,25)23-9-6-13(7-10-23)18-12-17-16(5-8-21-19(17)22-18)14-3-2-4-15(20)11-14/h2-6,8,11-12H,7,9-10H2,1H3,(H,21,22) NCEIGWXCOFFOHJ-UHFFFAOYSA-N 353269 4-(3-chlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 501 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 690 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353269&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420022 386047008 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696638 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1Cl InChI=1S/C19H18ClN3O2S/c1-26(24,25)23-10-7-13(8-11-23)18-12-16-14(6-9-21-19(16)22-18)15-4-2-3-5-17(15)20/h2-7,9,12H,8,10-11H2,1H3,(H,21,22) ZROZFYKZBGQQMU-UHFFFAOYSA-N 353270 4-(2-chlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 502 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353270&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421195 386047009 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696639 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(ccc1F)C(F)(F)F InChI=1S/C20H17F4N3O2S/c1-30(28,29)27-8-5-12(6-9-27)18-11-16-14(4-7-25-19(16)26-18)15-10-13(20(22,23)24)2-3-17(15)21/h2-5,7,10-11H,6,8-9H2,1H3,(H,25,26) QTEWJJCGBZGNEY-UHFFFAOYSA-N 353271 4-[2-fluoro-5-(trifluoromethyl)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 503 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4700 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353271&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419832 386047010 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696640 COc1ccc(cc1Cl)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20ClN3O3S/c1-27-19-4-3-14(11-17(19)21)15-5-8-22-20-16(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) VZPPUOMLIHCMLO-UHFFFAOYSA-N 353272 4-(3-chloro-4-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 504 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353272&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420379 386047011 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696641 Cc1ccc(F)c(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O2S/c1-13-3-4-18(21)16(11-13)15-5-8-22-20-17(15)12-19(23-20)14-6-9-24(10-7-14)27(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) OUCAETXTVQRIEG-UHFFFAOYSA-N 353273 4-(2-fluoro-5-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 505 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353273&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420543 386047012 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696642 Cc1cc(Cl)cc(c1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H19ClFN3O2S/c1-12-9-14(21)10-16(19(12)22)15-3-6-23-20-17(15)11-18(24-20)13-4-7-25(8-5-13)28(2,26)27/h3-4,6,9-11H,5,7-8H2,1-2H3,(H,23,24) DVVCDEOMZZAMLG-UHFFFAOYSA-N 353274 4-(5-chloro-2-fluoro-3-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 506 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353274&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420904 386047013 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696643 CCCOc1ccc(Cl)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24ClN3O3S/c1-3-12-29-21-5-4-16(23)13-18(21)17-6-9-24-22-19(17)14-20(25-22)15-7-10-26(11-8-15)30(2,27)28/h4-7,9,13-14H,3,8,10-12H2,1-2H3,(H,24,25) CJTAIHRUKHICBF-UHFFFAOYSA-N 353275 4-(5-chloro-2-propoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 507 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353275&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420240 386047014 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696644 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F InChI=1S/C27H24F3N5O/c1-31-27(36)35-8-5-17(6-9-35)25-14-23-21(4-7-32-26(23)34-25)22-13-20(2-3-24(22)30)33-15-16-10-18(28)12-19(29)11-16/h2-5,7,10-14,33H,6,8-9,15H2,1H3,(H,31,36)(H,32,34) QTZYTLSJESSMFY-UHFFFAOYSA-N 353276 4-(4-{5-[(3,5-difluorobenzyl)amino]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 508 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353276&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419728 386047015 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696645 OCC(O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F 353277 3-[4-(4-{5-[(3,5-difluorobenzyl)amino]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl]propane-1,2-diol::US9796708, Example 509 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353277&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420554 386047016 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696646 CCOC(=O)C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1O 353278 US9796708, Example 510::ethyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 470 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353278&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208108 386047017 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696647 CCOc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-3-28-20-5-4-15(22)12-17(20)16-6-9-23-21-18(16)13-19(24-21)14-7-10-25(11-8-14)29(2,26)27/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,23,24) YUJHWZGDZUIIKX-UHFFFAOYSA-N 353279 4-(2-ethoxy-5-fluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 511 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353279&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420217 386047018 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696648 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(Cl)c1Cl InChI=1S/C19H17Cl2N3O2S/c1-27(25,26)24-9-6-12(7-10-24)17-11-15-13(5-8-22-19(15)23-17)14-3-2-4-16(20)18(14)21/h2-6,8,11H,7,9-10H2,1H3,(H,22,23) YJBRMOKLZXYKRN-UHFFFAOYSA-N 353280 4-(2,3-dichlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 512 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353280&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420657 386047019 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696649 Cc1ccc(cc1Cl)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20ClN3O2S/c1-13-3-4-15(11-18(13)21)16-5-8-22-20-17(16)12-19(23-20)14-6-9-24(10-7-14)27(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) BVGNLCQYKUNXAJ-UHFFFAOYSA-N 353281 4-(3-chloro-4-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 513 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419917 386047020 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696650 Cc1ccc(cc1N)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H22N4O2S/c1-13-3-4-15(11-18(13)21)16-5-8-22-20-17(16)12-19(23-20)14-6-9-24(10-7-14)27(2,25)26/h3-6,8,11-12H,7,9-10,21H2,1-2H3,(H,22,23) PUYMPOWSHHCCPE-UHFFFAOYSA-N 353282 2-methyl-5-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 514 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353282&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897314 386047021 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696651 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C25H22FN3O2S/c1-32(30,31)29-13-10-18(11-14-29)24-16-22-20(9-12-27-25(22)28-24)19-7-8-21(23(26)15-19)17-5-3-2-4-6-17/h2-10,12,15-16H,11,13-14H2,1H3,(H,27,28) HNJNFVUCRLWNTH-UHFFFAOYSA-N 353283 4-(2-fluorobiphenyl-4-yl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 515 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353283&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421213 386047022 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696652 CC(C)Oc1cccc(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H25N3O3S/c1-15(2)28-18-6-4-5-17(13-18)19-7-10-23-22-20(19)14-21(24-22)16-8-11-25(12-9-16)29(3,26)27/h4-8,10,13-15H,9,11-12H2,1-3H3,(H,23,24) LZWYRWRTAFQMBU-UHFFFAOYSA-N 353284 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-[3-(propan-2-yloxy)phenyl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 516 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 440 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353284&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419838 386047023 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696653 CCCOc1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-3-12-29-21-5-4-16(13-19(21)23)17-6-9-24-22-18(17)14-20(25-22)15-7-10-26(11-8-15)30(2,27)28/h4-7,9,13-14H,3,8,10-12H2,1-2H3,(H,24,25) GDCHFJVOPUYQOO-UHFFFAOYSA-N 353285 4-(3-fluoro-4-propoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 517 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353285&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420316 386047024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696654 CC(C)Oc1ccc(F)c(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-14(2)29-16-4-5-20(23)18(12-16)17-6-9-24-22-19(17)13-21(25-22)15-7-10-26(11-8-15)30(3,27)28/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,24,25) LVXRBQJSQOSVMX-UHFFFAOYSA-N 353286 4-[2-fluoro-5-(propan-2-yloxy)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 518 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 760 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353286&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420918 386047025 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696655 CCCCOc1ccc(cc1Cl)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H26ClN3O3S/c1-3-4-13-30-22-6-5-17(14-20(22)24)18-7-10-25-23-19(18)15-21(26-23)16-8-11-27(12-9-16)31(2,28)29/h5-8,10,14-15H,3-4,9,11-13H2,1-2H3,(H,25,26) VWEBFSLSEIJWQT-UHFFFAOYSA-N 353287 4-(4-butoxy-3-chlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353287&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419667 386047026 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696656 CC(C)COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H27N3O3S/c1-16(2)15-29-22-7-5-4-6-19(22)18-8-11-24-23-20(18)14-21(25-23)17-9-12-26(13-10-17)30(3,27)28/h4-9,11,14,16H,10,12-13,15H2,1-3H3,(H,24,25) WUVDBKJHIXKEIV-UHFFFAOYSA-N 353288 4-[2-(2-methylpropoxy)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 520 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353288&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420110 386047027 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696657 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(cc1)C#N InChI=1S/C20H18N4O2S/c1-27(25,26)24-10-7-16(8-11-24)19-12-18-17(6-9-22-20(18)23-19)15-4-2-14(13-21)3-5-15/h2-7,9,12H,8,10-11H2,1H3,(H,22,23) XPWBLJYBKHGSHO-UHFFFAOYSA-N 353289 4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzonitrile::US9796708, Example 521 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353289&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420157 386047028 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696658 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1 InChI=1S/C19H19N3O2S/c1-25(23,24)22-11-8-15(9-12-22)18-13-17-16(7-10-20-19(17)21-18)14-5-3-2-4-6-14/h2-8,10,13H,9,11-12H2,1H3,(H,20,21) LVIFMQZIYFPOCA-UHFFFAOYSA-N 353290 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-phenyl-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 522 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353290&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420595 386047029 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696659 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCN(CC(O)=O)CC1 InChI=1S/C26H29FN4O3/c1-34-24-3-2-18(27)14-21(24)20-4-9-28-26-22(20)15-23(29-26)17-5-12-31(13-6-17)19-7-10-30(11-8-19)16-25(32)33/h2-5,9,14-15,19H,6-8,10-13,16H2,1H3,(H,28,29)(H,32,33) IPEXWMRLQXTKEW-UHFFFAOYSA-N 353291 (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}piperidin-1-yl)acetic acid::US9796708, Example 523 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353291&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419953 386047030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696660 COc1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O3S/c1-27-19-4-3-14(11-17(19)21)15-5-8-22-20-16(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) WCQOIHZRPYSWEH-UHFFFAOYSA-N 353292 4-(3-fluoro-4-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 524 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353292&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419750 386047031 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696661 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(N)c1 InChI=1S/C19H20N4O2S/c1-26(24,25)23-9-6-13(7-10-23)18-12-17-16(5-8-21-19(17)22-18)14-3-2-4-15(20)11-14/h2-6,8,11-12H,7,9-10,20H2,1H3,(H,21,22) WZVQBKRSVZZIFK-UHFFFAOYSA-N 353293 3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 525 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353293&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897365 386047032 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696662 CS(=O)(=O)Nc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H22N4O4S2/c1-29(25,26)23-18-6-4-3-5-16(18)15-7-10-21-20-17(15)13-19(22-20)14-8-11-24(12-9-14)30(2,27)28/h3-8,10,13,23H,9,11-12H2,1-2H3,(H,21,22) KQOIQNGDUURHPK-UHFFFAOYSA-N 353294 N-(2-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)methanesulfonamide::US9796708, Example 526 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353294&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420345 386047033 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696663 CC(C)NC(=O)c1cccc(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H26N4O3S/c1-15(2)25-23(28)18-6-4-5-17(13-18)19-7-10-24-22-20(19)14-21(26-22)16-8-11-27(12-9-16)31(3,29)30/h4-8,10,13-15H,9,11-12H2,1-3H3,(H,24,26)(H,25,28) CHBQLKLMFFUVCW-UHFFFAOYSA-N 353295 3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-(propan-2-yl)benzamide::US9796708, Example 527 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2400 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353295&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419762 386047034 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696664 COc1ccc(F)cc1-c1ccnc2[nH]c(N3CCN(CC(=O)N(C)C)CC3)c(C#N)c12 InChI=1S/C23H25FN6O2/c1-28(2)20(31)14-29-8-10-30(11-9-29)23-18(13-25)21-16(6-7-26-22(21)27-23)17-12-15(24)4-5-19(17)32-3/h4-7,12H,8-11,14H2,1-3H3,(H,26,27) YHIYYHANGJNNSU-UHFFFAOYSA-N 353296 2-{4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperazin-1-yl}-N,N-dimethylacetamide::US9796708, Example 528 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353296&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421043 386047035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696665 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(CC#N)cc1 InChI=1S/C21H20N4O2S/c1-28(26,27)25-12-8-17(9-13-25)20-14-19-18(7-11-23-21(19)24-20)16-4-2-15(3-5-16)6-10-22/h2-5,7-8,11,14H,6,9,12-13H2,1H3,(H,23,24) POZULGJAMLBXSX-UHFFFAOYSA-N 353297 (4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)acetonitrile::US9796708, Example 529 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353297&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420464 386047036 C04116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696666 CNC(=O)c1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22N4O3S/c1-22-21(26)16-5-3-14(4-6-16)17-7-10-23-20-18(17)13-19(24-20)15-8-11-25(12-9-15)29(2,27)28/h3-8,10,13H,9,11-12H2,1-2H3,(H,22,26)(H,23,24) UKJYVKJBACYNOC-UHFFFAOYSA-N 353298 N-methyl-4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 530 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353298&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420424 386047037 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696667 CC(=O)Nc1cccc(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22N4O3S/c1-14(26)23-17-5-3-4-16(12-17)18-6-9-22-21-19(18)13-20(24-21)15-7-10-25(11-8-15)29(2,27)28/h3-7,9,12-13H,8,10-11H2,1-2H3,(H,22,24)(H,23,26) CWDHGCBYGUREET-UHFFFAOYSA-N 353299 N-(3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)acetamide::US9796708, Example 531 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420987 386047038 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696668 CC(=O)Nc1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22N4O3S/c1-14(26)23-17-5-3-15(4-6-17)18-7-10-22-21-19(18)13-20(24-21)16-8-11-25(12-9-16)29(2,27)28/h3-8,10,13H,9,11-12H2,1-2H3,(H,22,24)(H,23,26) XBTGYWSZHFHAAF-UHFFFAOYSA-N 353300 N-(4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)acetamide::US9796708, Example 532 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353300&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419755 386047039 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696669 CNS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C20H21FN4O3S/c1-22-29(26,27)25-9-6-13(7-10-25)18-12-17-15(5-8-23-20(17)24-18)16-11-14(21)3-4-19(16)28-2/h3-6,8,11-12,22H,7,9-10H2,1-2H3,(H,23,24) LGEIVLCQGQYWTJ-UHFFFAOYSA-N 353301 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-sulfonamide::US9796708, Example 533 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353301&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897452 386047040 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696670 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccccn2)CC1 InChI=1S/C25H23FN4O/c1-31-24-6-5-18(26)14-21(24)20-7-11-28-25-22(20)15-23(29-25)17-8-12-30(13-9-17)16-19-4-2-3-10-27-19/h2-8,10-11,14-15H,9,12-13,16H2,1H3,(H,28,29) LSFFUPCKIREDGJ-UHFFFAOYSA-N 353302 4-(5-fluoro-2-methoxyphenyl)-2-[1-(pyridin-2-ylmethyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 534 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353302&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419565 386047041 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696671 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(O)CO)C1 353303 3-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 535 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353303&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421830 386047042 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696672 CNC(=O)N1CCC=C(C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H21FN4O2/c1-23-21(27)26-9-3-4-13(12-26)18-11-17-15(7-8-24-20(17)25-18)16-10-14(22)5-6-19(16)28-2/h4-8,10-11H,3,9,12H2,1-2H3,(H,23,27)(H,24,25) XAVCTCREENUMSS-UHFFFAOYSA-N 353304 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 536 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353304&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897196 386047043 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696673 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(C1)S(C)(=O)=O InChI=1S/C20H20FN3O3S/c1-27-19-6-5-14(21)10-16(19)15-7-8-22-20-17(15)11-18(23-20)13-4-3-9-24(12-13)28(2,25)26/h4-8,10-11H,3,9,12H2,1-2H3,(H,22,23) TXCFQUIEHHWUDF-UHFFFAOYSA-N 353305 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,5,6-tetrahydropyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 537 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353305&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419580 386047044 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696674 Cc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O2S/c1-13-3-4-15(21)11-17(13)16-5-8-22-20-18(16)12-19(23-20)14-6-9-24(10-7-14)27(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) ZEIZGZUAFHVJCU-UHFFFAOYSA-N 353306 4-(5-fluoro-2-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 538 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353306&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420939 386047045 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697464 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC[C@@H](O)C2)CC1 InChI=1S/C25H26F2N4O3/c1-34-22-3-2-16(26)10-18(22)24-19-11-21(29-25(19)28-12-20(24)27)15-4-7-30(8-5-15)14-23(33)31-9-6-17(32)13-31/h2-4,10-12,17,32H,5-9,13-14H2,1H3,(H,28,29)/t17-/m1/s1 LQVUPPPWQMXRJJ-QGZVFWFLSA-N 354096 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1 (2H)-yl}-1-[(3R)-3-hydroxypyrrolidin-1-yl]ethanone::US9796708, Example 1328 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354096&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897386 386047828 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697465 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(CC1)C(O)=O InChI=1S/C26H27F2N3O3/c1-34-23-7-4-17(27)12-19(23)24-20-13-22(30-25(20)29-14-21(24)28)15-8-10-31(11-9-15)18-5-2-16(3-6-18)26(32)33/h4,7-8,12-14,16,18H,2-3,5-6,9-11H2,1H3,(H,29,30)(H,32,33) RYPUWZOEFAAXRB-UHFFFAOYSA-N 354097 4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexanecarboxylic acid::US9796708, Example 1329 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354097&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047829 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697466 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(CC(=O)N2CC(O)C2)CC1 354098 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]azepan-1-yl}-1-(3-hydroxyazetidin-1-yl) ethanone::US9796708, Example 1330 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354098&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419932 386047830 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697467 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NC12CC(C1)(C2)C(O)=O 354099 3-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl})amino)bicyclo[1.1.1]pentane-1-carboxylic acid::US9796708, Example 1331 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354099&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897311 386047831 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697468 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCN)CC1 InChI=1S/C21H23FN4O/c1-27-20-3-2-15(22)12-17(20)16-4-8-24-21-18(16)13-19(25-21)14-5-9-26(10-6-14)11-7-23/h2-5,8,12-13H,6-7,9-11,23H2,1H3,(H,24,25) KGJMETNZWPBXBF-UHFFFAOYSA-N 354100 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanamine::US9796708, Example 1332 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354100&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897299 386047832 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697469 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCNS(C)(=O)=O)CC1 InChI=1S/C22H25FN4O3S/c1-30-21-4-3-16(23)13-18(21)17-5-8-24-22-19(17)14-20(26-22)15-6-10-27(11-7-15)12-9-25-31(2,28)29/h3-6,8,13-14,25H,7,9-12H2,1-2H3,(H,24,26) JGCWTADVHJSPBZ-UHFFFAOYSA-N 354101 N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethyl)methanesulfonamide::US9796708, Example 1333 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354101&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421349 386047833 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697470 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCNC(C)=O)CC1 InChI=1S/C23H25FN4O2/c1-15(29)25-9-12-28-10-6-16(7-11-28)21-14-20-18(5-8-26-23(20)27-21)19-13-17(24)3-4-22(19)30-2/h3-6,8,13-14H,7,9-12H2,1-2H3,(H,25,29)(H,26,27) ABZXDARLLCTOAZ-UHFFFAOYSA-N 354102 N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethyl)acetamide::US9796708, Example 1334 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354102&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421407 386047834 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697471 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCS(=O)(=O)N(C)C)CC1 InChI=1S/C23H27FN4O3S/c1-27(2)32(29,30)13-12-28-10-7-16(8-11-28)21-15-20-18(6-9-25-23(20)26-21)19-14-17(24)4-5-22(19)31-3/h4-7,9,14-15H,8,10-13H2,1-3H3,(H,25,26) YSPSFYNHBHANGU-UHFFFAOYSA-N 354103 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylethanesulfonamide::US9796708, Example 1335 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354103&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897487 386047835 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697472 COc1ccc(F)cc1-c1ccnc2[nH]c(N3CCN(CC3)S(C)(=O)=O)c([N+]([O-])=O)c12 InChI=1S/C19H20FN5O5S/c1-30-15-4-3-12(20)11-14(15)13-5-6-21-18-16(13)17(25(26)27)19(22-18)23-7-9-24(10-8-23)31(2,28)29/h3-6,11H,7-10H2,1-2H3,(H,21,22) NPQABNONYHYKJN-UHFFFAOYSA-N 354104 4-(5-fluoro-2-methoxyphenyl)-2-[4-(methylsulfonyl)piperazin-1-yl]-3-nitro-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1336 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354104&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420770 386047836 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697473 COc1ccc(F)cc1-c1ccnc2[nH]c(N3CCN(CC3)S(C)(=O)=O)c(C#N)c12 InChI=1S/C20H20FN5O3S/c1-29-17-4-3-13(21)11-15(17)14-5-6-23-19-18(14)16(12-22)20(24-19)25-7-9-26(10-8-25)30(2,27)28/h3-6,11H,7-10H2,1-2H3,(H,23,24) UEPDMVCCDCXLLL-UHFFFAOYSA-N 354105 4-(5-fluoro-2-methoxyphenyl)-2-[4-(methylsulfonyl)piperazin-1-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1337 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354105&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419931 386047837 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697474 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC2O)C1 354106 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-1-yl}-1-(-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1338 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354106&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 132012197 386047838 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697475 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C1CCN(CC(O)=O)CC1 354107 (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperidin-1-yl)acetic acid::US9796708, Example 1339 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354107&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419912 386047839 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697476 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN([C@@H](C)C1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-13-10-14(7-9-25(13)29(3,26)27)19-12-18-16(6-8-23-21(18)24-19)17-11-15(22)4-5-20(17)28-2/h4-8,11-13H,9-10H2,1-3H3,(H,23,24)/t13-/m0/s1 GWWZXSURAHYRGC-ZDUSSCGKSA-N 354108 4-(5-fluoro-2-methoxyphenyl)-2-[(2S)-2-methyl-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-4-(5-fluoro-2-methoxyphenyl)-2-[(6S)-6-methyl-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1340 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354108&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897216 386047840 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697477 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)CCO)C1 InChI=1S/C23H25FN4O3/c1-27(9-10-29)22(30)14-28-8-6-15(13-28)20-12-19-17(5-7-25-23(19)26-20)18-11-16(24)3-4-21(18)31-2/h3-7,11-12,29H,8-10,13-14H2,1-2H3,(H,25,26) ALQONFSICPGEPM-UHFFFAOYSA-N 354109 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-1-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1341 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354109&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420970 386047841 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697478 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)C1 InChI=1S/C22H23FN4O2/c1-26(2)21(28)13-27-9-7-14(12-27)19-11-18-16(6-8-24-22(18)25-19)17-10-15(23)4-5-20(17)29-3/h4-8,10-11H,9,12-13H2,1-3H3,(H,24,25) PHRYHRUWZWDKEQ-UHFFFAOYSA-N 354110 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-1-yl}-N,N-dimethylacetamide::US9796708, Example 1342 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354110&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420399 386047842 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697479 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2CO)C1 InChI=1S/C25H27FN4O3/c1-33-23-5-4-17(26)11-20(23)19-6-8-27-25-21(19)12-22(28-25)16-7-10-29(13-16)14-24(32)30-9-2-3-18(30)15-31/h4-8,11-12,18,31H,2-3,9-10,13-15H2,1H3,(H,27,28)/t18-/m0/s1 OXXLTJSTMFDMQH-SFHVURJKSA-N 354111 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-1-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1343 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354111&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419517 386047843 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697480 CN(C)C(=O)CN1CCC(CC1)C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1O 354112 2-(4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperidin-1-yl)-N,N-dimethylacetamide::US9796708, Example 1344 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354112&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208182 386047844 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697481 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC[C@H](CC1)C1CCN(CC(O)=O)CC1 InChI=1S/C27H30FN3O3/c1-34-25-7-6-20(28)14-22(25)21-8-11-29-27-23(21)15-24(30-27)19-4-2-17(3-5-19)18-9-12-31(13-10-18)16-26(32)33/h4,6-8,11,14-15,17-18H,2-3,5,9-10,12-13,16H2,1H3,(H,29,30)(H,32,33)/t17-/m1/s1 QMCUOTZYJAWGFD-QGZVFWFLSA-N 354113 (4-{(1S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperidin-1-yl)acetic acid::US9796708, Example 1345 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354113&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897322 386047845 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697482 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC[C@@H](CC1)C1CCN(CC(O)=O)CC1 InChI=1S/C27H30FN3O3/c1-34-25-7-6-20(28)14-22(25)21-8-11-29-27-23(21)15-24(30-27)19-4-2-17(3-5-19)18-9-12-31(13-10-18)16-26(32)33/h4,6-8,11,14-15,17-18H,2-3,5,9-10,12-13,16H2,1H3,(H,29,30)(H,32,33)/t17-/m0/s1 QMCUOTZYJAWGFD-KRWDZBQOSA-N 354114 (4-{(1R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperidin-1-yl)acetic acid::US9796708, Example 1346 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354114&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897444 386047846 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697483 COC(=O)C=C1CCC(CC1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C28H30FN3O3/c1-34-26-8-5-20(29)16-23(26)22-9-12-30-28-24(22)17-25(31-28)19-10-13-32(14-11-19)21-6-3-18(4-7-21)15-27(33)35-2/h5,8-10,12,15-17,21H,3-4,6-7,11,13-14H2,1-2H3,(H,30,31)/b18-15- DIASCPAZYXOCTQ-SDXDJHTJSA-N 354115 US9796708, Example 1347::methyl (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexylidene)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354115&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208183 386047847 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697484 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC[C@H](CC1)N1CCN(CC(O)=O)CC1 InChI=1S/C26H29FN4O3/c1-34-24-7-4-18(27)14-21(24)20-8-9-28-26-22(20)15-23(29-26)17-2-5-19(6-3-17)31-12-10-30(11-13-31)16-25(32)33/h2,4,7-9,14-15,19H,3,5-6,10-13,16H2,1H3,(H,28,29)(H,32,33)/t19-/m1/s1 ULBRYJHARDNUDV-LJQANCHMSA-N 354116 (4-{(1S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperazin-1-yl)acetic acid::US9796708, Example 1348 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354116&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897476 386047848 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697485 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC[C@@H](CC1)N1CCN(CC(O)=O)CC1 InChI=1S/C26H29FN4O3/c1-34-24-7-4-18(27)14-21(24)20-8-9-28-26-22(20)15-23(29-26)17-2-5-19(6-3-17)31-12-10-30(11-13-31)16-25(32)33/h2,4,7-9,14-15,19H,3,5-6,10-13,16H2,1H3,(H,28,29)(H,32,33)/t19-/m0/s1 ULBRYJHARDNUDV-IBGZPJMESA-N 354117 (4-{(1R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperazin-1-yl)acetic acid::US9796708, Example 1349 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354117&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897450 386047849 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697486 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(CC1)=CC(O)=O InChI=1S/C27H28FN3O3/c1-34-25-7-4-19(28)15-22(25)21-8-11-29-27-23(21)16-24(30-27)18-9-12-31(13-10-18)20-5-2-17(3-6-20)14-26(32)33/h4,7-9,11,14-16,20H,2-3,5-6,10,12-13H2,1H3,(H,29,30)(H,32,33)/b17-14- NXNVJHLOCBLLGL-VKAVYKQESA-N 354118 (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexylidene)acetic acid::US9796708, Example 1350 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354118&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420196 386047850 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697487 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC1)C(O)=O 354119 US9796708, Example 1351::cis-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexanecarboxylic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354119&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412403 386047851 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697488 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 354120 US9796708, Example 1352::trans-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexanecarboxylic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354120&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412403 386047852 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697489 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 354121 (cis-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)acetic acid::US9796708, Example 1353 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 105 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354121&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413177 386047853 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697490 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 354122 (trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexyl)acetic acid::US9796708, Example 1354 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354122&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413177 386047854 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697491 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCC(CC(O)=O)CC1 354123 (1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperidin-4-yl)acetic acid::US9796708, Example 1355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354123&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419551 386047855 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697492 COC(=O)C=C1CCC(CC1)N1CCC(=CC1)c1cc2c(c(F)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C28H29F2N3O3/c1-35-25-8-5-19(29)14-21(25)27-22-15-24(32-28(22)31-16-23(27)30)18-9-11-33(12-10-18)20-6-3-17(4-7-20)13-26(34)36-2/h5,8-9,13-16,20H,3-4,6-7,10-12H2,1-2H3,(H,31,32)/b17-13- RDASGVKDKORUQJ-LGMDPLHJSA-N 354124 US9796708, Example 1356::methyl (4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexylidene)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354124&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208184 386047856 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697493 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC1)C(O)=O 354125 US9796708, Example 1357::cis-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexanecarboxylic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354125&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047857 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697494 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 354126 US9796708, Example 1358::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354126&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697495 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(CC1)=CC(O)=O InChI=1S/C27H27F2N3O3/c1-35-24-7-4-18(28)13-20(24)26-21-14-23(31-27(21)30-15-22(26)29)17-8-10-32(11-9-17)19-5-2-16(3-6-19)12-25(33)34/h4,7-8,12-15,19H,2-3,5-6,9-11H2,1H3,(H,30,31)(H,33,34)/b16-12- WNRAJLARYYWJSN-VBKFSLOCSA-N 354127 (4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexylidene)acetic acid::US9796708, Example 1359 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354127&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419964 386047859 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697496 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 354128 (trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}cyclohexyl)acetic acid::US9796708, Example 1360 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354128&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419725 386047860 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697497 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC(=O)NS(=O)(=O)C(C)C)CC1 354129 2-(trans-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)-N-(propan-2-ylsulfonyl)acetamide::US9796708, Example 1361 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354129&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420782 386047861 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697498 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(=O)NS(=O)(=O)C(C)C 354130 US9796708, Example 1362::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(propan-2-ylsulfonyl)cyclohexanecarboxamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354130&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419626 386047862 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697499 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C1CCC(CC(O)=O)CC1 354131 (4-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}cyclohexyl)acetic acid::US9796708, Example 1363 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354131&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419651 386047863 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697500 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C1CCC(CC1)=CC(O)=O 354132 (4-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}cyclohexylidene)acetic acid::US9796708, Example 1364 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354132&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420099 386047864 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696675 Fc1cc(F)cc(COc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2=CCNCC2)c1 InChI=1S/C25H20F3N3O/c26-17-9-15(10-18(27)11-17)14-32-19-1-2-23(28)21(12-19)20-5-8-30-25-22(20)13-24(31-25)16-3-6-29-7-4-16/h1-3,5,8-13,29H,4,6-7,14H2,(H,30,31) NFQCAEGRYHROKE-UHFFFAOYSA-N 353307 4-{5-[(3,5-difluorobenzyl)oxy]-2-fluorophenyl}-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 539 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353307&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420199 386047046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696676 CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(OCc2cc(F)cc(F)c2)ccc1F InChI=1S/C26H22F3N3O/c1-32-8-5-17(6-9-32)25-14-23-21(4-7-30-26(23)31-25)22-13-20(2-3-24(22)29)33-15-16-10-18(27)12-19(28)11-16/h2-5,7,10-14H,6,8-9,15H2,1H3,(H,30,31) RPVZICWQLUXUFB-UHFFFAOYSA-N 353308 4-{5-[(3,5-difluorobenzyl)oxy]-2-fluorophenyl}-2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 540 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353308&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419703 386047047 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696677 OCC(O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(OCc2cc(F)cc(F)c2)ccc1F 353309 3-[4-(4-{5-[(3,5-difluorobenzyl)oxy]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl]propane-1,2-diol::US9796708, Example 541 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420671 386047048 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696678 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(OCc2cc(F)cc(F)c2)ccc1F InChI=1S/C26H22F3N3O3S/c1-36(33,34)32-8-5-17(6-9-32)25-14-23-21(4-7-30-26(23)31-25)22-13-20(2-3-24(22)29)35-15-16-10-18(27)12-19(28)11-16/h2-5,7,10-14H,6,8-9,15H2,1H3,(H,30,31) VXCLVWNKMHGOGP-UHFFFAOYSA-N 353310 4-{5-[(3,5-difluorobenzyl)oxy]-2-fluorophenyl}-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 542 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353310&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420794 386047049 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696679 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(c1)C(N)=O InChI=1S/C20H20N4O3S/c1-28(26,27)24-9-6-13(7-10-24)18-12-17-16(5-8-22-20(17)23-18)14-3-2-4-15(11-14)19(21)25/h2-6,8,11-12H,7,9-10H2,1H3,(H2,21,25)(H,22,23) HHNPCKKDZGJGDH-UHFFFAOYSA-N 353311 3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 543 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 490 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353311&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420377 386047050 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696680 CCOc1ccc(c(C)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H25N3O3S/c1-4-28-17-5-6-18(15(2)13-17)19-7-10-23-22-20(19)14-21(24-22)16-8-11-25(12-9-16)29(3,26)27/h5-8,10,13-14H,4,9,11-12H2,1-3H3,(H,23,24) OSBGEWJVAVXBIS-UHFFFAOYSA-N 353312 4-(4-ethoxy-2-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 544 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353312&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897285 386047051 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696681 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C20H17ClF3N3O2S/c1-30(28,29)27-8-5-12(6-9-27)18-11-15-14(4-7-25-19(15)26-18)13-2-3-17(21)16(10-13)20(22,23)24/h2-5,7,10-11H,6,8-9H2,1H3,(H,25,26) XCIXJTXCGIOENL-UHFFFAOYSA-N 353313 4-[4-chloro-3-(trifluoromethyl)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 545 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353313&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420270 386047052 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696682 CCCCNC(=O)c1cccc(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C24H28N4O3S/c1-3-4-11-26-24(29)19-7-5-6-18(15-19)20-8-12-25-23-21(20)16-22(27-23)17-9-13-28(14-10-17)32(2,30)31/h5-9,12,15-16H,3-4,10-11,13-14H2,1-2H3,(H,25,27)(H,26,29) LPUYCELRUUMYHJ-UHFFFAOYSA-N 353314 N-butyl-3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 546 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353314&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420038 386047053 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696683 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1 InChI=1S/C19H18FN3O2S/c1-26(24,25)23-9-6-13(7-10-23)18-12-17-16(5-8-21-19(17)22-18)14-3-2-4-15(20)11-14/h2-6,8,11-12H,7,9-10H2,1H3,(H,21,22) VBCOOBBLVXVGBU-UHFFFAOYSA-N 353315 4-(3-fluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 547 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353315&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420090 386047054 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696684 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(OCc2cccc(Cl)c2)c(Cl)c1 InChI=1S/C26H23Cl2N3O3S/c1-35(32,33)31-11-8-18(9-12-31)24-15-22-21(7-10-29-26(22)30-24)19-5-6-25(23(28)14-19)34-16-17-3-2-4-20(27)13-17/h2-8,10,13-15H,9,11-12,16H2,1H3,(H,29,30) SOELIRAQXGJYJW-UHFFFAOYSA-N 353316 4-{3-chloro-4-[(3-chlorobenzyl)oxy]phenyl}-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 548 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353316&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419947 386047055 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696685 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O3S/c1-27-19-11-14(21)3-4-16(19)15-5-8-22-20-17(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) ATANMDQMOROSDH-UHFFFAOYSA-N 353317 4-(4-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 549 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353317&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421522 386047056 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696686 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C20H18F3N3O3S/c1-30(27,28)26-10-7-14(8-11-26)18-12-17-16(6-9-24-19(17)25-18)13-2-4-15(5-3-13)29-20(21,22)23/h2-7,9,12H,8,10-11H2,1H3,(H,24,25) XMJOFKNXCFNAQH-UHFFFAOYSA-N 353318 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-[4-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 550 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353318&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420566 386047057 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696687 CC(C)Oc1ccc(cc1Cl)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24ClN3O3S/c1-14(2)29-21-5-4-16(12-19(21)23)17-6-9-24-22-18(17)13-20(25-22)15-7-10-26(11-8-15)30(3,27)28/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,24,25) JXYIPZQCOHUYTE-UHFFFAOYSA-N 353319 4-[3-chloro-4-(propan-2-yloxy)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 551 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 360 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353319&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420354 386047058 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696688 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C19H17Cl2N3O2S/c1-27(25,26)24-6-3-12(4-7-24)18-11-17-16(2-5-22-19(17)23-18)13-8-14(20)10-15(21)9-13/h2-3,5,8-11H,4,6-7H2,1H3,(H,22,23) USLAXFALOJMBMZ-UHFFFAOYSA-N 353320 4-(3,5-dichlorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 552 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4400 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353320&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420064 386047059 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696689 CCCOc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-3-12-29-21-13-16(23)4-5-18(21)17-6-9-24-22-19(17)14-20(25-22)15-7-10-26(11-8-15)30(2,27)28/h4-7,9,13-14H,3,8,10-12H2,1-2H3,(H,24,25) GAMZIRLGTDTKNR-UHFFFAOYSA-N 353321 4-(4-fluoro-2-propoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 553 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 670 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353321&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419542 386047060 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696690 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N1CCOCC1 InChI=1S/C23H25FN4O4S/c1-31-22-3-2-17(24)14-19(22)18-4-7-25-23-20(18)15-21(26-23)16-5-8-27(9-6-16)33(29,30)28-10-12-32-13-11-28/h2-5,7,14-15H,6,8-13H2,1H3,(H,25,26) ISEVZRNNRXRSHY-UHFFFAOYSA-N 353322 4-(5-fluoro-2-methoxyphenyl)-2-[1-(morpholin-4-ylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 554 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353322&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897359 386047061 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696691 COc1ccc(CNc2ccccc2F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C26H25FN4O/c1-32-25-7-6-17(16-30-23-5-3-2-4-22(23)27)14-20(25)19-10-13-29-26-21(19)15-24(31-26)18-8-11-28-12-9-18/h2-8,10,13-15,28,30H,9,11-12,16H2,1H3,(H,29,31) CBENHCYLKKZAJQ-UHFFFAOYSA-N 353323 2-fluoro-N-{4-methoxy-3-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzyl}aniline::US9796708, Example 555 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353323&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897465 386047062 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696692 COc1ccc(CNC2CCOCC2)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C25H30N4O2/c1-30-24-3-2-17(16-28-19-7-12-31-13-8-19)14-21(24)20-6-11-27-25-22(20)15-23(29-25)18-4-9-26-10-5-18/h2-4,6,11,14-15,19,26,28H,5,7-10,12-13,16H2,1H3,(H,27,29) PVQXUXGPZSVRQS-UHFFFAOYSA-N 353324 N-{4-methoxy-3-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzyl}tetrahydro-2H-pyran-4-amine::US9796708, Example 556 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3700 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353324&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420546 386047063 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696693 COc1ccc(CN2CCOCC2)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C24H28N4O2/c1-29-23-3-2-17(16-28-10-12-30-13-11-28)14-20(23)19-6-9-26-24-21(19)15-22(27-24)18-4-7-25-8-5-18/h2-4,6,9,14-15,25H,5,7-8,10-13,16H2,1H3,(H,26,27) HKGFMVYTUAOXLW-UHFFFAOYSA-N 353325 4-[2-methoxy-5-(morpholin-4-ylmethyl)phenyl]-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 557 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353325&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421085 386047064 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696694 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1ccccc1 353326 N-benzyl-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 558 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353326&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897491 386047065 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696695 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1cccc(F)c1 353327 N-(3-fluorobenzyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 559 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 490 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353327&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419752 386047066 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696696 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1cc(F)cc(F)c1 353328 N-(3,5-difluorobenzyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 560 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 670 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353328&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419821 386047067 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696697 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1cc(F)ccc1F 353329 N-(2,5-difluorobenzyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 561 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 770 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353329&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420198 386047068 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696698 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1cccc(Cl)c1 353330 N-(3-chlorobenzyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 562 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 960 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353330&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419780 386047069 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696699 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1ccncc1 353331 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(pyridin-4-ylmethyl)cyclohex-3-ene-1-carboxamide::US9796708, Example 563 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353331&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421433 386047070 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696700 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1cc(C)n[nH]1 353332 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[(3-methyl-1H-pyrazol-5-yl)methyl]cyclohex-3-ene-1-carboxamide::US9796708, Example 564 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353332&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420088 386047071 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696701 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCC1CCOCC1 353333 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(tetrahydro-2H-pyran-4-ylmethyl)cyclohex-3-ene-1-carboxamide::US9796708, Example 565 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353333&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419574 386047072 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696702 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NC1CCC(O)CC1 353334 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(4-hydroxycyclohexyl)cyclohex-3-ene-1-carboxamide::US9796708, Example 566 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420996 386047073 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696703 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)N1CC(F)(F)C1 353335 (3,3-difluoroazetidin-1-yl) {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}methanone::US9796708, Example 567 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353335&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208109 386047074 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696704 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCOCC1 InChI=1S/C19H17FN2O2/c1-23-18-3-2-13(20)10-15(18)14-4-7-21-19-16(14)11-17(22-19)12-5-8-24-9-6-12/h2-5,7,10-11H,6,8-9H2,1H3,(H,21,22) PJVDWZVZPDFIDH-UHFFFAOYSA-N 353336 2-(3,6-dihydro-2H-pyran-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 568 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353336&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421302 386047075 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696705 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)C1CCCOC1 353337 US9796708, Example 569::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(tetrahydro-2H-pyran-3-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353337&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420541 386047076 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696706 OCC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(OCc2cc(F)cc(F)c2)ccc1F InChI=1S/C27H22F3N3O3/c28-18-9-16(10-19(29)11-18)15-36-20-1-2-24(30)22(12-20)21-3-6-31-27-23(21)13-25(32-27)17-4-7-33(8-5-17)26(35)14-34/h1-4,6,9-13,34H,5,7-8,14-15H2,(H,31,32) RKKHXADYMWKBLA-UHFFFAOYSA-N 353338 1-[4-(4-{5-[(3,5-difluorobenzyl)oxy]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl]-2-hydroxyethanone::US9796708, Example 570 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353338&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420136 386047077 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696707 CC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(OCc2cc(F)cc(F)c2)ccc1F InChI=1S/C27H22F3N3O2/c1-16(34)33-8-5-18(6-9-33)26-14-24-22(4-7-31-27(24)32-26)23-13-21(2-3-25(23)30)35-15-17-10-19(28)12-20(29)11-17/h2-5,7,10-14H,6,8-9,15H2,1H3,(H,31,32) IPUPKYIBQAENNJ-UHFFFAOYSA-N 353339 1-[4-(4-{5-[(3,5-difluorobenzyl)oxy]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl]ethanone::US9796708, Example 571 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353339&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420028 386047078 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696708 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(C1)C(=O)CO InChI=1S/C21H20FN3O3/c1-28-19-5-4-14(22)9-16(19)15-6-7-23-21-17(15)10-18(24-21)13-3-2-8-25(11-13)20(27)12-26/h3-7,9-10,26H,2,8,11-12H2,1H3,(H,23,24) AJAIOURTJRNONR-UHFFFAOYSA-N 353340 1-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxyethanone::US9796708, Example 572 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353340&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420272 386047079 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696709 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(C1)C(C)=O InChI=1S/C21H20FN3O2/c1-13(26)25-9-3-4-14(12-25)19-11-18-16(7-8-23-21(18)24-19)17-10-15(22)5-6-20(17)27-2/h4-8,10-11H,3,9,12H2,1-2H3,(H,23,24) HCUHNEPZFNCHIH-UHFFFAOYSA-N 353341 1-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 573 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353341&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897443 386047080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696710 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(Cc2ccc(NC(C)=O)cc2)C1 InChI=1S/C28H27FN4O2/c1-18(34)31-22-8-5-19(6-9-22)16-33-13-3-4-20(17-33)26-15-25-23(11-12-30-28(25)32-26)24-14-21(29)7-10-27(24)35-2/h4-12,14-15H,3,13,16-17H2,1-2H3,(H,30,32)(H,31,34) AAFGVIKUWHAGFS-UHFFFAOYSA-N 353342 N-[4-({5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)phenyl]acetamide::US9796708, Example 574 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353342&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420011 386047081 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696711 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC2CCCO2)C1 353343 4-(5-fluoro-2-methoxyphenyl)-2-[1-(tetrahydrofuran-2-ylmethyl)-1,2,5,6-tetrahydropyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 575 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353343&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897257 386047082 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696712 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(C)(C)O)CC1 InChI=1S/C23H26FN3O2/c1-23(2,28)14-27-10-7-15(8-11-27)20-13-19-17(6-9-25-22(19)26-20)18-12-16(24)4-5-21(18)29-3/h4-7,9,12-13,28H,8,10-11,14H2,1-3H3,(H,25,26) MVQNQPVBMCUAJM-UHFFFAOYSA-N 353344 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-methylpropan-2-ol::US9796708, Example 576 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353344&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419940 386047083 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696713 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C InChI=1S/C22H24N4O2/c1-25(2)22(27)26-12-9-15(10-13-26)19-14-18-16(8-11-23-21(18)24-19)17-6-4-5-7-20(17)28-3/h4-9,11,14H,10,12-13H2,1-3H3,(H,23,24) BEVYHELOXMIXPG-UHFFFAOYSA-N 353345 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 577 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353345&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208110 386047084 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696714 CCOC(=O)NS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H25FN4O5S/c1-3-32-22(28)26-33(29,30)27-10-7-14(8-11-27)19-13-18-16(6-9-24-21(18)25-19)17-12-15(23)4-5-20(17)31-2/h4-6,9,12-14H,3,7-8,10-11H2,1-2H3,(H,24,25)(H,26,28) AVUFSLVVSYVTMX-UHFFFAOYSA-N 353346 US9796708, Example 578::ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353346&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208111 386047085 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696715 CNS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C20H23FN4O3S/c1-22-29(26,27)25-9-6-13(7-10-25)18-12-17-15(5-8-23-20(17)24-18)16-11-14(21)3-4-19(16)28-2/h3-5,8,11-13,22H,6-7,9-10H2,1-2H3,(H,23,24) KOFAYAYWKCMZKA-UHFFFAOYSA-N 353347 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methylpiperidine-1-sulfonamide::US9796708, Example 579 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353347&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421040 386047086 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696716 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(=O)(=O)N(C)C InChI=1S/C21H25FN4O3S/c1-25(2)30(27,28)26-10-7-14(8-11-26)19-13-18-16(6-9-23-21(18)24-19)17-12-15(22)4-5-20(17)29-3/h4-6,9,12-14H,7-8,10-11H2,1-3H3,(H,23,24) UGHOZHDRFKUPNF-UHFFFAOYSA-N 353348 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethylpiperidine-1-sulfonamide::US9796708, Example 580 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353348&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421052 386047087 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696717 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(F)(F)F 353349 4-(5-fluoro-2-methoxyphenyl)-2-[4-(trifluoromethyl)cyclohex-1-en-1-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 581 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353349&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420215 386047088 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696718 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCC1CCOCC1 353350 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(tetrahydro-2H-pyran-4-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 582 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353350&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420021 386047089 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696719 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCS(N)(=O)=O)CC1 InChI=1S/C21H25FN4O3S/c1-29-20-3-2-15(22)12-17(20)16-4-7-24-21-18(16)13-19(25-21)14-5-8-26(9-6-14)10-11-30(23,27)28/h2-4,7,12-14H,5-6,8-11H2,1H3,(H,24,25)(H2,23,27,28) CPJMMTJEPSWSKB-UHFFFAOYSA-N 353351 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanesulfonamide::US9796708, Example 583 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353351&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419597 386047090 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696720 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1ccccc1 353352 N-benzyl-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-amine::US9796708, Example 584 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353352&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897294 386047091 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696721 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1ccncc1 353353 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(pyridin-4-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 585 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353353&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421088 386047092 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696722 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCC1CNCCO1 353354 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(morpholin-2-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 586 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353354&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420696 386047093 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696723 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(C)(=N)=O 353355 4-(5-fluoro-2-methoxyphenyl)-2-[1-(S-methylsulfonimidoyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 587 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353355&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420274 386047094 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696724 CCNS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H25FN4O3S/c1-3-24-30(27,28)26-10-7-14(8-11-26)19-13-18-16(6-9-23-21(18)25-19)17-12-15(22)4-5-20(17)29-2/h4-6,9,12-14,24H,3,7-8,10-11H2,1-2H3,(H,23,25) MBKDXEWBVJSXHS-UHFFFAOYSA-N 353356 N-ethyl-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidine-1-sulfonamide::US9796708, Example 588 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353356&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420133 386047095 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696725 Fc1ccc(Oc2cccc(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)cc1 InChI=1S/C24H22FN3O/c25-18-4-6-19(7-5-18)29-20-3-1-2-17(14-20)21-10-13-27-24-22(21)15-23(28-24)16-8-11-26-12-9-16/h1-7,10,13-16,26H,8-9,11-12H2,(H,27,28) JKYWUXOTMHMNFP-UHFFFAOYSA-N 353357 4-[3-(4-fluorophenoxy)phenyl]-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 589 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353357&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419973 386047096 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696726 Fc1cccc(c1F)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C18H15F2N3/c19-15-3-1-2-13(17(15)20)12-6-9-22-18-14(12)10-16(23-18)11-4-7-21-8-5-11/h1-4,6,9-10,21H,5,7-8H2,(H,22,23) VCWJYSBIJOIPQU-UHFFFAOYSA-N 353358 4-(2,3-difluorophenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 590 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353358&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411403 386047097 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696727 OCC(O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F 353359 3-{4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 591 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353359&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419510 386047098 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696728 CC(=O)Nc1ccc(CN2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cccc(F)c2F)cc1 InChI=1S/C27H24F2N4O/c1-17(34)31-20-7-5-18(6-8-20)16-33-13-10-19(11-14-33)25-15-23-21(9-12-30-27(23)32-25)22-3-2-4-24(28)26(22)29/h2-10,12,15H,11,13-14,16H2,1H3,(H,30,32)(H,31,34) GYVRLFHAJFSZTN-UHFFFAOYSA-N 353360 N-[4-({4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)phenyl]acetamide::US9796708, Example 592 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353360&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420587 386047099 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696729 OCC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C20H17F2N3O2/c21-16-3-1-2-14(19(16)22)13-4-7-23-20-15(13)10-17(24-20)12-5-8-25(9-6-12)18(27)11-26/h1-5,7,10,26H,6,8-9,11H2,(H,23,24) YCEOJPSRSIZHLJ-UHFFFAOYSA-N 353361 1-{4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxyethanone::US9796708, Example 593 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353361&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420476 386047100 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696730 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2 353362 2-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 594 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353362&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414170 386047101 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696731 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1cc(F)cc(F)c1 353363 N-(3,5-difluorobenzyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-amine::US9796708, Example 595 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353363&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421025 386047102 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696732 CNC(=O)N1C2CCC1C=C(C2)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353364 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxamide::US9796708, Example 596 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353364&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419775 386047103 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696733 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(O)CO 353365 3-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}propane-1,2-diol::US9796708, Example 597 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353365&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421476 386047104 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696734 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2C(=O)CO 353366 1-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-2-hydroxyethanone::US9796708, Example 598 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353366&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420201 386047105 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696735 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2C(=O)N(C)C 353367 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethyl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxamide::US9796708, Example 599 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353367&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420504 386047106 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696736 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(=O)(=O)NC[C@H](O)CO InChI=1S/C22H27FN4O5S/c1-32-21-3-2-15(23)10-18(21)17-4-7-24-22-19(17)11-20(26-22)14-5-8-27(9-6-14)33(30,31)25-12-16(29)13-28/h2-4,7,10-11,14,16,25,28-29H,5-6,8-9,12-13H2,1H3,(H,24,26)/t16-/m0/s1 BEBOFNISPDSMFG-INIZCTEOSA-N 353368 N-[(2S)-2,3-dihydroxypropyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidine-1-sulfonamide::US9796708, Example 600 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353368&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420340 386047107 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696737 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3)c(Cl)c12 InChI=1S/C19H19ClFN3O/c1-25-15-3-2-12(21)10-14(15)13-6-9-23-19-16(13)17(20)18(24-19)11-4-7-22-8-5-11/h2-3,6,9-11,22H,4-5,7-8H2,1H3,(H,23,24) QWDSCEPBJKQNGL-UHFFFAOYSA-N 353369 3-chloro-4-(5-fluoro-2-methoxyphenyl)-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 601 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353369&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420989 386047108 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696738 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3)c(Br)c12 InChI=1S/C19H19BrFN3O/c1-25-15-3-2-12(21)10-14(15)13-6-9-23-19-16(13)17(20)18(24-19)11-4-7-22-8-5-11/h2-3,6,9-11,22H,4-5,7-8H2,1H3,(H,23,24) MSIDHBBXOAWUER-UHFFFAOYSA-N 353370 3-bromo-4-(5-fluoro-2-methoxyphenyl)-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 602 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353370&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419848 386047109 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696739 CCOC(=O)NS(=O)(=O)N1CCC(CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1Br InChI=1S/C22H24BrFN4O5S/c1-3-33-22(29)27-34(30,31)28-10-7-13(8-11-28)20-19(23)18-15(6-9-25-21(18)26-20)16-12-14(24)4-5-17(16)32-2/h4-6,9,12-13H,3,7-8,10-11H2,1-2H3,(H,25,26)(H,27,29) BFDXYYQIJSFSDG-UHFFFAOYSA-N 353371 US9796708, Example 603::ethyl ({4-[3-bromo-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353371&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208112 386047110 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696740 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCO InChI=1S/C22H23FN4O3/c1-30-20-3-2-15(23)12-17(20)16-4-7-24-21-18(16)13-19(26-21)14-5-9-27(10-6-14)22(29)25-8-11-28/h2-5,7,12-13,28H,6,8-11H2,1H3,(H,24,26)(H,25,29) XHYLRWISHVNMIG-UHFFFAOYSA-N 353372 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(2-hydroxyethyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 604 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353372&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420786 386047111 C04080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696741 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NS(C)(=O)=O 353373 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(methylsulfonyl)cyclohex-3-ene-1-carboxamide::US9796708, Example 605 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353373&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420341 386047112 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696742 CNC(=O)c1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H20N4O/c1-21-20(25)15-4-2-13(3-5-15)16-8-11-23-19-17(16)12-18(24-19)14-6-9-22-10-7-14/h2-6,8,11-12,22H,7,9-10H2,1H3,(H,21,25)(H,23,24) OKDVOYKSNMQABQ-UHFFFAOYSA-N 353374 N-methyl-4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzamide::US9796708, Example 606 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353374&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419690 386047113 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696743 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(C1)C(=O)N(C)C InChI=1S/C22H23FN4O2/c1-26(2)22(28)27-10-4-5-14(13-27)19-12-18-16(8-9-24-21(18)25-19)17-11-15(23)6-7-20(17)29-3/h5-9,11-12H,4,10,13H2,1-3H3,(H,24,25) BOHLTLWHEHFMTF-UHFFFAOYSA-N 353375 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 607 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353375&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897283 386047114 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696744 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1cccnc1 353376 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(pyridin-3-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 608 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353376&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420761 386047115 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696745 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(N)=O 353377 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 609 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353377&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420942 386047116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696746 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCCC1 InChI=1S/C26H30FN5O2/c1-34-24-5-4-19(27)16-21(24)20-6-9-28-25-22(20)17-23(30-25)18-7-13-32(14-8-18)26(33)29-10-15-31-11-2-3-12-31/h4-7,9,16-17H,2-3,8,10-15H2,1H3,(H,28,30)(H,29,33) QVSHTZGDAFLTLB-UHFFFAOYSA-N 353378 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 610 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353378&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897315 386047117 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696747 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCC(O)CC1 InChI=1S/C27H32FN5O3/c1-36-25-3-2-19(28)16-22(25)21-4-9-29-26-23(21)17-24(31-26)18-5-13-33(14-6-18)27(35)30-10-15-32-11-7-20(34)8-12-32/h2-5,9,16-17,20,34H,6-8,10-15H2,1H3,(H,29,31)(H,30,35) QGLTXTPZTWEJQF-UHFFFAOYSA-N 353379 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(4-hydroxypiperidin-1-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 611 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353379&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420944 386047118 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696748 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCC1CCCO1 353380 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(tetrahydrofuran-2-ylmethyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 612 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353380&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420723 386047119 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696749 COC(=O)N1CCN(CCNC(=O)N2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)CC1 InChI=1S/C28H33FN6O4/c1-38-25-4-3-20(29)17-22(25)21-5-8-30-26-23(21)18-24(32-26)19-6-10-34(11-7-19)27(36)31-9-12-33-13-15-35(16-14-33)28(37)39-2/h3-6,8,17-18H,7,9-16H2,1-2H3,(H,30,32)(H,31,36) LRMCKZLTFFJVGS-UHFFFAOYSA-N 353381 US9796708, Example 613::methyl 4-{2-[({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)amino]ethyl}piperazine-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353381&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897470 386047120 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696750 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCc2ccccc2C1 InChI=1S/C31H32FN5O2/c1-39-29-7-6-24(32)18-26(29)25-8-12-33-30-27(25)19-28(35-30)22-10-15-37(16-11-22)31(38)34-13-17-36-14-9-21-4-2-3-5-23(21)20-36/h2-8,10,12,18-19H,9,11,13-17,20H2,1H3,(H,33,35)(H,34,38) PMRYBOXFBJFQCN-UHFFFAOYSA-N 353382 N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 614 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353382&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419603 386047121 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696751 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCC(C)(C)O InChI=1S/C25H29FN4O3/c1-25(2,32)9-11-28-24(31)30-12-7-16(8-13-30)21-15-20-18(6-10-27-23(20)29-21)19-14-17(26)4-5-22(19)33-3/h4-7,10,14-15,32H,8-9,11-13H2,1-3H3,(H,27,29)(H,28,31) DLGQWNUASMRCEI-UHFFFAOYSA-N 353383 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(3-hydroxy-3-methylbutyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 615 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419903 386047122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696752 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(C)(C)O)C1 InChI=1S/C23H26FN3O2/c1-23(2,28)14-27-10-4-5-15(13-27)20-12-19-17(8-9-25-22(19)26-20)18-11-16(24)6-7-21(18)29-3/h5-9,11-12,28H,4,10,13-14H2,1-3H3,(H,25,26) LJZUWBSXYHEYIX-UHFFFAOYSA-N 353384 1-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-methylpropan-2-ol::US9796708, Example 616 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353384&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421288 386047123 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696753 CNC(=O)c1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353385 4-{2-[1-(2,3-dihydroxypropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-methylbenzamide::US9796708, Example 617 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353385&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420462 386047124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696754 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(cc1)C(=O)NC InChI=1S/C22H23N5O2/c1-23-21(28)16-5-3-14(4-6-16)17-7-10-25-20-18(17)13-19(26-20)15-8-11-27(12-9-15)22(29)24-2/h3-8,10,13H,9,11-12H2,1-2H3,(H,23,28)(H,24,29)(H,25,26) DEVJIKNZEJCXSG-UHFFFAOYSA-N 353386 N-methyl-4-{4-[4-(methylcarbamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 618 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353386&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897246 386047125 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696755 CNC(=O)c1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO InChI=1S/C22H22N4O3/c1-23-22(29)16-4-2-14(3-5-16)17-6-9-24-21-18(17)12-19(25-21)15-7-10-26(11-8-15)20(28)13-27/h2-7,9,12,27H,8,10-11,13H2,1H3,(H,23,29)(H,24,25) IVYQSPRXBBFCPZ-UHFFFAOYSA-N 353387 4-{2-[1-(hydroxyacetyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-methylbenzamide::US9796708, Example 619 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353387&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897310 386047126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696756 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N(C)C InChI=1S/C21H23FN4O3S/c1-25(2)30(27,28)26-10-7-14(8-11-26)19-13-18-16(6-9-23-21(18)24-19)17-12-15(22)4-5-20(17)29-3/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,23,24) VGMBEOPRFNIBAM-UHFFFAOYSA-N 353388 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethyl-3,6-dihydropyridine-1(2H)-sulfonamide::US9796708, Example 620 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353388&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897329 386047127 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696757 COc1ccc(F)cc1-c1ccnc2[nH]c(c(Br)c12)C1=CCNCC1 InChI=1S/C19H17BrFN3O/c1-25-15-3-2-12(21)10-14(15)13-6-9-23-19-16(13)17(20)18(24-19)11-4-7-22-8-5-11/h2-4,6,9-10,22H,5,7-8H2,1H3,(H,23,24) FYYVMOWIOHTLMT-UHFFFAOYSA-N 353389 3-bromo-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 621 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353389&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420978 386047128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696758 COc1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H21N3O2/c1-24-14-3-4-16(19(11-14)25-2)15-7-10-22-20-17(15)12-18(23-20)13-5-8-21-9-6-13/h3-5,7,10-12,21H,6,8-9H2,1-2H3,(H,22,23) ZHVWOQCVBAVFKM-UHFFFAOYSA-N 353390 4-(2,4-dimethoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 622 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353390&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421073 386047129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696759 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCC(O)=O 353391 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}glycine::US9796708, Example 623 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419536 386047130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696760 CNC(=O)C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353392 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methylcyclohex-3-ene-1-carboxamide::US9796708, Example 624 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353392&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421165 386047131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696761 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCC1(O)COC1 InChI=1S/C24H25FN4O4/c1-32-21-3-2-16(25)10-18(21)17-4-7-26-22-19(17)11-20(28-22)15-5-8-29(9-6-15)23(30)27-12-24(31)13-33-14-24/h2-5,7,10-11,31H,6,8-9,12-14H2,1H3,(H,26,28)(H,27,30) XZLAAGPNQITMPA-UHFFFAOYSA-N 353393 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[(3-hydroxyoxetan-3-yl)methyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 625 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421530 386047132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696762 COC(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H22FN3O3/c1-28-20-4-3-15(23)11-17(20)16-5-8-24-22-18(16)12-19(25-22)14-6-9-26(10-7-14)13-21(27)29-2/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,24,25) KMNBZVCKDNQZDA-UHFFFAOYSA-N 353394 US9796708, Example 626::methyl {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353394&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208113 386047133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696763 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H17F2N3O/c1-25-18-10-16(21)15(20)8-13(18)12-4-7-23-19-14(12)9-17(24-19)11-2-5-22-6-3-11/h2,4,7-10,22H,3,5-6H2,1H3,(H,23,24) NQANWEHCZOARIY-UHFFFAOYSA-N 353395 4-(4,5-difluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 627 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353395&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412766 386047134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696764 COc1cc(ccc1-c1ccnc2[nH]c(cc12)C1=CCNCC1)-n1cccn1 InChI=1S/C22H21N5O/c1-28-21-13-16(27-12-2-8-25-27)3-4-18(21)17-7-11-24-22-19(17)14-20(26-22)15-5-9-23-10-6-15/h2-5,7-8,11-14,23H,6,9-10H2,1H3,(H,24,26) UJSBLOLDOLHYOX-UHFFFAOYSA-N 353396 4-[2-methoxy-4-(1H-pyrazol-1-yl)phenyl]-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 628 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353396&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420863 386047135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696765 COc1cccc(OC)c1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H21N3O2/c1-24-17-4-3-5-18(25-2)19(17)14-8-11-22-20-15(14)12-16(23-20)13-6-9-21-10-7-13/h3-6,8,11-12,21H,7,9-10H2,1-2H3,(H,22,23) XOEVDAPBJZCOGR-UHFFFAOYSA-N 353397 4-(2,6-dimethoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 629 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420056 386047136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696766 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H19N3O/c1-23-18-5-3-2-4-15(18)14-8-11-21-19-16(14)12-17(22-19)13-6-9-20-10-7-13/h2-6,8,11-12,20H,7,9-10H2,1H3,(H,21,22) HMOJRMYYKGMPOJ-UHFFFAOYSA-N 353398 4-(2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 630 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353398&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420727 386047137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696767 COc1ccc(Cl)c(c1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H18ClN3O/c1-24-13-2-3-17(20)15(10-13)14-6-9-22-19-16(14)11-18(23-19)12-4-7-21-8-5-12/h2-4,6,9-11,21H,5,7-8H2,1H3,(H,22,23) KSDIEBJEUJQCLX-UHFFFAOYSA-N 353399 4-(2-chloro-5-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 631 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353399&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419649 386047138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696768 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O)C#N InChI=1S/C21H19FN4O3S/c1-29-19-4-3-15(22)9-16(19)20-14(11-23)12-24-21-17(20)10-18(25-21)13-5-7-26(8-6-13)30(2,27)28/h3-5,9-10,12H,6-8H2,1-2H3,(H,24,25) HEZRQSXOLOBZRP-UHFFFAOYSA-N 353400 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 632 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353400&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420308 386047139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696769 CC(C)(O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C22H23F2N3O/c1-22(2,28)13-27-10-7-14(8-11-27)19-12-17-15(6-9-25-21(17)26-19)16-4-3-5-18(23)20(16)24/h3-7,9,12,28H,8,10-11,13H2,1-2H3,(H,25,26) CNQATZHHMPFXKV-UHFFFAOYSA-N 353401 1-{4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-methylpropan-2-ol::US9796708, Example 633 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353401&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419602 386047140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696770 Fc1cccc(c1F)-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccccn2)CC1 InChI=1S/C24H20F2N4/c25-21-6-3-5-19(23(21)26)18-7-11-28-24-20(18)14-22(29-24)16-8-12-30(13-9-16)15-17-4-1-2-10-27-17/h1-8,10-11,14H,9,12-13,15H2,(H,28,29) LTXIODCUOVKOLT-UHFFFAOYSA-N 353402 4-(2,3-difluorophenyl)-2-[1-(pyridin-2-ylmethyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 634 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419658 386047141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696771 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)C(C)(C)O InChI=1S/C23H24FN3O3/c1-23(2,29)22(28)27-10-7-14(8-11-27)19-13-18-16(6-9-25-21(18)26-19)17-12-15(24)4-5-20(17)30-3/h4-7,9,12-13,29H,8,10-11H2,1-3H3,(H,25,26) VNXLREIPDOBDMW-UHFFFAOYSA-N 353403 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxy-2-methylpropan-1-one::US9796708, Example 635 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419852 386047142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696772 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCNCC1)C#N InChI=1S/C20H17FN4O/c1-26-18-3-2-14(21)8-15(18)19-13(10-22)11-24-20-16(19)9-17(25-20)12-4-6-23-7-5-12/h2-4,8-9,11,23H,5-7H2,1H3,(H,24,25) SATASYLEATVVMK-UHFFFAOYSA-N 353404 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 636 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412761 386047143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696773 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2n[nH]c(=O)[nH]2)CC1 InChI=1S/C22H21FN6O2/c1-31-19-3-2-14(23)10-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-29(9-6-13)12-20-26-22(30)28-27-20/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,24,25)(H2,26,27,28,30) FEOULZURPVJZKQ-UHFFFAOYSA-N 353405 5-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one::US9796708, Example 637 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353405&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208114 386047144 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696774 CNC(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O2/c1-24-21(28)13-27-9-6-14(7-10-27)19-12-18-16(5-8-25-22(18)26-19)17-11-15(23)3-4-20(17)29-2/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,24,28)(H,25,26) LULVCCGCZIPWNY-UHFFFAOYSA-N 353406 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-methylacetamide::US9796708, Example 638 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420012 386047145 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696775 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1Br InChI=1S/C22H22BrFN4O5S/c1-3-33-22(29)27-34(30,31)28-10-7-13(8-11-28)20-19(23)18-15(6-9-25-21(18)26-20)16-12-14(24)4-5-17(16)32-2/h4-7,9,12H,3,8,10-11H2,1-2H3,(H,25,26)(H,27,29) OSSZBHJTYYVDEM-UHFFFAOYSA-N 353407 US9796708, Example 639::ethyl ({4-[3-bromo-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208115 386047146 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696776 COc1ccc(F)cc1-c1c(C)cnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-13-12-23-21-17(20(13)16-10-15(22)4-5-19(16)28-2)11-18(24-21)14-6-8-25(9-7-14)29(3,26)27/h4-6,10-12H,7-9H2,1-3H3,(H,23,24) RIXZCEASHRQCCZ-UHFFFAOYSA-N 353408 4-(5-fluoro-2-methoxyphenyl)-5-methyl-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 640 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420085 386047147 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696777 COc1ccc(F)cc1-c1c(C)cnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H20FN3O/c1-12-11-23-20-16(10-17(24-20)13-5-7-22-8-6-13)19(12)15-9-14(21)3-4-18(15)25-2/h3-5,9-11,22H,6-8H2,1-2H3,(H,23,24) DPTRZBFLPUUVBI-UHFFFAOYSA-N 353409 4-(5-fluoro-2-methoxyphenyl)-5-methyl-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 641 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353409&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420698 386047148 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696778 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=NS(=O)(=O)c1ccc(C)cc1 353410 N-[{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(methyl)oxido-λ6-sulfanylidene]-4-methylbenzenesulfonamide::US9796708, Example 642 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208116 386047149 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696779 CCOc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H20FN3O/c1-2-25-19-4-3-14(21)11-16(19)15-7-10-23-20-17(15)12-18(24-20)13-5-8-22-9-6-13/h3-5,7,10-12,22H,2,6,8-9H2,1H3,(H,23,24) MZIMMYJHWFPKEE-UHFFFAOYSA-N 353411 4-(2-ethoxy-5-fluorophenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 643 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353411&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419668 386047150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696780 COc1ccc(OC)c(c1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H21N3O2/c1-24-14-3-4-19(25-2)16(11-14)15-7-10-22-20-17(15)12-18(23-20)13-5-8-21-9-6-13/h3-5,7,10-12,21H,6,8-9H2,1-2H3,(H,22,23) VUYYOHTZTPMEFJ-UHFFFAOYSA-N 353412 4-(2,5-dimethoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 644 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421400 386047151 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696781 COc1ccc(F)cc1-c1ccnc2n(C[C@H](O)CO)c(cc12)C1=CCC(CC1)C(O)=O InChI=1S/C24H25FN2O5/c1-32-22-7-6-16(25)10-19(22)18-8-9-26-23-20(18)11-21(27(23)12-17(29)13-28)14-2-4-15(5-3-14)24(30)31/h2,6-11,15,17,28-29H,3-5,12-13H2,1H3,(H,30,31)/t15?,17-/m0/s1 IMEXWZBTVLYUSA-LWKPJOBUSA-N 353413 N-[(2S)-2,3-dihydroxypropyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxa::US9796708, Example 645 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353413&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208117 386047152 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696782 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(O)CC1 InChI=1S/C25H28FN3O2/c1-31-24-7-2-17(26)14-21(24)20-8-11-27-25-22(20)15-23(28-25)16-9-12-29(13-10-16)18-3-5-19(30)6-4-18/h2,7-9,11,14-15,18-19,30H,3-6,10,12-13H2,1H3,(H,27,28) YWCWBPAMTLAHOW-UHFFFAOYSA-N 353414 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexanol::US9796708, Example 646 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353414&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421016 386047153 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696783 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N1CCC(CC1)C(O)=O InChI=1S/C26H27FN4O4/c1-35-23-3-2-18(27)14-20(23)19-4-9-28-24-21(19)15-22(29-24)16-5-10-30(11-6-16)26(34)31-12-7-17(8-13-31)25(32)33/h2-5,9,14-15,17H,6-8,10-13H2,1H3,(H,28,29)(H,32,33) ZARJDDIJEHXDLE-UHFFFAOYSA-N 353415 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)piperidine-4-carboxylic acid::US9796708, Example 647 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353415&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419630 386047154 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696784 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCC(=O)CC1 InChI=1S/C27H30FN5O3/c1-36-25-3-2-19(28)16-22(25)21-4-9-29-26-23(21)17-24(31-26)18-5-13-33(14-6-18)27(35)30-10-15-32-11-7-20(34)8-12-32/h2-5,9,16-17H,6-8,10-15H2,1H3,(H,29,31)(H,30,35) KCZPRACQXSZYDD-UHFFFAOYSA-N 353416 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(4-oxopiperidin-1-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 648 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353416&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420615 386047155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696785 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCCC(F)(F)C1 InChI=1S/C27H30F3N5O2/c1-37-24-4-3-19(28)15-21(24)20-5-9-31-25-22(20)16-23(33-25)18-6-12-35(13-7-18)26(36)32-10-14-34-11-2-8-27(29,30)17-34/h3-6,9,15-16H,2,7-8,10-14,17H2,1H3,(H,31,33)(H,32,36) ZEZBHAIAKCLZKG-UHFFFAOYSA-N 353417 N-[2-(3,3-difluoropiperidin-1-yl)ethyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 649 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353417&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897259 386047156 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696786 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCCC(O)C1 353418 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(3-hydroxypiperidin-1-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 650 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353418&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420553 386047157 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696787 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CC[C@H](O)C1 InChI=1S/C26H30FN5O3/c1-35-24-3-2-18(27)14-21(24)20-4-8-28-25-22(20)15-23(30-25)17-5-11-32(12-6-17)26(34)29-9-13-31-10-7-19(33)16-31/h2-5,8,14-15,19,33H,6-7,9-13,16H2,1H3,(H,28,30)(H,29,34)/t19-/m0/s1 WLYYHUJWUWPLMW-IBGZPJMESA-N 353419 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 651 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353419&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897432 386047158 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696788 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN(C)CCO InChI=1S/C25H30FN5O3/c1-30(13-14-32)12-9-28-25(33)31-10-6-17(7-11-31)22-16-21-19(5-8-27-24(21)29-22)20-15-18(26)3-4-23(20)34-2/h3-6,8,15-16,32H,7,9-14H2,1-2H3,(H,27,29)(H,28,33) JWIXWSNIWCHYRC-UHFFFAOYSA-N 353420 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(2-hydroxyethyl)(methyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 652 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897256 386047159 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696789 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCN(CCO)CC1 InChI=1S/C28H35FN6O3/c1-38-26-3-2-21(29)18-23(26)22-4-7-30-27-24(22)19-25(32-27)20-5-9-35(10-6-20)28(37)31-8-11-33-12-14-34(15-13-33)16-17-36/h2-5,7,18-19,36H,6,8-17H2,1H3,(H,30,32)(H,31,37) JMGSAEIYMFBKEZ-UHFFFAOYSA-N 353421 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 653 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353421&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420973 386047160 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696790 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCNC(=O)C1 InChI=1S/C26H29FN6O3/c1-36-23-3-2-18(27)14-20(23)19-4-7-29-25-21(19)15-22(31-25)17-5-10-33(11-6-17)26(35)30-9-13-32-12-8-28-24(34)16-32/h2-5,7,14-15H,6,8-13,16H2,1H3,(H,28,34)(H,29,31)(H,30,35) GNEQNTJZKWJBFZ-UHFFFAOYSA-N 353422 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(3-oxopiperazin-1-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 654 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353422&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421115 386047161 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696791 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCC[C@H](O)C1 InChI=1S/C27H32FN5O3/c1-36-25-5-4-19(28)15-22(25)21-6-9-29-26-23(21)16-24(31-26)18-7-12-33(13-8-18)27(35)30-10-14-32-11-2-3-20(34)17-32/h4-7,9,15-16,20,34H,2-3,8,10-14,17H2,1H3,(H,29,31)(H,30,35)/t20-/m0/s1 MAEMIPSGUMQXIC-FQEVSTJZSA-N 353423 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(3S)-3-hydroxypiperidin-1-yl]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 655 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353423&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420771 386047162 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696792 COc1ccc(cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1)C#N InChI=1S/C20H18N4O/c1-25-19-3-2-13(12-21)10-16(19)15-6-9-23-20-17(15)11-18(24-20)14-4-7-22-8-5-14/h2-4,6,9-11,22H,5,7-8H2,1H3,(H,23,24) PNWCWKASHHTKJI-UHFFFAOYSA-N 353424 4-methoxy-3-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzonitrile::US9796708, Example 656 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353424&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419710 386047163 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696793 Fc1ccc(Cl)c(c1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C18H15ClFN3/c19-16-2-1-12(20)9-14(16)13-5-8-22-18-15(13)10-17(23-18)11-3-6-21-7-4-11/h1-3,5,8-10,21H,4,6-7H2,(H,22,23) FUMGXAXNPKZGRL-UHFFFAOYSA-N 353425 4-(2-chloro-5-fluorophenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 657 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353425&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420452 386047164 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696794 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H18FN3O/c1-24-18-10-13(20)2-3-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-4,6,9-11,21H,5,7-8H2,1H3,(H,22,23) TULRZKQMZHPFPA-UHFFFAOYSA-N 353426 4-(4-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 658 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420598 386047165 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696795 FC(F)Oc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H16F3N3O/c20-12-1-2-17(26-19(21)22)14(9-12)13-5-8-24-18-15(13)10-16(25-18)11-3-6-23-7-4-11/h1-3,5,8-10,19,23H,4,6-7H2,(H,24,25) KLHIKJKCGWAAII-UHFFFAOYSA-N 353427 4-[2-(difluoromethoxy)-5-fluorophenyl]-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 659 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353427&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419865 386047166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696796 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CC(O)=O InChI=1S/C21H20FN3O5S/c1-30-19-3-2-14(22)10-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)31(28,29)12-20(26)27/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,23,24)(H,26,27) KUZNPFHOGLDLKK-UHFFFAOYSA-N 353428 ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)acetic acid::US9796708, Example 660 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353428&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420483 386047167 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696797 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CS(C)(=O)=O InChI=1S/C21H22FN3O5S2/c1-30-20-4-3-15(22)11-17(20)16-5-8-23-21-18(16)12-19(24-21)14-6-9-25(10-7-14)32(28,29)13-31(2,26)27/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,23,24) HFYYNNDQXJIVAM-UHFFFAOYSA-N 353429 4-(5-fluoro-2-methoxyphenyl)-2-(1-{[(methylsulfonyl)methyl]sulfonyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 661 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353429&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420371 386047168 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696798 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H17ClFN3O/c1-25-17-3-2-12(21)8-13(17)18-14-9-16(11-4-6-22-7-5-11)24-19(14)23-10-15(18)20/h2-4,8-10,22H,5-7H2,1H3,(H,23,24) IIAWNYSOHBISIO-UHFFFAOYSA-N 353430 5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 662 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353430&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420279 386047169 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696799 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CC1CCCO1 353431 4-(5-fluoro-2-methoxyphenyl)-2-{1-[(tetrahydrofuran-2-ylmethyl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridin::US9796708, Example 663 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353431&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897330 386047170 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696800 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(c(C)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H25FN4O5S/c1-4-33-23(29)27-34(30,31)28-9-7-15(8-10-28)19-12-18-21(14(2)13-25-22(18)26-19)17-11-16(24)5-6-20(17)32-3/h5-7,11-13H,4,8-10H2,1-3H3,(H,25,26)(H,27,29) LNIUXGLUMBWMPX-UHFFFAOYSA-N 353432 US9796708, Example 664::ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-5-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353432&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208118 386047171 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696801 COc1ccc(F)cc1-c1ccnc2[nH]c(c(Cl)c12)C1=CCNCC1 InChI=1S/C19H17ClFN3O/c1-25-15-3-2-12(21)10-14(15)13-6-9-23-19-16(13)17(20)18(24-19)11-4-7-22-8-5-11/h2-4,6,9-10,22H,5,7-8H2,1H3,(H,23,24) ZFHLCKJNUFTHPI-UHFFFAOYSA-N 353433 3-chloro-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 665 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353433&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420855 386047172 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696802 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1Cl InChI=1S/C22H22ClFN4O5S/c1-3-33-22(29)27-34(30,31)28-10-7-13(8-11-28)20-19(23)18-15(6-9-25-21(18)26-20)16-12-14(24)4-5-17(16)32-2/h4-7,9,12H,3,8,10-11H2,1-2H3,(H,25,26)(H,27,29) ZNFKMVYNYLEKOA-UHFFFAOYSA-N 353434 US9796708, Example 666::ethyl ({4-[3-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353434&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208119 386047173 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696803 COc1ccc(F)cc1-c1ccnc2[nH]c(c(Cl)c12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H19ClFN3O3S/c1-28-16-4-3-13(22)11-15(16)14-5-8-23-20-17(14)18(21)19(24-20)12-6-9-25(10-7-12)29(2,26)27/h3-6,8,11H,7,9-10H2,1-2H3,(H,23,24) FQSPEBLFPOMWNB-UHFFFAOYSA-N 353435 3-chloro-4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 667 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353435&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419625 386047174 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696804 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 353436 (cis-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}cyclohexyl)acetic acid::US9796708, Example 668 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353436&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419725 386047175 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696805 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1ccccn1 353437 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(pyridin-2-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 669 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353437&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420856 386047176 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696806 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1cnccn1 353438 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(pyrazin-2-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 670 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353438&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420625 386047177 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696807 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1cncnc1 353439 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(pyrimidin-5-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 671 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353439&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420627 386047178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696808 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCC1CCCO1 353440 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(tetrahydrofuran-2-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 672 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353440&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420960 386047179 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696809 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H18FN3O/c1-24-18-3-2-13(20)10-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-4,6,9-11,21H,5,7-8H2,1H3,(H,22,23) BHDZLFHFYYIDMB-UHFFFAOYSA-N 167602 US9073922, 87::US9796708, Example 87 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167602&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411400 312321447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696810 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H21FN4O2/c1-23-21(27)26-9-6-13(7-10-26)18-12-17-15(5-8-24-20(17)25-18)16-11-14(22)3-4-19(16)28-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,27)(H,24,25) ZPUBPIPZFAUDSS-UHFFFAOYSA-N 167728 US9073922, 215::US9796708, Example 215 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167728&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 81689869 312321572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696811 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O3S/c1-27-19-4-3-14(21)11-16(19)15-5-8-22-20-17(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) SRPJBGDXQQBRRD-UHFFFAOYSA-N 167633 US9073922, 119::US9796708, Example 119 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167633&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412625 312321478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696812 COC(=O)C(C)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353444 US9796708, Example 676::methyl 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propanoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353444&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420441 386047183 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696813 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H19ClFN3O3S/c1-28-18-4-3-13(22)9-14(18)19-15-10-17(24-20(15)23-11-16(19)21)12-5-7-25(8-6-12)29(2,26)27/h3-5,9-11H,6-8H2,1-2H3,(H,23,24) QCHXBPHKMRUGHI-UHFFFAOYSA-N 353445 5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 677 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420883 386047184 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696814 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@@H]1OC(C)(C)OC1(C)C InChI=1S/C27H30FN3O4/c1-26(2)23(34-27(3,4)35-26)25(32)31-12-9-16(10-13-31)21-15-20-18(8-11-29-24(20)30-21)19-14-17(28)6-7-22(19)33-5/h6-9,11,14-15,23H,10,12-13H2,1-5H3,(H,29,30)/t23-/m0/s1 FHJMHHUWRFLJDF-QHCPKHFHSA-N 353446 US9796708, Example 678::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}[(4R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897494 386047185 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696815 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CN(CCC1C(O)=O)S(C)(=O)=O 353447 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(methylsulfonyl)-1,2,3,4-tetrahydropyridine-4-carboxylic acid::US9796708, Example 679 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353447&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897212 386047186 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696816 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@H]1OC(C)(C)OC1(C)C InChI=1S/C27H30FN3O4/c1-26(2)23(34-27(3,4)35-26)25(32)31-12-9-16(10-13-31)21-15-20-18(8-11-29-24(20)30-21)19-14-17(28)6-7-22(19)33-5/h6-9,11,14-15,23H,10,12-13H2,1-5H3,(H,29,30)/t23-/m1/s1 FHJMHHUWRFLJDF-HSZRJFAPSA-N 353448 US9796708, Example 680::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353448&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897304 386047187 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696817 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(C)C(O)=O 353449 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propanoic acid::US9796708, Example 681 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897204 386047188 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696818 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(=CC1)C(O)=O 353450 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohex-1-ene-1-carboxylic acid::US9796708, Example 682 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353450&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421253 386047189 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696819 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC2CC(CC(O)=O)CC2C1 353451 US9796708, Example 683::[(2s,3aR,5r,6aS)-5-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}octahydropentalen-2-yl]acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 390 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353451&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208120 386047190 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696820 COC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H21FN4O5S/c1-30-19-4-3-14(22)11-16(19)15-5-8-23-20-17(15)12-18(24-20)13-6-9-26(10-7-13)32(28,29)25-21(27)31-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,24)(H,25,27) UQQWPPBBPYWBIO-UHFFFAOYSA-N 353452 US9796708, Example 684::methyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353452&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208121 386047191 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696821 COC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1Cl InChI=1S/C21H20ClFN4O5S/c1-31-16-4-3-13(23)11-15(16)14-5-8-24-20-17(14)18(22)19(25-20)12-6-9-27(10-7-12)33(29,30)26-21(28)32-2/h3-6,8,11H,7,9-10H2,1-2H3,(H,24,25)(H,26,28) JTKQZTMMNZEGET-UHFFFAOYSA-N 353453 US9796708, Example 685::methyl ({4-[3-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353453&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208122 386047192 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696822 CNC(=O)c1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H21FN4O3S/c1-23-21(27)16-4-3-14(11-18(16)22)15-5-8-24-20-17(15)12-19(25-20)13-6-9-26(10-7-13)30(2,28)29/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,27)(H,24,25) RIXVBQKQIBRKOH-UHFFFAOYSA-N 353454 2-fluoro-N-methyl-4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 686 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 72.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419982 386047193 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696823 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@@H](O)C(C)(C)O InChI=1S/C24H26FN3O4/c1-24(2,31)21(29)23(30)28-10-7-14(8-11-28)19-13-18-16(6-9-26-22(18)27-19)17-12-15(25)4-5-20(17)32-3/h4-7,9,12-13,21,29,31H,8,10-11H2,1-3H3,(H,26,27)/t21-/m1/s1 VFTJLUCHSRRFAH-OAQYLSRUSA-N 353455 (2S)-1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2,3-dihydroxy-3-methylbutan-1-one::US9796708, Example 687 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353455&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420575 386047194 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696824 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@H](O)C(C)(C)O InChI=1S/C24H26FN3O4/c1-24(2,31)21(29)23(30)28-10-7-14(8-11-28)19-13-18-16(6-9-26-22(18)27-19)17-12-15(25)4-5-20(17)32-3/h4-7,9,12-13,21,29,31H,8,10-11H2,1-3H3,(H,26,27)/t21-/m0/s1 VFTJLUCHSRRFAH-NRFANRHFSA-N 353456 (2R)-1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2,3-dihydroxy-3-methylbutan-1-one::US9796708, Example 688 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420517 386047195 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696825 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO)C#N InChI=1S/C22H19FN4O3/c1-30-19-3-2-15(23)8-16(19)21-14(10-24)11-25-22-17(21)9-18(26-22)13-4-6-27(7-5-13)20(29)12-28/h2-4,8-9,11,28H,5-7,12H2,1H3,(H,25,26) HGOLCYFCMMBOIK-UHFFFAOYSA-N 353457 4-(5-fluoro-2-methoxyphenyl)-2-[1-(hydroxyacetyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 689 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353457&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420237 386047196 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696826 CNC(=O)N1CCC(=CC1)c1cc2c(c(cnc2[nH]1)C#N)-c1cc(F)ccc1OC InChI=1S/C22H20FN5O2/c1-25-22(29)28-7-5-13(6-8-28)18-10-17-20(14(11-24)12-26-21(17)27-18)16-9-15(23)3-4-19(16)30-2/h3-5,9-10,12H,6-8H2,1-2H3,(H,25,29)(H,26,27) MELHJDRHXGUYQH-UHFFFAOYSA-N 353458 4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 690 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421017 386047197 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696827 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCNCC1 InChI=1S/C26H31FN6O2/c1-35-24-3-2-19(27)16-21(24)20-4-7-29-25-22(20)17-23(31-25)18-5-11-33(12-6-18)26(34)30-10-15-32-13-8-28-9-14-32/h2-5,7,16-17,28H,6,8-15H2,1H3,(H,29,31)(H,30,34) BKPFQCXCOPYDFO-UHFFFAOYSA-N 353459 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(piperazin-1-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 691 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353459&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420466 386047198 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696828 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCC(N)CC1 InChI=1S/C27H33FN6O2/c1-36-25-3-2-19(28)16-22(25)21-4-9-30-26-23(21)17-24(32-26)18-5-13-34(14-6-18)27(35)31-10-15-33-11-7-20(29)8-12-33/h2-5,9,16-17,20H,6-8,10-15,29H2,1H3,(H,30,32)(H,31,35) GSLHBGXLBAOFGK-UHFFFAOYSA-N 353460 N-[2-(4-aminopiperidin-1-yl)ethyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 692 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897224 386047199 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696829 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNC(CO)CO InChI=1S/C25H30FN5O4/c1-35-23-3-2-17(26)12-20(23)19-4-7-28-24-21(19)13-22(30-24)16-5-10-31(11-6-16)25(34)29-9-8-27-18(14-32)15-33/h2-5,7,12-13,18,27,32-33H,6,8-11,14-15H2,1H3,(H,28,30)(H,29,34) WVDXRQVWQYIPQP-UHFFFAOYSA-N 353461 N-{2-[(1,3-dihydroxypropan-2-yl)amino]ethyl}-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 693 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353461&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419763 386047200 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696830 CCOc1c(N2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)c(=O)c1=O InChI=1S/C25H22FN3O4/c1-3-33-24-21(22(30)23(24)31)29-10-7-14(8-11-29)19-13-18-16(6-9-27-25(18)28-19)17-12-15(26)4-5-20(17)32-2/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,27,28) QFAMQGSLKNRNLR-UHFFFAOYSA-N 353462 3-ethoxy-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobut-3-ene-1,2-dione::US9796708, Example 694 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208123 386047201 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696831 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H17F2N3O/c1-25-17-3-2-12(20)8-13(17)18-14-9-16(11-4-6-22-7-5-11)24-19(14)23-10-15(18)21/h2-4,8-10,22H,5-7H2,1H3,(H,23,24) ZNDUXIFKRVMQJQ-UHFFFAOYSA-N 353463 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 695 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412326 386047202 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696832 CNC(=O)N1CCC(=CC1)c1cc2c(c(F)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H20F2N4O2/c1-24-21(28)27-7-5-12(6-8-27)17-10-15-19(16(23)11-25-20(15)26-17)14-9-13(22)3-4-18(14)29-2/h3-5,9-11H,6-8H2,1-2H3,(H,24,28)(H,25,26) WEKFCHIFUYEDOU-UHFFFAOYSA-N 353464 4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 696 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353464&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420797 386047203 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696833 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H19F2N3O3S/c1-28-18-4-3-13(21)9-14(18)19-15-10-17(24-20(15)23-11-16(19)22)12-5-7-25(8-6-12)29(2,26)27/h3-5,9-11H,6-8H2,1-2H3,(H,23,24) WNNCPXCYBZTNCH-UHFFFAOYSA-N 353465 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 697 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353465&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419558 386047204 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696834 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353466 3-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 698 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353466&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897317 386047205 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696835 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CS(C)(=O)=O InChI=1S/C22H22FN3O4S/c1-30-20-4-3-15(23)11-17(20)16-5-8-24-22-18(16)12-19(25-22)14-6-9-26(10-7-14)21(27)13-31(2,28)29/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,24,25) BIPGWGONHLDXMK-UHFFFAOYSA-N 353467 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-(methylsulfonyl)ethanone::US9796708, Example 699 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353467&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897490 386047206 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696836 CCOC(=O)CC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C24H24FN3O4/c1-3-32-23(30)14-22(29)28-10-7-15(8-11-28)20-13-19-17(6-9-26-24(19)27-20)18-12-16(25)4-5-21(18)31-2/h4-7,9,12-13H,3,8,10-11,14H2,1-2H3,(H,26,27) WNSMACLBHAEXTB-UHFFFAOYSA-N 353468 US9796708, Example 700::ethyl 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-oxopropanoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353468&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421137 386047207 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696837 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)Nc1cnn(CCS(C)(=O)=O)c1 InChI=1S/C26H27FN6O4S/c1-37-24-4-3-18(27)13-21(24)20-5-8-28-25-22(20)14-23(31-25)17-6-9-32(10-7-17)26(34)30-19-15-29-33(16-19)11-12-38(2,35)36/h3-6,8,13-16H,7,9-12H2,1-2H3,(H,28,31)(H,30,34) KBOZLNYFJSCSBN-UHFFFAOYSA-N 353469 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{1-[2-(methylsulfonyl)ethyl]-1H-pyrazol-4-yl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 701 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353469&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421708 386047208 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696838 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CNS(C)(=O)=O InChI=1S/C22H23FN4O4S/c1-31-20-4-3-15(23)11-17(20)16-5-8-24-22-18(16)12-19(26-22)14-6-9-27(10-7-14)21(28)13-25-32(2,29)30/h3-6,8,11-12,25H,7,9-10,13H2,1-2H3,(H,24,26) LOQLJJWKOQEJSY-UHFFFAOYSA-N 353470 N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)methanesulfonamide::US9796708, Example 702 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419608 386047209 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696839 OC(=O)C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F 353471 4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 703 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353471&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420865 386047210 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696840 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCC(O)=O 353472 N-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}carbonyl)glycine::US9796708, Example 704 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353472&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419683 386047211 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696841 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC(O)=O InChI=1S/C22H20FN3O4/c1-30-19-3-2-14(23)10-16(19)15-4-7-24-22-17(15)11-18(25-22)13-5-8-26(9-6-13)20(27)12-21(28)29/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,24,25)(H,28,29) QJAMFTDBVNODRP-UHFFFAOYSA-N 353473 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-oxopropanoic acid::US9796708, Example 705 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353473&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419575 386047212 C01656 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696842 COc1cc(Cl)ccc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H18ClN3O/c1-24-18-10-13(20)2-3-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-4,6,9-11,21H,5,7-8H2,1H3,(H,22,23) OJFNDWDOMYTIKQ-UHFFFAOYSA-N 353474 4-(4-chloro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 706 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353474&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421204 386047213 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696843 COc1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H23N3O4S/c1-27-15-4-5-17(20(12-15)28-2)16-6-9-22-21-18(16)13-19(23-21)14-7-10-24(11-8-14)29(3,25)26/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,22,23) NLWFWNMMWKDBON-UHFFFAOYSA-N 353475 4-(2,4-dimethoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 707 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353475&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420317 386047214 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696844 COc1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353476 3-{4-[4-(2,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 708 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353476&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897223 386047215 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696845 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(OC)cc1OC InChI=1S/C22H24N4O3/c1-23-22(27)26-10-7-14(8-11-26)19-13-18-16(6-9-24-21(18)25-19)17-5-4-15(28-2)12-20(17)29-3/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,23,27)(H,24,25) WVHLFAFESIVKJQ-UHFFFAOYSA-N 353477 4-[4-(2,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 709 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353477&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420295 386047216 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696846 COc1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO InChI=1S/C22H23N3O4/c1-28-15-3-4-17(20(11-15)29-2)16-5-8-23-22-18(16)12-19(24-22)14-6-9-25(10-7-14)21(27)13-26/h3-6,8,11-12,26H,7,9-10,13H2,1-2H3,(H,23,24) IUUNHWUMLWZNLJ-UHFFFAOYSA-N 353478 1-{4-[4-(2,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxyethanone::US9796708, Example 710 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353478&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419861 386047217 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696847 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353479 3-{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 711 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353479&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419938 386047218 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696848 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1OC InChI=1S/C21H22N4O2/c1-22-21(26)25-11-8-14(9-12-25)18-13-17-15(7-10-23-20(17)24-18)16-5-3-4-6-19(16)27-2/h3-8,10,13H,9,11-12H2,1-2H3,(H,22,26)(H,23,24) JPVGLBMPNLVXTF-UHFFFAOYSA-N 353480 4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 712 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421081 386047219 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696849 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO InChI=1S/C21H21N3O3/c1-27-19-5-3-2-4-16(19)15-6-9-22-21-17(15)12-18(23-21)14-7-10-24(11-8-14)20(26)13-25/h2-7,9,12,25H,8,10-11,13H2,1H3,(H,22,23) GCVSAIBJMFPDAT-UHFFFAOYSA-N 353481 2-hydroxy-1-{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 713 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353481&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897240 386047220 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696850 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353482 3-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 714 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353482&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897424 386047221 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696851 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(F)cc1OC InChI=1S/C21H21FN4O2/c1-23-21(27)26-9-6-13(7-10-26)18-12-17-15(5-8-24-20(17)25-18)16-4-3-14(22)11-19(16)28-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,27)(H,24,25) DRSLRFNUNARLGD-UHFFFAOYSA-N 353483 4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 715 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353483&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897289 386047222 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696852 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO InChI=1S/C21H20FN3O3/c1-28-19-10-14(22)2-3-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)20(27)12-26/h2-5,7,10-11,26H,6,8-9,12H2,1H3,(H,23,24) NCAZCTAHBWLXRD-UHFFFAOYSA-N 353484 1-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxyethanone::US9796708, Example 716 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353484&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420122 386047223 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696853 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353485 3-{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 717 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353485&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897400 386047224 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696854 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO InChI=1S/C21H19F2N3O3/c1-29-19-10-17(23)16(22)8-14(19)13-2-5-24-21-15(13)9-18(25-21)12-3-6-26(7-4-12)20(28)11-27/h2-3,5,8-10,27H,4,6-7,11H2,1H3,(H,24,25) URZOZAKWYRNYHQ-UHFFFAOYSA-N 353486 1-{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxyethanone::US9796708, Example 718 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353486&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420249 386047225 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696855 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(C)=O InChI=1S/C21H21FN4O4S/c1-13(27)25-31(28,29)26-9-6-14(7-10-26)19-12-18-16(5-8-23-21(18)24-19)17-11-15(22)3-4-20(17)30-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,24)(H,25,27) PZRQHAPGOFEPMH-UHFFFAOYSA-N 353487 N-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)acetamide::US9796708, Example 719 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353487&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420194 386047226 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696856 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H19F2N3O3S/c1-28-19-11-17(22)16(21)9-14(19)13-3-6-23-20-15(13)10-18(24-20)12-4-7-25(8-5-12)29(2,26)27/h3-4,6,9-11H,5,7-8H2,1-2H3,(H,23,24) UBQDSVULQVOWHQ-UHFFFAOYSA-N 353488 4-(4,5-difluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 720 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353488&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420289 386047227 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696857 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C)c12)C1=CCNCC1 InChI=1S/C20H20FN3O/c1-12-18-15(16-11-14(21)3-4-17(16)25-2)7-10-23-20(18)24-19(12)13-5-8-22-9-6-13/h3-5,7,10-11,22H,6,8-9H2,1-2H3,(H,23,24) JVOXDNVYEFAKOX-UHFFFAOYSA-N 353489 4-(5-fluoro-2-methoxyphenyl)-3-methyl-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 721 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353489&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420869 386047228 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696858 Fc1cccc(c1F)-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2 353490 2-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 722 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353490&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420283 386047229 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696859 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1)C#N InChI=1S/C22H19FN4O3/c1-30-19-3-2-15(23)8-16(19)21-14(10-24)11-25-22-17(21)9-18(26-22)13-4-6-27(7-5-13)12-20(28)29/h2-4,8-9,11H,5-7,12H2,1H3,(H,25,26)(H,28,29) OMZRLNQTXZTTIG-UHFFFAOYSA-N 353491 US9796708, Example 723::{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353491&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413291 386047230 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696860 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCCc1c[nH]cn1 InChI=1S/C27H30FN7O2/c1-37-25-3-2-19(28)14-22(25)21-5-9-31-26-23(21)15-24(34-26)18-6-12-35(13-7-18)27(36)32-11-10-29-8-4-20-16-30-17-33-20/h2-3,5-6,9,14-17,29H,4,7-8,10-13H2,1H3,(H,30,33)(H,31,34)(H,32,36) GOZNFVUNZJXYPR-UHFFFAOYSA-N 353492 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(2-{[2-(1H-imidazol-4-yl)ethyl]amino}ethyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 724 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353492&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421311 386047231 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696861 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCC(C)O 353493 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(2-hydroxypropyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 725 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353493&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420035 386047232 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696862 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN(C)C InChI=1S/C24H28FN5O2/c1-29(2)13-10-27-24(31)30-11-7-16(8-12-30)21-15-20-18(6-9-26-23(20)28-21)19-14-17(25)4-5-22(19)32-3/h4-7,9,14-15H,8,10-13H2,1-3H3,(H,26,28)(H,27,31) HSBWSYHWILBSBW-UHFFFAOYSA-N 353494 N-[2-(dimethylamino)ethyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 726 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353494&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419673 386047233 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696863 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCC1(C)COC1 InChI=1S/C27H32FN5O3/c1-27(16-36-17-27)15-29-9-10-31-26(34)33-11-6-18(7-12-33)23-14-22-20(5-8-30-25(22)32-23)21-13-19(28)3-4-24(21)35-2/h3-6,8,13-14,29H,7,9-12,15-17H2,1-2H3,(H,30,32)(H,31,34) KJPFZQNNBCRSQN-UHFFFAOYSA-N 353495 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(2-{[(3-methyloxetan-3-yl)methyl]amino}ethyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 727 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353495&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420265 386047234 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696864 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNC1COC1 InChI=1S/C25H28FN5O3/c1-33-23-3-2-17(26)12-20(23)19-4-7-28-24-21(19)13-22(30-24)16-5-10-31(11-6-16)25(32)29-9-8-27-18-14-34-15-18/h2-5,7,12-13,18,27H,6,8-11,14-15H2,1H3,(H,28,30)(H,29,32) TVPWPSLEFAEWOZ-UHFFFAOYSA-N 353496 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(oxetan-3-ylamino)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 728 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353496&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420494 386047235 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696865 CNC(=O)c1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C21H22N4O2/c1-22-21(26)14-3-4-16(19(11-14)27-2)15-7-10-24-20-17(15)12-18(25-20)13-5-8-23-9-6-13/h3-5,7,10-12,23H,6,8-9H2,1-2H3,(H,22,26)(H,24,25) JCCRIHYBBZRMHV-UHFFFAOYSA-N 353497 3-methoxy-N-methyl-4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzamide::US9796708, Example 729 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353497&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420800 386047236 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696866 CNC(=O)c1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24N4O4S/c1-23-22(27)15-4-5-17(20(12-15)30-2)16-6-9-24-21-18(16)13-19(25-21)14-7-10-26(11-8-14)31(3,28)29/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,23,27)(H,24,25) JJJVQXPBWQYCOF-UHFFFAOYSA-N 353498 3-methoxy-N-methyl-4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 730 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353498&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419966 386047237 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696867 CNC(=O)c1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353499 4-{2-[1-(2,3-dihydroxypropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-3-methoxy-N-methylbenzamide::US9796708, Example 731 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353499&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419693 386047238 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696868 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(N)c(=O)c1=O InChI=1S/C23H19FN4O3/c1-31-18-3-2-13(24)10-15(18)14-4-7-26-23-16(14)11-17(27-23)12-5-8-28(9-6-12)20-19(25)21(29)22(20)30/h2-5,7,10-11H,6,8-9,25H2,1H3,(H,26,27) DAPNMVDJDAIHPP-UHFFFAOYSA-N 353500 3-amino-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclobut-3-ene-1,2-dione::US9796708, Example 732 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353500&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208124 386047239 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696869 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCCC1 InChI=1S/C20H20FN3O/c1-25-19-5-4-14(21)11-16(19)15-7-10-23-20-17(15)12-18(24-20)13-3-2-8-22-9-6-13/h4-7,10-12,22H,2-3,8-9H2,1H3,(H,23,24) ZKUVXNXKFKPYAM-UHFFFAOYSA-N 353501 4-(5-fluoro-2-methoxyphenyl)-2-(2,5,6,7-tetrahydro-14-(5-fluoro-2-methoxyphenyl)-2-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-1H-pyrrolo[2,3-b]pyridine ::US9796708, Example 733::US9796708, Example 832 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353501&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419498 386047240 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696870 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-28-20-6-5-15(22)12-17(20)16-7-9-23-21-18(16)13-19(24-21)14-4-3-10-25(11-8-14)29(2,26)27/h5-9,12-13H,3-4,10-11H2,1-2H3,(H,23,24) LKAYGTOBWZAYBI-UHFFFAOYSA-N 353502 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 734::US9796708, Example 833 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353502&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419687 386047241 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696871 CNC(=O)N1CCCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O2/c1-24-22(28)27-10-3-4-14(8-11-27)19-13-18-16(7-9-25-21(18)26-19)17-12-15(23)5-6-20(17)29-2/h5-9,12-13H,3-4,10-11H2,1-2H3,(H,24,28)(H,25,26) WMBSHDVUXSXJJV-UHFFFAOYSA-N 353503 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-2,3,4,7-tetrahydro-1H-azepine-1-carboxamide::US9796708, Example 735::US9796708, Example 834 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353503&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420066 386047242 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696872 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCS(=O)(=O)C2)CC1 InChI=1S/C24H25FN4O4S/c1-33-22-3-2-17(25)12-19(22)18-4-7-26-24-20(18)13-21(27-24)16-5-8-28(9-6-16)14-23(30)29-10-11-34(31,32)15-29/h2-5,7,12-13H,6,8-11,14-15H2,1H3,(H,26,27) OMEYWRDKBWYMKX-UHFFFAOYSA-N 353504 1-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 736::US9796708, Example 835 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353504&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897249 386047243 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696873 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NS(C)(=O)=O)CC1 InChI=1S/C22H23FN4O4S/c1-31-20-4-3-15(23)11-17(20)16-5-8-24-22-18(16)12-19(25-22)14-6-9-27(10-7-14)13-21(28)26-32(2,29)30/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,24,25)(H,26,28) ZPEPCGBWGHAMFR-UHFFFAOYSA-N 353505 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(methylsulfonyl)acetamide::US9796708, Example 737 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353505&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897306 386047244 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696874 COc1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H28N4O3/c1-27(2)23(29)15-28-11-8-16(9-12-28)21-14-20-18(7-10-25-24(20)26-21)19-6-5-17(30-3)13-22(19)31-4/h5-8,10,13-14H,9,11-12,15H2,1-4H3,(H,25,26) HLGYTJGVHOACKZ-UHFFFAOYSA-N 353506 2-{4-[4-(2,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 738 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353506&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420248 386047245 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696875 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H26N4O2/c1-26(2)22(28)15-27-12-9-16(10-13-27)20-14-19-17(8-11-24-23(19)25-20)18-6-4-5-7-21(18)29-3/h4-9,11,14H,10,12-13,15H2,1-3H3,(H,24,25) UUVYCZHCYOJKJN-UHFFFAOYSA-N 353507 2-{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 739 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353507&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421244 386047246 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696876 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H25FN4O2/c1-27(2)22(29)14-28-10-7-15(8-11-28)20-13-19-17(6-9-25-23(19)26-20)18-5-4-16(24)12-21(18)30-3/h4-7,9,12-13H,8,10-11,14H2,1-3H3,(H,25,26) YWBFHBBSBWIJMX-UHFFFAOYSA-N 353508 2-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 740 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353508&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897239 386047247 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696877 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H24F2N4O2/c1-28(2)22(30)13-29-8-5-14(6-9-29)20-11-17-15(4-7-26-23(17)27-20)16-10-18(24)19(25)12-21(16)31-3/h4-5,7,10-12H,6,8-9,13H2,1-3H3,(H,26,27) HKJMQUMMJVFCES-UHFFFAOYSA-N 353509 2-{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 741 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353509&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419948 386047248 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696878 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)OC(C)(C)C)C1 InChI=1S/C25H28FN3O3/c1-25(2,3)32-23(30)15-29-11-5-6-16(14-29)21-13-20-18(9-10-27-24(20)28-21)19-12-17(26)7-8-22(19)31-4/h6-10,12-13H,5,11,14-15H2,1-4H3,(H,27,28) BGPCWDKEGKRWFQ-UHFFFAOYSA-N 353510 US9796708, Example 742::tert-butyl {5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353510&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208125 386047249 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696879 COc1ccc(F)cc1-c1ccnc2[nH]c(c(Cl)c12)C1=CCN(CC1)S(=O)(=O)NC(C)=O InChI=1S/C21H20ClFN4O4S/c1-12(28)26-32(29,30)27-9-6-13(7-10-27)20-19(22)18-15(5-8-24-21(18)25-20)16-11-14(23)3-4-17(16)31-2/h3-6,8,11H,7,9-10H2,1-2H3,(H,24,25)(H,26,28) LMRRHLJJTWNUFU-UHFFFAOYSA-N 353511 N-({4-[3-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)acetamide::US9796708, Example 743 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353511&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421131 386047250 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696880 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)C(C)(C)C InChI=1S/C24H27FN4O4S/c1-24(2,3)23(30)28-34(31,32)29-11-8-15(9-12-29)20-14-19-17(7-10-26-22(19)27-20)18-13-16(25)5-6-21(18)33-4/h5-8,10,13-14H,9,11-12H2,1-4H3,(H,26,27)(H,28,30) SUONRUOZFVUVTQ-UHFFFAOYSA-N 353512 N-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)-2,2-dimethylpropanamide::US9796708, Example 744 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353512&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420507 386047251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696881 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)N(C)C)C1 InChI=1S/C23H25FN4O2/c1-27(2)22(29)14-28-10-4-5-15(13-28)20-12-19-17(8-9-25-23(19)26-20)18-11-16(24)6-7-21(18)30-3/h5-9,11-12H,4,10,13-14H2,1-3H3,(H,25,26) LRLIRZZSLURXSM-UHFFFAOYSA-N 353513 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 745 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353513&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897337 386047252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696882 COc1ccc(F)cc1-c1ccnc2[nH]c(c(Cl)c12)C1=CCN(CC1)S(=O)(=O)NC(=O)C(C)(C)C InChI=1S/C24H26ClFN4O4S/c1-24(2,3)23(31)29-35(32,33)30-11-8-14(9-12-30)21-20(25)19-16(7-10-27-22(19)28-21)17-13-15(26)5-6-18(17)34-4/h5-8,10,13H,9,11-12H2,1-4H3,(H,27,28)(H,29,31) NJXCGNBURVILJO-UHFFFAOYSA-N 353514 N-({4-[3-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)-2,2-dimethylpropanamide::US9796708, Example 746 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353514&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419682 386047253 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696883 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1C InChI=1S/C23H25FN4O5S/c1-4-33-23(29)27-34(30,31)28-11-8-15(9-12-28)21-14(2)20-17(7-10-25-22(20)26-21)18-13-16(24)5-6-19(18)32-3/h5-8,10,13H,4,9,11-12H2,1-3H3,(H,25,26)(H,27,29) UVALGWCFLAQJAO-UHFFFAOYSA-N 353515 US9796708, Example 747::ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208126 386047254 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696884 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(O)=O)C1 InChI=1S/C21H20FN3O3/c1-28-19-5-4-14(22)9-16(19)15-6-7-23-21-17(15)10-18(24-21)13-3-2-8-25(11-13)12-20(26)27/h3-7,9-10H,2,8,11-12H2,1H3,(H,23,24)(H,26,27) AATREEQPCPCDIG-UHFFFAOYSA-N 353516 US9796708, Example 748::{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353516&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897410 386047255 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696885 CCOC(=O)C1(O)CCN(CC1)C(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C28H31FN4O5/c1-3-38-26(34)28(36)9-14-33(15-10-28)27(35)32-12-7-18(8-13-32)23-17-22-20(6-11-30-25(22)31-23)21-16-19(29)4-5-24(21)37-2/h4-7,11,16-17,36H,3,8-10,12-15H2,1-2H3,(H,30,31) YLUHFIBLWZPEKX-UHFFFAOYSA-N 353517 US9796708, Example 749::ethyl 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)-4-hydroxypiperidine-4-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353517&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420092 386047256 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696886 CNC(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1C InChI=1S/C22H23FN4O2/c1-13-19-16(17-12-15(23)4-5-18(17)29-3)6-9-25-21(19)26-20(13)14-7-10-27(11-8-14)22(28)24-2/h4-7,9,12H,8,10-11H2,1-3H3,(H,24,28)(H,25,26) DLVKVTNLYGOYPK-UHFFFAOYSA-N 353518 4-[4-(5-fluoro-2-methoxyphenyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 750 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420365 386047257 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696887 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C)c12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-13-19-16(17-12-15(22)4-5-18(17)28-2)6-9-23-21(19)24-20(13)14-7-10-25(11-8-14)29(3,26)27/h4-7,9,12H,8,10-11H2,1-3H3,(H,23,24) RLNVFAPZVCCGDH-UHFFFAOYSA-N 353519 4-(5-fluoro-2-methoxyphenyl)-3-methyl-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 751 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420934 386047258 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696888 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CN(C)C InChI=1S/C23H25FN4O2/c1-27(2)14-22(29)28-10-7-15(8-11-28)20-13-19-17(6-9-25-23(19)26-20)18-12-16(24)4-5-21(18)30-3/h4-7,9,12-13H,8,10-11,14H2,1-3H3,(H,25,26) KAKPCBMOKKVMLW-UHFFFAOYSA-N 353520 2-(dimethylamino)-1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 752 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897394 386047259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696889 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C21H19F2N3O3/c1-29-18-3-2-13(22)8-14(18)20-15-9-17(25-21(15)24-10-16(20)23)12-4-6-26(7-5-12)11-19(27)28/h2-4,8-10H,5-7,11H2,1H3,(H,24,25)(H,27,28) KFVWPRIIRDPQBS-UHFFFAOYSA-N 353521 US9796708, Example 753::{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412424 386047260 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696890 CCC(NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)C(O)=O 353522 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}amino)butanoic acid::US9796708, Example 754 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353522&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421383 386047261 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696891 CS(=O)(=O)N1CCC=C(C1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C19H17F2N3O2S/c1-27(25,26)24-9-3-4-12(11-24)17-10-15-13(7-8-22-19(15)23-17)14-5-2-6-16(20)18(14)21/h2,4-8,10H,3,9,11H2,1H3,(H,22,23) GASWYMRUGWSVHS-UHFFFAOYSA-N 353523 4-(2,3-difluorophenyl)-2-[1-(methylsulfonyl)-1,2,5,6-tetrahydropyridin-3-yl]-1H-pyrrolo[2,3-b]yridine::US9796708, Example 755 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 540 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353523&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421179 386047262 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696892 CN(C)C(=O)CN1CCC=C(C1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C22H22F2N4O/c1-27(2)20(29)13-28-10-4-5-14(12-28)19-11-17-15(8-9-25-22(17)26-19)16-6-3-7-18(23)21(16)24/h3,5-9,11H,4,10,12-13H2,1-2H3,(H,25,26) FTLCXZKPMUPCSA-UHFFFAOYSA-N 353524 2-{5-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 756 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 290 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353524&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421106 386047263 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696893 OCC(=O)N1CCC=C(C1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C20H17F2N3O2/c21-16-5-1-4-14(19(16)22)13-6-7-23-20-15(13)9-17(24-20)12-3-2-8-25(10-12)18(27)11-26/h1,3-7,9,26H,2,8,10-11H2,(H,23,24) YAUBPWJRZDSCPB-UHFFFAOYSA-N 353525 1-{5-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxyethanone::US9796708, Example 757 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353525&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419573 386047264 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696894 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(CC1)S(C)(=O)=O 353526 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)azepan-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 758 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353526&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420465 386047265 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696895 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)C1 InChI=1S/C20H18FN3O3/c1-27-18-3-2-13(21)8-15(18)14-4-6-22-20-16(14)9-17(23-20)12-5-7-24(10-12)11-19(25)26/h2-6,8-9H,7,10-11H2,1H3,(H,22,23)(H,25,26) UNOHWMBVGLGFCQ-UHFFFAOYSA-N 353527 US9796708, Example 759::{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897325 386047266 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696896 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCS(=O)(=O)N(C)C)CC1 InChI=1S/C23H29FN4O3S/c1-27(2)32(29,30)13-12-28-10-7-16(8-11-28)21-15-20-18(6-9-25-23(20)26-21)19-14-17(24)4-5-22(19)31-3/h4-6,9,14-16H,7-8,10-13H2,1-3H3,(H,25,26) MGEIXEOGJSYQKR-UHFFFAOYSA-N 353528 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N,N-dimethylethanesulfonamide::US9796708, Example 760 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353528&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419992 386047267 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696897 COc1ccc(c(OC)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H23N3O4/c1-28-15-3-4-17(20(11-15)29-2)16-5-8-23-22-18(16)12-19(24-22)14-6-9-25(10-7-14)13-21(26)27/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,23,24)(H,26,27) ZAXJOWGPLJCANH-UHFFFAOYSA-N 353529 US9796708, Example 761::{4-[4-(2,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353529&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897232 386047268 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696898 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C21H21N3O3/c1-27-19-5-3-2-4-16(19)15-6-9-22-21-17(15)12-18(23-21)14-7-10-24(11-8-14)13-20(25)26/h2-7,9,12H,8,10-11,13H2,1H3,(H,22,23)(H,25,26) KTBVLSNSYQFORY-UHFFFAOYSA-N 353530 US9796708, Example 762::{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353530&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897477 386047269 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696899 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C21H19F2N3O3/c1-29-19-10-17(23)16(22)8-14(19)13-2-5-24-21-15(13)9-18(25-21)12-3-6-26(7-4-12)11-20(27)28/h2-3,5,8-10H,4,6-7,11H2,1H3,(H,24,25)(H,27,28) GQRVGVGZTADVIR-UHFFFAOYSA-N 353531 US9796708, Example 763::{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353531&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897313 386047270 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696900 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CN1CCC(O)C1 353532 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-(3-hydroxypyrrolidin-1-yl)ethanone::US9796708, Example 764 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420288 386047271 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696901 COC(=O)Cn1cc(NC(=O)N2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)cn1 InChI=1S/C26H25FN6O4/c1-36-23-4-3-17(27)11-20(23)19-5-8-28-25-21(19)12-22(31-25)16-6-9-32(10-7-16)26(35)30-18-13-29-33(14-18)15-24(34)37-2/h3-6,8,11-14H,7,9-10,15H2,1-2H3,(H,28,31)(H,30,35) NSISJRSDYHTPLR-UHFFFAOYSA-N 353533 US9796708, Example 765::methyl {4-[({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)amino]-1H-pyrazol-1-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208127 386047272 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696902 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)Nc1cnn(CC(O)=O)c1 InChI=1S/C25H23FN6O4/c1-36-22-3-2-16(26)10-19(22)18-4-7-27-24-20(18)11-21(30-24)15-5-8-31(9-6-15)25(35)29-17-12-28-32(13-17)14-23(33)34/h2-5,7,10-13H,6,8-9,14H2,1H3,(H,27,30)(H,29,35)(H,33,34) XOJVFCFJRDSTIM-UHFFFAOYSA-N 353534 US9796708, Example 766::{4-[({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)amino]-1H-pyrazol-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353534&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897375 386047273 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696903 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NS(=O)(=O)C1CC1 353535 N-(cyclopropylsulfonyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 767 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353535&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420612 386047274 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696904 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C26H23FN4O4S/c1-35-24-8-7-18(27)15-21(24)20-9-12-28-25-22(20)16-23(29-25)17-10-13-31(14-11-17)26(32)30-36(33,34)19-5-3-2-4-6-19/h2-10,12,15-16H,11,13-14H2,1H3,(H,28,29)(H,30,32) QARYSJJDKYYGQB-UHFFFAOYSA-N 353536 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(phenylsulfonyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 768 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353536&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421421 386047275 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696905 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)c1n[nH]c(=O)o1 353537 5-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-1,3,4-oxadiazol-2(3H)-one::US9796708, Example 769 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353537&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420189 386047276 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696906 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(O)=O)CC1 InChI=1S/C21H22FN3O3/c1-28-19-3-2-14(22)10-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)12-20(26)27/h2-4,7,10-11,13H,5-6,8-9,12H2,1H3,(H,23,24)(H,26,27) HFEPIQOROAQEFX-UHFFFAOYSA-N 353538 US9796708, Example 770::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353538&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413276 386047277 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696907 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(O)=O)C1 353539 US9796708, Example 771::{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]pyrrolidin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353539&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897206 386047278 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696908 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(NC1)C(O)=O 353540 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid::US9796708, Example 772 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353540&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419889 386047279 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696909 Fc1cccc(c1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC#N InChI=1S/C21H16F2N4O/c22-17-3-1-2-15(20(17)23)14-5-9-25-21-16(14)12-18(26-21)13-6-10-27(11-7-13)19(28)4-8-24/h1-3,5-6,9,12H,4,7,10-11H2,(H,25,26) YISYFBIFONPMEU-UHFFFAOYSA-N 353541 3-{4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-oxopropanenitrile::US9796708, Example 773 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353541&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419508 386047280 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696910 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)C1(O)CC1 InChI=1S/C23H22FN3O3/c1-30-20-3-2-15(24)12-17(20)16-4-9-25-21-18(16)13-19(26-21)14-5-10-27(11-6-14)22(28)23(29)7-8-23/h2-5,9,12-13,29H,6-8,10-11H2,1H3,(H,25,26) FFXJWWWYDIMMFX-UHFFFAOYSA-N 353542 US9796708, Example 774::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(1-hydroxycyclopropyl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897425 386047281 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696911 OCC(O)CN1CCC=C(C1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F 353543 3-{5-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 775 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420511 386047282 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696912 CC(C)(O)C(=O)N1CCC=C(C1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C22H21F2N3O2/c1-22(2,29)21(28)27-10-4-5-13(12-27)18-11-16-14(8-9-25-20(16)26-18)15-6-3-7-17(23)19(15)24/h3,5-9,11,29H,4,10,12H2,1-2H3,(H,25,26) GCFQZEZCSQETBN-UHFFFAOYSA-N 353544 1-{5-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})-2-hydroxy-2-methylpropan-1-one::US9796708, Example 776 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 790 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353544&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421011 386047283 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696913 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C21H20FN3O3/c1-28-19-10-14(22)2-3-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)12-20(26)27/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,23,24)(H,26,27) AXDJSKSKNOBMNG-UHFFFAOYSA-N 353545 US9796708, Example 777::{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353545&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897401 386047284 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696914 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(O)=O 353546 US9796708, Example 778::{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353546&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411375 386047285 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696915 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N1CCC(O)(CC1)C(O)=O InChI=1S/C26H27FN4O5/c1-36-22-3-2-17(27)14-19(22)18-4-9-28-23-20(18)15-21(29-23)16-5-10-30(11-6-16)25(34)31-12-7-26(35,8-13-31)24(32)33/h2-5,9,14-15,35H,6-8,10-13H2,1H3,(H,28,29)(H,32,33) NEZRSZABSVILJY-UHFFFAOYSA-N 353547 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)-4-hydroxypiperidine-4-carboxylic acid::US9796708, Example 779 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353547&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420057 386047286 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696916 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(C1)C(=O)C(C)(C)O InChI=1S/C23H24FN3O3/c1-23(2,29)22(28)27-10-4-5-14(13-27)19-12-18-16(8-9-25-21(18)26-19)17-11-15(24)6-7-20(17)30-3/h5-9,11-12,29H,4,10,13H2,1-3H3,(H,25,26) NWOBHIXCGNJBCZ-UHFFFAOYSA-N 353548 1-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-hydroxy-2-methylpropan-1-one::US9796708, Example 780 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353548&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421292 386047287 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696917 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NS(=O)(=O)C(C)C 353549 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(propan-2-ylsulfonyl)cyclohex-3-ene--carboxamide::US9796708, Example 781 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353549&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420060 386047288 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696918 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CS(N)(=O)=O InChI=1S/C21H21FN4O4S/c1-30-19-3-2-14(22)10-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-26(9-6-13)20(27)12-31(23,28)29/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,24,25)(H2,23,28,29) RNCPRWTUDLWACX-UHFFFAOYSA-N 353550 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethanesulfonamide::US9796708, Example 782 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353550&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420709 386047289 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696919 CNS(=O)(=O)CC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O4S/c1-24-32(29,30)13-21(28)27-9-6-14(7-10-27)19-12-18-16(5-8-25-22(18)26-19)17-11-15(23)3-4-20(17)31-2/h3-6,8,11-12,24H,7,9-10,13H2,1-2H3,(H,25,26) JTJUJUZHLRKEAG-UHFFFAOYSA-N 353551 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-methyl-2-oxoethanesulfonamide::US9796708, Example 783 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353551&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420604 386047290 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696920 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)OC(C)(C)C)CC1 InChI=1S/C25H28FN3O3/c1-25(2,3)32-23(30)15-29-11-8-16(9-12-29)21-14-20-18(7-10-27-24(20)28-21)19-13-17(26)5-6-22(19)31-4/h5-8,10,13-14H,9,11-12,15H2,1-4H3,(H,27,28) UFLCMSVQPCZLPA-UHFFFAOYSA-N 167872 US9073922, 369::US9796708, Example 784 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167872&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412116 312321716 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696921 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)Nc1cnn(C[C@@H](C)O)c1 InChI=1S/C26H27FN6O3/c1-16(34)14-33-15-19(13-29-33)30-26(35)32-9-6-17(7-10-32)23-12-22-20(5-8-28-25(22)31-23)21-11-18(27)3-4-24(21)36-2/h3-6,8,11-13,15-16,34H,7,9-10,14H2,1-2H3,(H,28,31)(H,30,35)/t16-/m1/s1 RQXNKSZAEUBICO-MRXNPFEDSA-N 353553 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{1-[(2R)-2-hydroxypropyl]-1H-pyrazol-4-yl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 785 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420660 386047292 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696922 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2nn[nH]n2)CC1 InChI=1S/C21H20FN7O/c1-30-19-3-2-14(22)10-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-29(9-6-13)12-20-25-27-28-26-20/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,23,24)(H,25,26,27,28) UYVBDGCYWGBSLU-UHFFFAOYSA-N 353554 4-(5-fluoro-2-methoxyphenyl)-2-[1-(2H-tetrazol-5-ylmethyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 786 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353554&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420712 386047293 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696923 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CC2(CNC2)C1 InChI=1S/C20H20FN3O2/c1-26-16-3-2-12(21)6-14(16)13-4-5-23-18-15(13)7-17(24-18)20(25)8-19(9-20)10-22-11-19/h2-7,22,25H,8-11H2,1H3,(H,23,24) IHFGWHNPKFHXOL-UHFFFAOYSA-N 353555 6-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-azaspiro[3.3]heptan-6-ol::US9796708, Example 787 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353555&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420044 386047294 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696924 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](CO)NC1 InChI=1S/C19H18FN3O2/c1-25-18-3-2-12(20)7-15(18)14-4-5-21-19-16(14)8-17(23-19)11-6-13(10-24)22-9-11/h2-8,13,22,24H,9-10H2,1H3,(H,21,23)/t13-/m1/s1 RANYXLZNYZCFAZ-CYBMUJFWSA-N 353556 US9796708, Example 788::{(2R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419518 386047295 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696925 OC(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C20H17F2N3O2/c21-16-3-1-2-14(19(16)22)13-4-7-23-20-15(13)10-17(24-20)12-5-8-25(9-6-12)11-18(26)27/h1-5,7,10H,6,8-9,11H2,(H,23,24)(H,26,27) SOJWSCLDFZIGST-UHFFFAOYSA-N 353557 US9796708, Example 789::{4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353557&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897364 386047296 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696926 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(O)CC1 353558 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-ol::US9796708, Example 790 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419935 386047297 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696927 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)C1 353559 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]pyrrolidin-1-yl}-N,N-dimethylacetamide::US9796708, Example 791 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420394 386047298 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696928 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(N)C1 353560 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclopent-3-en-1-amine::US9796708, Example 792 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897197 386047299 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696929 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(N)CC1 353561 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclopent-2-en-1-amine::US9796708, Example 793 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897366 386047300 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696930 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CCN1C(=O)c2ccccc2C1=O InChI=1S/C29H25FN4O5S/c1-39-26-7-6-19(30)16-23(26)20-8-11-31-27-24(20)17-25(32-27)18-9-12-33(13-10-18)40(37,38)15-14-34-28(35)21-4-2-3-5-22(21)29(34)36/h2-9,11,16-17H,10,12-15H2,1H3,(H,31,32) OBCJRTIQQGVCPF-UHFFFAOYSA-N 353562 2-[2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)ethyl]-1H-isoindole-1,3(2H)-dione::US9796708, Example 794 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897228 386047301 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696931 CCOc1c(NCCOc2ccc(F)cc2-c2ccnc3[nH]c(cc23)C2=CCN(CC2)c2c(OCC)c(=O)c2=O)c(=O)c1=O InChI=1S/C32H29FN4O7/c1-3-42-30-24(26(38)28(30)40)34-11-14-44-23-6-5-18(33)15-20(23)19-7-10-35-32-21(19)16-22(36-32)17-8-12-37(13-9-17)25-27(39)29(41)31(25)43-4-2/h5-8,10,15-16,34H,3-4,9,11-14H2,1-2H3,(H,35,36) KFAQOHYLCZKDQU-UHFFFAOYSA-N 353563 3-ethoxy-4-{4-[4-(2-{2-[(2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino]ethoxy}-5-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobut-3-ene-1,2-dione::US9796708, Example 795 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353563&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208128 386047302 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696932 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN[C@H]1CCCC[C@@H]1O InChI=1S/C28H34FN5O3/c1-37-26-7-6-19(29)16-21(26)20-8-11-31-27-22(20)17-24(33-27)18-9-14-34(15-10-18)28(36)32-13-12-30-23-4-2-3-5-25(23)35/h6-9,11,16-17,23,25,30,35H,2-5,10,12-15H2,1H3,(H,31,33)(H,32,36)/t23-,25-/m0/s1 NDEWTUAUFLENLL-ZCYQVOJMSA-N 353564 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(2-{[(1S,2S)-2-hydroxycyclohexyl]amino}ethyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 796 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353564&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897466 386047303 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696933 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCCN(C)C InChI=1S/C26H33FN6O2/c1-32(2)15-12-28-10-11-30-26(34)33-13-7-18(8-14-33)23-17-22-20(6-9-29-25(22)31-23)21-16-19(27)4-5-24(21)35-3/h4-7,9,16-17,28H,8,10-15H2,1-3H3,(H,29,31)(H,30,34) ITDNROQIQNRYRV-UHFFFAOYSA-N 353565 N-(2-{[2-(dimethylamino)ethyl]amino}ethyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 797 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353565&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420120 386047304 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696934 COCCN(C)CCNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C26H32FN5O3/c1-31(14-15-34-2)13-10-29-26(33)32-11-7-18(8-12-32)23-17-22-20(6-9-28-25(22)30-23)21-16-19(27)4-5-24(21)35-3/h4-7,9,16-17H,8,10-15H2,1-3H3,(H,28,30)(H,29,33) ZYWHXBHIGBLJHQ-UHFFFAOYSA-N 353566 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(2-methoxyethyl)(methyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 798 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353566&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421344 386047305 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696935 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCN(CC1)C(=O)c1ccc(C)cc1 InChI=1S/C34H37FN6O3/c1-23-3-5-25(6-4-23)33(42)40-19-17-39(18-20-40)16-13-37-34(43)41-14-10-24(11-15-41)30-22-29-27(9-12-36-32(29)38-30)28-21-26(35)7-8-31(28)44-2/h3-10,12,21-22H,11,13-20H2,1-2H3,(H,36,38)(H,37,43) MSMWAZSHKDVKTL-UHFFFAOYSA-N 353567 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[4-(4-methylbenzoyl)piperazin-1-yl]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 799 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353567&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420993 386047306 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696936 CS(=O)(=O)N1CCN(CCNC(=O)N2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2O)CC1 InChI=1S/C26H31FN6O4S/c1-38(36,37)33-14-12-31(13-15-33)11-8-29-26(35)32-9-5-18(6-10-32)23-17-22-20(4-7-28-25(22)30-23)21-16-19(27)2-3-24(21)34/h2-5,7,16-17,34H,6,8-15H2,1H3,(H,28,30)(H,29,35) JJCVXMOJCVQUQD-UHFFFAOYSA-N 353568 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[4-(methylsulfonyl)piperazin-1-yl]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 800 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353568&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208129 386047307 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696937 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCCO InChI=1S/C24H28FN5O3/c1-33-22-3-2-17(25)14-19(22)18-4-7-27-23-20(18)15-21(29-23)16-5-11-30(12-6-16)24(32)28-9-8-26-10-13-31/h2-5,7,14-15,26,31H,6,8-13H2,1H3,(H,27,29)(H,28,32) CSJXGUHPAJOPAW-UHFFFAOYSA-N 353569 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(2-hydroxyethyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 801::US9796708, Example 900 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419871 386047308 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696938 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCc1cccc(c1)C(F)(F)F InChI=1S/C30H29F4N5O2/c1-41-27-6-5-22(31)16-24(27)23-7-10-36-28-25(23)17-26(38-28)20-8-13-39(14-9-20)29(40)37-12-11-35-18-19-3-2-4-21(15-19)30(32,33)34/h2-8,10,15-17,35H,9,11-14,18H2,1H3,(H,36,38)(H,37,40) KQKRNCWYCGHHSU-UHFFFAOYSA-N 353570 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(2-{[3-(trifluoromethyl)benzyl]amino}ethyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 802 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897471 386047309 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696939 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C21H20F2N4O4S/c1-2-31-21(28)26-32(29,30)27-10-7-13(8-11-27)18-12-16-14(6-9-24-20(16)25-18)15-4-3-5-17(22)19(15)23/h3-7,9,12H,2,8,10-11H2,1H3,(H,24,25)(H,26,28) UIBOSKZCNMNMTK-UHFFFAOYSA-N 353571 US9796708, Example 803::ethyl ({4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208130 386047310 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696138 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167517 US9073922, 1::US9796708, Example 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167517&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412455 312321362 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696139 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167518 US9073922, 2::US9796708, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413723 312321363 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696140 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CCCNC1 InChI=1S/C19H20FN3O/c1-24-18-5-4-13(20)9-15(18)14-6-8-22-19-16(14)10-17(23-19)12-3-2-7-21-11-12/h4-6,8-10,12,21H,2-3,7,11H2,1H3,(H,22,23)/t12-/m0/s1 JCWDLMMDEICJNN-LBPRGKRZSA-N 167519 US9073922, 3::US9796708, Example 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413878 312321364 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696141 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@@H]1CCCNC1 InChI=1S/C19H20FN3O/c1-24-18-5-4-13(20)9-15(18)14-6-8-22-19-16(14)10-17(23-19)12-3-2-7-21-11-12/h4-6,8-10,12,21H,2-3,7,11H2,1H3,(H,22,23)/t12-/m1/s1 JCWDLMMDEICJNN-GFCCVEGCSA-N 167520 US9073922, 4::US9796708, Example 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412409 312321365 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696142 COc1ccc(N)nc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167521 US9073922, 5::US9796708, Example 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86293960 312321366 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696940 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC(F)(F)F InChI=1S/C22H20F4N4O5S/c1-34-19-3-2-14(23)10-16(19)15-4-7-27-20-17(15)11-18(28-20)13-5-8-30(9-6-13)36(32,33)29-21(31)35-12-22(24,25)26/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,27,28)(H,29,31) LGGXQHHUXXXRHX-UHFFFAOYSA-N 353572 2,2,2-trifluoroethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 804 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419797 386047311 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696941 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(=O)CC1 InChI=1S/C20H17FN2O2/c1-25-19-7-4-13(21)10-16(19)15-8-9-22-20-17(15)11-18(23-20)12-2-5-14(24)6-3-12/h2,4,7-11H,3,5-6H2,1H3,(H,22,23) JNOFCFHRZORGGO-UHFFFAOYSA-N 353573 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-one::US9796708, Example 805 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413654 386047312 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696942 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCSCC1 InChI=1S/C19H17FN2OS/c1-23-18-3-2-13(20)10-15(18)14-4-7-21-19-16(14)11-17(22-19)12-5-8-24-9-6-12/h2-5,7,10-11H,6,8-9H2,1H3,(H,21,22) KNERBXHDDPGXTO-UHFFFAOYSA-N 353574 2-(3,6-dihydro-2H-thiopyran-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 806 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353574&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420263 386047313 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696943 CNC(=O)c1ccc(c(F)c1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H19FN4O/c1-22-20(26)13-2-3-15(17(21)10-13)14-6-9-24-19-16(14)11-18(25-19)12-4-7-23-8-5-12/h2-4,6,9-11,23H,5,7-8H2,1H3,(H,22,26)(H,24,25) WDBFOQGCXMAAMO-UHFFFAOYSA-N 353575 3-fluoro-N-methyl-4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzamide::US9796708, Example 807 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353575&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419843 386047314 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696944 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N[C@@H](C)C(O)=O InChI=1S/C23H23FN4O4/c1-13(22(29)30)26-23(31)28-9-6-14(7-10-28)19-12-18-16(5-8-25-21(18)27-19)17-11-15(24)3-4-20(17)32-2/h3-6,8,11-13H,7,9-10H2,1-2H3,(H,25,27)(H,26,31)(H,29,30)/t13-/m0/s1 WFJRKKIMTJCTFG-ZDUSSCGKSA-N 353576 N-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)alanine::US9796708, Example 808 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353576&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420328 386047315 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696945 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCS(=O)CC1 353577 4-(5-fluoro-2-methoxyphenyl)-2-(1-oxido-3,6-dihydro-2H-thiopyran-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 809 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420823 386047316 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696946 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NS(=O)(=O)C1(C)CC1 353578 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[(1-methylcyclopropyl)sulfonyl]cyclohex-3-ene-1-carboxamide::US9796708, Example 810 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419620 386047317 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696947 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NS(=O)(=O)CC(C)C 353579 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[(2-methylpropyl)sulfonyl]cyclohex-3-ene-1-carboxamide::US9796708, Example 811 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419722 386047318 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696948 Fc1cccc(c1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C25H20F2N4O3S/c26-21-8-4-7-19(23(21)27)18-9-12-28-24-20(18)15-22(29-24)16-10-13-31(14-11-16)25(32)30-35(33,34)17-5-2-1-3-6-17/h1-10,12,15H,11,13-14H2,(H,28,29)(H,30,32) MMNRYJUHZVPKSL-UHFFFAOYSA-N 353580 4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(phenylsulfonyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 812 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897309 386047319 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696949 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCNCC1)C(N)=O InChI=1S/C20H19FN4O2/c1-27-17-3-2-12(21)8-13(17)18-14-9-16(11-4-6-23-7-5-11)25-20(14)24-10-15(18)19(22)26/h2-4,8-10,23H,5-7H2,1H3,(H2,22,26)(H,24,25) HNLPJWPRSLPSHW-UHFFFAOYSA-N 353581 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide::US9796708, Example 813 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353581&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421006 386047320 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696950 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1)C#N 353582 2-[1-(2,3-dihydroxypropyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 814 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420695 386047321 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696951 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H24ClFN4O2/c1-28(2)21(30)13-29-8-6-14(7-9-29)19-11-17-22(18(24)12-26-23(17)27-19)16-10-15(25)4-5-20(16)31-3/h4-6,10-12H,7-9,13H2,1-3H3,(H,26,27) XJWKIWOBXAHWMY-UHFFFAOYSA-N 353583 2-{4-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 815 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353583&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897367 386047322 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696952 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C21H19ClFN3O3/c1-29-18-3-2-13(23)8-14(18)20-15-9-17(25-21(15)24-10-16(20)22)12-4-6-26(7-5-12)11-19(27)28/h2-4,8-10H,5-7,11H2,1H3,(H,24,25)(H,27,28) BAIFTTTZEGPPSS-UHFFFAOYSA-N 353584 US9796708, Example 816::{4-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897360 386047323 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696953 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353585 3-{4-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 817 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897205 386047324 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696954 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@@H]1C[C@H](O)CN1 InChI=1S/C24H25FN4O3/c1-32-22-3-2-15(25)10-18(22)17-4-7-26-23-19(17)12-20(28-23)14-5-8-29(9-6-14)24(31)21-11-16(30)13-27-21/h2-5,7,10,12,16,21,27,30H,6,8-9,11,13H2,1H3,(H,26,28)/t16-,21-/m0/s1 AWSPBNDPIYXQST-KKSFZXQISA-N 353586 US9796708, Example 818::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}[(2S,4S)-4-hydroxypyrrolidin-2-yl]methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353586&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897436 386047325 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696955 CCNCCNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C24H28FN5O2/c1-3-26-10-11-28-24(31)30-12-7-16(8-13-30)21-15-20-18(6-9-27-23(20)29-21)19-14-17(25)4-5-22(19)32-2/h4-7,9,14-15,26H,3,8,10-13H2,1-2H3,(H,27,29)(H,28,31) YKYNEHRPYFBYIK-UHFFFAOYSA-N 353587 N-[2-(ethylamino)ethyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 819 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419698 386047326 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696956 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNC1CC1 InChI=1S/C25H28FN5O2/c1-33-23-5-2-17(26)14-20(23)19-6-9-28-24-21(19)15-22(30-24)16-7-12-31(13-8-16)25(32)29-11-10-27-18-3-4-18/h2,5-7,9,14-15,18,27H,3-4,8,10-13H2,1H3,(H,28,30)(H,29,32) ISQXMZTXMKWYBL-UHFFFAOYSA-N 353588 N-[2-(cyclopropylamino)ethyl]-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 820 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420174 386047327 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696957 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCc1ccccn1 InChI=1S/C28H29FN6O2/c1-37-26-6-5-20(29)16-23(26)22-7-11-32-27-24(22)17-25(34-27)19-8-14-35(15-9-19)28(36)33-13-12-30-18-21-4-2-3-10-31-21/h2-8,10-11,16-17,30H,9,12-15,18H2,1H3,(H,32,34)(H,33,36) AGQIKFMGCDBXJM-UHFFFAOYSA-N 353589 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(pyridin-2-ylmethyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 821 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897426 386047328 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696958 Nc1c(NCCOc2ccc(F)cc2-c2ccnc3[nH]c(cc23)C2=CCN(CC2)c2c(N)c(=O)c2=O)c(=O)c1=O InChI=1S/C28H23FN6O5/c29-14-1-2-19(40-10-7-32-22-20(30)24(36)26(22)38)16(11-14)15-3-6-33-28-17(15)12-18(34-28)13-4-8-35(9-5-13)23-21(31)25(37)27(23)39/h1-4,6,11-12,32H,5,7-10,30-31H2,(H,33,34) HECJHZLWXDYWRN-UHFFFAOYSA-N 353590 3-amino-4-{4-[4-(2-{2-[(2-amino-3,4-dioxocyclobut-1-en-1-yl)amino]ethoxy}-5-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobut-3-ene-1,2-dione::US9796708, Example 822 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 540 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353590&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208131 386047329 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696959 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C29H35FN4O5S/c1-29(2,3)39-28(35)33-13-10-21(11-14-33)40(36,37)34-15-8-19(9-16-34)25-18-24-22(7-12-31-27(24)32-25)23-17-20(30)5-6-26(23)38-4/h5-8,12,17-18,21H,9-11,13-16H2,1-4H3,(H,31,32) OFECGWYDDAJCAU-UHFFFAOYSA-N 353591 US9796708, Example 823::tert-butyl 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)piperidine-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1950 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897201 386047330 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696960 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(N(C1)S(C)(=O)=O)C(O)=O 353592 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(methylsulfonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid::US9796708, Example 824 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353592&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421157 386047331 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696961 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CCNCC1 InChI=1S/C24H27FN4O3S/c1-32-23-3-2-17(25)14-20(23)19-6-11-27-24-21(19)15-22(28-24)16-7-12-29(13-8-16)33(30,31)18-4-9-26-10-5-18/h2-3,6-7,11,14-15,18,26H,4-5,8-10,12-13H2,1H3,(H,27,28) MJCDQVLKUSMFGC-UHFFFAOYSA-N 353593 4-(5-fluoro-2-methoxyphenyl)-2-[1-(piperidin-4-ylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 825 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353593&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419717 386047332 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696962 CN(C)C(=O)c1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24N4O3S/c1-25(2)22(27)17-6-4-15(5-7-17)18-8-11-23-21-19(18)14-20(24-21)16-9-12-26(13-10-16)30(3,28)29/h4-9,11,14H,10,12-13H2,1-3H3,(H,23,24) UAPQEECPNCKWOK-UHFFFAOYSA-N 353594 N,N-dimethyl-4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 826 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353594&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420062 386047333 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696963 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(C)C(=O)N(C)C 353595 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylpropanamide::US9796708, Example 827 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353595&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421141 386047334 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696964 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2S(C)(=O)=O 353596 4-(4-fluoro-2-methoxyphenyl)-2-[8-(methylsulfonyl)-8-azabicyclo[3.2.1]oct-2-en-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 828 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353596&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421070 386047335 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696965 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2S(C)(=O)=O 353597 4-(4,5-difluoro-2-methoxyphenyl)-2-[8-(methylsulfonyl)-8-azabicyclo[3.2.1]oct-2-en-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 829 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420445 386047336 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696966 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2S(C)(=O)=O 353598 4-(2-methoxyphenyl)-2-[8-(methylsulfonyl)-8-azabicyclo[3.2.1]oct-2-en-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 830 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420617 386047337 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696967 COc1c(F)cccc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H18FN3O/c1-24-18-14(3-2-4-16(18)20)13-7-10-22-19-15(13)11-17(23-19)12-5-8-21-9-6-12/h2-5,7,10-11,21H,6,8-9H2,1H3,(H,22,23) HKWHSPOWJRMGNZ-UHFFFAOYSA-N 353599 4-(3-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 831 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353599&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420003 386047338 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696968 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCCC1 InChI=1S/C20H20FN3O/c1-25-19-5-4-14(21)11-16(19)15-7-10-23-20-17(15)12-18(24-20)13-3-2-8-22-9-6-13/h4-7,10-12,22H,2-3,8-9H2,1H3,(H,23,24) ZKUVXNXKFKPYAM-UHFFFAOYSA-N 353501 4-(5-fluoro-2-methoxyphenyl)-2-(2,5,6,7-tetrahydro-14-(5-fluoro-2-methoxyphenyl)-2-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-1H-pyrrolo[2,3-b]pyridine ::US9796708, Example 733::US9796708, Example 832 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353501&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419498 386047240 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696969 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-28-20-6-5-15(22)12-17(20)16-7-9-23-21-18(16)13-19(24-21)14-4-3-10-25(11-8-14)29(2,26)27/h5-9,12-13H,3-4,10-11H2,1-2H3,(H,23,24) LKAYGTOBWZAYBI-UHFFFAOYSA-N 353502 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 734::US9796708, Example 833 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353502&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419687 386047241 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696970 CNC(=O)N1CCCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O2/c1-24-22(28)27-10-3-4-14(8-11-27)19-13-18-16(7-9-25-21(18)26-19)17-12-15(23)5-6-20(17)29-2/h5-9,12-13H,3-4,10-11H2,1-2H3,(H,24,28)(H,25,26) WMBSHDVUXSXJJV-UHFFFAOYSA-N 353503 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-2,3,4,7-tetrahydro-1H-azepine-1-carboxamide::US9796708, Example 735::US9796708, Example 834 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353503&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420066 386047242 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696971 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCS(=O)(=O)C2)CC1 InChI=1S/C24H25FN4O4S/c1-33-22-3-2-17(25)12-19(22)18-4-7-26-24-20(18)13-21(27-24)16-5-8-28(9-6-16)14-23(30)29-10-11-34(31,32)15-29/h2-5,7,12-13H,6,8-11,14-15H2,1H3,(H,26,27) OMEYWRDKBWYMKX-UHFFFAOYSA-N 353504 1-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 736::US9796708, Example 835 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353504&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897249 386047243 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696972 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@@H]1C[C@@H](O)CN1 InChI=1S/C24H25FN4O3/c1-32-22-3-2-15(25)10-18(22)17-4-7-26-23-19(17)12-20(28-23)14-5-8-29(9-6-14)24(31)21-11-16(30)13-27-21/h2-5,7,10,12,16,21,27,30H,6,8-9,11,13H2,1H3,(H,26,28)/t16-,21+/m1/s1 AWSPBNDPIYXQST-IERDGZPVSA-N 353604 US9796708, Example 836::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}[(2S,4R)-4-hydroxypyrrolidin-2-yl]methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353604&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897211 386047339 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696973 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@H]1C[C@H](O)CN1 InChI=1S/C24H25FN4O3/c1-32-22-3-2-15(25)10-18(22)17-4-7-26-23-19(17)12-20(28-23)14-5-8-29(9-6-14)24(31)21-11-16(30)13-27-21/h2-5,7,10,12,16,21,27,30H,6,8-9,11,13H2,1H3,(H,26,28)/t16-,21+/m0/s1 AWSPBNDPIYXQST-HRAATJIYSA-N 353605 US9796708, Example 837::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}[(2R,4S)-4-hydroxypyrrolidin-2-yl]methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353605&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897354 386047340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696974 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)N(C)C 353606 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethylcyclohex-3-ene-1-carboxamide::US9796708, Example 838 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353606&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420253 386047341 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696975 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](C)C(O)=O InChI=1S/C23H24FN3O3/c1-13(23(28)29)26-16-6-3-14(4-7-16)20-12-19-17(9-10-25-22(19)27-20)18-11-15(24)5-8-21(18)30-2/h3,5,8-13,16,26H,4,6-7H2,1-2H3,(H,25,27)(H,28,29)/t13-,16?/m0/s1 YFUWVBYKXSFBRM-KNVGNIICSA-N 353607 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}alanine::US9796708, Example 839 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353607&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897291 386047342 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696976 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CCN InChI=1S/C21H23FN4O3S/c1-29-20-3-2-15(22)12-17(20)16-4-8-24-21-18(16)13-19(25-21)14-5-9-26(10-6-14)30(27,28)11-7-23/h2-5,8,12-13H,6-7,9-11,23H2,1H3,(H,24,25) GZLXUGGGFKYGTR-UHFFFAOYSA-N 353608 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)ethanamine::US9796708, Example 840 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353608&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421079 386047343 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696977 CCCNC(=O)c1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H26N4O3S/c1-3-11-25-23(28)18-6-4-16(5-7-18)19-8-12-24-22-20(19)15-21(26-22)17-9-13-27(14-10-17)31(2,29)30/h4-9,12,15H,3,10-11,13-14H2,1-2H3,(H,24,26)(H,25,28) QGKXEWJBSDIWHY-UHFFFAOYSA-N 353609 4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-propylbenzamide::US9796708, Example 841 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353609&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420084 386047344 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696978 CNC(=O)c1ccc(c(F)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H21FN4O3S/c1-23-21(27)14-3-4-16(18(22)11-14)15-5-8-24-20-17(15)12-19(25-20)13-6-9-26(10-7-13)30(2,28)29/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,27)(H,24,25) QPIGDTWQSKDCBO-UHFFFAOYSA-N 353610 3-fluoro-N-methyl-4-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 842 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353610&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420474 386047345 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696979 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(cc1F)C(=O)NC InChI=1S/C23H24FN5O5S/c1-3-34-23(31)28-35(32,33)29-10-7-14(8-11-29)20-13-18-16(6-9-26-21(18)27-20)17-5-4-15(12-19(17)24)22(30)25-2/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,25,30)(H,26,27)(H,28,31) FSONGVOHYNSFDM-UHFFFAOYSA-N 353611 US9796708, Example 843::ethyl {[4-{4-[2-fluoro-4-(methylcarbamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3,6-dihydropyridin-1(2H)-yl]sulfonyl}carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353611&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208132 386047346 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696980 CNC(=O)c1ccc(c(F)c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H21FN4O3/c1-24-22(30)14-2-3-16(18(23)10-14)15-4-7-25-21-17(15)11-19(26-21)13-5-8-27(9-6-13)12-20(28)29/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,24,30)(H,25,26)(H,28,29) NSRQRPSEULHEOS-UHFFFAOYSA-N 353612 US9796708, Example 844::[4-{4-[2-fluoro-4-(methylcarbamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3,6-dihydropyridin-1(2H)-yl]acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353612&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897333 386047347 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696981 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CNCC2C1 353613 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 845 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353613&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413706 386047348 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696982 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(N(C1)C(=O)OC(C)(C)C)C(=O)N(C)C 353614 US9796708, Example 846::tert-butyl 2-(dimethylcarbamoyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrole-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353614&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419879 386047349 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696983 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(N(C1)C(=O)OC(C)(C)C)C(=O)NS(C)(=O)=O 353615 US9796708, Example 847::tert-butyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-[(methylsulfonyl)carbamoyl]-2,5-dihydro-1H-pyrrole-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353615&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419877 386047350 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696984 CNC(=O)c1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H19FN4O/c1-22-20(26)15-3-2-13(10-17(15)21)14-6-9-24-19-16(14)11-18(25-19)12-4-7-23-8-5-12/h2-4,6,9-11,23H,5,7-8H2,1H3,(H,22,26)(H,24,25) MIIYEUKUEBIWRE-UHFFFAOYSA-N 353616 2-fluoro-N-methyl-4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzamide::US9796708, Example 848 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353616&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420137 386047351 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696985 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(C(=O)NC)c(F)c1 InChI=1S/C22H22FN5O2/c1-24-21(29)16-4-3-14(11-18(16)23)15-5-8-26-20-17(15)12-19(27-20)13-6-9-28(10-7-13)22(30)25-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,24,29)(H,25,30)(H,26,27) OQSDTMQYJVQINX-UHFFFAOYSA-N 353617 4-{4-[3-fluoro-4-(methylcarbamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 849 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353617&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420676 386047352 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696986 CNC(=O)c1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H26FN5O2/c1-26-24(32)18-5-4-16(12-20(18)25)17-6-9-27-23-19(17)13-21(28-23)15-7-10-30(11-8-15)14-22(31)29(2)3/h4-7,9,12-13H,8,10-11,14H2,1-3H3,(H,26,32)(H,27,28) FTEQFQKOJLKNKF-UHFFFAOYSA-N 353618 4-(2-{1-[2-(dimethylamino)-2-oxoethyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-fluoro-N-methylbenzamide::US9796708, Example 850 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353618&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897296 386047353 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696987 CNC(=O)c1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 353619 4-{2-[1-(2,3-dihydroxypropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-2-fluoro-N-methylbenzamide::US9796708, Example 851 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353619&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420206 386047354 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696988 COc1ccc(F)cc1-c1c(OC)cnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O4S/c1-28-18-5-4-14(22)10-15(18)20-16-11-17(24-21(16)23-12-19(20)29-2)13-6-8-25(9-7-13)30(3,26)27/h4-6,10-12H,7-9H2,1-3H3,(H,23,24) JFGMQQRPDJBHTI-UHFFFAOYSA-N 353620 4-(5-fluoro-2-methoxyphenyl)-5-methoxy-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 852 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 620 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353620&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419891 386047355 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696989 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCC(C1)C(O)=O 353621 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 853::US9796708, Example 854 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353621&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420924 386047356 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696990 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCC(C1)C(O)=O 353621 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 853::US9796708, Example 854 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353621&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420924 386047356 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696991 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNC(CO)C1 353623 US9796708, Example 855::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,6-tetrahydropyridin-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353623&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412075 386047357 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696992 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2COCC(C1)N2 353624 7-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-oxa-9-azabicyclo[3.3.1]non-6-ene::US9796708, Example 856 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353624&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421107 386047358 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696143 COc1ccc(cc1-c1ccnc2[nH]c(cc12)C1CCCNC1)C1=NCCN1 167522 US9073922, 6::US9796708, Example 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167522&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412453 312321367 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696144 COc1ccc(cc1-c1ccnc2[nH]c(cc12)C1CCCNC1)C1CC1 167523 US9073922, 7::US9796708, Example 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4700 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167523&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412592 312321368 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696145 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCCN(C)C1 167524 US9073922, 8::US9796708, Example 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167524&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412324 312321369 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696146 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(C)C1 167525 US9073922, 9::US9796708, Example 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167525&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413691 312321370 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696147 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(C1)C(C)=O 167526 US9073922, 10::US9796708, Example 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167526&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412411 312321371 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696148 Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167527 US9073922, 11::US9796708, Example 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294143 312321372 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696149 CN1CCCC(C1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccccc2)ccc1Cl 167528 US9073922, 12::US9796708, Example 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167528&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294144 312321373 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696150 CN1CCCC(C1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2ccccc2)n1 167529 US9073922, 13::US9796708, Example 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167529&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294145 312321374 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696151 COc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167530 US9073922, 14::US9796708, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 490 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167530&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294529 312321375 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696152 CC(C)S(=O)(=O)N1CCCC(C1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccccc2)ccc1Cl 167531 US9073922, 15::US9796708, Example 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1400 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167531&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411597 312321376 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696153 COC(=O)N1CCCC(C1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccccc2)ccc1Cl 167532 US9073922, 16::US9796708, Example 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 770 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86293961 312321377 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696154 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20FN3O/c1-24-18-3-2-13(20)10-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-3,6,9-12,21H,4-5,7-8H2,1H3,(H,22,23) MJRNPYFGLVZCNJ-UHFFFAOYSA-N 167533 US9073922, 17::US9796708, Example 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413908 312321378 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696155 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20FN3O/c1-24-18-10-13(20)2-3-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-3,6,9-12,21H,4-5,7-8H2,1H3,(H,22,23) UBVYPGDWOQOPMK-UHFFFAOYSA-N 167534 US9073922, 18::US9796708, Example 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167534&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412502 312321379 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696156 COc1cc(Cl)ccc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20ClN3O/c1-24-18-10-13(20)2-3-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-3,6,9-12,21H,4-5,7-8H2,1H3,(H,22,23) QJBSSUGSOKGPLE-UHFFFAOYSA-N 167535 US9073922, 19::US9796708, Example 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167535&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411989 312321380 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696157 COc1cccnc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C18H20N4O/c1-23-16-3-2-7-20-17(16)13-6-10-21-18-14(13)11-15(22-18)12-4-8-19-9-5-12/h2-3,6-7,10-12,19H,4-5,8-9H2,1H3,(H,21,22) SDRLTBJZPCHNNR-UHFFFAOYSA-N 167536 US9073922, 20::US9796708, Example 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167536&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294325 312321381 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696158 COc1ccc(N)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C18H21N5O/c1-24-15-2-3-16(19)23-17(15)12-6-9-21-18-13(12)10-14(22-18)11-4-7-20-8-5-11/h2-3,6,9-11,20H,4-5,7-8H2,1H3,(H2,19,23)(H,21,22) DJOFKUMASKWNMV-UHFFFAOYSA-N 167537 US9073922, 21::US9796708, Example 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167537&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294326 312321382 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696159 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H19F2N3O/c1-25-18-10-16(21)15(20)8-13(18)12-4-7-23-19-14(12)9-17(24-19)11-2-5-22-6-3-11/h4,7-11,22H,2-3,5-6H2,1H3,(H,23,24) RSFWRUHWJBVDCK-UHFFFAOYSA-N 167538 US9073922, 22::US9796708, Example 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167538&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414062 312321383 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696160 COc1ccc(Cl)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20ClN3O/c1-24-18-3-2-13(20)10-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-3,6,9-12,21H,4-5,7-8H2,1H3,(H,22,23) GVJWSUOSCNRXJM-UHFFFAOYSA-N 167539 US9073922, 23::US9796708, Example 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167539&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413287 312321384 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696161 COc1ccc(C)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C20H23N3O/c1-13-3-4-19(24-2)16(11-13)15-7-10-22-20-17(15)12-18(23-20)14-5-8-21-9-6-14/h3-4,7,10-12,14,21H,5-6,8-9H2,1-2H3,(H,22,23) ZVWCWZNAOYFMFZ-UHFFFAOYSA-N 167540 US9073922, 24::US9796708, Example 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167540&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411392 312321385 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696162 COc1c(Cl)cccc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20ClN3O/c1-24-18-14(3-2-4-16(18)20)13-7-10-22-19-15(13)11-17(23-19)12-5-8-21-9-6-12/h2-4,7,10-12,21H,5-6,8-9H2,1H3,(H,22,23) QYNOXIYXUPRZQQ-UHFFFAOYSA-N 167541 US9073922, 25::US9796708, Example 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167541&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411930 312321386 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696163 COc1ccc(F)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C18H19FN4O/c1-24-15-2-3-16(19)23-17(15)12-6-9-21-18-13(12)10-14(22-18)11-4-7-20-8-5-11/h2-3,6,9-11,20H,4-5,7-8H2,1H3,(H,21,22) FEZLATBBGWKLAL-UHFFFAOYSA-N 167542 US9073922, 26::US9796708, Example 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294327 312321387 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696164 COc1ccccc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H21N3O/c1-23-18-5-3-2-4-15(18)14-8-11-21-19-16(14)12-17(22-19)13-6-9-20-10-7-13/h2-5,8,11-13,20H,6-7,9-10H2,1H3,(H,21,22) ZBDGSTMYUAPIGW-UHFFFAOYSA-N 167543 US9073922, 27::US9796708, Example 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413103 312321388 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696165 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C20H22FN3O/c1-24-9-6-13(7-10-24)18-12-17-15(5-8-22-20(17)23-18)16-11-14(21)3-4-19(16)25-2/h3-5,8,11-13H,6-7,9-10H2,1-2H3,(H,22,23) RWNAVSXVRGSVMY-UHFFFAOYSA-N 167544 US9073922, 28::US9796708, Example 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167544&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413420 312321389 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696166 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C20H22FN3O/c1-24-9-6-13(7-10-24)18-12-17-15(5-8-22-20(17)23-18)16-4-3-14(21)11-19(16)25-2/h3-5,8,11-13H,6-7,9-10H2,1-2H3,(H,22,23) MYGCBFRVFDUTBD-UHFFFAOYSA-N 167545 US9073922, 29::US9796708, Example 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167545&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412915 312321390 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696167 COc1ccc(C)cc1-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C21H25N3O/c1-14-4-5-20(25-3)17(12-14)16-6-9-22-21-18(16)13-19(23-21)15-7-10-24(2)11-8-15/h4-6,9,12-13,15H,7-8,10-11H2,1-3H3,(H,22,23) IXCNWTDYHJDAGL-UHFFFAOYSA-N 167546 US9073922, 30::US9796708, Example 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167546&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413628 312321391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696168 COc1ccncc1-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C19H22N4O/c1-23-9-5-13(6-10-23)17-11-15-14(3-8-21-19(15)22-17)16-12-20-7-4-18(16)24-2/h3-4,7-8,11-13H,5-6,9-10H2,1-2H3,(H,21,22) MXXIRDLEGYLLKG-UHFFFAOYSA-N 167547 US9073922, 31::US9796708, Example 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167547&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294328 312321392 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696169 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1c(Cl)ccc(N)n1Cc1ccccc1 InChI=1S/C25H26ClN5/c1-30-13-10-18(11-14-30)22-15-20-19(9-12-28-25(20)29-22)24-21(26)7-8-23(27)31(24)16-17-5-3-2-4-6-17/h2-9,12,15,18H,10-11,13-14,16,27H2,1H3/b24-19+ DAOBNIVAQBWVNC-LYBHJNIJSA-N 351738 N-benzyl-5-chloro-6-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]pyridin-2-amine::US9796708, Example 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351738&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208023 386046150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696170 Fc1cccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C24H23ClFN5/c25-20-4-5-22(29-14-15-2-1-3-17(26)12-15)31-23(20)18-8-11-28-24-19(18)13-21(30-24)16-6-9-27-10-7-16/h1-5,8,11-13,16,27H,6-7,9-10,14H2,(H,28,30)(H,29,31) VPFHZZBHFVHILK-UHFFFAOYSA-N 167549 US9073922, 33::US9796708, Example 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167549&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294330 312321394 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696171 Clc1ccc(NCc2cccnc2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C23H23ClN6/c24-19-3-4-21(28-14-15-2-1-8-26-13-15)30-22(19)17-7-11-27-23-18(17)12-20(29-23)16-5-9-25-10-6-16/h1-4,7-8,11-13,16,25H,5-6,9-10,14H2,(H,27,29)(H,28,30) NQQAYRCHKYZLLS-UHFFFAOYSA-N 167550 US9073922, 34::US9796708, Example 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167550&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294331 312321395 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696172 Clc1ccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)cc1 InChI=1S/C24H23Cl2N5/c25-17-3-1-15(2-4-17)14-29-22-6-5-20(26)23(31-22)18-9-12-28-24-19(18)13-21(30-24)16-7-10-27-11-8-16/h1-6,9,12-13,16,27H,7-8,10-11,14H2,(H,28,30)(H,29,31) RWJDKWGWJJVDJB-UHFFFAOYSA-N 167551 US9073922, 35::US9796708, Example 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167551&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294530 312321396 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696173 Fc1ccc(F)c(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C24H22ClF2N5/c25-19-2-4-22(30-13-15-11-16(26)1-3-20(15)27)32-23(19)17-7-10-29-24-18(17)12-21(31-24)14-5-8-28-9-6-14/h1-4,7,10-12,14,28H,5-6,8-9,13H2,(H,29,31)(H,30,32) MFNBASWOPLKFNV-UHFFFAOYSA-N 167552 US9073922, 36::US9796708, Example 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167552&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294531 312321397 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696174 Fc1cncc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C23H22ClFN6/c24-19-1-2-21(29-12-14-9-16(25)13-27-11-14)31-22(19)17-5-8-28-23-18(17)10-20(30-23)15-3-6-26-7-4-15/h1-2,5,8-11,13,15,26H,3-4,6-7,12H2,(H,28,30)(H,29,31) LTVOTZCGCLHPOF-UHFFFAOYSA-N 167553 US9073922, 37::US9796708, Example 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294532 312321398 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696175 Fc1ccccc1CNc1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H23ClFN5/c25-19-5-6-22(29-14-16-3-1-2-4-20(16)26)31-23(19)17-9-12-28-24-18(17)13-21(30-24)15-7-10-27-11-8-15/h1-6,9,12-13,15,27H,7-8,10-11,14H2,(H,28,30)(H,29,31) RVIDFWRHDDLNKW-UHFFFAOYSA-N 167554 US9073922, 38::US9796708, Example 38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167554&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294533 312321399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696176 Fc1ccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)cc1F InChI=1S/C24H22ClF2N5/c25-18-2-4-22(30-13-14-1-3-19(26)20(27)11-14)32-23(18)16-7-10-29-24-17(16)12-21(31-24)15-5-8-28-9-6-15/h1-4,7,10-12,15,28H,5-6,8-9,13H2,(H,29,31)(H,30,32) WSCKPOJEKGJWMD-UHFFFAOYSA-N 167555 US9073922, 39::US9796708, Example 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167555&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86294534 312321400 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696177 Clc1ccc(NCc2ccncc2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C23H23ClN6/c24-19-1-2-21(28-14-15-3-8-25-9-4-15)30-22(19)17-7-12-27-23-18(17)13-20(29-23)16-5-10-26-11-6-16/h1-4,7-9,12-13,16,26H,5-6,10-11,14H2,(H,27,29)(H,28,30) PIWVVOCVVNZKEV-UHFFFAOYSA-N 167556 US9073922, 40::US9796708, Example 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291629 312321401 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696178 [O-][n+]1cccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C23H23ClN6O/c24-19-3-4-21(27-13-15-2-1-11-30(31)14-15)29-22(19)17-7-10-26-23-18(17)12-20(28-23)16-5-8-25-9-6-16/h1-4,7,10-12,14,16,25H,5-6,8-9,13H2,(H,26,28)(H,27,29) YWIKIDIURZHSPD-UHFFFAOYSA-N 60453 US9073922, 41::US9796708, Example 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60453&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291630 313362585 ZINC03221384 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696179 Clc1ccc(NCC2CCNCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C23H29ClN6/c24-19-1-2-21(28-14-15-3-8-25-9-4-15)30-22(19)17-7-12-27-23-18(17)13-20(29-23)16-5-10-26-11-6-16/h1-2,7,12-13,15-16,25-26H,3-6,8-11,14H2,(H,27,29)(H,28,30) JXTUJSKNLLXUDZ-UHFFFAOYSA-N 167557 US9073922, 42::US9796708, Example 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167557&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291631 312321402 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696180 Clc1ccc(NCC2CCCNC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 167558 US9073922, 43::US9796708, Example 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291632 312321403 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696181 Clc1ccc(nc1-c1ccnc2[nH]c(cc12)C1CCNCC1)-c1ccccc1 InChI=1S/C23H21ClN4/c24-19-6-7-20(15-4-2-1-3-5-15)27-22(19)17-10-13-26-23-18(17)14-21(28-23)16-8-11-25-12-9-16/h1-7,10,13-14,16,25H,8-9,11-12H2,(H,26,28) QRPLBFDSCQSEPU-UHFFFAOYSA-N 167559 US9073922, 44::US9796708, Example 44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291634 312321404 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696182 Clc1ccc(NC(=O)c2ccccc2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H22ClN5O/c25-19-6-7-21(30-24(31)16-4-2-1-3-5-16)29-22(19)17-10-13-27-23-18(17)14-20(28-23)15-8-11-26-12-9-15/h1-7,10,13-15,26H,8-9,11-12H2,(H,27,28)(H,29,30,31) AQQKXCPVJHMYRO-UHFFFAOYSA-N 167560 US9073922, 45::US9796708, Example 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291838 312321405 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696183 CN(Cc1ccccc1)c1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H26ClN5/c1-31(16-17-5-3-2-4-6-17)23-8-7-21(26)24(30-23)19-11-14-28-25-20(19)15-22(29-25)18-9-12-27-13-10-18/h2-8,11,14-15,18,27H,9-10,12-13,16H2,1H3,(H,28,29) UNVIDDLDPDEJMZ-UHFFFAOYSA-N 167561 US9073922, 46::US9796708, Example 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291839 312321406 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696184 CCN(Cc1ccccc1)c1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C26H28ClN5/c1-2-32(17-18-6-4-3-5-7-18)24-9-8-22(27)25(31-24)20-12-15-29-26-21(20)16-23(30-26)19-10-13-28-14-11-19/h3-9,12,15-16,19,28H,2,10-11,13-14,17H2,1H3,(H,29,30) WUECQSZGYXSBRB-UHFFFAOYSA-N 167562 US9073922, 47::US9796708, Example 47 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291840 312321407 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696185 Clc1ccc(NCC2CCOCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C23H28ClN5O/c24-19-1-2-21(27-14-15-6-11-30-12-7-15)29-22(19)17-5-10-26-23-18(17)13-20(28-23)16-3-8-25-9-4-16/h1-2,5,10,13,15-16,25H,3-4,6-9,11-12,14H2,(H,26,28)(H,27,29) LGNFTAVRKGAUOE-UHFFFAOYSA-N 167563 US9073922, 48::US9796708, Example 48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167563&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291633 312321408 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696186 Clc1ccc(NCC2CCCOC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 167564 US9073922, 49::US9796708, Example 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167564&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291843 312321409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696187 Clc1ccc(NS(=O)(=O)c2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H23ClN4O2S/c25-22-7-6-17(29-32(30,31)18-4-2-1-3-5-18)14-20(22)19-10-13-27-24-21(19)15-23(28-24)16-8-11-26-12-9-16/h1-7,10,13-16,26,29H,8-9,11-12H2,(H,27,28) DGIVCEYGNCPXQB-UHFFFAOYSA-N 167565 US9073922, 50::US9796708, Example 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 570 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167565&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412421 312321410 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696188 Fc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H25FN4/c26-23-7-6-19(29-16-17-4-2-1-3-5-17)14-21(23)20-10-13-28-25-22(20)15-24(30-25)18-8-11-27-12-9-18/h1-7,10,13-15,18,27,29H,8-9,11-12,16H2,(H,28,30) OQAVAXDSDBEDBE-UHFFFAOYSA-N 167566 US9073922, 51::US9796708, Example 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167566&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412130 312321411 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696189 Clc1cnc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H24ClN5/c25-21-15-29-23(28-14-16-4-2-1-3-5-16)13-19(21)18-8-11-27-24-20(18)12-22(30-24)17-6-9-26-10-7-17/h1-5,8,11-13,15,17,26H,6-7,9-10,14H2,(H,27,30)(H,28,29) NJCLIBSGAOCZBH-UHFFFAOYSA-N 167567 US9073922, 52::US9796708, Example 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167567&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291841 312321412 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696190 Clc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H25ClN4/c26-23-7-6-19(29-16-17-4-2-1-3-5-17)14-21(23)20-10-13-28-25-22(20)15-24(30-25)18-8-11-27-12-9-18/h1-7,10,13-15,18,27,29H,8-9,11-12,16H2,(H,28,30) XLFWWCFTZXANMY-UHFFFAOYSA-N 167568 US9073922, 53::US9796708, Example 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167568&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412023 312321413 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696191 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccccc2)ccc1Cl InChI=1S/C25H26ClN5/c1-31-13-10-18(11-14-31)22-15-20-19(9-12-27-25(20)29-22)24-21(26)7-8-23(30-24)28-16-17-5-3-2-4-6-17/h2-9,12,15,18H,10-11,13-14,16H2,1H3,(H,27,29)(H,28,30) JGJVCBUOCSUBTB-UHFFFAOYSA-N 167569 US9073922, 54::US9796708, Example 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86291842 312321414 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696192 C[C@H](Nc1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1)c1ccccc1 InChI=1S/C25H26ClN5/c1-16(17-5-3-2-4-6-17)29-23-8-7-21(26)24(31-23)19-11-14-28-25-20(19)15-22(30-25)18-9-12-27-13-10-18/h2-8,11,14-16,18,27H,9-10,12-13H2,1H3,(H,28,30)(H,29,31)/t16-/m0/s1 IREGIXRGMGIGLC-INIZCTEOSA-N 167570 US9073922, 55::US9796708, Example 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292043 312321415 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696193 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2ccccc2)n1 InChI=1S/C25H27N5/c1-30-14-11-19(12-15-30)23-16-21-20(10-13-26-25(21)29-23)22-8-5-9-24(28-22)27-17-18-6-3-2-4-7-18/h2-10,13,16,19H,11-12,14-15,17H2,1H3,(H,26,29)(H,27,28) XZWDHOOXCKNIER-UHFFFAOYSA-N 167571 US9073922, 56::US9796708, Example 56 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412379 312321416 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696194 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2cccc(F)c2)ccc1Cl InChI=1S/C25H25ClFN5/c1-32-11-8-17(9-12-32)22-14-20-19(7-10-28-25(20)30-22)24-21(26)5-6-23(31-24)29-15-16-3-2-4-18(27)13-16/h2-7,10,13-14,17H,8-9,11-12,15H2,1H3,(H,28,30)(H,29,31) NWFSYTHPSDOPRY-UHFFFAOYSA-N 167572 US9073922, 57::US9796708, Example 57 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292044 312321417 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696195 Clc1ccc(OCc2ccccc2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H23ClN4O/c25-20-6-7-22(30-15-16-4-2-1-3-5-16)29-23(20)18-10-13-27-24-19(18)14-21(28-24)17-8-11-26-12-9-17/h1-7,10,13-14,17,26H,8-9,11-12,15H2,(H,27,28) WJAHZZJSUQDGQN-UHFFFAOYSA-N 167573 US9073922, 58::US9796708, Example 58 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292045 312321418 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696196 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCNC1 167574 US9073922, 59::US9796708, Example 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167574&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412361 312321419 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696993 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2COCC(C1)N2S(C)(=O)=O 353625 7-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-(methylsulfonyl)-3-oxa-9-azabicyclo[3.3.1]non-6-ene::US9796708, Example 857 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353625&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420164 386047359 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696994 CCOC(=O)NS(=O)(=O)N1C2COCC1C=C(C2)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353626 US9796708, Example 858::ethyl ({7-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-oxa-9-azabicyclo[3.3.1]non-6-en-9-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353626&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208133 386047360 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696995 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2COCC(C1)N2CC(=O)N(C)C 353627 2-{7-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-oxa-9-azabicyclo[3.3.1]non-6-en-9-yl}-N,N-dimethylacetamide::US9796708, Example 859 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353627&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421749 386047361 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696996 CC[C@H](C)[C@H](NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)C(O)=O InChI=1S/C26H30FN3O3/c1-4-15(2)24(26(31)32)29-18-8-5-16(6-9-18)22-14-21-19(11-12-28-25(21)30-22)20-13-17(27)7-10-23(20)33-3/h5,7,10-15,18,24,29H,4,6,8-9H2,1-3H3,(H,28,30)(H,31,32)/t15-,18?,24-/m0/s1 YVHIIEVYVBTMKJ-KWIAJFLMSA-N 353628 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-isoleucine::US9796708, Example 860 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353628&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421338 386047362 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696997 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(C(=O)NC)c(F)c1 InChI=1S/C23H24FN5O5S/c1-3-34-23(31)28-35(32,33)29-10-7-14(8-11-29)20-13-18-16(6-9-26-21(18)27-20)15-4-5-17(19(24)12-15)22(30)25-2/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,25,30)(H,26,27)(H,28,31) HTXMBAIRAXLUDS-UHFFFAOYSA-N 353629 US9796708, Example 861::ethyl {[4-{4-[3-fluoro-4-(methylcarbamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3,6-dihydropyridin-1(2H)-yl]sulfonyl}carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353629&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208134 386047363 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696998 COc1c(F)cccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O3S/c1-27-19-15(4-3-5-17(19)21)14-6-9-22-20-16(14)12-18(23-20)13-7-10-24(11-8-13)28(2,25)26/h3-7,9,12H,8,10-11H2,1-2H3,(H,22,23) ZVOMZAPDQRDKFG-UHFFFAOYSA-N 353630 4-(3-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 862 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 530 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353630&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420531 386047364 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696999 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1OC InChI=1S/C21H21FN4O2/c1-23-21(27)26-10-7-13(8-11-26)18-12-16-14(6-9-24-20(16)25-18)15-4-3-5-17(22)19(15)28-2/h3-7,9,12H,8,10-11H2,1-2H3,(H,23,27)(H,24,25) GBOXOWPGNFGENE-UHFFFAOYSA-N 353631 4-[4-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 863 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 460 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353631&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897404 386047365 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697000 COC(=O)C1NCC(=C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353632 US9796708, Example 864::methyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrole-2-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353632&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419660 386047366 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697001 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC(=O)N1CC(O)C1 InChI=1S/C25H25FN4O4/c1-34-22-3-2-16(26)10-19(22)18-4-7-27-25-20(18)11-21(28-25)15-5-8-29(9-6-15)23(32)12-24(33)30-13-17(31)14-30/h2-5,7,10-11,17,31H,6,8-9,12-14H2,1H3,(H,27,28) TXLVVPBKENDIGO-UHFFFAOYSA-N 353633 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-(3-hydroxyazetidin-1-yl)propane-1,3-dione::US9796708, Example 865 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353633&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897446 386047367 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697002 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](CO)N(C1)S(C)(=O)=O InChI=1S/C20H20FN3O4S/c1-28-19-4-3-13(21)8-16(19)15-5-6-22-20-17(15)9-18(23-20)12-7-14(11-25)24(10-12)29(2,26)27/h3-9,14,25H,10-11H2,1-2H3,(H,22,23)/t14-/m0/s1 FXJKVEWEHNASKO-AWEZNQCLSA-N 353634 US9796708, Example 866::[(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(methylsulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353634&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419577 386047368 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697003 CCOC(=O)NS(=O)(=O)N1CC(=C[C@H]1CO)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O6S/c1-3-33-22(29)26-34(30,31)27-11-13(8-15(27)12-28)19-10-18-16(6-7-24-21(18)25-19)17-9-14(23)4-5-20(17)32-2/h4-10,15,28H,3,11-12H2,1-2H3,(H,24,25)(H,26,29)/t15-/m0/s1 CRBONKUEYNYIBG-HNNXBMFYSA-N 353635 US9796708, Example 867::ethyl {[(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-2,5-dihydro-1H-pyrrol-1-yl]sulfonyl}carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353635&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208135 386047369 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697004 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CC(=O)N1CC(O)C1 InChI=1S/C24H25FN4O5S/c1-34-22-3-2-16(25)10-19(22)18-4-7-26-24-20(18)11-21(27-24)15-5-8-29(9-6-15)35(32,33)14-23(31)28-12-17(30)13-28/h2-5,7,10-11,17,30H,6,8-9,12-14H2,1H3,(H,26,27) TUVMAEOLKZNBMJ-UHFFFAOYSA-N 353636 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 868 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353636&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420366 386047370 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697005 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](CO)NC1 InChI=1S/C19H18FN3O2/c1-25-18-3-2-12(20)7-15(18)14-4-5-21-19-16(14)8-17(23-19)11-6-13(10-24)22-9-11/h2-8,13,22,24H,9-10H2,1H3,(H,21,23)/t13-/m0/s1 RANYXLZNYZCFAZ-ZDUSSCGKSA-N 353637 US9796708, Example 869::{(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrol-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353637&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419945 386047371 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697006 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC2(CC1)NC(=O)NC2=O 353638 8-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,3-diazaspiro[4.5]dec-7-ene-2,4-dione::US9796708, Example 870 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353638&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420475 386047372 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697007 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(N)(CC1)C(O)=O 353639 1-amino-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 871 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353639&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420611 386047373 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697008 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2(CNC2)C1 InChI=1S/C20H20FN3O/c1-25-18-3-2-13(21)6-15(18)14-4-5-23-19-16(14)7-17(24-19)12-8-20(9-12)10-22-11-20/h2-7,12,22H,8-11H2,1H3,(H,23,24) HUAXBAPFXHORLR-UHFFFAOYSA-N 353640 2-(2-azaspiro[3.3]hept-6-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 872 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353640&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420741 386047374 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697009 COc1ccc(F)cc1-c1c(OC)cnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H20FN3O2/c1-25-17-4-3-13(21)9-14(17)19-15-10-16(12-5-7-22-8-6-12)24-20(15)23-11-18(19)26-2/h3-5,9-11,22H,6-8H2,1-2H3,(H,23,24) PSBOBHZYVDTMRM-UHFFFAOYSA-N 353641 4-(5-fluoro-2-methoxyphenyl)-5-methoxy-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 873 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353641&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420640 386047375 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697010 CCOC(=O)c1c([nH]c2nccc(-c3cc(F)ccc3OC)c12)C1=CCNCC1 InChI=1S/C22H22FN3O3/c1-3-29-22(27)19-18-15(16-12-14(23)4-5-17(16)28-2)8-11-25-21(18)26-20(19)13-6-9-24-10-7-13/h4-6,8,11-12,24H,3,7,9-10H2,1-2H3,(H,25,26) LLCRTWYUMAFZHL-UHFFFAOYSA-N 353642 US9796708, Example 874::ethyl 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353642&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420521 386047376 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697011 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CCN(CC1)S(C)(=O)=O InChI=1S/C25H29FN4O5S2/c1-35-24-4-3-18(26)15-21(24)20-5-10-27-25-22(20)16-23(28-25)17-6-11-30(12-7-17)37(33,34)19-8-13-29(14-9-19)36(2,31)32/h3-6,10,15-16,19H,7-9,11-14H2,1-2H3,(H,27,28) GLRQRKRQGBNXGH-UHFFFAOYSA-N 353643 4-(5-fluoro-2-methoxyphenyl)-2-(1-{[1-(methylsulfonyl)piperidin-4-yl]sulfonyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 875 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353643&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419598 386047377 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697012 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CCNS(C)(=O)=O InChI=1S/C22H25FN4O5S2/c1-32-21-4-3-16(23)13-18(21)17-5-8-24-22-19(17)14-20(26-22)15-6-10-27(11-7-15)34(30,31)12-9-25-33(2,28)29/h3-6,8,13-14,25H,7,9-12H2,1-2H3,(H,24,26) NKNIIQKEFYWIDI-UHFFFAOYSA-N 353644 N-[2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)ethyl]methanesulfonamide::US9796708, Example 876 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353644&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420798 386047378 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697013 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(C(CO)C1)S(C)(=O)=O 353645 US9796708, Example 877::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353645&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420331 386047379 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697014 CCOC(=O)NS(=O)(=O)N1CC=C(CC1CO)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353646 US9796708, Example 878::ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353646&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208136 386047380 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697015 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)C(CO)C1 353647 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 879 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353647&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419549 386047381 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697016 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)C)CC2C1 353648 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N,N-dimethylacetamide::US9796708, Example 880 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353648&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419567 386047382 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697017 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O 353649 4-(5-fluoro-2-methoxyphenyl)-2-[2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 881 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353649&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413643 386047383 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697018 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(NC1)C(=O)N(C)C 353650 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethyl-2,5-dihydro-1H-pyrrole-2-carboxamide::US9796708, Example 882 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353650&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419633 386047384 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697019 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C28H34FN5O2/c1-32(2)27(35)18-33-12-9-21(10-13-33)34-14-7-19(8-15-34)25-17-24-22(6-11-30-28(24)31-25)23-16-20(29)4-5-26(23)36-3/h4-7,11,16-17,21H,8-10,12-15,18H2,1-3H3,(H,30,31) QQTPTCQVZPIIAJ-UHFFFAOYSA-N 353651 2-(4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}piperidin-1-yl)-N,N-dimethylacetamide::US9796708, Example 883 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353651&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421054 386047385 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697020 OC(=O)CNC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F 353652 N-{4-[4-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}glycine::US9796708, Example 884 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353652&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419958 386047386 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697021 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CN(C1)C(C)=O InChI=1S/C24H25FN4O4S/c1-15(30)28-13-18(14-28)34(31,32)29-9-6-16(7-10-29)22-12-21-19(5-8-26-24(21)27-22)20-11-17(25)3-4-23(20)33-2/h3-6,8,11-12,18H,7,9-10,13-14H2,1-2H3,(H,26,27) UMBLFGRGEXPIOP-UHFFFAOYSA-N 353653 1-[3-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)azetidin-1-yl]ethanone::US9796708, Example 885 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353653&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897398 386047387 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697022 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CN(C1)S(C)(=O)=O InChI=1S/C23H25FN4O5S2/c1-33-22-4-3-16(24)11-19(22)18-5-8-25-23-20(18)12-21(26-23)15-6-9-27(10-7-15)35(31,32)17-13-28(14-17)34(2,29)30/h3-6,8,11-12,17H,7,9-10,13-14H2,1-2H3,(H,25,26) JUKBVZBNERHTJN-UHFFFAOYSA-N 353654 4-(5-fluoro-2-methoxyphenyl)-2-(1-{[1-(methylsulfonyl)azetidin-3-yl]sulfonyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 886 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353654&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420050 386047388 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697023 CCOC(=O)c1c([nH]c2nccc(-c3cc(F)ccc3OC)c12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H24FN3O5S/c1-4-32-23(28)20-19-16(17-13-15(24)5-6-18(17)31-2)7-10-25-22(19)26-21(20)14-8-11-27(12-9-14)33(3,29)30/h5-8,10,13H,4,9,11-12H2,1-3H3,(H,25,26) APCIEGUPNCWMGN-UHFFFAOYSA-N 353655 US9796708, Example 887::ethyl 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419512 386047389 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697024 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCNCC1 InChI=1S/C20H20FN3O/c1-25-19-5-4-14(21)11-16(19)15-7-10-23-20-17(15)12-18(24-20)13-3-2-8-22-9-6-13/h3-5,7,10-12,22H,2,6,8-9H2,1H3,(H,23,24) KTLJVIHGVUCSAW-UHFFFAOYSA-N 353656 4-(5-fluoro-2-methoxyphenyl)-2-(2,3,6,7-tetrahydro-1H-azepin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 888 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353656&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419836 386047390 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697025 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CN1C(=O)CNC1=O InChI=1S/C24H22FN5O4/c1-34-20-3-2-15(25)10-17(20)16-4-7-26-23-18(16)11-19(28-23)14-5-8-29(9-6-14)22(32)13-30-21(31)12-27-24(30)33/h2-5,7,10-11H,6,8-9,12-13H2,1H3,(H,26,28)(H,27,33) CDPKIYMMADFOKR-UHFFFAOYSA-N 353657 3-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)imidazolidine-2,4-dione::US9796708, Example 889 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353657&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419909 386047391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697026 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CC#N InChI=1S/C21H19FN4O3S/c1-29-20-3-2-15(22)12-17(20)16-4-8-24-21-18(16)13-19(25-21)14-5-9-26(10-6-14)30(27,28)11-7-23/h2-5,8,12-13H,6,9-11H2,1H3,(H,24,25) HKWVBBBEFKHILF-UHFFFAOYSA-N 353658 ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)acetonitrile::US9796708, Example 890 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353658&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419647 386047392 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697027 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OC(C)C InChI=1S/C23H25FN4O5S/c1-14(2)33-23(29)27-34(30,31)28-10-7-15(8-11-28)20-13-19-17(6-9-25-22(19)26-20)18-12-16(24)4-5-21(18)32-3/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,25,26)(H,27,29) NGCRLYYLCNNRCR-UHFFFAOYSA-N 353659 US9796708, Example 891::propan-2-yl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353659&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420870 386047393 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697028 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2(C1)CN(C2)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-28-19-4-3-14(22)7-16(19)15-5-6-23-20-17(15)8-18(24-20)13-9-21(10-13)11-25(12-21)29(2,26)27/h3-8,13H,9-12H2,1-2H3,(H,23,24) NINIGWQPWTZUID-UHFFFAOYSA-N 353660 4-(5-fluoro-2-methoxyphenyl)-2-[2-(methylsulfonyl)-2-azaspiro[3.3]hept-6-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 892 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353660&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420871 386047394 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697029 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(c(cnc2[nH]1)C#N)-c1cc(F)ccc1OC InChI=1S/C23H22FN5O5S/c1-3-34-23(30)28-35(31,32)29-8-6-14(7-9-29)19-11-18-21(15(12-25)13-26-22(18)27-19)17-10-16(24)4-5-20(17)33-2/h4-6,10-11,13H,3,7-9H2,1-2H3,(H,26,27)(H,28,30) TXDIASXPLFOKSJ-UHFFFAOYSA-N 353661 US9796708, Example 893::ethyl ({4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353661&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208137 386047395 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697030 CS(=O)(=O)NCCOc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H25FN4O5S2/c1-33(28,29)25-9-12-32-21-4-3-16(23)13-18(21)17-5-8-24-22-19(17)14-20(26-22)15-6-10-27(11-7-15)34(2,30)31/h3-6,8,13-14,25H,7,9-12H2,1-2H3,(H,24,26) OUSBQHCIHLMFKW-UHFFFAOYSA-N 353662 N-[2-(4-fluoro-2-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenoxy)ethyl]methanesulfonamide::US9796708, Example 894 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353662&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420181 386047396 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697031 NCCOc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H21FN4O/c21-14-1-2-19(26-10-6-22)16(11-14)15-5-9-24-20-17(15)12-18(25-20)13-3-7-23-8-4-13/h1-3,5,9,11-12,23H,4,6-8,10,22H2,(H,24,25) QYFYTKYYKSGPDV-UHFFFAOYSA-N 353663 2-{4-fluoro-2-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenoxy}) ethanamine::US9796708, Example 895 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353663&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420353 386047397 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697032 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccc(NS(C)(=O)=O)cc2)CC1 InChI=1S/C27H27FN4O3S/c1-35-26-8-5-20(28)15-23(26)22-9-12-29-27-24(22)16-25(30-27)19-10-13-32(14-11-19)17-18-3-6-21(7-4-18)31-36(2,33)34/h3-10,12,15-16,31H,11,13-14,17H2,1-2H3,(H,29,30) ZFNAKTZIZVPJQD-UHFFFAOYSA-N 353664 N-[4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)phenyl]methanesulfonamide::US9796708, Example 896 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353664&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419812 386047398 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697033 CNc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C24H27FN4O2/c1-24(2,3)31-23(30)29-11-8-15(9-12-29)21-14-19-17(7-10-27-22(19)28-21)18-13-16(25)5-6-20(18)26-4/h5-8,10,13-14,26H,9,11-12H2,1-4H3,(H,27,28) LJRMVKPHCPDBFZ-UHFFFAOYSA-N 353665 US9796708, Example 897::tert-butyl 4-{4-[5-fluoro-2-(methylamino)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3,6-dihydropyridine-1(2H)-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 890 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353665&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419868 386047399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697034 CNc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H19FN4/c1-21-17-3-2-13(20)10-15(17)14-6-9-23-19-16(14)11-18(24-19)12-4-7-22-8-5-12/h2-4,6,9-11,21-22H,5,7-8H2,1H3,(H,23,24) AWHOCAXFBHTAFQ-UHFFFAOYSA-N 353666 4-fluoro-N-methyl-2-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 898 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353666&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420728 386047400 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697035 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(N)(CC1)C(=O)N(C)C 353667 1-amino-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,N-dimethylcyclohex-3-ene-1-carboxamide::US9796708, Example 899 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353667&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419988 386047401 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697036 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCNCCO InChI=1S/C24H28FN5O3/c1-33-22-3-2-17(25)14-19(22)18-4-7-27-23-20(18)15-21(29-23)16-5-11-30(12-6-16)24(32)28-9-8-26-10-13-31/h2-5,7,14-15,26,31H,6,8-13H2,1H3,(H,27,29)(H,28,32) CSJXGUHPAJOPAW-UHFFFAOYSA-N 353569 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{2-[(2-hydroxyethyl)amino]ethyl}-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 801::US9796708, Example 900 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419871 386047308 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697037 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC(=O)N1CCC[C@H]1C(N)=O InChI=1S/C27H28FN5O4/c1-37-23-5-4-17(28)13-19(23)18-6-9-30-27-20(18)14-21(31-27)16-7-11-32(12-8-16)24(34)15-25(35)33-10-2-3-22(33)26(29)36/h4-7,9,13-14,22H,2-3,8,10-12,15H2,1H3,(H2,29,36)(H,30,31)/t22-/m0/s1 AFVIUPSUKCORKL-QFIPXVFZSA-N 353669 1-(3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-oxopropanoyl)prolinamide::US9796708, Example 901 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353669&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419579 386047402 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697038 CCONC(=O)C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353670 N-ethoxy-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 902 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353670&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420177 386047403 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697039 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C(N)=O)c12)C1=CCNCC1 InChI=1S/C20H19FN4O2/c1-27-15-3-2-12(21)10-14(15)13-6-9-24-20-16(13)17(19(22)26)18(25-20)11-4-7-23-8-5-11/h2-4,6,9-10,23H,5,7-8H2,1H3,(H2,22,26)(H,24,25) CLAPRAMXKREODD-UHFFFAOYSA-N 353671 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US9796708, Example 903 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353671&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419745 386047404 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697040 CCOC(=O)NS(=O)(=O)N1C2CCC1C=C(C2)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353672 US9796708, Example 904::ethyl ({3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 105 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353672&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208138 386047405 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697041 COc1ccc(CNS(=O)(=O)C2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)cc1 353673 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(4-methoxybenzyl)cyclohex-3-ene-1-sulfonamide::US9796708, Example 905 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353673&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419840 386047406 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697042 COC(=O)c1cccnc1N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C26H23FN4O3/c1-33-23-6-5-17(27)14-20(23)18-7-11-28-24-21(18)15-22(30-24)16-8-12-31(13-9-16)25-19(26(32)34-2)4-3-10-29-25/h3-8,10-11,14-15H,9,12-13H2,1-2H3,(H,28,30) YTFKUHWTHCVUKO-UHFFFAOYSA-N 353674 US9796708, Example 906::methyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydro-2H-1,2'-bipyridine-3'-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353674&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420413 386047407 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697043 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1 InChI=1S/C26H30FN5O3/c1-35-23-5-4-17(27)13-19(23)18-6-9-29-26-20(18)14-21(30-26)16-7-11-31(12-8-16)15-24(33)32-10-2-3-22(32)25(28)34/h4-6,9,13-14,16,22H,2-3,7-8,10-12,15H2,1H3,(H2,28,34)(H,29,30)/t22-/m0/s1 AZKYGTOKEMZGBS-QFIPXVFZSA-N 353675 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetyl)-L-prolinamide::US9796708, Example 907 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353675&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420732 386047408 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697044 COC(=O)[C@@H]1CC(CN1C(=O)OC(C)(C)C)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C30H35FN4O5/c1-30(2,3)40-29(37)35-17-20(15-25(35)28(36)39-5)34-12-9-18(10-13-34)24-16-23-21(8-11-32-27(23)33-24)22-14-19(31)6-7-26(22)38-4/h6-9,11,14,16,20,25H,10,12-13,15,17H2,1-5H3,(H,32,33)/t20?,25-/m0/s1 ZRGYEPMPXCSVCQ-KUXBLMNESA-N 353676 1-tert-butyl 2-methyl (2S)-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}pyrrolidine-1,2-dicarboxylate::US9796708, Example 908 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353676&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131746436 386047409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697045 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1ncccc1C(O)=O InChI=1S/C25H21FN4O3/c1-33-22-5-4-16(26)13-19(22)17-6-10-27-23-20(17)14-21(29-23)15-7-11-30(12-8-15)24-18(25(31)32)3-2-9-28-24/h2-7,9-10,13-14H,8,11-12H2,1H3,(H,27,29)(H,31,32) GANIGPYDAWLMIQ-UHFFFAOYSA-N 353677 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydro-2H-1,2'-bipyridine-3'-carboxylic acid::US9796708, Example 909 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353677&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420620 386047410 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696197 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCNC1 167575 US9073922, 60::US9796708, Example 60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167575&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412836 312321420 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696198 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CCNC1 InChI=1S/C18H18FN3O/c1-23-17-3-2-12(19)8-14(17)13-5-7-21-18-15(13)9-16(22-18)11-4-6-20-10-11/h2-3,5,7-9,11,20H,4,6,10H2,1H3,(H,21,22)/t11-/m0/s1 RGVDQTXHXAFWIN-NSHDSACASA-N 167576 US9073922, 61::US9796708, Example 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167576&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413732 312321421 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696199 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@@H]1CCNC1 InChI=1S/C18H18FN3O/c1-23-17-3-2-12(19)8-14(17)13-5-7-21-18-15(13)9-16(22-18)11-4-6-20-10-11/h2-3,5,7-9,11,20H,4,6,10H2,1H3,(H,21,22)/t11-/m1/s1 RGVDQTXHXAFWIN-LLVKDONJSA-N 167577 US9073922, 62::US9796708, Example 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413651 312321422 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696200 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(C)C1 167578 US9073922, 63::US9796708, Example 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412305 312321423 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696201 Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(cc12)C1CCNC1 167579 US9073922, 64::US9796708, Example 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292046 312321424 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696202 Clc1ccc(NCC2CCOCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNC1 167580 US9073922, 65::US9796708, Example 65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292047 312321425 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696203 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CNCCO1 167581 US9073922, 66::US9796708, Example 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167581&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412635 312321426 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696204 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CNCCO1 167582 US9073922, 67::US9796708, Example 67 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412464 312321427 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696205 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CN(C)CCO1 167583 US9073922, 68::US9796708, Example 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 510 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167583&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412104 312321428 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696206 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(C)CCO1 167584 US9073922, 69::US9796708, Example 69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411761 312321429 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696207 Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(cc12)C1CNCCO1 167585 US9073922, 70::US9796708, Example 70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292048 312321430 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696208 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CNC(C)(C)CO1 167586 US9073922, 71::US9796708, Example 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167586&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411378 312321431 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696209 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CNC(C)(C)CO1 167587 US9073922, 72::US9796708, Example 72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 360 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412291 312321432 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696210 COc1cc(Cl)ccc1-c1ccnc2[nH]c(cc12)C1CNC(C)(C)CO1 167588 US9073922, 73::US9796708, Example 73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412166 312321433 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696211 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CC[C@H](N)CC1 351781 US9796708, Example 74::trans-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohexanamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351781&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412575 386046191 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696212 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCC(N)C1 167590 US9073922, 75::US9796708, Example 75 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167590&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412245 312321435 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696213 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3)c(C)c12 InChI=1S/C20H22FN3O/c1-12-18-15(16-11-14(21)3-4-17(16)25-2)7-10-23-20(18)24-19(12)13-5-8-22-9-6-13/h3-4,7,10-11,13,22H,5-6,8-9H2,1-2H3,(H,23,24) FOUFXOREBSDCBF-UHFFFAOYSA-N 167591 US9073922, 76::US9796708, Example 76 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412177 312321436 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696214 Clc1cnc2[nH]c(cc2c1-c1cccc(NCc2ccccc2)n1)C1CCNCC1 InChI=1S/C24H24ClN5/c25-19-15-28-24-18(13-21(30-24)17-9-11-26-12-10-17)23(19)20-7-4-8-22(29-20)27-14-16-5-2-1-3-6-16/h1-8,13,15,17,26H,9-12,14H2,(H,27,29)(H,28,30) OKINEZSFMAVHAZ-UHFFFAOYSA-N 167592 US9073922, 77::US9796708, Example 77 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167592&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292234 312321437 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696215 Fc1cccc(c1)-c1c(Cl)cnc2[nH]c(cc12)C1CCCNC1 167593 US9073922, 78::US9796708, Example 78 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167593&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412497 312321438 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696216 Fc1cccc(n1)-c1c(Cl)cnc2[nH]c(cc12)C1CCCNC1 167594 US9073922, 79::US9796708, Example 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 840 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167594&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292235 312321439 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696217 Clc1cnc2[nH]c(cc2c1-c1cccc(NCc2ccccc2)n1)C1CCCNC1 167595 US9073922, 80::US9796708, Example 80 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167595&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292236 312321440 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696218 Clc1cnc2[nH]c(cc2c1-c1cccc(NCC2CCOCC2)n1)C1CCCNC1 167596 US9073922, 81::US9796708, Example 81 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 640 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167596&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292237 312321441 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696219 CN1CCCC(C1)c1cc2c(c(Cl)cnc2[nH]1)-c1cccc(NCc2ccccc2)n1 167597 US9073922, 82::US9796708, Example 82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292238 312321442 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696220 COC(=O)N1CCCC(C1)c1cc2c(c(Cl)cnc2[nH]1)-c1cccc(NCc2ccccc2)n1 167598 US9073922, 83::US9796708, Example 83 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412259 312321443 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696221 CC(C)S(=O)(=O)N1CCCC(C1)c1cc2c(c(Cl)cnc2[nH]1)-c1cccc(NCc2ccccc2)n1 167599 US9073922, 84::US9796708, Example 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167599&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292239 312321444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696222 NC1CCCC(C1)c1cc2c(c(Cl)cnc2[nH]1)-c1cccc(F)c1 167600 US9073922, 85::US9796708, Example 85 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167600&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412477 312321445 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696223 NC1CCCC(C1)c1cc2c(c(Cl)cnc2[nH]1)-c1cccc(NCc2ccccc2)n1 167601 US9073922, 86::US9796708, Example 86 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167601&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292427 312321446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696224 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H18FN3O/c1-24-18-3-2-13(20)10-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-4,6,9-11,21H,5,7-8H2,1H3,(H,22,23) BHDZLFHFYYIDMB-UHFFFAOYSA-N 167602 US9073922, 87::US9796708, Example 87 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167602&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411400 312321447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696225 C(Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1)C1CCOCC1 InChI=1S/C23H29N5O/c1-2-20(27-22(3-1)26-15-16-7-12-29-13-8-16)18-6-11-25-23-19(18)14-21(28-23)17-4-9-24-10-5-17/h1-3,6,11,14,16-17,24H,4-5,7-10,12-13,15H2,(H,25,28)(H,26,27) RLFBKWJWTVRCQF-UHFFFAOYSA-N 167603 US9073922, 88::US9796708, Example 88 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167603&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292428 312321448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696226 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CCOCC2)n1 InChI=1S/C24H31N5O/c1-29-11-6-18(7-12-29)22-15-20-19(5-10-25-24(20)28-22)21-3-2-4-23(27-21)26-16-17-8-13-30-14-9-17/h2-5,10,15,17-18H,6-9,11-14,16H2,1H3,(H,25,28)(H,26,27) SRKUKIVBBDFOGG-UHFFFAOYSA-N 167604 US9073922, 89::US9796708, Example 89 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167604&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292429 312321449 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696227 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCCc2ccccc2)n1 InChI=1S/C27H31N5/c1-32-17-13-21(14-18-32)25-19-23-22(12-16-29-27(23)31-25)24-10-5-11-26(30-24)28-15-6-9-20-7-3-2-4-8-20/h2-5,7-8,10-12,16,19,21H,6,9,13-15,17-18H2,1H3,(H,28,30)(H,29,31) GQNURJDUNFQWGU-UHFFFAOYSA-N 60454 US9073922, 90::US9796708, Example 90 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292430 313362586 ZINC03253956 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696228 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cccnc2)n1 InChI=1S/C24H26N6/c1-30-12-8-18(9-13-30)22-14-20-19(7-11-26-24(20)29-22)21-5-2-6-23(28-21)27-16-17-4-3-10-25-15-17/h2-7,10-11,14-15,18H,8-9,12-13,16H2,1H3,(H,26,29)(H,27,28) UXGWTGHPHHLGRU-UHFFFAOYSA-N 167605 US9073922, 91::US9796708, Example 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167605&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292431 312321450 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696229 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCSc2ccccc2)n1 InChI=1S/C26H29N5S/c1-31-15-11-19(12-16-31)24-18-22-21(10-13-28-26(22)30-24)23-8-5-9-25(29-23)27-14-17-32-20-6-3-2-4-7-20/h2-10,13,18-19H,11-12,14-17H2,1H3,(H,27,29)(H,28,30) XVLFUTCJAMCEBO-UHFFFAOYSA-N 167606 US9073922, 92::US9796708, Example 92 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167606&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412261 312321451 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696230 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CC2)n1 InChI=1S/C22H27N5/c1-27-11-8-16(9-12-27)20-13-18-17(7-10-23-22(18)26-20)19-3-2-4-21(25-19)24-14-15-5-6-15/h2-4,7,10,13,15-16H,5-6,8-9,11-12,14H2,1H3,(H,23,26)(H,24,25) NGOCBVFPEURUQH-UHFFFAOYSA-N 167607 US9073922, 93::US9796708, Example 93 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167607&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413760 312321452 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696231 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN1 167608 US9073922, 94::US9796708, Example 94 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 580 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167608&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411900 312321453 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696232 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CCOC(C)(C)C2)n1 167609 US9073922, 95::US9796708, Example 95 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167609&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292628 312321454 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696233 CN(Cc1ccccc1)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C26H29N5/c1-30-15-12-20(13-16-30)24-17-22-21(11-14-27-26(22)29-24)23-9-6-10-25(28-23)31(2)18-19-7-4-3-5-8-19/h3-11,14,17,20H,12-13,15-16,18H2,1-2H3,(H,27,29) LOWTYMOPTFLWHN-UHFFFAOYSA-N 167610 US9073922, 96::US9796708, Example 96 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167610&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292432 312321455 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696234 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cccc(Cl)c2)n1 InChI=1S/C25H26ClN5/c1-31-12-9-18(10-13-31)23-15-21-20(8-11-27-25(21)30-23)22-6-3-7-24(29-22)28-16-17-4-2-5-19(26)14-17/h2-8,11,14-15,18H,9-10,12-13,16H2,1H3,(H,27,30)(H,28,29) MQWRXIFGIPESEO-UHFFFAOYSA-N 167611 US9073922, 97::US9796708, Example 97 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167611&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292629 312321456 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696235 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCCC1 InChI=1S/C20H21FN2O/c1-24-19-8-7-14(21)11-16(19)15-9-10-22-20-17(15)12-18(23-20)13-5-3-2-4-6-13/h7-13H,2-6H2,1H3,(H,22,23) OHEICDBMWKDSFY-UHFFFAOYSA-N 167612 US9073922, 98::US9796708, Example 98 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167612&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411538 312321457 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696236 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN1C(C)=O 167613 US9073922, 99::US9796708, Example 99 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167613&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412310 312321458 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696237 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(C)=O InChI=1S/C21H20FN3O2/c1-13(26)25-9-6-14(7-10-25)19-12-18-16(5-8-23-21(18)24-19)17-11-15(22)3-4-20(17)27-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,24) XHJXGNSUJCRMHR-UHFFFAOYSA-N 167614 US9073922, 100::US9796708, Example 100 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167614&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414060 312321459 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696238 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO InChI=1S/C21H20FN3O3/c1-28-19-3-2-14(22)10-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)20(27)12-26/h2-5,7,10-11,26H,6,8-9,12H2,1H3,(H,23,24) NAWNCEFBLJLRNH-UHFFFAOYSA-N 167615 US9073922, 101::US9796708, Example 101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167615&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412498 312321460 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696239 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2c(F)cccc2F)n1 InChI=1S/C25H25F2N5/c1-32-12-9-16(10-13-32)23-14-18-17(8-11-28-25(18)31-23)22-6-3-7-24(30-22)29-15-19-20(26)4-2-5-21(19)27/h2-8,11,14,16H,9-10,12-13,15H2,1H3,(H,28,31)(H,29,30) KPWHDYVGBKHBGV-UHFFFAOYSA-N 167616 US9073922, 102::US9796708, Example 102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167616&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292630 312321461 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696240 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN1C 167617 US9073922, 103::US9796708, Example 103 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 430 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167617&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412045 312321462 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696241 C[C@H](Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1)c1ccccc1 InChI=1S/C26H29N5/c1-18(19-7-4-3-5-8-19)28-25-10-6-9-23(29-25)21-11-14-27-26-22(21)17-24(30-26)20-12-15-31(2)16-13-20/h3-11,14,17-18,20H,12-13,15-16H2,1-2H3,(H,27,30)(H,28,29)/t18-/m0/s1 HYKZYNURSOQFMM-SFHVURJKSA-N 167618 US9073922, 104::US9796708, Example 104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167618&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292633 312321463 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696242 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2ccc3OCOc3c2)n1 InChI=1S/C26H27N5O2/c1-31-11-8-18(9-12-31)22-14-20-19(7-10-27-26(20)30-22)21-3-2-4-25(29-21)28-15-17-5-6-23-24(13-17)33-16-32-23/h2-7,10,13-14,18H,8-9,11-12,15-16H2,1H3,(H,27,30)(H,28,29) WZYMEKZRUAABBC-UHFFFAOYSA-N 167619 US9073922, 105::US9796708, Example 105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167619&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292631 312321464 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696243 Nc1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C17H18ClN5/c18-13-1-2-15(19)23-16(13)11-5-8-21-17-12(11)9-14(22-17)10-3-6-20-7-4-10/h1-2,5,8-10,20H,3-4,6-7H2,(H2,19,23)(H,21,22) QOSQVDOBHGDBJD-UHFFFAOYSA-N 167620 US9073922, 106::US9796708, Example 106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167620&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292632 312321465 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696244 C(CSc1ccccc1)Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H27N5S/c1-2-5-19(6-3-1)31-16-15-27-24-8-4-7-22(29-24)20-11-14-28-25-21(20)17-23(30-25)18-9-12-26-13-10-18/h1-8,11,14,17-18,26H,9-10,12-13,15-16H2,(H,27,29)(H,28,30) MELQQGZRLXAIAJ-UHFFFAOYSA-N 167621 US9073922, 107::US9796708, Example 107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167621&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292823 312321466 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696245 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(C1)C(C)=O 167622 US9073922, 108::US9796708, Example 108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167622&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412008 312321467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696246 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCO)C1 167623 US9073922, 109::US9796708, Example 109 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167623&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412225 312321468 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696247 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(C1)C1CCOCC1 167624 US9073922, 110::US9796708, Example 110 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167624&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412136 312321469 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696248 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccccn2)C1 167625 US9073922, 111::US9796708, Example 111 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167625&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411847 312321470 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696249 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2cccnc2)C1 167626 US9073922, 112::US9796708, Example 112 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167626&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411752 312321471 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696250 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccncc2)C1 167627 US9073922, 113::US9796708, Example 113 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167627&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412307 312321472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697046 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(NC(C)=O)c(=O)c1=O InChI=1S/C25H21FN4O4/c1-13(31)28-21-22(24(33)23(21)32)30-9-6-14(7-10-30)19-12-18-16(5-8-27-25(18)29-19)17-11-15(26)3-4-20(17)34-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,27,29)(H,28,31) VNMOXIGMGTWUHC-UHFFFAOYSA-N 353678 N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3,4-dioxocyclobut-1-en-1-yl)acetamide::US9796708, Example 910 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353678&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208139 386047411 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697047 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(NS(C)(=O)=O)c(=O)c1=O InChI=1S/C24H21FN4O5S/c1-34-19-4-3-14(25)11-16(19)15-5-8-26-24-17(15)12-18(27-24)13-6-9-29(10-7-13)21-20(22(30)23(21)31)28-35(2,32)33/h3-6,8,11-12,28H,7,9-10H2,1-2H3,(H,26,27) KCQRVEFJFWJBHF-UHFFFAOYSA-N 353679 N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3,4-dioxocyclobut-1-en-1-yl)methanesulfonamide::US9796708, Example 911 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353679&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208140 386047412 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697048 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(O)c(=O)c1=O InChI=1S/C23H18FN3O4/c1-31-18-3-2-13(24)10-15(18)14-4-7-25-23-16(14)11-17(26-23)12-5-8-27(9-6-12)19-20(28)22(30)21(19)29/h2-5,7,10-11,28H,6,8-9H2,1H3,(H,25,26) LESOKHQQAVKFKG-UHFFFAOYSA-N 353680 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-4-hydroxycyclobut-3-ene-1,2-dione::US9796708, Example 912 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353680&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208141 386047413 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697049 COC(=O)[C@@H]1CC(CN1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H27FN4O3/c1-32-23-4-3-16(26)11-19(23)18-5-8-27-24-20(18)13-21(29-24)15-6-9-30(10-7-15)17-12-22(28-14-17)25(31)33-2/h3-6,8,11,13,17,22,28H,7,9-10,12,14H2,1-2H3,(H,27,29)/t17?,22-/m0/s1 ASGAHXDLHPODHU-UGNFMNBCSA-N 353681 US9796708, Example 913::methyl 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-L-prolinate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353681&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419582 386047414 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697050 COC(=O)[C@@H]1CC(CN1S(C)(=O)=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C26H29FN4O5S/c1-35-24-5-4-17(27)12-20(24)19-6-9-28-25-21(19)14-22(29-25)16-7-10-30(11-8-16)18-13-23(26(32)36-2)31(15-18)37(3,33)34/h4-7,9,12,14,18,23H,8,10-11,13,15H2,1-3H3,(H,28,29)/t18?,23-/m0/s1 RERVNTWUFXJLSE-IMMUGOHXSA-N 353682 US9796708, Example 914::methyl 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(methylsulfonyl)-L-prolinate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353682&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897297 386047415 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697051 CCOC(=O)C1CN(CC1N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)S(C)(=O)=O 353683 US9796708, Example 915::ethyl 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(methylsulfonyl)pyrrolidine-3-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353683&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421347 386047416 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697052 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC1)C(=O)CO InChI=1S/C22H19FN4O3/c1-30-18-3-2-14(23)10-16(18)15-4-7-25-22-20(15)17(11-24)21(26-22)13-5-8-27(9-6-13)19(29)12-28/h2-5,7,10,28H,6,8-9,12H2,1H3,(H,25,26) SHPRGEKBMSYZFX-UHFFFAOYSA-N 353684 4-(5-fluoro-2-methoxyphenyl)-2-[1-(hydroxyacetyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 916 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353684&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420449 386047417 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697053 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(O)CO)CC1 353685 2-[1-(2,3-dihydroxypropyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 917 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353685&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419571 386047418 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697054 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1C#N InChI=1S/C23H22FN5O5S/c1-3-34-23(30)28-35(31,32)29-10-7-14(8-11-29)21-18(13-25)20-16(6-9-26-22(20)27-21)17-12-15(24)4-5-19(17)33-2/h4-7,9,12H,3,8,10-11H2,1-2H3,(H,26,27)(H,28,30) BBJLKGMUUKDJMI-UHFFFAOYSA-N 353686 US9796708, Example 918::ethyl ({4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353686&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208142 386047419 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697055 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C(N)=O)c12)C1=CCN(CC(O)CO)CC1 353687 2-[1-(2,3-dihydroxypropyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US9796708, Example 919 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 380 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353687&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420352 386047420 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697056 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1C(N)=O InChI=1S/C23H24FN5O6S/c1-3-35-23(31)28-36(32,33)29-10-7-13(8-11-29)20-19(21(25)30)18-15(6-9-26-22(18)27-20)16-12-14(24)4-5-17(16)34-2/h4-7,9,12H,3,8,10-11H2,1-2H3,(H2,25,30)(H,26,27)(H,28,31) NUXSOWPFODALED-UHFFFAOYSA-N 353688 US9796708, Example 920::ethyl ({4-[3-carbamoyl-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 520 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353688&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208143 386047421 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697057 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)S(N)(=O)=O 353689 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-sulfonamide::US9796708, Example 921 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353689&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420785 386047422 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697058 CNC(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1C(N)=O InChI=1S/C22H22FN5O3/c1-25-22(30)28-9-6-12(7-10-28)19-18(20(24)29)17-14(5-8-26-21(17)27-19)15-11-13(23)3-4-16(15)31-2/h3-6,8,11H,7,9-10H2,1-2H3,(H2,24,29)(H,25,30)(H,26,27) YDYXHXODGVZBNI-UHFFFAOYSA-N 353690 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylcarbamoyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US9796708, Example 922 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353690&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419862 386047423 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697059 CCOC(=O)NS(=O)(=O)N1CC2(CC(C2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)C1 InChI=1S/C23H25FN4O5S/c1-3-33-22(29)27-34(30,31)28-12-23(13-28)10-14(11-23)19-9-18-16(6-7-25-21(18)26-19)17-8-15(24)4-5-20(17)32-2/h4-9,14H,3,10-13H2,1-2H3,(H,25,26)(H,27,29) SKVFCLTVAOHXFF-UHFFFAOYSA-N 353691 US9796708, Example 923::ethyl ({6-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-azaspiro[3.3]hept-2-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353691&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208144 386047424 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697060 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2(C1)CN(CC(O)CO)C2 353692 3-{6-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-azaspiro[3.3]hept-2-yl}propane-1,2-diol::US9796708, Example 924 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353692&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421221 386047425 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697061 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2(C1)CN(CC(=O)N(C)C)C2 InChI=1S/C24H27FN4O2/c1-28(2)22(30)12-29-13-24(14-29)10-15(11-24)20-9-19-17(6-7-26-23(19)27-20)18-8-16(25)4-5-21(18)31-3/h4-9,15H,10-14H2,1-3H3,(H,26,27) JJXYHHZIIKLFNO-UHFFFAOYSA-N 353693 2-{6-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-azaspiro[3.3]hept-2-yl}-N,N-dimethylacetamide::US9796708, Example 925 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353693&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420243 386047426 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697062 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CC(=O)NC1CC(O)C1 InChI=1S/C25H27FN4O5S/c1-35-23-3-2-16(26)10-20(23)19-4-7-27-25-21(19)13-22(29-25)15-5-8-30(9-6-15)36(33,34)14-24(32)28-17-11-18(31)12-17/h2-5,7,10,13,17-18,31H,6,8-9,11-12,14H2,1H3,(H,27,29)(H,28,32) WFTWWBNUPBXKQI-UHFFFAOYSA-N 353694 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)-N-(3-hydroxycyclobutyl)acetamide::US9796708, Example 926 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353694&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421100 386047427 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697063 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1C[C@H](N(C1)S(C)(=O)=O)C(O)=O InChI=1S/C25H27FN4O5S/c1-35-23-4-3-16(26)11-19(23)18-5-8-27-24-20(18)13-21(28-24)15-6-9-29(10-7-15)17-12-22(25(31)32)30(14-17)36(2,33)34/h3-6,8,11,13,17,22H,7,9-10,12,14H2,1-2H3,(H,27,28)(H,31,32)/t17?,22-/m0/s1 MJMXSVXOLMVBMM-UGNFMNBCSA-N 353695 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(methylsulfonyl)-L-proline::US9796708, Example 927 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353695&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897252 386047428 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697064 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CN(CC1C(O)=O)S(C)(=O)=O 353696 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(methylsulfonyl)pyrrolidine-3-carboxylic acid::US9796708, Example 928 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353696&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419791 386047429 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697065 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N1CCC1 InChI=1S/C22H23FN4O3S/c1-30-21-4-3-16(23)13-18(21)17-5-8-24-22-19(17)14-20(25-22)15-6-11-27(12-7-15)31(28,29)26-9-2-10-26/h3-6,8,13-14H,2,7,9-12H2,1H3,(H,24,25) CPMIFUXVCIPTKD-UHFFFAOYSA-N 353697 2-[1-(azetidin-1-ylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 929 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353697&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897397 386047430 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697066 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N1CC(C1)C#N InChI=1S/C23H22FN5O3S/c1-32-22-3-2-17(24)10-19(22)18-4-7-26-23-20(18)11-21(27-23)16-5-8-28(9-6-16)33(30,31)29-13-15(12-25)14-29/h2-5,7,10-11,15H,6,8-9,13-14H2,1H3,(H,26,27) ZSHHAMGMDRQAOZ-UHFFFAOYSA-N 353698 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)azetidine-3-carbonitrile::US9796708, Example 930 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353698&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420593 386047431 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697067 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N1CCC(F)(F)CC1 InChI=1S/C24H25F3N4O3S/c1-34-22-3-2-17(25)14-19(22)18-4-9-28-23-20(18)15-21(29-23)16-5-10-30(11-6-16)35(32,33)31-12-7-24(26,27)8-13-31/h2-5,9,14-15H,6-8,10-13H2,1H3,(H,28,29) ZFFSUHJXCULWFC-UHFFFAOYSA-N 353699 2-{1-[(4,4-difluoropiperidin-1-yl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 931 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 510 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353699&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897414 386047432 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697068 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)Nc1cnn(CCS(C)(=O)=O)c1 353700 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{1-[2-(methylsulfonyl)ethyl]-1H-pyrazol-4-yl}cyclohex-3-ene-1-carboxamide::US9796708, Example 932 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353700&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420401 386047433 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697069 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)Nc1cnn(C)c1 353701 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(1-methyl-1H-pyrazol-4-yl)cyclohex-3-ene-1-carboxamide::US9796708, Example 933 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353701&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420032 386047434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697070 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NCc1nnn[nH]1 353702 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(1H-tetrazol-5-ylmethyl)cyclohex-3-ene-1-carboxamide::US9796708, Example 934 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353702&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420791 386047435 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697071 CCC[C@H](NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)C(O)=O InChI=1S/C25H28FN3O3/c1-3-4-21(25(30)31)28-17-8-5-15(6-9-17)22-14-20-18(11-12-27-24(20)29-22)19-13-16(26)7-10-23(19)32-2/h5,7,10-14,17,21,28H,3-4,6,8-9H2,1-2H3,(H,27,29)(H,30,31)/t17?,21-/m0/s1 RCKWALYYSMVPHE-LFABVHOISA-N 353703 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-norvaline::US9796708, Example 935 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353703&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420321 386047436 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697072 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NCc1nnn[nH]1 353704 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(1H-tetrazol-5-ylmethyl)cyclohex-3-en-1-amine::US9796708, Example 936 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353704&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420297 386047437 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697073 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C28H34FN5O4S/c1-32(2)27(35)18-33-12-9-21(10-13-33)39(36,37)34-14-7-19(8-15-34)25-17-24-22(6-11-30-28(24)31-25)23-16-20(29)4-5-26(23)38-3/h4-7,11,16-17,21H,8-10,12-15,18H2,1-3H3,(H,30,31) MMRULQRKGYVRRE-UHFFFAOYSA-N 353705 2-[4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)piperidin-1-yl]-N,N-dimethylacetamide::US9796708, Example 937 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353705&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421475 386047438 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697074 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@@H]2CO)CC1 InChI=1S/C26H29FN4O3/c1-34-24-5-4-18(27)13-21(24)20-6-9-28-26-22(20)14-23(29-26)17-7-11-30(12-8-17)15-25(33)31-10-2-3-19(31)16-32/h4-7,9,13-14,19,32H,2-3,8,10-12,15-16H2,1H3,(H,28,29)/t19-/m1/s1 JLTPEPZBLJDIDW-LJQANCHMSA-N 353706 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 938 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353706&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421314 386047439 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697075 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-28-20-6-5-15(22)12-17(20)16-7-9-23-21-18(16)13-19(24-21)14-4-3-10-25(11-8-14)29(2,26)27/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,23,24) LFCHDVBWVGMFRB-UHFFFAOYSA-N 353707 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-2,3,6,7-tetrahydro-1H-azepin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 939 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353707&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420937 386047440 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697076 CNC(=O)N1CCC=C(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O2/c1-24-22(28)27-10-3-4-14(8-11-27)19-13-18-16(7-9-25-21(18)26-19)17-12-15(23)5-6-20(17)29-2/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,24,28)(H,25,26) CXAUQBJRBRMWQW-UHFFFAOYSA-N 353708 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-2,3,6,7-tetrahydro-1H-azepine-1-carboxamide::US9796708, Example 940 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353708&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420506 386047441 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697077 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N1CCC(=CC1)B(O)O InChI=1S/C25H26BFN4O4/c1-35-23-3-2-18(27)14-20(23)19-4-9-28-24-21(19)15-22(29-24)16-5-10-30(11-6-16)25(32)31-12-7-17(8-13-31)26(33)34/h2-5,7,9,14-15,33-34H,6,8,10-13H2,1H3,(H,28,29) OGKDJEYLEQXPLN-UHFFFAOYSA-N 353709 US9796708, Example 941::[1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)-1,2,3,6-tetrahydropyridin-4-yl]boronic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353709&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419507 386047442 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697078 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(SC)c(=O)c1=O InChI=1S/C24H20FN3O3S/c1-31-19-4-3-14(25)11-16(19)15-5-8-26-24-17(15)12-18(27-24)13-6-9-28(10-7-13)20-21(29)22(30)23(20)32-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,26,27) MBFTZYJSYXPSKX-UHFFFAOYSA-N 353710 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-4-(methylsulfanyl)cyclobut-3-ene-1,2-dione::US9796708, Example 942 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353710&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208145 386047443 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697079 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NS(C)(=O)=O 353711 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}methanesulfonamide::US9796708, Example 943 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353711&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897486 386047444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697080 CNC(=O)NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1O 353712 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-3-methylurea::US9796708, Example 944 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353712&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208146 386047445 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697081 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NC(=O)CO 353713 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-2-hydroxyacetamide::US9796708, Example 945 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353713&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419996 386047446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697082 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NC(=O)CC#N 353714 2-cyano-N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}acetamide::US9796708, Example 946 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353714&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897263 386047447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697083 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C(CNCC1)C#N InChI=1S/C20H17FN4O/c1-26-19-3-2-13(21)8-16(19)15-5-7-24-20-17(15)9-18(25-20)14-4-6-23-11-12(14)10-22/h2-3,5,7-9,23H,4,6,11H2,1H3,(H,24,25) RKJOOTARWWBSQH-UHFFFAOYSA-N 353715 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,5,6-tetrahydropyridine-3-carbonitrile::US9796708, Example 947 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353715&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419564 386047448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697084 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1(CC#N)COC1 InChI=1S/C24H23FN4O2/c1-30-22-3-2-17(25)12-19(22)18-4-9-27-23-20(18)13-21(28-23)16-5-10-29(11-6-16)24(7-8-26)14-31-15-24/h2-5,9,12-13H,6-7,10-11,14-15H2,1H3,(H,27,28) OVJYIGWSASWHRU-UHFFFAOYSA-N 353716 (3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}oxetan-3-yl)acetonitrile::US9796708, Example 948 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353716&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420608 386047449 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697085 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)Nc1cnn(C[C@@H](C)O)c1 InChI=1S/C27H28FN5O3/c1-16(34)14-33-15-20(13-30-33)31-27(35)18-5-3-17(4-6-18)24-12-23-21(9-10-29-26(23)32-24)22-11-19(28)7-8-25(22)36-2/h3,7-13,15-16,18,34H,4-6,14H2,1-2H3,(H,29,32)(H,31,35)/t16-,18?/m1/s1 MMXDAUDRYPJSRM-PYUWXLGESA-N 353717 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{1-[(2R)-2-hydroxypropyl]-1H-pyrazol-4-yl}cyclohex-3-ene-1-carboxamide::US9796708, Example 949 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353717&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419675 386047450 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697086 COC1CN(C1)C(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1O InChI=1S/C24H27FN4O3/c1-32-17-12-29(13-17)23(31)14-28-8-5-15(6-9-28)21-11-20-18(4-7-26-24(20)27-21)19-10-16(25)2-3-22(19)30/h2-4,7,10-11,15,17,30H,5-6,8-9,12-14H2,1H3,(H,26,27) IMVGISYMFJDMNT-UHFFFAOYSA-N 353718 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-(3-methoxyazetidin-1-yl)ethanone::US9796708, Example 950 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353718&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208147 386047451 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697087 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(C2)C#N)CC1 InChI=1S/C25H26FN5O2/c1-33-23-3-2-18(26)10-20(23)19-4-7-28-25-21(19)11-22(29-25)17-5-8-30(9-6-17)15-24(32)31-13-16(12-27)14-31/h2-4,7,10-11,16-17H,5-6,8-9,13-15H2,1H3,(H,28,29) QQWIKVPOOUGAEI-UHFFFAOYSA-N 353719 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetyl)azetidine-3-carbonitrile::US9796708, Example 951 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353719&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419736 386047452 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697088 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(F)(F)C2)CC1 InChI=1S/C24H25F3N4O2/c1-33-21-3-2-16(25)10-18(21)17-4-7-28-23-19(17)11-20(29-23)15-5-8-30(9-6-15)12-22(32)31-13-24(26,27)14-31/h2-4,7,10-11,15H,5-6,8-9,12-14H2,1H3,(H,28,29) HTWXMLHZGLZUTM-UHFFFAOYSA-N 353720 1-(3,3-difluoroazetidin-1-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 952 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353720&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897418 386047453 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697089 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(C)(O)C2)CC1 InChI=1S/C25H29FN4O3/c1-25(32)14-30(15-25)23(31)13-29-9-6-16(7-10-29)21-12-20-18(5-8-27-24(20)28-21)19-11-17(26)3-4-22(19)33-2/h3-5,8,11-12,16,32H,6-7,9-10,13-15H2,1-2H3,(H,27,28) OHDPFAUHKDNVAW-UHFFFAOYSA-N 353721 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-(3-hydroxy-3-methylazetidin-1-yl)ethanone::US9796708, Example 953 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353721&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420558 386047454 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697090 CC[C@@H]1CN([C@@H]1CO)C(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H33FN4O3/c1-3-17-14-32(24(17)16-33)26(34)15-31-10-7-18(8-11-31)23-13-22-20(6-9-29-27(22)30-23)21-12-19(28)4-5-25(21)35-2/h4-6,9,12-13,17-18,24,33H,3,7-8,10-11,14-16H2,1-2H3,(H,29,30)/t17-,24-/m1/s1 XJKODEFKRNCARZ-MZNJEOGPSA-N 353722 1-[(2S,3R)-3-ethyl-2-(hydroxymethyl)azetidin-1-yl]-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 954 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353722&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897390 386047455 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697091 COCC1(C)CN(C1)C(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H33FN4O3/c1-27(17-34-2)15-32(16-27)25(33)14-31-10-7-18(8-11-31)23-13-22-20(6-9-29-26(22)30-23)21-12-19(28)4-5-24(21)35-3/h4-6,9,12-13,18H,7-8,10-11,14-17H2,1-3H3,(H,29,30) MWXYLFSNHVDFEY-UHFFFAOYSA-N 353723 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-[3-(methoxymethyl)-3-methylazetidin-1-yl]ethanone::US9796708, Example 955 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353723&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419825 386047456 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697092 COCC1(F)CCN(C1)C(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353724 1-[3-fluoro-3-(methoxymethyl)pyrrolidin-1-yl]-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 956 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353724&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897433 386047457 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697093 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(F)C2)CC1 InChI=1S/C24H26F2N4O2/c1-32-22-3-2-16(25)10-19(22)18-4-7-27-24-20(18)11-21(28-24)15-5-8-29(9-6-15)14-23(31)30-12-17(26)13-30/h2-4,7,10-11,15,17H,5-6,8-9,12-14H2,1H3,(H,27,28) LCTYLHBKFDJDCA-UHFFFAOYSA-N 353725 1-(3-fluoroazetidin-1-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 957 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353725&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897462 386047458 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697094 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)NC2CC(F)C2)CC1 InChI=1S/C25H28F2N4O2/c1-33-23-3-2-16(26)12-20(23)19-4-7-28-25-21(19)13-22(30-25)15-5-8-31(9-6-15)14-24(32)29-18-10-17(27)11-18/h2-4,7,12-13,15,17-18H,5-6,8-11,14H2,1H3,(H,28,30)(H,29,32) VIERWBWSFAXYKI-UHFFFAOYSA-N 353726 N-(3-fluorocyclobutyl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetamide::US9796708, Example 958 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353726&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420834 386047459 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697095 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC(O)C2)CC1 353727 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-(3-hydroxypyrrolidin-1-yl)ethanone::US9796708, Example 959 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353727&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419701 386047460 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697096 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1(CC(O)=O)COC1 InChI=1S/C24H24FN3O4/c1-31-21-3-2-16(25)10-18(21)17-4-7-26-23-19(17)11-20(27-23)15-5-8-28(9-6-15)24(12-22(29)30)13-32-14-24/h2-5,7,10-11H,6,8-9,12-14H2,1H3,(H,26,27)(H,29,30) OAUHWYFYRYDBFR-UHFFFAOYSA-N 353728 (3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}oxetan-3-yl)acetic acid::US9796708, Example 960 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353728&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420815 386047461 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697097 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1N InChI=1S/C19H19FN4O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-16-14(4-7-22-19(16)23-18)15-10-13(20)2-3-17(15)21/h2-5,7,10-11H,6,8-9,21H2,1H3,(H,22,23) YLPCUGASTIBOQQ-UHFFFAOYSA-N 353729 4-fluoro-2-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 961 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353729&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118274412 386047462 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697098 COC(=O)[C@@H](NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)C(C)(C)C InChI=1S/C27H32FN3O3/c1-27(2,3)24(26(32)34-5)30-18-9-6-16(7-10-18)22-15-21-19(12-13-29-25(21)31-22)20-14-17(28)8-11-23(20)33-4/h6,8,11-15,18,24,30H,7,9-10H2,1-5H3,(H,29,31)/t18?,24-/m1/s1 YSTIHFBMISMWMY-VCUSLETLSA-N 353730 US9796708, Example 962::methyl N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-3-methyl-L-valinate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 480 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353730&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420251 386047463 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696251 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC2CCCOC2)C1 167628 US9073922, 114::US9796708, Example 114 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167628&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412744 312321473 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696252 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCNC(=O)OC(C)(C)C)C1 167629 US9073922, 115::US9796708, Example 115 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167629&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118704726 312321474 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696253 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(C1)C1CCN(C1)C(=O)OC(C)(C)C 167630 US9073922, 116::US9796708, Example 116 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167630&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412414 312321475 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696254 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC2CCOCC2)C1 167631 US9073922, 117::US9796708, Example 117 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167631&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412853 312321476 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696255 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCN2CCOCC2)C1 167632 US9073922, 118::US9796708, Example 118 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167632&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412794 312321477 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696256 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O3S/c1-27-19-4-3-14(21)11-16(19)15-5-8-22-20-17(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) SRPJBGDXQQBRRD-UHFFFAOYSA-N 167633 US9073922, 119::US9796708, Example 119 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167633&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412625 312321478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696257 COC(=O)CCCN[C@H]1CC[C@@H](CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H30FN3O3/c1-31-23-10-7-17(26)14-20(23)19-11-13-28-25-21(19)15-22(29-25)16-5-8-18(9-6-16)27-12-3-4-24(30)32-2/h7,10-11,13-16,18,27H,3-6,8-9,12H2,1-2H3,(H,28,29)/t16-,18- ZXOSDMFXEYCJNH-SAABIXHNSA-N 167634 US9073922, 120::US9796708, Example 120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167634&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413985 312321479 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696258 CCOC(=O)C1CC1CN[C@H]1CC[C@@H](CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H32FN3O3/c1-3-34-27(32)21-12-17(21)15-30-19-7-4-16(5-8-19)24-14-23-20(10-11-29-26(23)31-24)22-13-18(28)6-9-25(22)33-2/h6,9-11,13-14,16-17,19,21,30H,3-5,7-8,12,15H2,1-2H3,(H,29,31)/t16-,17?,19-,21? DVVNHXOEAPZNNY-LWAMJLSBSA-N 167635 US9073922, 121::US9796708, Example 121 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167635&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412910 312321480 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696259 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CC[C@@H](CC1)NCCN1CCOCC1 351830 US9796708, Example 122::trans-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]cyclohexanamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351830&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413999 386046239 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696260 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CC[C@@H](CC1)NCC(O)CO InChI=1S/C23H28FN3O3/c1-30-22-7-4-15(24)10-19(22)18-8-9-25-23-20(18)11-21(27-23)14-2-5-16(6-3-14)26-12-17(29)13-28/h4,7-11,14,16-17,26,28-29H,2-3,5-6,12-13H2,1H3,(H,25,27)/t14-,16-,17? CZLVXOCWXJLMQW-SYPQHRIQSA-N 167636 US9073922, 123::US9796708, Example 123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167636&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412932 312321481 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696261 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCN)C1 167637 US9073922, 124::US9796708, Example 124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167637&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412926 312321482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696262 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(C1)C1CCNC1 167638 US9073922, 125::US9796708, Example 125 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167638&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411647 312321483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696263 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CCNCC1 InChI=1S/C19H20FN3O2/c1-25-16-3-2-12(20)10-14(16)13-4-7-22-18-15(13)11-17(23-18)19(24)5-8-21-9-6-19/h2-4,7,10-11,21,24H,5-6,8-9H2,1H3,(H,22,23) DGWKMZJFPLZNFJ-UHFFFAOYSA-N 167639 US9073922, 126::US9796708, Example 126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167639&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413153 312321484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696264 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(CCCNC(=O)OCc2ccccc2)C1 167640 US9073922, 127::US9796708, Example 127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167640&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118704727 312321485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696265 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(CCO)C1 167641 US9073922, 128::US9796708, Example 128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167641&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412418 312321486 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696266 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(CCCN)C1 167642 US9073922, 129::US9796708, Example 129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167642&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412574 312321487 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696267 COCCN1CCCC(C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 167643 US9073922, 130::US9796708, Example 130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167643&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412563 312321488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696268 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CC[C@@H](CC1)NCCCC(O)=O InChI=1S/C24H28FN3O3/c1-31-22-9-6-16(25)13-19(22)18-10-12-27-24-20(18)14-21(28-24)15-4-7-17(8-5-15)26-11-2-3-23(29)30/h6,9-10,12-15,17,26H,2-5,7-8,11H2,1H3,(H,27,28)(H,29,30)/t15-,17- QRJCAHPPWSSSME-JCNLHEQBSA-N 167644 US9073922, 131::US9796708, Example 131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167644&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411609 312321489 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696269 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(N)ccc1Cl InChI=1S/C18H20ClN5/c1-24-8-5-11(6-9-24)15-10-13-12(4-7-21-18(13)22-15)17-14(19)2-3-16(20)23-17/h2-4,7,10-11H,5-6,8-9H2,1H3,(H2,20,23)(H,21,22) NMOFSJVEPFAGLJ-UHFFFAOYSA-N 167645 US9073922, 132::US9796708, Example 132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167645&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292825 312321490 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696270 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(Nc2nc(N)ccc2Cl)ccc1Cl InChI=1S/C23H23Cl2N7/c1-32-10-7-13(8-11-32)18-12-15-14(6-9-27-22(15)28-18)21-16(24)3-5-20(30-21)31-23-17(25)2-4-19(26)29-23/h2-6,9,12-13H,7-8,10-11H2,1H3,(H,27,28)(H3,26,29,30,31) KVFFQMRFWHQOQX-UHFFFAOYSA-N 167646 US9073922, 133::US9796708, Example 133 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167646&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292824 312321491 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696271 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCOCC2)ccc1Cl InChI=1S/C24H30ClN5O/c1-30-10-5-17(6-11-30)21-14-19-18(4-9-26-24(19)28-21)23-20(25)2-3-22(29-23)27-15-16-7-12-31-13-8-16/h2-4,9,14,16-17H,5-8,10-13,15H2,1H3,(H,26,28)(H,27,29) RZWWKCQREWTJSE-UHFFFAOYSA-N 167647 US9073922, 134::US9796708, Example 134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167647&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292827 312321492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696272 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(C)=O InChI=1S/C21H22FN3O2/c1-13(26)25-9-6-14(7-10-25)19-12-18-16(5-8-23-21(18)24-19)17-11-15(22)3-4-20(17)27-2/h3-5,8,11-12,14H,6-7,9-10H2,1-2H3,(H,23,24) WBXXHYPWIWFDON-UHFFFAOYSA-N 167648 US9073922, 135::US9796708, Example 135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167648&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413045 312321493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696273 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CO InChI=1S/C21H22FN3O3/c1-28-19-3-2-14(22)10-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)20(27)12-26/h2-4,7,10-11,13,26H,5-6,8-9,12H2,1H3,(H,23,24) OUWYPSQWPFNDDW-UHFFFAOYSA-N 167649 US9073922, 136::US9796708, Example 136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167649&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414453 312321494 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696274 COc1cc(ccc1-c1ccnc2[nH]c(cc12)C1CCCNC1)C#N 167650 US9073922, 137::US9796708, Example 137 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167650&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412514 312321495 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696275 C(Cc1ccccc1)Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H27N5/c1-2-5-18(6-3-1)9-15-27-24-8-4-7-22(29-24)20-12-16-28-25-21(20)17-23(30-25)19-10-13-26-14-11-19/h1-8,12,16-17,19,26H,9-11,13-15H2,(H,27,29)(H,28,30) SOUOCRDJFLDYDD-UHFFFAOYSA-N 167651 US9073922, 138::US9796708, Example 138 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167651&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292826 312321496 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696276 CN(CCc1ccccc1)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C27H31N5/c1-31-16-13-21(14-17-31)25-19-23-22(11-15-28-27(23)30-25)24-9-6-10-26(29-24)32(2)18-12-20-7-4-3-5-8-20/h3-11,15,19,21H,12-14,16-18H2,1-2H3,(H,28,30) RVYGOLVPRWYBBS-UHFFFAOYSA-N 167652 US9073922, 139::US9796708, Example 140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167652&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292828 312321497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696277 CN(CCc1ccccc1)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C27H31N5/c1-31-16-13-21(14-17-31)25-19-23-22(11-15-28-27(23)30-25)24-9-6-10-26(29-24)32(2)18-12-20-7-4-3-5-8-20/h3-11,15,19,21H,12-14,16-18H2,1-2H3,(H,28,30) RVYGOLVPRWYBBS-UHFFFAOYSA-N 167652 US9073922, 139::US9796708, Example 140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167652&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86292828 312321497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696278 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2ccccc2Cl)n1 InChI=1S/C25H26ClN5/c1-31-13-10-17(11-14-31)23-15-20-19(9-12-27-25(20)30-23)22-7-4-8-24(29-22)28-16-18-5-2-3-6-21(18)26/h2-9,12,15,17H,10-11,13-14,16H2,1H3,(H,27,30)(H,28,29) AHPCMYGDRQWMRV-UHFFFAOYSA-N 167654 US9073922, 141::US9796708, Example 141 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167654&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86293012 312321499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696279 CN(Cc1ccccc1Cl)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C26H28ClN5/c1-31-14-11-18(12-15-31)24-16-21-20(10-13-28-26(21)30-24)23-8-5-9-25(29-23)32(2)17-19-6-3-4-7-22(19)27/h3-10,13,16,18H,11-12,14-15,17H2,1-2H3,(H,28,30) CYXDJKHUFFAPKC-UHFFFAOYSA-N 167655 US9073922, 142::US9796708, Example 142 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86293013 312321500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696280 O=C1CCCN1CCNc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C23H28N6O/c30-22-5-2-13-29(22)14-12-25-21-4-1-3-19(27-21)17-8-11-26-23-18(17)15-20(28-23)16-6-9-24-10-7-16/h1,3-4,8,11,15-16,24H,2,5-7,9-10,12-14H2,(H,25,27)(H,26,28) WHXJBIWHSJCFCG-UHFFFAOYSA-N 167656 US9073922, 143::US9796708, Example 143 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167656&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412038 312321501 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696281 CN(CCN1CCCC1=O)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1 InChI=1S/C25H32N6O/c1-29-13-9-18(10-14-29)22-17-20-19(8-11-26-25(20)28-22)21-5-3-6-23(27-21)30(2)15-16-31-12-4-7-24(31)32/h3,5-6,8,11,17-18H,4,7,9-10,12-16H2,1-2H3,(H,26,28) BBRUVYBRRVBIJX-UHFFFAOYSA-N 167657 US9073922, 144::US9796708, Example 144 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 370 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167657&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411973 312321502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696282 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)[C@H]1CC[C@@H](CC1)NCC1CC1C(O)=O InChI=1S/C25H28FN3O3/c1-32-23-7-4-16(26)11-20(23)18-8-9-27-24-21(18)12-22(29-24)14-2-5-17(6-3-14)28-13-15-10-19(15)25(30)31/h4,7-9,11-12,14-15,17,19,28H,2-3,5-6,10,13H2,1H3,(H,27,29)(H,30,31)/t14-,15?,17-,19? CEWUZDSTHUFKMS-KUCRQJOESA-N 167658 US9073922, 145::US9796708, Example 145 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167658&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412535 312321503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696283 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CNC1 InChI=1S/C17H16FN3O/c1-22-16-3-2-11(18)6-13(16)12-4-5-20-17-14(12)7-15(21-17)10-8-19-9-10/h2-7,10,19H,8-9H2,1H3,(H,20,21) JXMXWTSNIZWTAA-UHFFFAOYSA-N 167659 US9073922, 146::US9796708, Example 146 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167659&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414002 312321504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696284 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CN1CCC(O)CC1 InChI=1S/C26H31FN4O3/c1-34-24-3-2-18(27)14-21(24)20-4-9-28-26-22(20)15-23(29-26)17-5-12-31(13-6-17)25(33)16-30-10-7-19(32)8-11-30/h2-4,9,14-15,17,19,32H,5-8,10-13,16H2,1H3,(H,28,29) WVSZDXZJJGEONZ-UHFFFAOYSA-N 167660 US9073922, 147::US9796708, Example 147 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167660&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412807 312321505 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696285 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(C)(=O)=O InChI=1S/C20H22FN3O3S/c1-27-19-4-3-14(21)11-16(19)15-5-8-22-20-17(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-5,8,11-13H,6-7,9-10H2,1-2H3,(H,22,23) CEFCSVVSBXHZEW-UHFFFAOYSA-N 167661 US9073922, 148::US9796708, Example 148 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167661&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414321 312321506 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696286 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(O)CO)CC1 167662 US9073922, 149::US9796708, Example 149 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167662&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412005 312321507 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696287 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCc2ccccc2)n1 InChI=1S/C26H29N5/c1-31-16-12-20(13-17-31)24-18-22-21(11-15-28-26(22)30-24)23-8-5-9-25(29-23)27-14-10-19-6-3-2-4-7-19/h2-9,11,15,18,20H,10,12-14,16-17H2,1H3,(H,27,29)(H,28,30) MXYFERHGZLMTPI-UHFFFAOYSA-N 167663 US9073922, 150::US9796708, Example 150 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167663&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412544 312321508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696288 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCN2CCCC2=O)n1 InChI=1S/C24H30N6O/c1-29-13-8-17(9-14-29)21-16-19-18(7-10-26-24(19)28-21)20-4-2-5-22(27-20)25-11-15-30-12-3-6-23(30)31/h2,4-5,7,10,16-17H,3,6,8-9,11-15H2,1H3,(H,25,27)(H,26,28) BSUPEIKXZJIVQF-UHFFFAOYSA-N 167664 US9073922, 151::US9796708, Example 151 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167664&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411211 312321509 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696289 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CC2)ccc1Cl InChI=1S/C22H26ClN5/c1-28-10-7-15(8-11-28)19-12-17-16(6-9-24-22(17)26-19)21-18(23)4-5-20(27-21)25-13-14-2-3-14/h4-6,9,12,14-15H,2-3,7-8,10-11,13H2,1H3,(H,24,26)(H,25,27) OYXOGYQPUARIKH-UHFFFAOYSA-N 167665 US9073922, 152::US9796708, Example 152 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167665&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411958 312321510 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696290 CN(C)CCOc1ccc(CNc2cccc(n2)-c2ccnc3[nH]c(cc23)C2CCN(C)CC2)cc1 InChI=1S/C29H36N6O/c1-34(2)17-18-36-23-9-7-21(8-10-23)20-31-28-6-4-5-26(32-28)24-11-14-30-29-25(24)19-27(33-29)22-12-15-35(3)16-13-22/h4-11,14,19,22H,12-13,15-18,20H2,1-3H3,(H,30,33)(H,31,32) NMGPVXUDQOOKEY-UHFFFAOYSA-N 167666 US9073922, 153::US9796708, Example 153 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167666&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411123 312321511 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696291 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCOC(C)(C)C2)ccc1Cl 167667 US9073922, 154::US9796708, Example 154 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167667&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413100 312321512 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696292 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccncc2)ccc1Cl InChI=1S/C24H25ClN6/c1-31-12-7-17(8-13-31)21-14-19-18(6-11-27-24(19)29-21)23-20(25)2-3-22(30-23)28-15-16-4-9-26-10-5-16/h2-6,9-11,14,17H,7-8,12-13,15H2,1H3,(H,27,29)(H,28,30) JSJOGCJKTLAUML-UHFFFAOYSA-N 167668 US9073922, 155::US9796708, Example 155 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167668&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412431 312321513 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696293 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cc[nH]n2)n1 InChI=1S/C22H25N7/c1-29-11-7-15(8-12-29)20-13-18-17(6-9-23-22(18)27-20)19-3-2-4-21(26-19)24-14-16-5-10-25-28-16/h2-6,9-10,13,15H,7-8,11-12,14H2,1H3,(H,23,27)(H,24,26)(H,25,28) FIOUSIQCBJHCSJ-UHFFFAOYSA-N 167669 US9073922, 156::US9796708, Example 156 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167669&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118704728 312321514 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696294 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2ccc3CNCc3c2)n1 InChI=1S/C27H30N6/c1-33-11-8-19(9-12-33)25-14-23-22(7-10-29-27(23)32-25)24-3-2-4-26(31-24)30-15-18-5-6-20-16-28-17-21(20)13-18/h2-7,10,13-14,19,28H,8-9,11-12,15-17H2,1H3,(H,29,32)(H,30,31) NJHSGSHGPDTPRW-UHFFFAOYSA-N 167670 US9073922, 157::US9796708, Example 157 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167670&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411689 312321515 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696295 CN1CCC(CNc2cccc(n2)-c2ccnc3[nH]c(cc23)C2CCN(C)CC2)C1 167671 US9073922, 158::US9796708, Example 158 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167671&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413707 312321516 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696296 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2ccc3cc[nH]c3c2)n1 InChI=1S/C27H28N6/c1-33-13-9-20(10-14-33)25-16-22-21(8-12-29-27(22)32-25)23-3-2-4-26(31-23)30-17-18-5-6-19-7-11-28-24(19)15-18/h2-8,11-12,15-16,20,28H,9-10,13-14,17H2,1H3,(H,29,32)(H,30,31) CQHUGJJRGFRCBL-UHFFFAOYSA-N 167672 US9073922, 159::US9796708, Example 159 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167672&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412336 312321517 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696297 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccc(cc2)S(C)(=O)=O)ccc1Cl InChI=1S/C26H28ClN5O2S/c1-32-13-10-18(11-14-32)23-15-21-20(9-12-28-26(21)30-23)25-22(27)7-8-24(31-25)29-16-17-3-5-19(6-4-17)35(2,33)34/h3-9,12,15,18H,10-11,13-14,16H2,1-2H3,(H,28,30)(H,29,31) AALRKJZOMLZXEH-UHFFFAOYSA-N 167673 US9073922, 160::US9796708, Example 160 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167673&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412513 312321518 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696298 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccc(cc2)S(N)(=O)=O)ccc1Cl InChI=1S/C25H27ClN6O2S/c1-32-12-9-17(10-13-32)22-14-20-19(8-11-28-25(20)30-22)24-21(26)6-7-23(31-24)29-15-16-2-4-18(5-3-16)35(27,33)34/h2-8,11,14,17H,9-10,12-13,15H2,1H3,(H,28,30)(H,29,31)(H2,27,33,34) ZHYLQSOHBJWQEA-UHFFFAOYSA-N 167674 US9073922, 161::US9796708, Example 161 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167674&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411657 312321519 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696299 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccc(cc2)C(N)=O)ccc1Cl InChI=1S/C26H27ClN6O/c1-33-12-9-17(10-13-33)22-14-20-19(8-11-29-26(20)31-22)24-21(27)6-7-23(32-24)30-15-16-2-4-18(5-3-16)25(28)34/h2-8,11,14,17H,9-10,12-13,15H2,1H3,(H2,28,34)(H,29,31)(H,30,32) RQLVQFKZUQEIPL-UHFFFAOYSA-N 167675 US9073922, 162::US9796708, Example 162 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167675&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412402 312321520 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696300 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCN2CCOCC2)n1 InChI=1S/C24H32N6O/c1-29-10-6-18(7-11-29)22-17-20-19(5-8-26-24(20)28-22)21-3-2-4-23(27-21)25-9-12-30-13-15-31-16-14-30/h2-5,8,17-18H,6-7,9-16H2,1H3,(H,25,27)(H,26,28) WPEMVTWLJQSTIG-UHFFFAOYSA-N 167676 US9073922, 163::US9796708, Example 163 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167676&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413063 312321521 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696301 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCO)n1 InChI=1S/C20H25N5O/c1-25-10-6-14(7-11-25)18-13-16-15(5-8-22-20(16)24-18)17-3-2-4-19(23-17)21-9-12-26/h2-5,8,13-14,26H,6-7,9-12H2,1H3,(H,21,23)(H,22,24) RRYYSXNCESRHDH-UHFFFAOYSA-N 167677 US9073922, 164::US9796708, Example 164 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167677&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412300 312321522 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696302 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCNCC2)ccc1Cl InChI=1S/C24H31ClN6/c1-31-12-7-17(8-13-31)21-14-19-18(6-11-27-24(19)29-21)23-20(25)2-3-22(30-23)28-15-16-4-9-26-10-5-16/h2-3,6,11,14,16-17,26H,4-5,7-10,12-13,15H2,1H3,(H,27,29)(H,28,30) JAUDFHALONQPBD-UHFFFAOYSA-N 167678 US9073922, 165::US9796708, Example 165 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167678&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411712 312321523 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696303 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CCOCC1 InChI=1S/C19H19FN2O3/c1-24-16-3-2-12(20)10-14(16)13-4-7-21-18-15(13)11-17(22-18)19(23)5-8-25-9-6-19/h2-4,7,10-11,23H,5-6,8-9H2,1H3,(H,21,22) VLALFVOYKRZFDF-UHFFFAOYSA-N 167679 US9073922, 166::US9796708, Example 166 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167679&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413237 312321524 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697099 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NC#N 353731 N-cyano-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxamide::US9796708, Example 963 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353731&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419506 386047464 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697100 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1(C)C InChI=1S/C21H22FN3O/c1-21(2)12-23-8-7-17(21)18-11-16-14(6-9-24-20(16)25-18)15-10-13(22)4-5-19(15)26-3/h4-7,9-11,23H,8,12H2,1-3H3,(H,24,25) WFTVDCRMPMKSMR-UHFFFAOYSA-N 353732 2-(3,3-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 964 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353732&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420333 386047465 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697101 CNCCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H26FN5O5S/c1-25-9-12-34-23(30)28-35(31,32)29-10-6-15(7-11-29)20-14-19-17(5-8-26-22(19)27-20)18-13-16(24)3-4-21(18)33-2/h3-6,8,13-14,25H,7,9-12H2,1-2H3,(H,26,27)(H,28,30) HKKDTZLYLRCSPR-UHFFFAOYSA-N 353733 2-(methylamino)ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 965 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353733&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420159 386047466 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697102 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCCOC(C)=O InChI=1S/C24H25FN4O7S/c1-15(30)35-11-12-36-24(31)28-37(32,33)29-9-6-16(7-10-29)21-14-20-18(5-8-26-23(20)27-21)19-13-17(25)3-4-22(19)34-2/h3-6,8,13-14H,7,9-12H2,1-2H3,(H,26,27)(H,28,31) WQKJWWPFGYZLQE-UHFFFAOYSA-N 353734 2-{[({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamoyl]oxy}ethyl acetate::US9796708, Example 966 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353734&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897368 386047467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697103 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCCN1CCCC1 InChI=1S/C26H30FN5O5S/c1-36-24-5-4-19(27)16-21(24)20-6-9-28-25-22(20)17-23(29-25)18-7-12-32(13-8-18)38(34,35)30-26(33)37-15-14-31-10-2-3-11-31/h4-7,9,16-17H,2-3,8,10-15H2,1H3,(H,28,29)(H,30,33) LXGFVROSNYCGNO-UHFFFAOYSA-N 353735 2-(pyrrolidin-1-yl)ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 967 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353735&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419557 386047468 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697104 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OC1CNC1 InChI=1S/C23H24FN5O5S/c1-33-21-3-2-15(24)10-18(21)17-4-7-26-22-19(17)11-20(27-22)14-5-8-29(9-6-14)35(31,32)28-23(30)34-16-12-25-13-16/h2-5,7,10-11,16,25H,6,8-9,12-13H2,1H3,(H,26,27)(H,28,30) VJCUVUOUFXIVGS-UHFFFAOYSA-N 353736 US9796708, Example 968::azetidin-3-yl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353736&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420472 386047469 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697105 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCCO InChI=1S/C22H23FN4O6S/c1-32-20-3-2-15(23)12-17(20)16-4-7-24-21-18(16)13-19(25-21)14-5-8-27(9-6-14)34(30,31)26-22(29)33-11-10-28/h2-5,7,12-13,28H,6,8-11H2,1H3,(H,24,25)(H,26,29) BVJPGQMNFJPQHY-UHFFFAOYSA-N 353737 2-hydroxyethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 969 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353737&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420019 386047470 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697106 CS(=O)(=O)NCCOc1cc(F)cc(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H25FN4O5S2/c1-33(28,29)25-7-10-32-18-12-16(11-17(23)13-18)19-3-6-24-22-20(19)14-21(26-22)15-4-8-27(9-5-15)34(2,30)31/h3-4,6,11-14,25H,5,7-10H2,1-2H3,(H,24,26) XGNSLRQKKNUEJL-UHFFFAOYSA-N 353738 N-[2-(3-fluoro-5-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenoxy)ethyl]methanesulfonamide::US9796708, Example 970 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353738&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421075 386047471 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697107 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(=O)NCC1 InChI=1S/C19H16FN3O2/c1-25-17-3-2-12(20)9-14(17)13-5-7-22-19-15(13)10-16(23-19)11-4-6-21-18(24)8-11/h2-3,5,7-10H,4,6H2,1H3,(H,21,24)(H,22,23) GDBFDUPJJUQUPU-UHFFFAOYSA-N 353739 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dihydropyridin-2(1H)-one::US9796708, Example 971 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353739&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420760 386047472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697108 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NC2CC(O)C2)CC1 InChI=1S/C25H27FN4O3/c1-33-23-3-2-16(26)10-20(23)19-4-7-27-25-21(19)13-22(29-25)15-5-8-30(9-6-15)14-24(32)28-17-11-18(31)12-17/h2-5,7,10,13,17-18,31H,6,8-9,11-12,14H2,1H3,(H,27,29)(H,28,32) WMPPWOMBKCGEHH-UHFFFAOYSA-N 353740 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(3-hydroxycyclobutyl)acetamide::US9796708, Example 972 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353740&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897244 386047473 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697109 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC(=O)N1CCCC1CO 353741 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-[2-(hydroxymethyl)pyrrolidin-1-yl]propane-1,3-dione::US9796708, Example 973 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353741&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897399 386047474 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697110 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)NC(C1CC1)C(O)=O 353742 US9796708, Example 974::cyclopropyl({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}amino)acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353742&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419737 386047475 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697111 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1(C)C)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-22(2)13-26(30(4,27)28)10-8-18(22)19-12-17-15(7-9-24-21(17)25-19)16-11-14(23)5-6-20(16)29-3/h5-9,11-12H,10,13H2,1-4H3,(H,24,25) ORMRTHHSFHBYHG-UHFFFAOYSA-N 353743 2-[3,3-dimethyl-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 975 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353743&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897227 386047476 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697112 CNC(=O)N1CC=C(c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)C(C)(C)C1 InChI=1S/C23H25FN4O2/c1-23(2)13-28(22(29)25-3)10-8-18(23)19-12-17-15(7-9-26-21(17)27-19)16-11-14(24)5-6-20(16)30-4/h5-9,11-12H,10,13H2,1-4H3,(H,25,29)(H,26,27) FIFWATDAQAVJAW-UHFFFAOYSA-N 353744 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N,3,3-trimethyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 976 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353744&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420670 386047477 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697113 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(N)CC1 353745 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-amine::US9796708, Example 977 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353745&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414101 386047478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697114 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](C)NCC1 InChI=1S/C20H20FN3O/c1-12-9-13(5-7-22-12)18-11-17-15(6-8-23-20(17)24-18)16-10-14(21)3-4-19(16)25-2/h3-4,6,8-12,22H,5,7H2,1-2H3,(H,23,24)/t12-/m0/s1 WSCONERQESPBQY-LBPRGKRZSA-N 353746 4-(5-fluoro-2-methoxyphenyl)-2-[(6S)-6-methyl-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 978 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353746&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412922 386047479 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697115 CNC(=O)CNc1c(N2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)c(=O)c1=O InChI=1S/C26H24FN5O4/c1-28-21(33)13-30-22-23(25(35)24(22)34)32-9-6-14(7-10-32)19-12-18-16(5-8-29-26(18)31-19)17-11-15(27)3-4-20(17)36-2/h3-6,8,11-12,30H,7,9-10,13H2,1-2H3,(H,28,33)(H,29,31) JDESGEPSWSEFCL-UHFFFAOYSA-N 353747 N2-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3,4-dioxocyclobut-1-en-1-yl)-N-methylglycinamide::US9796708, Example 979 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353747&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208148 386047480 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697116 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(NCC(=O)OC(C)(C)C)c(=O)c1=O InChI=1S/C29H29FN4O5/c1-29(2,3)39-23(35)15-32-24-25(27(37)26(24)36)34-11-8-16(9-12-34)21-14-20-18(7-10-31-28(20)33-21)19-13-17(30)5-6-22(19)38-4/h5-8,10,13-14,32H,9,11-12,15H2,1-4H3,(H,31,33) RGDYQMAQGMIYQR-UHFFFAOYSA-N 353748 US9796708, Example 980::tert-butyl N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3,4-dioxocyclobut-1-en-1-yl)glycinate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353748&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208149 386047481 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697117 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(NCC(N)=O)c(=O)c1=O InChI=1S/C25H22FN5O4/c1-35-19-3-2-14(26)10-16(19)15-4-7-28-25-17(15)11-18(30-25)13-5-8-31(9-6-13)22-21(23(33)24(22)34)29-12-20(27)32/h2-5,7,10-11,29H,6,8-9,12H2,1H3,(H2,27,32)(H,28,30) OGTDXOUJHFJGIP-UHFFFAOYSA-N 353749 N2-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3,4-dioxocyclobut-1-en-1-yl)glycinamide::US9796708, Example 981 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353749&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208150 386047482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697118 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1c(NCC(=O)N(C)C)c(=O)c1=O InChI=1S/C27H26FN5O4/c1-32(2)22(34)14-30-23-24(26(36)25(23)35)33-10-7-15(8-11-33)20-13-19-17(6-9-29-27(19)31-20)18-12-16(28)4-5-21(18)37-3/h4-7,9,12-13,30H,8,10-11,14H2,1-3H3,(H,29,31) NXLCGYCWEREWPT-UHFFFAOYSA-N 353750 N2-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3,4-dioxocyclobut-1-en-1-yl)-N,N-dimethylglycinamide::US9796708, Example 982 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353750&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208151 386047483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697119 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)OC(C)(C)C)CC1 InChI=1S/C25H28FN3O3/c1-25(2,3)32-23(30)15-29-11-8-16(9-12-29)21-14-20-18(7-10-27-24(20)28-21)19-6-5-17(26)13-22(19)31-4/h5-8,10,13-14H,9,11-12,15H2,1-4H3,(H,27,28) XUBOPCGTLNWYMV-UHFFFAOYSA-N 353751 US9796708, Example 983::tert-butyl {4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353751&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208152 386047484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697120 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1(C)C InChI=1S/C23H24FN3O3/c1-23(2)13-27(12-21(28)29)9-7-18(23)19-11-17-15(6-8-25-22(17)26-19)16-10-14(24)4-5-20(16)30-3/h4-8,10-11H,9,12-13H2,1-3H3,(H,25,26)(H,28,29) SPCIXYBQBIMTLY-UHFFFAOYSA-N 353752 US9796708, Example 984::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3-dimethyl-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353752&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897434 386047485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697121 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C#N 353753 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carbonitrile::US9796708, Example 985 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353753&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420329 386047486 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697122 COc1ccc(F)cc1-c1c(OC)cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H27FN4O3/c1-28(2)22(30)14-29-9-7-15(8-10-29)19-12-18-23(21(32-4)13-26-24(18)27-19)17-11-16(25)5-6-20(17)31-3/h5-7,11-13H,8-10,14H2,1-4H3,(H,26,27) UTTYMSLBRBWNNC-UHFFFAOYSA-N 353754 2-{4-[4-(5-fluoro-2-methoxyphenyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 986 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 420 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353754&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897358 386047487 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697123 CCOC(=O)NS(=O)(=O)N1CC2CC(=CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353755 US9796708, Example 987::ethyl ({5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353755&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208153 386047488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697124 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(O)CO)CC2C1 353756 3-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}propane-1,2-diol::US9796708, Example 988 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353756&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421012 386047489 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697125 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(O)=O)CC2C1 353757 US9796708, Example 989::{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}) acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353757&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419779 386047490 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697126 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(N)=O)CC1 InChI=1S/C21H21FN4O2/c1-28-19-10-14(22)2-3-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-26(9-6-13)12-20(23)27/h2-5,7,10-11H,6,8-9,12H2,1H3,(H2,23,27)(H,24,25) LOYSSJWQGSPXBU-UHFFFAOYSA-N 353758 2-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetamide::US9796708, Example 990 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 72.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353758&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897441 386047491 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697127 CNC(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(F)cc1OC InChI=1S/C22H23FN4O2/c1-24-21(28)13-27-9-6-14(7-10-27)19-12-18-16(5-8-25-22(18)26-19)17-4-3-15(23)11-20(17)29-2/h3-6,8,11-12H,7,9-10,13H2,1-2H3,(H,24,28)(H,25,26) LVPFFNZDFMYJGN-UHFFFAOYSA-N 353759 2-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-methylacetamide::US9796708, Example 991 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353759&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420241 386047492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697128 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCC(CC1)N[C@H](C(C)C)C(O)=O InChI=1S/C25H30FN3O3/c1-14(2)23(25(30)31)28-17-7-4-15(5-8-17)21-13-20-18(10-11-27-24(20)29-21)19-12-16(26)6-9-22(19)32-3/h6,9-15,17,23,28H,4-5,7-8H2,1-3H3,(H,27,29)(H,30,31)/t15?,17?,23-/m1/s1 BNAPWWWIUGTDRO-PYDGXCHUSA-N 353760 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohexyl}-D-valine::US9796708, Example 992 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353760&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419890 386047493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697129 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(N)=O)CC1 InChI=1S/C21H22F2N4O2/c1-29-18-3-2-13(22)8-14(18)20-15-9-17(26-21(15)25-10-16(20)23)12-4-6-27(7-5-12)11-19(24)28/h2-3,8-10,12H,4-7,11H2,1H3,(H2,24,28)(H,25,26) BVWZOXXLGVLMGG-UHFFFAOYSA-N 353761 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetamide::US9796708, Example 993 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353761&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897312 386047494 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697130 COCCOCCN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C24H28FN3O3/c1-29-13-14-31-12-11-28-9-6-17(7-10-28)22-16-21-19(5-8-26-24(21)27-22)20-15-18(25)3-4-23(20)30-2/h3-6,8,15-16H,7,9-14H2,1-2H3,(H,26,27) MZYXJSWGUQMEGJ-UHFFFAOYSA-N 353762 4-(5-fluoro-2-methoxyphenyl)-2-{1-[2-(2-methoxyethoxy)ethyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 994 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353762&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897238 386047495 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697131 CNS(=O)(=O)OC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353763 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl methylsulfamate::US9796708, Example 995 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353763&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897200 386047496 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697132 COC1CN(C1)C(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H27FN4O3/c1-32-18-13-30(14-18)24(31)15-29-9-6-16(7-10-29)22-12-21-19(5-8-27-25(21)28-22)20-11-17(26)3-4-23(20)33-2/h3-6,8,11-12,18H,7,9-10,13-15H2,1-2H3,(H,27,28) JEKSLFYLKVSAQJ-UHFFFAOYSA-N 353764 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(3-methoxyazetidin-1-yl)ethanone::US9796708, Example 996 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353764&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421050 386047497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697133 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(C2)C#N)CC1 InChI=1S/C25H24FN5O2/c1-33-23-3-2-18(26)10-20(23)19-4-7-28-25-21(19)11-22(29-25)17-5-8-30(9-6-17)15-24(32)31-13-16(12-27)14-31/h2-5,7,10-11,16H,6,8-9,13-15H2,1H3,(H,28,29) MZCNHIFSTQCXMN-UHFFFAOYSA-N 353765 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetyl)azetidine-3-carbonitrile::US9796708, Example 997 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353765&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420182 386047498 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697134 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(F)(F)C2)CC1 InChI=1S/C24H23F3N4O2/c1-33-21-3-2-16(25)10-18(21)17-4-7-28-23-19(17)11-20(29-23)15-5-8-30(9-6-15)12-22(32)31-13-24(26,27)14-31/h2-5,7,10-11H,6,8-9,12-14H2,1H3,(H,28,29) MGNSYXANBPGFNP-UHFFFAOYSA-N 353766 1-(3,3-difluoroazetidin-1-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 998 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353766&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897479 386047499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697135 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(CO)C2)CC1 InChI=1S/C25H27FN4O3/c1-33-23-3-2-18(26)10-20(23)19-4-7-27-25-21(19)11-22(28-25)17-5-8-29(9-6-17)14-24(32)30-12-16(13-30)15-31/h2-5,7,10-11,16,31H,6,8-9,12-15H2,1H3,(H,27,28) ABAHFFAFDXIWSH-UHFFFAOYSA-N 353767 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[3-(hydroxymethyl)azetidin-1-yl]ethanone::US9796708, Example 999 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353767&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897484 386047500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697136 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(C)(O)C2)CC1 InChI=1S/C25H27FN4O3/c1-25(32)14-30(15-25)23(31)13-29-9-6-16(7-10-29)21-12-20-18(5-8-27-24(20)28-21)19-11-17(26)3-4-22(19)33-2/h3-6,8,11-12,32H,7,9-10,13-15H2,1-2H3,(H,27,28) MAUDGCGDSJAZTE-UHFFFAOYSA-N 353768 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(3-hydroxy-3-methylazetidin-1-yl)ethanone::US9796708, Example 1000 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353768&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420458 386047501 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697137 CC[C@@H]1CN([C@@H]1CO)C(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H31FN4O3/c1-3-17-14-32(24(17)16-33)26(34)15-31-10-7-18(8-11-31)23-13-22-20(6-9-29-27(22)30-23)21-12-19(28)4-5-25(21)35-2/h4-7,9,12-13,17,24,33H,3,8,10-11,14-16H2,1-2H3,(H,29,30)/t17-,24-/m1/s1 PHCGJYGESLXPLQ-MZNJEOGPSA-N 353769 1-[(2S,3R)-3-ethyl-2-(hydroxymethyl)azetidin-1-yl]-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 1001 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353769&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897229 386047502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697138 COCC1(C)CN(C1)C(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H31FN4O3/c1-27(17-34-2)15-32(16-27)25(33)14-31-10-7-18(8-11-31)23-13-22-20(6-9-29-26(22)30-23)21-12-19(28)4-5-24(21)35-3/h4-7,9,12-13H,8,10-11,14-17H2,1-3H3,(H,29,30) NPGJVTMVTUHZRG-UHFFFAOYSA-N 353770 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[3-(methoxymethyl)-3-methylazetidin-1-yl]ethanone::US9796708, Example 1002 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353770&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897403 386047503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697139 COCC1(F)CCN(C1)C(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353771 1-[3-fluoro-3-(methoxymethyl)pyrrolidin-1-yl]-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 1003 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353771&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897327 386047504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697140 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NC2CCC2)CC1 InChI=1S/C25H27FN4O2/c1-32-23-6-5-17(26)13-20(23)19-7-10-27-25-21(19)14-22(29-25)16-8-11-30(12-9-16)15-24(31)28-18-3-2-4-18/h5-8,10,13-14,18H,2-4,9,11-12,15H2,1H3,(H,27,29)(H,28,31) IPKMHFXPFSLIPC-UHFFFAOYSA-N 353772 N-cyclobutyl-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetamide::US9796708, Example 1004 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353772&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897334 386047505 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697141 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(F)C2)CC1 InChI=1S/C24H24F2N4O2/c1-32-22-3-2-16(25)10-19(22)18-4-7-27-24-20(18)11-21(28-24)15-5-8-29(9-6-15)14-23(31)30-12-17(26)13-30/h2-5,7,10-11,17H,6,8-9,12-14H2,1H3,(H,27,28) RTKNLWXYCIJLLR-UHFFFAOYSA-N 353773 1-(3-fluoroazetidin-1-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 1005 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353773&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897287 386047506 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697142 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NCCO)CC1 InChI=1S/C23H25FN4O3/c1-31-21-3-2-16(24)12-18(21)17-4-7-26-23-19(17)13-20(27-23)15-5-9-28(10-6-15)14-22(30)25-8-11-29/h2-5,7,12-13,29H,6,8-11,14H2,1H3,(H,25,30)(H,26,27) ORTBEUUIIPCKOJ-UHFFFAOYSA-N 353774 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1006 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 72.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353774&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208154 386047507 C04080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697143 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NC2CC(F)C2)CC1 InChI=1S/C25H26F2N4O2/c1-33-23-3-2-16(26)12-20(23)19-4-7-28-25-21(19)13-22(30-25)15-5-8-31(9-6-15)14-24(32)29-18-10-17(27)11-18/h2-5,7,12-13,17-18H,6,8-11,14H2,1H3,(H,28,30)(H,29,32) CUAUCNPSNDOQIK-UHFFFAOYSA-N 353775 N-(3-fluorocyclobutyl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetamide::US9796708, Example 1007 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353775&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897326 386047508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697144 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC(O)C2)CC1 353776 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-(3-hydroxypyrrolidin-1-yl)ethanone::US9796708, Example 1008 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353776&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420665 386047509 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697145 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1(C)C InChI=1S/C25H29FN4O2/c1-25(2)15-30(14-23(31)29(3)4)11-9-20(25)21-13-19-17(8-10-27-24(19)28-21)18-12-16(26)6-7-22(18)32-5/h6-10,12-13H,11,14-15H2,1-5H3,(H,27,28) IIJODWBAWGPKFL-UHFFFAOYSA-N 353777 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3-dimethyl-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 1009 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353777&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419526 386047510 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697146 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1(C)C 353778 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3-dimethyl-3,6-dihydropyridin-1(2H)-yl}propane-1,2-diol::US9796708, Example 1010 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353778&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419886 386047511 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697147 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2C(O)=O)CC1 InChI=1S/C26H29FN4O4/c1-35-23-5-4-17(27)13-19(23)18-6-9-28-25-20(18)14-21(29-25)16-7-11-30(12-8-16)15-24(32)31-10-2-3-22(31)26(33)34/h4-6,9,13-14,16,22H,2-3,7-8,10-12,15H2,1H3,(H,28,29)(H,33,34)/t22-/m0/s1 WUHVWXWLXLIPPN-QFIPXVFZSA-N 353779 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetyl)-L-proline::US9796708, Example 1011 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 98.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353779&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420686 386047512 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697148 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2C(O)=O)CC1 InChI=1S/C26H27FN4O4/c1-35-23-5-4-17(27)13-19(23)18-6-9-28-25-20(18)14-21(29-25)16-7-11-30(12-8-16)15-24(32)31-10-2-3-22(31)26(33)34/h4-7,9,13-14,22H,2-3,8,10-12,15H2,1H3,(H,28,29)(H,33,34)/t22-/m0/s1 OOJDWZCGWHODGV-QFIPXVFZSA-N 353780 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetyl)-L-proline::US9796708, Example 1012 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353780&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420347 386047513 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697149 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)NS(C)(=O)=O)CC1 InChI=1S/C22H25FN4O4S/c1-31-20-4-3-15(23)11-17(20)16-5-8-24-22-18(16)12-19(25-22)14-6-9-27(10-7-14)13-21(28)26-32(2,29)30/h3-5,8,11-12,14H,6-7,9-10,13H2,1-2H3,(H,24,25)(H,26,28) IJPYCMPCJZNRGK-UHFFFAOYSA-N 353781 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-(methylsulfonyl)acetamide::US9796708, Example 1013 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353781&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420772 386047514 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697150 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2C[C@H](O)[C@@H](O)C2)CC1 InChI=1S/C25H29FN4O4/c1-34-23-3-2-16(26)10-18(23)17-4-7-27-25-19(17)11-20(28-25)15-5-8-29(9-6-15)14-24(33)30-12-21(31)22(32)13-30/h2-4,7,10-11,15,21-22,31-32H,5-6,8-9,12-14H2,1H3,(H,27,28)/t21-,22-/m0/s1 SEAFLVCMIFOEQZ-VXKWHMMOSA-N 353782 1-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 1014 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353782&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897261 386047515 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697151 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2C[C@H](O)[C@@H](O)C2)CC1 InChI=1S/C25H27FN4O4/c1-34-23-3-2-16(26)10-18(23)17-4-7-27-25-19(17)11-20(28-25)15-5-8-29(9-6-15)14-24(33)30-12-21(31)22(32)13-30/h2-5,7,10-11,21-22,31-32H,6,8-9,12-14H2,1H3,(H,27,28)/t21-,22-/m0/s1 MZWHUOUPXXIHRZ-VXKWHMMOSA-N 353783 1-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethanone::US9796708, Example 1015 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353783&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897478 386047516 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696304 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(Cc2ccncc2)C1 InChI=1S/C23H21FN4O/c1-29-22-3-2-17(24)10-19(22)18-6-9-26-23-20(18)11-21(27-23)16-13-28(14-16)12-15-4-7-25-8-5-15/h2-11,16H,12-14H2,1H3,(H,26,27) BEKDHNCHSVXTLU-UHFFFAOYSA-N 167680 US9073922, 167::US9796708, Example 167 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167680&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412871 312321525 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696305 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(C1)C(C)=O InChI=1S/C19H18FN3O2/c1-11(24)23-9-12(10-23)17-8-16-14(5-6-21-19(16)22-17)15-7-13(20)3-4-18(15)25-2/h3-8,12H,9-10H2,1-2H3,(H,21,22) GEQKQFOGSYEMND-UHFFFAOYSA-N 167681 US9073922, 168::US9796708, Example 168 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167681&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412094 312321526 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696306 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(CCN)C1 InChI=1S/C19H21FN4O/c1-25-18-3-2-13(20)8-15(18)14-4-6-22-19-16(14)9-17(23-19)12-10-24(11-12)7-5-21/h2-4,6,8-9,12H,5,7,10-11,21H2,1H3,(H,22,23) MPHAJIGAVWYFEU-UHFFFAOYSA-N 167682 US9073922, 169::US9796708, Example 169 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167682&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412302 312321527 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696307 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(CC2CCOCC2)C1 InChI=1S/C23H26FN3O2/c1-28-22-3-2-17(24)10-19(22)18-4-7-25-23-20(18)11-21(26-23)16-13-27(14-16)12-15-5-8-29-9-6-15/h2-4,7,10-11,15-16H,5-6,8-9,12-14H2,1H3,(H,25,26) BGBLAXBERYFBCR-UHFFFAOYSA-N 167683 US9073922, 170::US9796708, Example 170 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 290 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167683&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413916 312321528 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696308 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(CCN2CCOCC2)C1 InChI=1S/C23H27FN4O2/c1-29-22-3-2-17(24)12-19(22)18-4-5-25-23-20(18)13-21(26-23)16-14-28(15-16)7-6-27-8-10-30-11-9-27/h2-5,12-13,16H,6-11,14-15H2,1H3,(H,25,26) WMXZVSWVLWFDPS-UHFFFAOYSA-N 167684 US9073922, 171::US9796708, Example 171 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167684&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412646 312321529 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696309 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(CCO)C1 InChI=1S/C19H20FN3O2/c1-25-18-3-2-13(20)8-15(18)14-4-5-21-19-16(14)9-17(22-19)12-10-23(11-12)6-7-24/h2-5,8-9,12,24H,6-7,10-11H2,1H3,(H,21,22) RKAOLBJIYCDEQZ-UHFFFAOYSA-N 167685 US9073922, 172::US9796708, Example 172 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167685&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412731 312321530 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696310 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCN(C2)C(=O)OC(C)(C)C)ccc1Cl 167686 US9073922, 173::US9796708, Example 173 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167686&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412827 312321531 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696311 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCS(=O)(=O)CC2)ccc1Cl InChI=1S/C24H30ClN5O2S/c1-30-10-5-17(6-11-30)21-14-19-18(4-9-26-24(19)28-21)23-20(25)2-3-22(29-23)27-15-16-7-12-33(31,32)13-8-16/h2-4,9,14,16-17H,5-8,10-13,15H2,1H3,(H,26,28)(H,27,29) WMEPQUCCPPCRTP-UHFFFAOYSA-N 167687 US9073922, 174::US9796708, Example 174 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167687&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412550 312321532 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696312 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2cccc(OCC(O)=O)c2)ccc1Cl InChI=1S/C27H28ClN5O3/c1-33-11-8-18(9-12-33)23-14-21-20(7-10-29-27(21)31-23)26-22(28)5-6-24(32-26)30-15-17-3-2-4-19(13-17)36-16-25(34)35/h2-7,10,13-14,18H,8-9,11-12,15-16H2,1H3,(H,29,31)(H,30,32)(H,34,35) RDRPFFCVZPBWTJ-UHFFFAOYSA-N 167688 US9073922, 175::US9796708, Example 175 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167688&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413881 312321533 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696313 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2ccc(OCC(O)=O)cc2)ccc1Cl InChI=1S/C27H28ClN5O3/c1-33-12-9-18(10-13-33)23-14-21-20(8-11-29-27(21)31-23)26-22(28)6-7-24(32-26)30-15-17-2-4-19(5-3-17)36-16-25(34)35/h2-8,11,14,18H,9-10,12-13,15-16H2,1H3,(H,29,31)(H,30,32)(H,34,35) RSHDKPJMNNMKBZ-UHFFFAOYSA-N 167689 US9073922, 176::US9796708, Example 176 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167689&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411868 312321534 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696314 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCN(CC2)C(C)=O)ccc1Cl InChI=1S/C26H33ClN6O/c1-17(34)33-13-6-18(7-14-33)16-29-24-4-3-22(27)25(31-24)20-5-10-28-26-21(20)15-23(30-26)19-8-11-32(2)12-9-19/h3-5,10,15,18-19H,6-9,11-14,16H2,1-2H3,(H,28,30)(H,29,31) OVQMFQSWSVOSFZ-UHFFFAOYSA-N 167690 US9073922, 177::US9796708, Example 177 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167690&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412173 312321535 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696315 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2nnc[nH]2)ccc1Cl InChI=1S/C21H23ClN8/c1-30-8-5-13(6-9-30)17-10-15-14(4-7-23-21(15)27-17)20-16(22)2-3-18(28-20)24-11-19-25-12-26-29-19/h2-4,7,10,12-13H,5-6,8-9,11H2,1H3,(H,23,27)(H,24,28)(H,25,26,29) AVDFGQCHSCXTLI-UHFFFAOYSA-N 167691 US9073922, 178::US9796708, Example 178 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167691&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412740 312321536 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696316 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCC2CCOCC2)ccc1F InChI=1S/C25H31FN4O/c1-30-10-5-18(6-11-30)24-15-22-20(4-9-27-25(22)29-24)21-14-19(2-3-23(21)26)28-16-17-7-12-31-13-8-17/h2-4,9,14-15,17-18,28H,5-8,10-13,16H2,1H3,(H,27,29) NTXRYOUSFHRQKM-UHFFFAOYSA-N 167692 US9073922, 179::US9796708, Example 179 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167692&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411757 312321537 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696317 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CN1CCCCC1 InChI=1S/C26H31FN4O2/c1-33-24-6-5-19(27)15-21(24)20-7-10-28-26-22(20)16-23(29-26)18-8-13-31(14-9-18)25(32)17-30-11-3-2-4-12-30/h5-7,10,15-16,18H,2-4,8-9,11-14,17H2,1H3,(H,28,29) NFYAKBSXKZSNFL-UHFFFAOYSA-N 167693 US9073922, 180::US9796708, Example 180 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167693&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412308 312321538 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696318 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CN1CCOCC1 InChI=1S/C25H29FN4O3/c1-32-23-3-2-18(26)14-20(23)19-4-7-27-25-21(19)15-22(28-25)17-5-8-30(9-6-17)24(31)16-29-10-12-33-13-11-29/h2-4,7,14-15,17H,5-6,8-13,16H2,1H3,(H,27,28) CKXGDSJCBQWPFS-UHFFFAOYSA-N 167694 US9073922, 181::US9796708, Example 181 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167694&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413239 312321539 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696319 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CNC1CCC(O)CC1 InChI=1S/C27H33FN4O3/c1-35-25-7-2-18(28)14-22(25)21-8-11-29-27-23(21)15-24(31-27)17-9-12-32(13-10-17)26(34)16-30-19-3-5-20(33)6-4-19/h2,7-8,11,14-15,17,19-20,30,33H,3-6,9-10,12-13,16H2,1H3,(H,29,31) MFMGZBUGOSVXOS-UHFFFAOYSA-N 167695 US9073922, 182::US9796708, Example 182 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167695&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412542 312321540 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696320 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CNCCO InChI=1S/C23H27FN4O3/c1-31-21-3-2-16(24)12-18(21)17-4-7-26-23-19(17)13-20(27-23)15-5-9-28(10-6-15)22(30)14-25-8-11-29/h2-4,7,12-13,15,25,29H,5-6,8-11,14H2,1H3,(H,26,27) QTROMHAUINAJRE-UHFFFAOYSA-N 167696 US9073922, 183::US9796708, Example 183 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167696&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412643 312321541 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696321 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(C)C1 InChI=1S/C18H18FN3O/c1-22-9-11(10-22)16-8-15-13(5-6-20-18(15)21-16)14-7-12(19)3-4-17(14)23-2/h3-8,11H,9-10H2,1-2H3,(H,20,21) FOASHGSNZZBDDP-UHFFFAOYSA-N 167697 US9073922, 184::US9796708, Example 184 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167697&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412769 312321542 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696322 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CN(C1)S(C)(=O)=O InChI=1S/C18H18FN3O3S/c1-25-17-4-3-12(19)7-14(17)13-5-6-20-18-15(13)8-16(21-18)11-9-22(10-11)26(2,23)24/h3-8,11H,9-10H2,1-2H3,(H,20,21) JRULDPYFBARTPK-UHFFFAOYSA-N 167698 US9073922, 185::US9796708, Example 185 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167698&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412584 312321543 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696323 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 167699 US9073922, 186::US9796708, Example 186 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167699&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414175 312321544 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696324 Nc1ccc(F)c(c1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C18H19FN4/c19-16-2-1-12(20)9-14(16)13-5-8-22-18-15(13)10-17(23-18)11-3-6-21-7-4-11/h1-2,5,8-11,21H,3-4,6-7,20H2,(H,22,23) RHHQNSIWSWQQJF-UHFFFAOYSA-N 167700 US9073922, 187::US9796708, Example 187 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167700&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412227 312321545 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696325 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2cccc(c2)S(C)(=O)=O)ccc1Cl InChI=1S/C26H28ClN5O2S/c1-32-12-9-18(10-13-32)23-15-21-20(8-11-28-26(21)30-23)25-22(27)6-7-24(31-25)29-16-17-4-3-5-19(14-17)35(2,33)34/h3-8,11,14-15,18H,9-10,12-13,16H2,1-2H3,(H,28,30)(H,29,31) KJLPGYJXHUHGNJ-UHFFFAOYSA-N 167701 US9073922, 188::US9796708, Example 188 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167701&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411641 312321546 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696326 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccncc2)ccc1F InChI=1S/C25H26FN5/c1-31-12-7-18(8-13-31)24-15-22-20(6-11-28-25(22)30-24)21-14-19(2-3-23(21)26)29-16-17-4-9-27-10-5-17/h2-6,9-11,14-15,18,29H,7-8,12-13,16H2,1H3,(H,28,30) JZTUSDTUSMMHGC-UHFFFAOYSA-N 167702 US9073922, 189::US9796708, Example 189 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167702&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412903 312321547 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696327 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)S(C)(=O)=O)ccc1F InChI=1S/C27H29FN4O2S/c1-32-13-10-19(11-14-32)26-16-24-22(9-12-29-27(24)31-26)23-15-20(5-8-25(23)28)30-17-18-3-6-21(7-4-18)35(2,33)34/h3-9,12,15-16,19,30H,10-11,13-14,17H2,1-2H3,(H,29,31) PDCHCLPILDWNBF-UHFFFAOYSA-N 167703 US9073922, 190::US9796708, Example 190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167703&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411911 312321548 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696328 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)C(N)=O)ccc1F InChI=1S/C27H28FN5O/c1-33-12-9-18(10-13-33)25-15-23-21(8-11-30-27(23)32-25)22-14-20(6-7-24(22)28)31-16-17-2-4-19(5-3-17)26(29)34/h2-8,11,14-15,18,31H,9-10,12-13,16H2,1H3,(H2,29,34)(H,30,32) FRTXIRRMROGTAJ-UHFFFAOYSA-N 167704 US9073922, 191::US9796708, Example 191 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167704&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413310 312321549 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696329 O[C@@H]1CN[C@@H](CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)C1 InChI=1S/C22H27ClN6O/c23-18-1-2-20(27-11-14-9-15(30)12-26-14)29-21(18)16-5-8-25-22-17(16)10-19(28-22)13-3-6-24-7-4-13/h1-2,5,8,10,13-15,24,26,30H,3-4,6-7,9,11-12H2,(H,25,28)(H,27,29)/t14-,15+/m1/s1 JRLVVHBERLJGMR-CABCVRRESA-N 167705 US9073922, 192::US9796708, Example 192 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 810 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167705&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413437 312321550 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696330 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCCNC1 167706 US9073922, 193::US9796708, Example 193 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167706&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413024 312321551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696331 Fc1ccc(NCc2ccccc2)cc1-c1c(Cl)cnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H24ClFN4/c26-21-15-30-25-20(13-23(31-25)17-8-10-28-11-9-17)24(21)19-12-18(6-7-22(19)27)29-14-16-4-2-1-3-5-16/h1-7,12-13,15,17,28-29H,8-11,14H2,(H,30,31) BWZCJUTXKGJQBP-UHFFFAOYSA-N 167708 US9073922, 195::US9796708, Example 195 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167708&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414008 312321552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696332 F[C@@H]1CN[C@H](CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)C1 InChI=1S/C22H26ClFN6/c23-18-1-2-20(28-12-15-9-14(24)11-27-15)30-21(18)16-5-8-26-22-17(16)10-19(29-22)13-3-6-25-7-4-13/h1-2,5,8,10,13-15,25,27H,3-4,6-7,9,11-12H2,(H,26,29)(H,28,30)/t14-,15-/m0/s1 MQANNSLVFICJTQ-GJZGRUSLSA-N 167709 US9073922, 196::US9796708, Example 196 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 910 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167709&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412605 312321553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696333 Clc1cnc(NCC2(CCOCC2)C#N)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H27ClN6O/c25-20-13-29-22(30-15-24(14-26)4-9-32-10-5-24)12-18(20)17-3-8-28-23-19(17)11-21(31-23)16-1-6-27-7-2-16/h3,8,11-13,16,27H,1-2,4-7,9-10,15H2,(H,28,31)(H,29,30) LZMWPSWEYIOCAB-UHFFFAOYSA-N 167710 US9073922, 197::US9796708, Example 197 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 730 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167710&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412221 312321554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696334 FC1(F)CN[C@H](CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCNCC2)C1 InChI=1S/C22H25ClF2N6/c23-17-1-2-19(28-11-14-10-22(24,25)12-29-14)31-20(17)15-5-8-27-21-16(15)9-18(30-21)13-3-6-26-7-4-13/h1-2,5,8-9,13-14,26,29H,3-4,6-7,10-12H2,(H,27,30)(H,28,31)/t14-/m0/s1 HBEOMZCCUDXGFY-AWEZNQCLSA-N 167711 US9073922, 198::US9796708, Example 198 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167711&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412637 312321555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696335 Clc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167712 US9073922, 199::US9796708, Example 199 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167712&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413280 312321556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696336 CN(Cc1ccccc1)c1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCCNC1 167713 US9073922, 200::US9796708, Example 200 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167713&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412006 312321557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696337 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167714 US9073922, 201::US9796708, Example 201 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167714&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412296 312321558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696338 Fc1ccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCCNC2)cc1F 167715 US9073922, 202::US9796708, Example 202 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167715&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412841 312321559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696339 Fc1cccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCCNC2)c1 167716 US9073922, 203::US9796708, Example 203 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167716&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412010 312321560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696340 Fc1ccc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCCNC2)cc1 167717 US9073922, 204::US9796708, Example 204 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167717&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412742 312321561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696341 Clc1cnc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167718 US9073922, 205::US9796708, Example 205 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167718&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412676 312321562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696342 Fc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167719 US9073922, 206::US9796708, Example 206 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167719&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412445 312321563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696343 Fc1ccccc1CNc1ccc(Cl)c(n1)-c1ccnc2[nH]c(cc12)C1CCCNC1 167720 US9073922, 207::US9796708, Example 207 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167720&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412702 312321564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696344 Clc1ccc(NCc2cccnc2)nc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167721 US9073922, 208::US9796708, Example 208 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167721&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411118 312321565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696345 Clc1ccc(OCc2cccnc2)nc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167722 US9073922, 209::US9796708, Example 209 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167722&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411966 312321566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696346 Fc1cncc(CNc2ccc(Cl)c(n2)-c2ccnc3[nH]c(cc23)C2CCCNC2)c1 167723 US9073922, 210::US9796708, Example 210 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167723&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413826 312321567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696347 Fc1cnc(NCc2ccccc2)cc1-c1ccnc2[nH]c(cc12)C1CCCNC1 167724 US9073922, 211::US9796708, Example 211 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167724&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411750 312321568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696348 Fc1cc(NCc2ccccc2)nc(c1)-c1ccnc2[nH]c(cc12)C1CCCNC1 167725 US9073922, 212::US9796708, Example 212 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167725&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413763 312321569 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696349 Clc1cnc2[nH]c(cc2c1-c1ccnc(NCc2ccccc2)c1)C1CCCNC1 167726 US9073922, 213::US9796708, Example 213 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167726&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411717 312321570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696350 Fc1cccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCCNC2)c1 167727 US9073922, 214::US9796708, Example 214 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167727&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412381 312321571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696351 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H21FN4O2/c1-23-21(27)26-9-6-13(7-10-26)18-12-17-15(5-8-24-20(17)25-18)16-11-14(22)3-4-19(16)28-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,27)(H,24,25) ZPUBPIPZFAUDSS-UHFFFAOYSA-N 167728 US9073922, 215::US9796708, Example 215 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167728&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 81689869 312321572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696352 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(N)(=O)=O InChI=1S/C19H19FN4O3S/c1-27-18-3-2-13(20)10-15(18)14-4-7-22-19-16(14)11-17(23-19)12-5-8-24(9-6-12)28(21,25)26/h2-5,7,10-11H,6,8-9H2,1H3,(H,22,23)(H2,21,25,26) XFUXKSYIUVHEHS-UHFFFAOYSA-N 167729 US9073922, 216::US9796708, Example 216 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167729&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412711 312321573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696353 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccc(NC(C)=O)cc2)CC1 InChI=1S/C28H27FN4O2/c1-18(34)31-22-6-3-19(4-7-22)17-33-13-10-20(11-14-33)26-16-25-23(9-12-30-28(25)32-26)24-15-21(29)5-8-27(24)35-2/h3-10,12,15-16H,11,13-14,17H2,1-2H3,(H,30,32)(H,31,34) HIQLLZONXSJHKP-UHFFFAOYSA-N 167730 US9073922, 217::US9796708, Example 217 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167730&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412854 312321574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696354 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OC(C)(C)C InChI=1S/C24H27FN4O5S/c1-24(2,3)34-23(30)28-35(31,32)29-11-8-15(9-12-29)20-14-19-17(7-10-26-22(19)27-20)18-13-16(25)5-6-21(18)33-4/h5-8,10,13-14H,9,11-12H2,1-4H3,(H,26,27)(H,28,30) IFGGOHFFRBQPEK-UHFFFAOYSA-N 351926 US9796708, Example 218::tert-butyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208032 386046334 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696355 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 167732 US9073922, 219::US9796708, Example 219 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167732&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413704 312321576 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696356 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C19H17F2N3O2S/c1-27(25,26)24-9-6-12(7-10-24)17-11-15-13(5-8-22-19(15)23-17)14-3-2-4-16(20)18(14)21/h2-6,8,11H,7,9-10H2,1H3,(H,22,23) BISFFOQJTYBVMW-UHFFFAOYSA-N 167733 US9073922, 220::US9796708, Example 220 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167733&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412366 312321577 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697152 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](CO)C(O)=O InChI=1S/C23H24FN3O4/c1-31-21-7-4-14(24)10-17(21)16-8-9-25-22-18(16)11-19(27-22)13-2-5-15(6-3-13)26-20(12-28)23(29)30/h2,4,7-11,15,20,26,28H,3,5-6,12H2,1H3,(H,25,27)(H,29,30)/t15?,20-/m0/s1 YQCNIFTUQOYBTM-MBABXSBOSA-N 353784 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-serine::US9796708, Example 1016 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353784&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419920 386047517 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697153 CNC(=O)N1CC2CC(=CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353785 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9796708, Example 1017 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353785&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420130 386047518 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697154 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCNCC1 353786 4-(5-fluoro-2-methoxyphenyl)-2-[4-(piperazin-1-yl)cyclohex-1-en-1-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1018 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353786&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420643 386047519 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697155 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@H](C(C)C)C(=O)N(C)C InChI=1S/C27H33FN4O2/c1-16(2)25(27(33)32(3)4)30-19-9-6-17(7-10-19)23-15-22-20(12-13-29-26(22)31-23)21-14-18(28)8-11-24(21)34-5/h6,8,11-16,19,25,30H,7,9-10H2,1-5H3,(H,29,31)/t19?,25-/m1/s1 QFUHUMIJINMKCM-OPEAARRCSA-N 353787 N2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-N,N-dimethyl-D-valinamide::US9796708, Example 1019 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353787&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419927 386047520 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697156 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1C[C@H](O)C[C@H]1C(O)=O InChI=1S/C25H26FN3O4/c1-33-23-7-4-15(26)10-19(23)18-8-9-27-24-20(18)12-21(28-24)14-2-5-16(6-3-14)29-13-17(30)11-22(29)25(31)32/h2,4,7-10,12,16-17,22,30H,3,5-6,11,13H2,1H3,(H,27,28)(H,31,32)/t16?,17-,22+/m1/s1 QAFDHGUPVMOVIS-FNQQBUSASA-N 353788 (4R)-1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-4-hydroxy-L-proline::US9796708, Example 1020 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353788&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897460 386047521 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697157 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](C(C)C)C(O)=O InChI=1S/C25H28FN3O3/c1-14(2)23(25(30)31)28-17-7-4-15(5-8-17)21-13-20-18(10-11-27-24(20)29-21)19-12-16(26)6-9-22(19)32-3/h4,6,9-14,17,23,28H,5,7-8H2,1-3H3,(H,27,29)(H,30,31)/t17?,23-/m0/s1 VKEWATIKYFEHIF-VXLWULRPSA-N 353789 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-valine::US9796708, Example 1021 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353789&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421651 386047522 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697158 CNC(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1OC InChI=1S/C22H26N4O2/c1-23-21(27)14-26-11-8-15(9-12-26)19-13-18-16(7-10-24-22(18)25-19)17-5-3-4-6-20(17)28-2/h3-7,10,13,15H,8-9,11-12,14H2,1-2H3,(H,23,27)(H,24,25) FAFLKBFUYXLILQ-UHFFFAOYSA-N 353790 2-{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methylacetamide::US9796708, Example 1022 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353790&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420469 386047523 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697159 COc1ccccc1-c1ccnc2[nH]c(cc12)C1CCN(CC(O)=O)CC1 InChI=1S/C21H23N3O3/c1-27-19-5-3-2-4-16(19)15-6-9-22-21-17(15)12-18(23-21)14-7-10-24(11-8-14)13-20(25)26/h2-6,9,12,14H,7-8,10-11,13H2,1H3,(H,22,23)(H,25,26) DZVAUAMJBWNKHH-UHFFFAOYSA-N 353791 US9796708, Example 1023::{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353791&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897255 386047524 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697160 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](C)N(CC(=O)N(C)C)CC1 InChI=1S/C24H27FN4O2/c1-15-11-16(8-10-29(15)14-23(30)28(2)3)21-13-20-18(7-9-26-24(20)27-21)19-12-17(25)5-6-22(19)31-4/h5-7,9,11-13,15H,8,10,14H2,1-4H3,(H,26,27)/t15-/m0/s1 QKRBYSFEJAYDEK-HNNXBMFYSA-N 353792 2-[(6S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide::US9796708, Example 1024 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353792&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419707 386047525 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697161 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](C)NCC1 InChI=1S/C20H20FN3O/c1-12-9-13(5-7-22-12)18-11-17-15(6-8-23-20(17)24-18)16-10-14(21)3-4-19(16)25-2/h3-4,6,8-12,22H,5,7H2,1-2H3,(H,23,24)/t12-/m1/s1 WSCONERQESPBQY-GFCCVEGCSA-N 353793 4-(5-fluoro-2-methoxyphenyl)-2-[(6R)-6-methyl-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1025::US9796708, Example 1144 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353793&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420421 386047526 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697162 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN([C@@H](C)C1)S(C)(=O)=O InChI=1S/C21H24FN3O3S/c1-13-10-14(7-9-25(13)29(3,26)27)19-12-18-16(6-8-23-21(18)24-19)17-11-15(22)4-5-20(17)28-2/h4-6,8,11-14H,7,9-10H2,1-3H3,(H,23,24)/t13-,14?/m0/s1 TUYAIQQAZOKIQY-LSLKUGRBSA-N 353794 4-(5-fluoro-2-methoxyphenyl)-2-[(2S)-2-methyl-1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1026 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353794&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421206 386047527 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697163 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)OCC(O)=O 353795 ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}oxy)acetic acid::US9796708, Example 1027 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353795&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420459 386047528 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697164 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H]([C@@H](C)O)C(O)=O InChI=1S/C24H26FN3O4/c1-13(29)22(24(30)31)27-16-6-3-14(4-7-16)20-12-19-17(9-10-26-23(19)28-20)18-11-15(25)5-8-21(18)32-2/h3,5,8-13,16,22,27,29H,4,6-7H2,1-2H3,(H,26,28)(H,30,31)/t13-,16?,22+/m1/s1 NGZRNKMVKHTZBU-MPTZHHAHSA-N 353796 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-threonine::US9796708, Example 1028 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353796&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421156 386047529 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697165 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N1CCS(=O)(=O)CC1 InChI=1S/C23H25FN4O5S2/c1-33-22-3-2-17(24)14-19(22)18-4-7-25-23-20(18)15-21(26-23)16-5-8-27(9-6-16)35(31,32)28-10-12-34(29,30)13-11-28/h2-5,7,14-15H,6,8-13H2,1H3,(H,25,26) HSOGHAYVSZVORN-UHFFFAOYSA-N 353797 2-{1-[(1,1-dioxidothiomorpholin-4-yl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1029 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353797&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897461 386047530 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697166 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C24H28FN5O3S/c1-28-11-13-30(14-12-28)34(31,32)29-9-6-17(7-10-29)22-16-21-19(5-8-26-24(21)27-22)20-15-18(25)3-4-23(20)33-2/h3-6,8,15-16H,7,9-14H2,1-2H3,(H,26,27) MCFNPOIXKOKJDB-UHFFFAOYSA-N 353798 4-(5-fluoro-2-methoxyphenyl)-2-{1-[(4-methylpiperazin-1-yl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1030 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353798&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897293 386047531 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697167 CCOC(=O)C1CCN(CC1)S(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H31FN4O5S/c1-3-37-27(33)19-9-14-32(15-10-19)38(34,35)31-12-7-18(8-13-31)24-17-23-21(6-11-29-26(23)30-24)22-16-20(28)4-5-25(22)36-2/h4-7,11,16-17,19H,3,8-10,12-15H2,1-2H3,(H,29,30) WDNWWOWCIQQXFT-UHFFFAOYSA-N 353799 US9796708, Example 1031::ethyl 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)piperidine-4-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 850 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353799&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897430 386047532 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697168 CCOC(=O)[C@@H]1CCCN1S(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C26H29FN4O5S/c1-3-36-26(32)23-5-4-12-31(23)37(33,34)30-13-9-17(10-14-30)22-16-21-19(8-11-28-25(21)29-22)20-15-18(27)6-7-24(20)35-2/h6-9,11,15-16,23H,3-5,10,12-14H2,1-2H3,(H,28,29)/t23-/m0/s1 CIYUYCXSUUWJIS-QHCPKHFHSA-N 353800 US9796708, Example 1032::ethyl 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)prolinate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 440 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353800&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897374 386047533 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697169 CCOC(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H24FN3O3/c1-3-30-22(28)14-27-10-7-15(8-11-27)20-13-19-17(6-9-25-23(19)26-20)18-12-16(24)4-5-21(18)29-2/h4-7,9,12-13H,3,8,10-11,14H2,1-2H3,(H,25,26) TXJQQSQBJBZBNT-UHFFFAOYSA-N 353801 US9796708, Example 1033::ethyl {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353801&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208155 386047534 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697170 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)OC(C)C)CC1 InChI=1S/C24H26FN3O3/c1-15(2)31-23(29)14-28-10-7-16(8-11-28)21-13-20-18(6-9-26-24(20)27-21)19-12-17(25)4-5-22(19)30-3/h4-7,9,12-13,15H,8,10-11,14H2,1-3H3,(H,26,27) SWMXRMFVJWDGJP-UHFFFAOYSA-N 353802 US9796708, Example 1034::propan-2-yl {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353802&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208156 386047535 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697171 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H19FN4O3/c1-30-18-3-2-14(23)10-16(18)15-4-7-25-22-20(15)17(11-24)21(26-22)13-5-8-27(9-6-13)12-19(28)29/h2-5,7,10H,6,8-9,12H2,1H3,(H,25,26)(H,28,29) PHFXFDXBJSMFCO-UHFFFAOYSA-N 353803 US9796708, Example 1035::{4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353803&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897303 386047536 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697172 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H28FN5O3/c1-36-23-5-4-18(28)13-21(23)20-6-9-30-27-25(20)22(14-29)26(31-27)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-7,9,13,19,34H,2-3,8,10-12,15-16H2,1H3,(H,30,31)/t19-/m0/s1 QBQYJKOLUACTDE-IBGZPJMESA-N 353804 4-(5-fluoro-2-methoxyphenyl)-2-(1-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1036 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353804&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419951 386047537 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697173 CCOc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C20H19F2N3O/c1-2-26-19-11-17(22)16(21)9-14(19)13-5-8-24-20-15(13)10-18(25-20)12-3-6-23-7-4-12/h3,5,8-11,23H,2,4,6-7H2,1H3,(H,24,25) XDNKQEVZHYPHGZ-UHFFFAOYSA-N 353805 4-(2-ethoxy-4,5-difluorophenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1037 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353805&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420356 386047538 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697174 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC(C)(C)O InChI=1S/C24H27FN4O6S/c1-24(2,31)14-35-23(30)28-36(32,33)29-10-7-15(8-11-29)20-13-19-17(6-9-26-22(19)27-20)18-12-16(25)4-5-21(18)34-3/h4-7,9,12-13,31H,8,10-11,14H2,1-3H3,(H,26,27)(H,28,30) ZRWSGQYFMCIXRJ-UHFFFAOYSA-N 353806 2-hydroxy-2-methylpropyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 1038 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353806&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419858 386047539 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697175 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC1COC(C)(C)O1 353807 (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 1039 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353807&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419678 386047540 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697176 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC1CCOCC1 InChI=1S/C26H29FN4O6S/c1-35-24-3-2-19(27)14-21(24)20-4-9-28-25-22(20)15-23(29-25)18-5-10-31(11-6-18)38(33,34)30-26(32)37-16-17-7-12-36-13-8-17/h2-5,9,14-15,17H,6-8,10-13,16H2,1H3,(H,28,29)(H,30,32) ZJLSPUTVFCTSTL-UHFFFAOYSA-N 353808 US9796708, Example 1040::tetrahydro-2H-pyran-4-ylmethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353808&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420820 386047541 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697177 CCOc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H21F2N3O3S/c1-3-29-20-12-18(23)17(22)10-15(20)14-4-7-24-21-16(14)11-19(25-21)13-5-8-26(9-6-13)30(2,27)28/h4-5,7,10-12H,3,6,8-9H2,1-2H3,(H,24,25) HACVOMYVBQRXQF-UHFFFAOYSA-N 353809 4-(2-ethoxy-4,5-difluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1041 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353809&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421414 386047542 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697178 CCOc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NC InChI=1S/C22H22F2N4O2/c1-3-30-20-12-18(24)17(23)10-15(20)14-4-7-26-21-16(14)11-19(27-21)13-5-8-28(9-6-13)22(29)25-2/h4-5,7,10-12H,3,6,8-9H2,1-2H3,(H,25,29)(H,26,27) XUISQEMTZQAJSB-UHFFFAOYSA-N 353810 4-[4-(2-ethoxy-4,5-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 1042 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353810&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421276 386047543 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697179 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C26H30F2N4O3/c1-35-23-5-4-17(27)11-19(23)25-20-12-22(30-26(20)29-13-21(25)28)16-6-9-31(10-7-16)14-24(34)32-8-2-3-18(32)15-33/h4-5,11-13,16,18,33H,2-3,6-10,14-15H2,1H3,(H,29,30)/t18-/m0/s1 QUDGURAXXUXRNL-SFHVURJKSA-N 353811 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1043 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353811&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421849 386047544 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697180 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN[C@H](CO)C1 InChI=1S/C20H20FN3O2/c1-26-19-3-2-13(21)9-16(19)15-5-7-23-20-17(15)10-18(24-20)12-4-6-22-14(8-12)11-25/h2-5,7,9-10,14,22,25H,6,8,11H2,1H3,(H,23,24)/t14-/m0/s1 WTCATEFCXLZNCB-AWEZNQCLSA-N 353812 US9796708, Example 1044::{(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,6-tetrahydropyridin-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353812&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412072 386047545 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697181 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](CO)NCC1 InChI=1S/C20H20FN3O2/c1-26-19-3-2-13(21)9-16(19)15-5-7-23-20-17(15)10-18(24-20)12-4-6-22-14(8-12)11-25/h2-3,5,7-10,14,22,25H,4,6,11H2,1H3,(H,23,24)/t14-/m0/s1 AOXMZOYTPIOGHV-AWEZNQCLSA-N 353813 US9796708, Example 1045::{(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,5,6-tetrahydropyridin-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353813&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420139 386047546 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697182 CNC(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)c(F)cc1OC InChI=1S/C22H24F2N4O2/c1-25-21(29)12-28-7-4-13(5-8-28)19-10-16-14(3-6-26-22(16)27-19)15-9-17(23)18(24)11-20(15)30-2/h3,6,9-11,13H,4-5,7-8,12H2,1-2H3,(H,25,29)(H,26,27) PKIYKJKTKZOFMV-UHFFFAOYSA-N 353814 2-{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methylacetamide::US9796708, Example 1046 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353814&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420111 386047547 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697183 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H26F2N4O2/c1-28(2)22(30)13-29-8-5-14(6-9-29)20-11-17-15(4-7-26-23(17)27-20)16-10-18(24)19(25)12-21(16)31-3/h4,7,10-12,14H,5-6,8-9,13H2,1-3H3,(H,26,27) INOYMVUZYSRJIE-UHFFFAOYSA-N 353815 2-{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N,N-dimethylacetamide::US9796708, Example 1047 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353815&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420596 386047548 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697184 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(N)=O)CCC1 InChI=1S/C22H23FN4O2/c1-29-20-5-4-15(23)11-17(20)16-6-8-25-22-18(16)12-19(26-22)14-3-2-9-27(10-7-14)13-21(24)28/h4-8,11-12H,2-3,9-10,13H2,1H3,(H2,24,28)(H,25,26) LGHXAHICBOBHIZ-UHFFFAOYSA-N 353816 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,4,7-tetrahydro-1H-azepin-1-yl}acetamide::US9796708, Example 1048 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353816&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897262 386047549 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697185 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CCC1 InChI=1S/C24H27FN4O2/c1-28(2)23(30)15-29-11-4-5-16(9-12-29)21-14-20-18(8-10-26-24(20)27-21)19-13-17(25)6-7-22(19)31-3/h6-10,13-14H,4-5,11-12,15H2,1-3H3,(H,26,27) RVLKXMXSSGTNED-UHFFFAOYSA-N 353817 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,4,7-tetrahydro-1H-azepin-1-yl})-N,N-dimethylacetamide::US9796708, Example 1049 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420768 386047550 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697186 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N[C@@H]2[C@@H]3C[C@@H](C=C3)[C@@H]2C(N)=O)CC1 InChI=1S/C29H29F2N5O3/c1-39-24-13-22(31)21(30)11-19(24)18-4-7-33-29-20(18)12-23(34-29)15-5-8-36(9-6-15)14-25(37)35-27-17-3-2-16(10-17)26(27)28(32)38/h2-5,7,11-13,16-17,26-27H,6,8-10,14H2,1H3,(H2,32,38)(H,33,34)(H,35,37)/t16-,17+,26+,27-/m1/s1 LIJYXQIVUKWZFJ-QJYJSFKDSA-N 353818 (1 S,2S,3R,4R)-3-[({4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetyl)amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide::US9796708, Example 1050 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420020 386047551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697187 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)N1CCC[C@H]1CO InChI=1S/C26H28FN3O3/c1-33-24-9-8-18(27)13-21(24)20-10-11-28-25-22(20)14-23(29-25)16-4-6-17(7-5-16)26(32)30-12-2-3-19(30)15-31/h4,8-11,13-14,17,19,31H,2-3,5-7,12,15H2,1H3,(H,28,29)/t17?,19-/m0/s1 FGOCOWOAWMJWIB-NNBQYGFHSA-N 353819 US9796708, Example 1051::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353819&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897280 386047552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697188 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCN(CC(N)=O)CC1 InChI=1S/C21H23FN4O2/c1-28-19-10-14(22)2-3-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-26(9-6-13)12-20(23)27/h2-4,7,10-11,13H,5-6,8-9,12H2,1H3,(H2,23,27)(H,24,25) OPXBLMHUXUHKES-UHFFFAOYSA-N 353820 2-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetamide::US9796708, Example 1052 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353820&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897284 386047553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697189 CNC(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1ccc(F)cc1OC InChI=1S/C22H25FN4O2/c1-24-21(28)13-27-9-6-14(7-10-27)19-12-18-16(5-8-25-22(18)26-19)17-4-3-15(23)11-20(17)29-2/h3-5,8,11-12,14H,6-7,9-10,13H2,1-2H3,(H,24,28)(H,25,26) GTAXBMXLAQAOLV-UHFFFAOYSA-N 353821 2-{4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methylacetamide::US9796708, Example 1053 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353821&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419828 386047554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697190 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CNCC2C1 353822 4-(5-fluoro-2-methoxyphenyl)-2-(octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1054 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353822&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420910 386047555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697191 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)C(=O)CO InChI=1S/C21H21F2N3O3/c1-29-18-3-2-13(22)8-14(18)20-15-9-17(25-21(15)24-10-16(20)23)12-4-6-26(7-5-12)19(28)11-27/h2-3,8-10,12,27H,4-7,11H2,1H3,(H,24,25) AUJQZWCBPUQEHE-UHFFFAOYSA-N 353823 1-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-2-hydroxyethanone::US9796708, Example 1055 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353823&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420166 386047556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697192 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC1CCNC1 353824 US9796708, Example 1056::pyrrolidin-3-ylmethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353824&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419686 386047557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697193 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OC1CCNCC1 InChI=1S/C25H28FN5O5S/c1-35-23-3-2-17(26)14-20(23)19-6-11-28-24-21(19)15-22(29-24)16-7-12-31(13-8-16)37(33,34)30-25(32)36-18-4-9-27-10-5-18/h2-3,6-7,11,14-15,18,27H,4-5,8-10,12-13H2,1H3,(H,28,29)(H,30,32) PGUPCTFPBVZYBE-UHFFFAOYSA-N 353825 US9796708, Example 1057::piperidin-4-yl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353825&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420895 386047558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697194 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC1CCNCC1 InChI=1S/C26H30FN5O5S/c1-36-24-3-2-19(27)14-21(24)20-6-11-29-25-22(20)15-23(30-25)18-7-12-32(13-8-18)38(34,35)31-26(33)37-16-17-4-9-28-10-5-17/h2-3,6-7,11,14-15,17,28H,4-5,8-10,12-13,16H2,1H3,(H,29,30)(H,31,33) JFGQZFQSECIMIO-UHFFFAOYSA-N 353826 US9796708, Example 1058::piperidin-4-ylmethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353826&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420411 386047559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697195 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OC1CCNC1 353827 US9796708, Example 1059::pyrrolidin-3-yl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353827&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421005 386047560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697196 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC(O)CO 353828 2,3-dihydroxypropyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 1060 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353828&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420837 386047561 C01885 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697197 COC(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1OC InChI=1S/C22H25N3O3/c1-27-20-6-4-3-5-17(20)16-7-10-23-22-18(16)13-19(24-22)15-8-11-25(12-9-15)14-21(26)28-2/h3-7,10,13,15H,8-9,11-12,14H2,1-2H3,(H,23,24) QMWPLSYCMVAAIO-UHFFFAOYSA-N 353829 US9796708, Example 1061::methyl {4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353829&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208157 386047562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697198 COc1ccccc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C26H32N4O3/c1-33-24-7-3-2-6-21(24)20-8-11-27-26-22(20)15-23(28-26)18-9-13-29(14-10-18)16-25(32)30-12-4-5-19(30)17-31/h2-3,6-8,11,15,18-19,31H,4-5,9-10,12-14,16-17H2,1H3,(H,27,28)/t19-/m0/s1 PMDQHUKVXODMBQ-IBGZPJMESA-N 353830 1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-{4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 1062 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353830&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897267 386047563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697199 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@H](C(C)C)C(=O)N1CC(O)C1 InChI=1S/C28H33FN4O3/c1-16(2)26(28(35)33-14-20(34)15-33)31-19-7-4-17(5-8-19)24-13-23-21(10-11-30-27(23)32-24)22-12-18(29)6-9-25(22)36-3/h4,6,9-13,16,19-20,26,31,34H,5,7-8,14-15H2,1-3H3,(H,30,32)/t19?,26-/m1/s1 OFOGYQBBISRMGH-COTLDPOVSA-N 353831 (2R)-2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}amino)-1-(3-hydroxyazetidin-1-yl)-3-methylbutan-1-one::US9796708, Example 1063 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353831&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897332 386047564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697200 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCC[C@H]1C(=O)N(C)C InChI=1S/C27H31FN4O2/c1-31(2)27(33)24-5-4-14-32(24)19-9-6-17(7-10-19)23-16-22-20(12-13-29-26(22)30-23)21-15-18(28)8-11-25(21)34-3/h6,8,11-13,15-16,19,24H,4-5,7,9-10,14H2,1-3H3,(H,29,30)/t19?,24-/m0/s1 XWULJYIYLWLFBT-WIIYFNMSSA-N 353832 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-N,N-dimethyl-L-prolinamide::US9796708, Example 1064 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353832&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420921 386047565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697201 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](C(O)=O)c1ccccc1 InChI=1S/C28H26FN3O3/c1-35-25-12-9-19(29)15-22(25)21-13-14-30-27-23(21)16-24(32-27)17-7-10-20(11-8-17)31-26(28(33)34)18-5-3-2-4-6-18/h2-7,9,12-16,20,26,31H,8,10-11H2,1H3,(H,30,32)(H,33,34)/t20?,26-/m1/s1 XRBMYCWQPVWCER-NBXNUCLWSA-N 353833 (2R)-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}amino)(phenyl)acetic acid::US9796708, Example 1065 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353833&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420897 386047566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697202 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C12CC1CN(CC2)S(C)(=O)=O 353834 4-(5-fluoro-2-methoxyphenyl)-2-[3-(methylsulfonyl)-3-azabicyclo[4.1.0]hept-6-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1066 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353834&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419776 386047567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697203 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)c1nnn[nH]1 353835 4-(5-fluoro-2-methoxyphenyl)-2-[4-(1H-tetrazol-5-yl)cyclohex-1-en-1-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1067 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353835&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420322 386047568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696357 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC#N InChI=1S/C22H19FN4O2/c1-29-20-3-2-15(23)12-17(20)16-5-9-25-22-18(16)13-19(26-22)14-6-10-27(11-7-14)21(28)4-8-24/h2-3,5-6,9,12-13H,4,7,10-11H2,1H3,(H,25,26) RIUQJGVJWYACAJ-UHFFFAOYSA-N 167734 US9073922, 221::US9796708, Example 221 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167734&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412036 312321578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696358 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C20H18F2N4O/c1-23-20(27)26-9-6-12(7-10-26)17-11-15-13(5-8-24-19(15)25-17)14-3-2-4-16(21)18(14)22/h2-6,8,11H,7,9-10H2,1H3,(H,23,27)(H,24,25) XGVPHUYYONBSBD-UHFFFAOYSA-N 167735 US9073922, 222::US9796708, Example 222 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167735&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413195 312321579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696359 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2S(C)(=O)=O 60456 US9073922, 223::US9796708, Example 223 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412762 313362588 ZINC17440346 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696360 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H25FN4O2/c1-27(2)22(29)14-28-10-7-15(8-11-28)20-13-19-17(6-9-25-23(19)26-20)18-12-16(24)4-5-21(18)30-3/h4-7,9,12-13H,8,10-11,14H2,1-3H3,(H,25,26) FWXIKQBBCWJCQD-UHFFFAOYSA-N 167736 US9073922, 224::US9796708, Example 224 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167736&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413261 312321580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696361 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)Nc1cnn(C)c1 InChI=1S/C24H23FN6O2/c1-30-14-17(13-27-30)28-24(32)31-9-6-15(7-10-31)21-12-20-18(5-8-26-23(20)29-21)19-11-16(25)3-4-22(19)33-2/h3-6,8,11-14H,7,9-10H2,1-2H3,(H,26,29)(H,28,32) HZFFZBYHACEEHO-UHFFFAOYSA-N 167737 US9073922, 225::US9796708, Example 225 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167737&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413514 312321581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696362 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)=O)CC1 InChI=1S/C21H20FN3O3/c1-28-19-3-2-14(22)10-16(19)15-4-7-23-21-17(15)11-18(24-21)13-5-8-25(9-6-13)12-20(26)27/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,23,24)(H,26,27) POISLEHCMDEHNV-UHFFFAOYSA-N 167738 US9073922, 226::US9796708, Example 226 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167738&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412012 312321582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696363 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(N)=O)CC1 InChI=1S/C21H21FN4O2/c1-28-19-3-2-14(22)10-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-26(9-6-13)12-20(23)27/h2-5,7,10-11H,6,8-9,12H2,1H3,(H2,23,27)(H,24,25) HIRDTWFIJMZJPT-UHFFFAOYSA-N 167739 US9073922, 227::US9796708, Example 227 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167739&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414336 312321583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696364 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H23FN4O5S/c1-3-32-22(28)26-33(29,30)27-10-7-14(8-11-27)19-13-18-16(6-9-24-21(18)25-19)17-12-15(23)4-5-20(17)31-2/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,24,25)(H,26,28) KUIZXTKIHUHQND-UHFFFAOYSA-N 351938 US9796708, Example 228::ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208035 386046346 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696365 CNC(=O)N1CCC(=CC1)c1cc2c(c(Cl)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H20ClFN4O2/c1-24-21(28)27-7-5-12(6-8-27)17-10-15-19(16(22)11-25-20(15)26-17)14-9-13(23)3-4-18(14)29-2/h3-5,9-11H,6-8H2,1-2H3,(H,24,28)(H,25,26) LHJMUPAYYUKYOW-UHFFFAOYSA-N 167741 US9073922, 229::US9796708, Example 229 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 101 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167741&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414070 312321585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696366 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=N)=O 351940 4-(5-fluoro-2-methoxyphenyl)-2-[1-(S-methylsulfonimidoyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 230 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897268 386046348 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696367 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H24F2N4O2/c1-28(2)21(30)13-29-8-6-14(7-9-29)19-11-17-22(18(25)12-26-23(17)27-19)16-10-15(24)4-5-20(16)31-3/h4-6,10-12H,7-9,13H2,1-3H3,(H,26,27) DQKFBJJSUSQSFP-UHFFFAOYSA-N 167742 US9073922, 231::US9796708, Example 231 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167742&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90415025 312321586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696368 CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)c(F)cc1OC InChI=1S/C21H20F2N4O2/c1-24-21(28)27-7-4-12(5-8-27)18-10-15-13(3-6-25-20(15)26-18)14-9-16(22)17(23)11-19(14)29-2/h3-4,6,9-11H,5,7-8H2,1-2H3,(H,24,28)(H,25,26) TTYDKFHHMRKUNP-UHFFFAOYSA-N 167743 US9073922, 232::US9796708, Example 232 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167743&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412799 312321587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696369 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N(C)C 60458 US9073922, 233::US9796708, Example 233 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 114 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412813 313362590 ZINC13122024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696370 CN(C)C(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(F)c1F InChI=1S/C22H22F2N4O/c1-27(2)20(29)13-28-10-7-14(8-11-28)19-12-17-15(6-9-25-22(17)26-19)16-4-3-5-18(23)21(16)24/h3-7,9,12H,8,10-11,13H2,1-2H3,(H,25,26) RWAFBHKTQOMMGW-UHFFFAOYSA-N 167744 US9073922, 234::US9796708, Example 234 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167744&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412283 312321588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696371 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H27FN4O2/c1-27(2)22(29)14-28-10-7-15(8-11-28)20-13-19-17(6-9-25-23(19)26-20)18-12-16(24)4-5-21(18)30-3/h4-6,9,12-13,15H,7-8,10-11,14H2,1-3H3,(H,25,26) OYNCFAQASYCUJL-UHFFFAOYSA-N 167745 US9073922, 235::US9796708, Example 235 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167745&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411285 312321589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696372 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)CC1)C#N InChI=1S/C24H24FN5O2/c1-29(2)22(31)14-30-8-6-15(7-9-30)20-11-19-23(16(12-26)13-27-24(19)28-20)18-10-17(25)4-5-21(18)32-3/h4-6,10-11,13H,7-9,14H2,1-3H3,(H,27,28) JAQCYGSFPFFKQM-UHFFFAOYSA-N 167746 US9073922, 236::US9796708, Example 236 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 126 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167746&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412797 312321590 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696373 CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1cc2c(c(F)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H22F2N4O5S/c1-3-33-22(29)27-34(30,31)28-8-6-13(7-9-28)18-11-16-20(17(24)12-25-21(16)26-18)15-10-14(23)4-5-19(15)32-2/h4-6,10-12H,3,7-9H2,1-2H3,(H,25,26)(H,27,29) KASPLZWJYIMPTQ-UHFFFAOYSA-N 351948 US9796708, Example 237::ethyl ({4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208036 386046356 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696374 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C24H25FN4O3/c1-32-22-3-2-16(25)10-19(22)18-4-7-26-24-20(18)11-21(27-24)15-5-8-28(9-6-15)14-23(31)29-12-17(30)13-29/h2-5,7,10-11,17,30H,6,8-9,12-14H2,1H3,(H,26,27) HBKIZXJUHANRFK-UHFFFAOYSA-N 167748 US9073922, 238::US9796708, Example 238 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167748&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412714 312321592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696375 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C26H29FN4O3/c1-34-24-5-4-18(27)13-21(24)20-6-9-28-26-22(20)14-23(29-26)17-7-11-30(12-8-17)15-25(33)31-10-2-3-19(31)16-32/h4-7,9,13-14,19,32H,2-3,8,10-12,15-16H2,1H3,(H,28,29)/t19-/m0/s1 JLTPEPZBLJDIDW-IBGZPJMESA-N 167749 US9073922, 239::US9796708, Example 239 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167749&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412003 312321593 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696376 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)[C@H]1C[C@@H](O)CN1 InChI=1S/C24H25FN4O3/c1-32-22-3-2-15(25)10-18(22)17-4-7-26-23-19(17)12-20(28-23)14-5-8-29(9-6-14)24(31)21-11-16(30)13-27-21/h2-5,7,10,12,16,21,27,30H,6,8-9,11,13H2,1H3,(H,26,28)/t16-,21-/m1/s1 AWSPBNDPIYXQST-IIBYNOLFSA-N 167750 US9073922, 240::US9796708, Example 240 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167750&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412663 312321594 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696377 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@H](C(C)C)C(O)=O InChI=1S/C25H28FN3O3/c1-14(2)23(25(30)31)28-17-7-4-15(5-8-17)21-13-20-18(10-11-27-24(20)29-21)19-12-16(26)6-9-22(19)32-3/h4,6,9-14,17,23,28H,5,7-8H2,1-3H3,(H,27,29)(H,30,31)/t17?,23-/m1/s1 VKEWATIKYFEHIF-IRCUZVAFSA-N 167751 US9073922, 241::US9796708, Example 241 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167751&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412628 312321595 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696378 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCC[C@H]1C(O)=O InChI=1S/C25H26FN3O3/c1-32-23-9-6-16(26)13-19(23)18-10-11-27-24-20(18)14-21(28-24)15-4-7-17(8-5-15)29-12-2-3-22(29)25(30)31/h4,6,9-11,13-14,17,22H,2-3,5,7-8,12H2,1H3,(H,27,28)(H,30,31)/t17?,22-/m0/s1 DLCUICWSDXPPLF-UGNFMNBCSA-N 167752 US9073922, 242::US9796708, Example 242 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167752&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413056 312321596 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696379 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NC#N InChI=1S/C21H18FN5O2/c1-29-19-3-2-14(22)10-16(19)15-4-7-24-20-17(15)11-18(26-20)13-5-8-27(9-6-13)21(28)25-12-23/h2-5,7,10-11H,6,8-9H2,1H3,(H,24,26)(H,25,28) MICFOIJVGWISNG-UHFFFAOYSA-N 167753 US9073922, 243::US9796708, Example 243 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167753&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412112 312321597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696380 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1 InChI=1S/C26H28FN5O3/c1-35-23-5-4-17(27)13-19(23)18-6-9-29-26-20(18)14-21(30-26)16-7-11-31(12-8-16)15-24(33)32-10-2-3-22(32)25(28)34/h4-7,9,13-14,22H,2-3,8,10-12,15H2,1H3,(H2,28,34)(H,29,30)/t22-/m0/s1 BCZFIPWHOWKDOP-QFIPXVFZSA-N 167754 US9073922, 244::US9796708, Example 244 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 118 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167754&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412639 312321598 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696381 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(N)=O)CC1 InChI=1S/C21H23FN4O2/c1-28-19-3-2-14(22)10-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-26(9-6-13)12-20(23)27/h2-4,7,10-11,13H,5-6,8-9,12H2,1H3,(H2,23,27)(H,24,25) APWXCXQXZHUHNP-UHFFFAOYSA-N 167755 US9073922, 245::US9796708, Example 245 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167755&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412186 312321599 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696382 CNC(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H25FN4O2/c1-24-21(28)13-27-9-6-14(7-10-27)19-12-18-16(5-8-25-22(18)26-19)17-11-15(23)3-4-20(17)29-2/h3-5,8,11-12,14H,6-7,9-10,13H2,1-2H3,(H,24,28)(H,25,26) IPFRWWMVNGTZLS-UHFFFAOYSA-N 167756 US9073922, 246::US9796708, Example 246 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167756&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412110 312321600 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696383 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C26H31FN4O3/c1-34-24-5-4-18(27)13-21(24)20-6-9-28-26-22(20)14-23(29-26)17-7-11-30(12-8-17)15-25(33)31-10-2-3-19(31)16-32/h4-6,9,13-14,17,19,32H,2-3,7-8,10-12,15-16H2,1H3,(H,28,29)/t19-/m0/s1 VUFDXMUYPNFGNC-IBGZPJMESA-N 167757 US9073922, 247::US9796708, Example 247 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167757&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412265 312321601 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696384 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H19FN4O3S/c1-29-18-4-3-14(22)11-16(18)15-5-8-24-21-19(15)17(12-23)20(25-21)13-6-9-26(10-7-13)30(2,27)28/h3-6,8,11H,7,9-10H2,1-2H3,(H,24,25) JRJSWEIJOPQMNU-UHFFFAOYSA-N 167758 US9073922, 248::US9796708, Example 248 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167758&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413199 312321602 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696385 CNC(=O)N1CCC(=CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1C#N InChI=1S/C22H20FN5O2/c1-25-22(29)28-9-6-13(7-10-28)20-17(12-24)19-15(5-8-26-21(19)27-20)16-11-14(23)3-4-18(16)30-2/h3-6,8,11H,7,9-10H2,1-2H3,(H,25,29)(H,26,27) YYJAVNCRFOEOJV-UHFFFAOYSA-N 167759 US9073922, 249::US9796708, Example 249 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167759&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411758 312321603 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696386 CCOC(=O)NS(=O)(=O)NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 351962 US9796708, Example 250::ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}sulfamoyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208037 386046370 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696387 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)CCO)CC1 InChI=1S/C24H29FN4O3/c1-28(11-12-30)23(31)15-29-9-6-16(7-10-29)21-14-20-18(5-8-26-24(20)27-21)19-13-17(25)3-4-22(19)32-2/h3-5,8,13-14,16,30H,6-7,9-12,15H2,1-2H3,(H,26,27) UFFCHUJEEXCLCR-UHFFFAOYSA-N 167761 US9073922, 251::US9796708, Example 251 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167761&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412172 312321605 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696388 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)NC2CC(O)C2)CC1 InChI=1S/C25H29FN4O3/c1-33-23-3-2-16(26)10-20(23)19-4-7-27-25-21(19)13-22(29-25)15-5-8-30(9-6-15)14-24(32)28-17-11-18(31)12-17/h2-4,7,10,13,15,17-18,31H,5-6,8-9,11-12,14H2,1H3,(H,27,29)(H,28,32) LALJURXWRABUQR-UHFFFAOYSA-N 167762 US9073922, 252::US9796708, Example 252 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167762&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413703 312321606 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696389 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C24H27FN4O3/c1-32-22-3-2-16(25)10-19(22)18-4-7-26-24-20(18)11-21(27-24)15-5-8-28(9-6-15)14-23(31)29-12-17(30)13-29/h2-4,7,10-11,15,17,30H,5-6,8-9,12-14H2,1H3,(H,26,27) KSZCTTRGURPYFL-UHFFFAOYSA-N 167763 US9073922, 253::US9796708, Example 253 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167763&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412893 312321607 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696390 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@H](C(O)=O)C(C)(C)C InChI=1S/C26H30FN3O3/c1-26(2,3)23(25(31)32)29-17-8-5-15(6-9-17)21-14-20-18(11-12-28-24(20)30-21)19-13-16(27)7-10-22(19)33-4/h5,7,10-14,17,23,29H,6,8-9H2,1-4H3,(H,28,30)(H,31,32)/t17?,23-/m1/s1 UGHFHWOVSCTHEQ-IRCUZVAFSA-N 167764 US9073922, 254::US9796708, Example 254 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167764&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411408 312321608 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696391 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H26F2N4O2/c1-28(2)21(30)13-29-8-6-14(7-9-29)19-11-17-22(18(25)12-26-23(17)27-19)16-10-15(24)4-5-20(16)31-3/h4-5,10-12,14H,6-9,13H2,1-3H3,(H,26,27) NUBIHPPWKVQBDL-UHFFFAOYSA-N 167765 US9073922, 255::US9796708, Example 255 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167765&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412429 312321609 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696392 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H24FN5O2/c1-29(2)21(31)14-30-10-7-15(8-11-30)23-19(13-26)22-17(6-9-27-24(22)28-23)18-12-16(25)4-5-20(18)32-3/h4-7,9,12H,8,10-11,14H2,1-3H3,(H,27,28) SPURLBKSRVAAPB-UHFFFAOYSA-N 167766 US9073922, 256::US9796708, Example 256 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167766&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412880 312321610 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696393 COc1ccccc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C23H28N4O2/c1-26(2)22(28)15-27-12-9-16(10-13-27)20-14-19-17(8-11-24-23(19)25-20)18-6-4-5-7-21(18)29-3/h4-8,11,14,16H,9-10,12-13,15H2,1-3H3,(H,24,25) IDGXENIAWADDLS-UHFFFAOYSA-N 167767 US9073922, 257::US9796708, Example 257 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167767&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411783 312321611 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696394 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](C)N(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-13-10-14(7-9-25(13)29(3,26)27)19-12-18-16(6-8-23-21(18)24-19)17-11-15(22)4-5-20(17)28-2/h4-6,8,10-13H,7,9H2,1-3H3,(H,23,24)/t13-/m0/s1 PISSTPZYODNWFP-ZDUSSCGKSA-N 167768 US9073922, 258::US9796708, Example 258 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167768&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413141 312321612 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696395 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C24H26F2N4O3/c1-33-21-3-2-15(25)8-17(21)23-18-9-20(28-24(18)27-10-19(23)26)14-4-6-29(7-5-14)13-22(32)30-11-16(31)12-30/h2-3,8-10,14,16,31H,4-7,11-13H2,1H3,(H,27,28) FDOWFKPWAZQJGE-UHFFFAOYSA-N 167769 US9073922, 259::US9796708, Example 259 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 102 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167769&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412618 312321613 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696396 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)[C@H](CO)C1 InChI=1S/C24H27FN4O3/c1-28(2)23(31)13-29-9-7-15(10-17(29)14-30)21-12-20-18(6-8-26-24(20)27-21)19-11-16(25)4-5-22(19)32-3/h4-8,11-12,17,30H,9-10,13-14H2,1-3H3,(H,26,27)/t17-/m0/s1 YJWQVMVMQUCUSN-KRWDZBQOSA-N 167770 US9073922, 260::US9796708, Example 260 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 111 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167770&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413798 312321614 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696397 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](CO)N(CC(=O)N(C)C)CC1 InChI=1S/C24H27FN4O3/c1-28(2)23(31)13-29-9-7-15(10-17(29)14-30)21-12-20-18(6-8-26-24(20)27-21)19-11-16(25)4-5-22(19)32-3/h4-6,8,10-12,17,30H,7,9,13-14H2,1-3H3,(H,26,27)/t17-/m0/s1 AIKDWDASBBEXIR-KRWDZBQOSA-N 167771 US9073922, 261::US9796708, Example 261 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167771&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412614 312321615 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696398 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H]2CN(C[C@H]2C1)S(C)(=O)=O InChI=1S/C22H22FN3O3S/c1-29-21-4-3-16(23)9-18(21)17-5-6-24-22-19(17)10-20(25-22)13-7-14-11-26(30(2,27)28)12-15(14)8-13/h3-7,9-10,14-15H,8,11-12H2,1-2H3,(H,24,25)/t14-,15+/m0/s1 QICYVGAJFXLASI-LSDHHAIUSA-N 167772 US9073922, 262::US9796708, Example 262 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167772&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411650 312321616 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696399 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H23F2N5O2/c1-30(2)20(32)13-31-8-6-14(7-9-31)23-17(11-27)22-21(18(26)12-28-24(22)29-23)16-10-15(25)4-5-19(16)33-3/h4-6,10,12H,7-9,13H2,1-3H3,(H,28,29) CPSHEJWHIPDXTC-UHFFFAOYSA-N 167773 US9073922, 263::US9796708, Example 263 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 101 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167773&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412031 312321617 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696400 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H]2CN(C[C@@H]2C1)S(C)(=O)=O InChI=1S/C22H22FN3O3S/c1-29-21-4-3-16(23)9-18(21)17-5-6-24-22-19(17)10-20(25-22)13-7-14-11-26(30(2,27)28)12-15(14)8-13/h3-7,9-10,14-15H,8,11-12H2,1-2H3,(H,24,25)/t14-,15+/m1/s1 QICYVGAJFXLASI-CABCVRRESA-N 351977 4-(5-fluoro-2-methoxyphenyl)-2-((3 aR,6aS)-2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 264 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351977&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420884 386046385 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696401 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H18F2N4O3S/c1-30-17-4-3-13(22)9-14(17)18-16(23)11-25-21-19(18)15(10-24)20(26-21)12-5-7-27(8-6-12)31(2,28)29/h3-5,9,11H,6-8H2,1-2H3,(H,25,26) ZIGBYLXMGSFJFG-UHFFFAOYSA-N 167774 US9073922, 265::US9796708, Example 265 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167774&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413204 312321618 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696402 CNC(=O)N1CCC(=CC1)c1[nH]c2ncc(F)c(-c3cc(F)ccc3OC)c2c1C#N InChI=1S/C22H19F2N5O2/c1-26-22(30)29-7-5-12(6-8-29)20-15(10-25)19-18(16(24)11-27-21(19)28-20)14-9-13(23)3-4-17(14)31-2/h3-5,9,11H,6-8H2,1-2H3,(H,26,30)(H,27,28) SGXOPGIWGKXVNN-UHFFFAOYSA-N 167775 US9073922, 266::US9796708, Example 266 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167775&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411986 312321619 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696403 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H23F2N5O3/c1-35-20-3-2-15(26)8-17(20)22-19(27)10-29-25-23(22)18(9-28)24(30-25)14-4-6-31(7-5-14)13-21(34)32-11-16(33)12-32/h2-4,8,10,16,33H,5-7,11-13H2,1H3,(H,29,30) DIMWAZPRSFTYDZ-UHFFFAOYSA-N 167776 US9073922, 267::US9796708, Example 267 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 135 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167776&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412690 312321620 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696404 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N2CCC[C@@H]2CO)CC1 InChI=1S/C27H27F2N5O3/c1-37-22-5-4-17(28)11-19(22)24-21(29)13-31-27-25(24)20(12-30)26(32-27)16-6-9-33(10-7-16)14-23(36)34-8-2-3-18(34)15-35/h4-6,11,13,18,35H,2-3,7-10,14-15H2,1H3,(H,31,32)/t18-/m1/s1 IOIQAELYWFFXCN-GOSISDBHSA-N 167777 US9073922, 268::US9796708, Example 268 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 149 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167777&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412315 312321621 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696405 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](CO)N(CC(=O)N(C)C)CC1 InChI=1S/C24H27FN4O3/c1-28(2)23(31)13-29-9-7-15(10-17(29)14-30)21-12-20-18(6-8-26-24(20)27-21)19-11-16(25)4-5-22(19)32-3/h4-6,8,10-12,17,30H,7,9,13-14H2,1-3H3,(H,26,27)/t17-/m1/s1 AIKDWDASBBEXIR-QGZVFWFLSA-N 167778 US9073922, 269::US9796708, Example 269 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 115 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167778&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412566 312321622 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696406 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)[C@@H](CO)C1 InChI=1S/C24H27FN4O3/c1-28(2)23(31)13-29-9-7-15(10-17(29)14-30)21-12-20-18(6-8-26-24(20)27-21)19-11-16(25)4-5-22(19)32-3/h4-8,11-12,17,30H,9-10,13-14H2,1-3H3,(H,26,27)/t17-/m1/s1 YJWQVMVMQUCUSN-QGZVFWFLSA-N 167779 US9073922, 270::US9796708, Example 270 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167779&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412419 312321623 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696407 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(C)(C)N(CC1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-22(2)13-14(8-10-26(22)30(4,27)28)19-12-18-16(7-9-24-21(18)25-19)17-11-15(23)5-6-20(17)29-3/h5-7,9,11-13H,8,10H2,1-4H3,(H,24,25) MLBSBKLYMWPTOA-UHFFFAOYSA-N 167780 US9073922, 271::US9796708, Example 271 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 104 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167780&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412546 312321624 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696408 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(C(C)(C)C1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-22(2)13-14(8-10-26(22)30(4,27)28)19-12-18-16(7-9-24-21(18)25-19)17-11-15(23)5-6-20(17)29-3/h5-9,11-12H,10,13H2,1-4H3,(H,24,25) WRIOPYVLALWCGU-UHFFFAOYSA-N 167781 US9073922, 272::US9796708, Example 272 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 122 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167781&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413836 312321625 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696409 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)C(C)(C)C1 InChI=1S/C25H29FN4O2/c1-25(2)14-16(9-11-30(25)15-23(31)29(3)4)21-13-20-18(8-10-27-24(20)28-21)19-12-17(26)6-7-22(19)32-5/h6-10,12-13H,11,14-15H2,1-5H3,(H,27,28) ZWVAYSKSSFNSIF-UHFFFAOYSA-N 167782 US9073922, 273::US9796708, Example 273 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167782&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412454 312321626 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697204 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)OC(=O)NC(C)(C)C 353836 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl tert-butylcarbamate::US9796708, Example 1068 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 370 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353836&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420664 386047569 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697205 COc1ccc(F)cc1-c1c(OC)cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H31FN4O4/c1-35-23-6-5-18(28)12-20(23)26-21-13-22(30-27(21)29-14-24(26)36-2)17-7-10-31(11-8-17)15-25(34)32-9-3-4-19(32)16-33/h5-7,12-14,19,33H,3-4,8-11,15-16H2,1-2H3,(H,29,30)/t19-/m0/s1 PPTRMZDUQKEHNB-IBGZPJMESA-N 353837 2-{4-[4-(5-fluoro-2-methoxyphenyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1069 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 370 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353837&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420774 386047570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697206 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C26H30F2N4O3/c1-35-24-13-22(28)21(27)11-19(24)18-4-7-29-26-20(18)12-23(30-26)16-5-9-31(10-6-16)14-25(34)32-8-2-3-17(32)15-33/h4,7,11-13,16-17,33H,2-3,5-6,8-10,14-15H2,1H3,(H,29,30)/t17-/m0/s1 XQQFDQPJWJLWTJ-KRWDZBQOSA-N 353838 2-{4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1070 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353838&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419764 386047571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697207 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)[C@@H](C)C1 InChI=1S/C24H29FN4O2/c1-15-11-16(8-10-29(15)14-23(30)28(2)3)21-13-20-18(7-9-26-24(20)27-21)19-12-17(25)5-6-22(19)31-4/h5-7,9,12-13,15-16H,8,10-11,14H2,1-4H3,(H,26,27)/t15-,16?/m0/s1 FQOJDVVEFOOBMY-VYRBHSGPSA-N 353839 2-{(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-methylpiperidin-1-yl}-N,N-dimethylacetamide::US9796708, Example 1071 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353839&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419502 386047572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697208 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(CC(F)(F)F)C(O)=O 353840 4,4,4-trifluoro-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}butanoic acid::US9796708, Example 1072 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353840&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897350 386047573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697209 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CS(=O)(=O)N(C)C InChI=1S/C23H25FN4O4S/c1-27(2)33(30,31)14-22(29)28-10-7-15(8-11-28)20-13-19-17(6-9-25-23(19)26-20)18-12-16(24)4-5-21(18)32-3/h4-7,9,12-13H,8,10-11,14H2,1-3H3,(H,25,26) OHFWJDYMLCPQHC-UHFFFAOYSA-N 353841 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethyl-2-oxoethanesulfonamide::US9796708, Example 1073 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353841&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897221 386047574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697210 CNS(=O)(=O)CC(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H25FN4O4S/c1-24-32(29,30)13-21(28)27-9-6-14(7-10-27)19-12-18-16(5-8-25-22(18)26-19)17-11-15(23)3-4-20(17)31-2/h3-5,8,11-12,14,24H,6-7,9-10,13H2,1-2H3,(H,25,26) YKEANJIFLZGBAI-UHFFFAOYSA-N 353842 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methyl-2-oxoethanesulfonamide::US9796708, Example 1074 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353842&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420450 386047575 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697211 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)CS(=O)(=O)N(C)C InChI=1S/C23H27FN4O4S/c1-27(2)33(30,31)14-22(29)28-10-7-15(8-11-28)20-13-19-17(6-9-25-23(19)26-20)18-12-16(24)4-5-21(18)32-3/h4-6,9,12-13,15H,7-8,10-11,14H2,1-3H3,(H,25,26) PZMWYPQXIWUJPS-UHFFFAOYSA-N 353843 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N,N-dimethyl-2-oxoethanesulfonamide::US9796708, Example 1075 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353843&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419845 386047576 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697212 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)C(C)S(N)(=O)=O 353844 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-oxopropane-2-sulfonamide::US9796708, Example 1076 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353844&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897207 386047577 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697213 CCOC(=O)C(N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)c1ccccc1 353845 US9796708, Example 1077::ethyl {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(phenyl)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 760 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353845&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208158 386047578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697214 CCOC(=O)c1cnc(s1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H23FN4O3S/c1-3-33-24(31)22-14-28-25(34-22)30-10-7-15(8-11-30)20-13-19-17(6-9-27-23(19)29-20)18-12-16(26)4-5-21(18)32-2/h4-7,9,12-14H,3,8,10-11H2,1-2H3,(H,27,29) OMOUYUDTRNUNIC-UHFFFAOYSA-N 353846 US9796708, Example 1078::ethyl 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1,3-thiazole-5-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353846&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419824 386047579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697215 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCN(C1)C(=O)OC(C)(C)C 353847 US9796708, Example 1079::tert-butyl 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}pyrrolidine-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353847&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421233 386047580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697216 CCOC(=O)NS(=O)(=O)N1CCC(=C[C@@H]1C)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H25FN4O5S/c1-4-33-23(29)27-34(30,31)28-10-8-15(11-14(28)2)20-13-19-17(7-9-25-22(19)26-20)18-12-16(24)5-6-21(18)32-3/h5-7,9,11-14H,4,8,10H2,1-3H3,(H,25,26)(H,27,29)/t14-/m0/s1 BFAOEZVDIJRAQK-AWEZNQCLSA-N 353848 US9796708, Example 1080::ethyl {[(6S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydropyridin-1(2H)-yl]sulfonyl}carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353848&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208159 386047581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697217 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)OCCO 353849 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}oxy)ethanol::US9796708, Example 1081 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353849&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419689 386047582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697218 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(C)C(O)=O 353850 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}propanoic acid::US9796708, Example 1082 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353850&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419918 386047583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697219 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(C(O)=O)c1ccccc1 353851 US9796708, Example 1083::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(phenyl)acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353851&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419566 386047584 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697220 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCNC1 353852 4-(5-fluoro-2-methoxyphenyl)-2-[1-(pyrrolidin-3-yl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1084 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353852&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897247 386047585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697221 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)C(=O)CC#N InChI=1S/C22H20F2N4O2/c1-30-19-3-2-14(23)10-15(19)21-16-11-18(27-22(16)26-12-17(21)24)13-5-8-28(9-6-13)20(29)4-7-25/h2-3,10-13H,4-6,8-9H2,1H3,(H,26,27) JZUQWOMLSOTVRJ-UHFFFAOYSA-N 353853 3-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-3-oxopropanenitrile::US9796708, Example 1085 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353853&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420808 386047586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697222 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCNCC1 InChI=1S/C20H16F2N4O/c1-27-16-3-2-12(21)8-13(16)17-15(22)10-25-20-18(17)14(9-23)19(26-20)11-4-6-24-7-5-11/h2-4,8,10,24H,5-7H2,1H3,(H,25,26) HHZCMZCQFIOGTR-UHFFFAOYSA-N 353854 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1086 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353854&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412050 386047587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697223 NC(=O)c1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C19H17FN4O/c20-12-1-2-14(18(21)25)15(9-12)13-5-8-23-19-16(13)10-17(24-19)11-3-6-22-7-4-11/h1-3,5,8-10,22H,4,6-7H2,(H2,21,25)(H,23,24) MUEVBGIUHYRLGH-UHFFFAOYSA-N 353855 4-fluoro-2-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzamide::US9796708, Example 1087 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419628 386047588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697224 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC(O)=O)CC1 InChI=1S/C22H18F2N4O3/c1-31-17-3-2-13(23)8-14(17)19-16(24)10-26-22-20(19)15(9-25)21(27-22)12-4-6-28(7-5-12)11-18(29)30/h2-4,8,10H,5-7,11H2,1H3,(H,26,27)(H,29,30) FIZUXKADVVOUPD-UHFFFAOYSA-N 353856 US9796708, Example 1088::{4-[3-cyano-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353856&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412247 386047589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697225 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCCN InChI=1S/C22H24FN5O5S/c1-32-20-3-2-15(23)12-17(20)16-4-8-25-21-18(16)13-19(26-21)14-5-9-28(10-6-14)34(30,31)27-22(29)33-11-7-24/h2-5,8,12-13H,6-7,9-11,24H2,1H3,(H,25,26)(H,27,29) OMOLIRLJLDEJET-UHFFFAOYSA-N 353857 2-aminoethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 1089 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353857&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420186 386047590 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697226 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCC1CNC1 InChI=1S/C24H26FN5O5S/c1-34-22-3-2-17(25)10-19(22)18-4-7-27-23-20(18)11-21(28-23)16-5-8-30(9-6-16)36(32,33)29-24(31)35-14-15-12-26-13-15/h2-5,7,10-11,15,26H,6,8-9,12-14H2,1H3,(H,27,28)(H,29,31) JGTHYASRRJKCLC-UHFFFAOYSA-N 353858 US9796708, Example 1090::azetidin-3-ylmethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353858&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420049 386047591 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697227 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)NC(=O)OCCN(C)C InChI=1S/C24H28FN5O5S/c1-29(2)12-13-35-24(31)28-36(32,33)30-10-7-16(8-11-30)21-15-20-18(6-9-26-23(20)27-21)19-14-17(25)4-5-22(19)34-3/h4-7,9,14-15H,8,10-13H2,1-3H3,(H,26,27)(H,28,31) OGQXPAPAJWBQMQ-UHFFFAOYSA-N 353859 2-(dimethylamino)ethyl ({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)carbamate::US9796708, Example 1091 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353859&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419899 386047592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697228 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNC(C)(C)C1 InChI=1S/C21H22FN3O/c1-21(2)12-13(6-9-24-21)18-11-17-15(7-8-23-20(17)25-18)16-10-14(22)4-5-19(16)26-3/h4-8,10-11,24H,9,12H2,1-3H3,(H,23,25) DNPHPINSFCMQON-UHFFFAOYSA-N 353860 2-(2,2-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1092 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353860&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412266 386047593 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697229 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(O)=O)CC3)c(C#N)c12 InChI=1S/C22H21FN4O3/c1-30-18-3-2-14(23)10-16(18)15-4-7-25-22-20(15)17(11-24)21(26-22)13-5-8-27(9-6-13)12-19(28)29/h2-4,7,10,13H,5-6,8-9,12H2,1H3,(H,25,26)(H,28,29) VMAHADVDDPZDHO-UHFFFAOYSA-N 353861 US9796708, Example 1093::{4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353861&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897387 386047594 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697230 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3)c(C#N)c12 InChI=1S/C20H19FN4O/c1-26-17-3-2-13(21)10-15(17)14-6-9-24-20-18(14)16(11-22)19(25-20)12-4-7-23-8-5-12/h2-3,6,9-10,12,23H,4-5,7-8H2,1H3,(H,24,25) OHUKHSZDFITAGY-UHFFFAOYSA-N 353862 4-(5-fluoro-2-methoxyphenyl)-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1094 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353862&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420195 386047595 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697231 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)N(C)C)CC3)c(C#N)c12 InChI=1S/C24H26FN5O2/c1-29(2)21(31)14-30-10-7-15(8-11-30)23-19(13-26)22-17(6-9-27-24(22)28-23)18-12-16(25)4-5-20(18)32-3/h4-6,9,12,15H,7-8,10-11,14H2,1-3H3,(H,27,28) OYDYRJKIPLZQPW-UHFFFAOYSA-N 353863 2-{4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N,N-dimethylacetamide::US9796708, Example 1095 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353863&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420638 386047596 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697232 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2n[nH]c(=O)[nH]2)CC1 InChI=1S/C22H23FN6O2/c1-31-19-3-2-14(23)10-16(19)15-4-7-24-21-17(15)11-18(25-21)13-5-8-29(9-6-13)12-20-26-22(30)28-27-20/h2-4,7,10-11,13H,5-6,8-9,12H2,1H3,(H,24,25)(H2,26,27,28,30) FHYIVJUERNRMIK-UHFFFAOYSA-N 353864 5-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one::US9796708, Example 1096 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353864&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208160 386047597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697233 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCN(C1)S(C)(=O)=O 353865 4-(5-fluoro-2-methoxyphenyl)-2-{1-[1-(methylsulfonyl)pyrrolidin-3-yl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1097 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353865&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897286 386047598 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697234 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)NS(=O)(=O)C(C)C)CC1 InChI=1S/C24H29FN4O4S/c1-15(2)34(31,32)28-23(30)14-29-10-7-16(8-11-29)21-13-20-18(6-9-26-24(20)27-21)19-12-17(25)4-5-22(19)33-3/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3,(H,26,27)(H,28,30) BCXWNNFZNLDSJX-UHFFFAOYSA-N 353866 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-(propan-2-ylsulfonyl)acetamide::US9796708, Example 1098 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353866&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420126 386047599 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697235 CCOC(=O)c1cnc(s1)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H25FN4O3S/c1-3-33-24(31)22-14-28-25(34-22)30-10-7-15(8-11-30)20-13-19-17(6-9-27-23(19)29-20)18-12-16(26)4-5-21(18)32-2/h4-6,9,12-15H,3,7-8,10-11H2,1-2H3,(H,27,29) WGHABYBHSTZPTM-UHFFFAOYSA-N 353867 US9796708, Example 1099::ethyl 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1,3-thiazole-5-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353867&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421471 386047600 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697236 COC(=O)CC1CCC(CC1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C28H32FN3O3/c1-34-26-8-5-20(29)16-23(26)22-9-12-30-28-24(22)17-25(31-28)19-10-13-32(14-11-19)21-6-3-18(4-7-21)15-27(33)35-2/h5,8-10,12,16-18,21H,3-4,6-7,11,13-15H2,1-2H3,(H,30,31) VXHJMEPKWSABIL-UHFFFAOYSA-N 353868 US9796708, Example 1100::methyl (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353868&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414211 386047601 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697237 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCN(C)C1=O 353869 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-methylpyrrolidin-2-one::US9796708, Example 1101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353869&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419534 386047602 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697238 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CNC(=O)C1 353870 4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}pyrrolidin-2-one::US9796708, Example 1102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353870&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420578 386047603 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697239 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)c1ncc(s1)C(O)=O InChI=1S/C23H21FN4O3S/c1-31-19-3-2-14(24)10-16(19)15-4-7-25-21-17(15)11-18(27-21)13-5-8-28(9-6-13)23-26-12-20(32-23)22(29)30/h2-4,7,10-13H,5-6,8-9H2,1H3,(H,25,27)(H,29,30) DOTNVWLQINTNBI-UHFFFAOYSA-N 353871 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1,3-thiazole-5-carboxylic acid::US9796708, Example 1103 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353871&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420618 386047604 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697240 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](C1CCCCC1)C(O)=O InChI=1S/C28H32FN3O3/c1-35-25-12-9-19(29)15-22(25)21-13-14-30-27-23(21)16-24(32-27)17-7-10-20(11-8-17)31-26(28(33)34)18-5-3-2-4-6-18/h7,9,12-16,18,20,26,31H,2-6,8,10-11H2,1H3,(H,30,32)(H,33,34)/t20?,26-/m0/s1 KMFCSKXWGKRTHI-GHZUAHJPSA-N 353872 (2S)-cyclohexyl({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}amino)acetic acid::US9796708, Example 1104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353872&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420644 386047605 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697241 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC1)N[C@H](C(C)C)C(O)=O InChI=1S/C25H27F2N3O3/c1-13(2)23(25(31)32)29-16-7-4-14(5-8-16)20-11-18-22(19(27)12-28-24(18)30-20)17-10-15(26)6-9-21(17)33-3/h4,6,9-13,16,23,29H,5,7-8H2,1-3H3,(H,28,30)(H,31,32)/t16?,23-/m1/s1 LVYXXRKBGZQEJJ-IJBYHRAESA-N 353873 N-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-D-valine::US9796708, Example 1105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353873&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420326 386047606 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697242 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC1)N[C@H](C(O)=O)C(C)(C)C InChI=1S/C26H29F2N3O3/c1-26(2,3)23(25(32)33)30-16-8-5-14(6-9-16)20-12-18-22(19(28)13-29-24(18)31-20)17-11-15(27)7-10-21(17)34-4/h5,7,10-13,16,23,30H,6,8-9H2,1-4H3,(H,29,31)(H,32,33)/t16?,23-/m1/s1 WUNAMZVLXKPXGQ-IJBYHRAESA-N 353874 N-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-3-methyl-L-valine::US9796708, Example 1106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353874&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420700 386047607 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697243 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H27F2N5O3/c1-37-22-5-4-17(28)11-19(22)24-21(29)13-31-27-25(24)20(12-30)26(32-27)16-6-9-33(10-7-16)14-23(36)34-8-2-3-18(34)15-35/h4-6,11,13,18,35H,2-3,7-10,14-15H2,1H3,(H,31,32)/t18-/m0/s1 IOIQAELYWFFXCN-SFHVURJKSA-N 353875 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353875&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419572 386047608 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697244 COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC3)S(C)(=O)=O)c(C#N)c12 InChI=1S/C21H21FN4O3S/c1-29-18-4-3-14(22)11-16(18)15-5-8-24-21-19(15)17(12-23)20(25-21)13-6-9-26(10-7-13)30(2,27)28/h3-5,8,11,13H,6-7,9-10H2,1-2H3,(H,24,25) HOXPAWCKQNNZPX-UHFFFAOYSA-N 353876 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353876&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420648 386047609 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697245 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(O)=O)CC1 InChI=1S/C21H21F2N3O3/c1-29-18-3-2-13(22)8-14(18)20-15-9-17(25-21(15)24-10-16(20)23)12-4-6-26(7-5-12)11-19(27)28/h2-3,8-10,12H,4-7,11H2,1H3,(H,24,25)(H,27,28) MBPHUSJYHDMEKJ-UHFFFAOYSA-N 353877 US9796708, Example 1109::{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353877&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414223 386047610 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697246 COC(=O)[C@@H]1CCCN1C(=O)C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C27H28FN3O4/c1-34-24-10-9-18(28)14-20(24)19-11-12-29-25-21(19)15-22(30-25)16-5-7-17(8-6-16)26(32)31-13-3-4-23(31)27(33)35-2/h5,9-12,14-15,17,23H,3-4,6-8,13H2,1-2H3,(H,29,30)/t17?,23-/m0/s1 MNPRMUJMPKOGGT-VXLWULRPSA-N 353878 US9796708, Example 1110::methyl 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}carbonyl)prolinate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 187 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897209 386047611 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697247 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC1)C(=O)NC#N InChI=1S/C22H16F2N6O2/c1-32-17-3-2-13(23)8-14(17)18-16(24)10-27-21-19(18)15(9-25)20(29-21)12-4-6-30(7-5-12)22(31)28-11-26/h2-4,8,10H,5-7H2,1H3,(H,27,29)(H,28,31) FEKLZMCAEWSYRS-UHFFFAOYSA-N 353879 N-cyano-4-[3-cyano-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 1111 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353879&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419946 386047612 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697248 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(CC(O)=O)CC1 InChI=1S/C27H30FN3O3/c1-34-25-7-4-19(28)15-22(25)21-8-11-29-27-23(21)16-24(30-27)18-9-12-31(13-10-18)20-5-2-17(3-6-20)14-26(32)33/h4,7-9,11,15-17,20H,2-3,5-6,10,12-14H2,1H3,(H,29,30)(H,32,33) DZZGVCFHAAYUAE-UHFFFAOYSA-N 353880 (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)acetic acid::US9796708, Example 1112 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353880&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search YOS 7M2F 90411536 386047613 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697249 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C1CCN(C)C1=O 353881 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-methylpyrrolidin-2-one::US9796708, Example 1113 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 840 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353881&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420024 386047614 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697250 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NC#N InChI=1S/C21H17F2N5O2/c1-30-18-3-2-13(22)8-14(18)19-15-9-17(27-20(15)25-10-16(19)23)12-4-6-28(7-5-12)21(29)26-11-24/h2-4,8-10H,5-7H2,1H3,(H,25,27)(H,26,29) NLLJPNLEHKBAKJ-UHFFFAOYSA-N 353882 N-cyano-4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 1114 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353882&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420079 386047615 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697251 COCCOCCS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C24H28FN3O5S/c1-31-11-12-33-13-14-34(29,30)28-9-6-17(7-10-28)22-16-21-19(5-8-26-24(21)27-22)20-15-18(25)3-4-23(20)32-2/h3-6,8,15-16H,7,9-14H2,1-2H3,(H,26,27) HOBBFJTXPZTWBW-UHFFFAOYSA-N 353883 4-(5-fluoro-2-methoxyphenyl)-2-(1-{[2-(2-methoxyethoxy)ethyl]sulfonyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1115 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420453 386047616 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697252 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1 InChI=1S/C27H26F2N6O3/c1-38-21-5-4-16(28)11-17(21)23-19(29)13-32-27-24(23)18(12-30)25(33-27)15-6-9-34(10-7-15)14-22(36)35-8-2-3-20(35)26(31)37/h4-6,11,13,20H,2-3,7-10,14H2,1H3,(H2,31,37)(H,32,33)/t20-/m0/s1 UJEDRLIFWABEQA-FQEVSTJZSA-N 353884 1-({4-[3-cyano-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetyl)-L-prolinamide::US9796708, Example 1116 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 115 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353884&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420743 386047617 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697253 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)NC#N)CC1 InChI=1S/C22H22FN5O2/c1-30-20-3-2-15(23)10-17(20)16-4-7-25-22-18(16)11-19(27-22)14-5-8-28(9-6-14)12-21(29)26-13-24/h2-4,7,10-11,14H,5-6,8-9,12H2,1H3,(H,25,27)(H,26,29) BCGQYCBBSGSWAW-UHFFFAOYSA-N 353885 N-cyano-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetamide::US9796708, Example 1117 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897214 386047618 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697254 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](CO)NCC1 InChI=1S/C20H20FN3O2/c1-26-19-3-2-13(21)9-16(19)15-5-7-23-20-17(15)10-18(24-20)12-4-6-22-14(8-12)11-25/h2-3,5,7-10,14,22,25H,4,6,11H2,1H3,(H,23,24)/t14-/m1/s1 AOXMZOYTPIOGHV-CQSZACIVSA-N 353886 US9796708, Example 1118::{(2R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,5,6-tetrahydropyridin-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353886&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420886 386047619 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697255 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN[C@@H](CO)C1 InChI=1S/C20H20FN3O2/c1-26-19-3-2-13(21)9-16(19)15-5-7-23-20-17(15)10-18(24-20)12-4-6-22-14(8-12)11-25/h2-5,7,9-10,14,22,25H,6,8,11H2,1H3,(H,23,24)/t14-/m1/s1 WTCATEFCXLZNCB-CQSZACIVSA-N 353887 US9796708, Example 1119::{(2R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,6-tetrahydropyridin-2-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353887&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421192 386047620 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696410 COCCS(=O)(=O)N1CC2CC(=CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 167783 US9073922, 274::US9796708, Example 274 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167783&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412224 312321627 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696411 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1)C#N InChI=1S/C24H26FN5O2/c1-29(2)22(31)14-30-8-6-15(7-9-30)20-11-19-23(16(12-26)13-27-24(19)28-20)18-10-17(25)4-5-21(18)32-3/h4-5,10-11,13,15H,6-9,14H2,1-3H3,(H,27,28) NDTXKBSFGOQMPJ-UHFFFAOYSA-N 167784 US9073922, 275::US9796708, Example 275 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167784&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413089 312321628 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696412 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C2CC(O)C2)CC1 InChI=1S/C26H31FN4O3/c1-30(18-12-19(32)13-18)25(33)15-31-9-6-16(7-10-31)23-14-22-20(5-8-28-26(22)29-23)21-11-17(27)3-4-24(21)34-2/h3-5,8,11,14,16,18-19,32H,6-7,9-10,12-13,15H2,1-2H3,(H,28,29) LLXWHPDUOATKLG-UHFFFAOYSA-N 167785 US9073922, 276::US9796708, Example 276 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167785&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412633 312321629 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696413 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O)C#N 167786 US9073922, 277::US9796708, Example 277 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167786&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413677 312321630 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696414 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)C)CC2C1)C#N 167787 US9073922, 278::US9796708, Example 278 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167787&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412013 312321631 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696415 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 167788 US9073922, 279::US9796708, Example 279 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 124 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167788&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412334 312321632 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696416 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)CO 167789 US9073922, 280::US9796708, Example 280 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167789&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412531 312321633 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696417 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)CC#N 167790 US9073922, 281::US9796708, Example 281 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167790&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412583 312321634 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696418 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O 167791 US9073922, 282::US9796708, Example 282 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 117 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167791&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412270 312321635 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696419 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1)C#N InChI=1S/C27H28FN5O3/c1-36-24-5-4-19(28)11-21(24)26-18(13-29)14-30-27-22(26)12-23(31-27)17-6-9-32(10-7-17)15-25(35)33-8-2-3-20(33)16-34/h4-6,11-12,14,20,34H,2-3,7-10,15-16H2,1H3,(H,30,31)/t20-/m0/s1 CPTRVJYZQWEORK-FQEVSTJZSA-N 167792 US9073922, 283::US9796708, Example 283 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 172 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167792&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412367 312321636 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696420 CNC(=O)N1C[C@@H]2CC(=C[C@@H]2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H23FN4O2/c1-25-23(29)28-11-14-7-13(8-15(14)12-28)20-10-19-17(5-6-26-22(19)27-20)18-9-16(24)3-4-21(18)30-2/h3-7,9-10,14-15H,8,11-12H2,1-2H3,(H,25,29)(H,26,27)/t14-,15+/m1/s1 ZGPFCXBCLXQLOM-CABCVRRESA-N 167793 US9073922, 284::US9796708, Example 284 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167793&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412877 312321637 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696421 CNC(=O)N1C[C@H]2CC(=C[C@H]2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H23FN4O2/c1-25-23(29)28-11-14-7-13(8-15(14)12-28)20-10-19-17(5-6-26-22(19)27-20)18-9-16(24)3-4-21(18)30-2/h3-7,9-10,14-15H,8,11-12H2,1-2H3,(H,25,29)(H,26,27)/t14-,15+/m0/s1 ZGPFCXBCLXQLOM-LSDHHAIUSA-N 167794 US9073922, 285::US9796708, Example 285 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167794&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413879 312321638 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696422 CNC(=O)N1CC2CC(=CC2C1)c1cc2c(c(F)cnc2[nH]1)-c1cc(F)ccc1OC 167795 US9073922, 286::US9796708, Example 286 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 201 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167795&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412260 312321639 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696423 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)C)CC2C1 167796 US9073922, 287::US9796708, Example 287 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 104 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167796&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413864 312321640 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696424 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 InChI=1S/C27H30FN3O3/c1-34-25-7-4-19(28)15-22(25)21-8-11-29-27-23(21)16-24(30-27)18-9-12-31(13-10-18)20-5-2-17(3-6-20)14-26(32)33/h4,7-9,11,15-17,20H,2-3,5-6,10,12-14H2,1H3,(H,29,30)(H,32,33)/t17-,20+ DZZGVCFHAAYUAE-MSEWRSJXSA-N 167797 US9073922, 288::US9796708, Example 288 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167797&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411536 312321641 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696425 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 InChI=1S/C27H30FN3O3/c1-34-25-7-4-19(28)15-22(25)21-8-11-29-27-23(21)16-24(30-27)18-9-12-31(13-10-18)20-5-2-17(3-6-20)14-26(32)33/h4,7-9,11,15-17,20H,2-3,5-6,10,12-14H2,1H3,(H,29,30)(H,32,33)/t17-,20- DZZGVCFHAAYUAE-IRJFHVNHSA-N 167798 US9073922, 289::US9796708, Example 289 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167798&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search YOS 7M2F 90411536 312321642 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696426 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1)C#N InChI=1S/C27H30FN5O3/c1-36-24-5-4-19(28)11-21(24)26-18(13-29)14-30-27-22(26)12-23(31-27)17-6-9-32(10-7-17)15-25(35)33-8-2-3-20(33)16-34/h4-5,11-12,14,17,20,34H,2-3,6-10,15-16H2,1H3,(H,30,31)/t20-/m0/s1 LKRMXRXVKMFHRU-FQEVSTJZSA-N 167799 US9073922, 290::US9796708, Example 290 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167799&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413120 312321643 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696427 CNS(=O)(=O)CC(=O)N1CC2CC(=CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 167800 US9073922, 291::US9796708, Example 291 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167800&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412105 312321644 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696428 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(CC1)C(O)=O InChI=1S/C26H28FN3O3/c1-33-24-7-4-18(27)14-21(24)20-8-11-28-25-22(20)15-23(29-25)16-9-12-30(13-10-16)19-5-2-17(3-6-19)26(31)32/h4,7-9,11,14-15,17,19H,2-3,5-6,10,12-13H2,1H3,(H,28,29)(H,31,32) JQQQJMZBOAYKKR-UHFFFAOYSA-N 167801 US9073922, 292::US9796708, Example 292 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 139 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167801&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412403 312321645 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696429 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N3CC(O)C3)CC2C1 167802 US9073922, 293::US9796708, Example 293 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167802&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90415170 312321646 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696430 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C24H24F2N4O3/c1-33-21-3-2-15(25)8-17(21)23-18-9-20(28-24(18)27-10-19(23)26)14-4-6-29(7-5-14)13-22(32)30-11-16(31)12-30/h2-4,8-10,16,31H,5-7,11-13H2,1H3,(H,27,28) ZEZFOLKGMPPLQJ-UHFFFAOYSA-N 167803 US9073922, 294::US9796708, Example 294 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167803&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413158 312321647 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696431 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(=O)N3CC(O)C3)CC2C1 167804 US9073922, 295::US9796708, Example 295 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 119 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167804&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413574 312321648 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696432 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(=O)N3CCC[C@H]3CO)CC2C1 InChI=1S/C28H31FN4O3/c1-36-26-5-4-20(29)11-23(26)22-6-7-30-28-24(22)12-25(31-28)17-9-18-13-32(14-19(18)10-17)15-27(35)33-8-2-3-21(33)16-34/h4-7,9,11-12,18-19,21,34H,2-3,8,10,13-16H2,1H3,(H,30,31)/t18?,19?,21-/m0/s1 WIEDXTFTBPGHBX-GRERDSQWSA-N 167805 US9073922, 296::US9796708, Example 296 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 125 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167805&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412597 312321649 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696433 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC(O)CC2)CC1 InChI=1S/C26H28F2N4O3/c1-35-23-3-2-17(27)12-19(23)25-20-13-22(30-26(20)29-14-21(25)28)16-4-8-31(9-5-16)15-24(34)32-10-6-18(33)7-11-32/h2-4,12-14,18,33H,5-11,15H2,1H3,(H,29,30) JSQOGXIYSSITIT-UHFFFAOYSA-N 167806 US9073922, 297::US9796708, Example 297 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167806&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413932 312321650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696434 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(CC(O)=O)CC1 InChI=1S/C27H29F2N3O3/c1-35-24-7-4-18(28)13-20(24)26-21-14-23(31-27(21)30-15-22(26)29)17-8-10-32(11-9-17)19-5-2-16(3-6-19)12-25(33)34/h4,7-8,13-16,19H,2-3,5-6,9-12H2,1H3,(H,30,31)(H,33,34) DIJOGBQYCAXFRN-UHFFFAOYSA-N 167807 US9073922, 298::US9796708, Example 298 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167807&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413177 312321651 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696435 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(O)C2)C(C)(C)C1 InChI=1S/C26H29FN4O3/c1-26(2)12-16(7-9-31(26)15-24(33)30-13-18(32)14-30)22-11-21-19(6-8-28-25(21)29-22)20-10-17(27)4-5-23(20)34-3/h4-8,10-11,18,32H,9,12-15H2,1-3H3,(H,28,29) RRUJVLAWHSEHCI-UHFFFAOYSA-N 167808 US9073922, 299::US9796708, Example 299 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167808&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412316 312321652 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696436 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)C1CC(O)C1 167809 US9073922, 300::US9796708, Example 300 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 115 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167809&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412440 312321653 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696437 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N(C)C)C#N 60460 US9073922, 301::US9796708, Example 301 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412559 313362592 ZINC03312258 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696438 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N(C)C 60461 US9073922, 302::US9796708, Example 302 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60461&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412047 313362593 ZINC13125086 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696439 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N3CCC[C@H]3CO)CC2C1)C#N InChI=1S/C29H30FN5O3/c1-38-26-5-4-21(30)9-23(26)28-20(11-31)12-32-29-24(28)10-25(33-29)17-7-18-13-34(14-19(18)8-17)15-27(37)35-6-2-3-22(35)16-36/h4-5,7,9-10,12,18-19,22,36H,2-3,6,8,13-16H2,1H3,(H,32,33)/t18?,19?,22-/m0/s1 RSTIWHPPSZINQJ-AJTFCVKESA-N 167810 US9073922, 303::US9796708, Example 303 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 138 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167810&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413281 312321654 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696440 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N1CC(O)C1 353072 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 304 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 131 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353072&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411842 386046811 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696441 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N1CCC[C@H]1CO InChI=1S/C28H31FN4O3/c1-36-26-7-4-18(29)13-23(26)22-8-9-30-28-24(22)14-25(31-28)17-11-19-5-6-20(12-17)33(19)15-27(35)32-10-2-3-21(32)16-34/h4,7-9,11,13-14,19-21,34H,2-3,5-6,10,12,15-16H2,1H3,(H,30,31)/t19?,20?,21-/m0/s1 HSHODAPNCGQCNZ-CBNMVNINSA-N 353073 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 305 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353073&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412272 386046812 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696442 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N(C)CCO 60465 US9073922, 306::US9796708, Example 306 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 114 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60465&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413268 313362596 ZINC15974559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696443 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccccc2)ccc1F InChI=1S/C26H27FN4/c1-31-13-10-19(11-14-31)25-16-23-21(9-12-28-26(23)30-25)22-15-20(7-8-24(22)27)29-17-18-5-3-2-4-6-18/h2-9,12,15-16,19,29H,10-11,13-14,17H2,1H3,(H,28,30) CIRIMSUYTATOLF-UHFFFAOYSA-N 353075 N-benzyl-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]anilin::US9796708, Example 307 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353075&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420539 386046814 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696444 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(O)cc2)ccc1F InChI=1S/C26H27FN4O/c1-31-12-9-18(10-13-31)25-15-23-21(8-11-28-26(23)30-25)22-14-19(4-7-24(22)27)29-16-17-2-5-20(32)6-3-17/h2-8,11,14-15,18,29,32H,9-10,12-13,16H2,1H3,(H,28,30) UOOCHPDNJPKJRC-UHFFFAOYSA-N 353076 4-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]phenol::US9796708, Example 308 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353076&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419897 386046815 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696445 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ncn[nH]2)ccc1F InChI=1S/C22H24FN7/c1-30-8-5-14(6-9-30)20-11-18-16(4-7-24-22(18)28-20)17-10-15(2-3-19(17)23)25-12-21-26-13-27-29-21/h2-4,7,10-11,13-14,25H,5-6,8-9,12H2,1H3,(H,24,28)(H,26,27,29) VBZHPXQNWUIIRU-UHFFFAOYSA-N 353077 4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1H-1,2,4-triazol-5-ylmethyl) aniline::US9796708, Example 309 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353077&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421068 386046816 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696446 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccccn2)ccc1F InChI=1S/C25H26FN5/c1-31-12-8-17(9-13-31)24-15-22-20(7-11-28-25(22)30-24)21-14-18(5-6-23(21)26)29-16-19-4-2-3-10-27-19/h2-7,10-11,14-15,17,29H,8-9,12-13,16H2,1H3,(H,28,30) FMJZSVCRHASPLA-UHFFFAOYSA-N 353078 4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(pyridin-2-ylmethyl)aniline::US9796708, Example 310 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353078&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419999 386046817 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696447 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCC2CCOC(C)(C)C2)ccc1F 353079 N-[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl]-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 311 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353079&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420358 386046818 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696448 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(ccc1F)N(CC1CCOC(C)(C)C1)CC1CCOC(C)(C)C1 353080 N,N-bis[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl]-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 312 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1400 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353080&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420282 386046819 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696449 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(ccc1F)N(CC1CC1)CC1CC1 InChI=1S/C27H33FN4/c1-31-12-9-20(10-13-31)26-15-24-22(8-11-29-27(24)30-26)23-14-21(6-7-25(23)28)32(16-18-2-3-18)17-19-4-5-19/h6-8,11,14-15,18-20H,2-5,9-10,12-13,16-17H2,1H3,(H,29,30) LSSOSVLZUWZYBX-UHFFFAOYSA-N 353081 N,N-bis(cyclopropylmethyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 313 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 420 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353081&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419629 386046820 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696450 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(c2)S(C)(=O)=O)ccc1F InChI=1S/C27H29FN4O2S/c1-32-12-9-19(10-13-32)26-16-24-22(8-11-29-27(24)31-26)23-15-20(6-7-25(23)28)30-17-18-4-3-5-21(14-18)35(2,33)34/h3-8,11,14-16,19,30H,9-10,12-13,17H2,1-2H3,(H,29,31) VAGNIHUQYZRRDW-UHFFFAOYSA-N 353082 4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-[3-(methylsulfonyl)benzyl]aniline::US9796708, Example 314 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353082&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420140 386046821 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696451 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CC1 InChI=1S/C22H22FN3O3S/c1-29-21-5-2-15(23)12-18(21)17-6-9-24-22-19(17)13-20(25-22)14-7-10-26(11-8-14)30(27,28)16-3-4-16/h2,5-7,9,12-13,16H,3-4,8,10-11H2,1H3,(H,24,25) VUYPLDKWOCCCJQ-UHFFFAOYSA-N 353083 2-[1-(cyclopropylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 315 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353083&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419742 386046822 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696452 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)S(N)(=O)=O)ccc1F InChI=1S/C26H28FN5O2S/c1-32-12-9-18(10-13-32)25-15-23-21(8-11-29-26(23)31-25)22-14-19(4-7-24(22)27)30-16-17-2-5-20(6-3-17)35(28,33)34/h2-8,11,14-15,18,30H,9-10,12-13,16H2,1H3,(H,29,31)(H2,28,33,34) WRMMFMUOYQCPRP-UHFFFAOYSA-N 353084 4-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzenesulfonamide::US9796708, Example 316 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353084&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420112 386046823 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696453 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(O)c2)ccc1F InChI=1S/C26H27FN4O/c1-31-11-8-18(9-12-31)25-15-23-21(7-10-28-26(23)30-25)22-14-19(5-6-24(22)27)29-16-17-3-2-4-20(32)13-17/h2-7,10,13-15,18,29,32H,8-9,11-12,16H2,1H3,(H,28,30) ABDYWIXQFSWUQM-UHFFFAOYSA-N 353085 3-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]phenol::US9796708, Example 317 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353085&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420255 386046824 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696454 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(Cl)c2)ccc1F InChI=1S/C26H26ClFN4/c1-32-11-8-18(9-12-32)25-15-23-21(7-10-29-26(23)31-25)22-14-20(5-6-24(22)28)30-16-17-3-2-4-19(27)13-17/h2-7,10,13-15,18,30H,8-9,11-12,16H2,1H3,(H,29,31) XAQBJOSVVUKVLQ-UHFFFAOYSA-N 353086 N-(3-chlorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 318 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420154 386046825 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696455 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(F)cc2)ccc1F InChI=1S/C26H26F2N4/c1-32-12-9-18(10-13-32)25-15-23-21(8-11-29-26(23)31-25)22-14-20(6-7-24(22)28)30-16-17-2-4-19(27)5-3-17/h2-8,11,14-15,18,30H,9-10,12-13,16H2,1H3,(H,29,31) UZYBIRNQTAJXIU-UHFFFAOYSA-N 353087 4-fluoro-N-(4-fluorobenzyl)-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 319 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353087&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420236 386046826 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696456 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccccc2F)ccc1F InChI=1S/C26H26F2N4/c1-32-12-9-17(10-13-32)25-15-22-20(8-11-29-26(22)31-25)21-14-19(6-7-24(21)28)30-16-18-4-2-3-5-23(18)27/h2-8,11,14-15,17,30H,9-10,12-13,16H2,1H3,(H,29,31) SAFIOBLUDLLJKO-UHFFFAOYSA-N 353088 4-fluoro-N-(2-fluorobenzyl)-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 320 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353088&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420734 386046827 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696457 COc1cccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCN(C)CC2)c1 InChI=1S/C27H29FN4O/c1-32-12-9-19(10-13-32)26-16-24-22(8-11-29-27(24)31-26)23-15-20(6-7-25(23)28)30-17-18-4-3-5-21(14-18)33-2/h3-8,11,14-16,19,30H,9-10,12-13,17H2,1-2H3,(H,29,31) IVBOPJGOUXWEIF-UHFFFAOYSA-N 353089 4-fluoro-N-(3-methoxybenzyl)-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353089&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420764 386046828 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696458 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(OCC(O)=O)cc2)ccc1F InChI=1S/C28H29FN4O3/c1-33-12-9-19(10-13-33)26-15-24-22(8-11-30-28(24)32-26)23-14-20(4-7-25(23)29)31-16-18-2-5-21(6-3-18)36-17-27(34)35/h2-8,11,14-15,19,31H,9-10,12-13,16-17H2,1H3,(H,30,32)(H,34,35) UCWMSAAACANERI-UHFFFAOYSA-N 353090 US9796708, Example 322::{4-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]phenoxy}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353090&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897406 386046829 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696459 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCC2CCS(=O)(=O)CC2)ccc1F InChI=1S/C25H31FN4O2S/c1-30-10-5-18(6-11-30)24-15-22-20(4-9-27-25(22)29-24)21-14-19(2-3-23(21)26)28-16-17-7-12-33(31,32)13-8-17/h2-4,9,14-15,17-18,28H,5-8,10-13,16H2,1H3,(H,27,29) PFHDTBGFMOERJN-UHFFFAOYSA-N 353091 N-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl]-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 323 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353091&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897347 386046830 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696460 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CCS(=O)(=O)CC1 InChI=1S/C19H19FN2O4S/c1-26-16-3-2-12(20)10-14(16)13-4-7-21-18-15(13)11-17(22-18)19(23)5-8-27(24,25)9-6-19/h2-4,7,10-11,23H,5-6,8-9H2,1H3,(H,21,22) OEFXUFLJPANOSK-UHFFFAOYSA-N 353092 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]tetrahydro-2H-thiopyran-4-ol 1,1-dioxide::US9796708, Example 324 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 390 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353092&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420106 386046831 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696461 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCS(=O)(=O)CC1 InChI=1S/C19H17FN2O3S/c1-25-18-3-2-13(20)10-15(18)14-4-7-21-19-16(14)11-17(22-19)12-5-8-26(23,24)9-6-12/h2-5,7,10-11H,6,8-9H2,1H3,(H,21,22) IUYOYZMDPKJHIE-UHFFFAOYSA-N 353093 2-(1,1-dioxido-3,6-dihydro-2H-thiopyran-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 325 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353093&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897376 386046832 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696462 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CCNC1 353094 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]pyrrolidin-3-ol::US9796708, Example 326 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353094&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420697 386046833 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697256 CCOC(=O)NS(=O)(=O)N1CCC(CC1)c1cc2c(c(F)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H24F2N4O5S/c1-3-33-22(29)27-34(30,31)28-8-6-13(7-9-28)18-11-16-20(17(24)12-25-21(16)26-18)15-10-14(23)4-5-19(15)32-2/h4-5,10-13H,3,6-9H2,1-2H3,(H,25,26)(H,27,29) KWCZHTWEKIGEMB-UHFFFAOYSA-N 353888 US9796708, Example 1120::ethyl ({4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}sulfonyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353888&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208161 386047621 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697257 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(=O)N(C)CCO)CC1 InChI=1S/C24H28F2N4O3/c1-29(9-10-31)22(32)14-30-7-5-15(6-8-30)20-12-18-23(19(26)13-27-24(18)28-20)17-11-16(25)3-4-21(17)33-2/h3-4,11-13,15,31H,5-10,14H2,1-2H3,(H,27,28) ABRXHAYBAQGSII-UHFFFAOYSA-N 353889 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1121 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353889&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420562 386047622 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697258 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N(C([O-])=O)S(=O)(=O)N1CC(O)C1 353890 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl[(3-hydroxyazetidin-1-yl)sulfonyl]carbamate::US9796708, Example 1122 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353890&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208162 386047623 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697259 COCCS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H24FN3O4S/c1-29-11-12-31(27,28)26-9-6-15(7-10-26)20-14-19-17(5-8-24-22(19)25-20)18-13-16(23)3-4-21(18)30-2/h3-6,8,13-14H,7,9-12H2,1-2H3,(H,24,25) SVQVZUJNGOTASC-UHFFFAOYSA-N 353891 4-(5-fluoro-2-methoxyphenyl)-2-{1-[(2-methoxyethyl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353891&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897380 386047624 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697260 COCCOCCS(=O)(=O)NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353892 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-2-(2-methoxyethoxy)ethanesulfonamide::US9796708, Example 1124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353892&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420095 386047625 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697261 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC(C1)C(=O)OC(C)(C)C InChI=1S/C28H32FN3O3/c1-28(2,3)35-27(33)18-13-20(14-18)32-11-8-17(9-12-32)24-16-23-21(7-10-30-26(23)31-24)22-15-19(29)5-6-25(22)34-4/h5-8,10,15-16,18,20H,9,11-14H2,1-4H3,(H,30,31) NVKPNYVEDLGVGZ-UHFFFAOYSA-N 353893 US9796708, Example 1125::tert-butyl 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobutanecarboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353893&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897353 386047626 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697262 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC(C1)C(O)=O InChI=1S/C24H24FN3O3/c1-31-22-3-2-16(25)12-19(22)18-4-7-26-23-20(18)13-21(27-23)14-5-8-28(9-6-14)17-10-15(11-17)24(29)30/h2-5,7,12-13,15,17H,6,8-11H2,1H3,(H,26,27)(H,29,30) JJXGECIPCDHZFQ-UHFFFAOYSA-N 353894 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclobutanecarboxylic acid::US9796708, Example 1126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353894&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419841 386047627 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697263 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC2C1)S(C)(=O)=O 353895 4-(5-fluoro-2-methoxyphenyl)-2-[2-(methylsulfonyl)octahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353895&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420928 386047628 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697264 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](CO)N(CC(O)=O)C1 InChI=1S/C21H20FN3O4/c1-29-19-3-2-13(22)7-16(19)15-4-5-23-21-17(15)8-18(24-21)12-6-14(11-26)25(9-12)10-20(27)28/h2-8,14,26H,9-11H2,1H3,(H,23,24)(H,27,28)/t14-/m0/s1 PVQHSMNRPRSITM-AWEZNQCLSA-N 353896 US9796708, Example 1128::[(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-2,5-dihydro-1H-pyrrol-1-yl]acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353896&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420223 386047629 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697265 CNC(=O)[C@H](NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)C(C)C InChI=1S/C26H31FN4O2/c1-15(2)24(26(32)28-3)30-18-8-5-16(6-9-18)22-14-21-19(11-12-29-25(21)31-22)20-13-17(27)7-10-23(20)33-4/h5,7,10-15,18,24,30H,6,8-9H2,1-4H3,(H,28,32)(H,29,31)/t18?,24-/m1/s1 WXQMINQGBDNNHY-VCUSLETLSA-N 353897 N2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-N-methyl-D-valinamide::US9796708, Example 1129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353897&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421007 386047630 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697266 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](Cc1ccccc1)C(O)=O InChI=1S/C29H28FN3O3/c1-36-27-12-9-20(30)16-23(27)22-13-14-31-28-24(22)17-25(33-28)19-7-10-21(11-8-19)32-26(29(34)35)15-18-5-3-2-4-6-18/h2-7,9,12-14,16-17,21,26,32H,8,10-11,15H2,1H3,(H,31,33)(H,34,35)/t21?,26-/m0/s1 NXVGVUIETPUULW-UQTORGHUSA-N 353898 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-phenylalanine::US9796708, Example 1130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353898&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897282 386047631 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697267 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](Cc1ccc(O)cc1)C(O)=O InChI=1S/C29H28FN3O4/c1-37-27-11-6-19(30)15-23(27)22-12-13-31-28-24(22)16-25(33-28)18-4-7-20(8-5-18)32-26(29(35)36)14-17-2-9-21(34)10-3-17/h2-4,6,9-13,15-16,20,26,32,34H,5,7-8,14H2,1H3,(H,31,33)(H,35,36)/t20?,26-/m0/s1 QDJQMDNYCHUJED-GHZUAHJPSA-N 353899 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-tyrosine::US9796708, Example 1131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353899&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420773 386047632 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697268 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](C(C)C)C(N)=O InChI=1S/C25H29FN4O2/c1-14(2)23(24(27)31)29-17-7-4-15(5-8-17)21-13-20-18(10-11-28-25(20)30-21)19-12-16(26)6-9-22(19)32-3/h4,6,9-14,17,23,29H,5,7-8H2,1-3H3,(H2,27,31)(H,28,30)/t17?,23-/m0/s1 GPYFKOIVCYLTNF-VXLWULRPSA-N 353900 N2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-valinamide::US9796708, Example 1132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353900&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897220 386047633 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697269 CNC(=O)[C@@H](NC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC)C(C)(C)C InChI=1S/C27H33FN4O2/c1-27(2,3)24(26(33)29-4)31-18-9-6-16(7-10-18)22-15-21-19(12-13-30-25(21)32-22)20-14-17(28)8-11-23(20)34-5/h6,8,11-15,18,24,31H,7,9-10H2,1-5H3,(H,29,33)(H,30,32)/t18?,24-/m1/s1 OCUJYVHMXHXYJS-VCUSLETLSA-N 353901 N2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-N,3-dimethyl-L-valinamide::US9796708, Example 1133 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353901&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419623 386047634 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697270 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)[C@@](N)(C(O)=O)c1ccccc1 InChI=1S/C28H26FN3O3/c1-35-25-12-11-20(29)15-22(25)21-13-14-31-26-23(21)16-24(32-26)17-7-9-19(10-8-17)28(30,27(33)34)18-5-3-2-4-6-18/h2-7,11-16,19H,8-10,30H2,1H3,(H,31,32)(H,33,34)/t19?,28-/m1/s1 MWNLDXNRMLJUQD-FYJJZCTHSA-N 353902 (2S)-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl})amino)(phenyl)acetic acid::US9796708, Example 1134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353902&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208163 386047635 C02623 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697271 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC#N)C#N InChI=1S/C23H18FN5O2/c1-31-20-3-2-16(24)10-17(20)22-15(12-26)13-27-23-18(22)11-19(28-23)14-5-8-29(9-6-14)21(30)4-7-25/h2-3,5,10-11,13H,4,6,8-9H2,1H3,(H,27,28) BTMZBTGHMFVXST-UHFFFAOYSA-N 353903 2-[1-(cyanoacetyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353903&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421322 386047636 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697272 COc1ccc(F)cc1-c1ccnc2[nH]c(c([N+]([O-])=O)c12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H19FN4O5S/c1-30-16-4-3-13(21)11-15(16)14-5-8-22-20-17(14)19(25(26)27)18(23-20)12-6-9-24(10-7-12)31(2,28)29/h3-6,8,11H,7,9-10H2,1-2H3,(H,22,23) JOUUBVZESFTMJY-UHFFFAOYSA-N 353904 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-3-nitro-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353904&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420204 386047637 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697273 COCCOCCS(=O)(=O)N1CC2CC(=CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353905 4-(5-fluoro-2-methoxyphenyl)-2-(2-{[2-(2-methoxyethoxy)ethyl]sulfonyl}-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1137 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353905&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419562 386047638 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697274 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H]2COC(=O)CN2CC1 InChI=1S/C22H20FN3O3/c1-28-20-3-2-14(23)9-17(20)16-4-6-24-22-18(16)10-19(25-22)13-5-7-26-11-21(27)29-12-15(26)8-13/h2-4,6,8-10,15H,5,7,11-12H2,1H3,(H,24,25)/t15-/m1/s1 RILPISOLMJUBNV-OAHLLOKOSA-N 353906 (9aR)-8-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,6,7,9a-tetrahydropyrido[2,1-c][1,4]oxazin-3(4H)-one::US9796708, Example 1138 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353906&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420955 386047639 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697275 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2COC(=O)N2CC1 353907 7-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,5,6,8a-tetrahydro[1,3]oxazolo[3,4-a]pyridin-3-one::US9796708, Example 1139 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353907&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419885 386047640 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697276 COCCN(C)C(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H31FN4O3/c1-29(12-13-32-2)24(31)16-30-10-7-17(8-11-30)22-15-21-19(6-9-27-25(21)28-22)20-14-18(26)4-5-23(20)33-3/h4-6,9,14-15,17H,7-8,10-13,16H2,1-3H3,(H,27,28) KLZRSAOQUAPQBP-UHFFFAOYSA-N 353908 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-(2-methoxyethyl)-N-methylacetamide::US9796708, Example 1140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353908&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420076 386047641 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697277 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(C(O)=O)c1ccccc1 353909 US9796708, Example 1141::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}(phenyl)acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353909&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419906 386047642 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697278 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(N)=O)CC1)C#N InChI=1S/C22H20FN5O2/c1-30-19-3-2-15(23)8-16(19)21-14(10-24)11-26-22-17(21)9-18(27-22)13-4-6-28(7-5-13)12-20(25)29/h2-4,8-9,11H,5-7,12H2,1H3,(H2,25,29)(H,26,27) UNJBMXAWJWVJSD-UHFFFAOYSA-N 353910 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetamide::US9796708, Example 1142 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353910&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897321 386047643 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697279 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(NC1)C(=O)NC1CC(F)C1 353911 N-(3-fluorocyclobutyl)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydro-1H-pyrrole-2-carboxamide::US9796708, Example 1143 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353911&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419713 386047644 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697280 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](C)NCC1 InChI=1S/C20H20FN3O/c1-12-9-13(5-7-22-12)18-11-17-15(6-8-23-20(17)24-18)16-10-14(21)3-4-19(16)25-2/h3-4,6,8-12,22H,5,7H2,1-2H3,(H,23,24)/t12-/m1/s1 WSCONERQESPBQY-GFCCVEGCSA-N 353793 4-(5-fluoro-2-methoxyphenyl)-2-[(6R)-6-methyl-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1025::US9796708, Example 1144 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353793&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420421 386047526 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697281 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(C)(C)N(CC(=O)N(C)C)CC1 InChI=1S/C25H29FN4O2/c1-25(2)14-16(9-11-30(25)15-23(31)29(3)4)21-13-20-18(8-10-27-24(20)28-21)19-12-17(26)6-7-22(19)32-5/h6-8,10,12-14H,9,11,15H2,1-5H3,(H,27,28) RRFIAZLNXZLWQP-UHFFFAOYSA-N 353913 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6,6-dimethyl-3,6-dihydropyridin-1(2H)-yl}-N,N-dimethylacetamide::US9796708, Example 1145 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353913&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419656 386047645 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697282 CNC(=O)N1CC(=CC1C(=O)OC)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353914 US9796708, Example 1146::methyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(methylcarbamoyl)-2,5-dihydro-1H-pyrrole-2-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353914&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420478 386047646 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697283 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CNCC2C1)C#N 353915 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1147 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353915&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413934 386047647 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697284 CNC(=O)N1CC2CC(=CC2C1)c1cc2c(c(cnc2[nH]1)C#N)-c1cc(F)ccc1OC 353916 5-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9796708, Example 1148 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353916&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419805 386047648 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697285 NC(=O)CN1CC2CC(=CC2C1)c1cc2c(c(cnc2[nH]1)C#N)-c1cc(F)ccc1O 353917 2-{5-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}acetamide::US9796708, Example 1149 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353917&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208164 386047649 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697286 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NC#N)CC1 InChI=1S/C22H20FN5O2/c1-30-20-3-2-15(23)10-17(20)16-4-7-25-22-18(16)11-19(27-22)14-5-8-28(9-6-14)12-21(29)26-13-24/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,25,27)(H,26,29) OTIVWVPLVUEWAO-UHFFFAOYSA-N 353918 N-cyano-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetamide::US9796708, Example 1150 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 590 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353918&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897331 386047650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697287 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(C)=O 353919 1-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}ethanone::US9796708, Example 1151 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353919&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419895 386047651 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697288 CCOC(=O)C1CCCN(C1)S(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353920 US9796708, Example 1152::ethyl 1-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)piperidine-3-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 380 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353920&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419548 386047652 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697289 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(N)=O)CC2C1 353921 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}acetamide::US9796708, Example 1153 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353921&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420207 386047653 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697290 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)NC#N 353922 N-cyano-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9796708, Example 1154 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353922&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420560 386047654 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697291 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C(=O)NC#N InChI=1S/C21H20FN5O2/c1-29-19-3-2-14(22)10-16(19)15-4-7-24-20-17(15)11-18(26-20)13-5-8-27(9-6-13)21(28)25-12-23/h2-4,7,10-11,13H,5-6,8-9H2,1H3,(H,24,26)(H,25,28) KNIJJYNRPHJWJQ-UHFFFAOYSA-N 353923 N-cyano-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidine-1-carboxamide::US9796708, Example 1155 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353923&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420557 386047655 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697292 CNS(=O)(=O)CC(=O)N1CCC(CC1)c1cc2c(c(cnc2[nH]1)C#N)-c1cc(F)ccc1OC InChI=1S/C23H24FN5O4S/c1-26-34(31,32)13-21(30)29-7-5-14(6-8-29)19-10-18-22(15(11-25)12-27-23(18)28-19)17-9-16(24)3-4-20(17)33-2/h3-4,9-10,12,14,26H,5-8,13H2,1-2H3,(H,27,28) YXYNIZQKCPXFBO-UHFFFAOYSA-N 353924 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methyl-2-oxoethanesulfonamide::US9796708, Example 1156 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353924&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420156 386047656 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697293 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CC(CC2C1)N[C@H](C(C)C)C(O)=O InChI=1S/C27H30FN3O3/c1-14(2)25(27(32)33)30-19-10-15-8-17(9-16(15)11-19)23-13-22-20(6-7-29-26(22)31-23)21-12-18(28)4-5-24(21)34-3/h4-8,12-16,19,25,30H,9-11H2,1-3H3,(H,29,31)(H,32,33)/t15?,16?,19?,25-/m1/s1 ZERSWHJDFKNITA-LZKQKUKTSA-N 353925 N-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,3a,4,6a-hexahydropentalen-2-yl}-D-valine::US9796708, Example 1157 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353925&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420287 386047657 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697294 COC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H20FN3O3/c1-27-19-4-3-14(22)11-16(19)15-5-8-23-20-17(15)12-18(24-20)13-6-9-25(10-7-13)21(26)28-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,23,24) QBSIMYIEZLKPRJ-UHFFFAOYSA-N 353926 US9796708, Example 1158::methyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420107 386047658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697295 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CNCC2C1 353927 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1159 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353927&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413493 386047659 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697296 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)CCO)CC1)C#N InChI=1S/C25H26FN5O3/c1-30(9-10-32)23(33)15-31-7-5-16(6-8-31)21-12-20-24(17(13-27)14-28-25(20)29-21)19-11-18(26)3-4-22(19)34-2/h3-5,11-12,14,32H,6-10,15H2,1-2H3,(H,28,29) OITCRYNPBRVUSS-UHFFFAOYSA-N 353928 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1160 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353928&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419977 386047660 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697297 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)OCC(=O)N(C)C 353929 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}oxy)-N,N-dimethylacetamide::US9796708, Example 1161 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353929&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420250 386047661 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697298 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)OCC(=O)N1CCOCC1 353930 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}oxy)-1-(morpholin-4-yl)ethanone::US9796708, Example 1162 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353930&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897307 386047662 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697299 CSc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O2S2/c1-27-19-4-3-14(21)11-16(19)15-5-8-22-20-17(15)12-18(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) QLMNNUFFIGMZRB-UHFFFAOYSA-N 353931 4-[5-fluoro-2-(methylsulfanyl)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1163 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420471 386047663 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697300 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(O)C2)CC1)C#N InChI=1S/C25H24FN5O3/c1-34-22-3-2-17(26)8-19(22)24-16(10-27)11-28-25-20(24)9-21(29-25)15-4-6-30(7-5-15)14-23(33)31-12-18(32)13-31/h2-4,8-9,11,18,32H,5-7,12-14H2,1H3,(H,28,29) LAMFTUIDHNOTAR-UHFFFAOYSA-N 353932 4-(5-fluoro-2-methoxyphenyl)-2-{1-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1164 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353932&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897371 386047664 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697301 CNS(=O)(=O)CC(=O)N1CCC(=CC1)c1cc2c(c(cnc2[nH]1)C#N)-c1cc(F)ccc1OC InChI=1S/C23H22FN5O4S/c1-26-34(31,32)13-21(30)29-7-5-14(6-8-29)19-10-18-22(15(11-25)12-27-23(18)28-19)17-9-16(24)3-4-20(17)33-2/h3-5,9-10,12,26H,6-8,13H2,1-2H3,(H,27,28) SJXRZCNQEOLYSP-UHFFFAOYSA-N 353933 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1 (2H)-yl}-N-methyl-2-oxoethanesulfonamide::US9796708, Example 1165 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421486 386047665 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697302 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC(N)=O)CC1)C#N InChI=1S/C22H22FN5O2/c1-30-19-3-2-15(23)8-16(19)21-14(10-24)11-26-22-17(21)9-18(27-22)13-4-6-28(7-5-13)12-20(25)29/h2-3,8-9,11,13H,4-7,12H2,1H3,(H2,25,29)(H,26,27) BFCXPFRZELVPIU-UHFFFAOYSA-N 353934 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetamide::US9796708, Example 1166 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897199 386047666 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697303 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C2CC(O)C2)CC1 InChI=1S/C26H29FN4O3/c1-30(18-12-19(32)13-18)25(33)15-31-9-6-16(7-10-31)23-14-22-20(5-8-28-26(22)29-23)21-11-17(27)3-4-24(21)34-2/h3-6,8,11,14,18-19,32H,7,9-10,12-13,15H2,1-2H3,(H,28,29) RSEKHIBDOWHPPM-UHFFFAOYSA-N 353935 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1167 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353935&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897485 386047667 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697304 COCCN(C)C(=O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C25H29FN4O3/c1-29(12-13-32-2)24(31)16-30-10-7-17(8-11-30)22-15-21-19(6-9-27-25(21)28-22)20-14-18(26)4-5-23(20)33-3/h4-7,9,14-15H,8,10-13,16H2,1-3H3,(H,27,28) TYJHRLYAMZCZHJ-UHFFFAOYSA-N 353936 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(2-methoxyethyl)-N-methylacetamide::US9796708, Example 1168 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353936&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419616 386047668 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697305 COC(=O)C[C@H]1CC[C@H](CC1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353937 US9796708, Example 1169::methyl (cis-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414211 386047669 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697306 COC(=O)C[C@H]1CC[C@@H](CC1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353938 US9796708, Example 1170::methyl (trans-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90414211 386047670 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697307 COC(=O)CC1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353939 US9796708, Example 1171::methyl {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 990 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353939&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208165 386047671 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696463 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNC1 InChI=1S/C18H16FN3O/c1-23-17-3-2-12(19)8-14(17)13-5-7-21-18-15(13)9-16(22-18)11-4-6-20-10-11/h2-5,7-9,20H,6,10H2,1H3,(H,21,22) PDQGGOPDRYPKSB-UHFFFAOYSA-N 353095 2-(2,5-dihydro-1H-pyrrol-3-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 327 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353095&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419908 386046834 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696464 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(F)c2)ccc1F InChI=1S/C26H26F2N4/c1-32-11-8-18(9-12-32)25-15-23-21(7-10-29-26(23)31-25)22-14-20(5-6-24(22)28)30-16-17-3-2-4-19(27)13-17/h2-7,10,13-15,18,30H,8-9,11-12,16H2,1H3,(H,29,31) YSNYPHZKOZJISP-UHFFFAOYSA-N 353096 4-fluoro-N-(3-fluorobenzyl)-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 328 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353096&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421745 386046835 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696465 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(F)cc2F)ccc1F InChI=1S/C26H25F3N4/c1-33-10-7-16(8-11-33)25-14-22-20(6-9-30-26(22)32-25)21-13-19(4-5-23(21)28)31-15-17-2-3-18(27)12-24(17)29/h2-6,9,12-14,16,31H,7-8,10-11,15H2,1H3,(H,30,32) CTIBBRNTGBIXLW-UHFFFAOYSA-N 353097 N-(2,4-difluorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 329 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353097&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897440 386046836 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696466 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2c(F)cccc2F)ccc1F InChI=1S/C26H25F3N4/c1-33-11-8-16(9-12-33)25-14-20-18(7-10-30-26(20)32-25)19-13-17(5-6-24(19)29)31-15-21-22(27)3-2-4-23(21)28/h2-7,10,13-14,16,31H,8-9,11-12,15H2,1H3,(H,30,32) CIWVOIZKILFWGU-UHFFFAOYSA-N 353098 N-(2,6-difluorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 330 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353098&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897413 386046837 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696467 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CCl InChI=1S/C20H19ClFN3O3S/c1-28-19-3-2-14(22)10-16(19)15-4-7-23-20-17(15)11-18(24-20)13-5-8-25(9-6-13)29(26,27)12-21/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,23,24) WIYRDGDFZRRGJV-UHFFFAOYSA-N 353099 2-{1-[(chloromethyl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 331 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353099&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897295 386046838 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696468 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C(C)C InChI=1S/C22H24FN3O3S/c1-14(2)30(27,28)26-10-7-15(8-11-26)20-13-19-17(6-9-24-22(19)25-20)18-12-16(23)4-5-21(18)29-3/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,24,25) WRWRSYDSFJLDAM-UHFFFAOYSA-N 353100 4-(5-fluoro-2-methoxyphenyl)-2-[1-(propan-2-ylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 332 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353100&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420440 386046839 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696469 CCCS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H24FN3O3S/c1-3-12-30(27,28)26-10-7-15(8-11-26)20-14-19-17(6-9-24-22(19)25-20)18-13-16(23)4-5-21(18)29-2/h4-7,9,13-14H,3,8,10-12H2,1-2H3,(H,24,25) LZRZDMUMYWGSIR-UHFFFAOYSA-N 353101 4-(5-fluoro-2-methoxyphenyl)-2-[1-(propylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 333 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353101&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420748 386046840 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696470 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)C1CCS(=O)(=O)C1 353102 2-{1-[(1,1-dioxidotetrahydrothiophen-3-yl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 334 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 46.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353102&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897395 386046841 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696471 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)ccc2F)ccc1F InChI=1S/C26H25F3N4/c1-33-10-7-16(8-11-33)25-14-22-20(6-9-30-26(22)32-25)21-13-19(3-5-24(21)29)31-15-17-12-18(27)2-4-23(17)28/h2-6,9,12-14,16,31H,7-8,10-11,15H2,1H3,(H,30,32) ROYJQOBADSPLFB-UHFFFAOYSA-N 353103 N-(2,5-difluorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 335 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353103&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897253 386046842 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696472 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CC(F)(F)F InChI=1S/C21H19F4N3O3S/c1-31-19-3-2-14(22)10-16(19)15-4-7-26-20-17(15)11-18(27-20)13-5-8-28(9-6-13)32(29,30)12-21(23,24)25/h2-5,7,10-11H,6,8-9,12H2,1H3,(H,26,27) MAYWSTWBYIFZEA-UHFFFAOYSA-N 353104 4-(5-fluoro-2-methoxyphenyl)-2-{1-[(2,2,2-trifluoroethyl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 336 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353104&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897381 386046843 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696473 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccccc2Cl)ccc1F InChI=1S/C26H26ClFN4/c1-32-12-9-17(10-13-32)25-15-22-20(8-11-29-26(22)31-25)21-14-19(6-7-24(21)28)30-16-18-4-2-3-5-23(18)27/h2-8,11,14-15,17,30H,9-10,12-13,16H2,1H3,(H,29,31) KMQDUXDHENZSRJ-UHFFFAOYSA-N 353105 N-(2-chlorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 337 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353105&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420849 386046844 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696474 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(c2)C(O)=O)ccc1F InChI=1S/C27H27FN4O2/c1-32-11-8-18(9-12-32)25-15-23-21(7-10-29-26(23)31-25)22-14-20(5-6-24(22)28)30-16-17-3-2-4-19(13-17)27(33)34/h2-7,10,13-15,18,30H,8-9,11-12,16H2,1H3,(H,29,31)(H,33,34) RQUXGRRMDHCICE-UHFFFAOYSA-N 353106 3-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzoic acid::US9796708, Example 338 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 380 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353106&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419661 386046845 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696475 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)C#N)ccc1F InChI=1S/C27H26FN5/c1-33-12-9-20(10-13-33)26-15-24-22(8-11-30-27(24)32-26)23-14-21(6-7-25(23)28)31-17-19-4-2-18(16-29)3-5-19/h2-8,11,14-15,20,31H,9-10,12-13,17H2,1H3,(H,30,32) OYLVPRAOMPFNAP-UHFFFAOYSA-N 353107 4-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzonitrile::US9796708, Example 339 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353107&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421274 386046846 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696476 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccccc2C#N)ccc1F InChI=1S/C27H26FN5/c1-33-12-9-18(10-13-33)26-15-24-22(8-11-30-27(24)32-26)23-14-21(6-7-25(23)28)31-17-20-5-3-2-4-19(20)16-29/h2-8,11,14-15,18,31H,9-10,12-13,17H2,1H3,(H,30,32) LGHVRFUQYMQMKH-UHFFFAOYSA-N 353108 2-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzonitrile::US9796708, Example 340 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353108&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420619 386046847 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696477 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(c2)C#N)ccc1F InChI=1S/C27H26FN5/c1-33-11-8-20(9-12-33)26-15-24-22(7-10-30-27(24)32-26)23-14-21(5-6-25(23)28)31-17-19-4-2-3-18(13-19)16-29/h2-7,10,13-15,20,31H,8-9,11-12,17H2,1H3,(H,30,32) DMUFREFEFTYQRQ-UHFFFAOYSA-N 353109 3-[({4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzonitrile::US9796708, Example 341 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353109&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420796 386046848 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696478 COCn1cc(CN[C@H]2CC[C@@H](CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)nn1 353110 US9796708, Example 342::trans-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{[1-(methoxymethyl)-1H-1,2,3-triazol-4-yl]methyl}cyclohexanamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353110&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420220 386046849 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696479 COCn1nncc1CN[C@H]1CC[C@@H](CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353111 US9796708, Example 343::trans-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-{[1-(methoxymethyl)-1H-1,2,3-triazol-5-yl]methyl}cyclohexanamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353111&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897469 386046850 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696480 CC1(CNc2cc(c(F)cc2F)-c2ccnc3[nH]c(cc23)C2CCNCC2)CCOCC1 InChI=1S/C25H30F2N4O/c1-25(5-10-32-11-6-25)15-30-23-12-18(20(26)14-21(23)27)17-4-9-29-24-19(17)13-22(31-24)16-2-7-28-8-3-16/h4,9,12-14,16,28,30H,2-3,5-8,10-11,15H2,1H3,(H,29,31) LYXGMLBMSIISDR-UHFFFAOYSA-N 353112 2,4-difluoro-N-[(4-methyltetrahydro-2H-pyran-4-yl)methyl]-5-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 344 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353112&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419833 386046851 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696481 Fc1cc(F)c(cc1NCc1ccccc1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H24F2N4/c26-21-14-22(27)24(30-15-16-4-2-1-3-5-16)12-19(21)18-8-11-29-25-20(18)13-23(31-25)17-6-9-28-10-7-17/h1-5,8,11-14,17,28,30H,6-7,9-10,15H2,(H,29,31) CWBNKHNBBDYRLV-UHFFFAOYSA-N 353113 N-benzyl-2,4-difluoro-5-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 345 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353113&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420175 386046852 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696482 Fc1cc(F)c(cc1NCC1CCOCC1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H28F2N4O/c25-20-13-21(26)23(29-14-15-4-9-31-10-5-15)11-18(20)17-3-8-28-24-19(17)12-22(30-24)16-1-6-27-7-2-16/h3,8,11-13,15-16,27,29H,1-2,4-7,9-10,14H2,(H,28,30) ZKCICXZUQUYYMH-UHFFFAOYSA-N 353114 2,4-difluoro-5-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(tetrahydro-2H-pyran-4-ylmethyl)aniline::US9796708, Example 346 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353114&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420368 386046853 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696483 Fc1cccc(CNc2cc(c(F)cc2F)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C25H23F3N4/c26-17-3-1-2-15(10-17)14-31-24-11-19(21(27)13-22(24)28)18-6-9-30-25-20(18)12-23(32-25)16-4-7-29-8-5-16/h1-3,6,9-13,16,29,31H,4-5,7-8,14H2,(H,30,32) GIYOAWSOVWBBGQ-UHFFFAOYSA-N 353115 2,4-difluoro-N-(3-fluorobenzyl)-5-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 347 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353115&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420357 386046854 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696484 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)c1cccs1 InChI=1S/C23H20FN3O3S2/c1-30-21-5-4-16(24)13-18(21)17-6-9-25-23-19(17)14-20(26-23)15-7-10-27(11-8-15)32(28,29)22-3-2-12-31-22/h2-7,9,12-14H,8,10-11H2,1H3,(H,25,26) HZFVOEDIGRMCEM-UHFFFAOYSA-N 353116 4-(5-fluoro-2-methoxyphenyl)-2-[1-(thiophen-2-ylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 348 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3400 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353116&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421585 386046855 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696485 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)c1ccc(NC(C)=O)c(Cl)c1 InChI=1S/C27H24ClFN4O4S/c1-16(34)31-24-5-4-19(14-23(24)28)38(35,36)33-11-8-17(9-12-33)25-15-22-20(7-10-30-27(22)32-25)21-13-18(29)3-6-26(21)37-2/h3-8,10,13-15H,9,11-12H2,1-2H3,(H,30,32)(H,31,34) QLLTXYYJTFCYBX-UHFFFAOYSA-N 353117 N-[2-chloro-4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)phenyl]acetamide::US9796708, Example 349 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 510 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353117&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421099 386046856 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696486 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl InChI=1S/C25H19Cl3FN3O3S/c1-35-23-3-2-15(29)10-17(23)16-4-7-30-25-18(16)11-22(31-25)14-5-8-32(9-6-14)36(33,34)24-13-20(27)19(26)12-21(24)28/h2-5,7,10-13H,6,8-9H2,1H3,(H,30,31) UOBUFXIWPSRFPR-UHFFFAOYSA-N 353118 4-(5-fluoro-2-methoxyphenyl)-2-{1-[(2,4,5-trichlorophenyl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 350 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353118&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420769 386046857 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696487 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)c1cccc2nonc12 InChI=1S/C25H20FN5O4S/c1-34-22-6-5-16(26)13-18(22)17-7-10-27-25-19(17)14-21(28-25)15-8-11-31(12-9-15)36(32,33)23-4-2-3-20-24(23)30-35-29-20/h2-8,10,13-14H,9,11-12H2,1H3,(H,27,28) ZDCMTRCYOCRRSH-UHFFFAOYSA-N 353119 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)-2,1,3-benzoxadiazole::US9796708, Example 351 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353119&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420376 386046858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696488 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)c1c(C)noc1C InChI=1S/C24H23FN4O4S/c1-14-23(15(2)33-28-14)34(30,31)29-10-7-16(8-11-29)21-13-20-18(6-9-26-24(20)27-21)19-12-17(25)4-5-22(19)32-3/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,26,27) SEWQWXJOZCIXSG-UHFFFAOYSA-N 353120 2-{1-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 352 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 630 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353120&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897408 386046859 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696489 Fc1ccc(NCc2cccc(Cl)c2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H24ClFN4/c26-18-3-1-2-16(12-18)15-30-19-4-5-23(27)21(13-19)20-8-11-29-25-22(20)14-24(31-25)17-6-9-28-10-7-17/h1-5,8,11-14,17,28,30H,6-7,9-10,15H2,(H,29,31) SZDSWKUUONKCQG-UHFFFAOYSA-N 353121 N-(3-chlorobenzyl)-4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 353 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353121&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420673 386046860 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696490 Fc1cccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C25H24F2N4/c26-18-3-1-2-16(12-18)15-30-19-4-5-23(27)21(13-19)20-8-11-29-25-22(20)14-24(31-25)17-6-9-28-10-7-17/h1-5,8,11-14,17,28,30H,6-7,9-10,15H2,(H,29,31) ZMRUTYGEJAHRJL-UHFFFAOYSA-N 353122 4-fluoro-N-(3-fluorobenzyl)-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 354 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353122&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419913 386046861 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696491 Fc1ccc(NCc2ccc(cc2)C#N)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C26H24FN5/c27-24-6-5-20(31-16-18-3-1-17(15-28)2-4-18)13-22(24)21-9-12-30-26-23(21)14-25(32-26)19-7-10-29-11-8-19/h1-6,9,12-14,19,29,31H,7-8,10-11,16H2,(H,30,32) RYDDLVRXMLUPFS-UHFFFAOYSA-N 353123 4-[({4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzonitrile::US9796708, Example 355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353123&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420391 386046862 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696492 CS(=O)(=O)c1ccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)cc1 InChI=1S/C26H27FN4O2S/c1-34(32,33)20-5-2-17(3-6-20)16-30-19-4-7-24(27)22(14-19)21-10-13-29-26-23(21)15-25(31-26)18-8-11-28-12-9-18/h2-7,10,13-15,18,28,30H,8-9,11-12,16H2,1H3,(H,29,31) LRUBSVFNLJTGJA-UHFFFAOYSA-N 353124 4-fluoro-N-[4-(methylsulfonyl)benzyl]-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 356 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353124&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419990 386046863 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696493 Fc1ccc(NCc2ccncc2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H24FN5/c25-22-2-1-18(29-15-16-3-8-26-9-4-16)13-20(22)19-7-12-28-24-21(19)14-23(30-24)17-5-10-27-11-6-17/h1-4,7-9,12-14,17,27,29H,5-6,10-11,15H2,(H,28,30) PRRNXKOLFUZBBW-UHFFFAOYSA-N 353125 4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(pyridin-4-ylmethyl)aniline::US9796708, Example 357 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353125&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421171 386046864 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696494 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CNC1 InChI=1S/C17H16FN3O2/c1-23-14-3-2-10(18)6-12(14)11-4-5-20-16-13(11)7-15(21-16)17(22)8-19-9-17/h2-7,19,22H,8-9H2,1H3,(H,20,21) WVQBLDJFOLMMTR-UHFFFAOYSA-N 353126 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]azetidin-3-ol::US9796708, Example 358 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353126&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419929 386046865 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696495 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1(O)CCN(CC1)S(C)(=O)=O InChI=1S/C20H22FN3O4S/c1-28-17-4-3-13(21)11-15(17)14-5-8-22-19-16(14)12-18(23-19)20(25)6-9-24(10-7-20)29(2,26)27/h3-5,8,11-12,25H,6-7,9-10H2,1-2H3,(H,22,23) ULIMQBPPJUOIIC-UHFFFAOYSA-N 353127 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(methylsulfonyl)piperidin-4-ol::US9796708, Example 359 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 460 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353127&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420000 386046866 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696496 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccccc2)CC1 InChI=1S/C26H26FN3O/c1-31-25-8-7-20(27)15-22(25)21-9-12-28-26-23(21)16-24(29-26)19-10-13-30(14-11-19)17-18-5-3-2-4-6-18/h2-9,12,15-16,19H,10-11,13-14,17H2,1H3,(H,28,29) DLZLKCRMBZKTEE-UHFFFAOYSA-N 353128 2-(1-benzylpiperidin-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 360 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353128&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420830 386046867 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696497 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(C)CC1 InChI=1S/C20H20FN3O/c1-24-9-6-13(7-10-24)18-12-17-15(5-8-22-20(17)23-18)16-11-14(21)3-4-19(16)25-2/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) RGPWFFJCORGYLI-UHFFFAOYSA-N 353129 4-(5-fluoro-2-methoxyphenyl)-2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 361 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353129&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419802 386046868 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696498 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(N)ccc1F InChI=1S/C19H19FN4O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-16-14(4-7-22-19(16)23-18)15-10-13(21)2-3-17(15)20/h2-5,7,10-11H,6,8-9,21H2,1H3,(H,22,23) FZBHHRNHJNOMLW-UHFFFAOYSA-N 353130 4-fluoro-3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 362 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353130&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897378 386046869 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696499 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccnc2)ccc1F InChI=1S/C25H26FN5/c1-31-11-7-18(8-12-31)24-14-22-20(6-10-28-25(22)30-24)21-13-19(4-5-23(21)26)29-16-17-3-2-9-27-15-17/h2-6,9-10,13-15,18,29H,7-8,11-12,16H2,1H3,(H,28,30) HQFULBNBPBGBJH-UHFFFAOYSA-N 353131 4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(pyridin-3-ylmethyl)aniline::US9796708, Example 363 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353131&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420990 386046870 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696500 Fc1ccc(NCc2cccnc2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H24FN5/c25-22-4-3-18(29-15-16-2-1-8-27-14-16)12-20(22)19-7-11-28-24-21(19)13-23(30-24)17-5-9-26-10-6-17/h1-4,7-8,11-14,17,26,29H,5-6,9-10,15H2,(H,28,30) WDMZVXIOGCTPCB-UHFFFAOYSA-N 353132 4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(pyridin-3-ylmethyl)aniline::US9796708, Example 364 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353132&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419893 386046871 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696501 Fc1cc(F)cc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C25H23F3N4/c26-17-9-15(10-18(27)11-17)14-31-19-1-2-23(28)21(12-19)20-5-8-30-25-22(20)13-24(32-25)16-3-6-29-7-4-16/h1-2,5,8-13,16,29,31H,3-4,6-7,14H2,(H,30,32) PGEXAXAEEUUDPC-UHFFFAOYSA-N 353133 N-(3,5-difluorobenzyl)-4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 365 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353133&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419979 386046872 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696502 Fc1ccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c(F)c1 InChI=1S/C25H23F3N4/c26-17-2-1-16(23(28)11-17)14-31-18-3-4-22(27)20(12-18)19-7-10-30-25-21(19)13-24(32-25)15-5-8-29-9-6-15/h1-4,7,10-13,15,29,31H,5-6,8-9,14H2,(H,30,32) LOPGMULWTVCYRR-UHFFFAOYSA-N 353134 N-(2,4-difluorobenzyl)-4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 366 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353134&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420514 386046873 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696503 Fc1ccc(F)c(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C25H23F3N4/c26-17-1-3-22(27)16(11-17)14-31-18-2-4-23(28)20(12-18)19-7-10-30-25-21(19)13-24(32-25)15-5-8-29-9-6-15/h1-4,7,10-13,15,29,31H,5-6,8-9,14H2,(H,30,32) ATWSPFQRRDPZBB-UHFFFAOYSA-N 353135 N-(2,5-difluorobenzyl)-4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 367 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353135&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420324 386046874 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696504 Fc1cccc(F)c1CNc1ccc(F)c(c1)-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C25H23F3N4/c26-21-2-1-3-22(27)20(21)14-31-16-4-5-23(28)18(12-16)17-8-11-30-25-19(17)13-24(32-25)15-6-9-29-10-7-15/h1-5,8,11-13,15,29,31H,6-7,9-10,14H2,(H,30,32) CWDUTEYEWFFIFZ-UHFFFAOYSA-N 353136 N-(2,6-difluorobenzyl)-4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 368 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353136&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419925 386046875 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696505 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F InChI=1S/C26H25F3N4/c1-33-8-5-17(6-9-33)25-14-23-21(4-7-30-26(23)32-25)22-13-20(2-3-24(22)29)31-15-16-10-18(27)12-19(28)11-16/h2-4,7,10-14,17,31H,5-6,8-9,15H2,1H3,(H,30,32) MWGIFYHHRVUFIZ-UHFFFAOYSA-N 353137 N-(3,5-difluorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 369 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353137&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897405 386046876 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696506 Fc1ccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)cc1 InChI=1S/C25H24F2N4/c26-18-3-1-16(2-4-18)15-30-19-5-6-23(27)21(13-19)20-9-12-29-25-22(20)14-24(31-25)17-7-10-28-11-8-17/h1-6,9,12-14,17,28,30H,7-8,10-11,15H2,(H,29,31) PMDRZLBXPGVEJA-UHFFFAOYSA-N 353138 4-fluoro-N-(4-fluorobenzyl)-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 370 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353138&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419716 386046877 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696507 NS(=O)(=O)c1ccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)cc1 InChI=1S/C25H26FN5O2S/c26-23-6-3-18(30-15-16-1-4-19(5-2-16)34(27,32)33)13-21(23)20-9-12-29-25-22(20)14-24(31-25)17-7-10-28-11-8-17/h1-6,9,12-14,17,28,30H,7-8,10-11,15H2,(H,29,31)(H2,27,32,33) UHUDLPJYGYWURH-UHFFFAOYSA-N 353139 4-[({4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]benzenesulfonamide::US9796708, Example 371 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353139&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420098 386046878 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696508 Oc1cccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C25H25FN4O/c26-23-5-4-18(29-15-16-2-1-3-19(31)12-16)13-21(23)20-8-11-28-25-22(20)14-24(30-25)17-6-9-27-10-7-17/h1-5,8,11-14,17,27,29,31H,6-7,9-10,15H2,(H,28,30) BIEGSAJZTNZLQQ-UHFFFAOYSA-N 353140 3-[({4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amino)methyl]phenol::US9796708, Example 372 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353140&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419744 386046879 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696509 Fc1ccc(NCc2ccccn2)cc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C24H24FN5/c25-22-5-4-17(29-15-18-3-1-2-9-27-18)13-20(22)19-8-12-28-24-21(19)14-23(30-24)16-6-10-26-11-7-16/h1-5,8-9,12-14,16,26,29H,6-7,10-11,15H2,(H,28,30) ZAKZNDYRHATQTG-UHFFFAOYSA-N 353141 4-fluoro-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(pyridin-2-ylmethyl)aniline::US9796708, Example 373 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353141&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420826 386046880 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696510 CS(=O)(=O)c1cccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCNCC2)c1 InChI=1S/C26H27FN4O2S/c1-34(32,33)20-4-2-3-17(13-20)16-30-19-5-6-24(27)22(14-19)21-9-12-29-26-23(21)15-25(31-26)18-7-10-28-11-8-18/h2-6,9,12-15,18,28,30H,7-8,10-11,16H2,1H3,(H,29,31) IYJUXBLZDNMMKD-UHFFFAOYSA-N 353142 4-fluoro-N-[3-(methylsulfonyl)benzyl]-3-[2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 374 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353142&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421166 386046881 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696511 CS(=O)(=O)Nc1ccc(F)c(c1)-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(C)(=O)=O InChI=1S/C20H23FN4O4S2/c1-30(26,27)24-14-3-4-18(21)16(11-14)15-5-8-22-20-17(15)12-19(23-20)13-6-9-25(10-7-13)31(2,28)29/h3-5,8,11-13,24H,6-7,9-10H2,1-2H3,(H,22,23) MMBADKMFQSUTDX-UHFFFAOYSA-N 353143 N-(4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)methanesulfonamide::US9796708, Example 375 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 470 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353143&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419757 386046882 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696512 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccccc2)ccc1F InChI=1S/C26H27FN4O2S/c1-34(32,33)31-13-10-19(11-14-31)25-16-23-21(9-12-28-26(23)30-25)22-15-20(7-8-24(22)27)29-17-18-5-3-2-4-6-18/h2-9,12,15-16,19,29H,10-11,13-14,17H2,1H3,(H,28,30) NUVYXMOJALKTGK-UHFFFAOYSA-N 353144 N-benzyl-4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 376 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353144&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897447 386046883 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696513 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(Cl)c2)ccc1F InChI=1S/C26H26ClFN4O2S/c1-35(33,34)32-11-8-18(9-12-32)25-15-23-21(7-10-29-26(23)31-25)22-14-20(5-6-24(22)28)30-16-17-3-2-4-19(27)13-17/h2-7,10,13-15,18,30H,8-9,11-12,16H2,1H3,(H,29,31) PLUNMUDFEWHZAT-UHFFFAOYSA-N 353145 N-(3-chlorobenzyl)-4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 377 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 460 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353145&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897300 386046884 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696514 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(F)c2)ccc1F InChI=1S/C26H26F2N4O2S/c1-35(33,34)32-11-8-18(9-12-32)25-15-23-21(7-10-29-26(23)31-25)22-14-20(5-6-24(22)28)30-16-17-3-2-4-19(27)13-17/h2-7,10,13-15,18,30H,8-9,11-12,16H2,1H3,(H,29,31) TZOVEQBYORGCEQ-UHFFFAOYSA-N 353146 4-fluoro-N-(3-fluorobenzyl)-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 378 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353146&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897226 386046885 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696515 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC(C)(C)NC(C)(C)C1 InChI=1S/C23H26FN3O/c1-22(2)12-14(13-23(3,4)27-22)19-11-18-16(8-9-25-21(18)26-19)17-10-15(24)6-7-20(17)28-5/h6-12,27H,13H2,1-5H3,(H,25,26) ZKGFBWRNMKKRPM-UHFFFAOYSA-N 353147 4-(5-fluoro-2-methoxyphenyl)-2-(2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 379 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353147&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420512 386046886 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697308 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC(O)=O)CC1 353940 US9796708, Example 1172::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897301 386047672 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697309 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C1CCC(CC(O)=O)CC1 InChI=1S/C27H32FN3O3/c1-34-25-7-4-19(28)15-22(25)21-8-11-29-27-23(21)16-24(30-27)18-9-12-31(13-10-18)20-5-2-17(3-6-20)14-26(32)33/h4,7-8,11,15-18,20H,2-3,5-6,9-10,12-14H2,1H3,(H,29,30)(H,32,33) NRIFHPNAZSUMQI-UHFFFAOYSA-N 353941 (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}cyclohexyl)acetic acid::US9796708, Example 1173 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353941&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420119 386047673 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697310 COC(=O)C(C)n1cc(cn1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353942 US9796708, Example 1174::methyl 2-(4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1H-pyrazol-1-yl)propanoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353942&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419552 386047674 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697311 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N[C@@H](CC(C)C)C(O)=O InChI=1S/C26H30FN3O3/c1-15(2)12-23(26(31)32)29-18-7-4-16(5-8-18)22-14-21-19(10-11-28-25(21)30-22)20-13-17(27)6-9-24(20)33-3/h4,6,9-11,13-15,18,23,29H,5,7-8,12H2,1-3H3,(H,28,30)(H,31,32)/t18?,23-/m0/s1 OKPZGCMMGOUBGJ-IMMUGOHXSA-N 353943 N-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-L-leucine::US9796708, Example 1175 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353943&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420264 386047675 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697312 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](C)N(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-13-10-14(7-9-25(13)29(3,26)27)19-12-18-16(6-8-23-21(18)24-19)17-11-15(22)4-5-20(17)28-2/h4-6,8,10-13H,7,9H2,1-3H3,(H,23,24)/t13-/m1/s1 PISSTPZYODNWFP-CYBMUJFWSA-N 353944 4-(5-fluoro-2-methoxyphenyl)-2-[(6R)-6-methyl-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1176 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353944&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897198 386047676 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697313 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](C)N(CC(=O)N(C)C)CC1 InChI=1S/C24H27FN4O2/c1-15-11-16(8-10-29(15)14-23(30)28(2)3)21-13-20-18(7-9-26-24(20)27-21)19-12-17(25)5-6-22(19)31-4/h5-7,9,11-13,15H,8,10,14H2,1-4H3,(H,26,27)/t15-/m1/s1 QKRBYSFEJAYDEK-OAHLLOKOSA-N 353945 2-[(6R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide::US9796708, Example 1177 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420533 386047677 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697314 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN([C@H](C)C1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-13-10-14(7-9-25(13)29(3,26)27)19-12-18-16(6-8-23-21(18)24-19)17-11-15(22)4-5-20(17)28-2/h4-8,11-13H,9-10H2,1-3H3,(H,23,24)/t13-/m1/s1 GWWZXSURAHYRGC-CYBMUJFWSA-N 353946 4-(5-fluoro-2-methoxyphenyl)-2-[(2R)-2-methyl-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1178 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897385 386047678 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697315 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)[C@H](C)C1 InChI=1S/C24H27FN4O2/c1-15-11-16(8-10-29(15)14-23(30)28(2)3)21-13-20-18(7-9-26-24(20)27-21)19-12-17(25)5-6-22(19)31-4/h5-9,12-13,15H,10-11,14H2,1-4H3,(H,26,27)/t15-/m1/s1 JXDICWXCJRUIEI-OAHLLOKOSA-N 353947 2-[(2R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-methyl-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide::US9796708, Example 1179 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353947&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421286 386047679 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697316 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)N1CC(O)C1 353948 US9796708, Example 1180::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}(3-hydroxyazetidin-1-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420902 386047680 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697317 CNS(=O)(=O)CC(=O)N1CCC(CC1)c1cc2c(c(F)cnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H24F2N4O4S/c1-25-33(30,31)12-20(29)28-7-5-13(6-8-28)18-10-16-21(17(24)11-26-22(16)27-18)15-9-14(23)3-4-19(15)32-2/h3-4,9-11,13,25H,5-8,12H2,1-2H3,(H,26,27) QPPLMCYQCLXLOE-UHFFFAOYSA-N 353949 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methyl-2-oxoethanesulfonamide::US9796708, Example 1181 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353949&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420257 386047681 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697318 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC(O)=O)CC1)C#N InChI=1S/C22H21FN4O3/c1-30-19-3-2-15(23)8-16(19)21-14(10-24)11-25-22-17(21)9-18(26-22)13-4-6-27(7-5-13)12-20(28)29/h2-3,8-9,11,13H,4-7,12H2,1H3,(H,25,26)(H,28,29) VIOGGRLFSSMMIX-UHFFFAOYSA-N 353950 US9796708, Example 1182::{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413497 386047682 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697319 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC1)C(=O)CC#N)C#N InChI=1S/C23H20FN5O2/c1-31-20-3-2-16(24)10-17(20)22-15(12-26)13-27-23-18(22)11-19(28-23)14-5-8-29(9-6-14)21(30)4-7-25/h2-3,10-11,13-14H,4-6,8-9H2,1H3,(H,27,28) MFTKUWNANBUADM-UHFFFAOYSA-N 353951 2-[1-(cyanoacetyl)piperidin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1183 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353951&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420273 386047683 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697320 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(O)C2)CC1)C#N InChI=1S/C25H26FN5O3/c1-34-22-3-2-17(26)8-19(22)24-16(10-27)11-28-25-20(24)9-21(29-25)15-4-6-30(7-5-15)14-23(33)31-12-18(32)13-31/h2-3,8-9,11,15,18,32H,4-7,12-14H2,1H3,(H,28,29) AMERKECHAXITNX-UHFFFAOYSA-N 353952 4-(5-fluoro-2-methoxyphenyl)-2-{1-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperidin-4-yl}-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1184 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353952&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420389 386047684 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697321 CS(=O)c1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O 353953 4-[5-fluoro-2-(methylsulfinyl)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1185 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419588 386047685 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697322 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(c(C#N)c12)C1=CCC(CC1)C(O)=O 353954 4-[3-cyano-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1186 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353954&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419768 386047686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697323 COc1ccc(F)cc1-c1c(O)cnc2[nH]c(C3=CC4CNCC4C3)c(C#N)c12 353955 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-5-hydroxy-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1187 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353955&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421413 386047687 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697324 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CC4CNCC4C3)c(C#N)c12 353956 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1188 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353956&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420304 386047688 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697325 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C2CC(O)C2)CC1 InChI=1S/C26H30F2N4O3/c1-31(17-10-18(33)11-17)24(34)14-32-7-5-15(6-8-32)22-12-20-25(21(28)13-29-26(20)30-22)19-9-16(27)3-4-23(19)35-2/h3-4,9,12-13,15,17-18,33H,5-8,10-11,14H2,1-2H3,(H,29,30) AXXDLFVMRNZHTA-UHFFFAOYSA-N 353957 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1189 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420363 386047689 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697326 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1CCN(CC(=O)N(C)CCO)CC1)C#N InChI=1S/C25H28FN5O3/c1-30(9-10-32)23(33)15-31-7-5-16(6-8-31)21-12-20-24(17(13-27)14-28-25(20)29-21)19-11-18(26)3-4-22(19)34-2/h3-4,11-12,14,16,32H,5-10,15H2,1-2H3,(H,28,29) GFGGDSDMOLORQX-UHFFFAOYSA-N 353958 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 330 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353958&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419839 386047690 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697327 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)OC(C)(C)C)CC1 InChI=1S/C26H27FN4O3/c1-26(2,3)34-22(32)15-31-11-8-16(9-12-31)24-20(14-28)23-18(7-10-29-25(23)30-24)19-13-17(27)5-6-21(19)33-4/h5-8,10,13H,9,11-12,15H2,1-4H3,(H,29,30) AWSSKDYEMPUARR-UHFFFAOYSA-N 353959 US9796708, Example 1191::tert-butyl {4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353959&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421343 386047691 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697328 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)CS(N)(=O)=O 353960 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-2-oxoethanesulfonamide::US9796708, Example 1192 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353960&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421299 386047692 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697329 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)C(C)S(N)(=O)=O 353961 1-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-1-oxopropane-2-sulfonamide::US9796708, Example 1193 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353961&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420167 386047693 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697330 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)C(=O)CS(=O)(=O)N(C)C 353962 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N,N-dimethyl-2-oxoethanesulfonamide::US9796708, Example 1194 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419959 386047694 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697331 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(=O)OC(C)(C)C)CC2C1 353963 US9796708, Example 1195::tert-butyl {5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353963&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131746441 386047695 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697332 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC[C@@H](O)C2)CC1 InChI=1S/C25H27FN4O3/c1-33-23-3-2-17(26)12-20(23)19-4-8-27-25-21(19)13-22(28-25)16-5-9-29(10-6-16)15-24(32)30-11-7-18(31)14-30/h2-5,8,12-13,18,31H,6-7,9-11,14-15H2,1H3,(H,27,28)/t18-/m1/s1 LOPJDGKGKUAPJO-GOSISDBHSA-N 353964 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[(3R)-3-hydroxypyrrolidin-1-yl]ethanone::US9796708, Example 1196 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353964&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420669 386047696 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697333 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC[C@H](O)C2)CC1 InChI=1S/C25H27FN4O3/c1-33-23-3-2-17(26)12-20(23)19-4-8-27-25-21(19)13-22(28-25)16-5-9-29(10-6-16)15-24(32)30-11-7-18(31)14-30/h2-5,8,12-13,18,31H,6-7,9-11,14-15H2,1H3,(H,27,28)/t18-/m0/s1 LOPJDGKGKUAPJO-SFHVURJKSA-N 353965 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[(3S)-3-hydroxypyrrolidin-1-yl]ethanone::US9796708, Example 1197 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353965&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897407 386047697 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697334 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1ccc(cc1)C(O)=O InChI=1S/C27H22FN3O4/c1-35-24-7-6-19(28)14-21(24)20-8-11-29-25-22(20)15-23(30-25)16-9-12-31(13-10-16)26(32)17-2-4-18(5-3-17)27(33)34/h2-9,11,14-15H,10,12-13H2,1H3,(H,29,30)(H,33,34) YRACZLGJQPODNK-UHFFFAOYSA-N 353966 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)benzoic acid::US9796708, Example 1198 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353966&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420571 386047698 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697335 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cccc(c1)C(O)=O InChI=1S/C27H22FN3O4/c1-35-24-6-5-19(28)14-21(24)20-7-10-29-25-22(20)15-23(30-25)16-8-11-31(12-9-16)26(32)17-3-2-4-18(13-17)27(33)34/h2-8,10,13-15H,9,11-12H2,1H3,(H,29,30)(H,33,34) IONMEYULPRHJEH-UHFFFAOYSA-N 353967 3-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}carbonyl)benzoic acid::US9796708, Example 1199 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353967&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420874 386047699 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697336 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H]2CN(C[C@H]2C1)C(=O)OC(C)(C)C InChI=1S/C26H28FN3O3/c1-26(2,3)33-25(31)30-13-16-9-15(10-17(16)14-30)22-12-21-19(7-8-28-24(21)29-22)20-11-18(27)5-6-23(20)32-4/h5-9,11-12,16-17H,10,13-14H2,1-4H3,(H,28,29)/t16-,17+/m0/s1 OBAKWNXEBRBTJX-DLBZAZTESA-N 353968 US9796708, Example 1200::tert-butyl (3aS,6aR)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrole-2(1H)-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353968&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412043 386047700 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697337 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H]2CN(C[C@@H]2C1)C(=O)OC(C)(C)C InChI=1S/C26H28FN3O3/c1-26(2,3)33-25(31)30-13-16-9-15(10-17(16)14-30)22-12-21-19(7-8-28-24(21)29-22)20-11-18(27)5-6-23(20)32-4/h5-9,11-12,16-17H,10,13-14H2,1-4H3,(H,28,29)/t16-,17+/m1/s1 OBAKWNXEBRBTJX-SJORKVTESA-N 353969 US9796708, Example 1201::tert-butyl (3aR,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrole-2(1H)-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 870 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353969&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90413998 386047701 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697338 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC(CC(O)=O)C1 InChI=1S/C25H26FN3O3/c1-32-23-3-2-17(26)13-20(23)19-4-7-27-25-21(19)14-22(28-25)16-5-8-29(9-6-16)18-10-15(11-18)12-24(30)31/h2-5,7,13-15,18H,6,8-12H2,1H3,(H,27,28)(H,30,31) MCOVHDFUQCRPEW-UHFFFAOYSA-N 353970 (3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobutyl)acetic acid::US9796708, Example 1202 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353970&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421432 386047702 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697339 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1cnn(c1)C(C)C(O)=O 353971 2-(4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1H-pyrazol-1-yl)propanoic acid::US9796708, Example 1203 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353971&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419989 386047703 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697340 CCOC(=O)C1=C(CNCC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H22FN3O3/c1-3-29-22(27)15-6-8-24-12-18(15)19-11-17-14(7-9-25-21(17)26-19)16-10-13(23)4-5-20(16)28-2/h4-5,7,9-11,24H,3,6,8,12H2,1-2H3,(H,25,26) UAJSGOJWVUSWJT-UHFFFAOYSA-N 353972 US9796708, Example 1204::ethyl 5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,6-tetrahydropyridine-4-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 360 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353972&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419719 386047704 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697341 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CN(CC(O)=O)CC2C1 353973 US9796708, Example 1205::{5-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}) acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353973&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412579 386047705 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697342 COCCOCCOCCOCCCN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C29H38FN3O5/c1-34-14-15-37-18-19-38-17-16-36-13-3-10-33-11-7-22(8-12-33)27-21-26-24(6-9-31-29(26)32-27)25-20-23(30)4-5-28(25)35-2/h4-7,9,20-21H,3,8,10-19H2,1-2H3,(H,31,32) OVOONEJAKRLRKH-UHFFFAOYSA-N 353974 4-(5-fluoro-2-methoxyphenyl)-2-[1-(2,5,8,11-tetraoxatetradecan-14-yl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1206 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353974&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420997 386047706 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697343 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CC4CN(CC4C3)S(C)(=O)=O)c(C#N)c12 353975 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-[2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1207 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2300 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353975&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420150 386047707 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697344 CNC(=O)N1CC2CC(=CC2C1)c1[nH]c2ncc(F)c(-c3cc(F)ccc3OC)c2c1C#N 353976 5-[3-cyano-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9796708, Example 1208 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 740 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353976&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420416 386047708 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697345 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC(O)=O)CC2C1)C#N 353977 US9796708, Example 1209::{5-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}) acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353977&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412399 386047709 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697346 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N(C)C2CC(O)C2)CC1 InChI=1S/C27H28FN5O3/c1-32(18-12-19(34)13-18)24(35)15-33-9-6-16(7-10-33)26-22(14-29)25-20(5-8-30-27(25)31-26)21-11-17(28)3-4-23(21)36-2/h3-6,8,11,18-19,34H,7,9-10,12-13,15H2,1-2H3,(H,30,31) XSZXHZDEMZHDQN-UHFFFAOYSA-N 353978 2-{4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1210 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353978&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419741 386047710 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697347 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N3CC(O)C3)CC2C1)C#N 353979 4-(5-fluoro-2-methoxyphenyl)-2-{2-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl}-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1211 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353979&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420740 386047711 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697348 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H24FN5O3/c1-34-21-3-2-16(26)10-19(21)18-4-7-28-25-23(18)20(11-27)24(29-25)15-5-8-30(9-6-15)14-22(33)31-12-17(32)13-31/h2-5,7,10,17,32H,6,8-9,12-14H2,1H3,(H,28,29) ARNFGDWBGNRBEI-UHFFFAOYSA-N 353980 4-(5-fluoro-2-methoxyphenyl)-2-{1-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1212 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353980&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897370 386047712 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697349 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)CCO)CC2C1 353981 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1213 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353981&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420434 386047713 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697350 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)C3CC(O)C3)CC2C1 353982 2-{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1214 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353982&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420238 386047714 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697351 CNC(=O)N1CC2CC(CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 353983 (3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methylhexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9796708, Example 1215 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353983&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208166 386047715 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697352 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC2C1)C(C)=O 353984 1-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]ethanone::US9796708, Example 1216 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353984&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208167 386047716 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697353 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC2C1)C(=O)CO 353985 1-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-2-hydroxyethanone::US9796708, Example 1217 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353985&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208168 386047717 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697354 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC2C1)C(=O)NC#N 353986 (3aR,5r,6aS)-N-cyano-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9796708, Example 1218 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353986&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208169 386047718 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697355 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(=O)N(C)C)CC2C1 353987 2-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-N,N-dimethylacetamide::US9796708, Example 1219 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353987&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208170 386047719 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697356 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(O)CO)CC2C1 353988 3-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propane-1,2-diol::US9796708, Example 1220 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353988&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208171 386047720 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697357 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(N)=O)CC2C1 353989 2-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]acetamide::US9796708, Example 1221 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353989&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208172 386047721 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697358 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC2C1)C(=O)CC#N 353990 3-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-3-oxopropanenitrile::US9796708, Example 1222 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353990&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208173 386047722 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697359 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCC(CC1)C(O)=O InChI=1S/C21H21FN2O3/c1-27-19-7-6-14(22)10-16(19)15-8-9-23-20-17(15)11-18(24-20)12-2-4-13(5-3-12)21(25)26/h6-13H,2-5H2,1H3,(H,23,24)(H,25,26) USGBHDBDOTZXFO-UHFFFAOYSA-N 353991 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohexanecarboxylic acid::US9796708, Example 1223 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353991&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420816 386047723 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696516 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccncc2)ccc1F InChI=1S/C25H26FN5O2S/c1-34(32,33)31-12-7-18(8-13-31)24-15-22-20(6-11-28-25(22)30-24)21-14-19(2-3-23(21)26)29-16-17-4-9-27-10-5-17/h2-6,9-11,14-15,18,29H,7-8,12-13,16H2,1H3,(H,28,30) VJCYSYMEZIFHFM-UHFFFAOYSA-N 353148 4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl})-N-(pyridin-4-ylmethyl)aniline::US9796708, Example 380 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353148&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420361 386046887 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696517 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)C#N)ccc1F InChI=1S/C27H26FN5O2S/c1-36(34,35)33-12-9-20(10-13-33)26-15-24-22(8-11-30-27(24)32-26)23-14-21(6-7-25(23)28)31-17-19-4-2-18(16-29)3-5-19/h2-8,11,14-15,20,31H,9-10,12-13,17H2,1H3,(H,30,32) YOBVWSWLAUSRRI-UHFFFAOYSA-N 353149 4-{[(4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)amino]methyl}benzonitrile::US9796708, Example 381 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353149&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420861 386046888 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696518 Fc1cccc(COc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2=CCNCC2)c1 InChI=1S/C25H21F2N3O/c26-18-3-1-2-16(12-18)15-31-19-4-5-23(27)21(13-19)20-8-11-29-25-22(20)14-24(30-25)17-6-9-28-10-7-17/h1-6,8,11-14,28H,7,9-10,15H2,(H,29,30) QBYLKJJORCOOLM-UHFFFAOYSA-N 353150 4-{2-fluoro-5-[(3-fluorobenzyl)oxy]phenyl}-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 382 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353150&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419922 386046889 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696519 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2nc3ccccc3[nH]2)CC1 InChI=1S/C27H26FN5O/c1-34-25-7-6-18(28)14-20(25)19-8-11-29-27-21(19)15-24(32-27)17-9-12-33(13-10-17)16-26-30-22-4-2-3-5-23(22)31-26/h2-8,11,14-15,17H,9-10,12-13,16H2,1H3,(H,29,32)(H,30,31) JJMKCUFCICQQSS-UHFFFAOYSA-N 353151 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)-1H-benzimidazole::US9796708, Example 383 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353151&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419956 386046890 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696520 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC2CCCO2)CC1 353152 4-(5-fluoro-2-methoxyphenyl)-2-[1-(tetrahydrofuran-2-ylmethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 384 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353152&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420149 386046891 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696521 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC2=CCCOC2)CC1 InChI=1S/C25H28FN3O2/c1-30-24-5-4-19(26)13-21(24)20-6-9-27-25-22(20)14-23(28-25)18-7-10-29(11-8-18)15-17-3-2-12-31-16-17/h3-6,9,13-14,18H,2,7-8,10-12,15-16H2,1H3,(H,27,28) BENPOXCRDPVVKP-UHFFFAOYSA-N 353153 2-[1-(5,6-dihydro-2H-pyran-3-ylmethyl)piperidin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 385 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353153&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419576 386046892 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696522 COc1ccc(CN2CCC(CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)cc1 InChI=1S/C27H28FN3O2/c1-32-21-6-3-18(4-7-21)17-31-13-10-19(11-14-31)25-16-24-22(9-12-29-27(24)30-25)23-15-20(28)5-8-26(23)33-2/h3-9,12,15-16,19H,10-11,13-14,17H2,1-2H3,(H,29,30) SHSXLMWEBANHNT-UHFFFAOYSA-N 353154 4-(5-fluoro-2-methoxyphenyl)-2-[1-(4-methoxybenzyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 386 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353154&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420454 386046893 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696523 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CCN2CCOCC2)CC1 InChI=1S/C25H31FN4O2/c1-31-24-3-2-19(26)16-21(24)20-4-7-27-25-22(20)17-23(28-25)18-5-8-29(9-6-18)10-11-30-12-14-32-15-13-30/h2-4,7,16-18H,5-6,8-15H2,1H3,(H,27,28) DCGPJAOHTGLEOK-UHFFFAOYSA-N 60455 US9073922, 122::US9796708, Example 387 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60455&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419595 313362587 ZINC13125258 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696524 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccc(cc2)C#N)CC1 InChI=1S/C27H25FN4O/c1-33-26-7-6-21(28)14-23(26)22-8-11-30-27-24(22)15-25(31-27)20-9-12-32(13-10-20)17-19-4-2-18(16-29)3-5-19/h2-8,11,14-15,20H,9-10,12-13,17H2,1H3,(H,30,31) OMYNQWFGLJKIKJ-UHFFFAOYSA-N 353156 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)benzonitrile::US9796708, Example 388 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353156&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419729 386046895 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696525 CNC(=O)NCCN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C23H26FN5O2/c1-25-23(30)27-9-12-29-10-6-15(7-11-29)20-14-19-17(5-8-26-22(19)28-20)18-13-16(24)3-4-21(18)31-2/h3-6,8,13-14H,7,9-12H2,1-2H3,(H,26,28)(H2,25,27,30) XARKXYGEWDFHBE-UHFFFAOYSA-N 353157 1-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethyl)-3-methylurea::US9796708, Example 389 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353157&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419827 386046896 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696526 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(C)C)CC1 InChI=1S/C23H28FN3O/c1-15(2)14-27-10-7-16(8-11-27)21-13-20-18(6-9-25-23(20)26-21)19-12-17(24)4-5-22(19)28-3/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3,(H,25,26) FKGJABYKPADQFF-UHFFFAOYSA-N 353158 4-(5-fluoro-2-methoxyphenyl)-2-[1-(2-methylpropyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 390 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353158&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419639 386046897 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696527 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccc(NC(C)=O)cc2)CC1 InChI=1S/C28H29FN4O2/c1-18(34)31-22-6-3-19(4-7-22)17-33-13-10-20(11-14-33)26-16-25-23(9-12-30-28(25)32-26)24-15-21(29)5-8-27(24)35-2/h3-9,12,15-16,20H,10-11,13-14,17H2,1-2H3,(H,30,32)(H,31,34) ZPMKIWURSAKDOH-UHFFFAOYSA-N 353159 N-[4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)phenyl]acetamide::US9796708, Example 391 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353159&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897320 386046898 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696528 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccccn2)CC1 InChI=1S/C25H25FN4O/c1-31-24-6-5-18(26)14-21(24)20-7-11-28-25-22(20)15-23(29-25)17-8-12-30(13-9-17)16-19-4-2-3-10-27-19/h2-7,10-11,14-15,17H,8-9,12-13,16H2,1H3,(H,28,29) CXMKQNXENNOJSF-UHFFFAOYSA-N 353160 4-(5-fluoro-2-methoxyphenyl)-2-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 392 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353160&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420535 386046899 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696529 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccc(cc2)N(C)C)CC1 InChI=1S/C28H31FN4O/c1-32(2)22-7-4-19(5-8-22)18-33-14-11-20(12-15-33)26-17-25-23(10-13-30-28(25)31-26)24-16-21(29)6-9-27(24)34-3/h4-10,13,16-17,20H,11-12,14-15,18H2,1-3H3,(H,30,31) MIKIAPGREKEZHW-UHFFFAOYSA-N 353161 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)-N,N-dimethylaniline::US9796708, Example 393 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353161&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420160 386046900 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696530 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2cnn(c2)C(C)(C)C)CC1 InChI=1S/C27H32FN5O/c1-27(2,3)33-17-18(15-30-33)16-32-11-8-19(9-12-32)24-14-23-21(7-10-29-26(23)31-24)22-13-20(28)5-6-25(22)34-4/h5-7,10,13-15,17,19H,8-9,11-12,16H2,1-4H3,(H,29,31) VWUWQZKXWYGTCS-UHFFFAOYSA-N 353162 2-{1-[(1-tert-butyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 394 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353162&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419863 386046901 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696531 COCCN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C22H26FN3O2/c1-27-12-11-26-9-6-15(7-10-26)20-14-19-17(5-8-24-22(19)25-20)18-13-16(23)3-4-21(18)28-2/h3-5,8,13-15H,6-7,9-12H2,1-2H3,(H,24,25) YXJQLUNLSQAWKV-UHFFFAOYSA-N 353163 4-(5-fluoro-2-methoxyphenyl)-2-[1-(2-methoxyethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 395 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353163&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420901 386046902 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696532 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccncc2)CC1 InChI=1S/C25H25FN4O/c1-31-24-3-2-19(26)14-21(24)20-6-11-28-25-22(20)15-23(29-25)18-7-12-30(13-8-18)16-17-4-9-27-10-5-17/h2-6,9-11,14-15,18H,7-8,12-13,16H2,1H3,(H,28,29) ODDBGPIDIGBYLM-UHFFFAOYSA-N 353164 4-(5-fluoro-2-methoxyphenyl)-2-[1-(pyridin-4-ylmethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 396 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353164&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420489 386046903 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696533 CCN(CC)CCOc1ccc(CN2CCC(CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)cc1 InChI=1S/C32H39FN4O2/c1-4-36(5-2)18-19-39-26-9-6-23(7-10-26)22-37-16-13-24(14-17-37)30-21-29-27(12-15-34-32(29)35-30)28-20-25(33)8-11-31(28)38-3/h6-12,15,20-21,24H,4-5,13-14,16-19,22H2,1-3H3,(H,34,35) SOSHWJABKNCEFQ-UHFFFAOYSA-N 353165 N,N-diethyl-2-[4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)phenoxy]ethanamine::US9796708, Example 397 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353165&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419726 386046904 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696534 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2sc(N)nc2Cl)CC1 InChI=1S/C23H23ClFN5OS/c1-31-19-3-2-14(25)10-16(19)15-4-7-27-22-17(15)11-18(28-22)13-5-8-30(9-6-13)12-20-21(24)29-23(26)32-20/h2-4,7,10-11,13H,5-6,8-9,12H2,1H3,(H2,26,29)(H,27,28) HBPZIWOSOLEZHO-UHFFFAOYSA-N 353166 4-chloro-5-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}methyl)-1,3-thiazol-2-amine::US9796708, Example 398 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353166&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897202 386046905 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696535 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(Cc2ccc3OCOc3c2)CC1 InChI=1S/C27H26FN3O3/c1-32-24-5-3-19(28)13-21(24)20-6-9-29-27-22(20)14-23(30-27)18-7-10-31(11-8-18)15-17-2-4-25-26(12-17)34-16-33-25/h2-6,9,12-14,18H,7-8,10-11,15-16H2,1H3,(H,29,30) ZDOYZGJUYPNVLP-UHFFFAOYSA-N 353167 2-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 399 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353167&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420172 386046906 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696536 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(O)c2)ccc1F InChI=1S/C26H27FN4O3S/c1-35(33,34)31-11-8-18(9-12-31)25-15-23-21(7-10-28-26(23)30-25)22-14-19(5-6-24(22)27)29-16-17-3-2-4-20(32)13-17/h2-7,10,13-15,18,29,32H,8-9,11-12,16H2,1H3,(H,28,30) CSKRTJPJVNTPMK-UHFFFAOYSA-N 353168 3-{[(4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)amino]methyl}phenol::US9796708, Example 400 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353168&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419600 386046907 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696537 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(c2)S(C)(=O)=O)ccc1F InChI=1S/C27H29FN4O4S2/c1-37(33,34)21-5-3-4-18(14-21)17-30-20-6-7-25(28)23(15-20)22-8-11-29-27-24(22)16-26(31-27)19-9-12-32(13-10-19)38(2,35)36/h3-8,11,14-16,19,30H,9-10,12-13,17H2,1-2H3,(H,29,31) ACIUDJPUIMVDDG-UHFFFAOYSA-N 353169 4-fluoro-N-[3-(methylsulfonyl)benzyl]-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 401 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353169&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897362 386046908 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696538 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)C(N)=O)ccc1F InChI=1S/C27H28FN5O3S/c1-37(35,36)33-12-9-18(10-13-33)25-15-23-21(8-11-30-27(23)32-25)22-14-20(6-7-24(22)28)31-16-17-2-4-19(5-3-17)26(29)34/h2-8,11,14-15,18,31H,9-10,12-13,16H2,1H3,(H2,29,34)(H,30,32) VBYPYEUEKWWPKI-UHFFFAOYSA-N 353170 4-{[(4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)amino]methyl})benzamide::US9796708, Example 402 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353170&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420306 386046909 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696539 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(O)cc2)ccc1F InChI=1S/C26H27FN4O3S/c1-35(33,34)31-12-9-18(10-13-31)25-15-23-21(8-11-28-26(23)30-25)22-14-19(4-7-24(22)27)29-16-17-2-5-20(32)6-3-17/h2-8,11,14-15,18,29,32H,9-10,12-13,16H2,1H3,(H,28,30) JTNVFIXOBYJXBF-UHFFFAOYSA-N 353171 4-{[(4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)amino]methyl}phenol::US9796708, Example 403 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420192 386046910 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696540 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCN2CCOCC2)CC1 InChI=1S/C25H29FN4O2/c1-31-24-3-2-19(26)16-21(24)20-4-7-27-25-22(20)17-23(28-25)18-5-8-29(9-6-18)10-11-30-12-14-32-15-13-30/h2-5,7,16-17H,6,8-15H2,1H3,(H,27,28) ZALIFMLEZZMRPD-UHFFFAOYSA-N 353172 4-(5-fluoro-2-methoxyphenyl)-2-{1-[2-(morpholin-4-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 404 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353172&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897356 386046911 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696541 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)Cc1cccc(Cl)c1 InChI=1S/C26H23ClFN3O3S/c1-34-25-6-5-20(28)14-22(25)21-7-10-29-26-23(21)15-24(30-26)18-8-11-31(12-9-18)35(32,33)16-17-3-2-4-19(27)13-17/h2-8,10,13-15H,9,11-12,16H2,1H3,(H,29,30) ZISVWUAFRVBDRK-UHFFFAOYSA-N 353173 2-{1-[(3-chlorobenzyl)sulfonyl]-1,2,3,6-tetrahydropyridin-4-yl}-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 405 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 640 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353173&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897417 386046912 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696542 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCC2CCOCC2)c(F)cc1F InChI=1S/C25H28F2N4O3S/c1-35(32,33)31-8-3-17(4-9-31)23-13-20-18(2-7-28-25(20)30-23)19-12-24(22(27)14-21(19)26)29-15-16-5-10-34-11-6-16/h2-3,7,12-14,16,29H,4-6,8-11,15H2,1H3,(H,28,30) SNWBHJJMZYXGNS-UHFFFAOYSA-N 353174 2,4-difluoro-5-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)aniline::US9796708, Example 406 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353174&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421375 386046913 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696543 Fc1cc(F)c(cc1NCC1CCOCC1)-c1ccnc2[nH]c(cc12)C1=CCNCC1 InChI=1S/C24H26F2N4O/c25-20-13-21(26)23(29-14-15-4-9-31-10-5-15)11-18(20)17-3-8-28-24-19(17)12-22(30-24)16-1-6-27-7-2-16/h1,3,8,11-13,15,27,29H,2,4-7,9-10,14H2,(H,28,30) UCLCFKQXHVKDIU-UHFFFAOYSA-N 353175 2,4-difluoro-N-(tetrahydro-2H-pyran-4-ylmethyl)-5-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 407 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353175&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420252 386046914 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696544 Fc1cccc(CNc2cc(c(F)cc2F)-c2ccnc3[nH]c(cc23)C2=CCNCC2)c1 InChI=1S/C25H21F3N4/c26-17-3-1-2-15(10-17)14-31-24-11-19(21(27)13-22(24)28)18-6-9-30-25-20(18)12-23(32-25)16-4-7-29-8-5-16/h1-4,6,9-13,29,31H,5,7-8,14H2,(H,30,32) UXZMBRBBGQVJFU-UHFFFAOYSA-N 353176 2,4-difluoro-N-(3-fluorobenzyl)-5-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 408 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353176&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420239 386046915 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696545 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F InChI=1S/C26H23F3N4O2S/c1-36(34,35)33-8-5-17(6-9-33)25-14-23-21(4-7-30-26(23)32-25)22-13-20(2-3-24(22)29)31-15-16-10-18(27)12-19(28)11-16/h2-5,7,10-14,31H,6,8-9,15H2,1H3,(H,30,32) SZAQCLOSHIXQOG-UHFFFAOYSA-N 353177 N-(3,5-difluorobenzyl)-4-fluoro-3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 409 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353177&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897279 386046916 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696546 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NC(C)C InChI=1S/C23H25FN4O2/c1-14(2)26-23(29)28-10-7-15(8-11-28)20-13-19-17(6-9-25-22(19)27-20)18-12-16(24)4-5-21(18)30-3/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,25,27)(H,26,29) AABONIZLNAOGJW-UHFFFAOYSA-N 353178 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(propan-2-yl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 410 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353178&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421030 386046917 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696547 CCN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C21H22FN3O/c1-3-25-10-7-14(8-11-25)19-13-18-16(6-9-23-21(18)24-19)17-12-15(22)4-5-20(17)26-2/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,23,24) XLAXFWRJQFAVQC-UHFFFAOYSA-N 353179 2-(1-ethyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 411 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353179&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420378 386046918 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696548 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccccc2)CC1 InChI=1S/C26H24FN3O/c1-31-25-8-7-20(27)15-22(25)21-9-12-28-26-23(21)16-24(29-26)19-10-13-30(14-11-19)17-18-5-3-2-4-6-18/h2-10,12,15-16H,11,13-14,17H2,1H3,(H,28,29) GSONOJAEJHOBFJ-UHFFFAOYSA-N 353180 2-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 412 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353180&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421203 386046919 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696549 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccnc2)ccc1F InChI=1S/C25H26FN5O2S/c1-34(32,33)31-11-7-18(8-12-31)24-14-22-20(6-10-28-25(22)30-24)21-13-19(4-5-23(21)26)29-16-17-3-2-9-27-15-17/h2-6,9-10,13-15,18,29H,7-8,11-12,16H2,1H3,(H,28,30) RNKHENPQQHLSOV-UHFFFAOYSA-N 353181 4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-(pyridin-3-ylmethyl)aniline::US9796708, Example 413 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353181&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419803 386046920 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696550 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F InChI=1S/C26H25F3N4O2S/c1-36(34,35)33-8-5-17(6-9-33)25-14-23-21(4-7-30-26(23)32-25)22-13-20(2-3-24(22)29)31-15-16-10-18(27)12-19(28)11-16/h2-4,7,10-14,17,31H,5-6,8-9,15H2,1H3,(H,30,32) CFYHJSQSOULZPK-UHFFFAOYSA-N 353182 N-(3,5-difluorobenzyl)-4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 414 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353182&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897269 386046921 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696551 CS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(F)c(F)c2)ccc1F InChI=1S/C26H25F3N4O2S/c1-36(34,35)33-10-7-17(8-11-33)25-14-21-19(6-9-30-26(21)32-25)20-13-18(3-5-22(20)27)31-15-16-2-4-23(28)24(29)12-16/h2-6,9,12-14,17,31H,7-8,10-11,15H2,1H3,(H,30,32) GYDULLZAWXURMG-UHFFFAOYSA-N 353183 N-(3,4-difluorobenzyl)-4-fluoro-3-{2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}aniline::US9796708, Example 415 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897416 386046922 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696552 CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(F)c(F)c2)ccc1F InChI=1S/C26H25F3N4/c1-33-10-7-17(8-11-33)25-14-21-19(6-9-30-26(21)32-25)20-13-18(3-5-22(20)27)31-15-16-2-4-23(28)24(29)12-16/h2-6,9,12-14,17,31H,7-8,10-11,15H2,1H3,(H,30,32) YYRZVWUXDZSPJT-UHFFFAOYSA-N 353184 N-(3,4-difluorobenzyl)-4-fluoro-3-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 416 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353184&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897336 386046923 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696553 OCC(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F InChI=1S/C27H25F3N4O2/c28-18-9-16(10-19(29)11-18)14-32-20-1-2-24(30)22(12-20)21-3-6-31-27-23(21)13-25(33-27)17-4-7-34(8-5-17)26(36)15-35/h1-3,6,9-13,17,32,35H,4-5,7-8,14-15H2,(H,31,33) AFBBRQJWPITYSX-UHFFFAOYSA-N 353185 1-[4-(4-{5-[(3,5-difluorobenzyl)amino]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidin-1-yl]-2-hydroxyethanone::US9796708, Example 417 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353185&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420002 386046924 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696554 OCC(O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccnc2)ccc1F 353186 3-[4-(4-{2-fluoro-5-[(pyridin-3-ylmethyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidin-1-yl]propane-1,2-diol::US9796708, Example 418 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353186&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419743 386046925 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696555 OCC(O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccncc2)ccc1F 353187 3-[4-(4-{2-fluoro-5-[(pyridin-4-ylmethyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidin-1-yl]propane-1,2-diol::US9796708, Example 419 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353187&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421108 386046926 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696556 OCC(O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccc(cc2)C#N)ccc1F 353188 4-{[(3-{2-[1-(2,3-dihydroxypropyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-4-fluorophenyl)amino]methyl}benzonitrile::US9796708, Example 420 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353188&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421060 386046927 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696557 OCC(O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(c2)C#N)ccc1F 353189 3-{[(3-{2-[1-(2,3-dihydroxypropyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-4-fluorophenyl)amino]methyl}benzonitrile::US9796708, Example 421 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353189&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420876 386046928 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696558 Fc1ccc(NCc2ccncc2)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(=O)(=O)C1CC1 InChI=1S/C27H28FN5O2S/c28-25-4-1-20(31-17-18-5-10-29-11-6-18)15-23(25)22-7-12-30-27-24(22)16-26(32-27)19-8-13-33(14-9-19)36(34,35)21-2-3-21/h1,4-7,10-12,15-16,19,21,31H,2-3,8-9,13-14,17H2,(H,30,32) HXOAEXKZBWLVNI-UHFFFAOYSA-N 353190 3-{2-[1-(cyclopropylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-4-fluoro-N-(pyridin-4-ylmethyl)aniline::US9796708, Example 422 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353190&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897222 386046929 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696559 Fc1ccc(NCc2ccc(cc2)C#N)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)S(=O)(=O)C1CC1 InChI=1S/C29H28FN5O2S/c30-27-8-5-22(33-18-20-3-1-19(17-31)2-4-20)15-25(27)24-9-12-32-29-26(24)16-28(34-29)21-10-13-35(14-11-21)38(36,37)23-6-7-23/h1-5,8-9,12,15-16,21,23,33H,6-7,10-11,13-14,18H2,(H,32,34) QAWLNNPSWFWGEY-UHFFFAOYSA-N 353191 4-{[(3-{2-[1-(cyclopropylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-4-fluorophenyl)amino]methyl}benzonitrile::US9796708, Example 423 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353191&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419650 386046930 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696560 Fc1cc(F)cc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCN(CC2)S(=O)(=O)C2CC2)c1 InChI=1S/C28H27F3N4O2S/c29-19-11-17(12-20(30)13-19)16-33-21-1-4-26(31)24(14-21)23-5-8-32-28-25(23)15-27(34-28)18-6-9-35(10-7-18)38(36,37)22-2-3-22/h1,4-5,8,11-15,18,22,33H,2-3,6-7,9-10,16H2,(H,32,34) MNTVAEWNSHYIKC-UHFFFAOYSA-N 353192 3-{2-[1-(cyclopropylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-N-(3,5-difluorobenzyl)-4-fluoroaniline::US9796708, Example 424 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 310 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353192&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897392 386046931 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696561 CS(=O)(=O)c1cccc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2CCN(CC2)S(=O)(=O)C2CC2)c1 InChI=1S/C29H31FN4O4S2/c1-39(35,36)23-4-2-3-19(15-23)18-32-21-5-8-27(30)25(16-21)24-9-12-31-29-26(24)17-28(33-29)20-10-13-34(14-11-20)40(37,38)22-6-7-22/h2-5,8-9,12,15-17,20,22,32H,6-7,10-11,13-14,18H2,1H3,(H,31,33) DHVXVUYKFBONNB-UHFFFAOYSA-N 353193 3-{2-[1-(cyclopropylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-4-fluoro-N-[3-(methylsulfonyl)benzyl]aniline::US9796708, Example 425 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353193&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897412 386046932 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696562 NS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(F)c2)ccc1F InChI=1S/C25H25F2N5O2S/c26-18-3-1-2-16(12-18)15-30-19-4-5-23(27)21(13-19)20-6-9-29-25-22(20)14-24(31-25)17-7-10-32(11-8-17)35(28,33)34/h1-6,9,12-14,17,30H,7-8,10-11,15H2,(H,29,31)(H2,28,33,34) OVLGHRSTWXSYDE-UHFFFAOYSA-N 353194 4-(4-{2-fluoro-5-[(3-fluorobenzyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-sulfonamide::US9796708, Example 426 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353194&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419644 386046933 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696563 OCC(O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(F)c2)ccc1F 353195 3-[4-(4-{2-fluoro-5-[(3-fluorobenzyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidin-1-yl]propane-1,2-diol::US9796708, Example 427 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353195&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419894 386046934 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696564 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCCC1 353196 4-(5-fluoro-2-methoxyphenyl)-2-[4-(pyrrolidin-1-yl)cyclohex-1-en-1-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 428 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353196&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419646 386046935 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696565 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(C1)S(C)(=O)=O InChI=1S/C19H18FN3O3S/c1-26-18-4-3-13(20)9-15(18)14-5-7-21-19-16(14)10-17(22-19)12-6-8-23(11-12)27(2,24)25/h3-7,9-10H,8,11H2,1-2H3,(H,21,22) YDLHUKMJGWDZDU-UHFFFAOYSA-N 353197 4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 429 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353197&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421212 386046936 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696566 OCC(O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(OCc2cccc(F)c2)ccc1F 353198 3-[4-(4-{2-fluoro-5-[(3-fluorobenzyl)oxy]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl]propane-1,2-diol::US9796708, Example 430 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353198&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419537 386046937 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696567 OCC(O)CN1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cccc(F)c2)c(F)cc1F 353199 3-[4-(4-{2,4-difluoro-5-[(3-fluorobenzyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl]propane-1,2-diol::US9796708, Example 431 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353199&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420844 386046938 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696568 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2nc3ccccc3[nH]2)CC1 InChI=1S/C27H24FN5O/c1-34-25-7-6-18(28)14-20(25)19-8-11-29-27-21(19)15-24(32-27)17-9-12-33(13-10-17)16-26-30-22-4-2-3-5-23(22)31-26/h2-9,11,14-15H,10,12-13,16H2,1H3,(H,29,32)(H,30,31) OHCQDOMYAMZCIH-UHFFFAOYSA-N 353200 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)-1H-benzimidazole::US9796708, Example 432 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 63.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353200&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897292 386046939 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697360 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCN(CC1)C1CCC(CC(O)=O)CC1 InChI=1S/C28H29FN4O3/c1-36-24-7-4-19(29)15-22(24)21-8-11-31-28-26(21)23(16-30)27(32-28)18-9-12-33(13-10-18)20-5-2-17(3-6-20)14-25(34)35/h4,7-9,11,15,17,20H,2-3,5-6,10,12-14H2,1H3,(H,31,32)(H,34,35) UEAJCDSCXUZRKZ-UHFFFAOYSA-N 353992 (4-{4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl)acetic acid::US9796708, Example 1224 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353992&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420752 386047724 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697361 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)C1CCC(CC(O)=O)CC1 InChI=1S/C27H31F2N3O3/c1-35-24-7-4-18(28)13-20(24)26-21-14-23(31-27(21)30-15-22(26)29)17-8-10-32(11-9-17)19-5-2-16(3-6-19)12-25(33)34/h4,7,13-17,19H,2-3,5-6,8-12H2,1H3,(H,30,31)(H,33,34) ZMHJLQHDDUQJEC-UHFFFAOYSA-N 353993 (4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}cyclohexyl)acetic acid::US9796708, Example 1225 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353993&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419725 386047725 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697362 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCC(CC(O)=O)CC1 353994 US9796708, Example 1226::{4-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353994&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897480 386047726 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697363 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CCO InChI=1S/C21H22FN3O4S/c1-29-20-3-2-15(22)12-17(20)16-4-7-23-21-18(16)13-19(24-21)14-5-8-25(9-6-14)30(27,28)11-10-26/h2-5,7,12-13,26H,6,8-11H2,1H3,(H,23,24) TZEVXCBNIBFNQK-UHFFFAOYSA-N 353995 2-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}sulfonyl)ethanol::US9796708, Example 1227 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353995&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419870 386047727 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697364 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC(C1)C1C(O)CN1C=O 353996 (3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobutyl)(3-hydroxyazetidin-1-yl)methanone::US9796708, Example 1228 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353996&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208174 386047728 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697365 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CC4CN(CC(=O)N(C)C)CC4C3)c(C#N)c12 353997 2-{5-[3-cyano-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N,N-dimethylacetamide::US9796708, Example 1229 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7400 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353997&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420634 386047729 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697366 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@H](C)N(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H27FN4O3/c1-15-9-16(6-8-29(15)14-24(32)30-12-18(31)13-30)22-11-21-19(5-7-27-25(21)28-22)20-10-17(26)3-4-23(20)33-2/h3-5,7,9-11,15,18,31H,6,8,12-14H2,1-2H3,(H,27,28)/t15-/m0/s1 PVYQDNLOXNEODM-HNNXBMFYSA-N 353998 2-[(6S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydropyridin-1(2H)-yl]-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1230 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353998&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421093 386047730 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697367 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C[C@@H](C)N(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H27FN4O3/c1-15-9-16(6-8-29(15)14-24(32)30-12-18(31)13-30)22-11-21-19(5-7-27-25(21)28-22)20-10-17(26)3-4-23(20)33-2/h3-5,7,9-11,15,18,31H,6,8,12-14H2,1-2H3,(H,27,28)/t15-/m1/s1 PVYQDNLOXNEODM-OAHLLOKOSA-N 353999 2-[(6R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydropyridin-1(2H)-yl]-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1231 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353999&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421620 386047731 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697368 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=C(CO)CCNC1 InChI=1S/C20H20FN3O2/c1-26-19-3-2-13(21)8-15(19)14-5-7-23-20-16(14)9-18(24-20)17-10-22-6-4-12(17)11-25/h2-3,5,7-9,22,25H,4,6,10-11H2,1H3,(H,23,24) WJIJHZIONJMABQ-UHFFFAOYSA-N 354000 US9796708, Example 1232::{5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1,2,3,6-tetrahydropyridin-4-yl}methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 440 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354000&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419511 386047732 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697369 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)C1CC(O)C1 InChI=1S/C24H24FN3O3/c1-31-22-3-2-16(25)12-19(22)18-4-7-26-23-20(18)13-21(27-23)14-5-8-28(9-6-14)24(30)15-10-17(29)11-15/h2-5,7,12-13,15,17,29H,6,8-11H2,1H3,(H,26,27) GITHFGZJTLQDAP-UHFFFAOYSA-N 354001 US9796708, Example 1233::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(3-hydroxycyclobutyl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354001&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421091 386047733 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697370 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNC[C@@H]1C InChI=1S/C20H20FN3O/c1-12-11-22-7-5-14(12)18-10-17-15(6-8-23-20(17)24-18)16-9-13(21)3-4-19(16)25-2/h3-6,8-10,12,22H,7,11H2,1-2H3,(H,23,24)/t12-/m0/s1 UJYMZBGSQNGLMN-LBPRGKRZSA-N 354002 4-(5-fluoro-2-methoxyphenyl)-2-[(3R)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1234 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 74.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354002&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419638 386047734 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697371 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCNC[C@H]1C InChI=1S/C20H20FN3O/c1-12-11-22-7-5-14(12)18-10-17-15(6-8-23-20(17)24-18)16-9-13(21)3-4-19(16)25-2/h3-6,8-10,12,22H,7,11H2,1-2H3,(H,23,24)/t12-/m1/s1 UJYMZBGSQNGLMN-GFCCVEGCSA-N 354003 4-(5-fluoro-2-methoxyphenyl)-2-[(3S)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1235 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354003&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420244 386047735 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697372 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)C[C@@H]1C InChI=1S/C24H27FN4O2/c1-15-13-29(14-23(30)28(2)3)10-8-17(15)21-12-20-18(7-9-26-24(20)27-21)19-11-16(25)5-6-22(19)31-4/h5-9,11-12,15H,10,13-14H2,1-4H3,(H,26,27)/t15-/m0/s1 BKJCNKUOOHRKON-HNNXBMFYSA-N 354004 2-[(3R)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-methyl-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide::US9796708, Example 1236 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 870 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354004&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419721 386047736 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697373 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C)C[C@H]1C InChI=1S/C24H27FN4O2/c1-15-13-29(14-23(30)28(2)3)10-8-17(15)21-12-20-18(7-9-26-24(20)27-21)19-11-16(25)5-6-22(19)31-4/h5-9,11-12,15H,10,13-14H2,1-4H3,(H,26,27)/t15-/m1/s1 BKJCNKUOOHRKON-OAHLLOKOSA-N 354005 2-[(3S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-methyl-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide::US9796708, Example 1237 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354005&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420001 386047737 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697374 CNC(=O)[C@@H]1CCCN1C1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C26H29FN4O2/c1-28-26(32)23-4-3-13-31(23)18-8-5-16(6-9-18)22-15-21-19(11-12-29-25(21)30-22)20-14-17(27)7-10-24(20)33-2/h5,7,10-12,14-15,18,23H,3-4,6,8-9,13H2,1-2H3,(H,28,32)(H,29,30)/t18?,23-/m0/s1 QYJGZZQYOHFFSZ-IMMUGOHXSA-N 354006 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-N-methyl-L-prolinamide::US9796708, Example 1238 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 200 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354006&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420480 386047738 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697375 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(=O)N3CC(O)C3)CC2C1 354007 2-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1239 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 290 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354007&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208175 386047739 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697376 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(=O)N3CCC[C@H]3CO)CC2C1 InChI=1S/C28H33FN4O3/c1-36-26-5-4-20(29)11-23(26)22-6-7-30-28-24(22)12-25(31-28)17-9-18-13-32(14-19(18)10-17)15-27(35)33-8-2-3-21(33)16-34/h4-7,11-12,17-19,21,34H,2-3,8-10,13-16H2,1H3,(H,30,31)/t17?,18?,19?,21-/m0/s1 RPQBTOHALWASRO-GJFGYCNFSA-N 354008 2-[(3aR,5S,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1240 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354008&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208176 386047740 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697377 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(=O)N(C)CCO)CC2C1 354009 2-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1241 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354009&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208177 386047741 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697378 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC(=O)N(C)C3CC(O)C3)CC2C1 354010 2-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1242 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 290 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354010&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208178 386047742 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697379 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CC2CN(CC2C1)C(=O)C1CC(O)C1 354011 US9796708, Example 1243::[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl](3-hydroxycyclobutyl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354011&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208179 386047743 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697380 CNS(=O)(=O)CC(=O)N1CC2CC(CC2C1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 354012 2-[(3aR,5r,6aS)-5-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-N-methyl-2-oxoethanesulfonamide::US9796708, Example 1244 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354012&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208180 386047744 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697381 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2)C#N 354013 2-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1245 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354013&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412590 386047745 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697382 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2 354014 2-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1246 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354014&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90411863 386047746 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697383 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2C(=O)NC#N 354015 N-cyano-3-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-ene-8-carboxamide::US9796708, Example 1247 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354015&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419910 386047747 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697384 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)CCO)CC2C1)C#N 354016 2-{5-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1248 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354016&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420623 386047748 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697385 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(O)=O)C#N 354017 US9796708, Example 1249::{3-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}) acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354017&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420490 386047749 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697386 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(O)=O 354018 US9796708, Example 1250::{3-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}) acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354018&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420104 386047750 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697387 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(N)=O)C#N 354019 2-{3-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}acetamide::US9796708, Example 1251 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354019&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897419 386047751 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697388 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCC(CC(O)=O)CC1 InChI=1S/C22H23FN2O3/c1-28-20-7-6-15(23)11-17(20)16-8-9-24-22-18(16)12-19(25-22)14-4-2-13(3-5-14)10-21(26)27/h6-9,11-14H,2-5,10H2,1H3,(H,24,25)(H,26,27) FYBJOPDSQFKVIV-UHFFFAOYSA-N 354020 US9796708, Example 1252::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohexyl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354020&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897235 386047752 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697389 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)C3CC(O)C3)CC2C1)C#N 354021 2-{5-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1253 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354021&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420894 386047753 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697390 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC1)N1CCC[C@H]1C(=O)N(C)C InChI=1S/C27H30F2N4O2/c1-32(2)27(34)23-5-4-12-33(23)18-9-6-16(7-10-18)22-14-20-25(21(29)15-30-26(20)31-22)19-13-17(28)8-11-24(19)35-3/h6,8,11,13-15,18,23H,4-5,7,9-10,12H2,1-3H3,(H,30,31)/t18?,23-/m0/s1 ODWMMHSGCLNECF-IMMUGOHXSA-N 354022 1-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}-N,N-dimethyl-L-prolinamide::US9796708, Example 1254 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354022&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419671 386047754 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697391 COc1ccc(F)cc1-c1ccnc2[nH]c(c(C#N)c12)C1=CCC(CC1)C(O)=O 354023 4-[3-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1255 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354023&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420656 386047755 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697392 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N(C)CCO)C#N 354024 2-{3-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1256 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354024&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421378 386047756 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697393 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N1CCC[C@H]1CO)C#N InChI=1S/C29H30FN5O3/c1-38-26-7-4-19(30)11-23(26)28-18(13-31)14-32-29-24(28)12-25(33-29)17-9-20-5-6-21(10-17)35(20)15-27(37)34-8-2-3-22(34)16-36/h4,7,9,11-12,14,20-22,36H,2-3,5-6,8,10,15-16H2,1H3,(H,32,33)/t20?,21?,22-/m0/s1 WFDSVAUNIAPRON-HRTMPFAESA-N 354025 4-(5-fluoro-2-methoxyphenyl)-2-(8-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}-8-azabicyclo[3.2.1]oct-2-en-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1257 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354025&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420010 386047757 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697394 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N1CC(O)C1)C#N 354026 4-(5-fluoro-2-methoxyphenyl)-2-{8-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-8-azabicyclo[3.2.1]oct-2-en-3-yl}-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US9796708, Example 1258 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354026&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420323 386047758 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697395 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCC(CC(O)=O)CC1)C#N 354027 US9796708, Example 1259::{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 100.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354027&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897429 386047759 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697396 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2 354028 2-(9-azabicyclo[3.3.1]non-2-en-3-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1260 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354028&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420699 386047760 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697397 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2S(C)(=O)=O 354029 4-(5-fluoro-2-methoxyphenyl)-2-[9-(methylsulfonyl)-9-azabicyclo[3.3.1]non-2-en-3-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1261 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354029&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420635 386047761 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697398 CNC(=O)N1C2CCCC1C=C(C2)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC 354030 3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-9-azabicyclo[3.3.1]non-2-ene-9-carboxamide::US9796708, Example 1262 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354030&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421317 386047762 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697399 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2CC(=O)N(C)C 354031 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}-N,N-dimethylacetamide::US9796708, Example 1263 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354031&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420280 386047763 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697400 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2C(=O)CC#N 354032 3-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}-3-oxopropanenitrile::US9796708, Example 1264 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354032&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420968 386047764 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697401 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2C(=O)C1CC(O)C1 354033 US9796708, Example 1265::{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}(3-hydroxycyclobutyl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354033&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420025 386047765 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697402 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N1CC(O)C1 354034 2-{3-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1266 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354034&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419586 386047766 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697403 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N1CCC[C@H]1CO InChI=1S/C28H30F2N4O3/c1-37-25-7-4-17(29)11-21(25)27-22-12-24(32-28(22)31-13-23(27)30)16-9-18-5-6-19(10-16)34(18)14-26(36)33-8-2-3-20(33)15-35/h4,7,9,11-13,18-20,35H,2-3,5-6,8,10,14-15H2,1H3,(H,31,32)/t18?,19?,20-/m0/s1 GYOULPHZBDSUHX-MHJFOBGBSA-N 354035 2-{3-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1267 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354035&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420302 386047767 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697404 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N(C)CCO 354036 2-{3-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1268 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354036&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420903 386047768 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697405 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CC2CCC(C1)N2CC(=O)N[C@H]1CC[C@H](O)CC1 354037 2-{3-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-N-(trans-4-hydroxycyclohexyl)acetamide::US9796708, Example 1269 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354037&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420919 386047769 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697406 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 354038 4-[4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1270 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354038&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419587 386047770 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697407 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 354039 4-[4-(4,5-difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1271 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354039&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421092 386047771 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697408 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 354040 4-[4-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1272 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354040&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421155 386047772 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697409 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(C)(CC1)C(O)=O 354041 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-methylcyclohex-3-ene-1-carboxylic acid::US9796708, Example 1273 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354041&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421064 386047773 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697410 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)N(C)C)CC1 InChI=1S/C24H27FN4O2/c1-28(2)23(30)15-29-11-4-5-16(9-12-29)21-14-20-18(8-10-26-24(20)27-21)19-13-17(25)6-7-22(19)31-3/h5-8,10,13-14H,4,9,11-12,15H2,1-3H3,(H,26,27) MVDRVAPXFDONKL-UHFFFAOYSA-N 354042 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,6,7-tetrahydro-1H-azepin-1-yl}-N,N-dimethylacetamide::US9796708, Example 1274 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354042&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420315 386047774 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697411 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCCN(CC(=O)N(C)C)CC1 354043 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]azepan-1-yl}-N,N-dimethylacetamide::US9796708, Example 1275 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354043&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420948 386047775 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696569 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC2=CCCOC2)CC1 InChI=1S/C25H26FN3O2/c1-30-24-5-4-19(26)13-21(24)20-6-9-27-25-22(20)14-23(28-25)18-7-10-29(11-8-18)15-17-3-2-12-31-16-17/h3-7,9,13-14H,2,8,10-12,15-16H2,1H3,(H,27,28) OOBMCWUIZDVMHU-UHFFFAOYSA-N 353201 2-[1-(5,6-dihydro-2H-pyran-3-ylmethyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 433 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353201&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420738 386046940 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696570 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccc(cc2)N(C)C)CC1 InChI=1S/C28H29FN4O/c1-32(2)22-7-4-19(5-8-22)18-33-14-11-20(12-15-33)26-17-25-23(10-13-30-28(25)31-26)24-16-21(29)6-9-27(24)34-3/h4-11,13,16-17H,12,14-15,18H2,1-3H3,(H,30,31) JUJHOBSWFLETMT-UHFFFAOYSA-N 353202 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)-N,N-dimethylaniline::US9796708, Example 434 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353202&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419807 386046941 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696571 CCN(C)CCOc1ccc(CN2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)cc1 InChI=1S/C31H35FN4O2/c1-4-35(2)17-18-38-25-8-5-22(6-9-25)21-36-15-12-23(13-16-36)29-20-28-26(11-14-33-31(28)34-29)27-19-24(32)7-10-30(27)37-3/h5-12,14,19-20H,4,13,15-18,21H2,1-3H3,(H,33,34) LQBVBUVAZDRUGV-UHFFFAOYSA-N 353203 N,N-diethyl-2-[4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)phenoxy]ethanamine::US9796708, Example 435 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353203&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208106 386046942 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696572 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccncc2)CC1 InChI=1S/C25H23FN4O/c1-31-24-3-2-19(26)14-21(24)20-6-11-28-25-22(20)15-23(29-25)18-7-12-30(13-8-18)16-17-4-9-27-10-5-17/h2-7,9-11,14-15H,8,12-13,16H2,1H3,(H,28,29) VBEOXMFBUFEGAQ-UHFFFAOYSA-N 353204 4-(5-fluoro-2-methoxyphenyl)-2-[1-(pyridin-4-ylmethyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 436 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353204&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420443 386046943 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696573 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2ccc(cc2)C#N)CC1 InChI=1S/C27H23FN4O/c1-33-26-7-6-21(28)14-23(26)22-8-11-30-27-24(22)15-25(31-27)20-9-12-32(13-10-20)17-19-4-2-18(16-29)3-5-19/h2-9,11,14-15H,10,12-13,17H2,1H3,(H,30,31) ORESRHRLEVUDIW-UHFFFAOYSA-N 353205 4-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)benzonitrile::US9796708, Example 437 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353205&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419881 386046944 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696574 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(Cc2sc(N)nc2Cl)CC1 InChI=1S/C23H21ClFN5OS/c1-31-19-3-2-14(25)10-16(19)15-4-7-27-22-17(15)11-18(28-22)13-5-8-30(9-6-13)12-20-21(24)29-23(26)32-20/h2-5,7,10-11H,6,8-9,12H2,1H3,(H2,26,29)(H,27,28) AJFQCNALQSBPOU-UHFFFAOYSA-N 353206 4-chloro-5-({4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methyl)-1,3-thiazol-2-amine::US9796708, Example 438 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353206&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897439 386046945 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696575 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC2CCCO2)CC1 353207 4-(5-fluoro-2-methoxyphenyl)-2-[1-(tetrahydrofuran-2-ylmethyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 439 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353207&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420439 386046946 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696576 Clc1ccc(NCc2cccnc2)cc1-c1ccnc2[nH]c(cc12)C1=CCNC1 InChI=1S/C23H20ClN5/c24-21-4-3-17(28-13-15-2-1-7-25-12-15)10-19(21)18-6-9-27-23-20(18)11-22(29-23)16-5-8-26-14-16/h1-7,9-12,26,28H,8,13-14H2,(H,27,29) LNCDZRQCRUWZOS-UHFFFAOYSA-N 353208 4-chloro-3-[2-(2,5-dihydro-1H-pyrrol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(pyridin-3-ylmethyl)aniline::US9796708, Example 440 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353208&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420180 386046947 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696577 Fc1cccc(CNc2ccc(Cl)c(c2)-c2ccnc3[nH]c(cc23)C2=CCNC2)c1 InChI=1S/C24H20ClFN4/c25-22-5-4-18(29-13-15-2-1-3-17(26)10-15)11-20(22)19-7-9-28-24-21(19)12-23(30-24)16-6-8-27-14-16/h1-7,9-12,27,29H,8,13-14H2,(H,28,30) COYFHZQNYMOZAC-UHFFFAOYSA-N 353209 4-chloro-3-[2-(2,5-dihydro-1H-pyrrol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(3-fluorobenzyl)aniline::US9796708, Example 441 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353209&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419939 386046948 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696578 Clc1ccc(NCC2CCCOC2)cc1-c1ccnc2[nH]c(cc12)C1=CCNC1 353210 4-chloro-3-[2-(2,5-dihydro-1H-pyrrol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(tetrahydro-2H-pyran-3-ylmethyl)aniline::US9796708, Example 442 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421097 386046949 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696579 Clc1ccc(NCC2CCNCC2)cc1-c1ccnc2[nH]c(cc12)C1=CCNC1 InChI=1S/C23H26ClN5/c24-21-2-1-17(28-13-15-3-7-25-8-4-15)11-19(21)18-6-10-27-23-20(18)12-22(29-23)16-5-9-26-14-16/h1-2,5-6,10-12,15,25-26,28H,3-4,7-9,13-14H2,(H,27,29) MBAAMRUPYXHLLX-UHFFFAOYSA-N 353211 4-chloro-3-[2-(2,5-dihydro-1H-pyrrol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(piperidin-4-ylmethyl) aniline::US9796708, Example 443 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353211&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419754 386046950 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696580 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H19F2N3O/c1-25-17-3-2-12(20)8-13(17)18-14-9-16(11-4-6-22-7-5-11)24-19(14)23-10-15(18)21/h2-3,8-11,22H,4-7H2,1H3,(H,23,24) DICGPMBLNBSTFA-UHFFFAOYSA-N 353212 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 444 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90412385 386046951 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696581 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NC1CCCCC1 InChI=1S/C26H29FN4O2/c1-33-24-8-7-18(27)15-21(24)20-9-12-28-25-22(20)16-23(30-25)17-10-13-31(14-11-17)26(32)29-19-5-3-2-4-6-19/h7-10,12,15-16,19H,2-6,11,13-14H2,1H3,(H,28,30)(H,29,32) FBFOCGDTLHNDOU-UHFFFAOYSA-N 353213 N-cyclohexyl-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 445 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353213&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421015 386046952 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696582 COc1ccc(CNC(=O)N2CCC(=CC2)c2cc3c(ccnc3[nH]2)-c2cc(F)ccc2OC)cc1 InChI=1S/C28H27FN4O3/c1-35-21-6-3-18(4-7-21)17-31-28(34)33-13-10-19(11-14-33)25-16-24-22(9-12-30-27(24)32-25)23-15-20(29)5-8-26(23)36-2/h3-10,12,15-16H,11,13-14,17H2,1-2H3,(H,30,32)(H,31,34) BSUMKWKFVAJNTJ-UHFFFAOYSA-N 353214 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(4-methoxybenzyl)-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 446 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 340 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353214&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420681 386046953 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696583 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)Nc1ccccc1 InChI=1S/C26H23FN4O2/c1-33-24-8-7-18(27)15-21(24)20-9-12-28-25-22(20)16-23(30-25)17-10-13-31(14-11-17)26(32)29-19-5-3-2-4-6-19/h2-10,12,15-16H,11,13-14H2,1H3,(H,28,30)(H,29,32) RFTPEHNXNDGGJP-UHFFFAOYSA-N 353215 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-phenyl-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 447 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353215&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897318 386046954 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696584 NS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2ccncc2)ccc1F InChI=1S/C24H25FN6O2S/c25-22-2-1-18(29-15-16-3-8-27-9-4-16)13-20(22)19-5-10-28-24-21(19)14-23(30-24)17-6-11-31(12-7-17)34(26,32)33/h1-5,8-10,13-14,17,29H,6-7,11-12,15H2,(H,28,30)(H2,26,32,33) ONZJVSHWCHMBKN-UHFFFAOYSA-N 353216 4-(4-{2-fluoro-5-[(pyridin-4-ylmethyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-sulfonamide::US9796708, Example 448 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353216&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420429 386046955 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696585 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)S(C)(=O)=O InChI=1S/C20H21F2N3O3S/c1-28-18-4-3-13(21)9-14(18)19-15-10-17(24-20(15)23-11-16(19)22)12-5-7-25(8-6-12)29(2,26)27/h3-4,9-12H,5-8H2,1-2H3,(H,23,24) WPQSRIRRXMFJBO-UHFFFAOYSA-N 353217 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 449 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419884 386046956 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696586 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC(O)CO)CC1 353218 3-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}propane-1,2-diol::US9796708, Example 450 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353218&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420496 386046957 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696587 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1CCN(CC1)C(C)=O InChI=1S/C21H21F2N3O2/c1-12(27)26-7-5-13(6-8-26)18-10-16-20(17(23)11-24-21(16)25-18)15-9-14(22)3-4-19(15)28-2/h3-4,9-11,13H,5-8H2,1-2H3,(H,24,25) CJDNPEBAVLJXGH-UHFFFAOYSA-N 353219 1-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}ethanone::US9796708, Example 451 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353219&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420498 386046958 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696588 OCC(O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F 353220 3-[4-(4-{5-[(3,5-difluorobenzyl)amino]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidin-1-yl]propane-1,2-diol::US9796708, Example 452 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353220&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90422081 386046959 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696589 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)NCCN1CCOCC1 InChI=1S/C26H30FN5O3/c1-34-24-3-2-19(27)16-21(24)20-4-7-28-25-22(20)17-23(30-25)18-5-9-32(10-6-18)26(33)29-8-11-31-12-14-35-15-13-31/h2-5,7,16-17H,6,8-15H2,1H3,(H,28,30)(H,29,33) XVZOFZIYBWAKOI-UHFFFAOYSA-N 353221 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]-3,6-dihydropyridine-1(2H)-carboxamide::US9796708, Example 453 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353221&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897274 386046960 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696590 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(=O)(=O)CCN1CCOCC1 InChI=1S/C25H29FN4O4S/c1-33-24-3-2-19(26)16-21(24)20-4-7-27-25-22(20)17-23(28-25)18-5-8-30(9-6-18)35(31,32)15-12-29-10-13-34-14-11-29/h2-5,7,16-17H,6,8-15H2,1H3,(H,27,28) VCPRPKASMPDNQA-UHFFFAOYSA-N 353222 4-(5-fluoro-2-methoxyphenyl)-2-(1-{[2-(morpholin-4-yl)ethyl]sulfonyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 454 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353222&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420591 386046961 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696591 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1ccccn1 InChI=1S/C25H21FN4O2/c1-32-23-6-5-17(26)14-19(23)18-7-11-28-24-20(18)15-22(29-24)16-8-12-30(13-9-16)25(31)21-4-2-3-10-27-21/h2-8,10-11,14-15H,9,12-13H2,1H3,(H,28,29) ZCZCVCKAVHOUCM-UHFFFAOYSA-N 353223 US9796708, Example 455::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(pyridin-2-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353223&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897431 386046962 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696592 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cccnc1 InChI=1S/C25H21FN4O2/c1-32-23-5-4-18(26)13-20(23)19-6-10-28-24-21(19)14-22(29-24)16-7-11-30(12-8-16)25(31)17-3-2-9-27-15-17/h2-7,9-10,13-15H,8,11-12H2,1H3,(H,28,29) NQIAMJFOSGXNDM-UHFFFAOYSA-N 353224 US9796708, Example 456::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(pyridin-3-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353224&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420556 386046963 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696593 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1ccncc1 InChI=1S/C25H21FN4O2/c1-32-23-3-2-18(26)14-20(23)19-6-11-28-24-21(19)15-22(29-24)16-7-12-30(13-8-16)25(31)17-4-9-27-10-5-17/h2-7,9-11,14-15H,8,12-13H2,1H3,(H,28,29) PZTIJXUEVYHRQL-UHFFFAOYSA-N 353225 US9796708, Example 457::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(pyridin-4-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353225&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421159 386046964 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696594 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cnccn1 InChI=1S/C24H20FN5O2/c1-32-22-3-2-16(25)12-18(22)17-4-7-28-23-19(17)13-20(29-23)15-5-10-30(11-6-15)24(31)21-14-26-8-9-27-21/h2-5,7-9,12-14H,6,10-11H2,1H3,(H,28,29) VAGXWQQHMTYAIN-UHFFFAOYSA-N 353226 US9796708, Example 458::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(pyrazin-2-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 83.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353226&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420675 386046965 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696595 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1ccncn1 InChI=1S/C23H20FN5O/c1-30-21-3-2-16(24)12-18(21)17-4-9-26-23-19(17)13-20(28-23)15-6-10-29(11-7-15)22-5-8-25-14-27-22/h2-6,8-9,12-14H,7,10-11H2,1H3,(H,26,28) AUSMXPPKRNFVQL-UHFFFAOYSA-N 353227 4-(5-fluoro-2-methoxyphenyl)-2-[1-(pyrimidin-4-yl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 459 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353227&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897488 386046966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696596 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1ccnc(C)n1 InChI=1S/C24H22FN5O/c1-15-26-10-6-23(28-15)30-11-7-16(8-12-30)21-14-20-18(5-9-27-24(20)29-21)19-13-17(25)3-4-22(19)31-2/h3-7,9-10,13-14H,8,11-12H2,1-2H3,(H,27,29) CSERKDRHCRIPQK-UHFFFAOYSA-N 353228 4-(5-fluoro-2-methoxyphenyl)-2-[1-(2-methylpyrimidin-4-yl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 460 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 470 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353228&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419695 386046967 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696597 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)c1cc(ncn1)C(F)(F)F InChI=1S/C24H19F4N5O/c1-34-20-3-2-15(25)10-17(20)16-4-7-29-23-18(16)11-19(32-23)14-5-8-33(9-6-14)22-12-21(24(26,27)28)30-13-31-22/h2-5,7,10-13H,6,8-9H2,1H3,(H,29,32) VOWBLBNZLSHEJF-UHFFFAOYSA-N 353229 4-(5-fluoro-2-methoxyphenyl)-2-{1-[6-(trifluoromethyl)pyrimidin-4-yl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 461 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353229&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897298 386046968 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696598 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CCN1CCCCC1 InChI=1S/C27H31FN4O2/c1-34-25-6-5-20(28)17-22(25)21-7-11-29-27-23(21)18-24(30-27)19-8-15-32(16-9-19)26(33)10-14-31-12-3-2-4-13-31/h5-8,11,17-18H,2-4,9-10,12-16H2,1H3,(H,29,30) VHMJRSGURTUOHO-UHFFFAOYSA-N 353230 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-3-(piperidin-1-yl)propan-1-one::US9796708, Example 462 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353230&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897316 386046969 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696599 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cn[nH]c1 InChI=1S/C23H20FN5O2/c1-31-21-3-2-16(24)10-18(21)17-4-7-25-22-19(17)11-20(28-22)14-5-8-29(9-6-14)23(30)15-12-26-27-13-15/h2-5,7,10-13H,6,8-9H2,1H3,(H,25,28)(H,26,27) OZKYVVFNMFNSCY-UHFFFAOYSA-N 353231 US9796708, Example 463::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(1H-pyrazol-4-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353231&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419497 386046970 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696600 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cscn1 InChI=1S/C23H19FN4O2S/c1-30-21-3-2-15(24)10-17(21)16-4-7-25-22-18(16)11-19(27-22)14-5-8-28(9-6-14)23(29)20-12-31-13-26-20/h2-5,7,10-13H,6,8-9H2,1H3,(H,25,27) TVAXVUJLRIGNDR-UHFFFAOYSA-N 353232 US9796708, Example 464::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(1,3-thiazol-4-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 79.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353232&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420537 386046971 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696601 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1c(C)noc1C InChI=1S/C25H23FN4O3/c1-14-23(15(2)33-29-14)25(31)30-10-7-16(8-11-30)21-13-20-18(6-9-27-24(20)28-21)19-12-17(26)4-5-22(19)32-3/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,27,28) QDWNDRUEFUKTJR-UHFFFAOYSA-N 353233 (3,5-dimethyl-1,2-oxazol-4-yl) {4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methanone::US9796708, Example 465 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353233&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208107 386046972 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696602 COc1ccc(Cl)c(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20ClN3O3S/c1-27-14-3-4-18(21)16(11-14)15-5-8-22-20-17(15)12-19(23-20)13-6-9-24(10-7-13)28(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) HZDNGXOSQCTLOL-UHFFFAOYSA-N 353234 4-(2-chloro-5-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 466 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353234&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420203 386046973 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696603 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(F)c(F)c1F InChI=1S/C19H16F3N3O2S/c1-28(26,27)25-8-5-11(6-9-25)16-10-14-12(4-7-23-19(14)24-16)13-2-3-15(20)18(22)17(13)21/h2-5,7,10H,6,8-9H2,1H3,(H,23,24) KUROHDVCHHZQRT-UHFFFAOYSA-N 353235 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(2,3,4-trifluorophenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 467 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353235&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421058 386046974 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696604 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(OC(F)(F)F)c1 InChI=1S/C20H18F3N3O3S/c1-30(27,28)26-9-6-13(7-10-26)18-12-17-16(5-8-24-19(17)25-18)14-3-2-4-15(11-14)29-20(21,22)23/h2-6,8,11-12H,7,9-10H2,1H3,(H,24,25) RJSOCHUJDHVIDU-UHFFFAOYSA-N 353236 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-[3-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 468 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353236&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419783 386046975 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696605 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCNC(=O)CN(C)C)CC1 InChI=1S/C25H30FN5O2/c1-30(2)16-24(32)27-10-13-31-11-7-17(8-12-31)22-15-21-19(6-9-28-25(21)29-22)20-14-18(26)4-5-23(20)33-3/h4-7,9,14-15H,8,10-13,16H2,1-3H3,(H,27,32)(H,28,29) ATMLWAVSDGOTHG-UHFFFAOYSA-N 353237 N-(2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethyl)-N2,N2-dimethylglycinamide::US9796708, Example 469 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353237&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419847 386046976 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696606 COc1ccc(cc1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H21N3O3S/c1-26-16-5-3-14(4-6-16)17-7-10-21-20-18(17)13-19(22-20)15-8-11-23(12-9-15)27(2,24)25/h3-8,10,13H,9,11-12H2,1-2H3,(H,21,22) IUGVVTHZTVFHOB-UHFFFAOYSA-N 353238 4-(4-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 470 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353238&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420301 386046977 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696607 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(F)c(F)c1 InChI=1S/C19H17F2N3O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-15-14(4-7-22-19(15)23-18)13-2-3-16(20)17(21)10-13/h2-5,7,10-11H,6,8-9H2,1H3,(H,22,23) GRHAPBRXZOQFCV-UHFFFAOYSA-N 353239 4-(3,4-difluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 471 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353239&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420266 386046978 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696608 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccccc1OC(F)(F)F InChI=1S/C20H18F3N3O3S/c1-30(27,28)26-10-7-13(8-11-26)17-12-16-14(6-9-24-19(16)25-17)15-4-2-3-5-18(15)29-20(21,22)23/h2-7,9,12H,8,10-11H2,1H3,(H,24,25) CACIVYOSNOXYHB-UHFFFAOYSA-N 353240 2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-[2-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 472 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353240&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420701 386046979 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696609 CC(C)Oc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-14(2)29-21-5-4-16(23)12-18(21)17-6-9-24-22-19(17)13-20(25-22)15-7-10-26(11-8-15)30(3,27)28/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,24,25) FWYGVLXKGOIMLI-UHFFFAOYSA-N 353241 4-[5-fluoro-2-(propan-2-yloxy)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 473 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353241&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419642 386046980 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696610 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC1CC1 InChI=1S/C22H22FN3O3S/c1-30(27,28)26-10-7-14(8-11-26)20-13-19-17(6-9-24-22(19)25-20)18-12-15(23)2-5-21(18)29-16-3-4-16/h2,5-7,9,12-13,16H,3-4,8,10-11H2,1H3,(H,24,25) SRLQPYHEKSLLAH-UHFFFAOYSA-N 353242 4-[2-(cyclopropyloxy)-5-fluorophenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 474 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353242&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420115 386046981 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696611 CCOc1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C21H22FN3O3S/c1-3-28-20-5-4-15(12-18(20)22)16-6-9-23-21-17(16)13-19(24-21)14-7-10-25(11-8-14)29(2,26)27/h4-7,9,12-13H,3,8,10-11H2,1-2H3,(H,23,24) CHDXBXBCBTYSQI-UHFFFAOYSA-N 353243 4-(4-ethoxy-3-fluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 475 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 470 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353243&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420729 386046982 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696612 NS(=O)(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(NCc2cc(F)cc(F)c2)ccc1F InChI=1S/C25H24F3N5O2S/c26-17-9-15(10-18(27)11-17)14-31-19-1-2-23(28)21(12-19)20-3-6-30-25-22(20)13-24(32-25)16-4-7-33(8-5-16)36(29,34)35/h1-3,6,9-13,16,31H,4-5,7-8,14H2,(H,30,32)(H2,29,34,35) QXCMYDWXEVKCEB-UHFFFAOYSA-N 353244 4-(4-{5-[(3,5-difluorobenzyl)amino]-2-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-sulfonamide::US9796708, Example 476 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 70.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353244&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420819 386046983 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696613 Cc1cc(ccc1Cl)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20ClN3O2S/c1-13-11-15(3-4-18(13)21)16-5-8-22-20-17(16)12-19(23-20)14-6-9-24(10-7-14)27(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) RZMBFRZWRUQDKU-UHFFFAOYSA-N 353245 4-(4-chloro-3-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 477 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353245&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419926 386046984 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696614 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1ccc(F)c(Cl)c1 InChI=1S/C19H17ClFN3O2S/c1-27(25,26)24-8-5-12(6-9-24)18-11-15-14(4-7-22-19(15)23-18)13-2-3-17(21)16(20)10-13/h2-5,7,10-11H,6,8-9H2,1H3,(H,22,23) ZPQSGPXJWAOOLX-UHFFFAOYSA-N 353246 4-(3-chloro-4-fluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 478 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353246&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419846 386046985 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696615 CN(C)C(=O)c1cccc(c1)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24N4O3S/c1-25(2)22(27)17-6-4-5-16(13-17)18-7-10-23-21-19(18)14-20(24-21)15-8-11-26(12-9-15)30(3,28)29/h4-8,10,13-14H,9,11-12H2,1-3H3,(H,23,24) BBXHWPJIEAKUMV-UHFFFAOYSA-N 353247 N,N-dimethyl-3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzamide::US9796708, Example 479 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1900 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353247&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419556 386046986 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696616 Cc1cc(ccc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C20H20FN3O2S/c1-13-11-15(3-4-18(13)21)16-5-8-22-20-17(16)12-19(23-20)14-6-9-24(10-7-14)27(2,25)26/h3-6,8,11-12H,7,9-10H2,1-2H3,(H,22,23) KBELGGRTIXAKGS-UHFFFAOYSA-N 353248 4-(4-fluoro-3-methylphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 480 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353248&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419636 386046987 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696617 CC(C)Oc1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C22H24FN3O3S/c1-14(2)29-21-5-4-16(12-19(21)23)17-6-9-24-22-18(17)13-20(25-22)15-7-10-26(11-8-15)30(3,27)28/h4-7,9,12-14H,8,10-11H2,1-3H3,(H,24,25) GXJMUJVMDTWMDR-UHFFFAOYSA-N 353249 4-[3-fluoro-4-(propan-2-yloxy)phenyl]-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 481 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2800 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353249&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420393 386046988 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696618 CCCCOc1ccc(cc1F)-c1ccnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O InChI=1S/C23H26FN3O3S/c1-3-4-13-30-22-6-5-17(14-20(22)24)18-7-10-25-23-19(18)15-21(26-23)16-8-11-27(12-9-16)31(2,28)29/h5-8,10,14-15H,3-4,9,11-13H2,1-2H3,(H,25,26) PSNAFTYSBOOEHN-UHFFFAOYSA-N 353250 4-(4-butoxy-3-fluorophenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 482 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353250&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420801 386046989 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696619 CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cccc(c1)C(=O)N1CCOCC1 InChI=1S/C24H26N4O4S/c1-33(30,31)28-9-6-17(7-10-28)22-16-21-20(5-8-25-23(21)26-22)18-3-2-4-19(15-18)24(29)27-11-13-32-14-12-27/h2-6,8,15-16H,7,9-14H2,1H3,(H,25,26) CARGTJOYRGATLS-UHFFFAOYSA-N 353251 (3-{2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}phenyl)(morpholin-4-yl)methanone::US9796708, Example 483 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353251&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421712 386046990 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696620 Fc1cc(F)cc(CNc2ccc(F)c(c2)-c2ccnc3[nH]c(cc23)C2=CCNCC2)c1 InChI=1S/C25H21F3N4/c26-17-9-15(10-18(27)11-17)14-31-19-1-2-23(28)21(12-19)20-5-8-30-25-22(20)13-24(32-25)16-3-6-29-7-4-16/h1-3,5,8-13,29,31H,4,6-7,14H2,(H,30,32) FZFWVJXKYSMWFN-UHFFFAOYSA-N 353252 N-(3,5-difluorobenzyl)-4-fluoro-3-[2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]aniline::US9796708, Example 484 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353252&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420214 386046991 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 696621 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCNC1 InChI=1S/C19H18FN3O/c1-24-18-5-4-13(20)9-15(18)14-6-8-22-19-16(14)10-17(23-19)12-3-2-7-21-11-12/h3-6,8-10,21H,2,7,11H2,1H3,(H,22,23) YFYSQSYEQXVGJJ-UHFFFAOYSA-N 353253 4-(5-fluoro-2-methoxyphenyl)-2-(1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 485 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=353253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=353253&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421355 386046992 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697412 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(O)=O)CC1 InChI=1S/C22H22FN3O3/c1-29-20-5-4-15(23)11-17(20)16-6-8-24-22-18(16)12-19(25-22)14-3-2-9-26(10-7-14)13-21(27)28/h3-6,8,11-12H,2,7,9-10,13H2,1H3,(H,24,25)(H,27,28) BUJJOGURYSLRGU-UHFFFAOYSA-N 354044 US9796708, Example 1276::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,6,7-tetrahydro-1H-azepin-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354044&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897442 386047776 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697413 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)N2CC(O)C2)CC1 InChI=1S/C25H27FN4O3/c1-33-23-5-4-17(26)11-20(23)19-6-8-27-25-21(19)12-22(28-25)16-3-2-9-29(10-7-16)15-24(32)30-13-18(31)14-30/h3-6,8,11-12,18,31H,2,7,9-10,13-15H2,1H3,(H,27,28) ALZXGEPXNOVHJE-UHFFFAOYSA-N 354045 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,6,7-tetrahydro-1H-azepin-1-yl}-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1277 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354045&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419800 386047777 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697414 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CN(C1)C(=O)OC(C)(C)C InChI=1S/C27H31FN4O3/c1-27(2,3)35-26(33)32-15-19(16-32)31-11-8-17(9-12-31)23-14-22-20(7-10-29-25(22)30-23)21-13-18(28)5-6-24(21)34-4/h5-8,10,13-14,19H,9,11-12,15-16H2,1-4H3,(H,29,30) UUSMOPZQJHZCTI-UHFFFAOYSA-N 354046 US9796708, Example 1278::tert-butyl 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}azetidine-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 370 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354046&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420775 386047778 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697415 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C1CN(C1)C(=O)OC(C)(C)C InChI=1S/C27H33FN4O3/c1-27(2,3)35-26(33)32-15-19(16-32)31-11-8-17(9-12-31)23-14-22-20(7-10-29-25(22)30-23)21-13-18(28)5-6-24(21)34-4/h5-7,10,13-14,17,19H,8-9,11-12,15-16H2,1-4H3,(H,29,30) YGSYQDHREYWERW-UHFFFAOYSA-N 354047 US9796708, Example 1279::tert-butyl 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}azetidine-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1510 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354047&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897415 386047779 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697416 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC(O)=O)CC1 354048 US9796708, Example 1280::{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354048&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897482 386047780 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697417 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CNC1 InChI=1S/C22H23FN4O/c1-28-21-3-2-15(23)10-18(21)17-4-7-25-22-19(17)11-20(26-22)14-5-8-27(9-6-14)16-12-24-13-16/h2-5,7,10-11,16,24H,6,8-9,12-13H2,1H3,(H,25,26) RYKIKKCRZQHISI-UHFFFAOYSA-N 354049 2-[1-(azetidin-3-yl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1281 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354049&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420525 386047781 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697418 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C1CNC1 InChI=1S/C22H25FN4O/c1-28-21-3-2-15(23)10-18(21)17-4-7-25-22-19(17)11-20(26-22)14-5-8-27(9-6-14)16-12-24-13-16/h2-4,7,10-11,14,16,24H,5-6,8-9,12-13H2,1H3,(H,25,26) CZKVVJGRIZBXFO-UHFFFAOYSA-N 354050 2-[1-(azetidin-3-yl)piperidin-4-yl]-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1282 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354050&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419700 386047782 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697419 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cc(OCc2ccccc2)no1 InChI=1S/C30H25FN4O4/c1-37-26-8-7-21(31)15-23(26)22-9-12-32-29-24(22)16-25(33-29)20-10-13-35(14-11-20)30(36)27-17-28(34-39-27)38-18-19-5-3-2-4-6-19/h2-10,12,15-17H,11,13-14,18H2,1H3,(H,32,33) FXDODVZPQLBENP-UHFFFAOYSA-N 354051 US9796708, Example 1283::[3-(benzyloxy)-1,2-oxazol-5-yl]{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2600 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354051&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897277 386047783 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697420 COc1ccc(F)cc1-c1c(cnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O)C#N 354052 4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1284 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354052&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419706 386047784 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697421 COc1ccc(F)cc1-c1ccnc2[nH]c(N3CCN(CC3)C(=O)OC(C)(C)C)c([N+]([O-])=O)c12 InChI=1S/C23H26FN5O5/c1-23(2,3)34-22(30)28-11-9-27(10-12-28)21-19(29(31)32)18-15(7-8-25-20(18)26-21)16-13-14(24)5-6-17(16)33-4/h5-8,13H,9-12H2,1-4H3,(H,25,26) CDQXPLLLMJALQJ-UHFFFAOYSA-N 354053 US9796708, Example 1285::tert-butyl 4-[4-(5-fluoro-2-methoxyphenyl)-3-nitro-1H-pyrrolo[2,3-b]pyridin-2-yl]piperazine-1-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 250 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354053&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420677 386047785 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697422 COc1ccc(F)cc1-c1ccnc2[nH]c(N3CCNCC3)c([N+]([O-])=O)c12 InChI=1S/C18H18FN5O3/c1-27-14-3-2-11(19)10-13(14)12-4-5-21-17-15(12)16(24(25)26)18(22-17)23-8-6-20-7-9-23/h2-5,10,20H,6-9H2,1H3,(H,21,22) BGIRZABJTGUNAP-UHFFFAOYSA-N 354054 4-(5-fluoro-2-methoxyphenyl)-3-nitro-2-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1286 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354054&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420880 386047786 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697423 CNC(=O)N1CCN(CC1)c1[nH]c2nccc(-c3cc(F)ccc3OC)c2c1[N+]([O-])=O InChI=1S/C20H21FN6O4/c1-22-20(28)26-9-7-25(8-10-26)19-17(27(29)30)16-13(5-6-23-18(16)24-19)14-11-12(21)3-4-15(14)31-2/h3-6,11H,7-10H2,1-2H3,(H,22,28)(H,23,24) ZTDFSMYPWRDPLU-UHFFFAOYSA-N 354055 4-[4-(5-fluoro-2-methoxyphenyl)-3-nitro-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methylpiperazine-1-carboxamide::US9796708, Example 1287 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354055&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420089 386047787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697424 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CN(C1)S(C)(=O)=O InChI=1S/C23H25FN4O3S/c1-31-22-4-3-16(24)11-19(22)18-5-8-25-23-20(18)12-21(26-23)15-6-9-27(10-7-15)17-13-28(14-17)32(2,29)30/h3-6,8,11-12,17H,7,9-10,13-14H2,1-2H3,(H,25,26) PJDVVCLHLHBBAN-UHFFFAOYSA-N 354056 4-(5-fluoro-2-methoxyphenyl)-2-{1-[1-(methylsulfonyl)azetidin-3-yl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1288 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354056&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897352 386047788 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697425 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC1)C1CN(C1)S(C)(=O)=O InChI=1S/C23H27FN4O3S/c1-31-22-4-3-16(24)11-19(22)18-5-8-25-23-20(18)12-21(26-23)15-6-9-27(10-7-15)17-13-28(14-17)32(2,29)30/h3-5,8,11-12,15,17H,6-7,9-10,13-14H2,1-2H3,(H,25,26) JJKVRJYZUITUET-UHFFFAOYSA-N 354057 4-(5-fluoro-2-methoxyphenyl)-2-{1-[1-(methylsulfonyl)azetidin-3-yl]piperidin-4-yl}-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1289 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354057&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419677 386047789 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697426 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)N(C)C2CC(O)C2)CC1 InChI=1S/C27H31FN4O3/c1-31(19-13-20(33)14-19)26(34)16-32-10-3-4-17(8-11-32)24-15-23-21(7-9-29-27(23)30-24)22-12-18(28)5-6-25(22)35-2/h4-7,9,12,15,19-20,33H,3,8,10-11,13-14,16H2,1-2H3,(H,29,30) RDIKRUMDZWXXLB-UHFFFAOYSA-N 354058 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,6,7-tetrahydro-1H-azepin-1-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1290 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354058&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420999 386047790 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697427 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)N(C)CCO)CC1 InChI=1S/C25H29FN4O3/c1-29(12-13-31)24(32)16-30-10-3-4-17(8-11-30)22-15-21-19(7-9-27-25(21)28-22)20-14-18(26)5-6-23(20)33-2/h4-7,9,14-15,31H,3,8,10-13,16H2,1-2H3,(H,27,28) ONBWHIIDJIDPMH-UHFFFAOYSA-N 354059 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,6,7-tetrahydro-1H-azepin-1-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1291 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354059&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419801 386047791 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697428 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C27H31FN4O3/c1-35-25-7-6-19(28)14-22(25)21-8-10-29-27-23(21)15-24(30-27)18-4-2-11-31(13-9-18)16-26(34)32-12-3-5-20(32)17-33/h4,6-8,10,14-15,20,33H,2-3,5,9,11-13,16-17H2,1H3,(H,29,30)/t20-/m0/s1 IIONNASMPNLLDL-FQEVSTJZSA-N 354060 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,3,6,7-tetrahydro-1H-azepin-1-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]thanone::US9796708, Example 1292 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354060&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419978 386047792 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697429 COc1ccc(F)cc1-c1c(OC)cnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O 354061 4-(5-fluoro-2-methoxyphenyl)-5-methoxy-2-[2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1293 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354061&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420502 386047793 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697430 COc1ccc(F)cc1-c1c(OC)cnc2[nH]c(cc12)C1=CC2CN(CC(=O)N(C)C)CC2C1 354062 2-{5-[4-(5-fluoro-2-methoxyphenyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl}-N,N-dimethylacetamide::US9796708, Example 1294 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354062&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420862 386047794 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697431 COc1cc(F)c(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 354063 4-[4-(4,5-difluoro-2-methoxyphenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1295 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354063&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420247 386047795 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697432 COc1cc(F)ccc1-c1c(F)cnc2[nH]c(cc12)C1=CCC(CC1)C(O)=O 354064 4-[5-fluoro-4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-ene-1-carboxylic acid::US9796708, Example 1296 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354064&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421090 386047796 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697433 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)N1CCN(CC(O)=O)CC1 354065 (4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]cyclohex-3-en-1-yl}piperazin-1-yl)acetic acid::US9796708, Example 1297 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354065&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420342 386047797 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697434 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)C2CC(O)C2)CC1 InChI=1S/C26H28F2N4O3/c1-31(17-10-18(33)11-17)24(34)14-32-7-5-15(6-8-32)22-12-20-25(21(28)13-29-26(20)30-22)19-9-16(27)3-4-23(19)35-2/h3-5,9,12-13,17-18,33H,6-8,10-11,14H2,1-2H3,(H,29,30) DWFFGBFFYYJDCU-UHFFFAOYSA-N 354066 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1298 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354066&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420045 386047798 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697435 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N(C)CCO)CC1 InChI=1S/C24H26F2N4O3/c1-29(9-10-31)22(32)14-30-7-5-15(6-8-30)20-12-18-23(19(26)13-27-24(18)28-20)17-11-16(25)3-4-21(17)33-2/h3-5,11-13,31H,6-10,14H2,1-2H3,(H,27,28) FKZDESUIPUQBIX-UHFFFAOYSA-N 354067 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1299 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354067&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897468 386047799 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697436 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1 InChI=1S/C26H28F2N4O3/c1-35-23-5-4-17(27)11-19(23)25-20-12-22(30-26(20)29-13-21(25)28)16-6-9-31(10-7-16)14-24(34)32-8-2-3-18(32)15-33/h4-6,11-13,18,33H,2-3,7-10,14-15H2,1H3,(H,29,30)/t18-/m0/s1 ZRXIWZFVJPAHQP-SFHVURJKSA-N 354068 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1300 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354068&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420224 386047800 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697437 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC(=O)N[C@H]2CC[C@H](O)CC2)CC1 354069 2-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(trans-4-hydroxycyclohexyl)acetamide::US9796708, Example 1301 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354069&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897351 386047801 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697438 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)c1cc(O)no1 InChI=1S/C23H19FN4O4/c1-31-19-3-2-14(24)10-16(19)15-4-7-25-22-17(15)11-18(26-22)13-5-8-28(9-6-13)23(30)20-12-21(29)27-32-20/h2-5,7,10-12H,6,8-9H2,1H3,(H,25,26)(H,27,29) HRVIIKUMYGZOHH-UHFFFAOYSA-N 354070 US9796708, Example 1302::{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}(3-hydroxy-1,2-oxazol-5-yl)methanone Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354070&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897225 386047802 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697439 CNC(=O)N1CC(C1)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1O InChI=1S/C23H24FN5O2/c1-25-23(31)29-12-16(13-29)28-8-5-14(6-9-28)20-11-19-17(4-7-26-22(19)27-20)18-10-15(24)2-3-21(18)30/h2-5,7,10-11,16,30H,6,8-9,12-13H2,1H3,(H,25,31)(H,26,27) QZHZGNZNDOKZBV-UHFFFAOYSA-N 354071 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-methylazetidine-1-carboxamide::US9796708, Example 1303 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354071&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139208181 386047803 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697440 CNC(=O)N1CC(C1)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C24H28FN5O2/c1-26-24(31)30-13-17(14-30)29-9-6-15(7-10-29)21-12-20-18(5-8-27-23(20)28-21)19-11-16(25)3-4-22(19)32-2/h3-5,8,11-12,15,17H,6-7,9-10,13-14H2,1-2H3,(H,26,31)(H,27,28) XIYMUVGINIAVEQ-UHFFFAOYSA-N 354072 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N-methylazetidine-1-carboxamide::US9796708, Example 1304 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354072&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421281 386047804 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697441 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC(C1)C#N InChI=1S/C24H23FN4O/c1-30-23-3-2-17(25)12-20(23)19-4-7-27-24-21(19)13-22(28-24)16-5-8-29(9-6-16)18-10-15(11-18)14-26/h2-5,7,12-13,15,18H,6,8-11H2,1H3,(H,27,28) QACPLPKGSYFDAN-UHFFFAOYSA-N 354073 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobutanecarbonitrile::US9796708, Example 1305 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354073&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421762 386047805 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697442 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CCC(C1)C(O)=O 354074 3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclopentanecarboxylic acid::US9796708, Example 1306 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354074&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897451 386047806 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697443 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC2(CCNCC2)CC1 InChI=1S/C24H26FN3O/c1-29-22-3-2-17(25)14-19(22)18-6-11-27-23-20(18)15-21(28-23)16-4-7-24(8-5-16)9-12-26-13-10-24/h2-4,6,11,14-15,26H,5,7-10,12-13H2,1H3,(H,27,28) CWAARJDFXAIYRN-UHFFFAOYSA-N 354075 9-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-azaspiro[5.5]undec-8-ene::US9796708, Example 1307 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 96.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354075&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420806 386047807 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697444 CNC(=O)N1CCC2(CC1)CCC(=CC2)c1cc2c(ccnc2[nH]1)-c1cc(F)ccc1OC InChI=1S/C26H29FN4O2/c1-28-25(32)31-13-10-26(11-14-31)8-5-17(6-9-26)22-16-21-19(7-12-29-24(21)30-22)20-15-18(27)3-4-23(20)33-2/h3-5,7,12,15-16H,6,8-11,13-14H2,1-2H3,(H,28,32)(H,29,30) WGMNWDUNQFMGMT-UHFFFAOYSA-N 354076 9-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-3-azaspiro[5.5]undec-8-ene-3-carboxamide::US9796708, Example 1308 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 440 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354076&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420414 386047808 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697445 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC2(CCN(CC2)S(C)(=O)=O)CC1 InChI=1S/C25H28FN3O3S/c1-32-23-4-3-18(26)15-20(23)19-7-12-27-24-21(19)16-22(28-24)17-5-8-25(9-6-17)10-13-29(14-11-25)33(2,30)31/h3-5,7,12,15-16H,6,8-11,13-14H2,1-2H3,(H,27,28) MDKYHGYMGJMIMK-UHFFFAOYSA-N 354077 9-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-(methylsulfonyl)-3-azaspiro[5.5]undec-8-ene::US9796708, Example 1309 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1310 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354077&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419653 386047809 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697446 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1CC(CO)C1 InChI=1S/C24H26FN3O2/c1-30-23-3-2-17(25)12-20(23)19-4-7-26-24-21(19)13-22(27-24)16-5-8-28(9-6-16)18-10-15(11-18)14-29/h2-5,7,12-13,15,18,29H,6,8-11,14H2,1H3,(H,26,27) LUPKSZPIZUWUNZ-UHFFFAOYSA-N 354078 (3-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclobutyl)methanol::US9796708, Example 1310 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354078&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420006 386047810 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697447 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1 354079 (trans-4-{4-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexyl)acetic acid::US9796708, Example 1311 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354079&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419712 386047811 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697448 COc1ccc(F)cc1-c1c(Cl)cnc2[nH]c(cc12)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1 354080 (cis-4-{4-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexyl)acetic acid::US9796708, Example 1312 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 77.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354080&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419712 386047812 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697449 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)NC2CCS(=O)(=O)C2)CC1 354081 N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}acetamide::US9796708, Example 1313 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354081&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897389 386047813 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697450 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)NC2CCS(=O)(=O)C2)CC1 354082 N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}acetamide::US9796708, Example 1314 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 140 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354082&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897265 386047814 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697451 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)N2CC(C2)S(C)(=O)=O)CC1 InChI=1S/C25H27FN4O4S/c1-34-23-4-3-17(26)11-20(23)19-5-8-27-25-21(19)12-22(28-25)16-6-9-29(10-7-16)15-24(31)30-13-18(14-30)35(2,32)33/h3-6,8,11-12,18H,7,9-10,13-15H2,1-2H3,(H,27,28) NXTWSCJTOSWKTL-UHFFFAOYSA-N 354083 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-1-[3-(methylsulfonyl)azetidin-1-yl]ethanone::US9796708, Example 1315 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354083&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897258 386047815 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697452 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CC(C2)S(C)(=O)=O)CC1 InChI=1S/C25H29FN4O4S/c1-34-23-4-3-17(26)11-20(23)19-5-8-27-25-21(19)12-22(28-25)16-6-9-29(10-7-16)15-24(31)30-13-18(14-30)35(2,32)33/h3-5,8,11-12,16,18H,6-7,9-10,13-15H2,1-2H3,(H,27,28) ZBMYGZFWQFXKOX-UHFFFAOYSA-N 354084 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-1-[3-(methylsulfonyl)azetidin-1-yl]ethanone::US9796708, Example 1316 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354084&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897383 386047816 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697453 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(=O)Nc2cnn(C)c2)CC1 InChI=1S/C25H25FN6O2/c1-31-14-18(13-28-31)29-24(33)15-32-9-6-16(7-10-32)22-12-21-19(5-8-27-25(21)30-22)20-11-17(26)3-4-23(20)34-2/h3-6,8,11-14H,7,9-10,15H2,1-2H3,(H,27,30)(H,29,33) ZXGXHLWAXZONOP-UHFFFAOYSA-N 354085 2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}-N-(1-methyl-1H-pyrazol-4-yl)acetamide::US9796708, Example 1317 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354085&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421002 386047817 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697454 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O 354086 4-(4-fluoro-2-methoxyphenyl)-2-[2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1318 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420155 386047818 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697455 COc1cc(F)c(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O 354087 4-(4,5-difluoro-2-methoxyphenyl)-2-[2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1319 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354087&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420123 386047819 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697456 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2CC(=O)N(C)CCO 354088 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}-N-(2-hydroxyethyl)-N-methylacetamide::US9796708, Example 1320 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 170 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354088&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419976 386047820 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697457 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2CC(=O)N1CC(O)C1 354089 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}-1-(3-hydroxyazetidin-1-yl)ethanone::US9796708, Example 1321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354089&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420383 386047821 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697458 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2CC(=O)N1CCC[C@H]1CO InChI=1S/C29H33FN4O3/c1-37-27-8-7-19(30)14-24(27)23-9-10-31-29-25(23)15-26(32-29)18-12-20-4-2-5-21(13-18)34(20)16-28(36)33-11-3-6-22(33)17-35/h7-10,12,14-15,20-22,35H,2-6,11,13,16-17H2,1H3,(H,31,32)/t20?,21?,22-/m0/s1 IBZGYUXCLXCPNB-HRTMPFAESA-N 354090 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanone::US9796708, Example 1322 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 120 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354090&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90419873 386047822 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697459 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2CC(=O)N(C)C1CC(O)C1 354091 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}-N-(3-hydroxycyclobutyl)-N-methylacetamide::US9796708, Example 1323 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354091&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90421176 386047823 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697460 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CC2CCCC(C1)N2CC(O)=O 354092 US9796708, Example 1324::{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-9-azabicyclo[3.3.1]non-2-en-9-yl}acetic acid Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354092&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118897428 386047824 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697461 COc1ccccc1-c1ccnc2[nH]c(cc12)C1=CC2CN(CC2C1)S(C)(=O)=O 354093 4-(2-methoxyphenyl)-2-[2-(methylsulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrol-5-yl]-1H-pyrrolo[2,3-b]pyridine::US9796708, Example 1325 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 130 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354093&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420147 386047825 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697462 COc1ccc(F)cc1-c1ccnc2[nH]c(N3CCNCC3)c(C#N)c12 InChI=1S/C19H18FN5O/c1-26-16-3-2-12(20)10-14(16)13-4-5-23-18-17(13)15(11-21)19(24-18)25-8-6-22-7-9-25/h2-5,10,22H,6-9H2,1H3,(H,23,24) OJGKMXWRDXJXJO-UHFFFAOYSA-N 354094 4-(5-fluoro-2-methoxyphenyl)-2-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile::US9796708, Example 1326 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354094&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90420422 386047826 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 697463 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CCNC(=O)OC(C)(C)C)CC1 InChI=1S/C26H31FN4O3/c1-26(2,3)34-25(32)29-11-14-31-12-8-17(9-13-31)22-16-21-19(7-10-28-24(21)30-22)20-15-18(27)5-6-23(20)33-4/h5-8,10,15-16H,9,11-14H2,1-4H3,(H,28,30)(H,29,32) KRVPHXOFBXQRDA-UHFFFAOYSA-N 354095 US9796708, Example 1327::tert-butyl (2-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}ethyl)carbamate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 US Patent 10.7270/Q2WD42P4 aid1797504 US9796708 Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB AbbVie Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354095&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 131746442 386047827 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761858 COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC InChI=1S/C25H21N5O2/c1-31-22-13-19-20(14-23(22)32-2)26-16-27-25(19)28-24-15-21(17-9-5-3-6-10-17)30(29-24)18-11-7-4-8-12-18/h3-16H,1-2H3,(H,26,27,28,29) RPCSWMNAMGPZSE-UHFFFAOYSA-N 50242622 CHEMBL4065204 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242622&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137632779 386402638 CHEMBL4065204 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761860 COc1cc2ncnc(Nc3cc([nH]n3)-c3ccc(Cl)cc3)c2cc1OC InChI=1S/C19H16ClN5O2/c1-26-16-7-13-15(8-17(16)27-2)21-10-22-19(13)23-18-9-14(24-25-18)11-3-5-12(20)6-4-11/h3-10H,1-2H3,(H2,21,22,23,24,25) XFVUOVJZXXGWDV-UHFFFAOYSA-N 50242618 CHEMBL4099804 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242618&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137659788 386402634 CHEMBL4099804 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761861 COc1cc2ncnc(Nc3cc([nH]n3)-c3ccc(F)cc3)c2cc1OC InChI=1S/C19H16FN5O2/c1-26-16-7-13-15(8-17(16)27-2)21-10-22-19(13)23-18-9-14(24-25-18)11-3-5-12(20)6-4-11/h3-10H,1-2H3,(H2,21,22,23,24,25) MBDHUNWSWSQSLU-UHFFFAOYSA-N 50242619 CHEMBL4105091 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242619&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137658447 386402635 CHEMBL4105091 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761864 COc1cc2ncnc(Nc3cc([nH]n3)-c3ccccc3)c2cc1OC InChI=1S/C19H17N5O2/c1-25-16-8-13-15(9-17(16)26-2)20-11-21-19(13)22-18-10-14(23-24-18)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,20,21,22,23,24) FSKWVQYXXLTRRM-UHFFFAOYSA-N 50242623 CHEMBL4080858 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242623&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 17942760 386402639 CHEMBL4080858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761866 COc1cc2ncnc(Nc3cc(O)[nH]n3)c2cc1OC InChI=1S/C13H13N5O3/c1-20-9-3-7-8(4-10(9)21-2)14-6-15-13(7)16-11-5-12(19)18-17-11/h3-6H,1-2H3,(H3,14,15,16,17,18,19) IDAIFIZBEJFFJM-UHFFFAOYSA-N 50242621 CHEMBL4070204 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242621&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137638906 386402637 CHEMBL4070204 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761921 COc1ccc(cc1)-c1cc(Nc2ncnc3cc(OC)c(OC)cc23)n[nH]1 InChI=1S/C20H19N5O3/c1-26-13-6-4-12(5-7-13)15-10-19(25-24-15)23-20-14-8-17(27-2)18(28-3)9-16(14)21-11-22-20/h4-11H,1-3H3,(H2,21,22,23,24,25) ZHRZUJDEOZWDOA-UHFFFAOYSA-N 50242624 CHEMBL4081787 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242624&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137647416 386402640 CHEMBL4081787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50761924 COc1cc2ncnc(Nc3n[nH]cc3C#N)c2cc1OC InChI=1S/C14H12N6O2/c1-21-11-3-9-10(4-12(11)22-2)16-7-17-14(9)19-13-8(5-15)6-18-20-13/h3-4,6-7H,1-2H3,(H2,16,17,18,19,20) OQUOJUDRDBAFJQ-UHFFFAOYSA-N 50242620 CHEMBL4097381 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2017.04.080 10.7270/Q28P62X6 28487075 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P Rajiv Gandhi Proudyogiki Vishwavidyalaya http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242620&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137659439 386402636 CHEMBL4097381 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50765742 CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc2n1C1CCCC1 InChI=1S/C28H37N7O4/c1-34(2)27(38)23-17-19-18-29-28(32-26(19)35(23)22-9-7-8-10-22)31-21-15-13-20(14-16-21)30-24(36)11-5-3-4-6-12-25(37)33-39/h13-18,22,39H,3-12H2,1-2H3,(H,30,36)(H,33,37)(H,29,31,32) JWILUIVAYLRFIY-UHFFFAOYSA-N 50244953 CHEMBL4063500 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9 ChEMBL 10.1021/acs.jmedchem.8b00209 10.7270/Q2KS6TZK 29518312 Li, Y; Luo, X; Guo, Q; Nie, Y; Wang, T; Zhang, C; Huang, Z; Wang, X; Liu, Y; Chen, Y; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50244953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50244953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137634634 386403283 CHEMBL4063500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774220 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CNCc1ccccc1 InChI=1S/C26H26N4O2/c1-31-24-13-12-21(14-20(24)17-27-16-19-8-4-3-5-9-19)30-26-15-23(28-18-29-26)22-10-6-7-11-25(22)32-2/h3-15,18,27H,16-17H2,1-2H3,(H,28,29,30) RRTZIOOYMHSXQU-UHFFFAOYSA-N 316172 N-(3-((benzylamino)methyl)-4-methoxyphenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 1::US9617225, Example 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316172&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334954 384219540 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774221 COc1ccccc1-c1cc(Nc2ccc(N3CCN(C)CC3)c(Cn3cnc4ccccc34)c2)ncn1 InChI=1S/C30H31N7O/c1-35-13-15-36(16-14-35)27-12-11-23(17-22(27)19-37-21-33-25-8-4-5-9-28(25)37)34-30-18-26(31-20-32-30)24-7-3-6-10-29(24)38-2/h3-12,17-18,20-21H,13-16,19H2,1-2H3,(H,31,32,34) MJHPGOGALOUSJW-UHFFFAOYSA-N 316174 N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-(4-methylpiperazin-1-yl)phenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 2::US9617225, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316174&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334865 384219542 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774222 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CN1C(=O)c2ccccc2C1=O InChI=1S/C27H22N4O4/c1-34-23-12-11-18(13-17(23)15-31-26(32)19-7-3-4-8-20(19)27(31)33)30-25-14-22(28-16-29-25)21-9-5-6-10-24(21)35-2/h3-14,16H,15H2,1-2H3,(H,28,29,30) RMMKDAOHCOETTH-UHFFFAOYSA-N 316175 2-(2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzyl)isoindoline-1,3-dione::US10294218, Example 3::US9617225, Example 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316175&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334952 384219543 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774223 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CNS(C)(=O)=O InChI=1S/C20H22N4O4S/c1-27-18-9-8-15(10-14(18)12-23-29(3,25)26)24-20-11-17(21-13-22-20)16-6-4-5-7-19(16)28-2/h4-11,13,23H,12H2,1-3H3,(H,21,22,24) MGZRNXBSXMBQDH-UHFFFAOYSA-N 316176 N-(2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzyl)methanesulfonamide::US10294218, Example 4::US9617225, Example 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316176&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334953 384219544 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774224 COc1ccccc1-c1cc(Nc2ccc(cc2)N(C)C)ncn1 InChI=1S/C19H20N4O/c1-23(2)15-10-8-14(9-11-15)22-19-12-17(20-13-21-19)16-6-4-5-7-18(16)24-3/h4-13H,1-3H3,(H,20,21,22) KYYPNZMKGBZDPZ-UHFFFAOYSA-N 316177 N1-(6-(2-methoxyphenyl)pyrimidin-4-yl)- N4,N4-dimethylbenzene-1,4-diamine::US10294218, Example 5::US9617225, Example 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316177&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979277 384219545 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774225 COc1ccccc1-c1cc(Nc2ccc(Cl)c(CO)c2)ncn1 InChI=1S/C18H16ClN3O2/c1-24-17-5-3-2-4-14(17)16-9-18(21-11-20-16)22-13-6-7-15(19)12(8-13)10-23/h2-9,11,23H,10H2,1H3,(H,20,21,22) WNTHDIHGEKWCDH-UHFFFAOYSA-N 316178 (2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanol::US10294218, Example 6::US9617225, Example 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316178&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978952 384219546 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774226 COc1ccccc1-c1cc(Nc2ccc(Cl)c(c2)C(=O)NN)ncn1 InChI=1S/C18H16ClN5O2/c1-26-16-5-3-2-4-12(16)15-9-17(22-10-21-15)23-11-6-7-14(19)13(8-11)18(25)24-20/h2-10H,20H2,1H3,(H,24,25)(H,21,22,23) RLWDIRSBBGDYPH-UHFFFAOYSA-N 316179 2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzohydrazide::US10294218, Example 7::US9617225, Example 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316179&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979231 384219547 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774227 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OCCN1CCOCC1 InChI=1S/C24H28N4O4/c1-29-21-6-4-3-5-19(21)20-16-24(26-17-25-20)27-18-7-8-22(30-2)23(15-18)32-14-11-28-9-12-31-13-10-28/h3-8,15-17H,9-14H2,1-2H3,(H,25,26,27) LQFMWBKCHKKJHN-UHFFFAOYSA-N 316180 N-(4-methoxy-3-(2-morpholinoethoxy)phenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 8::US9617225, Example 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316180&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979066 384219548 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774228 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NS(C)(=O)=O InChI=1S/C19H20N4O4S/c1-26-17-7-5-4-6-14(17)15-11-19(21-12-20-15)22-13-8-9-18(27-2)16(10-13)23-28(3,24)25/h4-12,23H,1-3H3,(H,20,21,22) IFZPXOBIPGZTNZ-UHFFFAOYSA-N 316181 N-(2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide::US10294218, Example 9::US9617225, Example 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316181&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978965 384219549 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774229 CNS(=O)(=O)Nc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C19H21N5O4S/c1-20-29(25,26)24-16-10-13(8-9-18(16)28-3)23-19-11-15(21-12-22-19)14-6-4-5-7-17(14)27-2/h4-12,20,24H,1-3H3,(H,21,22,23) IUROKBZVNUPFOD-UHFFFAOYSA-N 316182 (2-methoxy-5-(6-(2-methoxyphenyl) pyrimidin-4-ylamino)phenyl) (methylsulfamoyl)amine::US10294218, Example 10::US9617225, Example 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316182&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979178 384219550 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774230 COc1ccccc1-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C18H16N4O4/c1-25-16-6-4-3-5-13(16)14-10-18(20-11-19-14)21-12-7-8-17(26-2)15(9-12)22(23)24/h3-11H,1-2H3,(H,19,20,21) ZHFNQFDJLZJRPE-UHFFFAOYSA-N 316183 N-(4-methoxy-3-nitrophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 11::US9617225, Example 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979282 384219551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774231 COc1ccccc1-c1cc(Nc2ccc(O)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C17H14N4O4/c1-25-16-5-3-2-4-12(16)13-9-17(19-10-18-13)20-11-6-7-15(22)14(8-11)21(23)24/h2-10,22H,1H3,(H,18,19,20) DMDBRGXBQUMBAY-UHFFFAOYSA-N 316184 4-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-nitrophenol::US10294218, Example 12::US9617225, Example 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316184&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979473 384219552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774232 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NS(=O)(=O)NC1CCCCC1 InChI=1S/C24H29N5O4S/c1-32-22-11-7-6-10-19(22)20-15-24(26-16-25-20)27-18-12-13-23(33-2)21(14-18)29-34(30,31)28-17-8-4-3-5-9-17/h6-7,10-17,28-29H,3-5,8-9H2,1-2H3,(H,25,26,27) PVJFFYLYUJMIST-UHFFFAOYSA-N 316185 (2-methoxy-5-(6-(2-methoxyphenyl) pyrimidin-4-ylamino)phenyl) (cyclohexylsulfamoyl)amine::US10294218, Example 13::US9617225, Example 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316185&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983719 384219553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774233 CCOC(=O)c1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1Cl InChI=1S/C20H18ClN3O3/c1-3-27-20(25)15-10-13(8-9-16(15)21)24-19-11-17(22-12-23-19)14-6-4-5-7-18(14)26-2/h4-12H,3H2,1-2H3,(H,22,23,24) HDNWCYJPCOKYJM-UHFFFAOYSA-N 316186 US10294218, Example 14::US9617225, Example 14::ethyl 2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316186&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978967 384219554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774234 COc1ccccc1-c1cc(Nc2ccc(Cl)c(c2)C(=O)N2CCCC2)ncn1 InChI=1S/C22H21ClN4O2/c1-29-20-7-3-2-6-16(20)19-13-21(25-14-24-19)26-15-8-9-18(23)17(12-15)22(28)27-10-4-5-11-27/h2-3,6-9,12-14H,4-5,10-11H2,1H3,(H,24,25,26) ULARXAWBPFORAO-UHFFFAOYSA-N 316187 (2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone::US10294218, Example 15::US9617225, Example 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316187&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978947 384219555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774235 COc1ccccc1-c1cc(Nc2ccc(Cl)c(Cn3cnc4ccccc34)c2)ncn1 InChI=1S/C25H20ClN5O/c1-32-24-9-5-2-6-19(24)22-13-25(28-15-27-22)30-18-10-11-20(26)17(12-18)14-31-16-29-21-7-3-4-8-23(21)31/h2-13,15-16H,14H2,1H3,(H,27,28,30) XCQVRCQTAOBCGB-UHFFFAOYSA-N 316188 N-(3-((1H-benzo[d]imidazol-1- yl)methyl)-4-chlorophenyl)-6-(2- methoxyphenyl)pyrimidin-4-amine::US10294218, Example 16::US9617225, Example 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316188&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978814 384219556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774236 COc1ccccc1-c1cc(Nc2ccc(N3CCN(C)CC3)c(CO)c2)ncn1 InChI=1S/C23H27N5O2/c1-27-9-11-28(12-10-27)21-8-7-18(13-17(21)15-29)26-23-14-20(24-16-25-23)19-5-3-4-6-22(19)30-2/h3-8,13-14,16,29H,9-12,15H2,1-2H3,(H,24,25,26) VFFAMKASGMKJME-UHFFFAOYSA-N 316189 (5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol::US10294218, Example 17::US9617225, Example 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316189&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979241 384219557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774237 CCOC(=O)c1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1N1CCOCC1 InChI=1S/C24H26N4O4/c1-3-32-24(29)19-14-17(8-9-21(19)28-10-12-31-13-11-28)27-23-15-20(25-16-26-23)18-6-4-5-7-22(18)30-2/h4-9,14-16H,3,10-13H2,1-2H3,(H,25,26,27) NBYFNIACCOBTLD-UHFFFAOYSA-N 316190 US10294218, Example 18::US9617225, Example 18::ethyl 5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-morpholinobenzoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316190&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979137 384219558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774238 COc1ccccc1-c1cc(Nc2ccc(N3CCOCC3)c(CO)c2)ncn1 InChI=1S/C22H24N4O3/c1-28-21-5-3-2-4-18(21)19-13-22(24-15-23-19)25-17-6-7-20(16(12-17)14-27)26-8-10-29-11-9-26/h2-7,12-13,15,27H,8-11,14H2,1H3,(H,23,24,25) IJNQPWVZGIBNSB-UHFFFAOYSA-N 316191 (5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-morpholinophenyl)methanol::US10294218, Example 19::US9617225, Example 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316191&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979048 384219559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774239 COc1ccccc1-c1cc(Nc2ccc(Cl)c(CN3C(=O)c4ccccc4C3=O)c2)ncn1 InChI=1S/C26H19ClN4O3/c1-34-23-9-5-4-8-20(23)22-13-24(29-15-28-22)30-17-10-11-21(27)16(12-17)14-31-25(32)18-6-2-3-7-19(18)26(31)33/h2-13,15H,14H2,1H3,(H,28,29,30) LZHZGCLQGRXHHV-UHFFFAOYSA-N 316192 2-(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzyl)isoindoline-1,3-dione::US10294218, Example 20::US9617225, Example 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316192&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978932 384219560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774240 COC(=O)c1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1O InChI=1S/C19H17N3O4/c1-25-17-6-4-3-5-13(17)15-10-18(21-11-20-15)22-12-7-8-16(23)14(9-12)19(24)26-2/h3-11,23H,1-2H3,(H,20,21,22) MGJXIKGWPXNMEB-UHFFFAOYSA-N 316193 US10294218, Example 21::US9617225, Example 21::methyl 2-hydroxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316193&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979407 384219561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774241 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1F InChI=1S/C18H16FN3O2/c1-23-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-17(24-2)14(19)9-12/h3-11H,1-2H3,(H,20,21,22) QZIULHJPRUECDI-UHFFFAOYSA-N 316194 N-(3-fluoro-4-methoxyphenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 22::US9617225, Example 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316194&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979373 384219562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774242 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)NCc1ccccc1 InChI=1S/C26H24N4O3/c1-32-23-11-7-6-10-20(23)22-15-25(29-17-28-22)30-19-12-13-24(33-2)21(14-19)26(31)27-16-18-8-4-3-5-9-18/h3-15,17H,16H2,1-2H3,(H,27,31)(H,28,29,30) HTUJUPSQWAWCAZ-UHFFFAOYSA-N 316195 N-benzyl-2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzamide::US10294218, Example 23::US9617225, Example 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316195&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979094 384219563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774243 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CO InChI=1S/C19H19N3O3/c1-24-17-8-7-14(9-13(17)11-23)22-19-10-16(20-12-21-19)15-5-3-4-6-18(15)25-2/h3-10,12,23H,11H2,1-2H3,(H,20,21,22) MTXAAMINIIKRFL-UHFFFAOYSA-N 316196 (2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanol::US10294218, Example 24::US9617225, Example 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316196&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979361 384219564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774244 CNC(=O)c1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C20H20N4O3/c1-21-20(25)15-10-13(8-9-18(15)27-3)24-19-11-16(22-12-23-19)14-6-4-5-7-17(14)26-2/h4-12H,1-3H3,(H,21,25)(H,22,23,24) AMXBMUYVSHGDTR-UHFFFAOYSA-N 316197 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-methylbenzamide::US10294218, Example 25::US9617225, Example 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316197&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978896 384219565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774245 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC(=O)C(C)(C)C InChI=1S/C23H25N3O4/c1-23(2,3)22(27)30-20-12-15(10-11-19(20)29-5)26-21-13-17(24-14-25-21)16-8-6-7-9-18(16)28-4/h6-14H,1-5H3,(H,24,25,26) JRUORZLMWWONNF-UHFFFAOYSA-N 316198 2-methoxy-5-(6-(2- methoxyphenyl)pyrimidin-4- ylamino)phenyl pivalate::US10294218, Example 26::US9617225, Example 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316198&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979060 384219566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774246 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NC(=O)OCC(Cl)(Cl)Cl InChI=1S/C21H19Cl3N4O4/c1-30-17-6-4-3-5-14(17)15-10-19(26-12-25-15)27-13-7-8-18(31-2)16(9-13)28-20(29)32-11-21(22,23)24/h3-10,12H,11H2,1-2H3,(H,28,29)(H,25,26,27) XMUGFAWUVMZZNX-UHFFFAOYSA-N 316199 2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate::US10294218, Example 27::US9617225, Example 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316199&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979018 384219567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774247 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)NCc1ccncc1 InChI=1S/C25H23N5O3/c1-32-22-6-4-3-5-19(22)21-14-24(29-16-28-21)30-18-7-8-23(33-2)20(13-18)25(31)27-15-17-9-11-26-12-10-17/h3-14,16H,15H2,1-2H3,(H,27,31)(H,28,29,30) UYRFCYGCGKDURE-UHFFFAOYSA-N 316200 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide::US10294218, Example 28::US9617225, Example 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316200&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979246 384219568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774248 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C=O InChI=1S/C19H17N3O3/c1-24-17-8-7-14(9-13(17)11-23)22-19-10-16(20-12-21-19)15-5-3-4-6-18(15)25-2/h3-12H,1-2H3,(H,20,21,22) PGTQNQROLBSKPV-UHFFFAOYSA-N 316201 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzaldehyde::US10294218, Example 29::US9617225, Example 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316201&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979044 384219569 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774249 COC(=O)c1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C20H19N3O4/c1-25-17-7-5-4-6-14(17)16-11-19(22-12-21-16)23-13-8-9-18(26-2)15(10-13)20(24)27-3/h4-12H,1-3H3,(H,21,22,23) PHVDKJJVEABWIR-UHFFFAOYSA-N 316202 US10294218, Example 30::US9617225, Example 30::methyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzoate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316202&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978996 384219570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774250 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1Cn1cnc2ccccc12 InChI=1S/C26H23N5O2/c1-32-24-12-11-19(13-18(24)15-31-17-29-21-8-4-5-9-23(21)31)30-26-14-22(27-16-28-26)20-7-3-6-10-25(20)33-2/h3-14,16-17H,15H2,1-2H3,(H,27,28,30) JDTARNOSHIWZJR-UHFFFAOYSA-N 316203 N-(3-((1H-benzo[d]imidazol-1- yl)methyl)-4-methoxyphenyl)-6-(2- methoxyphenyl)pyrimidin-4-amine::US10294218, Example 31::US9617225, Example 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316203&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978893 384219571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774251 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1O InChI=1S/C18H17N3O3/c1-23-16-6-4-3-5-13(16)14-10-18(20-11-19-14)21-12-7-8-17(24-2)15(22)9-12/h3-11,22H,1-2H3,(H,19,20,21) ODUGNLJQVHXHDO-UHFFFAOYSA-N 316204 2-methoxy-5-(6-(2- methoxyphenyl)pyrimidin-4- ylamino)phenol::US10294218, Example 32::US9617225, Example 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316204&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334864 384219572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774252 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)NN InChI=1S/C19H19N5O3/c1-26-16-6-4-3-5-13(16)15-10-18(22-11-21-15)23-12-7-8-17(27-2)14(9-12)19(25)24-20/h3-11H,20H2,1-2H3,(H,24,25)(H,21,22,23) NGNNSZZIVJZTLW-UHFFFAOYSA-N 316205 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzohydrazide::US10294218, Example 33::US9617225, Example 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316205&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979309 384219573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774253 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CNc1ccccc1 InChI=1S/C25H24N4O2/c1-30-23-13-12-20(14-18(23)16-26-19-8-4-3-5-9-19)29-25-15-22(27-17-28-25)21-10-6-7-11-24(21)31-2/h3-15,17,26H,16H2,1-2H3,(H,27,28,29) OZDSGBMULZEOMK-UHFFFAOYSA-N 316206 N-(4-methoxy-3-((phenylamino)methyl)phenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 34::US9617225, Example 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316206&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979010 384219574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774254 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CN(C)C InChI=1S/C21H24N4O2/c1-25(2)13-15-11-16(9-10-19(15)26-3)24-21-12-18(22-14-23-21)17-7-5-6-8-20(17)27-4/h5-12,14H,13H2,1-4H3,(H,22,23,24) MQMKWVXZZLZFSN-UHFFFAOYSA-N 316207 N-(3-((dimethylamino)methyl)-4-methoxyphenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 35::US9617225, Example 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316207&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978936 384219575 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774255 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OCc1ccccc1 InChI=1S/C25H23N3O3/c1-29-22-11-7-6-10-20(22)21-15-25(27-17-26-21)28-19-12-13-23(30-2)24(14-19)31-16-18-8-4-3-5-9-18/h3-15,17H,16H2,1-2H3,(H,26,27,28) UAPBPOHZYCCAHI-UHFFFAOYSA-N 316208 N-(3-(benzyloxy)-4-methoxyphenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 36::US9617225, Example 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316208&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979038 384219576 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774256 CNCc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C20H22N4O2/c1-21-12-14-10-15(8-9-18(14)25-2)24-20-11-17(22-13-23-20)16-6-4-5-7-19(16)26-3/h4-11,13,21H,12H2,1-3H3,(H,22,23,24) SBXBMEMJHACJFD-UHFFFAOYSA-N 316209 N-(4-methoxy-3-((methylamino)methyl)phenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 37::US9617225, Example 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316209&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978921 384219577 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774257 COc1ccccc1-c1cc(Nc2ccc(N3CCN(C)CC3)c(c2)S(N)(=O)=O)ncn1 InChI=1S/C22H26N6O3S/c1-27-9-11-28(12-10-27)19-8-7-16(13-21(19)32(23,29)30)26-22-14-18(24-15-25-22)17-5-3-4-6-20(17)31-2/h3-8,13-15H,9-12H2,1-2H3,(H2,23,29,30)(H,24,25,26) BVIPBFLBEVHPIW-UHFFFAOYSA-N 316210 5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)benzenesulfonamide::US10294218, Example 38::US9617225, Example 38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979170 384219578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774258 CCOc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1Cn1cnc2ccccc12 InChI=1S/C27H25N5O2/c1-3-34-25-13-12-20(14-19(25)16-32-18-30-22-9-5-6-10-24(22)32)31-27-15-23(28-17-29-27)21-8-4-7-11-26(21)33-2/h4-15,17-18H,3,16H2,1-2H3,(H,28,29,31) JWXKFKUHLAQGQX-UHFFFAOYSA-N 316211 N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-ethoxyphenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 39::US9617225, Example 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316211&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979114 384219579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774259 COc1ccccc1-c1cc(Nc2ccc(F)c(Cn3cnc4ccccc34)c2)ncn1 InChI=1S/C25H20FN5O/c1-32-24-9-5-2-6-19(24)22-13-25(28-15-27-22)30-18-10-11-20(26)17(12-18)14-31-16-29-21-7-3-4-8-23(21)31/h2-13,15-16H,14H2,1H3,(H,27,28,30) PQJBTXIVTOSGTC-UHFFFAOYSA-N 316212 N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-fluorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 40::US9617225, Example 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979096 384219580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774260 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1N InChI=1S/C18H18N4O2/c1-23-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-17(24-2)14(19)9-12/h3-11H,19H2,1-2H3,(H,20,21,22) TXPMOQPTAHSPBJ-UHFFFAOYSA-N 316213 4-methoxy-N1-(6-(2- methoxyphenyl)pyrimidin-4-yl) benzene-1,3-diamine::US10294218, Example 41::US9617225, Example 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316213&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978782 384219581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774261 COc1ccccc1-c1cc(Nc2ccc(N(C)C)c(Cn3cnc4ccccc34)c2)ncn1 InChI=1S/C27H26N6O/c1-32(2)24-13-12-20(14-19(24)16-33-18-30-22-9-5-6-10-25(22)33)31-27-15-23(28-17-29-27)21-8-4-7-11-26(21)34-3/h4-15,17-18H,16H2,1-3H3,(H,28,29,31) TVLKGSNODYWKDT-UHFFFAOYSA-N 316214 2-((1H-benzo[d]imidazol-1-yl(methyl)-N4-(6-(2-methoxyphenyl)pyrimidin-4-yl)-N1,N1-dimethylbenzene-1,4-diamine::US10294218, Example 42::US9617225, Example 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316214&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979411 384219582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774262 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CN InChI=1S/C19H20N4O2/c1-24-17-8-7-14(9-13(17)11-20)23-19-10-16(21-12-22-19)15-5-3-4-6-18(15)25-2/h3-10,12H,11,20H2,1-2H3,(H,21,22,23) JIAIGGXLKACTDG-UHFFFAOYSA-N 316215 N-(3-(aminomethyl)-4- methoxyphenyl)-6-(2- methoxyphenyl)pyrimidin- 4-amine::US10294218, Example 43::US9617225, Example 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316215&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979320 384219583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774263 COc1ccccc1-c1cc(Nc2ccc(Cl)c(c2)C(N)=O)ncn1 InChI=1S/C18H15ClN4O2/c1-25-16-5-3-2-4-12(16)15-9-17(22-10-21-15)23-11-6-7-14(19)13(8-11)18(20)24/h2-10H,1H3,(H2,20,24)(H,21,22,23) RTVUOCUVPWTOLB-UHFFFAOYSA-N 316216 2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzamide::US10294218, Example 44::US9617225, Example 44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316216&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978890 384219584 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774264 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(N)=O InChI=1S/C19H18N4O3/c1-25-16-6-4-3-5-13(16)15-10-18(22-11-21-15)23-12-7-8-17(26-2)14(9-12)19(20)24/h3-11H,1-2H3,(H2,20,24)(H,21,22,23) ZEMCPOSFLUAYMK-UHFFFAOYSA-N 316217 2-methoxy-5-(6-(2- methoxyphenyl)pyrimidin-4- ylamino)benzamide::US10294218, Example 45::US9617225, Example 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979730 384219585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774265 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)N(C)N InChI=1S/C20H21N5O3/c1-25(21)20(26)15-10-13(8-9-18(15)28-3)24-19-11-16(22-12-23-19)14-6-4-5-7-17(14)27-2/h4-12H,21H2,1-3H3,(H,22,23,24) PKXGORXSUSYYLX-UHFFFAOYSA-N 316218 2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid N-methyl-hydrazide::US10294218, Example 46::US9617225, Example 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316218&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979515 384219586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774266 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)NCCCN1CCN(C)CC1 InChI=1S/C27H34N6O3/c1-32-13-15-33(16-14-32)12-6-11-28-27(34)22-17-20(9-10-25(22)36-3)31-26-18-23(29-19-30-26)21-7-4-5-8-24(21)35-2/h4-5,7-10,17-19H,6,11-16H2,1-3H3,(H,28,34)(H,29,30,31) JCSLVOIYIMRUMF-UHFFFAOYSA-N 316219 2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-N-[3-(4-methyl-piperazin-1-yl)-propyl]-benzamide::US10294218, Example 47::US9617225, Example 47 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316219&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979030 384219587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774267 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)NCCO InChI=1S/C21H22N4O4/c1-28-18-6-4-3-5-15(18)17-12-20(24-13-23-17)25-14-7-8-19(29-2)16(11-14)21(27)22-9-10-26/h3-8,11-13,26H,9-10H2,1-2H3,(H,22,27)(H,23,24,25) HOKMOPGKKOUHRL-UHFFFAOYSA-N 316220 N-(2-Hydroxy-ethyl)-2-methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 48::US9617225, Example 48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316220&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334955 384219588 C04080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774268 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(O)=O InChI=1S/C19H17N3O4/c1-25-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-17(26-2)14(9-12)19(23)24/h3-11H,1-2H3,(H,23,24)(H,20,21,22) AONWAAATMIVVNJ-UHFFFAOYSA-N 316221 2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid::US10294218, Example 49::US9617225, Example 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316221&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334956 384219589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774269 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NC(C)=O InChI=1S/C20H20N4O3/c1-13(25)23-17-10-14(8-9-19(17)27-3)24-20-11-16(21-12-22-20)15-6-4-5-7-18(15)26-2/h4-12H,1-3H3,(H,23,25)(H,21,22,24) UEYKOWLQQSJOFF-UHFFFAOYSA-N 316222 N-{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-acetamide::US10294218, Example 50::US9617225, Example 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316222&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979595 384219590 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774270 COC(=O)Nc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C20H20N4O4/c1-26-17-7-5-4-6-14(17)15-11-19(22-12-21-15)23-13-8-9-18(27-2)16(10-13)24-20(25)28-3/h4-12H,1-3H3,(H,24,25)(H,21,22,23) QDNGLPKWBCKXCQ-UHFFFAOYSA-N 316223 US10294218, Example 51::US9617225, Example 51::{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-carbamic acid methyl ester Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316223&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334957 384219591 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774271 CNC(=O)Nc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C20H21N5O3/c1-21-20(26)25-16-10-13(8-9-18(16)28-3)24-19-11-15(22-12-23-19)14-6-4-5-7-17(14)27-2/h4-12H,1-3H3,(H2,21,25,26)(H,22,23,24) AGWUPNXFWZRYDB-UHFFFAOYSA-N 316224 1-{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-3-methyl-urea::US10294218, Example 52::US9617225, Example 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316224&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335045 384219592 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774272 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NC(=O)C(C)(C)C InChI=1S/C23H26N4O3/c1-23(2,3)22(28)27-18-12-15(10-11-20(18)30-5)26-21-13-17(24-14-25-21)16-8-6-7-9-19(16)29-4/h6-14H,1-5H3,(H,27,28)(H,24,25,26) VIURZHLUCZXIHD-UHFFFAOYSA-N 316225 N-{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-2,2-dimethyl-propionamide::US10294218, Example 53::US9617225, Example 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316225&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335046 384219593 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774273 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1Nc1nc2ccccc2[nH]1 InChI=1S/C25H22N6O2/c1-32-22-10-6-3-7-17(22)20-14-24(27-15-26-20)28-16-11-12-23(33-2)21(13-16)31-25-29-18-8-4-5-9-19(18)30-25/h3-15H,1-2H3,(H,26,27,28)(H2,29,30,31) NVAHKHBBFVBFTR-UHFFFAOYSA-N 316226 N3-(1H-Benzoimidazol-2-yl)-4-methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 54::US9617225, Example 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316226&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335047 384219594 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774274 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NC=O InChI=1S/C19H18N4O3/c1-25-17-6-4-3-5-14(17)15-10-19(21-11-20-15)23-13-7-8-18(26-2)16(9-13)22-12-24/h3-12H,1-2H3,(H,22,24)(H,20,21,23) BSCGNPAXUDWCSA-UHFFFAOYSA-N 316227 N-{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-formamide::US10294218, Example 55::US9617225, Example 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316227&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979033 384219595 C06049 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774275 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1NC(N)=O InChI=1S/C19H19N5O3/c1-26-16-6-4-3-5-13(16)14-10-18(22-11-21-14)23-12-7-8-17(27-2)15(9-12)24-19(20)25/h3-11H,1-2H3,(H3,20,24,25)(H,21,22,23) BXVUBJVCVJBMGK-UHFFFAOYSA-N 316228 US10294218, Example 56::US9617225, Example 56::{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-urea Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316228&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335048 384219596 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774276 COc1ccccc1-c1cc(Nc2ccc(c(F)c2)[N+]([O-])=O)ncn1 InChI=1S/C17H13FN4O3/c1-25-16-5-3-2-4-12(16)14-9-17(20-10-19-14)21-11-6-7-15(22(23)24)13(18)8-11/h2-10H,1H3,(H,19,20,21) NGBHCPBYCZJVND-UHFFFAOYSA-N 316229 (3-Fluoro-4-nitro-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 57::US9617225, Example 57 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316229&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335049 384219597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774277 COc1ccccc1-c1cc(Nc2ccc(c(OC)c2)[N+]([O-])=O)ncn1 InChI=1S/C18H16N4O4/c1-25-16-6-4-3-5-13(16)14-10-18(20-11-19-14)21-12-7-8-15(22(23)24)17(9-12)26-2/h3-11H,1-2H3,(H,19,20,21) HJIQUSMKNTUPPG-UHFFFAOYSA-N 316230 (3-Methoxy-4-nitro-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 58::US9617225, Example 58 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316230&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978987 384219598 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774278 COc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1N InChI=1S/C18H18N4O2/c1-23-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-14(19)17(9-12)24-2/h3-11H,19H2,1-2H3,(H,20,21,22) HGSMVNIIHBGJNM-UHFFFAOYSA-N 316231 2-Methoxy-N4-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,4-diamine::US10294218, Example 59::US9617225, Example 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316231&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979723 384219599 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774279 COc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1NS(C)(=O)=O InChI=1S/C19H20N4O4S/c1-26-17-7-5-4-6-14(17)16-11-19(21-12-20-16)22-13-8-9-15(18(10-13)27-2)23-28(3,24)25/h4-12,23H,1-3H3,(H,20,21,22) DBOJYABMZWDTGE-UHFFFAOYSA-N 316232 N-{2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide::US10294218, Example 60::US9617225, Example 60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316232&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335050 384219600 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774280 CCOc1ccccc1-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C19H18N4O4/c1-3-27-17-7-5-4-6-14(17)15-11-19(21-12-20-15)22-13-8-9-18(26-2)16(10-13)23(24)25/h4-12H,3H2,1-2H3,(H,20,21,22) MDHRKWGOQPCJOA-UHFFFAOYSA-N 316233 US10294218, Example 61::US9617225, Example 61::[6-(2-Ethoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316233&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979179 384219601 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774281 CCOc1ccccc1-c1cc(Nc2ccc(OC)c(N)c2)ncn1 InChI=1S/C19H20N4O2/c1-3-25-17-7-5-4-6-14(17)16-11-19(22-12-21-16)23-13-8-9-18(24-2)15(20)10-13/h4-12H,3,20H2,1-2H3,(H,21,22,23) DYZODFAXTHBDQE-UHFFFAOYSA-N 316234 N1-[6-(2-Ethoxy-phenyl)-pyrimidin- 4-yl]-4-methoxy-benzene- 1,3-diamine::US10294218, Example 62::US9617225, Example 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316234&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89981828 384219602 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774282 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1[N+]([O-])=O InChI=1S/C18H15FN4O4/c1-26-16-6-4-12(8-15(16)23(24)25)22-18-9-14(20-10-21-18)13-5-3-11(19)7-17(13)27-2/h3-10H,1-2H3,(H,20,21,22) BJAFJDPQKMCVGG-UHFFFAOYSA-N 316235 US10294218, Example 63::US9617225, Example 63::[6-(4-Fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316235&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979797 384219603 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774283 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1N InChI=1S/C18H17FN4O2/c1-24-16-6-4-12(8-14(16)20)23-18-9-15(21-10-22-18)13-5-3-11(19)7-17(13)25-2/h3-10H,20H2,1-2H3,(H,21,22,23) BVQPMFIOQAQREE-UHFFFAOYSA-N 316236 N1-[6-(4-Fluoro-2-methoxy-phenyl)- pyrimidin-4-yl]-4-methoxy-benzene- 1,3-diamine::US10294218, Example 64::US9617225, Example 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316236&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89981829 384219604 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774284 COc1ccc(cc1)-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C18H16N4O4/c1-25-14-6-3-12(4-7-14)15-10-18(20-11-19-15)21-13-5-8-17(26-2)16(9-13)22(23)24/h3-11H,1-2H3,(H,19,20,21) ZMFVIJUBHZVNCX-UHFFFAOYSA-N 316237 (4-Methoxy-3-nitro-phenyl)-[6-(4-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 65::US9617225, Example 65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316237&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978949 384219605 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774285 COc1ccc(cc1)-c1cc(Nc2ccc(OC)c(N)c2)ncn1 InChI=1S/C18H18N4O2/c1-23-14-6-3-12(4-7-14)16-10-18(21-11-20-16)22-13-5-8-17(24-2)15(19)9-13/h3-11H,19H2,1-2H3,(H,20,21,22) QSXUHCNTCYKLBV-UHFFFAOYSA-N 316238 4-Methoxy-N1-[6-(4-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 66::US9617225, Example 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316238&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979210 384219606 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774286 COc1cccc(c1)-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C18H16N4O4/c1-25-14-5-3-4-12(8-14)15-10-18(20-11-19-15)21-13-6-7-17(26-2)16(9-13)22(23)24/h3-11H,1-2H3,(H,19,20,21) ZFEDKPDRUFHYSI-UHFFFAOYSA-N 316239 (4-Methoxy-3-nitro-phenyl)-[6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 67::US9617225, Example 67 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316239&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979494 384219607 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774287 COc1cccc(c1)-c1cc(Nc2ccc(OC)c(N)c2)ncn1 InChI=1S/C18H18N4O2/c1-23-14-5-3-4-12(8-14)16-10-18(21-11-20-16)22-13-6-7-17(24-2)15(19)9-13/h3-11H,19H2,1-2H3,(H,20,21,22) HCJQEGQYJAPOPZ-UHFFFAOYSA-N 316240 4-Methoxy-N1-[6-(3-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 68::US9617225, Example 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316240&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979480 384219608 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774288 COc1ccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)cc1[N+]([O-])=O InChI=1S/C24H20N4O4/c1-31-23-12-11-18(13-21(23)28(29)30)27-24-14-20(25-16-26-24)19-9-5-6-10-22(19)32-15-17-7-3-2-4-8-17/h2-14,16H,15H2,1H3,(H,25,26,27) NPRDZNZLCPSEQD-UHFFFAOYSA-N 316241 US10294218, Example 69::US9617225, Example 69::[6-(2-Benzyloxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316241&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335143 384219609 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774289 COc1ccc(Nc2cc(ncn2)-c2ccccc2O)cc1N InChI=1S/C17H16N4O2/c1-23-16-7-6-11(8-13(16)18)21-17-9-14(19-10-20-17)12-4-2-3-5-15(12)22/h2-10,22H,18H2,1H3,(H,19,20,21) VTMTXQHJCARMSY-UHFFFAOYSA-N 316242 2-[6-(3-Amino-4-methoxy-phenylamino)-pyrimidin-4-yl]-phenol::US10294218, Example 70::US9617225, Example 70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316242&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136633866 384219610 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774290 COc1ccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)cc1N InChI=1S/C24H22N4O2/c1-29-23-12-11-18(13-20(23)25)28-24-14-21(26-16-27-24)19-9-5-6-10-22(19)30-15-17-7-3-2-4-8-17/h2-14,16H,15,25H2,1H3,(H,26,27,28) IJINHMPKIAUEJD-UHFFFAOYSA-N 316243 N1-[6-(2-Benzyloxy-phenyl)-pyrimidin-4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 71::US9617225, Example 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316243&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983756 384219611 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774291 CCOc1cc(F)ccc1-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C19H17FN4O4/c1-3-28-18-8-12(20)4-6-14(18)15-10-19(22-11-21-15)23-13-5-7-17(27-2)16(9-13)24(25)26/h4-11H,3H2,1-2H3,(H,21,22,23) UBBNIMVUKDIYHF-UHFFFAOYSA-N 316244 US10294218, Example 72::US9617225, Example 72::[6-(2-Ethoxy-4-fluoro-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316244&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335144 384219612 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774292 CCOc1cc(F)ccc1-c1cc(Nc2ccc(OC)c(N)c2)ncn1 InChI=1S/C19H19FN4O2/c1-3-26-18-8-12(20)4-6-14(18)16-10-19(23-11-22-16)24-13-5-7-17(25-2)15(21)9-13/h4-11H,3,21H2,1-2H3,(H,22,23,24) KJWVNRGEKKXGAH-UHFFFAOYSA-N 316245 N1-[6-(2-Ethoxy-4-fluoro-phenyl)- pyrimidin-4-yl]-4-methoxy-benzene- 1,3-diamine::US10294218, Example 73::US9617225, Example 73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316245&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73056932 384219613 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774293 COc1ccc(F)cc1-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C18H15FN4O4/c1-26-16-5-3-11(19)7-13(16)14-9-18(21-10-20-14)22-12-4-6-17(27-2)15(8-12)23(24)25/h3-10H,1-2H3,(H,20,21,22) QRBWLFJCXJSBAA-UHFFFAOYSA-N 316246 US10294218, Example 74::US9617225, Example 74::[6-(5-Fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316246&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979491 384219614 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774294 COc1ccc(Nc2cc(ncn2)-c2cc(F)ccc2OC)cc1N InChI=1S/C18H17FN4O2/c1-24-16-5-3-11(19)7-13(16)15-9-18(22-10-21-15)23-12-4-6-17(25-2)14(20)8-12/h3-10H,20H2,1-2H3,(H,21,22,23) XMCWMZMZPXNMFT-UHFFFAOYSA-N 316247 N1-[6-(5-Fluoro-2-methoxy-phenyl)- pyrimidin-4-yl]-4-methoxy-benzene-1,3- diamine::US10294218, Example 75::US9617225, Example 75 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316247&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89981830 384219615 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774295 COc1ccc(Nc2cc(ncn2)-c2ccccc2Oc2ccccc2)cc1[N+]([O-])=O InChI=1S/C23H18N4O4/c1-30-22-12-11-16(13-20(22)27(28)29)26-23-14-19(24-15-25-23)18-9-5-6-10-21(18)31-17-7-3-2-4-8-17/h2-15H,1H3,(H,24,25,26) YBSMHDLXDDRVEC-UHFFFAOYSA-N 316248 (4-Methoxy-3-nitro-phenyl)-[6-(2-phenoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 76::US9617225, Example 76 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316248&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979059 384219616 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774296 COc1ccc(Nc2cc(ncn2)-c2ccccc2Oc2ccccc2)cc1N InChI=1S/C23H20N4O2/c1-28-22-12-11-16(13-19(22)24)27-23-14-20(25-15-26-23)18-9-5-6-10-21(18)29-17-7-3-2-4-8-17/h2-15H,24H2,1H3,(H,25,26,27) GXSAMRSHJOTYSB-UHFFFAOYSA-N 316249 4-Methoxy-N1-[6-(2-phenoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 77::US9617225, Example 77 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316249&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335145 384219617 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774297 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC(C)C)cc1[N+]([O-])=O InChI=1S/C20H20N4O4/c1-13(2)28-18-7-5-4-6-15(18)16-11-20(22-12-21-16)23-14-8-9-19(27-3)17(10-14)24(25)26/h4-13H,1-3H3,(H,21,22,23) GWVUMDUNJUBVRM-UHFFFAOYSA-N 316250 US10294218, Example 78::US9617225, Example 78::[6-(2-Isopropoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316250&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979611 384219618 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774298 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC(C)C)cc1N InChI=1S/C20H22N4O2/c1-13(2)26-18-7-5-4-6-15(18)17-11-20(23-12-22-17)24-14-8-9-19(25-3)16(21)10-14/h4-13H,21H2,1-3H3,(H,22,23,24) NJCDGFOWBZHIDI-UHFFFAOYSA-N 316251 N1-[6-(2-Isopropoxy-phenyl)-pyrimidin- 4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 79::US9617225, Example 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316251&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335146 384219619 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774299 COc1ccc(Nc2cc(ncn2)-c2cccc(F)c2OC)cc1[N+]([O-])=O InChI=1S/C18H15FN4O4/c1-26-16-7-6-11(8-15(16)23(24)25)22-17-9-14(20-10-21-17)12-4-3-5-13(19)18(12)27-2/h3-10H,1-2H3,(H,20,21,22) APBLZKRLMNYUNR-UHFFFAOYSA-N 316252 US10294218, Example 80::US9617225, Example 80::[6-(3-Fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316252&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979212 384219620 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774300 COc1ccc(Nc2cc(ncn2)-c2cccc(F)c2OC)cc1N InChI=1S/C18H17FN4O2/c1-24-16-7-6-11(8-14(16)20)23-17-9-15(21-10-22-17)12-4-3-5-13(19)18(12)25-2/h3-10H,20H2,1-2H3,(H,21,22,23) RMVHTSBBORPJAE-UHFFFAOYSA-N 316253 N1-[6-(3-Fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 81::US9617225, Example 81 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316253&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983801 384219621 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774301 COc1ccc(Nc2cc(ncn2)-c2cc(F)c(F)cc2OC)cc1[N+]([O-])=O InChI=1S/C18H14F2N4O4/c1-27-16-4-3-10(5-15(16)24(25)26)23-18-8-14(21-9-22-18)11-6-12(19)13(20)7-17(11)28-2/h3-9H,1-2H3,(H,21,22,23) LOZZWEDPEBMZQV-UHFFFAOYSA-N 316254 US10294218, Example 82::US9617225, Example 82::[6-(4,5-Difluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316254&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978888 384219622 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774302 COc1ccc(Nc2cc(ncn2)-c2cc(F)c(F)cc2OC)cc1N InChI=1S/C18H16F2N4O2/c1-25-16-4-3-10(5-14(16)21)24-18-8-15(22-9-23-18)11-6-12(19)13(20)7-17(11)26-2/h3-9H,21H2,1-2H3,(H,22,23,24) MUAWAKAMHOPSDF-UHFFFAOYSA-N 316255 N1-[6-(4,5-Difluoro-2-methoxy-phenyl)- pyrimidin-4-yl]-4-methoxy-benzene-1,3- diamine::US10294218, Example 83::US9617225, Example 83 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316255&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89981832 384219623 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774303 COc1ccc(Nc2cc(ncn2)-c2cc(F)c(F)cc2OC)cc1NC=O InChI=1S/C19H16F2N4O3/c1-27-17-4-3-11(5-16(17)24-10-26)25-19-8-15(22-9-23-19)12-6-13(20)14(21)7-18(12)28-2/h3-10H,1-2H3,(H,24,26)(H,22,23,25) OGKRZVTZKBHVKD-UHFFFAOYSA-N 316256 N-{5-[6-(4,5-Difluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl}-formamide::US10294218, Example 84::US9617225, Example 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316256&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979337 384219624 C06049 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774304 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC(C)C)cc1[N+]([O-])=O InChI=1S/C20H19FN4O4/c1-12(2)29-19-8-13(21)4-6-15(19)16-10-20(23-11-22-16)24-14-5-7-18(28-3)17(9-14)25(26)27/h4-12H,1-3H3,(H,22,23,24) XZHVHCOZUWCXDI-UHFFFAOYSA-N 316257 US10294218, Example 85::US9617225, Example 85::[6-(4-Fluoro-2-isopropoxy-phenyl)-pyrimidin-4-yl]-(4-methoxy-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316257&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89980329 384219625 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774305 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC(C)C)cc1N InChI=1S/C20H21FN4O2/c1-12(2)27-19-8-13(21)4-6-15(19)17-10-20(24-11-23-17)25-14-5-7-18(26-3)16(22)9-14/h4-12H,22H2,1-3H3,(H,23,24,25) LUPDYBHOPMJCGX-UHFFFAOYSA-N 316258 N1-[6-(4-Fluoro-2-isopropoxy-phenyl)-pyrimidin-4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 86::US9617225, Example 86 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316258&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983806 384219626 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774306 COc1ccccc1-c1cc(Nc2cc(F)c(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C18H15FN4O4/c1-26-16-6-4-3-5-12(16)14-9-17(21-10-20-14)22-11-7-13(19)18(27-2)15(8-11)23(24)25/h3-10H,1-2H3,(H,20,21,22) RPIATZZFIIETSP-UHFFFAOYSA-N 316259 (3-Fluoro-4-methoxy-5-nitro-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 87::US9617225, Example 87 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316259&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979374 384219627 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774307 COc1ccccc1-c1cc(Nc2cc(N)c(OC)c(F)c2)ncn1 InChI=1S/C18H17FN4O2/c1-24-16-6-4-3-5-12(16)15-9-17(22-10-21-15)23-11-7-13(19)18(25-2)14(20)8-11/h3-10H,20H2,1-2H3,(H,21,22,23) FWPLUJPWBJGFDG-UHFFFAOYSA-N 316260 5-Fluoro-4-methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 88::US9617225, Example 88 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316260&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979705 384219628 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774308 CCOc1cc(F)ccc1-c1cc(Nc2cc(N)c(OC)c(F)c2)ncn1 InChI=1S/C19H18F2N4O2/c1-3-27-17-6-11(20)4-5-13(17)16-9-18(24-10-23-16)25-12-7-14(21)19(26-2)15(22)8-12/h4-10H,3,22H2,1-2H3,(H,23,24,25) PCWAUWQCGVBBHC-UHFFFAOYSA-N 316261 N1-[6-(2-Ethoxy-4-fluoro-phenyl)-pyrimidin-4-yl]-5-fluoro-4-methoxy-benzene-1,3-diamine::US10294218, Example 89::US9617225, Example 89 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316261&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983757 384219629 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774309 COc1cc(F)ccc1-c1cc(Nc2cc(N)c(OC)c(F)c2)ncn1 InChI=1S/C18H16F2N4O2/c1-25-16-5-10(19)3-4-12(16)15-8-17(23-9-22-15)24-11-6-13(20)18(26-2)14(21)7-11/h3-9H,21H2,1-2H3,(H,22,23,24) SSWIXSVLCVWKPI-UHFFFAOYSA-N 316262 5-Fluoro-N1-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 90::US9617225, Example 90 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316262&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89980369 384219630 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774310 COc1ccc(F)cc1-c1cc(Nc2cc(N)c(OC)c(F)c2)ncn1 InChI=1S/C18H16F2N4O2/c1-25-16-4-3-10(19)5-12(16)15-8-17(23-9-22-15)24-11-6-13(20)18(26-2)14(21)7-11/h3-9H,21H2,1-2H3,(H,22,23,24) QGPBYXPWFPCHHZ-UHFFFAOYSA-N 316263 5-Fluoro-N1-[6-(5-fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 91::US9617225, Example 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316263&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978885 384219631 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774311 COc1cc(F)c(Nc2cc(ncn2)-c2ccccc2OC)cc1N InChI=1S/C18H17FN4O2/c1-24-16-6-4-3-5-11(16)14-9-18(22-10-21-14)23-15-8-13(20)17(25-2)7-12(15)19/h3-10H,20H2,1-2H3,(H,21,22,23) BIIFDCGAIKKSIL-UHFFFAOYSA-N 316264 4-Fluoro-6-methoxy-N3-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 92::US9617225, Example 92 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979676 384219632 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774312 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC(C)=O InChI=1S/C20H19N3O4/c1-13(24)27-19-10-14(8-9-18(19)26-3)23-20-11-16(21-12-22-20)15-6-4-5-7-17(15)25-2/h4-12H,1-3H3,(H,21,22,23) CLLIDSZADJKRKR-UHFFFAOYSA-N 316265 Acetic acid 2-methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl ester::US10294218, Example 93::US9617225, Example 93 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316265&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979267 384219633 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774313 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC(=O)N(C)C InChI=1S/C21H22N4O4/c1-25(2)21(26)29-19-11-14(9-10-18(19)28-4)24-20-12-16(22-13-23-20)15-7-5-6-8-17(15)27-3/h5-13H,1-4H3,(H,22,23,24) RWBGSXRHGMVSNE-UHFFFAOYSA-N 316266 Dimethyl-carbamic acid 2-methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl ester::US10294218, Example 94::US9617225, Example 94 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316266&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73335147 384219634 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774314 COC(=O)Oc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C20H19N3O5/c1-25-16-7-5-4-6-14(16)15-11-19(22-12-21-15)23-13-8-9-17(26-2)18(10-13)28-20(24)27-3/h4-12H,1-3H3,(H,21,22,23) DMVSBGXTXSAECK-UHFFFAOYSA-N 316267 Carbonic acid 2-methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl ester methyl ester::US10294218, Example 95::US9617225, Example 95 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316267&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979255 384219635 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774315 COc1ccccc1-c1cc(Nc2ccc(Oc3ccccc3)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C23H18N4O4/c1-30-21-10-6-5-9-18(21)19-14-23(25-15-24-19)26-16-11-12-22(20(13-16)27(28)29)31-17-7-3-2-4-8-17/h2-15H,1H3,(H,24,25,26) OUGRIZGSRAMYLE-UHFFFAOYSA-N 316268 US10294218, Example 96::US9617225, Example 96::[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-(3-nitro-4-phenoxy-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316268&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978909 384219636 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774316 COc1ccccc1-c1cc(Nc2ccc(Oc3ccccc3)c(N)c2)ncn1 InChI=1S/C23H20N4O2/c1-28-21-10-6-5-9-18(21)20-14-23(26-15-25-20)27-16-11-12-22(19(24)13-16)29-17-7-3-2-4-8-17/h2-15H,24H2,1H3,(H,25,26,27) HALQXORPYAZNFO-UHFFFAOYSA-N 316269 N1-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-4-phenoxy-benzene-1,3-diamine::US10294218, Example 97::US9617225, Example 97 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316269&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983761 384219637 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774317 COC(=O)N(C)c1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C21H22N4O4/c1-25(21(26)29-4)17-11-14(9-10-19(17)28-3)24-20-12-16(22-13-23-20)15-7-5-6-8-18(15)27-2/h5-13H,1-4H3,(H,22,23,24) HSHPDOXRJIYHAS-UHFFFAOYSA-N 316270 US10294218, Example 98::US9617225, Example 98::{2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-methyl-carbamic acid methyl ester Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316270&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979562 384219638 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774318 CNc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OC InChI=1S/C19H20N4O2/c1-20-16-10-13(8-9-18(16)25-3)23-19-11-15(21-12-22-19)14-6-4-5-7-17(14)24-2/h4-12,20H,1-3H3,(H,21,22,23) QSTZTPPCYVIWBP-UHFFFAOYSA-N 316271 4-Methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-N3-methyl-benzene-1,3-diamine::US10294218, Example 99::US9617225, Example 99 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316271&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979182 384219639 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774319 CCOc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1[N+]([O-])=O InChI=1S/C19H18N4O4/c1-3-27-18-9-8-13(10-16(18)23(24)25)22-19-11-15(20-12-21-19)14-6-4-5-7-17(14)26-2/h4-12H,3H2,1-2H3,(H,20,21,22) RDPPDPIKSHNPQE-UHFFFAOYSA-N 316272 (4-Ethoxy-3-nitro-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 100::US9617225, Example 100 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316272&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979475 384219640 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774320 CCOc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1N InChI=1S/C19H20N4O2/c1-3-25-18-9-8-13(10-15(18)20)23-19-11-16(21-12-22-19)14-6-4-5-7-17(14)24-2/h4-12H,3,20H2,1-2H3,(H,21,22,23) IWRUDLHVEZCWSD-UHFFFAOYSA-N 316273 4-Ethoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 101::US9617225, Example 101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316273&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979111 384219641 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774321 COc1cc(F)ccc1-c1cc(Nc2ccc(F)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C17H12F2N4O3/c1-26-16-6-10(18)2-4-12(16)14-8-17(21-9-20-14)22-11-3-5-13(19)15(7-11)23(24)25/h2-9H,1H3,(H,20,21,22) PCGZTVDQXFUSDI-UHFFFAOYSA-N 316274 US10294218, Example 102::US9617225, Example 102::[6-(4-Fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-(4-fluoro-3-nitro-phenyl)-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316274&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979325 384219642 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774322 CCOc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1[N+]([O-])=O InChI=1S/C19H17FN4O4/c1-3-28-17-7-5-13(9-16(17)24(25)26)23-19-10-15(21-11-22-19)14-6-4-12(20)8-18(14)27-2/h4-11H,3H2,1-2H3,(H,21,22,23) ZLHGWYNNMICSBF-UHFFFAOYSA-N 316275 (4-Ethoxy-3-nitro-phenyl)-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 103::US9617225, Example 103 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316275&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979088 384219643 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774323 COc1cc(F)ccc1-c1cc(Nc2ccc(F)c(N)c2)ncn1 InChI=1S/C17H14F2N4O/c1-24-16-6-10(18)2-4-12(16)15-8-17(22-9-21-15)23-11-3-5-13(19)14(20)7-11/h2-9H,20H2,1H3,(H,21,22,23) AMYPUZHHGSFFNX-UHFFFAOYSA-N 316276 4-Fluoro-N1-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 104::US9617225, Example 104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316276&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978948 384219644 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774324 CCOc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1N InChI=1S/C19H19FN4O2/c1-3-26-17-7-5-13(9-15(17)21)24-19-10-16(22-11-23-19)14-6-4-12(20)8-18(14)25-2/h4-11H,3,21H2,1-2H3,(H,22,23,24) FDICFPBSKGWNJA-UHFFFAOYSA-N 316277 4-Ethoxy-N1-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine::US10294218, Example 105::US9617225, Example 105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316277&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979546 384219645 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774325 COc1ccccc1-c1cc(Nc2ccc(N(C)C)c(F)c2)ncn1 InChI=1S/C19H19FN4O/c1-24(2)17-9-8-13(10-15(17)20)23-19-11-16(21-12-22-19)14-6-4-5-7-18(14)25-3/h4-12H,1-3H3,(H,21,22,23) TVTAXSKFTDVEJK-UHFFFAOYSA-N 316278 2-Fluoro-N4-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-N1,N1-dimethyl-benzene-1,4-diamine::US10294218, Example 106::US9617225, Example 106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316278&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979208 384219646 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774326 COc1ccccc1-c1cc(Nc2ccc(Cl)c(O)c2)ncn1 InChI=1S/C17H14ClN3O2/c1-23-16-5-3-2-4-12(16)14-9-17(20-10-19-14)21-11-6-7-13(18)15(22)8-11/h2-10,22H,1H3,(H,19,20,21) DGPMAQPXDWGCRO-UHFFFAOYSA-N 316279 2-Chloro-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenol::US10294218, Example 107::US9617225, Example 107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316279&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979045 384219647 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774327 COc1ccccc1-c1cc(Nc2ccc(N(C)C)c(O)c2)ncn1 InChI=1S/C19H20N4O2/c1-23(2)16-9-8-13(10-17(16)24)22-19-11-15(20-12-21-19)14-6-4-5-7-18(14)25-3/h4-12,24H,1-3H3,(H,20,21,22) BTSKPUPMGBXONT-UHFFFAOYSA-N 316280 2-Dimethylamino-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenol::US10294218, Example 108::US9617225, Example 108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316280&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979355 384219648 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774328 COc1ccccc1-c1cc(Nc2ccc(N(C)C)c(c2)C(N)=O)ncn1 InChI=1S/C20H21N5O2/c1-25(2)17-9-8-13(10-15(17)20(21)26)24-19-11-16(22-12-23-19)14-6-4-5-7-18(14)27-3/h4-12H,1-3H3,(H2,21,26)(H,22,23,24) ZVUDFWGYGNNKLG-UHFFFAOYSA-N 316281 2-Dimethylamino-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 109::US9617225, Example 109 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979911 384219649 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774329 CCOc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1O InChI=1S/C19H19N3O3/c1-3-25-18-9-8-13(10-16(18)23)22-19-11-15(20-12-21-19)14-6-4-5-7-17(14)24-2/h4-12,23H,3H2,1-2H3,(H,20,21,22) CXKFIZZCQCVZSN-UHFFFAOYSA-N 316282 2-Ethoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenol::US10294218, Example 110::US9617225, Example 110 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316282&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979622 384219650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774330 CCOc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(N)=O InChI=1S/C20H20N4O3/c1-3-27-18-9-8-13(10-15(18)20(21)25)24-19-11-16(22-12-23-19)14-6-4-5-7-17(14)26-2/h4-12H,3H2,1-2H3,(H2,21,25)(H,22,23,24) LNOYVUPSJBUIPP-UHFFFAOYSA-N 316283 2-Ethoxy-5-[6-(2-methoxy-phenyl)- pyrimidin-4-ylamino]-benzamide::US10294218, Example 111::US9617225, Example 111 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316283&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979707 384219651 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774331 CCOc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1C(N)=O InChI=1S/C20H19FN4O3/c1-3-28-17-7-5-13(9-15(17)20(22)26)25-19-10-16(23-11-24-19)14-6-4-12(21)8-18(14)27-2/h4-11H,3H2,1-2H3,(H2,22,26)(H,23,24,25) VMRSZEYBIXKRMY-UHFFFAOYSA-N 316284 2-Ethoxy-5-[6-(4-fluoro-2-methoxy- phenyl)-pyrimidin-4-ylamino]- benzamide::US10294218, Example 112::US9617225, Example 112 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316284&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978982 384219652 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774332 COc1cc(F)ccc1-c1cc(Nc2ccc(N(C)C)c(c2)C(N)=O)ncn1 InChI=1S/C20H20FN5O2/c1-26(2)17-7-5-13(9-15(17)20(22)27)25-19-10-16(23-11-24-19)14-6-4-12(21)8-18(14)28-3/h4-11H,1-3H3,(H2,22,27)(H,23,24,25) MBCAOKHCWOIKOV-UHFFFAOYSA-N 316285 2-Dimethylamino-5-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 113::US9617225, Example 113 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316285&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979662 384219653 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774333 CCOc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1O InChI=1S/C19H18FN3O3/c1-3-26-17-7-5-13(9-16(17)24)23-19-10-15(21-11-22-19)14-6-4-12(20)8-18(14)25-2/h4-11,24H,3H2,1-2H3,(H,21,22,23) SYFMTNYFYYVIJA-UHFFFAOYSA-N 316286 2-Ethoxy-5-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenol::US10294218, Example 114::US9617225, Example 114 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316286&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979397 384219654 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774334 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1Br InChI=1S/C18H16BrN3O2/c1-23-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-17(24-2)14(19)9-12/h3-11H,1-2H3,(H,20,21,22) XZSZYLSSUJEOPH-UHFFFAOYSA-N 316287 (3-Bromo-4-methoxy-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 115::US9617225, Example 115 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316287&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978983 384219655 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774335 COc1ccccc1-c1cc(Nc2ccc(OC)c(c2)C2=CCNCC2)ncn1 InChI=1S/C23H24N4O2/c1-28-21-6-4-3-5-18(21)20-14-23(26-15-25-20)27-17-7-8-22(29-2)19(13-17)16-9-11-24-12-10-16/h3-9,13-15,24H,10-12H2,1-2H3,(H,25,26,27) YUVIMYFPLYEJEI-UHFFFAOYSA-N 316288 US10294218, Example 116::US9617225, Example 116::[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-[4-methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316288&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978960 384219656 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774336 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1NC(C)=O InChI=1S/C20H19FN4O3/c1-12(26)24-17-9-14(5-7-18(17)27-2)25-20-10-16(22-11-23-20)15-6-4-13(21)8-19(15)28-3/h4-11H,1-3H3,(H,24,26)(H,22,23,25) NJHYIEWCVXFHKV-UHFFFAOYSA-N 316289 N-{5-[6-(4-Fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl}-acetamide::US10294218, Example 117::US9617225, Example 117 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316289&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979712 384219657 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774337 COC(=O)Nc1cc(Nc2cc(ncn2)-c2ccc(F)cc2OC)ccc1OC InChI=1S/C20H19FN4O4/c1-27-17-7-5-13(9-16(17)25-20(26)29-3)24-19-10-15(22-11-23-19)14-6-4-12(21)8-18(14)28-2/h4-11H,1-3H3,(H,25,26)(H,22,23,24) KBYKSVQSFWZBRT-UHFFFAOYSA-N 316290 US10294218, Example 118::US9617225, Example 118::{5-[6-(4-Fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl}-carbamic acid methyl ester Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316290&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978902 384219658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774338 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1NC(N)=O InChI=1S/C19H18FN5O3/c1-27-16-6-4-12(8-15(16)25-19(21)26)24-18-9-14(22-10-23-18)13-5-3-11(20)7-17(13)28-2/h3-10H,1-2H3,(H3,21,25,26)(H,22,23,24) PXYLVUVPZBMYHW-UHFFFAOYSA-N 316291 US10294218, Example 119::US9617225, Example 119::{5-[6-(4-Fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl}-urea Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316291&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979311 384219659 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774339 COc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1OCc1ccccc1 InChI=1S/C25H23N3O3/c1-29-22-11-7-6-10-20(22)21-15-25(27-17-26-21)28-19-12-13-23(24(14-19)30-2)31-16-18-8-4-3-5-9-18/h3-15,17H,16H2,1-2H3,(H,26,27,28) AEFQQHQRCNMXNT-UHFFFAOYSA-N 316292 (4-Benzyloxy-3-methoxy-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine::US10294218, Example 120::US9617225, Example 120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316292&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978897 384219660 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774340 COc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1O InChI=1S/C18H17N3O3/c1-23-16-6-4-3-5-13(16)14-10-18(20-11-19-14)21-12-7-8-15(22)17(9-12)24-2/h3-11,22H,1-2H3,(H,19,20,21) OOAIRLPMRKYXJA-UHFFFAOYSA-N 316293 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenol::US10294218, Example 121::US9617225, Example 121 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316293&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978998 384219661 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774341 COc1ccc(Nc2cc(ncn2)-c2cc(F)ccc2OC)cc1O InChI=1S/C18H16FN3O3/c1-24-16-5-3-11(19)7-13(16)14-9-18(21-10-20-14)22-12-4-6-17(25-2)15(23)8-12/h3-10,23H,1-2H3,(H,20,21,22) JSSAKAHJQZZLFN-UHFFFAOYSA-N 316294 5-[6-(5-Fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenol::US10294218, Example 122::US9617225, Example 122 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316294&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979023 384219662 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774342 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1O InChI=1S/C18H16FN3O3/c1-24-16-6-4-12(8-15(16)23)22-18-9-14(20-10-21-18)13-5-3-11(19)7-17(13)25-2/h3-10,23H,1-2H3,(H,20,21,22) UTEYHFBFBLPDEN-UHFFFAOYSA-N 316295 5-[6-(4-Fluoro-2-methoxy-phenyl)- pyrimidin-4-ylamino]-2-methoxy-phenol::US10294218, Example 123::US9617225, Example 123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316295&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979884 384219663 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774343 CCOc1ccccc1-c1cc(Nc2ccc(OC)c(O)c2)ncn1 InChI=1S/C19H19N3O3/c1-3-25-17-7-5-4-6-14(17)15-11-19(21-12-20-15)22-13-8-9-18(24-2)16(23)10-13/h4-12,23H,3H2,1-2H3,(H,20,21,22) DDXRCBHNJFXCGC-UHFFFAOYSA-N 316296 5-[6-(2-Ethoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenol::US10294218, Example 124::US9617225, Example 124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316296&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979336 384219664 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774344 COC(=O)Oc1cc(Nc2cc(ncn2)-c2ccc(F)cc2OC)ccc1OC InChI=1S/C20H18FN3O5/c1-26-16-7-5-13(9-18(16)29-20(25)28-3)24-19-10-15(22-11-23-19)14-6-4-12(21)8-17(14)27-2/h4-11H,1-3H3,(H,22,23,24) YWVISDPSYMNUPJ-UHFFFAOYSA-N 316297 Carbonic acid 5-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl ester methyl ester::US10294218, Example 125::US9617225, Example 125 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316297&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979133 384219665 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774345 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1OC(C)=O InChI=1S/C20H18FN3O4/c1-12(25)28-19-9-14(5-7-17(19)26-2)24-20-10-16(22-11-23-20)15-6-4-13(21)8-18(15)27-3/h4-11H,1-3H3,(H,22,23,24) VKQFKXZUGHMIJU-UHFFFAOYSA-N 316298 Acetic acid 5-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl ester::US10294218, Example 126::US9617225, Example 126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316298&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979885 384219666 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774346 COc1ccc(Nc2cc(ncn2)-c2cc(F)ccc2OC)cc1C(N)=O InChI=1S/C19H17FN4O3/c1-26-16-5-3-11(20)7-13(16)15-9-18(23-10-22-15)24-12-4-6-17(27-2)14(8-12)19(21)25/h3-10H,1-2H3,(H2,21,25)(H,22,23,24) RFEJSUJXYSYBIT-UHFFFAOYSA-N 316299 5-[6-(5-Fluoro-2-methoxy-phenyl)- pyrimidin-4-ylamino]-2-methoxy- benzamide::US10294218, Example 127::US9617225, Example 127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979225 384219667 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774347 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1C(N)=O InChI=1S/C19H17FN4O3/c1-26-16-6-4-12(8-14(16)19(21)25)24-18-9-15(22-10-23-18)13-5-3-11(20)7-17(13)27-2/h3-10H,1-2H3,(H2,21,25)(H,22,23,24) ZFCHUAOFIRTYII-UHFFFAOYSA-N 316300 5-[6-(4-Fluoro-2-methoxy-phenyl)- pyrimidin-4-ylamino]-2-methoxy- benzamide::US10294218, Example 128::US9617225, Example 128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316300&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979438 384219668 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774348 CCOc1ccccc1-c1cc(Nc2ccc(OC)c(c2)C(N)=O)ncn1 InChI=1S/C20H20N4O3/c1-3-27-18-7-5-4-6-14(18)16-11-19(23-12-22-16)24-13-8-9-17(26-2)15(10-13)20(21)25/h4-12H,3H2,1-2H3,(H2,21,25)(H,22,23,24) JYPPBSTUNBNCQP-UHFFFAOYSA-N 316301 5-[6-(2-Ethoxy-phenyl)-pyrimidin-4- ylamino]-2-methoxy-benzamide::US10294218, Example 129::US9617225, Example 129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316301&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978870 384219669 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774349 CCOc1cc(F)ccc1-c1cc(Nc2ccc(OC)c(c2)C(N)=O)ncn1 InChI=1S/C20H19FN4O3/c1-3-28-18-8-12(21)4-6-14(18)16-10-19(24-11-23-16)25-13-5-7-17(27-2)15(9-13)20(22)26/h4-11H,3H2,1-2H3,(H2,22,26)(H,23,24,25) HOBPRFASLSETAO-UHFFFAOYSA-N 316302 5-[6-(2-Ethoxy-4-fluoro-phenyl)- pyrimidin-4-ylamino]-2-methoxy- benzamide::US10294218, Example 130::US9617225, Example 130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316302&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978895 384219670 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774350 CCOc1ccc(F)cc1-c1cc(Nc2ccc(OC)c(c2)C(N)=O)ncn1 InChI=1S/C20H19FN4O3/c1-3-28-18-6-4-12(21)8-14(18)16-10-19(24-11-23-16)25-13-5-7-17(27-2)15(9-13)20(22)26/h4-11H,3H2,1-2H3,(H2,22,26)(H,23,24,25) YHPFXQLAPWBMCG-UHFFFAOYSA-N 316303 5-[6-(2-Ethoxy-5-fluoro-phenyl)- pyrimidin-4-ylamino]-2-methoxy- benzamide::US10294218, Example 131::US9617225, Example 131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316303&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978853 384219671 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774351 COc1ccccc1-c1cc(Nc2ccc(C(N)=O)c(Cl)c2)ncn1 InChI=1S/C18H15ClN4O2/c1-25-16-5-3-2-4-13(16)15-9-17(22-10-21-15)23-11-6-7-12(18(20)24)14(19)8-11/h2-10H,1H3,(H2,20,24)(H,21,22,23) OHZMEZTVTDODOC-UHFFFAOYSA-N 316304 2-Chloro-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 132::US9617225, Example 132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316304&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978958 384219672 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774352 COC(=O)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC InChI=1S/C20H19N3O4/c1-25-17-7-5-4-6-14(17)16-11-19(22-12-21-16)23-13-8-9-15(20(24)27-3)18(10-13)26-2/h4-12H,1-3H3,(H,21,22,23) HDQCWWAIRDKFJS-UHFFFAOYSA-N 316305 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid methyl ester::US10294218, Example 133::US9617225, Example 133 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316305&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 68915224 384219673 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774353 CNC(=O)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC InChI=1S/C20H20N4O3/c1-21-20(25)15-9-8-13(10-18(15)27-3)24-19-11-16(22-12-23-19)14-6-4-5-7-17(14)26-2/h4-12H,1-3H3,(H,21,25)(H,22,23,24) WZYMYYIKLTZIER-UHFFFAOYSA-N 316306 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-N-methyl-benzamide::US10294218, Example 134::US9617225, Example 134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316306&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979360 384219674 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774354 COc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1C(=O)NCCO InChI=1S/C21H22N4O4/c1-28-18-6-4-3-5-15(18)17-12-20(24-13-23-17)25-14-7-8-16(19(11-14)29-2)21(27)22-9-10-26/h3-8,11-13,26H,9-10H2,1-2H3,(H,22,27)(H,23,24,25) CZZUDKKZSUZKFN-UHFFFAOYSA-N 316307 N-(2-Hydroxy-ethyl)-2-methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 135::US9617225, Example 135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316307&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979253 384219675 C04080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774355 COc1ccccc1-c1cc(Nc2ccc(C(N)=O)c(OC)c2)ncn1 InChI=1S/C19H18N4O3/c1-25-16-6-4-3-5-13(16)15-10-18(22-11-21-15)23-12-7-8-14(19(20)24)17(9-12)26-2/h3-11H,1-2H3,(H2,20,24)(H,21,22,23) YVBAASMJXPJMFM-UHFFFAOYSA-N 316308 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 136::US9617225, Example 136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316308&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89980254 384219676 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774356 COc1ccccc1-c1cc(Nc2cc(F)c(OC)c(c2)C(N)=O)ncn1 InChI=1S/C19H17FN4O3/c1-26-16-6-4-3-5-12(16)15-9-17(23-10-22-15)24-11-7-13(19(21)25)18(27-2)14(20)8-11/h3-10H,1-2H3,(H2,21,25)(H,22,23,24) HXWKSOCZDQWXTF-UHFFFAOYSA-N 316309 3-Fluoro-2-methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 137::US9617225, Example 137 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978981 384219677 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774357 COc1cc(F)ccc1-c1cc(Nc2cc(F)c(OC)c(c2)C(N)=O)ncn1 InChI=1S/C19H16F2N4O3/c1-27-16-5-10(20)3-4-12(16)15-8-17(24-9-23-15)25-11-6-13(19(22)26)18(28-2)14(21)7-11/h3-9H,1-2H3,(H2,22,26)(H,23,24,25) RYWFQNCXOPRASL-UHFFFAOYSA-N 316310 3-Fluoro-5-[6-(4-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-benzamide::US10294218, Example 138::US9617225, Example 138 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316310&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979456 384219678 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774358 CCOc1cc(F)ccc1-c1cc(Nc2cc(F)c(OC)c(c2)C(N)=O)ncn1 InChI=1S/C20H18F2N4O3/c1-3-29-17-6-11(21)4-5-13(17)16-9-18(25-10-24-16)26-12-7-14(20(23)27)19(28-2)15(22)8-12/h4-10H,3H2,1-2H3,(H2,23,27)(H,24,25,26) PTKYIKABGMKTPE-UHFFFAOYSA-N 316311 5-[6-(2-Ethoxy-4-fluoro-phenyl)-pyrimidin-4-ylamino]-3-fluoro-2-methoxy-benzamide::US10294218, Example 139::US9617225, Example 139 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316311&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979516 384219679 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774359 COc1ccc(F)cc1-c1cc(Nc2cc(F)c(OC)c(c2)C(N)=O)ncn1 InChI=1S/C19H16F2N4O3/c1-27-16-4-3-10(20)5-12(16)15-8-17(24-9-23-15)25-11-6-13(19(22)26)18(28-2)14(21)7-11/h3-9H,1-2H3,(H2,22,26)(H,23,24,25) SQCMKCZYDOHJII-UHFFFAOYSA-N 316312 3-Fluoro-5-[6-(5-fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-benzamide::US10294218, Example 140::US9617225, Example 140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316312&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979449 384219680 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774360 CCOc1ccccc1-c1cc(Nc2cc(F)c(OC)c(c2)C(N)=O)ncn1 InChI=1S/C20H19FN4O3/c1-3-28-17-7-5-4-6-13(17)16-10-18(24-11-23-16)25-12-8-14(20(22)26)19(27-2)15(21)9-12/h4-11H,3H2,1-2H3,(H2,22,26)(H,23,24,25) GCTFPBXZMVIOKF-UHFFFAOYSA-N 316313 5-[6-(2-Ethoxy-phenyl)-pyrimidin-4- ylamino]-3-fluoro-2-methoxy- benzamide::US10294218, Example 141::US9617225, Example 141 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316313&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979298 384219681 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774361 CCOc1ccc(F)cc1-c1cc(Nc2cc(F)c(OC)c(c2)C(N)=O)ncn1 InChI=1S/C20H18F2N4O3/c1-3-29-17-5-4-11(21)6-13(17)16-9-18(25-10-24-16)26-12-7-14(20(23)27)19(28-2)15(22)8-12/h4-10H,3H2,1-2H3,(H2,23,27)(H,24,25,26) PTIOYXHWLYEKFP-UHFFFAOYSA-N 316314 5-[6-(2-Ethoxy-5-fluoro-phenyl)- pyrimidin-4-ylamino]-3-fluoro-2- methoxy-benzamide::US10294218, Example 142::US9617225, Example 142 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316314&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979796 384219682 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774362 COc1ccccc1-c1cc(Nc2cc(C(N)=O)c(OC)cc2F)ncn1 InChI=1S/C19H17FN4O3/c1-26-16-6-4-3-5-11(16)14-9-18(23-10-22-14)24-15-7-12(19(21)25)17(27-2)8-13(15)20/h3-10H,1-2H3,(H2,21,25)(H,22,23,24) OKQDRIFENWNLBC-UHFFFAOYSA-N 316315 4-Fluoro-2-methoxy-5-[6-(2-methoxy- phenyl)-pyrimidin-4-ylamino]- benzamide::US10294218, Example 143::US9617225, Example 143 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316315&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89980023 384219683 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774363 COc1ccc(F)cc1-c1cc(Nc2cc(C(N)=O)c(OC)cc2F)ncn1 InChI=1S/C19H16F2N4O3/c1-27-16-4-3-10(20)5-11(16)14-8-18(24-9-23-14)25-15-6-12(19(22)26)17(28-2)7-13(15)21/h3-9H,1-2H3,(H2,22,26)(H,23,24,25) JYBXODRXBKNRDJ-UHFFFAOYSA-N 316316 4-Fluoro-5-[6-(5-fluoro-2-methoxy- phenyl)-pyrimidin-4-ylamino]-2- methoxy-benzamide::US10294218, Example 144::US9617225, Example 144 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316316&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979026 384219684 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774364 CCOc1ccccc1-c1cc(Nc2cc(C(N)=O)c(OC)cc2F)ncn1 InChI=1S/C20H19FN4O3/c1-3-28-17-7-5-4-6-12(17)15-10-19(24-11-23-15)25-16-8-13(20(22)26)18(27-2)9-14(16)21/h4-11H,3H2,1-2H3,(H2,22,26)(H,23,24,25) PSZSZDZJLJZOLP-UHFFFAOYSA-N 316317 5-[6-(2-Ethoxy-phenyl)-pyrimidin-4- ylamino]-4-fluoro-2-methoxy- benzamide::US10294218, Example 145::US9617225, Example 145 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316317&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979486 384219685 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774365 COc1cc(F)c(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1C(N)=O InChI=1S/C19H16F2N4O3/c1-27-16-5-10(20)3-4-11(16)14-8-18(24-9-23-14)25-15-6-12(19(22)26)17(28-2)7-13(15)21/h3-9H,1-2H3,(H2,22,26)(H,23,24,25) WUKHXYWKXVPSKC-UHFFFAOYSA-N 316318 4-Fluoro-5-[6-(4-fluoro-2-methoxy- phenyl)-pyrimidin-4-ylamino]-2- methoxy-benzamide::US10294218, Example 146::US9617225, Example 146 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316318&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978843 384219686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774366 CCOc1cc(F)ccc1-c1cc(Nc2cc(C(N)=O)c(OC)cc2F)ncn1 InChI=1S/C20H18F2N4O3/c1-3-29-18-6-11(21)4-5-12(18)15-9-19(25-10-24-15)26-16-7-13(20(23)27)17(28-2)8-14(16)22/h4-10H,3H2,1-2H3,(H2,23,27)(H,24,25,26) LDWLFFCKBXGAQE-UHFFFAOYSA-N 316319 5-[6-(2-Ethoxy-4-fluoro-phenyl)- pyrimidin-4-ylamino]-4-fluoro-2- methoxy-benzamide::US10294218, Example 147::US9617225, Example 147 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316319&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979376 384219687 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774367 CCOc1ccc(F)cc1-c1cc(Nc2cc(C(N)=O)c(OC)cc2F)ncn1 InChI=1S/C20H18F2N4O3/c1-3-29-17-5-4-11(21)6-12(17)15-9-19(25-10-24-15)26-16-7-13(20(23)27)18(28-2)8-14(16)22/h4-10H,3H2,1-2H3,(H2,23,27)(H,24,25,26) WXKZLYFMGZQRKP-UHFFFAOYSA-N 316320 5-[6-(2-Ethoxy-5-fluoro-phenyl)-pyrimidin-4-ylamino]-4-fluoro-2-methoxy-benzamide::US10294218, Example 148::US9617225, Example 148 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316320&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979041 384219688 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774368 CCC(CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24) BTIHMVBBUGXLCJ-UHFFFAOYSA-N 7585 (R,S)-Roscovitine::2,6,9-Trisubstituted purine deriv. 27::2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::CHEMBL52387::US10294218, Example Roscovitine::US9617225, Roscovitine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 5097 11108369 CHEMBL52387 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774369 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <100 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774370 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CN1C(=O)c2ccccc2C1=O InChI=1S/C27H22N4O4/c1-34-23-12-11-18(13-17(23)15-31-26(32)19-7-3-4-8-20(19)27(31)33)30-25-14-22(28-16-29-25)21-9-5-6-10-24(21)35-2/h3-14,16H,15H2,1-2H3,(H,28,29,30) RMMKDAOHCOETTH-UHFFFAOYSA-N 316175 2-(2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzyl)isoindoline-1,3-dione::US10294218, Example 3::US9617225, Example 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316175&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334952 384219543 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774371 COc1ccccc1-c1cc(Nc2ccc(OC)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C18H16N4O4/c1-25-16-6-4-3-5-13(16)14-10-18(20-11-19-14)21-12-7-8-17(26-2)15(9-12)22(23)24/h3-11H,1-2H3,(H,19,20,21) ZHFNQFDJLZJRPE-UHFFFAOYSA-N 316183 N-(4-methoxy-3-nitrophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine::US10294218, Example 11::US9617225, Example 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979282 384219551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774372 COc1ccccc1-c1cc(Nc2ccc(O)c(c2)[N+]([O-])=O)ncn1 InChI=1S/C17H14N4O4/c1-25-16-5-3-2-4-12(16)13-9-17(19-10-18-13)20-11-6-7-15(22)14(8-11)21(23)24/h2-10,22H,1H3,(H,18,19,20) DMDBRGXBQUMBAY-UHFFFAOYSA-N 316184 4-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-nitrophenol::US10294218, Example 12::US9617225, Example 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316184&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979473 384219552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774373 COc1ccccc1-c1cc(Nc2ccc(N(C)C)c(Cn3cnc4ccccc34)c2)ncn1 InChI=1S/C27H26N6O/c1-32(2)24-13-12-20(14-19(24)16-33-18-30-22-9-5-6-10-25(22)33)31-27-15-23(28-17-29-27)21-8-4-7-11-26(21)34-3/h4-15,17-18H,16H2,1-3H3,(H,28,29,31) TVLKGSNODYWKDT-UHFFFAOYSA-N 316214 2-((1H-benzo[d]imidazol-1-yl(methyl)-N4-(6-(2-methoxyphenyl)pyrimidin-4-yl)-N1,N1-dimethylbenzene-1,4-diamine::US10294218, Example 42::US9617225, Example 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316214&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979411 384219582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774374 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1CN InChI=1S/C19H20N4O2/c1-24-17-8-7-14(9-13(17)11-20)23-19-10-16(21-12-22-19)15-5-3-4-6-18(15)25-2/h3-10,12H,11,20H2,1-2H3,(H,21,22,23) JIAIGGXLKACTDG-UHFFFAOYSA-N 316215 N-(3-(aminomethyl)-4- methoxyphenyl)-6-(2- methoxyphenyl)pyrimidin- 4-amine::US10294218, Example 43::US9617225, Example 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316215&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979320 384219583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774375 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(=O)N(C)N InChI=1S/C20H21N5O3/c1-25(21)20(26)15-10-13(8-9-18(15)28-3)24-19-11-16(22-12-23-19)14-6-4-5-7-17(14)27-2/h4-12H,21H2,1-3H3,(H,22,23,24) PKXGORXSUSYYLX-UHFFFAOYSA-N 316218 2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid N-methyl-hydrazide::US10294218, Example 46::US9617225, Example 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316218&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979515 384219586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774376 COc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1C(O)=O InChI=1S/C19H17N3O4/c1-25-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-17(26-2)14(9-12)19(23)24/h3-11H,1-2H3,(H,23,24)(H,20,21,22) AONWAAATMIVVNJ-UHFFFAOYSA-N 316221 2-Methoxy-5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid::US10294218, Example 49::US9617225, Example 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316221&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73334956 384219589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774377 COc1cc(Nc2cc(ncn2)-c2ccccc2OC)ccc1N InChI=1S/C18H18N4O2/c1-23-16-6-4-3-5-13(16)15-10-18(21-11-20-15)22-12-7-8-14(19)17(9-12)24-2/h3-11H,19H2,1-2H3,(H,20,21,22) HGSMVNIIHBGJNM-UHFFFAOYSA-N 316231 2-Methoxy-N4-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,4-diamine::US10294218, Example 59::US9617225, Example 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316231&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979723 384219599 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774378 COc1ccc(Nc2cc(ncn2)-c2ccc(F)cc2OC)cc1N InChI=1S/C18H17FN4O2/c1-24-16-6-4-12(8-14(16)20)23-18-9-15(21-10-22-18)13-5-3-11(19)7-17(13)25-2/h3-10H,20H2,1-2H3,(H,21,22,23) BVQPMFIOQAQREE-UHFFFAOYSA-N 316236 N1-[6-(4-Fluoro-2-methoxy-phenyl)- pyrimidin-4-yl]-4-methoxy-benzene- 1,3-diamine::US10294218, Example 64::US9617225, Example 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316236&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89981829 384219604 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774379 COc1ccc(Nc2cc(ncn2)-c2ccccc2OCc2ccccc2)cc1N InChI=1S/C24H22N4O2/c1-29-23-12-11-18(13-20(23)25)28-24-14-21(26-16-27-24)19-9-5-6-10-22(19)30-15-17-7-3-2-4-8-17/h2-14,16H,15,25H2,1H3,(H,26,27,28) IJINHMPKIAUEJD-UHFFFAOYSA-N 316243 N1-[6-(2-Benzyloxy-phenyl)-pyrimidin-4-yl]-4-methoxy-benzene-1,3-diamine::US10294218, Example 71::US9617225, Example 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316243&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89983756 384219611 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774380 COC(=O)Nc1cc(Nc2cc(ncn2)-c2ccc(F)cc2OC)ccc1OC InChI=1S/C20H19FN4O4/c1-27-17-7-5-13(9-16(17)25-20(26)29-3)24-19-10-15(22-11-23-19)14-6-4-12(21)8-18(14)28-2/h4-11H,1-3H3,(H,25,26)(H,22,23,24) KBYKSVQSFWZBRT-UHFFFAOYSA-N 316290 US10294218, Example 118::US9617225, Example 118::{5-[6-(4-Fluoro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-methoxy-phenyl}-carbamic acid methyl ester Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316290&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978902 384219658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774381 COc1ccccc1-c1cc(Nc2ccc(C(N)=O)c(Cl)c2)ncn1 InChI=1S/C18H15ClN4O2/c1-25-16-5-3-2-4-13(16)15-9-17(22-10-21-15)23-11-6-7-12(18(20)24)14(19)8-11/h2-10H,1H3,(H2,20,24)(H,21,22,23) OHZMEZTVTDODOC-UHFFFAOYSA-N 316304 2-Chloro-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 132::US9617225, Example 132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316304&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89978958 384219672 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774382 COC(=O)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC InChI=1S/C20H19N3O4/c1-25-17-7-5-4-6-14(17)16-11-19(22-12-21-16)23-13-8-9-15(20(24)27-3)18(10-13)26-2/h4-12H,1-3H3,(H,21,22,23) HDQCWWAIRDKFJS-UHFFFAOYSA-N 316305 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid methyl ester::US10294218, Example 133::US9617225, Example 133 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316305&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 68915224 384219673 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774383 CNC(=O)c1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1OC InChI=1S/C20H20N4O3/c1-21-20(25)15-9-8-13(10-18(15)27-3)24-19-11-16(22-12-23-19)14-6-4-5-7-17(14)26-2/h4-12H,1-3H3,(H,21,25)(H,22,23,24) WZYMYYIKLTZIER-UHFFFAOYSA-N 316306 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-N-methyl-benzamide::US10294218, Example 134::US9617225, Example 134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316306&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89979360 384219674 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 774384 COc1ccccc1-c1cc(Nc2ccc(C(N)=O)c(OC)c2)ncn1 InChI=1S/C19H18N4O3/c1-25-16-6-4-3-5-13(16)15-10-18(22-11-21-15)23-12-7-8-14(19(20)24)17(9-12)26-2/h3-11H,1-2H3,(H2,20,24)(H,21,22,23) YVBAASMJXPJMFM-UHFFFAOYSA-N 316308 2-Methoxy-4-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzamide::US10294218, Example 136::US9617225, Example 136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2RB76X4 aid1798731 US10294218 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Õrfi, L; Keri, G VIROSTATICS SRL http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316308&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89980254 384219676 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50889609 CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)nc2n1C1CCCC1 InChI=1S/C31H32FN7O3/c1-38(2)27(40)25-17-19-18-33-30(37-26(19)39(25)24-5-3-4-6-24)36-23-13-11-22(12-14-23)35-29(42)31(15-16-31)28(41)34-21-9-7-20(32)8-10-21/h7-14,17-18,24H,3-6,15-16H2,1-2H3,(H,34,41)(H,35,42)(H,33,36,37) KXUNYNZTSOIXMY-UHFFFAOYSA-N 50268674 CHEMBL4078060 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2017.06.041 10.7270/Q2JS9SW3 28651979 Li, Y; Guo, Q; Zhang, C; Huang, Z; Wang, T; Wang, X; Wang, X; Xu, G; Liu, Y; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268674&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137628632 404914841 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50889610 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 197 ChEMBL 10.1016/j.bmcl.2017.06.041 10.7270/Q2JS9SW3 28651979 Li, Y; Guo, Q; Zhang, C; Huang, Z; Wang, T; Wang, X; Wang, X; Xu, G; Liu, Y; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822566 COc1ccc2ncc(-c3ccnc(SC)n3)n2n1 InChI=1S/C12H11N5OS/c1-18-11-4-3-10-14-7-9(17(10)16-11)8-5-6-13-12(15-8)19-2/h3-7H,1-2H3 DDXAAHDVGNFNMM-UHFFFAOYSA-N 50259330 CHEMBL4067420 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259330&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137633985 404339538 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822568 CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(NC(C)=O)c4)n3n2)c1 InChI=1S/C22H20N6O2/c1-14(29)24-17-6-3-5-16(11-17)20-13-23-22-10-9-21(27-28(20)22)26-19-8-4-7-18(12-19)25-15(2)30/h3-13H,1-2H3,(H,24,29)(H,25,30)(H,26,27) WEQRXDXDFLBIDK-UHFFFAOYSA-N 50259570 CHEMBL4102871 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137656868 404339585 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 767581 CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(C)cc2=O InChI=1S/C16H19NO5/c1-8-5-10(18)15-12(20)6-11(19)14(16(15)22-8)9-3-4-17(2)7-13(9)21/h5-6,9,13,19-21H,3-4,7H2,1-2H3 MOCVYVBNJQIVOV-UHFFFAOYSA-N 384315 US9932327, Compound Rohitukine (1) Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q25Q4ZDW aid1798601 US9932327 Vishwakarma, RA; Bharate, SB; Bhushan, S; Mondhe, DM; Jain, SK; Meena, S; Guru, SK; Pathania, AS; Kumar, S; Behl, A; Mintoo, MJ; Bharate, SS; Joshi, P The Council of Scientific & Industrial Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384315&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5387431 404853597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 767583 CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3 BIIVYFLTOXDAOV-UHFFFAOYSA-N 384357 US9932327, Compound Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q25Q4ZDW aid1798601 US9932327 Vishwakarma, RA; Bharate, SB; Bhushan, S; Mondhe, DM; Jain, SK; Meena, S; Guru, SK; Pathania, AS; Kumar, S; Behl, A; Mintoo, MJ; Bharate, SS; Joshi, P The Council of Scientific & Industrial Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384357&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5466794 404853630 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 767585 CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(Cl)cccc1Cl)cc2=O InChI=1S/C23H21Cl2NO5/c1-26-8-7-14(20(30)11-26)21-18(28)10-19(29)22-17(27)9-12(31-23(21)22)5-6-13-15(24)3-2-4-16(13)25/h2-6,9-10,14,20,28-30H,7-8,11H2,1H3/b6-5+ NFTJDXGFOUFNKG-AATRIKPKSA-N 384362 US9932327, Compound 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 US Patent 10.7270/Q25Q4ZDW aid1798601 US9932327 Vishwakarma, RA; Bharate, SB; Bhushan, S; Mondhe, DM; Jain, SK; Meena, S; Guru, SK; Pathania, AS; Kumar, S; Behl, A; Mintoo, MJ; Bharate, SS; Joshi, P The Council of Scientific & Industrial Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384362&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86272549 404853635 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 767587 CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(F)c(F)c(F)c(F)c1F)cc2=O InChI=1S/C23H18F5NO5/c1-29-5-4-10(15(33)8-29)16-13(31)7-14(32)17-12(30)6-9(34-23(16)17)2-3-11-18(24)20(26)22(28)21(27)19(11)25/h2-3,6-7,10,15,31-33H,4-5,8H2,1H3/b3-2+ DGSZFJJTBGMXJM-NSCUHMNNSA-N 384375 US9932327, Compound 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q25Q4ZDW aid1798601 US9932327 Vishwakarma, RA; Bharate, SB; Bhushan, S; Mondhe, DM; Jain, SK; Meena, S; Guru, SK; Pathania, AS; Kumar, S; Behl, A; Mintoo, MJ; Bharate, SS; Joshi, P The Council of Scientific & Industrial Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384375&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86272550 404853646 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 767589 CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1cccc(F)c1)cc2=O InChI=1S/C23H22FNO5/c1-25-8-7-16(20(29)12-25)21-18(27)11-19(28)22-17(26)10-15(30-23(21)22)6-5-13-3-2-4-14(24)9-13/h2-6,9-11,16,20,27-29H,7-8,12H2,1H3/b6-5+ PZXBPUJVINVNLU-AATRIKPKSA-N 384376 US9932327, Compound 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q25Q4ZDW aid1798601 US9932327 Vishwakarma, RA; Bharate, SB; Bhushan, S; Mondhe, DM; Jain, SK; Meena, S; Guru, SK; Pathania, AS; Kumar, S; Behl, A; Mintoo, MJ; Bharate, SS; Joshi, P The Council of Scientific & Industrial Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384376&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86272551 404853647 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822438 Clc1ccc2ncc(-c3cccc(C=O)c3)n2n1 InChI=1S/C13H8ClN3O/c14-12-4-5-13-15-7-11(17(13)16-12)10-3-1-2-9(6-10)8-18/h1-8H WLUFZZMAAGDSJH-UHFFFAOYSA-N 50259404 CHEMBL4076448 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7600 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89494280 404339550 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822441 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(\C=N\[C@@H](CC)CO)c3)n2n1 InChI=1S/C21H27N5O2/c1-3-17(13-27)22-11-15-6-5-7-16(10-15)19-12-23-21-9-8-20(25-26(19)21)24-18(4-2)14-28/h5-12,17-18,27-28H,3-4,13-14H2,1-2H3,(H,24,25)/b22-11+/t17-,18-/m0/s1 SZOYOCHRMSEEMG-AIHKSIKWSA-N 50259527 CHEMBL4070227 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 900 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137639546 404339576 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822537 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(c3)C(O)=O)n2n1 InChI=1S/C17H18N4O3/c1-2-13(10-22)19-15-6-7-16-18-9-14(21(16)20-15)11-4-3-5-12(8-11)17(23)24/h3-9,13,22H,2,10H2,1H3,(H,19,20)(H,23,24)/t13-/m0/s1 WCXPUTJZKXHALD-ZDUSSCGKSA-N 50259517 CHEMBL4092117 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259517&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137652970 404339567 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822538 CC[C@@H](CO)Nc1ccc2ncc(-c3ccsc3)n2n1 InChI=1S/C14H16N4OS/c1-2-11(8-19)16-13-3-4-14-15-7-12(18(14)17-13)10-5-6-20-9-10/h3-7,9,11,19H,2,8H2,1H3,(H,16,17)/t11-/m0/s1 OJYINLHOEHUFHI-NSHDSACASA-N 50259573 CHEMBL4097368 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 600 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137658970 404339588 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822548 CCOC(=O)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 InChI=1S/C15H13ClN4O2/c1-2-22-15(21)18-13-6-7-14-17-9-12(20(14)19-13)10-4-3-5-11(16)8-10/h3-9H,2H2,1H3,(H,18,19,21) DZYTUBQFYNVYGA-UHFFFAOYSA-N 50259558 CHEMBL4075509 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137652047 404339580 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822229 OCCN1CCN(CC1)c1ccc2ncc(-c3cccc(Cl)c3)n2n1 InChI=1S/C18H20ClN5O/c19-15-3-1-2-14(12-15)16-13-20-17-4-5-18(21-24(16)17)23-8-6-22(7-9-23)10-11-25/h1-5,12-13,25H,6-11H2 GVANUSPDJMCBIK-UHFFFAOYSA-N 50259559 CHEMBL4071013 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137639514 404339581 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822233 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C17H17F3N4O/c1-2-13(10-25)22-15-6-7-16-21-9-14(24(16)23-15)11-4-3-5-12(8-11)17(18,19)20/h3-9,13,25H,2,10H2,1H3,(H,22,23)/t13-/m0/s1 AMUFSGPBIFOSNV-ZDUSSCGKSA-N 50259411 CHEMBL4086402 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1700 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259411&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137644802 404339557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822234 Fc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C13H7F4N3/c14-11-4-5-12-18-7-10(20(12)19-11)8-2-1-3-9(6-8)13(15,16)17/h1-7H ZMXZKIHBCFYBTC-UHFFFAOYSA-N 50259360 CHEMBL4099677 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259360&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137661183 404339546 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822238 FC(F)(F)c1cccc(\C=C\c2cnc3ccc(Cl)nn23)c1 InChI=1S/C15H9ClF3N3/c16-13-6-7-14-20-9-12(22(14)21-13)5-4-10-2-1-3-11(8-10)15(17,18)19/h1-9H/b5-4+ SOIYEAXWSCNVLD-SNAWJCMRSA-N 50259359 CHEMBL4097256 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259359&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137661315 404339545 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822239 CC[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 InChI=1S/C15H17N5O/c1-2-12(10-21)18-14-5-6-15-17-9-13(20(15)19-14)11-4-3-7-16-8-11/h3-9,12,21H,2,10H2,1H3,(H,18,19)/t12-/m0/s1 PDJLHUHTIYCYTA-LBPRGKRZSA-N 50259410 CHEMBL4100956 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137659350 404339556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822243 COc1ccc2ncc(-c3ccnc(N)n3)n2n1 InChI=1S/C11H10N6O/c1-18-10-3-2-9-14-6-8(17(9)16-10)7-4-5-13-11(12)15-7/h2-6H,1H3,(H2,12,13,15) XLUOKXQFFGFGNB-UHFFFAOYSA-N 50259518 CHEMBL4077125 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5600 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137651668 404339568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822244 COc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C14H10F3N3O/c1-21-13-6-5-12-18-8-11(20(12)19-13)9-3-2-4-10(7-9)14(15,16)17/h2-8H,1H3 UIQXQUINYXMORH-UHFFFAOYSA-N 50259328 CHEMBL4098107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259328&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137661355 404339536 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822247 CC(C)[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 InChI=1S/C16H19N5O/c1-11(2)13(10-22)19-15-5-6-16-18-9-14(21(16)20-15)12-4-3-7-17-8-12/h3-9,11,13,22H,10H2,1-2H3,(H,19,20)/t13-/m1/s1 VBYRFFCBZNEHAL-CYBMUJFWSA-N 50259553 CHEMBL4074132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1200 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137640811 404339578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822403 CSc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 InChI=1S/C15H12N4S/c1-20-15-5-4-14-17-9-13(19(14)18-15)11-2-3-12-10(8-11)6-7-16-12/h2-9,16H,1H3 XNYOTZHBHJIMBV-UHFFFAOYSA-N 50259354 CHEMBL4090223 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259354&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137643514 404339541 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822414 Clc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 InChI=1S/C14H9ClN4/c15-13-3-4-14-17-8-12(19(14)18-13)10-1-2-11-9(7-10)5-6-16-11/h1-8,16H GQHOZRVWFHUSGK-UHFFFAOYSA-N 50259357 CHEMBL4091942 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259357&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90388565 404339543 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822416 COc1ccc2ncc(-c3ccnc(n3)[S+](C)[O-])n2n1 InChI=1S/C12H11N5O2S/c1-19-11-4-3-10-14-7-9(17(10)16-11)8-5-6-13-12(15-8)20(2)18/h3-7H,1-2H3 DRJPJGLJJAOLKO-UHFFFAOYSA-N 50259334 CHEMBL4062568 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137634818 404339539 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822422 Clc1cccc(c1)-c1cnc2ccc(nn12)N1CCC(CC1)N1CCCCC1 InChI=1S/C22H26ClN5/c23-18-6-4-5-17(15-18)20-16-24-21-7-8-22(25-28(20)21)27-13-9-19(10-14-27)26-11-2-1-3-12-26/h4-8,15-16,19H,1-3,9-14H2 CEHSVNYYAPNMFI-UHFFFAOYSA-N 50259560 CHEMBL4064988 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 620 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137635556 404339582 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822423 Clc1cccc(c1)-c1cnc2ccc(Cl)nn12 InChI=1S/C12H7Cl2N3/c13-9-3-1-2-8(6-9)10-7-15-12-5-4-11(14)16-17(10)12/h1-7H OEQGSMAROCJMFY-UHFFFAOYSA-N 50259362 CHEMBL4061394 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4800 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259362&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57418686 404339548 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822429 COc1ccc2ncc(-c3ccc(cc3)C(F)(F)F)n2n1 InChI=1S/C14H10F3N3O/c1-21-13-7-6-12-18-8-11(20(12)19-13)9-2-4-10(5-3-9)14(15,16)17/h2-8H,1H3 IVGVIXYZACDUMF-UHFFFAOYSA-N 50259329 CHEMBL4063254 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259329&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137635304 404339537 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822431 CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(n3)S(C)(=O)=O)n2n1 InChI=1S/C15H18N6O3S/c1-3-10(9-22)18-13-4-5-14-17-8-12(21(14)20-13)11-6-7-16-15(19-11)25(2,23)24/h4-8,10,22H,3,9H2,1-2H3,(H,18,20)/t10-/m0/s1 RWVARJSWZIIHSJ-JTQLQIEISA-N 50259525 CHEMBL4062683 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259525&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137635713 404339574 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822432 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(\C=N\O)c3)n2n1 InChI=1S/C17H19N5O2/c1-2-14(11-23)20-16-6-7-17-18-10-15(22(17)21-16)13-5-3-4-12(8-13)9-19-24/h3-10,14,23-24H,2,11H2,1H3,(H,20,21)/b19-9+/t14-/m0/s1 FTGAOPZDJRWUTG-FRSZACSASA-N 50259589 CHEMBL4065432 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137631656 404339591 C02658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953547 CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1 VUZOCQCFKZJNJC-YRQZNCJOSA-N 50256734 (-)-Cercosporamide::CHEMBL475816 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2018.05.044 10.7270/Q2G44SSP 29853332 Dao, VH; Ourliac-Garnier, I; Bazin, MA; Jacquot, C; Baratte, B; Ruchaud, S; Bach, S; Grovel, O; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256734&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90907011 104108099 CHEMBL475816 ZINC05114136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953556 NC(=O)c1c(O)cc(O)c2c3nc[nH]c(=O)c3oc12 InChI=1S/C11H7N3O5/c12-10(17)6-4(16)1-3(15)5-7-9(19-8(5)6)11(18)14-2-13-7/h1-2,15-16H,(H2,12,17)(H,13,14,18) PWJHRBPKGHHEDX-UHFFFAOYSA-N 50274762 CHEMBL4128587 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.05.044 10.7270/Q2G44SSP 29853332 Dao, VH; Ourliac-Garnier, I; Bazin, MA; Jacquot, C; Baratte, B; Ruchaud, S; Bach, S; Grovel, O; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274762&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145961986 405257008 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953557 NC(=O)c1c(O)cc(O)c2c1oc1c2[nH]c(=O)[nH]c1=O InChI=1S/C11H7N3O6/c12-9(17)5-3(16)1-2(15)4-6-8(20-7(4)5)10(18)14-11(19)13-6/h1,15-16H,(H2,12,17)(H2,13,14,18,19) TYTGUNDPUMJHPW-UHFFFAOYSA-N 50274742 CHEMBL4129279 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.05.044 10.7270/Q2G44SSP 29853332 Dao, VH; Ourliac-Garnier, I; Bazin, MA; Jacquot, C; Baratte, B; Ruchaud, S; Bach, S; Grovel, O; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274742&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145960511 405257006 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50953558 NC(=O)c1c(O)cc(O)c2c1oc1c(N)ncnc21 InChI=1S/C11H8N4O4/c12-10-9-7(14-2-15-10)5-3(16)1-4(17)6(11(13)18)8(5)19-9/h1-2,16-17H,(H2,13,18)(H2,12,14,15) YROMDBCZHPOCDZ-UHFFFAOYSA-N 50274761 CHEMBL4127885 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.05.044 10.7270/Q2G44SSP 29853332 Dao, VH; Ourliac-Garnier, I; Bazin, MA; Jacquot, C; Baratte, B; Ruchaud, S; Bach, S; Grovel, O; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274761&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145960449 405257007 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112053 CC(C)c1n[nH]c2c(NCc3ccccc3)nc(NC3CCC(N)CC3)nc12 InChI=1S/C21H29N7/c1-13(2)17-18-19(28-27-17)20(23-12-14-6-4-3-5-7-14)26-21(25-18)24-16-10-8-15(22)9-11-16/h3-7,13,15-16H,8-12,22H2,1-2H3,(H,27,28)(H2,23,24,25,26) XGFAWOAQXUCOCE-UHFFFAOYSA-N 50454184 CHEMBL4205015 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1900 ChEMBL 10.1016/j.bmc.2017.10.012 10.7270/Q25141T6 29273417 Cherukupalli, S; Hampannavar, GA; Chinnam, S; Chandrasekaran, B; Sayyad, N; Kayamba, F; Reddy Aleti, R; Karpoormath, R University of KwaZulu-Natal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454184&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49835655 433922568 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112065 CC(C)c1n[nH]c2c(NCc3ccccc3)nc(NC3CCCCC3N)nc12 InChI=1S/C21H29N7/c1-13(2)17-18-19(28-27-17)20(23-12-14-8-4-3-5-9-14)26-21(25-18)24-16-11-7-6-10-15(16)22/h3-5,8-9,13,15-16H,6-7,10-12,22H2,1-2H3,(H,27,28)(H2,23,24,25,26) NVTINYQXFHNHIJ-UHFFFAOYSA-N 50454182 CHEMBL4210771 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 ChEMBL 10.1016/j.bmc.2017.10.012 10.7270/Q25141T6 29273417 Cherukupalli, S; Hampannavar, GA; Chinnam, S; Chandrasekaran, B; Sayyad, N; Kayamba, F; Reddy Aleti, R; Karpoormath, R University of KwaZulu-Natal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454182&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 49793229 433922566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114678 Oc1ccc(cc1)-c1cnc2[nH]nc(NC(=O)CCCl)c2c1 InChI=1S/C15H13ClN4O2/c16-6-5-13(22)18-15-12-7-10(8-17-14(12)19-20-15)9-1-3-11(21)4-2-9/h1-4,7-8,21H,5-6H2,(H2,17,18,19,20,22) VCLXILPCPHUYCM-UHFFFAOYSA-N 50455458 CHEMBL4211730 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145965274 433923551 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114679 CCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccc(O)cc1 InChI=1S/C15H14N4O2/c1-2-13(21)17-15-12-7-10(8-16-14(12)18-19-15)9-3-5-11(20)6-4-9/h3-8,20H,2H2,1H3,(H2,16,17,18,19,21) BRRMXZJHBNJKLR-UHFFFAOYSA-N 50455459 CHEMBL4214475 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455459&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145972978 433923552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114680 CCCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccc(O)cc1 InChI=1S/C17H18N4O2/c1-2-3-4-15(23)19-17-14-9-12(10-18-16(14)20-21-17)11-5-7-13(22)8-6-11/h5-10,22H,2-4H2,1H3,(H2,18,19,20,21,23) BSKBQZJTXZVLBM-UHFFFAOYSA-N 50455460 CHEMBL4203594 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3500 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145975301 433923553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114681 O=C(Nc1n[nH]c2ncc(cc12)-c1cncnc1)C1CCCCC1 InChI=1S/C17H18N6O/c24-17(11-4-2-1-3-5-11)21-16-14-6-12(9-20-15(14)22-23-16)13-7-18-10-19-8-13/h6-11H,1-5H2,(H2,20,21,22,23,24) RJPUDBUEIKLQCU-UHFFFAOYSA-N 50455461 CHEMBL4208708 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455461&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145964690 433923554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114682 Oc1ccccc1-c1cnc2[nH]nc(NC(=O)C3CCCCC3)c2c1 InChI=1S/C19H20N4O2/c24-16-9-5-4-8-14(16)13-10-15-17(20-11-13)22-23-18(15)21-19(25)12-6-2-1-3-7-12/h4-5,8-12,24H,1-3,6-7H2,(H2,20,21,22,23,25) HBGIQICHLJLQQW-UHFFFAOYSA-N 50455462 CHEMBL4213114 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145966753 433923555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114685 Oc1ccc(cc1)-c1cnc2[nH]nc(NC(=O)C3CCCCC3)c2c1 InChI=1S/C19H20N4O2/c24-15-8-6-12(7-9-15)14-10-16-17(20-11-14)22-23-18(16)21-19(25)13-4-2-1-3-5-13/h6-11,13,24H,1-5H2,(H2,20,21,22,23,25) YIBBSHOOUHCPPP-UHFFFAOYSA-N 50455465 CHEMBL4217525 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10400 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455465&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973776 433923558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114687 Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)/b13-12+ AYZRKFOEZQBUEA-OUKQBFOZSA-N 50455463 CHEMBL215205 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135398514 433923556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51114689 CCC(CC)C(=O)Nc1n[nH]c2ncc(cc12)-c1ccc(O)cc1 InChI=1S/C18H20N4O2/c1-3-11(4-2)18(24)20-17-15-9-13(10-19-16(15)21-22-17)12-5-7-14(23)8-6-12/h5-11,23H,3-4H2,1-2H3,(H2,19,20,21,22,24) VWRJCJNRMRUFIS-UHFFFAOYSA-N 50455464 CHEMBL4216945 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 529300 ChEMBL 10.1016/j.bmcl.2018.02.054 10.7270/Q2MP55V8 29550093 Jing, L; Tang, Y; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455464&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145972145 433923557 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112884 COc1ccc(F)c(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H19F2N5O4S/c1-12-13(2)28-33-21(12)29-34(30,31)15-6-4-14(5-7-15)26-22-25-11-10-17(27-22)19-18(32-3)9-8-16(23)20(19)24/h4-11,29H,1-3H3,(H,25,26,27) FPPDWTSDSZADQO-UHFFFAOYSA-N 50454379 CHEMBL4205123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454379&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145975607 433922736 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112885 COc1cc(F)c(c(F)c1)-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H19F2N5O4S/c1-12-13(2)28-33-21(12)29-34(30,31)16-6-4-14(5-7-16)26-22-25-9-8-19(27-22)20-17(23)10-15(32-3)11-18(20)24/h4-11,29H,1-3H3,(H,25,26,27) ZFEUWTMEXIDLMB-UHFFFAOYSA-N 50454380 CHEMBL4216857 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454380&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145972371 433922737 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112886 COc1cccc(Cl)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20ClN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)16-9-7-15(8-10-16)25-22-24-12-11-18(26-22)20-17(23)5-4-6-19(20)31-3/h4-12,28H,1-3H3,(H,24,25,26) WCQPPPLDPGLXOK-UHFFFAOYSA-N 50454381 CHEMBL4216734 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454381&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145974213 433922738 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112887 CCOc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C21H19FN6O3S2/c1-3-31-19-12-14(22)4-9-17(19)18-10-11-23-20(25-18)24-15-5-7-16(8-6-15)33(29,30)28-21-27-26-13(2)32-21/h4-12H,3H2,1-2H3,(H,27,28)(H,23,24,25) ZMZIPHROZUBATK-UHFFFAOYSA-N 50454382 CHEMBL4206688 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454382&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145976910 433922739 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112888 COc1cc(F)ccc1-c1ccnc(Nc2cccc(Cn3cnc4ccccc34)c2)n1 InChI=1S/C25H20FN5O/c1-32-24-14-18(26)9-10-20(24)21-11-12-27-25(30-21)29-19-6-4-5-17(13-19)15-31-16-28-22-7-2-3-8-23(22)31/h2-14,16H,15H2,1H3,(H,27,29,30) HQVUAGCBAZOMFE-UHFFFAOYSA-N 50454383 CHEMBL4206359 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145975412 433922740 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112890 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H17FN6O3S2/c1-12-25-26-20(31-12)27-32(28,29)15-6-4-14(5-7-15)23-19-22-10-9-17(24-19)16-8-3-13(21)11-18(16)30-2/h3-11H,1-2H3,(H,26,27)(H,22,23,24) DNGLPAVFEOLFIO-UHFFFAOYSA-N 50454385 CHEMBL4218213 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454385&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145970759 433922742 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112891 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2noc3ccccc23)n1 InChI=1S/C24H18FN5O4S/c1-33-22-14-15(25)6-11-18(22)20-12-13-26-24(28-20)27-16-7-9-17(10-8-16)35(31,32)30-23-19-4-2-3-5-21(19)34-29-23/h2-14H,1H3,(H,29,30)(H,26,27,28) ZZIVLVSLTIYADD-UHFFFAOYSA-N 50454386 CHEMBL4205084 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454386&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145967972 433922743 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112892 COc1ccccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2noc(C)c2C)n1 InChI=1S/C22H21N5O4S/c1-14-15(2)31-26-21(14)27-32(28,29)17-10-8-16(9-11-17)24-22-23-13-12-19(25-22)18-6-4-5-7-20(18)30-3/h4-13H,1-3H3,(H,26,27)(H,23,24,25) XRANJRXEZLWYJP-UHFFFAOYSA-N 50454387 CHEMBL4216304 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454387&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145974441 433922744 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112893 Cc1noc(NS(=O)(=O)c2ccc(Nc3nccc(n3)-c3ccc(F)cc3Cl)cc2)c1C InChI=1S/C21H17ClFN5O3S/c1-12-13(2)27-31-20(12)28-32(29,30)16-6-4-15(5-7-16)25-21-24-10-9-19(26-21)17-8-3-14(23)11-18(17)22/h3-11,28H,1-2H3,(H,24,25,26) MPAQAURRGMTTKV-UHFFFAOYSA-N 50454388 CHEMBL4218452 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454388&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145969623 433922745 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112894 Cc1noc(NS(=O)(=O)c2ccc(Nc3nccc(n3)-c3ccc(F)cc3F)cc2)c1C InChI=1S/C21H17F2N5O3S/c1-12-13(2)27-31-20(12)28-32(29,30)16-6-4-15(5-7-16)25-21-24-10-9-19(26-21)17-8-3-14(22)11-18(17)23/h3-11,28H,1-2H3,(H,24,25,26) SWSRKLYGLXMTAH-UHFFFAOYSA-N 50454389 CHEMBL4216726 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454389&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973744 433922746 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112895 CSc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20FN5O3S2/c1-13-14(2)27-31-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-9-4-15(23)12-20(18)32-3/h4-12,28H,1-3H3,(H,24,25,26) CGJSARMCXCGGCW-UHFFFAOYSA-N 50454390 CHEMBL4215592 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454390&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973475 433922747 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112896 CCOc1cc(Cl)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C23H22ClN5O4S/c1-4-32-21-13-16(24)5-10-19(21)20-11-12-25-23(27-20)26-17-6-8-18(9-7-17)34(30,31)29-22-14(2)15(3)28-33-22/h5-13,29H,4H2,1-3H3,(H,25,26,27) FKCFTFILSPYLMY-UHFFFAOYSA-N 50454391 CHEMBL4204994 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145978289 433922748 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112897 CCOc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C23H22FN5O4S/c1-4-32-20-7-5-6-18(24)21(20)19-12-13-25-23(27-19)26-16-8-10-17(11-9-16)34(30,31)29-22-14(2)15(3)28-33-22/h5-13,29H,4H2,1-3H3,(H,25,26,27) BFSKFHZFACZLER-UHFFFAOYSA-N 50454392 CHEMBL4204526 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454392&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977821 433922749 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112898 CCOc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C23H22FN5O4S/c1-4-32-21-13-16(24)5-10-19(21)20-11-12-25-23(27-20)26-17-6-8-18(9-7-17)34(30,31)29-22-14(2)15(3)28-33-22/h5-13,29H,4H2,1-3H3,(H,25,26,27) MFGPPACYEFGSTK-UHFFFAOYSA-N 50454393 CHEMBL4216190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145972813 433922750 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112899 COc1cc(Cl)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20ClN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-9-4-15(23)12-20(18)31-3/h4-12,28H,1-3H3,(H,24,25,26) MECDFEWXMIUNSU-UHFFFAOYSA-N 50454394 CHEMBL4205921 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454394&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977120 433922751 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112900 COc1cc(F)c(F)cc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H19F2N5O4S/c1-12-13(2)28-33-21(12)29-34(30,31)15-6-4-14(5-7-15)26-22-25-9-8-19(27-22)16-10-17(23)18(24)11-20(16)32-3/h4-11,29H,1-3H3,(H,25,26,27) ZVLFDFWFDUVCGU-UHFFFAOYSA-N 50454395 CHEMBL4203989 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454395&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145975562 433922752 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112901 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-9-4-15(23)12-20(18)31-3/h4-12,28H,1-3H3,(H,24,25,26) AJXDBLPSUPQKBJ-UHFFFAOYSA-N 50454396 CHEMBL4207754 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454396&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145976701 433922753 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112902 COc1ccccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H21N5O4S/c1-14-15(2)26-31-21(14)27-32(28,29)17-10-8-16(9-11-17)24-22-23-13-12-19(25-22)18-6-4-5-7-20(18)30-3/h4-13,27H,1-3H3,(H,23,24,25) CUCBJZSGNZBKEE-UHFFFAOYSA-N 50454397 CHEMBL4215514 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145974162 433922754 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112903 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)C(O)=O)n1 InChI=1S/C18H14FN3O3/c1-25-16-10-12(19)4-7-14(16)15-8-9-20-18(22-15)21-13-5-2-11(3-6-13)17(23)24/h2-10H,1H3,(H,23,24)(H,20,21,22) REBRCFSKMUTQDS-UHFFFAOYSA-N 50454398 CHEMBL4203836 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454398&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977291 433922755 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112904 COc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)n1 InChI=1S/C20H16FN5O3S2/c1-29-17-4-2-3-15(21)18(17)16-9-10-22-19(25-16)24-13-5-7-14(8-6-13)31(27,28)26-20-23-11-12-30-20/h2-12H,1H3,(H,23,26)(H,22,24,25) BQRWVMGYVBRTGW-UHFFFAOYSA-N 50454399 CHEMBL4215419 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454399&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973930 433922756 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112905 CCOc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)n1 InChI=1S/C21H18FN5O3S2/c1-2-30-19-13-14(22)3-8-17(19)18-9-10-23-20(26-18)25-15-4-6-16(7-5-15)32(28,29)27-21-24-11-12-31-21/h3-13H,2H2,1H3,(H,24,27)(H,23,25,26) OFFZTZQPFQQGKB-UHFFFAOYSA-N 50454400 CHEMBL4216039 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454400&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973951 433922757 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112906 COc1ccccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H18N6O3S2/c1-13-24-25-20(30-13)26-31(27,28)15-9-7-14(8-10-15)22-19-21-12-11-17(23-19)16-5-3-4-6-18(16)29-2/h3-12H,1-2H3,(H,25,26)(H,21,22,23) OBMIDCIHJHNZFZ-UHFFFAOYSA-N 50454401 CHEMBL4202527 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454401&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145976229 433922758 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112907 COc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H17FN6O3S2/c1-12-25-26-20(31-12)27-32(28,29)14-8-6-13(7-9-14)23-19-22-11-10-16(24-19)18-15(21)4-3-5-17(18)30-2/h3-11H,1-2H3,(H,26,27)(H,22,23,24) LRXZVWVFJCSXSV-UHFFFAOYSA-N 50454402 CHEMBL4209357 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145965423 433922759 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112908 COc1cc(F)c(F)cc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H16F2N6O3S2/c1-11-26-27-20(32-11)28-33(29,30)13-5-3-12(4-6-13)24-19-23-8-7-17(25-19)14-9-15(21)16(22)10-18(14)31-2/h3-10H,1-2H3,(H,27,28)(H,23,24,25) WBEAFTGSPZEEIR-UHFFFAOYSA-N 50454403 CHEMBL4210799 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145966399 433922760 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112909 CCOc1cc(Cl)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C21H19ClN6O3S2/c1-3-31-19-12-14(22)4-9-17(19)18-10-11-23-20(25-18)24-15-5-7-16(8-6-15)33(29,30)28-21-27-26-13(2)32-21/h4-12H,3H2,1-2H3,(H,27,28)(H,23,24,25) MLTGOCWSTUBXGD-UHFFFAOYSA-N 50454404 CHEMBL4209987 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145965913 433922761 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112910 COc1cc(F)c(Nc2nccc(n2)-c2ccc(F)cc2OC)cc1C(N)=O InChI=1S/C19H16F2N4O3/c1-27-16-7-10(20)3-4-11(16)14-5-6-23-19(24-14)25-15-8-12(18(22)26)17(28-2)9-13(15)21/h3-9H,1-2H3,(H2,22,26)(H,23,24,25) WNQPHLAUPBBBFU-UHFFFAOYSA-N 50454405 CHEMBL4207380 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454405&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977187 433922762 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112911 COc1cccc(F)c1-c1ccnc(Nc2cc(C(N)=O)c(OC)cc2F)n1 InChI=1S/C19H16F2N4O3/c1-27-15-5-3-4-11(20)17(15)13-6-7-23-19(24-13)25-14-8-10(18(22)26)16(28-2)9-12(14)21/h3-9H,1-2H3,(H2,22,26)(H,23,24,25) HHCOUYYRWHXUAC-UHFFFAOYSA-N 50454406 CHEMBL4213102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145966261 433922763 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112912 CCOc1cc(F)ccc1-c1ccnc(Nc2cc(C(N)=O)c(OC)cc2F)n1 InChI=1S/C20H18F2N4O3/c1-3-29-18-8-11(21)4-5-12(18)15-6-7-24-20(25-15)26-16-9-13(19(23)27)17(28-2)10-14(16)22/h4-10H,3H2,1-2H3,(H2,23,27)(H,24,25,26) QEVPCFCNOLNUJL-UHFFFAOYSA-N 50454407 CHEMBL4214607 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145974842 433922764 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112913 CCOc1cc(Cl)ccc1-c1ccnc(Nc2cc(C(N)=O)c(OC)cc2F)n1 InChI=1S/C20H18ClFN4O3/c1-3-29-18-8-11(21)4-5-12(18)15-6-7-24-20(25-15)26-16-9-13(19(23)27)17(28-2)10-14(16)22/h4-10H,3H2,1-2H3,(H2,23,27)(H,24,25,26) CKUHEEMBETZXOQ-UHFFFAOYSA-N 50454408 CHEMBL4217886 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145974763 433922765 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112914 COc1cc(F)c(Nc2nccc(n2)-c2ccc(F)cc2F)cc1C(N)=O InChI=1S/C18H13F3N4O2/c1-27-16-8-13(21)15(7-11(16)17(22)26)25-18-23-5-4-14(24-18)10-3-2-9(19)6-12(10)20/h2-8H,1H3,(H2,22,26)(H,23,24,25) DGVJWXLMYXXGHA-UHFFFAOYSA-N 50454409 CHEMBL4215321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454409&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973693 433922766 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112915 COc1cccc(F)c1-c1ccnc(Nc2cccc(Cn3cnc4ccccc34)c2)n1 InChI=1S/C25H20FN5O/c1-32-23-11-5-8-19(26)24(23)21-12-13-27-25(30-21)29-18-7-4-6-17(14-18)15-31-16-28-20-9-2-3-10-22(20)31/h2-14,16H,15H2,1H3,(H,27,29,30) MDOPSPOMDXUNGM-UHFFFAOYSA-N 50454410 CHEMBL4212641 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145965313 433922767 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112921 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112922 CC(C)Oc1cccc(-c2ccnc(Nc3ccc(cc3)S(=O)(=O)Nc3onc(C)c3C)n2)c1F InChI=1S/C24H24FN5O4S/c1-14(2)33-21-7-5-6-19(22(21)25)20-12-13-26-24(28-20)27-17-8-10-18(11-9-17)35(31,32)30-23-15(3)16(4)29-34-23/h5-14,30H,1-4H3,(H,26,27,28) HTWRNSUAXNIUCQ-UHFFFAOYSA-N 50454428 CHEMBL4211689 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 458 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454428&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145967175 433922769 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112923 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)C(=O)Nc2onc(C)c2C)n1 InChI=1S/C23H20FN5O3/c1-13-14(2)29-32-22(13)28-21(30)15-4-7-17(8-5-15)26-23-25-11-10-19(27-23)18-9-6-16(24)12-20(18)31-3/h4-12H,1-3H3,(H,28,30)(H,25,26,27) DGGRGPAHRNGGGK-UHFFFAOYSA-N 50454439 CHEMBL4206205 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 135 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454439&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977131 433922770 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112924 COc1ccc(F)cc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H17FN6O3S2/c1-12-25-26-20(31-12)27-32(28,29)15-6-4-14(5-7-15)23-19-22-10-9-17(24-19)16-11-13(21)3-8-18(16)30-2/h3-11H,1-2H3,(H,26,27)(H,22,23,24) OWQKUKUKXLQRLY-UHFFFAOYSA-N 50454440 CHEMBL4217685 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454440&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145973338 433922771 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112925 COc1ccccc1-c1ccnc(Nc2cccc(Cn3cnc4ccccc34)c2)n1 InChI=1S/C25H21N5O/c1-31-24-12-5-2-9-20(24)21-13-14-26-25(29-21)28-19-8-6-7-18(15-19)16-30-17-27-22-10-3-4-11-23(22)30/h2-15,17H,16H2,1H3,(H,26,28,29) ZNYWIWXWOHYBON-UHFFFAOYSA-N 50454384 CHEMBL4205779 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454384&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145975632 433922741 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112927 COc1ccc(F)c(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H16F2N6O3S2/c1-11-26-27-20(32-11)28-33(29,30)13-5-3-12(4-6-13)24-19-23-10-9-15(25-19)17-16(31-2)8-7-14(21)18(17)22/h3-10H,1-2H3,(H,27,28)(H,23,24,25) XWXGKRQCUJICNZ-UHFFFAOYSA-N 50454441 CHEMBL4217448 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.400000 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454441&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145972872 433922772 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112928 COc1ccccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)n1 InChI=1S/C20H17N5O3S2/c1-28-18-5-3-2-4-16(18)17-10-11-21-19(24-17)23-14-6-8-15(9-7-14)30(26,27)25-20-22-12-13-29-20/h2-13H,1H3,(H,22,25)(H,21,23,24) LNRMRFAGLGEVBC-UHFFFAOYSA-N 50454442 CHEMBL4204402 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454442&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145976565 433922773 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112929 Cc1noc(NS(=O)(=O)c2ccc(Nc3nccc(n3)-c3ccc(Cl)cc3Cl)cc2)c1C InChI=1S/C21H17Cl2N5O3S/c1-12-13(2)27-31-20(12)28-32(29,30)16-6-4-15(5-7-16)25-21-24-10-9-19(26-21)17-8-3-14(22)11-18(17)23/h3-11,28H,1-2H3,(H,24,25,26) LVQNVBAEMYBEOA-UHFFFAOYSA-N 50454443 CHEMBL4204120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454443&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977047 433922774 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112930 CC(C)Oc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C24H24FN5O4S/c1-14(2)33-22-13-17(25)5-10-20(22)21-11-12-26-24(28-21)27-18-6-8-19(9-7-18)35(31,32)30-23-15(3)16(4)29-34-23/h5-14,30H,1-4H3,(H,26,27,28) JELDXXKXSFSHOQ-UHFFFAOYSA-N 50454444 CHEMBL4208684 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454444&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145963783 433922775 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112931 COc1ccc(c(OC)c1)-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C23H23N5O5S/c1-14-15(2)27-33-22(14)28-34(29,30)18-8-5-16(6-9-18)25-23-24-12-11-20(26-23)19-10-7-17(31-3)13-21(19)32-4/h5-13,28H,1-4H3,(H,24,25,26) CUCSXQCVIUDKLI-UHFFFAOYSA-N 50454445 CHEMBL4203392 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145978465 433922776 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112932 COc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)16-9-7-15(8-10-16)25-22-24-12-11-18(26-22)20-17(23)5-4-6-19(20)31-3/h4-12,28H,1-3H3,(H,24,25,26) CIKHZDKMTDPCLM-UHFFFAOYSA-N 50454411 CHEMBL4209151 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454411&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145964931 433922768 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112933 COc1cc(F)ccc1-c1cc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)ncn1 InChI=1S/C22H20FN5O4S/c1-13-14(2)27-32-22(13)28-33(29,30)17-7-5-16(6-8-17)26-21-11-19(24-12-25-21)18-9-4-15(23)10-20(18)31-3/h4-12,28H,1-3H3,(H,24,25,26) HOLLEZFBSXELQT-UHFFFAOYSA-N 50454446 CHEMBL4209469 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 76901385 433922777 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112934 CCOc1cc(Cl)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)n1 InChI=1S/C21H18ClN5O3S2/c1-2-30-19-13-14(22)3-8-17(19)18-9-10-23-20(26-18)25-15-4-6-16(7-5-15)32(28,29)27-21-24-11-12-31-21/h3-13H,2H2,1H3,(H,24,27)(H,23,25,26) VGAJDLUOYXTTRJ-UHFFFAOYSA-N 50454447 CHEMBL4215880 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 378 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454447&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145971368 433922778 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112935 COc1ccc(c(OC)c1)-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C21H20N6O4S2/c1-13-25-26-21(32-13)27-33(28,29)16-7-4-14(5-8-16)23-20-22-11-10-18(24-20)17-9-6-15(30-2)12-19(17)31-3/h4-12H,1-3H3,(H,26,27)(H,22,23,24) WKDOKJKUKSSFSB-UHFFFAOYSA-N 50454449 CHEMBL4211337 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145966185 433922779 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112936 COc1cc(F)c(Nc2nccc(n2)-c2cc(F)c(F)cc2OC)cc1C(N)=O InChI=1S/C19H15F3N4O3/c1-28-16-7-12(21)11(20)5-9(16)14-3-4-24-19(25-14)26-15-6-10(18(23)27)17(29-2)8-13(15)22/h3-8H,1-2H3,(H2,23,27)(H,24,25,26) NTMUINUAJVCMDH-UHFFFAOYSA-N 50454450 CHEMBL4207215 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454450&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145977923 433922780 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112937 COc1cc(F)c(Nc2nccc(n2)-c2ccc(F)cc2OC(C)C)cc1C(N)=O InChI=1S/C21H20F2N4O3/c1-11(2)30-19-8-12(22)4-5-13(19)16-6-7-25-21(26-16)27-17-9-14(20(24)28)18(29-3)10-15(17)23/h4-11H,1-3H3,(H2,24,28)(H,25,26,27) HWXHRSCEACQBKJ-UHFFFAOYSA-N 50454452 CHEMBL4212016 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454452&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145966214 433922781 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112940 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)n1 InChI=1S/C20H16FN5O3S2/c1-29-18-12-13(21)2-7-16(18)17-8-9-22-19(25-17)24-14-3-5-15(6-4-14)31(27,28)26-20-23-10-11-30-20/h2-12H,1H3,(H,23,26)(H,22,24,25) ORCMTKOVGLGATH-UHFFFAOYSA-N 50454454 CHEMBL4209102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 122 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145966577 433922783 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112941 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2noc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)32-27-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-9-4-15(23)12-20(18)31-3/h4-12H,1-3H3,(H,27,28)(H,24,25,26) PEFQLFPPRNGLJD-UHFFFAOYSA-N 50454453 CHEMBL4211020 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454453&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145964106 433922782 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112942 COc1ccccc1-c1ccnc(Nc2cc(C(N)=O)c(OC)cc2F)n1 InChI=1S/C19H17FN4O3/c1-26-16-6-4-3-5-11(16)14-7-8-22-19(23-14)24-15-9-12(18(21)25)17(27-2)10-13(15)20/h3-10H,1-2H3,(H2,21,25)(H,22,23,24) AGVKMSHAHBUJMI-UHFFFAOYSA-N 50454455 CHEMBL4206833 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1576 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454455&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145978593 433922784 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112943 Cc1noc(NS(=O)(=O)c2ccc(Nc3nccc(n3)-c3ccc(F)cc3C)cc2)c1C InChI=1S/C22H20FN5O3S/c1-13-12-16(23)4-9-19(13)20-10-11-24-22(26-20)25-17-5-7-18(8-6-17)32(29,30)28-21-14(2)15(3)27-31-21/h4-12,28H,1-3H3,(H,24,25,26) XYWHOWNTZXFAKW-UHFFFAOYSA-N 50454456 CHEMBL4213505 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145963970 433922785 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112944 COc1ccc(F)cc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-12-15(23)4-9-20(18)31-3/h4-12,28H,1-3H3,(H,24,25,26) ZBJGREHWROGYRW-UHFFFAOYSA-N 50454457 CHEMBL4203224 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454457&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145976257 433922786 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51112945 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)-c2c(C)noc2C)n1 InChI=1S/C22H19FN4O2/c1-13-21(14(2)29-27-13)15-4-7-17(8-5-15)25-22-24-11-10-19(26-22)18-9-6-16(23)12-20(18)28-3/h4-12H,1-3H3,(H,24,25,26) DITJTRMRKAMYBI-UHFFFAOYSA-N 50454458 CHEMBL4208916 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145965855 433922787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098797 Cn1c(cccc1=O)-c1ccc(cc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1 InChI=1S/C32H32N6O2/c1-37-29(8-5-9-31(37)39)25-11-15-27(16-12-25)38(32(40)35-21-23-6-3-2-4-7-23)28-17-13-26(14-18-28)36-30-19-10-24(20-33)22-34-30/h2-12,15-16,19,22,26,28H,13-14,17-18,21H2,1H3,(H,34,36)(H,35,40)/t26-,28- CEXGJBJPUFDWAH-FBSWEULCSA-N 50367679 CHEMBL4164064 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367679&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145957794 160846781 ZINC48998273 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098804 Cn1cc(ccc1=O)-c1ccc(cc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1 InChI=1S/C32H32N6O2/c1-37-22-26(10-18-31(37)39)25-8-13-28(14-9-25)38(32(40)35-20-23-5-3-2-4-6-23)29-15-11-27(12-16-29)36-30-17-7-24(19-33)21-34-30/h2-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,1H3,(H,34,36)(H,35,40)/t27-,29- HDJBGURZVALLMD-KWQFAZJVSA-N 50367676 CHEMBL4160662 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367676&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134813906 160846778 ZINC49774918 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098816 CC(C)C(=O)OC[C@@H]1O[C@H]([C@@H](O)[C@@H]1O)n1cnc(N)c2c(C(N)=O)c(Br)nc12 InChI=1S/C16H20BrN5O6/c1-5(2)16(26)27-3-6-9(23)10(24)15(28-6)22-4-20-12(18)8-7(13(19)25)11(17)21-14(8)22/h4-6,9-10,15,23-24H,3,18H2,1-2H3,(H2,19,25)/t6-,9+,10-,15+/m0/s1 FECJFYFWBIAIIL-WYLSKWGASA-N 50367682 CHEMBL4162128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367682&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145958217 160846784 ZINC49049619 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098821 Cn1cc(cn1)-c1ccc(cc1)N([C@@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1 InChI=1S/C30H31N7O/c1-36-21-25(20-34-36)24-8-12-27(13-9-24)37(30(38)33-18-22-5-3-2-4-6-22)28-14-10-26(11-15-28)35-29-16-7-23(17-31)19-32-29/h2-9,12-13,16,19-21,26,28H,10-11,14-15,18H2,1H3,(H,32,35)(H,33,38)/t26-,28+ KHMZQQYEYPDOBI-DBAYTGFXSA-N 50367849 CHEMBL4175774 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367849&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145950134 160846951 ZINC22064534 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098825 Cn1cc(cn1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ccc(cn1)C#N InChI=1S/C21H22N6O2S/c1-26-15-18(14-24-26)17-3-5-20(6-4-17)30(28,29)27-10-8-19(9-11-27)25-21-7-2-16(12-22)13-23-21/h2-7,13-15,19H,8-11H2,1H3,(H,23,25) MBFRPRCYZAVISU-UHFFFAOYSA-N 50367737 CHEMBL4173631 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367737&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145951220 160846839 ZINC04433167 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098846 Cn1cc(cn1)-c1ccc(cc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1 InChI=1S/C30H31N7O/c1-36-21-25(20-34-36)24-8-12-27(13-9-24)37(30(38)33-18-22-5-3-2-4-6-22)28-14-10-26(11-15-28)35-29-16-7-23(17-31)19-32-29/h2-9,12-13,16,19-21,26,28H,10-11,14-15,18H2,1H3,(H,32,35)(H,33,38)/t26-,28- KHMZQQYEYPDOBI-FBSWEULCSA-N 50367845 CHEMBL4173254 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367845&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145950134 160846947 ZINC48998291 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098854 O=C(NCc1ccccc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)c1ccccc1 InChI=1S/C26H27N5O/c27-17-21-11-16-25(28-19-21)30-22-12-14-24(15-13-22)31(23-9-5-2-6-10-23)26(32)29-18-20-7-3-1-4-8-20/h1-11,16,19,22,24H,12-15,18H2,(H,28,30)(H,29,32)/t22-,24- VCNSLPOQKMCPOO-HCGLCNNCSA-N 50367707 CHEMBL4167916 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367707&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145952973 160846809 ZINC11686200 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098855 O=C(NCc1ccccc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)c1ccc(cc1)-c1cccnc1 InChI=1S/C31H30N6O/c32-19-24-8-17-30(34-21-24)36-27-11-15-29(16-12-27)37(31(38)35-20-23-5-2-1-3-6-23)28-13-9-25(10-14-28)26-7-4-18-33-22-26/h1-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,(H,34,36)(H,35,38)/t27-,29- QQIVUNFCAOZJSD-KWQFAZJVSA-N 50367685 CHEMBL4172363 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367685&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145952248 160846787 ZINC48998517 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098856 Cn1cccc(-c2ccc(cc2)N([C@H]2CC[C@@H](CC2)Nc2ccc(cn2)C#N)C(=O)NCc2ccccc2)c1=O InChI=1S/C32H32N6O2/c1-37-19-5-8-29(31(37)39)25-10-14-27(15-11-25)38(32(40)35-21-23-6-3-2-4-7-23)28-16-12-26(13-17-28)36-30-18-9-24(20-33)22-34-30/h2-11,14-15,18-19,22,26,28H,12-13,16-17,21H2,1H3,(H,34,36)(H,35,40)/t26-,28- ZULSMIQPZXUJHT-FBSWEULCSA-N 50367854 CHEMBL4164483 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367854&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145959803 160846956 ZINC49771802 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098860 Cn1ccc(cc1=O)-c1ccc(cc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1 InChI=1S/C32H32N6O2/c1-37-18-17-26(19-31(37)39)25-8-12-28(13-9-25)38(32(40)35-21-23-5-3-2-4-6-23)29-14-10-27(11-15-29)36-30-16-7-24(20-33)22-34-30/h2-9,12-13,16-19,22,27,29H,10-11,14-15,21H2,1H3,(H,34,36)(H,35,40)/t27-,29- GXGRNWVRDQTYLG-KWQFAZJVSA-N 50367957 CHEMBL4174715 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145949983 160847059 ZINC03777968 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51098864 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1021/acs.jmedchem.8b00683 10.7270/Q2HX1G6F 30067358 Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51101314 OC(=O)c1nc2ccccc2nc1Nc1cccc(O)c1 InChI=1S/C15H11N3O3/c19-10-5-3-4-9(8-10)16-14-13(15(20)21)17-11-6-1-2-7-12(11)18-14/h1-8,19H,(H,16,18)(H,20,21) BGYMHNWAGXBGBJ-UHFFFAOYSA-N 50406883 CHEMBL4177432 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.04.056 10.7270/Q2HM5C0X 29778892 Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C University of Tours http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50406883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50406883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145972012 163355907 ZINC13832473 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51101322 OC(=O)c1nc2ccccc2nc1Nc1cccc(c1)N1CCOCC1 InChI=1S/C19H18N4O3/c24-19(25)17-18(22-16-7-2-1-6-15(16)21-17)20-13-4-3-5-14(12-13)23-8-10-26-11-9-23/h1-7,12H,8-11H2,(H,20,22)(H,24,25) HDXVVXPARDDJNW-UHFFFAOYSA-N 50406885 CHEMBL4170635 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.04.056 10.7270/Q2HM5C0X 29778892 Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C University of Tours http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50406885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50406885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145951743 163355909 ZINC13832477 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51101328 [K+].Nc1cccc(Nc2nc3ccccc3nc2C([O-])=O)c1 InChI=1S/C15H12N4O2/c16-9-4-3-5-10(8-9)17-14-13(15(20)21)18-11-6-1-2-7-12(11)19-14/h1-8H,16H2,(H,17,19)(H,20,21)/p-1 DWGDWPYHHSGLRS-UHFFFAOYSA-M 50406879 CHEMBL4174068 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.04.056 10.7270/Q2HM5C0X 29778892 Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C University of Tours http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50406879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50406879&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145951035 163355903 ZINC13832401 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51101341 OC(=O)c1nc2ccccc2nc1Nc1ccc(O)cc1 InChI=1S/C15H11N3O3/c19-10-7-5-9(6-8-10)16-14-13(15(20)21)17-11-3-1-2-4-12(11)18-14/h1-8,19H,(H,16,18)(H,20,21) OVFXYHHZLWWAJN-UHFFFAOYSA-N 50406891 CHEMBL4163110 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.04.056 10.7270/Q2HM5C0X 29778892 Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C University of Tours http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50406891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50406891&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145958016 163355915 ZINC13832480 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51101350 OC(=O)c1nc2ccccc2nc1Nc1ccccc1O InChI=1S/C15H11N3O3/c19-12-8-4-3-7-11(12)18-14-13(15(20)21)16-9-5-1-2-6-10(9)17-14/h1-8,19H,(H,17,18)(H,20,21) XVRFKJJGGJBRMI-UHFFFAOYSA-N 50406882 CHEMBL4166554 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.04.056 10.7270/Q2HM5C0X 29778892 Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C University of Tours http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50406882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50406882&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145953574 163355906 ZINC13832417 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128888 Cn1cc(C2=C(C(=O)N(O)C2=O)c2c[nH]c3ccccc23)c2ccccc12 InChI=1S/C21H15N3O3/c1-23-11-15(13-7-3-5-9-17(13)23)19-18(20(25)24(27)21(19)26)14-10-22-16-8-4-2-6-12(14)16/h2-11,22,27H,1H3 RGFGSHDWFCMDPT-UHFFFAOYSA-N 50463027 CHEMBL4242235 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463027&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145983031 433930292 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128910 ON1C(=O)C(=C(C1=O)c1c[nH]c2ncccc12)c1c[nH]c2ccccc12 InChI=1S/C19H12N4O3/c24-18-15(12-8-21-14-6-2-1-4-10(12)14)16(19(25)23(18)26)13-9-22-17-11(13)5-3-7-20-17/h1-9,21,26H,(H,20,22) AKXUZWMUYIYFBC-UHFFFAOYSA-N 50463025 CHEMBL4238093 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463025&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145983454 433930290 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128911 CC(C)n1cc(C2=C(C(=O)N(O)C2=O)c2cn(C)c3ccccc23)c2ccccc12 InChI=1S/C24H21N3O3/c1-14(2)26-13-18(16-9-5-7-11-20(16)26)22-21(23(28)27(30)24(22)29)17-12-25(3)19-10-6-4-8-15(17)19/h4-14,30H,1-3H3 DQMTUDZOBTYFRY-UHFFFAOYSA-N 50463030 CHEMBL4239321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463030&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145985214 433930295 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128919 CC(C)n1cc(C2=C(C(=O)N(O)C2=O)c2c[nH]c3ccccc23)c2ccccc12 InChI=1S/C23H19N3O3/c1-13(2)25-12-17(15-8-4-6-10-19(15)25)21-20(22(27)26(29)23(21)28)16-11-24-18-9-5-3-7-14(16)18/h3-13,24,29H,1-2H3 QRULFZAODSXOSD-UHFFFAOYSA-N 50463031 CHEMBL4249393 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463031&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145982872 433930296 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128992 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ncccc23)c2ccccc12 InChI=1S/C21H16N4O2/c1-24-10-14(12-6-3-4-8-16(12)24)17-18(21(27)23-20(17)26)15-11-25(2)19-13(15)7-5-9-22-19/h3-11H,1-2H3,(H,23,26,27) XGISVNPAZQTTIQ-UHFFFAOYSA-N 2605 (Arylindolyl)maleimide deriv. 27::3-(1-methyl-1H-indol-3-yl)-4-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}-2,5-dihydro-1H-pyrrole-2,5-dione Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2605&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5327669 8032375 ZINC13447728 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128993 CCn1cc(C2=C(C(=O)N(O)C2=O)c2cn(C)c3ccccc23)c2ccccc12 InChI=1S/C23H19N3O3/c1-3-25-13-17(15-9-5-7-11-19(15)25)21-20(22(27)26(29)23(21)28)16-12-24(2)18-10-6-4-8-14(16)18/h4-13,29H,3H2,1-2H3 ZHLFBWBIXCAZOI-UHFFFAOYSA-N 50463036 CHEMBL4246062 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463036&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145983820 433930301 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128994 Cn1cc(C2=C(C(=O)N(O)C2=O)c2cn(CCCCCC#N)c3ccccc23)c2ccccc12 InChI=1S/C27H24N4O3/c1-29-16-20(18-10-4-6-12-22(18)29)24-25(27(33)31(34)26(24)32)21-17-30(15-9-3-2-8-14-28)23-13-7-5-11-19(21)23/h4-7,10-13,16-17,34H,2-3,8-9,15H2,1H3 XHCPBAACWOBIQV-UHFFFAOYSA-N 50463035 CHEMBL4245590 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2100 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463035&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145985058 433930300 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128995 Cn1cc(C2=C(C(=O)N(O)C2=O)c2cn(CCCCCC(O)=O)c3ccccc23)c2ccccc12 InChI=1S/C27H25N3O5/c1-28-15-19(17-9-4-6-11-21(17)28)24-25(27(34)30(35)26(24)33)20-16-29(14-8-2-3-13-23(31)32)22-12-7-5-10-18(20)22/h4-7,9-12,15-16,35H,2-3,8,13-14H2,1H3,(H,31,32) IEKFVXRUVOKBHO-UHFFFAOYSA-N 50463026 CHEMBL4240779 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 700 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463026&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145985465 433930291 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128996 CCn1cc(C2=C(C(=O)N(O)C2=O)c2cn(C(C)C)c3ccccc23)c2ccccc12 InChI=1S/C25H23N3O3/c1-4-26-13-18(16-9-5-7-11-20(16)26)22-23(25(30)28(31)24(22)29)19-14-27(15(2)3)21-12-8-6-10-17(19)21/h5-15,31H,4H2,1-3H3 VGMGHXKQJJEULT-UHFFFAOYSA-N 50463028 CHEMBL4238883 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 700 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463028&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145982985 433930293 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128997 ON1C(=O)C2=C(C1=O)c1cn(CCCCCCn3cc2c2ccccc32)c2ccccc12 InChI=1S/C26H23N3O3/c30-25-23-19-15-27(21-11-5-3-9-17(19)21)13-7-1-2-8-14-28-16-20(24(23)26(31)29(25)32)18-10-4-6-12-22(18)28/h3-6,9-12,15-16,32H,1-2,7-8,13-14H2 DSFLQDSPXCKHCF-UHFFFAOYSA-N 50463032 CHEMBL4243080 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463032&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145982789 433930297 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51128998 O=C1NC(=O)C(=C1c1cn(CCCCCC#N)c2ccccc12)c1cn(CCCCCC#N)c2ccccc12 InChI=1S/C32H31N5O2/c33-17-9-1-3-11-19-36-21-25(23-13-5-7-15-27(23)36)29-30(32(39)35-31(29)38)26-22-37(20-12-4-2-10-18-34)28-16-8-6-14-24(26)28/h5-8,13-16,21-22H,1-4,9-12,19-20H2,(H,35,38,39) QAMBUGZDXYEHNV-UHFFFAOYSA-N 50463034 CHEMBL4238971 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 420 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463034&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145984202 433930299 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51129003 ON1C(=O)C(=C(C1=O)c1cn(CCCCCC(O)=O)c2ccccc12)c1c[nH]c2ccccc12 InChI=1S/C26H23N3O5/c30-22(31)12-2-1-7-13-28-15-19(17-9-4-6-11-21(17)28)24-23(25(32)29(34)26(24)33)18-14-27-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,27,34H,1-2,7,12-13H2,(H,30,31) YAPCPBJABJHWRU-UHFFFAOYSA-N 50463024 CHEMBL4241699 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463024&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145982552 433930289 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51129010 Cn1cc(C2=C(C(=O)N(O)C2=O)c2cn(C)c3ccccc23)c2ccccc12 InChI=1S/C22H17N3O3/c1-23-11-15(13-7-3-5-9-17(13)23)19-20(22(27)25(28)21(19)26)16-12-24(2)18-10-6-4-8-14(16)18/h3-12,28H,1-2H3 FXMSIIWIRRECIQ-UHFFFAOYSA-N 50463029 CHEMBL4241803 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463029&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145984001 433930294 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51129023 ON1C(=O)C(=C(C1=O)c1cn(CCCCCC#N)c2ccccc12)c1cn(CCCCCC#N)c2ccccc12 InChI=1S/C32H31N5O3/c33-17-9-1-3-11-19-35-21-25(23-13-5-7-15-27(23)35)29-30(32(39)37(40)31(29)38)26-22-36(20-12-4-2-10-18-34)28-16-8-6-14-24(26)28/h5-8,13-16,21-22,40H,1-4,9-12,19-20H2 PKJLRWOISVLKLH-UHFFFAOYSA-N 50463033 CHEMBL4244860 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2018.07.012 10.7270/Q270843T 30026041 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO University College Cork http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463033&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145983553 433930298 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51038378 CCN1CCC(CC1)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C30H36F2N8/c1-5-38-11-8-22(9-12-38)39-13-10-25-20(17-39)6-7-27(35-25)36-30-33-16-24(32)28(37-30)21-14-23(31)29-26(15-21)40(18(2)3)19(4)34-29/h6-7,14-16,18,22H,5,8-13,17H2,1-4H3,(H,33,35,36,37) AUIRGOWAROZXCR-UHFFFAOYSA-N 50458024 CHEMBL4203179 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 ChEMBL 10.1016/j.ejmech.2018.02.022 10.7270/Q2154KNQ 29459274 Zha, C; Deng, W; Fu, Y; Tang, S; Lan, X; Ye, Y; Su, Y; Jiang, L; Chen, Y; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutical, Co. Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458024&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124114343 433925289 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51038435 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 57 ChEMBL 10.1016/j.ejmech.2018.02.022 10.7270/Q2154KNQ 29459274 Zha, C; Deng, W; Fu, Y; Tang, S; Lan, X; Ye, Y; Su, Y; Jiang, L; Chen, Y; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutical, Co. Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51137079 COCCN[C@H]1CC[C@@H](CC1)Nc1cc(-c2csc(NCC3(CCOCC3)C#N)n2)c(Cl)cn1 InChI=1S/C24H33ClN6O2S/c1-32-11-8-27-17-2-4-18(5-3-17)30-22-12-19(20(25)13-28-22)21-14-34-23(31-21)29-16-24(15-26)6-9-33-10-7-24/h12-14,17-18,27H,2-11,16H2,1H3,(H,28,30)(H,29,31)/t17-,18- XSDZPPRQLIZLDG-IYARVYRRSA-N 50466210 CHEMBL4281048 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1016/j.ejmech.2018.09.025 10.7270/Q2DJ5J9D 30253346 Wang, B; Wu, J; Wu, Y; Chen, C; Zou, F; Wang, A; Wu, H; Hu, Z; Jiang, Z; Liu, Q; Wang, W; Zhang, Y; Liu, F; Zhao, M; Hu, J; Huang, T; Ge, J; Wang, L; Ren, T; Wang, Y; Liu, J; Liu, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134814484 433933475 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50839678 Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3cccc(Cl)c3)ncnc12 InChI=1S/C23H22ClN7O/c1-14-4-2-7-19(29-14)23(32)30-17-9-18(10-17)31-13-28-20-21(26-12-27-22(20)31)25-11-15-5-3-6-16(24)8-15/h2-8,12-13,17-18H,9-11H2,1H3,(H,30,32)(H,25,26,27)/t17-,18+ GGRVRRFOVWKWMD-HDICACEKSA-N 50261164 CHEMBL4103221 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2017.08.018 10.7270/Q2W66P60 28827110 Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261164&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137657453 404340625 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50839687 Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3cccc(Br)c3)ncnc12 InChI=1S/C23H22BrN7O/c1-14-4-2-7-19(29-14)23(32)30-17-9-18(10-17)31-13-28-20-21(26-12-27-22(20)31)25-11-15-5-3-6-16(24)8-15/h2-8,12-13,17-18H,9-11H2,1H3,(H,30,32)(H,25,26,27)/t17-,18+ QYLYUTQSYHCBOD-HDICACEKSA-N 50261163 CHEMBL4081756 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2017.08.018 10.7270/Q2W66P60 28827110 Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261163&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137646454 404340624 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822583 CC[C@@H](CO)Nc1ccc2ncc(-c3ccc(cc3)C(F)(F)F)n2n1 InChI=1S/C17H17F3N4O/c1-2-13(10-25)22-15-7-8-16-21-9-14(24(16)23-15)11-3-5-12(6-4-11)17(18,19)20/h3-9,13,25H,2,10H2,1H3,(H,22,23)/t13-/m0/s1 IZURDRXMCYDUFB-ZDUSSCGKSA-N 50259523 CHEMBL4104296 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7500 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259523&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137658150 404339572 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822597 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(c3)S(C)(=O)=O)n2n1 InChI=1S/C17H20N4O3S/c1-3-13(11-22)19-16-7-8-17-18-10-15(21(17)20-16)12-5-4-6-14(9-12)25(2,23)24/h4-10,13,22H,3,11H2,1-2H3,(H,19,20)/t13-/m0/s1 RVNDFXJEYCICIV-ZDUSSCGKSA-N 50259467 CHEMBL4070189 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259467&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137638472 104109752 ZINC42834209 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822633 CC[C@@H](CO)Nc1ccc2ncc(-c3cc4ccccc4[nH]3)n2n1 InChI=1S/C18H19N5O/c1-2-13(11-24)20-17-7-8-18-19-10-16(23(18)22-17)15-9-12-5-3-4-6-14(12)21-15/h3-10,13,21,24H,2,11H2,1H3,(H,20,22)/t13-/m0/s1 CQZSVQKINMHLBO-ZDUSSCGKSA-N 50259409 CHEMBL4062820 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259409&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137634382 404339555 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822635 CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(SC)n3)n2n1 InChI=1S/C15H18N6OS/c1-3-10(9-22)18-13-4-5-14-17-8-12(21(14)20-13)11-6-7-16-15(19-11)23-2/h4-8,10,22H,3,9H2,1-2H3,(H,18,20)/t10-/m0/s1 HHTIJHCFCZBRNC-JTQLQIEISA-N 50259474 CHEMBL4092047 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259474&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137653446 404339563 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822636 COc1ccc2ncc(-c3cccc(\C=N\O)c3)n2n1 InChI=1S/C14H12N4O2/c1-20-14-6-5-13-15-9-12(18(13)17-14)11-4-2-3-10(7-11)8-16-19/h2-9,19H,1H3/b16-8+ UTDNMHFLZJFPPY-LZYBPNLTSA-N 50259335 CHEMBL4072506 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2200 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259335&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137640038 404339540 C02658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822827 CC[C@@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@@H](CC)CO)nn12 InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m0/s1 KCXBBJNHGRCSQQ-IRXDYDNUSA-N 50259543 CHEMBL4071413 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137638944 404339577 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822829 CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 KCXBBJNHGRCSQQ-IAGOWNOFSA-N 50259572 CHEMBL4076663 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137650926 404339587 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822831 COc1ccc2ncc(\C=C\c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C16H12F3N3O/c1-23-15-8-7-14-20-10-13(22(14)21-15)6-5-11-3-2-4-12(9-11)16(17,18)19/h2-10H,1H3/b6-5+ JNNGGJDFTJICDZ-AATRIKPKSA-N 50259562 CHEMBL4091127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137644974 404339584 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822846 FC(F)(F)c1cccc(c1)-c1cnc2ccc(Cl)nn12 InChI=1S/C13H7ClF3N3/c14-11-4-5-12-18-7-10(20(12)19-11)8-2-1-3-9(6-8)13(15,16)17/h1-7H FABGVXWXZKTQBP-UHFFFAOYSA-N 50259358 CHEMBL4070065 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259358&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 59379853 404339544 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822975 CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(Cl)nn12 InChI=1S/C17H17ClN4O2/c1-2-13(10-23)20-17(24)12-5-3-4-11(8-12)14-9-19-16-7-6-15(18)21-22(14)16/h3-9,13,23H,2,10H2,1H3,(H,20,24)/t13-/m1/s1 DPVHKRYDZPCZCT-CYBMUJFWSA-N 50259520 CHEMBL4075820 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137650421 404339570 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822978 Nc1ccc(Cl)cc1-c1cnc2ccc(Cl)nn12 InChI=1S/C12H8Cl2N4/c13-7-1-2-9(15)8(5-7)10-6-16-12-4-3-11(14)17-18(10)12/h1-6H,15H2 XDTSBZLQROEIPM-UHFFFAOYSA-N 50259519 CHEMBL4087260 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137643887 404339569 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822983 CC[C@@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17+/m1/s1 KCXBBJNHGRCSQQ-SJORKVTESA-N 50259588 CHEMBL4079343 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137651538 404339590 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50822988 COc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 InChI=1S/C15H12N4O/c1-20-15-5-4-14-17-9-13(19(14)18-15)11-2-3-12-10(8-11)6-7-16-12/h2-9,16H,1H3 HTNKXRHQVGPWRO-UHFFFAOYSA-N 50259319 CHEMBL4079347 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259319&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137651314 404339534 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823536 Nc1cccc(c1)-c1cnc2ccc(Cl)nn12 InChI=1S/C12H9ClN4/c13-11-4-5-12-15-7-10(17(12)16-11)8-2-1-3-9(14)6-8/h1-7H,14H2 QPIYTIVQAQQCFP-UHFFFAOYSA-N 50259363 CHEMBL4089542 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7300 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259363&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 58857683 404339549 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823548 CSc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C14H10F3N3S/c1-21-13-6-5-12-18-8-11(20(12)19-13)9-3-2-4-10(7-9)14(15,16)17/h2-8H,1H3 YJKLTUUIJIUZDP-UHFFFAOYSA-N 50259355 CHEMBL4069158 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259355&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137631819 404339542 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860732 CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3/t12-,14+/m1/s1 QLUYMIVVAYRECT-OCCSQVGLSA-N 50193086 CHEMBL3969723 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 23643976 375076096 CHEMBL3969723 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860738 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1ccccc1F)cc2=O InChI=1S/C23H22FNO5/c1-25-9-8-15(20(29)12-25)21-18(27)11-19(28)22-17(26)10-14(30-23(21)22)7-6-13-4-2-3-5-16(13)24/h2-7,10-11,15,20,27-29H,8-9,12H2,1H3/b7-6+/t15-,20+/m0/s1 WPVJHWMAIWTPQH-WZHKBMRHSA-N 50263030 CHEMBL4094775 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 260 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263030&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137655446 104111527 ZINC40917887 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860754 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(C)cc2=O InChI=1S/C16H19NO5/c1-8-5-10(18)15-12(20)6-11(19)14(16(15)22-8)9-3-4-17(2)7-13(9)21/h5-6,9,13,19-21H,3-4,7H2,1-2H3/t9-,13+/m0/s1 MOCVYVBNJQIVOV-TVQRCGJNSA-N 50189885 Rohitukine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50189885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50189885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 13422573 346535251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860755 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(F)c(F)c(F)c(F)c1F)cc2=O InChI=1S/C23H18F5NO5/c1-29-5-4-10(15(33)8-29)16-13(31)7-14(32)17-12(30)6-9(34-23(16)17)2-3-11-18(24)20(26)22(28)21(27)19(11)25/h2-3,6-7,10,15,31-33H,4-5,8H2,1H3/b3-2+/t10-,15+/m0/s1 DGSZFJJTBGMXJM-FLPPUKGPSA-N 50263041 CHEMBL4103469 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263041&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137657189 404341351 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860757 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1cccc(Cl)c1)cc2=O InChI=1S/C23H22ClNO5/c1-25-8-7-16(20(29)12-25)21-18(27)11-19(28)22-17(26)10-15(30-23(21)22)6-5-13-3-2-4-14(24)9-13/h2-6,9-11,16,20,27-29H,7-8,12H2,1H3/b6-5+/t16-,20+/m0/s1 FLRKPLFPBHNFLM-UUHFFZMRSA-N 50263012 CHEMBL4065874 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263012&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137632049 404341347 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860775 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c3ccccc3cc3ccccc13)cc2=O InChI=1S/C31H27NO5/c1-32-13-12-24(28(36)17-32)29-26(34)16-27(35)30-25(33)15-20(37-31(29)30)10-11-23-21-8-4-2-6-18(21)14-19-7-3-5-9-22(19)23/h2-11,14-16,24,28,34-36H,12-13,17H2,1H3/b11-10+/t24-,28+/m0/s1 TYEGPOQQLDRKLM-CBANFVEMSA-N 50263014 CHEMBL4087077 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263014&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137643609 404341349 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860778 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1ccccc1)cc2=O InChI=1S/C23H23NO5/c1-24-10-9-16(20(28)13-24)21-18(26)12-19(27)22-17(25)11-15(29-23(21)22)8-7-14-5-3-2-4-6-14/h2-8,11-12,16,20,26-28H,9-10,13H2,1H3/b8-7+/t16-,20+/m0/s1 NNBNTVQDBZQPFA-KJOHCHSBSA-N 50263011 CHEMBL4100359 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 66 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263011&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137660052 404341346 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785557 C(Cc1c[nH]c2ccccc12)Nc1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C21H18N6/c1-2-6-18-15(4-1)14(12-25-18)7-10-23-21-24-11-8-19(27-21)17-13-26-20-16(17)5-3-9-22-20/h1-6,8-9,11-13,25H,7,10H2,(H,22,26)(H,23,24,27) NCXCJSWWOBAQCH-UHFFFAOYSA-N 50250830 CHEMBL4090021 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250830&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137644929 401962443 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785558 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cc2ccccc2s1 InChI=1S/C19H13N5S/c20-19-21-6-5-15(24-19)14-10-23-18-13(14)7-12(9-22-18)17-8-11-3-1-2-4-16(11)25-17/h1-10H,(H,22,23)(H2,20,21,24) AJQWHEHMQASSNJ-UHFFFAOYSA-N 50250836 CHEMBL4063190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250836&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206995 401962449 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785560 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1ccsc1 InChI=1S/C15H11N5S/c16-15-17-3-1-13(20-15)12-7-19-14-11(12)5-10(6-18-14)9-2-4-21-8-9/h1-8H,(H,18,19)(H2,16,17,20) XXQVLOPILTZOES-UHFFFAOYSA-N 50250824 CHEMBL4101278 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250824&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137661231 401962437 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785566 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccnc1 InChI=1S/C16H12N6/c17-16-19-5-3-14(22-16)13-9-21-15-12(13)6-11(8-20-15)10-2-1-4-18-7-10/h1-9H,(H,20,21)(H2,17,19,22) QXLMUZJTNLPDOC-UHFFFAOYSA-N 50250825 CHEMBL4074567 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250825&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206992 401962438 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785567 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1ccc(F)cc1 InChI=1S/C17H12FN5/c18-12-3-1-10(2-4-12)11-7-13-14(9-22-16(13)21-8-11)15-5-6-20-17(19)23-15/h1-9H,(H,21,22)(H2,19,20,23) GJYYBRPTBQFCBQ-UHFFFAOYSA-N 50250813 CHEMBL4095226 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250813&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206982 401962426 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785571 COc1ccc(cc1)-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C18H15N5O/c1-24-13-4-2-11(3-5-13)12-8-14-15(10-22-17(14)21-9-12)16-6-7-20-18(19)23-16/h2-10H,1H3,(H,21,22)(H2,19,20,23) UAOPMXFMGZKQAZ-UHFFFAOYSA-N 50250816 CHEMBL4097680 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250816&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206345 401962429 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785577 COc1ccc(CCNc2nccc(n2)-c2c[nH]c3ncccc23)cc1OC InChI=1S/C21H21N5O2/c1-27-18-6-5-14(12-19(18)28-2)7-10-23-21-24-11-8-17(26-21)16-13-25-20-15(16)4-3-9-22-20/h3-6,8-9,11-13H,7,10H2,1-2H3,(H,22,25)(H,23,24,26) QBZJXRZGTAPTRK-UHFFFAOYSA-N 50250829 CHEMBL4090926 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 59 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250829&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137644723 401962442 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785583 COc1ccnc2[nH]cc(-c3ccnc(N)n3)c12 InChI=1S/C12H11N5O/c1-18-9-3-5-14-11-10(9)7(6-16-11)8-2-4-15-12(13)17-8/h2-6H,1H3,(H,14,16)(H2,13,15,17) GGEWEQJWGGJUHO-UHFFFAOYSA-N 50371402 MERIOLIN 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search MFR 3BHT,7A5B 23727981 160850503 DB08178 ZINC16052675 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785584 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cc2ccccc2o1 InChI=1S/C19H13N5O/c20-19-21-6-5-15(24-19)14-10-23-18-13(14)7-12(9-22-18)17-8-11-3-1-2-4-16(11)25-17/h1-10H,(H,22,23)(H2,20,21,24) FAMCONSWGPBLET-UHFFFAOYSA-N 50250826 CHEMBL4084840 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250826&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137647543 401962439 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785586 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1ccoc1 InChI=1S/C15H11N5O/c16-15-17-3-1-13(20-15)12-7-19-14-11(12)5-10(6-18-14)9-2-4-21-8-9/h1-8H,(H,18,19)(H2,16,17,20) XVSQCPXHQMSQEO-UHFFFAOYSA-N 50250823 CHEMBL4065940 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250823&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206993 401962436 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785590 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C18H12F3N5O/c19-18(20,21)27-12-3-1-10(2-4-12)11-7-13-14(9-25-16(13)24-8-11)15-5-6-23-17(22)26-15/h1-9H,(H,24,25)(H2,22,23,26) WRJVXZDHOXZXQE-UHFFFAOYSA-N 50250814 CHEMBL4068858 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250814&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129207000 401962427 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785591 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)C(F)(F)F InChI=1S/C18H12F3N5/c19-18(20,21)12-3-1-10(2-4-12)11-7-13-14(9-25-16(13)24-8-11)15-5-6-23-17(22)26-15/h1-9H,(H,24,25)(H2,22,23,26) AJXGHWYKQWIXBJ-UHFFFAOYSA-N 50250812 CHEMBL4067806 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250812&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206884 401962425 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785593 CSc1ccccc1-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C18H15N5S/c1-24-16-5-3-2-4-12(16)11-8-13-14(10-22-17(13)21-9-11)15-6-7-20-18(19)23-15/h2-10H,1H3,(H,21,22)(H2,19,20,23) GNJFUEMVZYQNNS-UHFFFAOYSA-N 50250834 CHEMBL4095974 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250834&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206983 401962447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785598 CSc1ccc(cc1)-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C18H15N5S/c1-24-13-4-2-11(3-5-13)12-8-14-15(10-22-17(14)21-9-12)16-6-7-20-18(19)23-16/h2-10H,1H3,(H,21,22)(H2,19,20,23) OHZVXKQYXMVYBA-UHFFFAOYSA-N 50250817 CHEMBL4079646 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206291 401962430 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785599 C1CN(CCO1)c1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C15H15N5O/c1-2-11-12(10-18-14(11)16-4-1)13-3-5-17-15(19-13)20-6-8-21-9-7-20/h1-5,10H,6-9H2,(H,16,18) WBZBMAXVQDWVAX-UHFFFAOYSA-N 50250832 CHEMBL4060268 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 642 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250832&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137634496 401962445 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785601 C1CCN(CC1)c1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C16H17N5/c1-2-9-21(10-3-1)16-18-8-6-14(20-16)13-11-19-15-12(13)5-4-7-17-15/h4-8,11H,1-3,9-10H2,(H,17,19) UMPRPWIMIXAZFO-UHFFFAOYSA-N 50250831 CHEMBL4082174 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 800 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250831&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 90765738 401962444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785602 Nc1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C11H9N5/c12-11-14-5-3-9(16-11)8-6-15-10-7(8)2-1-4-13-10/h1-6H,(H,13,15)(H2,12,14,16) HQHSJJZIICGOIX-UHFFFAOYSA-N 50371404 MERIOLIN 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11637090 160850505 ZINC29135178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785607 C1CCN(C1)c1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C15H15N5/c1-2-9-20(8-1)15-17-7-5-13(19-15)12-10-18-14-11(12)4-3-6-16-14/h3-7,10H,1-2,8-9H2,(H,16,18) YUICVGMWAHXZED-UHFFFAOYSA-N 50250838 CHEMBL4068940 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250838&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137632536 401962451 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785614 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(F)c1 InChI=1S/C17H12FN5/c18-12-3-1-2-10(6-12)11-7-13-14(9-22-16(13)21-8-11)15-4-5-20-17(19)23-15/h1-9H,(H,21,22)(H2,19,20,23) FZHFVGHEAYFGKQ-UHFFFAOYSA-N 50250819 CHEMBL4071557 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250819&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206999 401962432 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785616 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)C(F)(F)F InChI=1S/C18H12F3N5/c19-18(20,21)12-3-1-2-10(6-12)11-7-13-14(9-25-16(13)24-8-11)15-4-5-23-17(22)26-15/h1-9H,(H,24,25)(H2,22,23,26) XTBUCBOROGHGGY-UHFFFAOYSA-N 50250820 CHEMBL4077931 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250820&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206866 401962433 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785619 COc1ccc2ccccc2c1-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C22H17N5O/c1-28-19-7-6-13-4-2-3-5-15(13)20(19)14-10-16-17(12-26-21(16)25-11-14)18-8-9-24-22(23)27-18/h2-12H,1H3,(H,25,26)(H2,23,24,27) OAVFWONTXQVCLK-UHFFFAOYSA-N 50250835 CHEMBL4093541 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 625 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250835&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137656331 401962448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785623 Cc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C18H15N5/c1-11-3-2-4-12(7-11)13-8-14-15(10-22-17(14)21-9-13)16-5-6-20-18(19)23-16/h2-10H,1H3,(H,21,22)(H2,19,20,23) YPKNDOKDJMTLHJ-UHFFFAOYSA-N 50250818 CHEMBL4098589 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 146 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206994 401962431 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785624 CCc1ccccc1-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C19H17N5/c1-2-12-5-3-4-6-14(12)13-9-15-16(11-23-18(15)22-10-13)17-7-8-21-19(20)24-17/h3-11H,2H2,1H3,(H,22,23)(H2,20,21,24) MKQHKMLZVXCNPR-UHFFFAOYSA-N 50250821 CHEMBL4085794 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 213 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250821&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206868 401962434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785635 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.7 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785638 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc2ccccc12 InChI=1S/C21H15N5/c22-21-23-9-8-19(26-21)18-12-25-20-17(18)10-14(11-24-20)16-7-3-5-13-4-1-2-6-15(13)16/h1-12H,(H,24,25)(H2,22,23,26) KMDAPIILFLZFRB-UHFFFAOYSA-N 50250822 CHEMBL4103720 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 159 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250822&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206998 401962435 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785639 Nc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1ccc(Cl)cc1 InChI=1S/C17H12ClN5/c18-12-3-1-10(2-4-12)11-7-13-14(9-22-16(13)21-8-11)15-5-6-20-17(19)23-15/h1-9H,(H,21,22)(H2,19,20,23) GJHHGLCAFGSVNF-UHFFFAOYSA-N 50250815 CHEMBL4089950 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250815&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206987 401962428 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785640 CN1CCN(CC1)c1nccc(n1)-c1c[nH]c2ncccc12 InChI=1S/C16H18N6/c1-21-7-9-22(10-8-21)16-18-6-4-14(20-16)13-11-19-15-12(13)3-2-5-17-15/h2-6,11H,7-10H2,1H3,(H,17,19) DJBOWTBDWVSNIU-UHFFFAOYSA-N 50250833 CHEMBL4105467 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 700 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250833&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137656839 401962446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785641 COc1ccc2[nH]c(cc2c1)-c1cnc2[nH]cc(-c3ccnc(N)n3)c2c1 InChI=1S/C20H16N6O/c1-27-13-2-3-16-11(6-13)8-18(25-16)12-7-14-15(10-24-19(14)23-9-12)17-4-5-22-20(21)26-17/h2-10,25H,1H3,(H,23,24)(H2,21,22,26) XBCKUDPRGSZKAN-UHFFFAOYSA-N 50250827 CHEMBL4071643 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 342 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250827&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129206869 401962440 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50785656 COc1ccc(CCNc2nccc(n2)-c2c[nH]c3ncccc23)cc1 InChI=1S/C20H19N5O/c1-26-15-6-4-14(5-7-15)8-11-22-20-23-12-9-18(25-20)17-13-24-19-16(17)3-2-10-21-19/h2-7,9-10,12-13H,8,11H2,1H3,(H,21,24)(H,22,23,25) CMQDHVBSNXSEQY-UHFFFAOYSA-N 50250837 CHEMBL4063017 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38 ChEMBL 10.1021/acs.jmedchem.7b00663 10.7270/Q2WH2SDH 29144137 Singh, U; Chashoo, G; Khan, SU; Mahajan, P; Nargotra, A; Mahajan, G; Singh, A; Sharma, A; Mintoo, MJ; Guru, SK; Aruri, H; Thatikonda, T; Sahu, P; Chibber, P; Kumar, V; Mir, SA; Bharate, SS; Madishetti, S; Nandi, U; Singh, G; Mondhe, DM; Bhushan, S; Malik, F; Mignani, S; Vishwakarma, RA; Singh, PP CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250837&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137636220 401962450 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823553 FC(F)(F)c1ccc(cc1)-c1cnc2ccc(Cl)nn12 InChI=1S/C13H7ClF3N3/c14-11-5-6-12-18-7-10(20(12)19-11)8-1-3-9(4-2-8)13(15,16)17/h1-7H RUXUZBIASAPEFP-UHFFFAOYSA-N 50259407 CHEMBL4085467 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89429109 404339553 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823555 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 InChI=1S/C16H17ClN4O/c1-2-13(10-22)19-15-6-7-16-18-9-14(21(16)20-15)11-4-3-5-12(17)8-11/h3-9,13,22H,2,10H2,1H3,(H,19,20)/t13-/m0/s1 KAGWQDFFFLWBFD-ZDUSSCGKSA-N 50259413 CHEMBL4105084 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259413&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137658187 404339559 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823556 CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)c1 InChI=1S/C20H16ClN5O/c1-13(27)23-16-6-3-7-17(11-16)24-19-8-9-20-22-12-18(26(20)25-19)14-4-2-5-15(21)10-14/h2-12H,1H3,(H,23,27)(H,24,25) AINKQRBPBUTJRM-UHFFFAOYSA-N 50259569 CHEMBL4074499 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137640934 104109832 ZINC03982130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823928 Fc1ccc2ncc(-c3cccc(C=O)c3)n2n1 InChI=1S/C13H8FN3O/c14-12-4-5-13-15-7-11(17(13)16-12)10-3-1-2-9(6-10)8-18/h1-8H WSIMQBVAVXJVGA-UHFFFAOYSA-N 50259326 CHEMBL4081668 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259326&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137646673 404339535 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823945 CC[C@@H](CO)Nc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 InChI=1S/C18H19N5O/c1-2-14(11-24)21-17-5-6-18-20-10-16(23(18)22-17)13-3-4-15-12(9-13)7-8-19-15/h3-10,14,19,24H,2,11H2,1H3,(H,21,22)/t14-/m0/s1 HMMICWRUNSZYCJ-AWEZNQCLSA-N 50259408 CHEMBL4090770 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2800 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137644498 404339554 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823947 CC[C@@H](CO)N(C(C)=O)c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 InChI=1S/C20H23N5O3/c1-4-17(12-26)24(14(3)28)20-9-8-19-21-11-18(25(19)23-20)15-6-5-7-16(10-15)22-13(2)27/h5-11,17,26H,4,12H2,1-3H3,(H,22,27)/t17-/m0/s1 YELPLVUUDHOICI-KRWDZBQOSA-N 50259561 CHEMBL4092673 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3500 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137653000 404339583 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823949 CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(n3)[S+](C)[O-])n2n1 InChI=1S/C15H18N6O2S/c1-3-10(9-22)18-13-4-5-14-17-8-12(21(14)20-13)11-6-7-16-15(19-11)24(2)23/h4-8,10,22H,3,9H2,1-2H3,(H,18,20)/t10-,24?/m0/s1 MQUIMJBWAKAKBG-CPMYVITQSA-N 50259475 CHEMBL4071234 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259475&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137638065 404339564 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50823951 CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(N)n3)n2n1 InChI=1S/C14H17N7O/c1-2-9(8-22)18-12-3-4-13-17-7-11(21(13)20-12)10-5-6-16-14(15)19-10/h3-7,9,22H,2,8H2,1H3,(H,18,20)(H2,15,16,19)/t9-/m0/s1 FJAIARRQBXWUMX-VIFPVBQESA-N 50259476 CHEMBL4084364 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2200 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259476&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137645650 404339565 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824150 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 InChI=1S/C18H21N5O2/c1-3-14(11-24)21-17-7-8-18-19-10-16(23(18)22-17)13-5-4-6-15(9-13)20-12(2)25/h4-10,14,24H,3,11H2,1-2H3,(H,20,25)(H,21,22)/t14-/m0/s1 YGXHQYJKJUFSJI-AWEZNQCLSA-N 50259415 CHEMBL4061526 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 800 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259415&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137635926 404339561 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824152 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(SC)c3)n2n1 InChI=1S/C17H20N4OS/c1-3-13(11-22)19-16-7-8-17-18-10-15(21(17)20-16)12-5-4-6-14(9-12)23-2/h4-10,13,22H,3,11H2,1-2H3,(H,19,20)/t13-/m0/s1 LZRHAZRGHSSHLR-ZDUSSCGKSA-N 50259416 CHEMBL4089652 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259416&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137643721 404339562 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824153 CC[C@@H](CO)Nc1ccc2ncc(-c3cc4cc(Br)ccc4[nH]3)n2n1 InChI=1S/C18H18BrN5O/c1-2-13(10-25)21-17-5-6-18-20-9-16(24(18)23-17)15-8-11-7-12(19)3-4-14(11)22-15/h3-9,13,22,25H,2,10H2,1H3,(H,21,23)/t13-/m0/s1 QQCCFMCJVKPTMI-ZDUSSCGKSA-N 50259521 CHEMBL4082981 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137646497 404339571 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824154 CC[C@H](CO)Nc1ccc2ncc(-c3cccc(\C=N\[C@H](CC)CO)c3)n2n1 InChI=1S/C21H27N5O2/c1-3-17(13-27)22-11-15-6-5-7-16(10-15)19-12-23-21-9-8-20(25-26(19)21)24-18(4-2)14-28/h5-12,17-18,27-28H,3-4,13-14H2,1-2H3,(H,24,25)/b22-11+/t17-,18-/m1/s1 SZOYOCHRMSEEMG-HFRLZFEPSA-N 50259571 CHEMBL4084919 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1300 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137647335 404339586 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824174 CC[C@@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(Cl)nn12 InChI=1S/C17H17ClN4O2/c1-2-13(10-23)20-17(24)12-5-3-4-11(8-12)14-9-19-16-7-6-15(18)21-22(14)16/h3-9,13,23H,2,10H2,1H3,(H,20,24)/t13-/m0/s1 DPVHKRYDZPCZCT-ZDUSSCGKSA-N 50259406 CHEMBL4093231 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137654225 404339552 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824175 CC[C@@H](CO)Nc1ccc2ncc(\C=C\c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C19H19F3N4O/c1-2-15(12-27)24-17-8-9-18-23-11-16(26(18)25-17)7-6-13-4-3-5-14(10-13)19(20,21)22/h3-11,15,27H,2,12H2,1H3,(H,24,25)/b7-6+/t15-/m0/s1 GWGKDCYRVAQDDJ-LFAOLKIESA-N 50259412 CHEMBL4080844 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3700 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137645947 404339558 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824234 CCOC(=O)c1cccc(c1)-c1cnc2ccc(N[C@@H](CC)CO)nn12 InChI=1S/C19H22N4O3/c1-3-15(12-24)21-17-8-9-18-20-11-16(23(18)22-17)13-6-5-7-14(10-13)19(25)26-4-2/h5-11,15,24H,3-4,12H2,1-2H3,(H,21,22)/t15-/m0/s1 DSCUTYQYWCTFQL-HNNXBMFYSA-N 50259477 CHEMBL4071322 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259477&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137638509 404339566 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824246 O\N=C\c1cccc(c1)-c1cnc2ccc(Cl)nn12 InChI=1S/C13H9ClN4O/c14-12-4-5-13-15-8-11(18(13)17-12)10-3-1-2-9(6-10)7-16-19/h1-8,19H/b16-7+ WSUWIXYPBRLNOT-FRKPEAEDSA-N 50259405 CHEMBL4077159 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259405&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137649318 404339551 C02658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824312 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(N)c3)n2n1 InChI=1S/C16H19N5O/c1-2-13(10-22)19-15-6-7-16-18-9-14(21(16)20-15)11-4-3-5-12(17)8-11/h3-9,13,22H,2,10,17H2,1H3,(H,19,20)/t13-/m0/s1 PSHWYQXGQNRHHK-ZDUSSCGKSA-N 50259414 CHEMBL4088717 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3800 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259414&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137643955 404339560 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824647 Clc1ccc2ncc(-c3cccnc3)n2n1 InChI=1S/C11H7ClN4/c12-10-3-4-11-14-7-9(16(11)15-10)8-2-1-5-13-6-8/h1-7H FFYSXJWQSSBECR-UHFFFAOYSA-N 50259361 CHEMBL4076906 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259361&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 45141513 404339547 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824652 CC[C@@H](CO)Nc1ccc2ncc(-c3cc(Cl)ccc3N)n2n1 InChI=1S/C16H18ClN5O/c1-2-11(9-23)20-15-5-6-16-19-8-14(22(16)21-15)12-7-10(17)3-4-13(12)18/h3-8,11,23H,2,9,18H2,1H3,(H,20,21)/t11-/m0/s1 DKGZXXQSVKWPRW-NSHDSACASA-N 50259524 CHEMBL4067477 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3400 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259524&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137633419 404339573 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824887 CCOC(=O)Nc1ccc2ncc(-c3cccnc3)n2n1 InChI=1S/C14H13N5O2/c1-2-21-14(20)17-12-5-6-13-16-9-11(19(13)18-12)10-4-3-7-15-8-10/h3-9H,2H2,1H3,(H,17,18,20) CEIVAPWZRJLAEW-UHFFFAOYSA-N 50259556 CHEMBL4083948 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137647969 404339579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824990 CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@@H](CC)CO)nn12 InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17+/m0/s1 KCXBBJNHGRCSQQ-DLBZAZTESA-N 50259587 CHEMBL4098237 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137659239 404339589 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50824991 CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C=O)c3)n2n1 InChI=1S/C17H18N4O2/c1-2-14(11-23)19-16-6-7-17-18-9-15(21(17)20-16)13-5-3-4-12(8-13)10-22/h3-10,14,23H,2,11H2,1H3,(H,19,20)/t14-/m0/s1 OHARPIGKJAKOCM-AWEZNQCLSA-N 50259526 CHEMBL4093104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 580 ChEMBL 10.1016/j.ejmech.2016.09.064 10.7270/Q2M61NPG 27721154 Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259526&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137655848 404339575 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860968 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1cccc(F)c1)cc2=O InChI=1S/C23H22FNO5/c1-25-8-7-16(20(29)12-25)21-18(27)11-19(28)22-17(26)10-15(30-23(21)22)6-5-13-3-2-4-14(24)9-13/h2-6,9-11,16,20,27-29H,7-8,12H2,1H3/b6-5+/t16-,20+/m0/s1 PZXBPUJVINVNLU-UUHFFZMRSA-N 50263027 CHEMBL4066369 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263027&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137632999 104111524 ZINC40917926 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860971 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(Cl)cccc1Cl)cc2=O InChI=1S/C23H21Cl2NO5/c1-26-8-7-14(20(30)11-26)21-18(28)10-19(29)22-17(27)9-12(31-23(21)22)5-6-13-15(24)3-2-4-16(13)25/h2-6,9-10,14,20,28-30H,7-8,11H2,1H3/b6-5+/t14-,20+/m0/s1 NFTJDXGFOUFNKG-UGBNQVSOSA-N 50263013 CHEMBL4079206 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.9 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263013&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137628639 404341348 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860974 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1ccc(Cl)cc1)cc2=O InChI=1S/C23H22ClNO5/c1-25-9-8-16(20(29)12-25)21-18(27)11-19(28)22-17(26)10-15(30-23(21)22)7-4-13-2-5-14(24)6-3-13/h2-7,10-11,16,20,27-29H,8-9,12H2,1H3/b7-4+/t16-,20+/m0/s1 GDIQYNLNVFYZFH-FCKNSPPLSA-N 50263031 CHEMBL4105395 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 310 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263031&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137657398 404341350 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860982 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1ccccc1Cl)cc2=O InChI=1S/C23H22ClNO5/c1-25-9-8-15(20(29)12-25)21-18(27)11-19(28)22-17(26)10-14(30-23(21)22)7-6-13-4-2-3-5-16(13)24/h2-7,10-11,15,20,27-29H,8-9,12H2,1H3/b7-6+/t15-,20+/m0/s1 GBRGVCGOKJCFLO-WZHKBMRHSA-N 50263045 CHEMBL4074270 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 160 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263045&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137641300 404341352 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50860985 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51139055 CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnn2ccc(C3CCOCC3)c12 InChI=1S/C23H34N6O2/c1-17(30)27-10-12-28(13-11-27)20-4-2-19(3-5-20)26-23-22-21(18-7-14-31-15-8-18)6-9-29(22)25-16-24-23/h6,9,16,18-20H,2-5,7-8,10-15H2,1H3,(H,24,25,26)/t19-,20- SWPXADMCNLNAGW-MXVIHJGJSA-N 50466825 CHEMBL4290222 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1890 ChEMBL 10.1016/j.bmc.2018.01.008 10.7270/Q2MW2KTQ 29398441 Degorce, SL; Anjum, R; Dillman, KS; Drew, L; Groombridge, SD; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Scott, JS; Stokes, S; Xue, Y AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466825&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138728749 433934090 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51139095 CC(C)c1ccn2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)C(C)=O)c12 InChI=1S/C21H32N6O/c1-15(2)19-8-9-27-20(19)21(22-14-23-27)24-17-4-6-18(7-5-17)26-12-10-25(11-13-26)16(3)28/h8-9,14-15,17-18H,4-7,10-13H2,1-3H3,(H,22,23,24)/t17-,18- FQBRQRVXPUQKLG-IYARVYRRSA-N 50466824 CHEMBL4278882 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1016/j.bmc.2018.01.008 10.7270/Q2MW2KTQ 29398441 Degorce, SL; Anjum, R; Dillman, KS; Drew, L; Groombridge, SD; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Scott, JS; Stokes, S; Xue, Y AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466824&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145979845 433934089 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51142830 CC[C@H](CO)Nc1nc(NCc2ccccc2)n2ncc(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-18-23-17-16(13(2)3)11-21-25(17)19(24-18)20-10-14-8-6-5-7-9-14/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 SQUNOCMDMIQIQK-OAHLLOKOSA-N 27217 (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol::GP0210::pyrazolo[1,5-a]-1,3,5-triazine, 7a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2017.09.035 10.7270/Q2HH6NRF 29046238 Cascioferro, S; Parrino, B; Spanò, V; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G Universit£ degli Studi di Palermo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search NNN 3DOG 25190761 57298927 DB08285 ZINC34285231 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51145217 CC(C)c1cnn2c(NCc3ccc(cc3)-c3ccccn3)nc(N[C@H]3CC[C@H](N)CC3)nc12 InChI=1S/C26H32N8/c1-17(2)22-16-30-34-24(22)32-25(31-21-12-10-20(27)11-13-21)33-26(34)29-15-18-6-8-19(9-7-18)23-5-3-4-14-28-23/h3-9,14,16-17,20-21H,10-13,15,27H2,1-2H3,(H2,29,31,32,33)/t20-,21- PRJNNPMIUGYOST-MEMLXQNLSA-N 50469189 CHEMBL4284209 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49 ChEMBL 10.1016/j.ejmech.2018.08.100 10.7270/Q27P9238 30199702 Compain, G; Oumata, N; Clarhaut, J; Péraudeau, E; Renoux, B; Galons, H; Papot, S Universit£ de Poitiers http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469189&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134813913 433936454 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51145222 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1016/j.ejmech.2018.08.100 10.7270/Q27P9238 30199702 Compain, G; Oumata, N; Clarhaut, J; Péraudeau, E; Renoux, B; Galons, H; Papot, S Universit£ de Poitiers http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51139012 CC(C)c1ccn2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)C(C)=O)c12 InChI=1S/C21H32N6O/c1-15(2)19-8-9-27-20(19)21(22-14-23-27)24-17-4-6-18(7-5-17)26-12-10-25(11-13-26)16(3)28/h8-9,14-15,17-18H,4-7,10-13H2,1-3H3,(H,22,23,24)/t17-,18- FQBRQRVXPUQKLG-IYARVYRRSA-N 50466824 CHEMBL4278882 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 890 ChEMBL 10.1016/j.bmc.2018.01.008 10.7270/Q2MW2KTQ 29398441 Degorce, SL; Anjum, R; Dillman, KS; Drew, L; Groombridge, SD; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Scott, JS; Stokes, S; Xue, Y AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466824&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145979845 433934089 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51139029 CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnn2ccc(C3CCOCC3)c12 InChI=1S/C23H34N6O2/c1-17(30)27-10-12-28(13-11-27)20-4-2-19(3-5-20)26-23-22-21(18-7-14-31-15-8-18)6-9-29(22)25-16-24-23/h6,9,16,18-20H,2-5,7-8,10-15H2,1H3,(H,24,25,26)/t19-,20- SWPXADMCNLNAGW-MXVIHJGJSA-N 50466825 CHEMBL4290222 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >30000 ChEMBL 10.1016/j.bmc.2018.01.008 10.7270/Q2MW2KTQ 29398441 Degorce, SL; Anjum, R; Dillman, KS; Drew, L; Groombridge, SD; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Scott, JS; Stokes, S; Xue, Y AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466825&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138728749 433934090 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51210797 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccc(Cl)cc1 InChI=1S/C18H17ClN2O/c1-21(18(22)13-6-8-15(19)9-7-13)11-10-14-12-20-17-5-3-2-4-16(14)17/h2-9,12,20H,10-11H2,1H3 IEAKWXUPKMDFOG-UHFFFAOYSA-N 50188066 CHEMBL213302::N-(2-(1H-indol-3-yl)ethyl)-4-chloro-N-methylbenzamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000000 ChEMBL 10.1021/jm5014743 10.7270/Q2PR7ZZ6 25368960 Mahale, S; Bharate, SB; Manda, S; Joshi, P; Bharate, SS; Jenkins, PR; Vishwakarma, RA; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188066&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11515154 104071892 CHEMBL213302 ZINC40567196 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51210798 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccc(cc1)C(C)(C)C InChI=1S/C22H26N2O/c1-22(2,3)18-11-9-16(10-12-18)21(25)24(4)14-13-17-15-23-20-8-6-5-7-19(17)20/h5-12,15,23H,13-14H2,1-4H3 PZVJDNBQZSXVIE-UHFFFAOYSA-N 50188064 CHEMBL209467::N-(2-(1H-indol-3-yl)ethyl)-4-tert-butyl-N-methylbenzamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000000 ChEMBL 10.1021/jm5014743 10.7270/Q2PR7ZZ6 25368960 Mahale, S; Bharate, SB; Manda, S; Joshi, P; Bharate, SS; Jenkins, PR; Vishwakarma, RA; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188064&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11624162 104071890 CHEMBL209467 ZINC35949795 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51210800 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C24H22N2O/c1-26(16-15-21-17-25-23-10-6-5-9-22(21)23)24(27)20-13-11-19(12-14-20)18-7-3-2-4-8-18/h2-14,17,25H,15-16H2,1H3 CPKLVRIYXBROSG-UHFFFAOYSA-N 50188071 CHEMBL213805::biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methyl-amide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000000 ChEMBL 10.1021/jm5014743 10.7270/Q2PR7ZZ6 25368960 Mahale, S; Bharate, SB; Manda, S; Joshi, P; Bharate, SS; Jenkins, PR; Vishwakarma, RA; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188071&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11610059 104071897 CHEMBL213805 ZINC35930674 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51210802 O=C1c2ccccc2-[n+]2ccc3c([nH]c4ccccc34)c12 InChI=1S/C18H10N2O/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20/h1-10H/p+1 WYQIPCUPNMRAKP-UHFFFAOYSA-O 59087 CHEMBL258765::Fasca-plysi::Fascaplysin Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >250000 ChEMBL 10.1021/jm5014743 10.7270/Q2PR7ZZ6 25368960 Mahale, S; Bharate, SB; Manda, S; Joshi, P; Bharate, SS; Jenkins, PR; Vishwakarma, RA; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59087&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73293 123080303 CHEMBL258765 ZINC01616841 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220687 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C22H28N8S/c1-15-20(31-22(26-15)27-16-4-2-3-5-16)18-8-9-24-21(28-18)29-19-7-6-17(14-25-19)30-12-10-23-11-13-30/h6-9,14,16,23H,2-5,10-13H2,1H3,(H,26,27)(H,24,25,28,29) JTZWTKLEXMYEMU-UHFFFAOYSA-N 50501577 CHEMBL4071812 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126534285 433913478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220688 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCCNCC2)n1 InChI=1S/C23H30N8S/c1-16-21(32-23(27-16)28-17-5-2-3-6-17)19-9-11-25-22(29-19)30-20-8-7-18(15-26-20)31-13-4-10-24-12-14-31/h7-9,11,15,17,24H,2-6,10,12-14H2,1H3,(H,27,28)(H,25,26,29,30) LICJOAWXMPKZSX-UHFFFAOYSA-N 50501578 CHEMBL4098811 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 508 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286395 433913479 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220706 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCCNCC2)n1 InChI=1S/C21H28N8S/c1-14(2)25-21-26-15(3)19(30-21)17-7-9-23-20(27-17)28-18-6-5-16(13-24-18)29-11-4-8-22-10-12-29/h5-7,9,13-14,22H,4,8,10-12H2,1-3H3,(H,25,26)(H,23,24,27,28) HBUAOMASWHOWJB-UHFFFAOYSA-N 50501592 CHEMBL4066878 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 925 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501592&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286352 433913493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220707 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1 InChI=1S/C21H28N8S/c1-14(2)24-21-25-15(3)19(30-21)17-7-8-22-20(26-17)27-18-6-5-16(13-23-18)29-11-9-28(4)10-12-29/h5-8,13-14H,9-12H2,1-4H3,(H,24,25)(H,22,23,26,27) USXJKWQIDCWKGZ-UHFFFAOYSA-N 50501591 CHEMBL4088160 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 773 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535619 433913492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220727 CN(C1CCCC1)c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)C(C)=O)n1 InChI=1S/C25H32N8OS/c1-17-23(35-25(28-17)31(3)19-6-4-5-7-19)21-10-11-26-24(29-21)30-22-9-8-20(16-27-22)33-14-12-32(13-15-33)18(2)34/h8-11,16,19H,4-7,12-15H2,1-3H3,(H,26,27,29,30) GYTNVEDSWNLDQV-UHFFFAOYSA-N 50501603 CHEMBL4093456 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501603&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126559195 433913504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220728 Cc1nc(sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1)N(C1CCCC1)C1CCCC1 InChI=1S/C27H36N8S/c1-19-25(36-27(31-19)35(20-6-2-3-7-20)21-8-4-5-9-21)23-12-13-29-26(32-23)33-24-11-10-22(18-30-24)34-16-14-28-15-17-34/h10-13,18,20-21,28H,2-9,14-17H2,1H3,(H,29,30,32,33) DEUZACBXMBZZRF-UHFFFAOYSA-N 50501602 CHEMBL4065844 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501602&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286356 433913503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220736 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)C(C)=O)n1 InChI=1S/C22H28N8OS/c1-14(2)25-22-26-15(3)20(32-22)18-7-8-23-21(27-18)28-19-6-5-17(13-24-19)30-11-9-29(10-12-30)16(4)31/h5-8,13-14H,9-12H2,1-4H3,(H,25,26)(H,23,24,27,28) PTKMSTJCOJHQGV-UHFFFAOYSA-N 50501590 CHEMBL4082236 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3717 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501590&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535633 433913491 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220737 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCOCC2)n1 InChI=1S/C20H25N7OS/c1-13(2)23-20-24-14(3)18(29-20)16-6-7-21-19(25-16)26-17-5-4-15(12-22-17)27-8-10-28-11-9-27/h4-7,12-13H,8-11H2,1-3H3,(H,23,24)(H,21,22,25,26) MIFCTDCDIAKSQG-UHFFFAOYSA-N 50501589 CHEMBL4100252 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126534280 433913490 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220738 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 364 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220739 FC(F)(F)c1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C22H25F3N8S/c23-22(24,25)19-18(34-21(32-19)29-14-3-1-2-4-14)16-7-8-27-20(30-16)31-17-6-5-15(13-28-17)33-11-9-26-10-12-33/h5-8,13-14,26H,1-4,9-12H2,(H,29,32)(H,27,28,30,31) XZQBJKPCLITHDB-UHFFFAOYSA-N 50501588 CHEMBL4102076 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 258 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535147 433913489 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220740 CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C(F)(F)F)nc1 InChI=1S/C23H27F3N8S/c1-33-10-12-34(13-11-33)16-6-7-18(28-14-16)31-21-27-9-8-17(30-21)19-20(23(24,25)26)32-22(35-19)29-15-4-2-3-5-15/h6-9,14-15H,2-5,10-13H2,1H3,(H,29,32)(H,27,28,30,31) LUHGNQLUGTWNCL-UHFFFAOYSA-N 50501587 CHEMBL4066828 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 831 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535157 433913488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220741 CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C(F)(F)F)nc1 InChI=1S/C24H27F3N8OS/c1-15(36)34-10-12-35(13-11-34)17-6-7-19(29-14-17)32-22-28-9-8-18(31-22)20-21(24(25,26)27)33-23(37-20)30-16-4-2-3-5-16/h6-9,14,16H,2-5,10-13H2,1H3,(H,30,33)(H,28,29,31,32) BXSSOAIGLMVYQR-UHFFFAOYSA-N 50501586 CHEMBL4079469 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501586&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286368 433913487 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220742 FC(F)(F)c1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCOCC2)n1 InChI=1S/C22H24F3N7OS/c23-22(24,25)19-18(34-21(31-19)28-14-3-1-2-4-14)16-7-8-26-20(29-16)30-17-6-5-15(13-27-17)32-9-11-33-12-10-32/h5-8,13-14H,1-4,9-12H2,(H,28,31)(H,26,27,29,30) RKKCETDJEOCIOI-UHFFFAOYSA-N 50501585 CHEMBL4104477 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535118 433913486 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220743 FC(F)(F)c1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)C=O)n1 InChI=1S/C23H25F3N8OS/c24-23(25,26)20-19(36-22(32-20)29-15-3-1-2-4-15)17-7-8-27-21(30-17)31-18-6-5-16(13-28-18)34-11-9-33(14-35)10-12-34/h5-8,13-15H,1-4,9-12H2,(H,29,32)(H,27,28,30,31) XLZANAXESDHDPY-UHFFFAOYSA-N 50501599 CHEMBL4072388 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501599&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535576 433913500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220744 CCN1CCN(Cc2ccc(Nc3nccc(n3)-c3sc(NC4CCCC4)nc3C)nc2)CC1 InChI=1S/C25H34N8S/c1-3-32-12-14-33(15-13-32)17-19-8-9-22(27-16-19)31-24-26-11-10-21(30-24)23-18(2)28-25(34-23)29-20-6-4-5-7-20/h8-11,16,20H,3-7,12-15,17H2,1-2H3,(H,28,29)(H,26,27,30,31) VJFMIBISXQANRG-UHFFFAOYSA-N 50501598 CHEMBL4103372 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1980 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286343 433913499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220745 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3sc(NC4CCCC4)nc3C)nc2)CC1 InChI=1S/C25H33FN8S/c1-3-33-10-12-34(13-11-33)16-18-8-9-21(27-14-18)31-24-28-15-20(26)22(32-24)23-17(2)29-25(35-23)30-19-6-4-5-7-19/h8-9,14-15,19H,3-7,10-13,16H2,1-2H3,(H,29,30)(H,27,28,31,32) POFVJRKJJBFPII-UHFFFAOYSA-N 50501597 CHEMBL4067549 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3570 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535127 433913498 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220746 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C22H27FN8S/c1-14-20(32-22(27-14)28-15-4-2-3-5-15)19-17(23)13-26-21(30-19)29-18-7-6-16(12-25-18)31-10-8-24-9-11-31/h6-7,12-13,15,24H,2-5,8-11H2,1H3,(H,27,28)(H,25,26,29,30) AMPDZRFNHCTPTF-UHFFFAOYSA-N 50501579 CHEMBL4089056 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 787 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126534479 433913480 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220747 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCCNCC2)ncc1F InChI=1S/C23H29FN8S/c1-15-21(33-23(28-15)29-16-5-2-3-6-16)20-18(24)14-27-22(31-20)30-19-8-7-17(13-26-19)32-11-4-9-25-10-12-32/h7-8,13-14,16,25H,2-6,9-12H2,1H3,(H,28,29)(H,26,27,30,31) IMDAAVXNKFRYNY-UHFFFAOYSA-N 50501580 CHEMBL4067844 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 679 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286381 433913481 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220748 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C23H29FN8S/c1-15-21(33-23(27-15)28-16-5-3-4-6-16)20-18(24)14-26-22(30-20)29-19-8-7-17(13-25-19)32-11-9-31(2)10-12-32/h7-8,13-14,16H,3-6,9-12H2,1-2H3,(H,27,28)(H,25,26,29,30) ZFNZZKVYLDBWRD-UHFFFAOYSA-N 50501581 CHEMBL4072255 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 505 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501581&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135296339 433913482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220790 CCN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H31FN8S/c1-3-32-10-12-33(13-11-32)18-8-9-20(26-14-18)30-23-27-15-19(25)21(31-23)22-16(2)28-24(34-22)29-17-6-4-5-7-17/h8-9,14-15,17H,3-7,10-13H2,1-2H3,(H,28,29)(H,26,27,30,31) UVEBMCRIHHZDFG-UHFFFAOYSA-N 50501582 CHEMBL4098475 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126559601 433913483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220791 CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H29FN8OS/c1-15-22(35-24(28-15)29-17-5-3-4-6-17)21-19(25)14-27-23(31-21)30-20-8-7-18(13-26-20)33-11-9-32(10-12-33)16(2)34/h7-8,13-14,17H,3-6,9-12H2,1-2H3,(H,28,29)(H,26,27,30,31) FQOMMDNBEIZMGZ-UHFFFAOYSA-N 50501583 CHEMBL4087343 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4990 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501583&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286391 433913484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220792 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCOCC2)ncc1F InChI=1S/C22H26FN7OS/c1-14-20(32-22(26-14)27-15-4-2-3-5-15)19-17(23)13-25-21(29-19)28-18-7-6-16(12-24-18)30-8-10-31-11-9-30/h6-7,12-13,15H,2-5,8-11H2,1H3,(H,26,27)(H,24,25,28,29) ULIMVSSEPMLVHV-UHFFFAOYSA-N 50501584 CHEMBL4102865 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135296341 433913485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220793 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCN(CC2)S(C)(=O)=O)ncc1F InChI=1S/C23H29FN8O2S2/c1-15-21(35-23(27-15)28-16-5-3-4-6-16)20-18(24)14-26-22(30-20)29-19-8-7-17(13-25-19)31-9-11-32(12-10-31)36(2,33)34/h7-8,13-14,16H,3-6,9-12H2,1-2H3,(H,27,28)(H,25,26,29,30) HDKIHQOXUMCGPU-UHFFFAOYSA-N 50501596 CHEMBL4062527 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501596&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535154 433913497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220794 CN(C)C1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C25H33FN8S/c1-16-23(35-25(29-16)30-17-6-4-5-7-17)22-20(26)15-28-24(32-22)31-21-9-8-19(14-27-21)34-12-10-18(11-13-34)33(2)3/h8-9,14-15,17-18H,4-7,10-13H2,1-3H3,(H,29,30)(H,27,28,31,32) LDHMPOHMNQEDFG-UHFFFAOYSA-N 50501595 CHEMBL4081896 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1091 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501595&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126534409 433913496 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220872 CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C23H30N8S/c1-16-21(32-23(26-16)27-17-5-3-4-6-17)19-9-10-24-22(28-19)29-20-8-7-18(15-25-20)31-13-11-30(2)12-14-31/h7-10,15,17H,3-6,11-14H2,1-2H3,(H,26,27)(H,24,25,28,29) OIQCBGFNCAFMQX-UHFFFAOYSA-N 50501612 CHEMBL4091780 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501612&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126559600 433913513 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220873 CCN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H32N8S/c1-3-31-12-14-32(15-13-31)19-8-9-21(26-16-19)30-23-25-11-10-20(29-23)22-17(2)27-24(33-22)28-18-6-4-5-7-18/h8-11,16,18H,3-7,12-15H2,1-2H3,(H,27,28)(H,25,26,29,30) QLTMJJAAHXGJMD-UHFFFAOYSA-N 50501611 CHEMBL4070914 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 141 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501611&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286342 433913512 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220874 CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H30N8OS/c1-16-22(34-24(27-16)28-18-5-3-4-6-18)20-9-10-25-23(29-20)30-21-8-7-19(15-26-21)32-13-11-31(12-14-32)17(2)33/h7-10,15,18H,3-6,11-14H2,1-2H3,(H,27,28)(H,25,26,29,30) ONRJNVZFOSHIQI-UHFFFAOYSA-N 50501610 CHEMBL4099517 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 286 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501610&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286306 433913511 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220875 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCOCC2)n1 InChI=1S/C22H27N7OS/c1-15-20(31-22(25-15)26-16-4-2-3-5-16)18-8-9-23-21(27-18)28-19-7-6-17(14-24-19)29-10-12-30-13-11-29/h6-9,14,16H,2-5,10-13H2,1H3,(H,25,26)(H,23,24,27,28) UGKFAPJXEKVBHI-UHFFFAOYSA-N 50501609 CHEMBL4081497 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501609&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535109 433913510 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220876 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCC(N)CC2)n1 InChI=1S/C23H30N8S/c1-15-21(32-23(27-15)28-17-4-2-3-5-17)19-8-11-25-22(29-19)30-20-7-6-18(14-26-20)31-12-9-16(24)10-13-31/h6-8,11,14,16-17H,2-5,9-10,12-13,24H2,1H3,(H,27,28)(H,25,26,29,30) SHEPFXMPLORKLW-UHFFFAOYSA-N 50501608 CHEMBL4061223 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 173 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501608&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126559606 433913509 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220877 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCCCC2)n1 InChI=1S/C23H29N7S/c1-16-21(31-23(26-16)27-17-7-3-4-8-17)19-11-12-24-22(28-19)29-20-10-9-18(15-25-20)30-13-5-2-6-14-30/h9-12,15,17H,2-8,13-14H2,1H3,(H,26,27)(H,24,25,28,29) NASHAYHCDKSVRA-UHFFFAOYSA-N 50501607 CHEMBL4089373 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501607&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535648 433913508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220878 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)S(C)(=O)=O)n1 InChI=1S/C23H30N8O2S2/c1-16-21(34-23(26-16)27-17-5-3-4-6-17)19-9-10-24-22(28-19)29-20-8-7-18(15-25-20)30-11-13-31(14-12-30)35(2,32)33/h7-10,15,17H,3-6,11-14H2,1-2H3,(H,26,27)(H,24,25,28,29) ZIWFXQFVSGOWAZ-UHFFFAOYSA-N 50501606 CHEMBL4069886 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1321 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501606&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135296342 433913507 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220879 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccccn2)n1 InChI=1S/C18H20N6S/c1-12-16(25-18(21-12)22-13-6-2-3-7-13)14-9-11-20-17(23-14)24-15-8-4-5-10-19-15/h4-5,8-11,13H,2-3,6-7H2,1H3,(H,21,22)(H,19,20,23,24) HMPJQPSIJCWFFX-UHFFFAOYSA-N 50501613 CHEMBL4097082 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501613&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535079 433913514 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220880 CN(C1CCCC1)c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C23H30N8S/c1-16-21(32-23(27-16)30(2)17-5-3-4-6-17)19-9-10-25-22(28-19)29-20-8-7-18(15-26-20)31-13-11-24-12-14-31/h7-10,15,17,24H,3-6,11-14H2,1-2H3,(H,25,26,28,29) VSTBDMYJXAWENH-UHFFFAOYSA-N 50501605 CHEMBL4102935 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1801 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501605&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535129 433913506 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220881 CN(C1CCCC1)c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1 InChI=1S/C24H32N8S/c1-17-22(33-24(27-17)31(3)18-6-4-5-7-18)20-10-11-25-23(28-20)29-21-9-8-19(16-26-21)32-14-12-30(2)13-15-32/h8-11,16,18H,4-7,12-15H2,1-3H3,(H,25,26,28,29) OHNWSWSUMDWFSA-UHFFFAOYSA-N 50501604 CHEMBL4084985 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1800 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501604&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286434 433913505 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220886 Cc1nc(Nc2ccccc2)sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C23H24N8S/c1-16-21(32-23(27-16)28-17-5-3-2-4-6-17)19-9-10-25-22(29-19)30-20-8-7-18(15-26-20)31-13-11-24-12-14-31/h2-10,15,24H,11-14H2,1H3,(H,27,28)(H,25,26,29,30) UNVBFURIHRAGGO-UHFFFAOYSA-N 50501601 CHEMBL4085708 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 436 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501601&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535189 433913502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220887 CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(Nc3ccccc3)nc2C)nc1 InChI=1S/C24H26N8S/c1-17-22(33-24(27-17)28-18-6-4-3-5-7-18)20-10-11-25-23(29-20)30-21-9-8-19(16-26-21)32-14-12-31(2)13-15-32/h3-11,16H,12-15H2,1-2H3,(H,27,28)(H,25,26,29,30) YTCPGIQPAHCLSI-UHFFFAOYSA-N 50501600 CHEMBL4103642 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501600&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126535094 433913501 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220888 CN(c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1)c1ccccc1 InChI=1S/C25H28N8S/c1-18-23(34-25(28-18)32(3)19-7-5-4-6-8-19)21-11-12-26-24(29-21)30-22-10-9-20(17-27-22)33-15-13-31(2)14-16-33/h4-12,17H,13-16H2,1-3H3,(H,26,27,29,30) HCDMSNJPLKSFOG-UHFFFAOYSA-N 50501594 CHEMBL4077857 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501594&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286350 433913495 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51220889 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C20H26N8S/c1-13(2)24-20-25-14(3)18(29-20)16-6-7-22-19(26-16)27-17-5-4-15(12-23-17)28-10-8-21-9-11-28/h4-7,12-13,21H,8-11H2,1-3H3,(H,24,25)(H,22,23,26,27) QRNHMYCAPGHBKI-UHFFFAOYSA-N 50501593 CHEMBL4095884 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2420 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501593&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135286354 433913494 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212007 Cn1nc(N)c(\N=N\c2ccncc2)c1N InChI=1S/C9H11N7/c1-16-9(11)7(8(10)15-16)14-13-6-2-4-12-5-3-6/h2-5H,11H2,1H3,(H2,10,15)/b14-13+ HUHDSOITAVSODF-BUHFOSPRSA-N 50498121 CHEMBL3402060 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1350 ChEMBL 10.1016/j.bmc.2015.03.025 10.7270/Q21V5HZ6 25835357 Jorda, R; Schütznerová, E; Cankař, P; Brychtová, V; Navrátilová, J; Kryštof, V Palack� University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498121&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136961394 433965386 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212021 Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)/b13-12+ AYZRKFOEZQBUEA-OUKQBFOZSA-N 50455463 CHEMBL215205 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 ChEMBL 10.1016/j.bmc.2015.03.025 10.7270/Q21V5HZ6 25835357 Jorda, R; Schütznerová, E; Cankař, P; Brychtová, V; Navrátilová, J; Kryštof, V Palack� University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135398514 433923556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212026 Nc1n[nH]c(N)c1\N=N\c1ccncc1 InChI=1S/C8H9N7/c9-7-6(8(10)15-14-7)13-12-5-1-3-11-4-2-5/h1-4H,(H5,9,10,14,15)/b13-12+ RZLCSJZALMLKCU-OUKQBFOZSA-N 123786 AAP1742 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 ChEMBL 10.1016/j.bmc.2015.03.025 10.7270/Q21V5HZ6 25835357 Jorda, R; Schütznerová, E; Cankař, P; Brychtová, V; Navrátilová, J; Kryštof, V Palack� University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123786&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 21955055 225150195 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212117 O\N=C1\C(\Nc2cc(F)c(F)cc\12)=C1\C(=O)Nc2ccc(OC(F)(F)F)cc12 InChI=1S/C17H8F5N3O3/c18-9-4-8-12(5-10(9)19)23-15(14(8)25-27)13-7-3-6(28-17(20,21)22)1-2-11(7)24-16(13)26/h1-5,23,27H,(H,24,26)/b15-13-,25-14+ LGAISEPKMUXAJE-MKQKNSIWSA-N 50498205 CHEMBL3422750 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5600 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498205&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136934903 433965470 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212118 COc1ccc2NC(=O)\C(=C3/Nc4cc(F)c(F)cc4/C/3=N\OCCO)c2c1 InChI=1S/C19H15F2N3O4/c1-27-9-2-3-14-10(6-9)16(19(26)23-14)18-17(24-28-5-4-25)11-7-12(20)13(21)8-15(11)22-18/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)/b18-16-,24-17+ RGSOPECOGHDZOA-PLWLMNJCSA-N 50498204 CHEMBL3421644 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498204&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136934907 433965469 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212123 O\N=C1\C(\Nc2cc(F)c(F)cc\12)=C1\C(=O)Nc2ccc(F)cc12 InChI=1S/C16H8F3N3O2/c17-6-1-2-11-7(3-6)13(16(23)21-11)15-14(22-24)8-4-9(18)10(19)5-12(8)20-15/h1-5,20,24H,(H,21,23)/b15-13-,22-14+ SFSDFPHZJCJWLH-CEUPHZNOSA-N 50498206 CHEMBL3422742 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1700 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498206&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136934895 433965471 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212124 Oc1[nH]c2ccccc2c1-c1[nH]c2ccccc2c1N=O InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17-18,20H FQCPPVRJPILDIK-UHFFFAOYSA-N 50132003 (Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime::(Z)-1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime::1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime::1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime::3-(3-(hydroxyimino)indolin-2-ylidene)indolin-2-one::CHEMBL126077 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132003&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5326739 104023028 CHEMBL126077 5989 ZINC18230030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212126 COc1ccc2NC(=O)\C(=C3/Nc4cc(F)c(F)cc4/C/3=N\O)c2c1 InChI=1S/C17H11F2N3O3/c1-25-7-2-3-12-8(4-7)14(17(23)21-12)16-15(22-24)9-5-10(18)11(19)6-13(9)20-16/h2-6,20,24H,1H3,(H,21,23)/b16-14-,22-15+ MWZPEWCUKPOAHS-NSWVJOTCSA-N 50498208 CHEMBL3422748 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1900 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498208&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136934901 433965473 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212128 O\N=C1\C(\Nc2cc(F)c(F)cc\12)=C1\C(=O)Nc2ccc(Cl)cc12 InChI=1S/C16H8ClF2N3O2/c17-6-1-2-11-7(3-6)13(16(23)21-11)15-14(22-24)8-4-9(18)10(19)5-12(8)20-15/h1-5,20,24H,(H,21,23)/b15-13-,22-14+ YWDLOFCAMIGPFH-CEUPHZNOSA-N 50498207 CHEMBL3422747 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498207&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136934900 433965472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51212129 O\N=C1\C(\Nc2cc(F)c(F)cc\12)=C1\C(=O)Nc2ccc(cc12)[N+]([O-])=O InChI=1S/C16H8F2N4O4/c17-9-4-8-12(5-10(9)18)19-15(14(8)21-24)13-7-3-6(22(25)26)1-2-11(7)20-16(13)23/h1-5,19,24H,(H,20,23)/b15-13-,21-14+ SPSKSFKGHNLIRL-WQGZHNTLSA-N 50498209 CHEMBL3422744 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2015.03.066 10.7270/Q24M97JJ 25908517 Yan, L; Lai, F; Chen, X; Xiao, Z Chinese Academy of Medical Sciences and Peking Union Medical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498209&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 136934897 433965474 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902958 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)NCC22CCCCC2)nc1 InChI=1S/C22H30N8O/c1-28-11-13-29(14-12-28)17-5-6-18(24-15-17)26-20-23-10-7-19(27-20)30-21(31)25-16-22(30)8-3-2-4-9-22/h5-7,10,15H,2-4,8-9,11-14,16H2,1H3,(H,25,31)(H,23,24,26,27) RBSNIGHOISZVRA-UHFFFAOYSA-N 443113 US10654831, Compound 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9630 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443113&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595677 440074298 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902961 CN1CC2(CCCCC2)N(C1=O)c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1 InChI=1S/C23H32N8O/c1-28-12-14-30(15-13-28)18-6-7-19(25-16-18)26-21-24-11-8-20(27-21)31-22(32)29(2)17-23(31)9-4-3-5-10-23/h6-8,11,16H,3-5,9-10,12-15,17H2,1-2H3,(H,24,25,26,27) BCZJHZOLBWWRJF-UHFFFAOYSA-N 443114 US10654831, Compound 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443114&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595627 440074299 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902964 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=O)N(Cc3ccccc3)CC22CCCCC2)nc1 InChI=1S/C29H36N8O/c1-34-16-18-35(19-17-34)24-10-11-25(31-20-24)32-27-30-15-12-26(33-27)37-28(38)36(21-23-8-4-2-5-9-23)22-29(37)13-6-3-7-14-29/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21-22H2,1H3,(H,30,31,32,33) KAJDQFDBXWMHBD-UHFFFAOYSA-N 443115 US10654831, Compound 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443115&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595641 440074300 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902967 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC2=O)nc1 InChI=1S/C17H22N8O/c1-23-8-10-24(11-9-23)13-2-3-14(20-12-13)21-16-18-5-4-15(22-16)25-7-6-19-17(25)26/h2-5,12H,6-11H2,1H3,(H,19,26)(H,18,20,21,22) FMPXDCWCCUNMBZ-UHFFFAOYSA-N 443116 US10654831, Compound 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9300 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443116&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595639 440074301 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902970 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CC(=O)NCC22CCCCC2)nc1 InChI=1S/C23H32N8O/c1-29-11-13-30(14-12-29)18-5-6-19(25-15-18)27-22-24-10-7-20(28-22)31-16-21(32)26-17-23(31)8-3-2-4-9-23/h5-7,10,15H,2-4,8-9,11-14,16-17H2,1H3,(H,26,32)(H,24,25,27,28) WYBDIAZRTPZHAJ-UHFFFAOYSA-N 443117 US10654831, Compound 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 750 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443117&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595618 440074302 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902971 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2CCNC(=O)C2)nc1 InChI=1S/C18H24N8O/c1-24-8-10-25(11-9-24)14-2-3-15(21-12-14)22-18-20-5-4-16(23-18)26-7-6-19-17(27)13-26/h2-5,12H,6-11,13H2,1H3,(H,19,27)(H,20,21,22,23) NETXKRRZNKEDQO-UHFFFAOYSA-N 443119 US10654831, Compound 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22900 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443119&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595633 440074304 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902974 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccccc2)nc1 InChI=1S/C28H34N8/c1-34-16-18-35(19-17-34)23-10-11-24(30-20-23)32-27-29-15-12-25(33-27)36-26(22-8-4-2-5-9-22)31-21-28(36)13-6-3-7-14-28/h2,4-5,8-12,15,20H,3,6-7,13-14,16-19,21H2,1H3,(H,29,30,32,33) LHBYGETUNLHPQT-UHFFFAOYSA-N 443123 US10654831, Compound 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443123&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595616 440074308 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902977 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccoc2)nc1 InChI=1S/C26H32N8O/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31) YVKZJQMOPKJPBN-UHFFFAOYSA-N 443124 US10654831, Compound 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443124&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595617 440074309 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 902980 CN1CCN(CC1)c1ccc(Nc2nccc(n2)N2C(=NCC22CCCCC2)c2ccsc2)nc1 InChI=1S/C26H32N8S/c1-32-12-14-33(15-13-32)21-5-6-22(28-17-21)30-25-27-11-7-23(31-25)34-24(20-8-16-35-18-20)29-19-26(34)9-3-2-4-10-26/h5-8,11,16-18H,2-4,9-10,12-15,19H2,1H3,(H,27,28,30,31) UDQUHQJBHHLXTB-UHFFFAOYSA-N 443125 US10654831, Compound 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q2JS9TFP aid1804412 US10654831 Strum, JC; Gaston, RD; Gadwood, RC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443125&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138595669 440074310 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264622 COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3 XLTFNNCXVBYBSX-UHFFFAOYSA-N 50140257 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one::5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin)::5,7-dihydroxy-8-methoxyflavone::CHEMBL16171::WOGONIN Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 198 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140257&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5281703 104029877 10043 CHEMBL16171 C10197 ZINC00899093 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264623 CC(C)Oc1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1)N1CCNCC1 InChI=1S/C22H24N2O5/c1-13(2)28-21-18(27)11-16(25)20-17(26)12-19(29-22(20)21)14-3-5-15(6-4-14)24-9-7-23-8-10-24/h3-6,11-13,23,25,27H,7-10H2,1-2H3 MVWMZXXYCVLQRN-UHFFFAOYSA-N 50516534 CHEMBL4461927 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 94 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516534&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155301374 440725116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264624 CC(C)Oc1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1)N1CCN(C)CC1 InChI=1S/C23H26N2O5/c1-14(2)29-22-19(28)12-17(26)21-18(27)13-20(30-23(21)22)15-4-6-16(7-5-15)25-10-8-24(3)9-11-25/h4-7,12-14,26,28H,8-11H2,1-3H3 YKWRNJWUWNVZOD-UHFFFAOYSA-N 50516535 CHEMBL4463420 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 179 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516535&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155301364 440725117 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264625 COc1cc(O)c2c(oc(cc2=O)-c2ccc(cc2)N2CCN(C)CC2)c1Oc1c(C)n[nH]c1C InChI=1S/C26H28N4O5/c1-15-24(16(2)28-27-15)35-25-22(33-4)14-20(32)23-19(31)13-21(34-26(23)25)17-5-7-18(8-6-17)30-11-9-29(3)10-12-30/h5-8,13-14,32H,9-12H2,1-4H3,(H,27,28) ZFEGLYHROKAIFG-UHFFFAOYSA-N 50516536 CHEMBL4446230 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516536&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155301438 440725118 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264627 COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@@](C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24)/t27-/m0/s1 ACWKGTGIJRCOOM-MHZLTWQESA-N 50516532 CHEMBL4560679 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124647268 440725114 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264628 CN1CCN(CC1)c1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(Oc3c(C)n[nH]c3C)c2o1 InChI=1S/C25H26N4O5/c1-14-23(15(2)27-26-14)34-24-20(32)12-18(30)22-19(31)13-21(33-25(22)24)16-4-6-17(7-5-16)29-10-8-28(3)9-11-29/h4-7,12-13,30,32H,8-11H2,1-3H3,(H,26,27) JGEOHIVQVGBPIH-UHFFFAOYSA-N 50516533 CHEMBL4554243 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155556435 440725115 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264630 COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3 XLTFNNCXVBYBSX-UHFFFAOYSA-N 50140257 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one::5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin)::5,7-dihydroxy-8-methoxyflavone::CHEMBL16171::WOGONIN Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140257&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5281703 104029877 10043 CHEMBL16171 C10197 ZINC00899093 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51264631 Cc1n[nH]c(C)c1Oc1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1)N1CCNCC1 InChI=1S/C24H24N4O5/c1-13-22(14(2)27-26-13)33-23-19(31)11-17(29)21-18(30)12-20(32-24(21)23)15-3-5-16(6-4-15)28-9-7-25-8-10-28/h3-6,11-12,25,29,31H,7-10H2,1-2H3,(H,26,27) ULAWEOWOXLQMRH-UHFFFAOYSA-N 50516531 CHEMBL4467886 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2019.06.024 10.7270/Q2XP789W 31238183 Wang, J; Li, T; Zhao, T; Wu, T; Liu, C; Ding, H; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516531&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155301446 440725113 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51251903 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10.0 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51251907 Nc1nc(Nc2ccc(cc2)S(=O)(=O)NCCO)nc(OCC2CCCCC2)c1N=O InChI=1S/C19H26N6O5S/c20-17-16(25-27)18(30-12-13-4-2-1-3-5-13)24-19(23-17)22-14-6-8-15(9-7-14)31(28,29)21-10-11-26/h6-9,13,21,26H,1-5,10-12H2,(H3,20,22,23,24) BOCJDTQHHGUTIM-UHFFFAOYSA-N 50511934 CHEMBL4590821 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2630 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 16719774 440720516 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51251917 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51234689 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)NCCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C49H54BF2N7O7/c1-29-25-30(2)58-39(29)26-32-14-13-31(59(32)50(58,51)52)15-16-40(60)54-18-20-64-22-24-65-23-21-63-19-17-53-36-27-41-56-37-11-7-5-9-33(37)43-44-35(28-55-48(44)61)42-34-10-6-8-12-38(34)57(46(42)45(43)56)49(3,66-41)47(36)62-4/h5-14,25-26,36,41,47,53H,15-24,27-28H2,1-4H3,(H,54,60)(H,55,61)/t36-,41-,47-,49+/m1/s1 NXSJMRCTGYTSTK-SQHKIPTKSA-N 50505541 CHEMBL4465866 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 162 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505541&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155531579 440714126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51234741 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C50H56BF2N7O7/c1-30-26-31(2)59-39(30)27-33-15-14-32(60(33)51(59,52)53)16-17-41(61)54-18-20-64-22-24-66-25-23-65-21-19-56(4)40-28-42-57-37-12-8-6-10-34(37)44-45-36(29-55-49(45)62)43-35-11-7-9-13-38(35)58(47(43)46(44)57)50(3,67-42)48(40)63-5/h6-15,26-27,40,42,48H,16-25,28-29H2,1-5H3,(H,54,61)(H,55,62)/t40-,42-,48-,50+/m1/s1 OSVUGUHRKMMBSE-INMRTLOZSA-N 50505542 CHEMBL4576489 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 116 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155552127 440714127 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51229801 CCOC(=O)CN1C(=O)\C(=N/Nc2ccc(cc2)S(N)(=O)=O)c2cc(Br)ccc12 InChI=1S/C18H17BrN4O5S/c1-2-28-16(24)10-23-15-8-3-11(19)9-14(15)17(18(23)25)22-21-12-4-6-13(7-5-12)29(20,26)27/h3-9,21H,2,10H2,1H3,(H2,20,26,27)/b22-17- BZIRYGJWYVOQKT-XLNRJJMWSA-N 50504615 CHEMBL4559132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2019.111768 10.7270/Q2QC06T5 31629164 Abo-Ashour, MF; Eldehna, WM; Nocentini, A; Bonardi, A; Bua, S; Ibrahim, HS; Elaasser, MM; Kryštof, V; Jorda, R; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504615&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155558076 440713200 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51229831 NS(=O)(=O)c1ccc(N\N=C2/C(=O)N(Cc3ccccc3)c3ccc(Cl)cc23)cc1 InChI=1S/C21H17ClN4O3S/c22-15-6-11-19-18(12-15)20(21(27)26(19)13-14-4-2-1-3-5-14)25-24-16-7-9-17(10-8-16)30(23,28)29/h1-12,24H,13H2,(H2,23,28,29)/b25-20- MYZKXOBWXUDLLE-QQTULTPQSA-N 50504629 CHEMBL4455743 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2019.111768 10.7270/Q2QC06T5 31629164 Abo-Ashour, MF; Eldehna, WM; Nocentini, A; Bonardi, A; Bua, S; Ibrahim, HS; Elaasser, MM; Kryštof, V; Jorda, R; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504629&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155524785 440713214 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51222533 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34) KGMVZSJAPXYTKH-UHFFFAOYSA-N 444543 US10662186, Compound 63::US10988476, Compound I-63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 ChEMBL 10.1016/j.ejmech.2019.06.005 10.7270/Q20K2CTJ 31200237 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Han, Y; Xiao, W; Wang, Z; Shi, W; Mao, Y; Yu, J; Xia, G; Liu, Y Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 130196825 440706790 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225414 Clc1[nH]c2ccccc2c1\C=C1\C(=O)Nc2ccccc12 InChI=1S/C17H11ClN2O/c18-16-12(10-5-1-3-7-14(10)19-16)9-13-11-6-2-4-8-15(11)20-17(13)21/h1-9,19H,(H,20,21)/b13-9+ QJKBRWSJWQVKLY-UKTHLTGXSA-N 50375670 CHEMBL261425 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50375670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50375670&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5472558 160854760 CHEMBL261425 ZINC01662968 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225422 CCCOc1cnc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)cc1O InChI=1S/C19H18IN3O4/c1-2-5-27-17-10-22-12(7-16(17)24)8-21-9-15-14-6-11(20)3-4-13(14)18(25)23-19(15)26/h3-4,6-7,9-10,21H,2,5,8H2,1H3,(H,22,24)(H,23,25,26) DXMZEMWEDCPBNA-UHFFFAOYSA-N 50267480 4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione::CHEMBL477064 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 42625175 104114303 CHEMBL477064 ZINC40917261 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225423 Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1 InChI=1S/C10H11N5O2S/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15) FVFVVRPJERUECT-UHFFFAOYSA-N 50503351 CHEMBL265964 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503351&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search U55 1JSV 2608 440711936 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225425 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225521 O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1 InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22) XOLMRFUGOINFDQ-UHFFFAOYSA-N 50205472 (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one::(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one::CHEMBL261644::CHEMBL393929 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14500 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205472&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1RO 5O12,4EOI,4EOL,4EON,4EOP,4EOS 11631681 104083820 CHEMBL261644CHEMBL393929 ZINC28821265 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225522 CC(=O)c1cnc2oc3ccc(O)cc3c2c1-c1ccccc1 InChI=1S/C19H13NO3/c1-11(21)15-10-20-19-18(17(15)12-5-3-2-4-6-12)14-9-13(22)7-8-16(14)23-19/h2-10,22H,1H3 RTDFHOPDAYJLII-UHFFFAOYSA-N 7451 1-{12-hydroxy-3-phenyl-8-oxa-6-azatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,5,9,11-hexaen-4-yl}ethan-1-one::3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine::CHEMBL133712::elbfluorene Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7451&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 403993 11108242 CHEMBL133712 ZINC01662928 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225523 CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21 InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29) RXZMYLDMFYNEIM-UHFFFAOYSA-N 31545 Milciclib::pyrazolo[4,3-h]quinazoline-3-carboxamide, 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7700 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31545&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search P48 2WIH,5VD1,5VC6 16718576 172097446 ZINC53119602 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225524 COc1ccc(CNc2nc(nc3n(cnc23)C(C)C)N(CCO)CCO)cc1 InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24) NQVIIUBWMBHLOZ-UHFFFAOYSA-N 50113739 2(bis-(hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine::2-(bis-(hydroxylethyl)amino)-6-(4-methoxybenzylamino)-9-isopropylpurine::2-{(2-Hydroxy-ethyl)-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-amino}-ethanol::CHEMBL80713 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2300 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113739&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search AJR 6INL 6918386 104007999 CHEMBL80713 5948 ZINC01487345 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225525 COc1ccc2NC(=O)\C(=C/c3cnc[nH]3)c2c1 InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)/b11-4- QNUKRWAIZMBVCU-WCIBSUBMSA-N 50503353 Su-9516 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503353&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5289419 440711938 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225526 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3900 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225527 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 101 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225528 O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21 InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25) KAJXOWFGKYKMMZ-UHFFFAOYSA-N 2672 3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione::6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole::CHEMBL268368::arcyriaflavin A Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2672&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5327723 8032440 CHEMBL268368 ZINC12354940 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225529 COc1ccc(OC)c2c1[nH]c1ccccc1c2=S InChI=1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19) KFAKESMKRPNZTM-UHFFFAOYSA-N 59089 NSC625987 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59089&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 3004085 123080305 ZINC06404102 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225530 Cc1nc2c(s1)C(=O)C=C(Nc1ccc(C)cc1)C2=O InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3 HFPLHASLIOXVGS-UHFFFAOYSA-N 50086655 2-Methyl-5-p-tolylamino-benzothiazole-4,7-dione::5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole::CHEMBL290904 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50086655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50086655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 481747 103985840 CHEMBL290904 5952 ZINC05930916 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225531 Brc1ccc2c(c1)[nH]c1c3[nH]c4ccccc4c3c3C(=O)NC(=O)c3c21 InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26) NMFKDDRQSNVETB-UHFFFAOYSA-N 6860 6-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione::Indolocarbazole deriv. 4(d) Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6860&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5330797 8036429 5950 ZINC03991710 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225532 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23) ARIOBGGRZJITQX-UHFFFAOYSA-N 6878 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n::5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search DKI 3LJ1,2CHL,4FZF,4AAA,2J51,3HMI,2JFL,4QMP,2W4O,2WU6 5330812 8036444 DB07664 5946 ZINC12355112 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225533 CCCCOc1c(c[nH]c2nncc12)C(=O)c1c(F)cc(C)cc1F InChI=1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23) SCFMWQIQBVZOQR-UHFFFAOYSA-N 50503350 CHEMBL310840 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1800 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503350&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135402864 440711935 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225534 CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C23H27N7O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29)/t17-/m1/s1 LWANFAFTTOKZAX-QGZVFWFLSA-N 50244787 (R)-2-(1-Hydroxybut-2-ylamino)-6-[3-(2-pyridyl)phenylamino]-9-isopropylpurine::CHEMBL215919 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50244787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50244787&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 25168304 104100717 CHEMBL215919 ZINC40979326 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225535 O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2cc(Br)ccc12 InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+ DDLZLOKCJHBUHD-WAVHTBQISA-N 50012188 6BIO Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012188&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search BRW 1UV5 5287844 242058111 DB03444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225536 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 50229973 (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine::4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine::CHEMBL298445::[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229973&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CK7 2WEV,1PXO,4B9D 447961 104098225 CHEMBL298445 DB02833 ZINC02047389 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225537 Nc1n[nH]c2nc3ccccc3nc12 InChI=1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14) DWHVZCLBMTZRQM-UHFFFAOYSA-N 7534 1H-pyrazolo[3,4-b]quinoxalin-3-amine::pyrazolo[3,4-b]quinoxaline deriv. 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14100 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7534&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 438981 11108319 5947 ZINC05543794 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225558 CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15+/m0/s1 UTBSBSOBZHXMHI-LSDHHAIUSA-N 50073765 CHEMBL367625::N*2*-((1R,2S)-2-Amino-cyclohexyl)-N*6*-(3-chloro-phenyl)-9-ethyl-9H-purine-2,6-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1400 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073765&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search FC8 6GUK,6GU4 2794188 103967051 CHEMBL367625 5945 ZINC02583998 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225559 NS(=O)(=O)c1ccc(N\N=C2/C(=O)Nc3ccc(Br)cc23)cc1 InChI=1S/C14H11BrN4O3S/c15-8-1-6-12-11(7-8)13(14(20)17-12)19-18-9-2-4-10(5-3-9)23(16,21)22/h1-7,18H,(H2,16,21,22)(H,17,19,20) ODZNNZYRBRRREX-UHFFFAOYSA-N 50202299 CHEMBL411491 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 106 1FVT 5858639 104081876 CHEMBL411491 ZINC29041603 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225560 CCNc1cc(N[C@H]2CC[C@H](O)CC2)nc(Nc2ccc3n(Cc4ccccc4)ccc3c2)n1 InChI=1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23- YVXCDLCJCIDFHE-AFARHQOCSA-N 50503352 CGP82996::CHEMBL2028998 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503352&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24825971 440711937 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225561 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1 InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24) OWXORKPNCHJYOF-UHFFFAOYSA-N 50235342 CHEMBL319467::NU-6102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4100 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235342&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 4SP 5M57,6BSS,2C6O,4EOK,4EOR,1H1S,5LQF,2IW8,2IW9 4566 384991216 CHEMBL319467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225562 CC(C)c1cnc(NC(=O)Cc2ccccc2)s1 InChI=1S/C14H16N2OS/c1-10(2)12-9-15-14(18-12)16-13(17)8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,15,16,17) IGRZXNLKVUEFDM-UHFFFAOYSA-N 50155210 CHEMBL426972::N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3400 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 16760027 104042714 CHEMBL426972 ZINC13827492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225600 CCOC(=O)c1cnc2oc3ccc(O)cc3c2c1-c1ccccc1 InChI=1S/C20H15NO4/c1-2-24-20(23)15-11-21-19-18(17(15)12-6-4-3-5-7-12)14-10-13(22)8-9-16(14)25-19/h3-11,22H,2H2,1H3 ZIAVUCXRGWKBBY-UHFFFAOYSA-N 50124027 6-Hydroxy-4-phenyl-benzo[4,5]furo[2,3-b]pyridine-3-carboxylic acid ethyl ester::CHEMBL132904::ethyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50124027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50124027&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 403994 104016394 CHEMBL132904 ZINC01662929 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225601 O=C1Nc2ccc3ncsc3c2\C1=C\Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1 InChI=1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27)/b15-11- GCYXEGSPUDSZJY-PTNGSMBKSA-N 153742 Oxindole (Scaffold V) Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 540 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153742&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6539118 253650861 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225602 CN1CCN(CC1)c1ccc(Nc2ncc3cc(C#N)c(=O)n(C4CCCC4)c3n2)cc1 InChI=1S/C24H27N7O/c1-29-10-12-30(13-11-29)20-8-6-19(7-9-20)27-24-26-16-18-14-17(15-25)23(32)31(22(18)28-24)21-4-2-3-5-21/h6-9,14,16,21H,2-5,10-13H2,1H3,(H,26,27,28) VADOZMZXXRBXNY-UHFFFAOYSA-N 50447512 CHEMBL3115681 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 117 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50447512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50447512&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 56649281 194945408 CHEMBL3115681 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225626 CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1 InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28) XHEQSRJCJTWWAH-UHFFFAOYSA-N 50347924 CHEMBL1802728 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5100 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347924&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search AQG 5WIJ,8EX0,8B8N,6JGM 10202471 136354610 CHEMBL1802728 5949 ZINC22309248 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51225627 OCCCNc1cc(ccn1)-c1ccnc(Nc2cccc(Cl)c2)n1 InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24) IYNDTACKOAXKBJ-UHFFFAOYSA-N 65549 3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol::3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]-2-pyridyl]amino]propan-1-ol::3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol::3-[[4-[2-[(3-chlorophenyl)amino]pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol::MLS000911536::SMR000463552::cid_644215 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1021/acs.jmedchem.8b00049 10.7270/Q2FB5665 30234987 Jorda, R; Hendrychová, D; Voller, J; Řezníčková, E; Gucký, T; Kryštof, V Palack£ University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65549&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 8II 7S6V 644215 252644026 ZINC01541868 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51238571 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.9 ChEMBL 10.1016/j.ejmech.2018.10.052 10.7270/Q2W380MT 30384048 Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274459 CC(C)Cc1noc(n1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C26H29F3N8O2/c1-16(2)11-22-33-24(39-35-22)18-3-4-19-20(13-18)32-25(31-19)34-21-12-17(5-6-30-21)15-36-7-9-37(10-8-36)23(38)14-26(27,28)29/h3-6,12-13,16H,7-11,14-15H2,1-2H3,(H2,30,31,32,34) UDQFLASTRAMKLW-UHFFFAOYSA-N 50520149 CHEMBL4547610::US10894784, Example 18.01 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520149&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245842 440728731 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274460 Cn1cc(cn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C24H25F3N8O/c1-33-15-18(13-29-33)17-2-3-19-20(11-17)31-23(30-19)32-21-10-16(4-5-28-21)14-34-6-8-35(9-7-34)22(36)12-24(25,26)27/h2-5,10-11,13,15H,6-9,12,14H2,1H3,(H2,28,30,31,32) RDFHITQJRDVSMP-UHFFFAOYSA-N 50520147 CHEMBL4436416::US10894784, Example 37.01 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520147&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129246130 440728729 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274461 FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cnn(CC4CC4)c3)c2)CC1 InChI=1S/C27H29F3N8O/c28-27(29,30)13-25(39)37-9-7-36(8-10-37)15-19-5-6-31-24(11-19)35-26-33-22-4-3-20(12-23(22)34-26)21-14-32-38(17-21)16-18-1-2-18/h3-6,11-12,14,17-18H,1-2,7-10,13,15-16H2,(H2,31,33,34,35) SSMPZXRXMBEUFU-UHFFFAOYSA-N 50520161 CHEMBL4468020::US10894784, Example 39.01.02 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9190 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520161&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245795 440728743 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274462 Cc1cc(ccn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C26H26F3N7O/c1-17-12-20(5-7-30-17)19-2-3-21-22(14-19)33-25(32-21)34-23-13-18(4-6-31-23)16-35-8-10-36(11-9-35)24(37)15-26(27,28)29/h2-7,12-14H,8-11,15-16H2,1H3,(H2,31,32,33,34) SINJOIVMLYFADD-UHFFFAOYSA-N 50520160 CHEMBL4515413::US10894784, Example 01.03 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520160&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245623 440728742 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274463 CN(C)c1cc(ccn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C27H29F3N8O/c1-36(2)24-15-20(6-8-32-24)19-3-4-21-22(14-19)34-26(33-21)35-23-13-18(5-7-31-23)17-37-9-11-38(12-10-37)25(39)16-27(28,29)30/h3-8,13-15H,9-12,16-17H2,1-2H3,(H2,31,33,34,35) AKBNGGYXMZTHEB-UHFFFAOYSA-N 50520175 CHEMBL4451595::US10894784, Example 135.02 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 263 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520175&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137479140 440728757 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274464 COCc1cc(ncn1)-c1ccc2nc(Nc3cc(ccn3)[C@@H](C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1 InChI=1S/C27H29F3N8O2/c1-17(37-7-9-38(10-8-37)25(39)14-27(28,29)30)18-5-6-31-24(12-18)36-26-34-21-4-3-19(11-23(21)35-26)22-13-20(15-40-2)32-16-33-22/h3-6,11-13,16-17H,7-10,14-15H2,1-2H3,(H2,31,34,35,36)/t17-/m1/s1 MZHPEELZCYWEHG-QGZVFWFLSA-N 50520150 CHEMBL4566796 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5110 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520150&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155543566 440728732 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274465 CN(C)c1cc(ncn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C26H28F3N9O/c1-36(2)23-13-20(31-16-32-23)18-3-4-19-21(12-18)34-25(33-19)35-22-11-17(5-6-30-22)15-37-7-9-38(10-8-37)24(39)14-26(27,28)29/h3-6,11-13,16H,7-10,14-15H2,1-2H3,(H2,30,33,34,35) SNJRVUBJSCKVLN-UHFFFAOYSA-N 50520158 CHEMBL4453292::US10894784, Example 143.02 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14400 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520158&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245363 440728740 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274466 CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc(ccn3)[C@@H](C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1 InChI=1S/C28H31F3N8O2/c1-17(2)41-23-15-32-16-34-26(23)20-4-5-21-22(12-20)36-27(35-21)37-24-13-19(6-7-33-24)18(3)38-8-10-39(11-9-38)25(40)14-28(29,30)31/h4-7,12-13,15-18H,8-11,14H2,1-3H3,(H2,33,35,36,37)/t18-/m1/s1 CLYZLUAUBTXCPL-GOSISDBHSA-N 50520159 CHEMBL4543618 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 824 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520159&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146014951 440728741 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274498 FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)C#N)c2)CC1 InChI=1S/C21H20F3N7O/c22-21(23,24)11-19(32)31-7-5-30(6-8-31)13-15-3-4-26-18(10-15)29-20-27-16-2-1-14(12-25)9-17(16)28-20/h1-4,9-10H,5-8,11,13H2,(H2,26,27,28,29) BNVGYGOBIHDVET-UHFFFAOYSA-N 50520145 CHEMBL4459120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520145&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155526827 440728727 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274522 FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)C(=O)NCC3CC3)c2)CC1 InChI=1S/C25H28F3N7O2/c26-25(27,28)13-22(36)35-9-7-34(8-10-35)15-17-5-6-29-21(11-17)33-24-31-19-4-3-18(12-20(19)32-24)23(37)30-14-16-1-2-16/h3-6,11-12,16H,1-2,7-10,13-15H2,(H,30,37)(H2,29,31,32,33) BYGZCGOGQACGKA-UHFFFAOYSA-N 50520169 CHEMBL4456062 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520169&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155525041 440728751 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274534 C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2nc(C)no2)c1 InChI=1S/C24H25F3N8O2/c1-14(34-7-9-35(10-8-34)21(36)13-24(25,26)27)16-5-6-28-20(12-16)32-23-30-18-4-3-17(11-19(18)31-23)22-29-15(2)33-37-22/h3-6,11-12,14H,7-10,13H2,1-2H3,(H2,28,30,31,32)/t14-/m1/s1 SYMILEXMAHCATG-CQSZACIVSA-N 50520174 CHEMBL4553949::US10894784, Example 16.06.02.A Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1520 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520174&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245211 440728756 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274535 C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CCC3)c2)c1 InChI=1S/C29H33F3N8O/c1-19(38-9-11-39(12-10-38)27(41)15-29(30,31)32)21-7-8-33-26(14-21)37-28-35-24-6-5-22(13-25(24)36-28)23-16-34-40(18-23)17-20-3-2-4-20/h5-8,13-14,16,18-20H,2-4,9-12,15,17H2,1H3,(H2,33,35,36,37)/t19-/m1/s1 CCQLYJZEWHWASR-LJQANCHMSA-N 50520157 CHEMBL4436188 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520157&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155511461 440728739 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274536 Cc1cc(ncn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C25H25F3N8O/c1-16-10-20(31-15-30-16)18-2-3-19-21(12-18)33-24(32-19)34-22-11-17(4-5-29-22)14-35-6-8-36(9-7-35)23(37)13-25(26,27)28/h2-5,10-12,15H,6-9,13-14H2,1H3,(H2,29,32,33,34) BTIIUKSFWMYFNV-UHFFFAOYSA-N 50520155 CHEMBL4552254::US10894784, Example 30.01.01 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 320 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520155&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129261641 440728737 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274569 Cc1noc(n1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C23H23F3N8O2/c1-14-28-21(36-32-14)16-2-3-17-18(11-16)30-22(29-17)31-19-10-15(4-5-27-19)13-33-6-8-34(9-7-33)20(35)12-23(24,25)26/h2-5,10-11H,6-9,12-13H2,1H3,(H2,27,29,30,31) UOPCRSIUYMGQCP-UHFFFAOYSA-N 50520168 CHEMBL4549459::US10894784, Example 16.01.02 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 455 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520168&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245526 440728750 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274570 C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(OCC3CC3)ncn2)c1 InChI=1S/C29H31F3N8O2/c1-18(39-8-10-40(11-9-39)27(41)15-29(30,31)32)20-6-7-33-25(13-20)38-28-36-22-5-4-21(12-24(22)37-28)23-14-26(35-17-34-23)42-16-19-2-3-19/h4-7,12-14,17-19H,2-3,8-11,15-16H2,1H3,(H2,33,36,37,38)/t18-/m1/s1 FVHKTXLAWSFSNK-GOSISDBHSA-N 50520165 CHEMBL4454902 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16100 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520165&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155523990 440728747 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274577 CCn1cc(cn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 InChI=1S/C25H27F3N8O/c1-2-36-16-19(14-30-36)18-3-4-20-21(12-18)32-24(31-20)33-22-11-17(5-6-29-22)15-34-7-9-35(10-8-34)23(37)13-25(26,27)28/h3-6,11-12,14,16H,2,7-10,13,15H2,1H3,(H2,29,31,32,33) QTSKVQLIRGIGDV-UHFFFAOYSA-N 50520162 CHEMBL4453481::US10894784, Example 38.02 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1460 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520162&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129245517 440728744 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274582 C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3)c2)c1 InChI=1S/C28H31F3N8O/c1-18(37-8-10-38(11-9-37)26(40)14-28(29,30)31)20-6-7-32-25(13-20)36-27-34-23-5-4-21(12-24(23)35-27)22-15-33-39(17-22)16-19-2-3-19/h4-7,12-13,15,17-19H,2-3,8-11,14,16H2,1H3,(H2,32,34,35,36)/t18-/m1/s1 WEFRCKPVMWDRAK-GOSISDBHSA-N 50520142 CHEMBL4435393 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520142&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145714274 440728724 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272371 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3)S(=O)(=O)NCCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C27H35N7O3S2/c1-33(2)26(35)24-17-20-18-29-27(32-25(20)34(24)22-9-5-6-10-22)31-21-11-13-23(14-12-21)39(36,37)30-16-8-4-3-7-15-28-19-38/h11-14,17-18,22,30H,3-10,15-16H2,1-2H3,(H,29,31,32) JMMUQUKOEOPQHB-UHFFFAOYSA-N 50519549 CHEMBL4573953 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519549&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155563601 440728131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272372 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3O)C(=O)NCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C26H31N7O3S/c1-32(2)25(36)21-13-18-15-29-26(31-23(18)33(21)19-7-3-4-8-19)30-20-10-9-17(14-22(20)34)24(35)28-12-6-5-11-27-16-37/h9-10,13-15,19,34H,3-8,11-12H2,1-2H3,(H,28,35)(H,29,30,31) CSRCSSRWLNLHEF-UHFFFAOYSA-N 50519550 CHEMBL4466046 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519550&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155531793 440728132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272373 CN(C)C(=O)c1cc2cnc(Nc3cccc(NC(=O)CCCCCCCN=C=S)c3)nc2n1C1CCCC1 InChI=1S/C29H37N7O2S/c1-35(2)28(38)25-17-21-19-31-29(34-27(21)36(25)24-13-7-8-14-24)33-23-12-10-11-22(18-23)32-26(37)15-6-4-3-5-9-16-30-20-39/h10-12,17-19,24H,3-9,13-16H2,1-2H3,(H,32,37)(H,31,33,34) YFJULKCXZDASLJ-UHFFFAOYSA-N 50519551 CHEMBL4569530 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519551&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155550557 440728133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272375 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 197 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272376 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3)C(=O)NCCCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C29H37N7O2S/c1-35(2)28(38)25-18-22-19-32-29(34-26(22)36(25)24-10-6-7-11-24)33-23-14-12-21(13-15-23)27(37)31-17-9-5-3-4-8-16-30-20-39/h12-15,18-19,24H,3-11,16-17H2,1-2H3,(H,31,37)(H,32,33,34) QWELELWUCGKOGI-UHFFFAOYSA-N 50519552 CHEMBL4434746 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519552&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155510741 440728134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272377 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3F)C(=O)NCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C27H32FN7O2S/c1-34(2)26(37)23-15-19-16-31-27(33-24(19)35(23)20-8-4-5-9-20)32-22-11-10-18(14-21(22)28)25(36)30-13-7-3-6-12-29-17-38/h10-11,14-16,20H,3-9,12-13H2,1-2H3,(H,30,36)(H,31,32,33) FPKVUHOVRYFYRM-UHFFFAOYSA-N 50519553 CHEMBL4474633 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155537187 440728135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272378 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3F)C(=O)NCCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C28H34FN7O2S/c1-35(2)27(38)24-16-20-17-32-28(34-25(20)36(24)21-9-5-6-10-21)33-23-12-11-19(15-22(23)29)26(37)31-14-8-4-3-7-13-30-18-39/h11-12,15-17,21H,3-10,13-14H2,1-2H3,(H,31,37)(H,32,33,34) NOGROWIFEYWZNS-UHFFFAOYSA-N 50519554 CHEMBL4445923 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519554&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155518278 440728136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272379 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3F)C(=O)NCCCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C29H36FN7O2S/c1-36(2)28(39)25-17-21-18-33-29(35-26(21)37(25)22-10-6-7-11-22)34-24-13-12-20(16-23(24)30)27(38)32-15-9-5-3-4-8-14-31-19-40/h12-13,16-18,22H,3-11,14-15H2,1-2H3,(H,32,38)(H,33,34,35) JYNYRSICWVGSBY-UHFFFAOYSA-N 50519555 CHEMBL4442345 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519555&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155515972 440728137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272380 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3O)C(=O)NCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C27H33N7O3S/c1-33(2)26(37)22-14-19-16-30-27(32-24(19)34(22)20-8-4-5-9-20)31-21-11-10-18(15-23(21)35)25(36)29-13-7-3-6-12-28-17-38/h10-11,14-16,20,35H,3-9,12-13H2,1-2H3,(H,29,36)(H,30,31,32) MEHMJRAEVOOLEJ-UHFFFAOYSA-N 50519556 CHEMBL4556152 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155556955 440728138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272381 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3F)C(=O)NCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C25H28FN7O2S/c1-32(2)24(35)21-13-17-14-29-25(31-22(17)33(21)18-6-3-4-7-18)30-20-9-8-16(12-19(20)26)23(34)28-11-5-10-27-15-36/h8-9,12-14,18H,3-7,10-11H2,1-2H3,(H,28,34)(H,29,30,31) VMUNFCCUFVSDMF-UHFFFAOYSA-N 50519557 CHEMBL4463566 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519557&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155529938 440728139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272382 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3O)C(=O)NCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C25H29N7O3S/c1-31(2)24(35)20-12-17-14-28-25(30-22(17)32(20)18-6-3-4-7-18)29-19-9-8-16(13-21(19)33)23(34)27-11-5-10-26-15-36/h8-9,12-14,18,33H,3-7,10-11H2,1-2H3,(H,27,34)(H,28,29,30) AUXDELXCOZGQCB-UHFFFAOYSA-N 50519558 CHEMBL4468293 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155532995 440728140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272383 CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCCCCN=C=S)cc3F)nc2n1C1CCCC1 InChI=1S/C29H36FN7O2S/c1-36(2)28(39)25-16-20-18-32-29(35-27(20)37(25)22-10-7-8-11-22)34-24-14-13-21(17-23(24)30)33-26(38)12-6-4-3-5-9-15-31-19-40/h13-14,16-18,22H,3-12,15H2,1-2H3,(H,33,38)(H,32,34,35) MKXLWDDUJVZEEW-UHFFFAOYSA-N 50519559 CHEMBL4543127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155552067 440728141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272385 CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCCCCN=C=S)cc3)nc2n1C1CCCC1 InChI=1S/C29H37N7O2S/c1-35(2)28(38)25-18-21-19-31-29(34-27(21)36(25)24-10-7-8-11-24)33-23-15-13-22(14-16-23)32-26(37)12-6-4-3-5-9-17-30-20-39/h13-16,18-19,24H,3-12,17H2,1-2H3,(H,32,37)(H,31,33,34) LLMKBTGLZJIAMY-UHFFFAOYSA-N 50519560 CHEMBL4548580 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138911336 440728142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272387 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3)S(=O)(=O)NCCCCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C28H37N7O3S2/c1-34(2)27(36)25-18-21-19-30-28(33-26(21)35(25)23-10-6-7-11-23)32-22-12-14-24(15-13-22)40(37,38)31-17-9-5-3-4-8-16-29-20-39/h12-15,18-19,23,31H,3-11,16-17H2,1-2H3,(H,30,32,33) YXPYASILVCWNCO-UHFFFAOYSA-N 50519561 CHEMBL4522831 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155543641 440728143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51272389 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3F)C(=O)NCCCCN=C=S)nc2n1C1CCCC1 InChI=1S/C26H30FN7O2S/c1-33(2)25(36)22-14-18-15-30-26(32-23(18)34(22)19-7-3-4-8-19)31-21-10-9-17(13-20(21)27)24(35)29-12-6-5-11-28-16-37/h9-10,13-15,19H,3-8,11-12H2,1-2H3,(H,29,35)(H,30,31,32) BFOVXCGFLRZNCR-UHFFFAOYSA-N 50519562 CHEMBL4592737 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1016/j.ejmech.2019.07.038 10.7270/Q25B05VW 31376566 Wang, X; Yu, C; Wang, C; Ma, Y; Wang, T; Li, Y; Huang, Z; Zhou, M; Sun, P; Zheng, J; Yang, S; Fan, Y; Xiang, R Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155569345 440728144 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51267909 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51267917 CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3/t12-,14+/m1/s1 QLUYMIVVAYRECT-OCCSQVGLSA-N 50193086 CHEMBL3969723 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 23643976 375076096 CHEMBL3969723 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51267926 COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3 XLTFNNCXVBYBSX-UHFFFAOYSA-N 50140257 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one::5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin)::5,7-dihydroxy-8-methoxyflavone::CHEMBL16171::WOGONIN Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140257&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5281703 104029877 10043 CHEMBL16171 C10197 ZINC00899093 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51267930 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(C)cc2=O InChI=1S/C16H19NO5/c1-8-5-10(18)15-12(20)6-11(19)14(16(15)22-8)9-3-4-17(2)7-13(9)21/h5-6,9,13,19-21H,3-4,7H2,1-2H3/t9-,13+/m0/s1 MOCVYVBNJQIVOV-TVQRCGJNSA-N 50189885 Rohitukine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50189885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50189885&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 13422573 346535251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51273063 CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) WVGDUQVQWLHVEA-UHFFFAOYSA-N 50519662 CHEMBL4438748 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01143 10.7270/Q2MC93FG 31693351 Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519662&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155513187 440728244 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51274381 C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(C)ncn2)c1 InChI=1S/C26H27F3N8O/c1-16-11-21(32-15-31-16)19-3-4-20-22(12-19)34-25(33-20)35-23-13-18(5-6-30-23)17(2)36-7-9-37(10-8-36)24(38)14-26(27,28)29/h3-6,11-13,15,17H,7-10,14H2,1-2H3,(H2,30,33,34,35)/t17-/m1/s1 HGCJKDOLUCMPFE-QGZVFWFLSA-N 50520148 CHEMBL4538751::US10894784, Example 30.03.01.A Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2130 ChEMBL 10.1021/acs.jmedchem.9b01460 10.7270/Q2CN7795 31859507 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Bayer AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520148&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 129246093 440728730 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51326531 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 LYADGAGFYYXXIO-ZWKOTPCHSA-N 50536679 CHEMBL4568087 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536679&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 59603842 440827503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51326602 FC(F)(F)CNC(=O)c1cc(cs1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCCCC2)cc1 InChI=1S/C26H26F3N5O2S/c27-26(28,29)17-31-25(35)23-12-19(16-37-23)22-14-32-34-15-20(13-30-24(22)34)18-4-6-21(7-5-18)36-11-10-33-8-2-1-3-9-33/h4-7,12-16H,1-3,8-11,17H2,(H,31,35) QNABDSWBQJKBHK-UHFFFAOYSA-N 50536675 CHEMBL4569508 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536675&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24759534 440827499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51326634 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)NCC(F)(F)F InChI=1S/C17H13F3N6OS/c1-25-6-12(4-23-25)11-3-21-15-13(5-24-26(15)7-11)10-2-14(28-8-10)16(27)22-9-17(18,19)20/h2-8H,9H2,1H3,(H,22,27) UEFCSGDOOJJXTN-UHFFFAOYSA-N 50536678 CHEMBL4550702 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536678&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 59603829 440827502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51326660 Cc1sc(cc1-c1cnn2cc(Cl)cnc12)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F InChI=1S/C18H18ClF2N5OS/c1-9-11(12-7-24-26-8-10(19)6-23-16(12)26)5-14(28-9)17(27)25-15-13(22)3-2-4-18(15,20)21/h5-8,13,15H,2-4,22H2,1H3,(H,25,27)/t13-,15-/m1/s1 NGFGTMFVWSDFPS-UKRRQHHQSA-N 50536681 CHEMBL4552628 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536681&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 89735655 440827505 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51277959 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 ChEMBL 10.1021/acs.jmedchem.9b00189 10.7270/Q2G1647C 30943029 Jorda, R; Havlíček, L; Šturc, A; Tušková, D; Daumová, L; Alam, M; Škerlová, J; Nekardová, M; Peřina, M; Pospíšil, T; Široká, J; Urbánek, L; Pachl, P; Řezáčová, P; Strnad, M; Klener, P; Kryštof, V Palack£ University and Institute of Experimental Botany http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51277977 CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(SCCN)nc12 InChI=1S/C22H25N7S/c1-14(2)18-19-20(29-28-18)21(27-22(26-19)30-12-10-23)25-13-15-6-8-16(9-7-15)17-5-3-4-11-24-17/h3-9,11,14H,10,12-13,23H2,1-2H3,(H,28,29)(H,25,26,27) PCQPAKMJSYGXRE-UHFFFAOYSA-N 50521533 CHEMBL4540226 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.9b00189 10.7270/Q2G1647C 30943029 Jorda, R; Havlíček, L; Šturc, A; Tušková, D; Daumová, L; Alam, M; Škerlová, J; Nekardová, M; Peřina, M; Pospíšil, T; Široká, J; Urbánek, L; Pachl, P; Řezáčová, P; Strnad, M; Klener, P; Kryštof, V Palack£ University and Institute of Experimental Botany http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138105941 440730115 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51277987 CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12,15-16,19,32H,4,13-14H2,1-3H3,(H2,26,28,29,30)/t19-/m1/s1 HOCBJBNQIQQQGT-LJQANCHMSA-N 50154937 CHEMBL518800 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 272 ChEMBL 10.1021/acs.jmedchem.9b00189 10.7270/Q2G1647C 30943029 Jorda, R; Havlíček, L; Šturc, A; Tušková, D; Daumová, L; Alam, M; Škerlová, J; Nekardová, M; Peřina, M; Pospíšil, T; Široká, J; Urbánek, L; Pachl, P; Řezáčová, P; Strnad, M; Klener, P; Kryštof, V Palack£ University and Institute of Experimental Botany http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RC8 3DDP,6TD3 10224714 340133507 CHEMBL518800 DB08463 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51327199 COc1cc(ccc1OS(C)(=O)=O)-c1nc2ccccc2c(=O)[nH]1 InChI=1S/C16H14N2O5S/c1-22-14-9-10(7-8-13(14)23-24(2,20)21)15-17-12-6-4-3-5-11(12)16(19)18-15/h3-9H,1-2H3,(H,17,18,19) NPVBHWSQIGVFRG-UHFFFAOYSA-N 50536933 CHEMBL4061054 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2019.01.011 10.7270/Q22R3W6D 30665142 Sonawane, V; Mohd Siddique, MU; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137634527 440827757 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51327200 Clc1cccc(NC(=O)COc2ccc(cc2)-c2nc3ccccc3c(=O)[nH]2)c1 InChI=1S/C22H16ClN3O3/c23-15-4-3-5-16(12-15)24-20(27)13-29-17-10-8-14(9-11-17)21-25-19-7-2-1-6-18(19)22(28)26-21/h1-12H,13H2,(H,24,27)(H,25,26,28) MDHSFSUMZBWHRU-UHFFFAOYSA-N 50536931 CHEMBL4578017 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2019.01.011 10.7270/Q22R3W6D 30665142 Sonawane, V; Mohd Siddique, MU; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155564817 440827755 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51327215 COc1ccc(cc1OCC(=O)NC1CCCCC1)-c1nc2ccccc2c(=O)[nH]1 InChI=1S/C23H25N3O4/c1-29-19-12-11-15(22-25-18-10-6-5-9-17(18)23(28)26-22)13-20(19)30-14-21(27)24-16-7-3-2-4-8-16/h5-6,9-13,16H,2-4,7-8,14H2,1H3,(H,24,27)(H,25,26,28) VAWMVQAKEDXTNH-UHFFFAOYSA-N 50536934 CHEMBL4561548 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >50000 ChEMBL 10.1016/j.ejmech.2019.01.011 10.7270/Q22R3W6D 30665142 Sonawane, V; Mohd Siddique, MU; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155558740 440827758 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51327220 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2019.01.011 10.7270/Q22R3W6D 30665142 Sonawane, V; Mohd Siddique, MU; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51327224 COc1ccccc1NC(=O)COc1ccc(cc1OC)-c1nc2ccccc2c(=O)[nH]1 InChI=1S/C24H21N3O5/c1-30-19-10-6-5-9-18(19)25-22(28)14-32-20-12-11-15(13-21(20)31-2)23-26-17-8-4-3-7-16(17)24(29)27-23/h3-13H,14H2,1-2H3,(H,25,28)(H,26,27,29) XXSREMXIMKCNHF-UHFFFAOYSA-N 50536932 CHEMBL4542308 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2019.01.011 10.7270/Q22R3W6D 30665142 Sonawane, V; Mohd Siddique, MU; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B De Montfort University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536932&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155551528 440827756 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288066 Cc1cccc(Nc2ncc3CCCCc3n2)c1 InChI=1S/C15H17N3/c1-11-5-4-7-13(9-11)17-15-16-10-12-6-2-3-8-14(12)18-15/h4-5,7,9-10H,2-3,6,8H2,1H3,(H,16,17,18) IPZUHNOYKQXXBS-UHFFFAOYSA-N 50525156 CHEMBL4476248 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525156&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155538384 440733738 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288092 NS(=O)(=O)c1cccc(Nc2ncc3CCCCc3n2)c1 InChI=1S/C14H16N4O2S/c15-21(19,20)12-6-3-5-11(8-12)17-14-16-9-10-4-1-2-7-13(10)18-14/h3,5-6,8-9H,1-2,4,7H2,(H2,15,19,20)(H,16,17,18) ASNDURJGUUDPHG-UHFFFAOYSA-N 50525155 CHEMBL4561424 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525155&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155559110 440733737 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288093 COc1cccc(Nc2ncc3CCCCc3n2)c1 InChI=1S/C15H17N3O/c1-19-13-7-4-6-12(9-13)17-15-16-10-11-5-2-3-8-14(11)18-15/h4,6-7,9-10H,2-3,5,8H2,1H3,(H,16,17,18) DYNWEDRLLZIBOF-UHFFFAOYSA-N 50525157 CHEMBL4460155 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525157&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155527932 440733739 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288094 Cc1ccccc1Nc1ncc2CCCCc2n1 InChI=1S/C15H17N3/c1-11-6-2-4-8-13(11)17-15-16-10-12-7-3-5-9-14(12)18-15/h2,4,6,8,10H,3,5,7,9H2,1H3,(H,16,17,18) GXNCJJUXJCUZSD-UHFFFAOYSA-N 50525160 CHEMBL4522230 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525160&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155543060 440733742 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288095 Cc1ccc(Nc2ncc3CCCCc3n2)cc1 InChI=1S/C15H17N3/c1-11-6-8-13(9-7-11)17-15-16-10-12-4-2-3-5-14(12)18-15/h6-10H,2-5H2,1H3,(H,16,17,18) DQBAQLBXYGRJMA-UHFFFAOYSA-N 50525161 CHEMBL4557901 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525161&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66493692 440733743 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288118 [O-][N+](=O)c1cccc(Nc2ncc3CCCCc3n2)c1 InChI=1S/C14H14N4O2/c19-18(20)12-6-3-5-11(8-12)16-14-15-9-10-4-1-2-7-13(10)17-14/h3,5-6,8-9H,1-2,4,7H2,(H,15,16,17) IDELUCHFZTYRPZ-UHFFFAOYSA-N 50525159 CHEMBL4471293 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525159&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155534846 440733741 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51288125 CCc1cccc(Nc2ncc3CCCCc3n2)c1 InChI=1S/C16H19N3/c1-2-12-6-5-8-14(10-12)18-16-17-11-13-7-3-4-9-15(13)19-16/h5-6,8,10-11H,2-4,7,9H2,1H3,(H,17,18,19) BEUXLHXNNKSHIB-UHFFFAOYSA-N 50525158 CHEMBL4515564 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >5000 ChEMBL 10.1021/acsmedchemlett.9b00029 10.7270/Q2X06BGP 31098000 Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525158&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155539890 440733740 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297369 COc1cc(F)ccc1-c1cc(Nc2cc(C[S@](C)(=N)=O)ccn2)ncc1F InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)/t28-/m1/s1 YZCUMZWULWOUMD-MUUNZHRXSA-N 50528809 CHEMBL4589249 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528809&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155567919 440737391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297376 CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C31H35ClN8O2/c1-31(39-29(42)26-13-12-21(17-33-26)36-27(41)11-7-15-40(2)3)14-6-8-20(16-31)37-30-35-19-24(32)28(38-30)23-18-34-25-10-5-4-9-22(23)25/h4-5,7,9-13,17-20,34H,6,8,14-16H2,1-3H3,(H,36,41)(H,39,42)(H,35,37,38)/b11-7+/t20-,31+/m1/s1 SCJNYBYSTCRPAO-LXBQGUBHSA-N 50528812 CHEMBL4582951 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 914 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528812&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118426108 440737394 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297379 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7-22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1 RUBYHLPRZRMTJO-MOVYNIQHSA-N 50528813 CHEMBL4163879 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 834 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528813&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118025540 440737395 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297382 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2831 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297390 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C31H34ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-4,6,9-15,18-19,22-23,33H,5,7-8,16-17H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+/t22-,23+/m0/s1 DLISTLYUFVETPG-YPCZXWAUSA-N 50528811 CHEMBL4441405 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 627 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528811&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 91754660 440737393 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297404 CCc1cnn2c(Nc3cccc(NC(=O)C=C)c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C24H30N6O2/c1-3-17-16-25-30-22(26-18-8-7-9-19(14-18)27-23(32)4-2)15-21(28-24(17)30)29-12-6-5-10-20(29)11-13-31/h4,7-9,14-16,20,26,31H,2-3,5-6,10-13H2,1H3,(H,27,32)/t20-/m0/s1 CDCHESFKYUNJPV-FQEVSTJZSA-N 50528815 CHEMBL4468670 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528815&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122596923 440737397 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297412 COc1cc(F)ccc1-c1cc(Nc2cc(C[S@](C)(=N)=O)ccn2)ncc1F InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)/t28-/m1/s1 YZCUMZWULWOUMD-MUUNZHRXSA-N 50528809 CHEMBL4589249 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528809&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155567919 440737391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297438 CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1 DLPIYBKBHMZCJI-WBVHZDCISA-N 106950 US8592581, 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24983461 174009261 ZINC96177788 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297439 COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@](C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24)/t27-/m1/s1 ACWKGTGIJRCOOM-HHHXNRCGSA-N 50528818 CHEMBL4439321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 121488167 440737400 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297443 COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@](C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24)/t27-/m1/s1 ACWKGTGIJRCOOM-HHHXNRCGSA-N 50528818 CHEMBL4439321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 121488167 440737400 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51297446 CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C30H33ClN8O2/c1-39(2)14-6-11-27(40)35-21-12-13-26(32-16-21)29(41)36-19-7-5-8-20(15-19)37-30-34-18-24(31)28(38-30)23-17-33-25-10-4-3-9-22(23)25/h3-4,6,9-13,16-20,33H,5,7-8,14-15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+/t19-,20+/m0/s1 WFWFIAFTMSUDNO-CHUTXNTCSA-N 50528814 CHEMBL4436535 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 226 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528814&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 91938075 440737396 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 958914 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 958917 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979485 CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(c3n2)C(C)(C)CNC4=O)nc1 InChI=1S/C22H28N8O2/c1-22(2)13-25-20(32)16-10-17(31)15-12-24-21(27-19(15)30(16)22)26-18-5-4-14(11-23-18)29-8-6-28(3)7-9-29/h4-5,11-12,16H,6-10,13H2,1-3H3,(H,25,32)(H,23,24,26,27) UNHLUCCQTMZQPA-UHFFFAOYSA-N 472673 10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyridin-2- yl)amino)-6,6a,9,10-tetrahydro- 5H-pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine-5,7(8H)-dione::US10829490, Cmpd # 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472673&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 91971970 441611658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979487 CN1CCN(CC1)c1ccc(Nc2ncc3CCC4N(c3n2)C(C)(C)CNC4=O)nc1 InChI=1S/C22H30N8O/c1-22(2)14-25-20(31)17-6-4-15-12-24-21(27-19(15)30(17)22)26-18-7-5-16(13-23-18)29-10-8-28(3)9-11-29/h5,7,12-13,17H,4,6,8-11,14H2,1-3H3,(H,25,31)(H,23,24,26,27) XBBXTMOEBQDBHN-UHFFFAOYSA-N 472674 10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyridin-2- yl)amino)-6,6a,9,10-tetrahydro- 5H-pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidin-7(8H)-one::US10829490, Cmpd # 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472674&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118451288 441611659 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979490 CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(c3n2)C2(CCCCC2)CNC4=O)nc1 InChI=1S/C25H32N8O2/c1-31-9-11-32(12-10-31)17-5-6-21(26-14-17)29-24-27-15-18-20(34)13-19-23(35)28-16-25(7-3-2-4-8-25)33(19)22(18)30-24/h5-6,14-15,19H,2-4,7-13,16H2,1H3,(H,28,35)(H,26,27,29,30) ZUEUXHMSDWCNAD-UHFFFAOYSA-N 472675 2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-6',6a',8',9'- tetrahydrospiro[cyclohexane-1,10'- pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine1-5',7'-dione::US10829490, Cmpd # 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472675&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118451261 441611660 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979493 CN1CCN(CC1)c1ccc(Nc2ncc3CCC4N(c3n2)C2(CCCCC2)CNC4=O)nc1 InChI=1S/C25H34N8O/c1-31-11-13-32(14-12-31)19-6-8-21(26-16-19)29-24-27-15-18-5-7-20-23(34)28-17-25(9-3-2-4-10-25)33(20)22(18)30-24/h6,8,15-16,20H,2-5,7,9-14,17H2,1H3,(H,28,34)(H,26,27,29,30) RNYWSMGOKRDBKS-UHFFFAOYSA-N 472677 2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-6',6a',8',9'- tetrahydrospiro[cyclohexane-1,10'- pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidin]-7'(5'H)-one::US10829490, Cmpd # 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472677&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118451266 441611662 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979496 CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(c3n2)C2(CCCC2)CNC4=O)nc1 InChI=1S/C24H30N8O2/c1-30-8-10-31(11-9-30)16-4-5-20(25-13-16)28-23-26-14-17-19(33)12-18-22(34)27-15-24(6-2-3-7-24)32(18)21(17)29-23/h4-5,13-14,18H,2-3,6-12,15H2,1H3,(H,27,34)(H,25,26,28,29) NSDIQCPIAXVCSR-UHFFFAOYSA-N 472678 2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-6',6a',8',9'- tetrahydrospiro[cyclopentane- 1,10'- pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine]-5',7'-dione::US10829490, Cmpd # 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472678&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118451284 441611663 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979499 CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(CCNC4=O)c3n2)nc1 InChI=1S/C20H24N8O2/c1-26-6-8-27(9-7-26)13-2-3-17(22-11-13)24-20-23-12-14-16(29)10-15-19(30)21-4-5-28(15)18(14)25-20/h2-3,11-12,15H,4-10H2,1H3,(H,21,30)(H,22,23,24,25) DZTLZHYVLZLORI-UHFFFAOYSA-N 472680 2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-6,6a,9,10- tetrahydro-5H- pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine-5,7(8H)-dione::US10829490, Cmpd # 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472680&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118451280 441611665 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979502 CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4CCCCN4c3n2)nc1 InChI=1S/C21H27N7O/c1-26-8-10-27(11-9-26)16-5-6-19(22-13-16)24-21-23-14-17-18(29)12-15-4-2-3-7-28(15)20(17)25-21/h5-6,13-15H,2-4,7-12H2,1H3,(H,22,23,24,25) MPKVXUVEJFYHOA-UHFFFAOYSA-N 472681 2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)- 6,6a,7,8,9,10-hexahydro-5H- pyrimido[5,4-c]quinolizin-5-one::US10829490, Cmpd # 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472681&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138598470 441611666 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979505 CCOC(=O)C1C2CCCCN2c2nc(Nc3ccc(cn3)N3CCN(C)CC3)ncc2C1=O InChI=1S/C24H31N7O3/c1-3-34-23(33)20-18-6-4-5-9-31(18)22-17(21(20)32)15-26-24(28-22)27-19-8-7-16(14-25-19)30-12-10-29(2)11-13-30/h7-8,14-15,18,20H,3-6,9-13H2,1-2H3,(H,25,26,27,28) CEMBQCFJEVCGEW-UHFFFAOYSA-N 472682 US10829490, Cmpd # 8::ethyl 2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-5-oxo- 6,6a,7,8,9,10-hexahydro-5H- pyrimido[5,4-c]quinolizine-6- carboxylate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472682&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138598469 441611667 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 979508 CN1CCN(CC1)c1ccc(Nc2ncc3C=CC4=NCCC5(CCCCC5)N4c3n2)nc1 InChI=1S/C25H32N8/c1-31-13-15-32(16-14-31)20-6-7-21(27-18-20)29-24-28-17-19-5-8-22-26-12-11-25(9-3-2-4-10-25)33(22)23(19)30-24/h5-8,17-18H,2-4,9-16H2,1H3,(H,27,28,29,30) IQXZJADJLYZGSK-UHFFFAOYSA-N 472683 N-(5-(4-methylpiperazin-1- yl)pyridin-2-yl)-8',9'- dihydrospiro[cyclohexane-1,10'- pyrido[1,6-a:2,3-d']dipyrimidin]- 2'-amine::US10829490, Cmpd # 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 US Patent 10.7270/Q20V8GV8 aid1805008 US10829490 Strum, JC; Jung, D GI Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=472683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=472683&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 138598456 441611668 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51334302 CC[C@H](CO)Nc1nc(NCc2ccccc2)n2ncc(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-18-23-17-16(13(2)3)11-21-25(17)19(24-18)20-10-14-8-6-5-7-9-14/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 SQUNOCMDMIQIQK-OAHLLOKOSA-N 27217 (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol::GP0210::pyrazolo[1,5-a]-1,3,5-triazine, 7a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search NNN 3DOG 25190761 57298927 DB08285 ZINC34285231 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51334306 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 50831668 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51329642 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(C)=O)c3)n2)nc1 InChI=1S/C22H25ClN8O/c1-15(32)26-16-4-3-5-17(12-16)27-21-19(23)14-25-22(29-21)28-20-7-6-18(13-24-20)31-10-8-30(2)9-11-31/h3-7,12-14H,8-11H2,1-2H3,(H,26,32)(H2,24,25,27,28,29) GVJLKAACQAJVQS-UHFFFAOYSA-N 50538150 CHEMBL4647703 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 ChEMBL 10.1021/acs.jmedchem.9b02121 10.7270/Q2N87F9B 32129996 Wang, Y; Chen, X; Yan, Y; Zhu, X; Liu, M; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50538150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50538150&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146047137 442139713 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51328757 O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 50537765 CHEMBL4642944 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2019.111952 10.7270/Q20P13KR 31846828 Zhou, F; Chen, L; Cao, C; Yu, J; Luo, X; Zhou, P; Zhao, L; Du, W; Cheng, J; Xie, Y; Chen, Y Sichuan University and Collaborative Innovation Center of Biotherapy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537765&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145925673 442139328 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333900 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333901 CC(C)(C)c1cnc(CSc2cnc(NC(=O)c3cccc(NC(=O)C=C)c3)s2)o1 InChI=1S/C21H22N4O3S2/c1-5-16(26)24-14-8-6-7-13(9-14)19(27)25-20-23-11-18(30-20)29-12-17-22-10-15(28-17)21(2,3)4/h5-11H,1,12H2,2-4H3,(H,24,26)(H,23,25,27) HMAJGFYNRRZUJX-UHFFFAOYSA-N 50539901 CHEMBL4643057 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539901&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358277 442141464 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333902 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H31N5O4S2/c1-5-21(33)30-19-10-8-17(9-11-19)25(35)32-12-6-7-18(15-32)24(34)31-26-29-14-23(38-26)37-16-22-28-13-20(36-22)27(2,3)4/h5,8-11,13-14,18H,1,6-7,12,15-16H2,2-4H3,(H,30,33)(H,29,31,34) HTFBNTYFTGIOEK-UHFFFAOYSA-N 50539902 CHEMBL4644893 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.8 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539902&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358146 442141465 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333903 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCN(CC3)C(=O)C=C)s2)o1 InChI=1S/C20H26N4O3S2/c1-5-16(25)24-8-6-13(7-9-24)18(26)23-19-22-11-17(29-19)28-12-15-21-10-14(27-15)20(2,3)4/h5,10-11,13H,1,6-9,12H2,2-4H3,(H,22,23,26) WAFHXBBZJZYUIJ-UHFFFAOYSA-N 50539903 CHEMBL4641226 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.2 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539903&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118418553 442141466 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333904 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H31N5O3S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)35-16-22-27-13-20(34-22)26(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32)/t19-/m1/s1 COGUZYALRYMQTD-LJQANCHMSA-N 50539904 CHEMBL4647764 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 114 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539904&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749888 442141467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333905 CC(C)(C)c1cnc(CSc2cnc(N[C@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H31N5O3S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)35-16-22-27-13-20(34-22)26(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32)/t19-/m0/s1 COGUZYALRYMQTD-IBGZPJMESA-N 50539905 CHEMBL4636090 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539905&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749923 442141468 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333906 CC(C)(C)c1cnc(CSc2cnc(NC3CCCC(C3)Nc3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H33N5O2S2/c1-5-22(32)30-18-11-9-17(10-12-18)29-19-7-6-8-20(13-19)31-25-28-15-24(35-25)34-16-23-27-14-21(33-23)26(2,3)4/h5,9-12,14-15,19-20,29H,1,6-8,13,16H2,2-4H3,(H,28,31)(H,30,32) KHUWOOWXQFGVBZ-UHFFFAOYSA-N 50539906 CHEMBL4648005::US11142507, Compound MFH-3-35-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 31 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539906&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358323 442141469 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333907 C[C@@H]1[C@@H](CCCN1C(=O)c1ccc(NC(=O)C=C)cc1)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C27H33N5O3S2/c1-6-22(33)30-19-11-9-18(10-12-19)25(34)32-13-7-8-20(17(32)2)31-26-29-15-24(37-26)36-16-23-28-14-21(35-23)27(3,4)5/h6,9-12,14-15,17,20H,1,7-8,13,16H2,2-5H3,(H,29,31)(H,30,33)/t17-,20-/m1/s1 UYZMRCLCECMQPF-YLJYHZDGSA-N 50539907 CHEMBL4644087 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 257 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539907&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146646288 442141470 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333908 CC(C)(C)c1cnc(CSc2cnc(NC3CN(CC(F)(F)C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H29F2N5O3S2/c1-5-20(34)31-17-8-6-16(7-9-17)23(35)33-13-18(10-26(27,28)15-33)32-24-30-12-22(38-24)37-14-21-29-11-19(36-21)25(2,3)4/h5-9,11-12,18H,1,10,13-15H2,2-4H3,(H,30,32)(H,31,34) GAQVCXTZOSXWPY-UHFFFAOYSA-N 50539908 CHEMBL4636175 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539908&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749962 442141471 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333909 C[C@H]1CC[C@H](CN1C(=O)c1ccc(NC(=O)C=C)cc1)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C27H33N5O3S2/c1-6-22(33)30-19-11-8-18(9-12-19)25(34)32-15-20(10-7-17(32)2)31-26-29-14-24(37-26)36-16-23-28-13-21(35-23)27(3,4)5/h6,8-9,11-14,17,20H,1,7,10,15-16H2,2-5H3,(H,29,31)(H,30,33)/t17-,20+/m0/s1 FPBKUBUKBWJEMH-FXAWDEMLSA-N 50539909 CHEMBL4644643 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539909&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749937 442141472 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333910 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cn3)s2)o1 InChI=1S/C25H30N6O3S2/c1-5-20(32)29-16-8-9-18(26-11-16)23(33)31-10-6-7-17(14-31)30-24-28-13-22(36-24)35-15-21-27-12-19(34-21)25(2,3)4/h5,8-9,11-13,17H,1,6-7,10,14-15H2,2-4H3,(H,28,30)(H,29,32)/t17-/m1/s1 UVGATDDZBKJSAL-QGZVFWFLSA-N 50539910 CHEMBL4645334 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 514 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539910&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358275 442141473 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333911 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)c(F)c3)s2)o1 InChI=1S/C26H30FN5O3S2/c1-5-21(33)31-19-9-8-16(11-18(19)27)24(34)32-10-6-7-17(14-32)30-25-29-13-23(37-25)36-15-22-28-12-20(35-22)26(2,3)4/h5,8-9,11-13,17H,1,6-7,10,14-15H2,2-4H3,(H,29,30)(H,31,33)/t17-/m1/s1 APFZUNBSYNZMFG-QGZVFWFLSA-N 50539911 CHEMBL4644198 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 138 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539911&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146646573 442141474 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333912 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)c(c3)C(F)(F)F)s2)o1 InChI=1S/C27H30F3N5O3S2/c1-5-21(36)34-19-9-8-16(11-18(19)27(28,29)30)24(37)35-10-6-7-17(14-35)33-25-32-13-23(40-25)39-15-22-31-12-20(38-22)26(2,3)4/h5,8-9,11-13,17H,1,6-7,10,14-15H2,2-4H3,(H,32,33)(H,34,36)/t17-/m1/s1 SCNMJGFMXAIFOK-QGZVFWFLSA-N 50539912 CHEMBL4633672 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539912&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156011018 442141475 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333913 C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCc2ccncc2)s1 InChI=1S/C24H25N5O2S2/c1-2-21(30)27-19-7-5-18(6-8-19)23(31)29-13-3-4-20(15-29)28-24-26-14-22(33-24)32-16-17-9-11-25-12-10-17/h2,5-12,14,20H,1,3-4,13,15-16H2,(H,26,28)(H,27,30)/t20-/m1/s1 CYUGBWPMMZVPDP-HXUWFJFHSA-N 50539913 CHEMBL4636908 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539913&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358290 442141476 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333914 FC(F)(F)c1ncc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)cn1 InChI=1S/C24H23F3N6O2S2/c1-2-19(34)31-17-7-5-16(6-8-17)21(35)33-9-3-4-18(13-33)32-23-30-12-20(37-23)36-14-15-10-28-22(29-11-15)24(25,26)27/h2,5-8,10-12,18H,1,3-4,9,13-14H2,(H,30,32)(H,31,34)/t18-/m1/s1 QNQVGWPXBWZBQX-GOSISDBHSA-N 50539914 CHEMBL4637498::US11142507, Compound MFH-3-201-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539914&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358263 442141477 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333915 C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCC2CCOCC2)s1 InChI=1S/C24H30N4O3S2/c1-2-21(29)26-19-7-5-18(6-8-19)23(30)28-11-3-4-20(15-28)27-24-25-14-22(33-24)32-16-17-9-12-31-13-10-17/h2,5-8,14,17,20H,1,3-4,9-13,15-16H2,(H,25,27)(H,26,29)/t20-/m1/s1 XPTUNGFRXJHQJG-HXUWFJFHSA-N 50539915 CHEMBL4643754::US11142507, Compound MFH-4-4-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539915&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749966 442141478 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333916 CC(C)(C)c1cnc(CCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H33N5O3S/c1-5-23(33)30-19-10-8-18(9-11-19)25(34)32-14-6-7-20(17-32)31-26-29-15-21(36-26)12-13-24-28-16-22(35-24)27(2,3)4/h5,8-11,15-16,20H,1,6-7,12-14,17H2,2-4H3,(H,29,31)(H,30,33)/t20-/m1/s1 NXZXWOASWYOLBZ-HXUWFJFHSA-N 50539916 CHEMBL4636251::US11142507, Compound MFH-3-116-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539916&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126673128 442141479 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333917 CC(C)(C)c1cnc(COCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H33N5O4S/c1-5-23(33)30-19-10-8-18(9-11-19)25(34)32-12-6-7-20(15-32)31-26-29-13-21(37-26)16-35-17-24-28-14-22(36-24)27(2,3)4/h5,8-11,13-14,20H,1,6-7,12,15-17H2,2-4H3,(H,29,31)(H,30,33)/t20-/m1/s1 YPSQOIGPBAPUFM-HXUWFJFHSA-N 50539917 CHEMBL4634832::US11142507, Compound MFH-3-128-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539917&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749947 442141480 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333918 CC(C)(C)c1cnc(CNCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H34N6O3S/c1-5-23(34)31-19-10-8-18(9-11-19)25(35)33-12-6-7-20(17-33)32-26-30-14-21(37-26)13-28-16-24-29-15-22(36-24)27(2,3)4/h5,8-11,14-15,20,28H,1,6-7,12-13,16-17H2,2-4H3,(H,30,32)(H,31,34)/t20-/m1/s1 BULBBWSMORELAY-HXUWFJFHSA-N 50539918 CHEMBL4632815::US11142507, Compound MFH-3-137-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7140 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539918&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749889 442141481 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333919 CC(C)(C)c1cnc(C[S+]([O-])c2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H31N5O4S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)37(34)16-22-27-13-20(35-22)26(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32)/t19-,37?/m1/s1 CCGRMLGTKGCLKM-DEQHTHAUSA-N 50539919 CHEMBL4649546 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9220 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539919&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358369 442141482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333920 CC(C)(C)c1cnc(CSc2nc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)ncc2Cl)o1 InChI=1S/C27H31ClN6O3S/c1-5-22(35)31-18-10-8-17(9-11-18)25(36)34-12-6-7-19(15-34)32-26-30-13-20(28)24(33-26)38-16-23-29-14-21(37-23)27(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,31,35)(H,30,32,33)/t19-/m1/s1 PUZGAVMGSWIMSU-LJQANCHMSA-N 50539920 CHEMBL4645503 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539920&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156019445 442141483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333921 CC(C)(C)c1cnc(CSc2nnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C25H30N6O3S2/c1-5-20(32)27-17-10-8-16(9-11-17)22(33)31-12-6-7-18(14-31)28-23-29-30-24(36-23)35-15-21-26-13-19(34-21)25(2,3)4/h5,8-11,13,18H,1,6-7,12,14-15H2,2-4H3,(H,27,32)(H,28,29)/t18-/m1/s1 ZGTBRXCHDKWPQT-GOSISDBHSA-N 50539921 CHEMBL4649802::US11142507, Compound MFH-2-25-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539921&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145749881 442141484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51333922 Cc1nc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)sc1SCc1ncc(o1)C(C)(C)C InChI=1S/C27H33N5O3S2/c1-6-22(33)30-19-11-9-18(10-12-19)24(34)32-13-7-8-20(15-32)31-26-29-17(2)25(37-26)36-16-23-28-14-21(35-23)27(3,4)5/h6,9-12,14,20H,1,7-8,13,15-16H2,2-5H3,(H,29,31)(H,30,33)/t20-/m1/s1 LXESGOTXIVUNEN-HXUWFJFHSA-N 50539922 CHEMBL4636655 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2870 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539922&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137358102 442141485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51340059 O=C1\C(CCc2ccccc12)=C\c1c[nH]c2ncccc12 InChI=1S/C18H14N2O/c21-17-13(8-7-12-4-1-2-5-15(12)17)10-14-11-20-18-16(14)6-3-9-19-18/h1-6,9-11H,7-8H2,(H,19,20)/b13-10+ PDGDTQLLJKBTHW-JLHYYAGUSA-N 50542438 CHEMBL4647459 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 424 ChEMBL 10.1016/j.bmc.2020.115468 10.7270/Q28G8Q87 32284225 Qhobosheane, MA; Legoabe, LJ; Josselin, B; Bach, S; Ruchaud, S; Petzer, JP; Beteck, RM North-West University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50542438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50542438&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156021481 442144001 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51340060 Oc1ccc2C(=O)\C(CCc2c1)=C\c1c[nH]c2ncccc12 InChI=1S/C18H14N2O2/c21-14-5-6-15-11(9-14)3-4-12(17(15)22)8-13-10-20-18-16(13)2-1-7-19-18/h1-2,5-10,21H,3-4H2,(H,19,20)/b12-8+ NBJYPTQHFDBQQA-XYOKQWHBSA-N 50542439 CHEMBL4637707 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 495 ChEMBL 10.1016/j.bmc.2020.115468 10.7270/Q28G8Q87 32284225 Qhobosheane, MA; Legoabe, LJ; Josselin, B; Bach, S; Ruchaud, S; Petzer, JP; Beteck, RM North-West University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50542439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50542439&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156011177 442144002 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1083681 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 111 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1083682 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCC(C)n5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-3-36-9-11-37(12-10-36)17-19-7-8-24(31-15-19)33-28-32-16-22(30)26(35-28)20-13-21(29)27-23(14-20)38-18(2)5-4-6-25(38)34-27/h7-8,13-16,18H,3-6,9-12,17H2,1-2H3,(H,31,32,33,35) XOJPAVACYRFOBK-UHFFFAOYSA-N 515905 N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl)-5- fluoro-4-(6- fluoro-1-methyl- 1,2,3,4-tetrahydrobenzo [4,5]imidazo[l,2- a]pyridin- 8-yl)pyrimidin-2-amine::US11053238, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 572 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=515905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=515905&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135181567 461601990 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1083683 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCCCn4c3c2)nc1 InChI=1S/C25H26F2N8/c1-33-8-10-34(11-9-33)17-5-6-21(28-14-17)30-25-29-15-19(27)23(32-25)16-12-18(26)24-20(13-16)35-7-3-2-4-22(35)31-24/h5-6,12-15H,2-4,7-11H2,1H3,(H,28,29,30,32) DIFUHKJZJNRRMN-UHFFFAOYSA-N 516039 US11053238, Compound 2a::US11053238, Compound 2b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 779 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516039&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135181734 461602122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1083684 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCCCn4c3c2)nc1 InChI=1S/C25H26F2N8/c1-33-8-10-34(11-9-33)17-5-6-21(28-14-17)30-25-29-15-19(27)23(32-25)16-12-18(26)24-20(13-16)35-7-3-2-4-22(35)31-24/h5-6,12-15H,2-4,7-11H2,1H3,(H,28,29,30,32) DIFUHKJZJNRRMN-UHFFFAOYSA-N 516039 US11053238, Compound 2a::US11053238, Compound 2b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 649 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516039&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135181734 461602122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51382905 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.8 ChEMBL 10.1016/j.bmc.2018.02.022 10.7270/Q2DJ5KB8 29523467 Hou, W; Ren, Y; Zhang, Z; Sun, H; Ma, Y; Yan, B Beijing Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51395898 CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4NCCCOc34)cc2)no1 InChI=1S/C21H25N7O3/c1-21(2,3)15-11-16(28-31-15)27-20(29)26-14-7-5-13(6-8-14)25-19-17-18(23-12-24-19)22-9-4-10-30-17/h5-8,11-12H,4,9-10H2,1-3H3,(H2,22,23,24,25)(H2,26,27,28,29) WPXVVAWAHQHJPF-UHFFFAOYSA-N 50563891 CHEMBL4793380 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 833 ChEMBL 10.1016/j.ejmech.2017.09.018 10.7270/Q270854P 29133048 Yang, J; Chen, K; Zhang, G; Yang, QY; Li, YS; Huang, SZ; Wang, YL; Yang, W; Jiang, XJ; Yan, HX; Zhu, JQ; Xiang, R; Luo, YF; Li, WM; Wei, YQ; Li, LL; Yang, SY Sichuan University/Collaborative Innovation Center of Biotherapy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563891&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162673880 461684229 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51393854 Clc1cncc(-c2cc3ccccc3o2)c1N1CCC2(CCNC2=O)CC1 InChI=1S/C21H20ClN3O2/c22-16-13-23-12-15(18-11-14-3-1-2-4-17(14)27-18)19(16)25-9-6-21(7-10-25)5-8-24-20(21)26/h1-4,11-13H,5-10H2,(H,24,26) ILMHDRGZABQLEW-UHFFFAOYSA-N 50563322 CHEMBL4777349 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1765 ChEMBL 10.1016/j.ejmech.2021.113248 10.7270/Q2930XW8 33571827 Yu, M; Teo, T; Yang, Y; Li, M; Long, Y; Philip, S; Noll, B; Heinemann, GK; Diab, S; Eldi, P; Mekonnen, L; Anshabo, AT; Rahaman, MH; Milne, R; Hayball, JD; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563322&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162643699 461683660 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51394349 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2021.113281 10.7270/Q2TX3K3W 33611192 Lin, T; Li, J; Liu, L; Li, Y; Jiang, H; Chen, K; Xu, P; Luo, C; Zhou, B ShanghaiTech University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51394350 NC(=O)c1ccc(cn1)-c1ccc(F)c(C(=O)Nc2c[nH]nc2C(=O)Nc2ccc(F)cc2)c1F InChI=1S/C23H15F3N6O3/c24-12-2-4-13(5-3-12)30-23(35)20-17(10-29-32-20)31-22(34)18-15(25)7-6-14(19(18)26)11-1-8-16(21(27)33)28-9-11/h1-10H,(H2,27,33)(H,29,32)(H,30,35)(H,31,34) JNYWLVWHCGXRPJ-UHFFFAOYSA-N 50563486 CHEMBL4757951 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1119 ChEMBL 10.1016/j.ejmech.2021.113281 10.7270/Q2TX3K3W 33611192 Lin, T; Li, J; Liu, L; Li, Y; Jiang, H; Chen, K; Xu, P; Luo, C; Zhou, B ShanghaiTech University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563486&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162657070 461683824 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51394357 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10.0 ChEMBL 10.1016/j.ejmech.2021.113281 10.7270/Q2TX3K3W 33611192 Lin, T; Li, J; Liu, L; Li, Y; Jiang, H; Chen, K; Xu, P; Luo, C; Zhou, B ShanghaiTech University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51394375 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10.0 ChEMBL 10.1016/j.ejmech.2021.113281 10.7270/Q2TX3K3W 33611192 Lin, T; Li, J; Liu, L; Li, Y; Jiang, H; Chen, K; Xu, P; Luo, C; Zhou, B ShanghaiTech University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51395067 O=c1[nH]cc(C2CCCCC2)c2nccn12 InChI=1S/C12H15N3O/c16-12-14-8-10(9-4-2-1-3-5-9)11-13-6-7-15(11)12/h6-9H,1-5H2,(H,14,16) IRDDESQGXYVSBF-UHFFFAOYSA-N 50563675 CHEMBL4762791 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10000 ChEMBL 10.1016/j.ejmech.2021.113309 10.7270/Q29027J7 33711765 Jansa, J; Jorda, R; Škerlová, J; Pachl, P; Peřina, M; Řezníčková, E; Heger, T; Gucký, T; Řezáčová, P; Lyčka, A; Kryštof, V Institute for Organic Syntheses (VUOS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563675&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search R7B 7ACK 155818890 461684013 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51395068 NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3nc[nH]c3n2)cc1 InChI=1S/C23H18N6O2S/c24-32(30,31)19-11-9-18(10-12-19)27-23-28-20(21-22(29-23)26-14-25-21)17-8-4-7-16(13-17)15-5-2-1-3-6-15/h1-14H,(H2,24,30,31)(H2,25,26,27,28,29) FUGRWXRQJGJIER-UHFFFAOYSA-N 50235334 CHEMBL4070391 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9400 ChEMBL 10.1016/j.ejmech.2021.113309 10.7270/Q29027J7 33711765 Jansa, J; Jorda, R; Škerlová, J; Pachl, P; Peřina, M; Řezníčková, E; Heger, T; Gucký, T; Řezáčová, P; Lyčka, A; Kryštof, V Institute for Organic Syntheses (VUOS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 123132899 384991208 CHEMBL4070391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51389575 Nc1nc(N[C@H]2C[C@@H]3CC[C@H]2C3)sc1C(=O)c1ccccc1[N+]([O-])=O InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9-,10+,12+/m1/s1 JRNXAQINDCOHGS-SCVCMEIPSA-N 50561527 CHEMBL4764481 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1021/acsmedchemlett.0c00006 10.7270/Q28W3J0T 33062159 Childers, WE; Elokely, KM; Abou-Gharbia, M Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search TO7 6W9E 137333456 461831919 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51368998 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <4.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369003 CN1CC[C@H]([C@@H]1CO)c1c(OP(O)(O)=O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H21ClNO8P/c1-23-7-6-12(14(23)10-24)19-18(31-32(27,28)29)9-16(26)20-15(25)8-17(30-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24,26H,6-7,10H2,1H3,(H2,27,28,29)/t12-,14+/m1/s1 LXRJNNLNUWGVCX-OCCSQVGLSA-N 50553485 CHEMBL4790952 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553485&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162670662 461692253 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369016 Nc1nccc(n1)-c1c2cccnc2n2c(N)nccc12 InChI=1S/C14H11N7/c15-13-18-6-3-9(20-13)11-8-2-1-5-17-12(8)21-10(11)4-7-19-14(21)16/h1-7H,(H2,16,19)(H2,15,18,20) JTQQDEMYPLKSDW-UHFFFAOYSA-N 50553487 CHEMBL4740353 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <40 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553487&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 9860424 461692255 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369017 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1 InChI=1S/C17H16FN5O3S/c1-26-15-8-12(18)5-6-14(15)16-20-10-21-17(23-16)22-13-4-2-3-11(7-13)9-27(19,24)25/h2-8,10H,9H2,1H3,(H2,19,24,25)(H,20,21,22,23) MGCPJSMHKDVTGW-UHFFFAOYSA-N 50553488 CHEMBL4743691 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553488&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 53491924 461692256 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369018 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=O)c2)n1 InChI=1S/C18H17FN4O3S/c1-26-16-9-13(19)6-7-15(16)17-20-11-21-18(23-17)22-14-5-3-4-12(8-14)10-27(2,24)25/h3-9,11H,10H2,1-2H3,(H,20,21,22,23) SIZCGYPBEMJYPU-UHFFFAOYSA-N 50553489 CHEMBL4742789 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553489&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66576206 461692257 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369019 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CCS(C)(=O)=O)c2)n1 InChI=1S/C19H19FN4O3S/c1-27-17-11-14(20)6-7-16(17)18-21-12-22-19(24-18)23-15-5-3-4-13(10-15)8-9-28(2,25)26/h3-7,10-12H,8-9H2,1-2H3,(H,21,22,23,24) YOSZIAPYUKGCMJ-UHFFFAOYSA-N 50553490 CHEMBL4789982 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553490&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162669360 461692258 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369020 COc1cc(F)ccc1-c1ncnc(Nc2cccc(c2)S(C)(=O)=O)n1 InChI=1S/C17H15FN4O3S/c1-25-15-8-11(18)6-7-14(15)16-19-10-20-17(22-16)21-12-4-3-5-13(9-12)26(2,23)24/h3-10H,1-2H3,(H,19,20,21,22) PPJCWIBZYANFBE-UHFFFAOYSA-N 50553491 CHEMBL4756226 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553491&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162656009 461692259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369021 CS(=N)(=N)Cc1cc2Nc3ncc(F)c(n3)-c3ccc(F)cc3OCCCCOc(c1)c2 InChI=1S/C22H23F2N5O2S/c1-32(25,26)13-14-8-16-11-17(9-14)30-6-2-3-7-31-20-10-15(23)4-5-18(20)21-19(24)12-27-22(28-16)29-21/h4-5,8-12,25-26H,2-3,6-7,13H2,1H3,(H,27,28,29) HASNZZTVQOLZGN-UHFFFAOYSA-N 50553492 CHEMBL4743292 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.1 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553492&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135336050 461692260 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369022 CS(=N)(=N)Cc1cc2Nc3ncc(F)c(n3)-c3cccc(F)c3OCCCCOc(c1)c2 InChI=1S/C22H23F2N5O2S/c1-32(25,26)13-14-9-15-11-16(10-14)30-7-2-3-8-31-21-17(5-4-6-18(21)23)20-19(24)12-27-22(28-15)29-20/h4-6,9-12,25-26H,2-3,7-8,13H2,1H3,(H,27,28,29) DBOXIXXMMCQDIQ-UHFFFAOYSA-N 50553493 CHEMBL4752000 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.4 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553493&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135283319 461692261 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369023 Cc1cc(CS(C)(=O)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)c3ccoc23)c1 InChI=1S/C21H17F2N3O3S/c1-12-7-13(11-30(2,27)28)9-14(8-12)25-21-24-10-18(23)19(26-21)16-3-4-17(22)15-5-6-29-20(15)16/h3-10H,11H2,1-2H3,(H,24,25,26) AULDUFVLZQNYJD-UHFFFAOYSA-N 50553494 CHEMBL4764625 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553494&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 121284390 461692262 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369030 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) ACWKGTGIJRCOOM-UHFFFAOYSA-N 168383 US9669034, 2 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618220 373987116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369039 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <3.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369044 COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m0/s1 XWQVQSXLXAXOPJ-ACRUOGEOSA-N 50553495 CHEMBL4786559 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <0.500000 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553495&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 68276369 461692263 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369064 COc1ccc(F)cc1-c1ncnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C18H19FN4O/c1-24-16-3-2-12(19)8-13(16)17-14-9-15(11-4-6-20-7-5-11)23-18(14)22-10-21-17/h2-3,8-11,20H,4-7H2,1H3,(H,21,22,23) CQXQTPQYKDPBDR-UHFFFAOYSA-N 50553496 CHEMBL4788036 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553496&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 86271754 461692264 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369065 Clc1cnc(NC(=O)[C@H]2CNCCO2)cc1-c1cc(NCC2CCOCC2)cnc1Cl InChI=1S/C21H25Cl2N5O3/c22-17-11-26-19(28-21(29)18-12-24-3-6-31-18)8-15(17)16-7-14(10-27-20(16)23)25-9-13-1-4-30-5-2-13/h7-8,10-11,13,18,24-25H,1-6,9,12H2,(H,26,28,29)/t18-/m1/s1 AMMBWNGMXHWBAS-GOSISDBHSA-N 50553497 CHEMBL4753804 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553497&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 60142176 461692265 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369066 Fc1cccc(CNc2cccc(n2)-c2cc(NC(=O)[C@H]3CNCCO3)ncc2Cl)c1 InChI=1S/C22H21ClFN5O2/c23-17-12-27-21(29-22(30)19-13-25-7-8-31-19)10-16(17)18-5-2-6-20(28-18)26-11-14-3-1-4-15(24)9-14/h1-6,9-10,12,19,25H,7-8,11,13H2,(H,26,28)(H,27,29,30)/t19-/m1/s1 FLOFPILSSAJAMS-LJQANCHMSA-N 50553498 CHEMBL4782011 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <8.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553498&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162664142 461692266 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369068 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51369069 CN1CC[C@H]([C@@H]1CO)c1c(OP(O)(O)=O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1Cl)C(F)(F)F InChI=1S/C22H20ClF3NO8P/c1-27-5-4-12(14(27)9-28)19-18(35-36(31,32)33)8-16(30)20-15(29)7-17(34-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28,30H,4-5,9H2,1H3,(H2,31,32,33)/t12-,14+/m1/s1 WLTRIWCDHOZNRP-OCCSQVGLSA-N 50553486 CHEMBL4782409 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.7 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553486&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162664628 461692254 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375032 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)[S@](=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29+/m1/s1 UELYDGOOJPRWGF-SRQXXRKNSA-N 50468265 CHEMBL4282338 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50468265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50468265&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 71494949 433935530 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375041 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1 InChI=1S/C17H16FN5O3S/c1-26-15-8-12(18)5-6-14(15)16-20-10-21-17(23-16)22-13-4-2-3-11(7-13)9-27(19,24)25/h2-8,10H,9H2,1H3,(H2,19,24,25)(H,20,21,22,23) MGCPJSMHKDVTGW-UHFFFAOYSA-N 50553488 CHEMBL4743691 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553488&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 53491924 461692256 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375042 COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@](C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24)/t27-/m1/s1 ACWKGTGIJRCOOM-HHHXNRCGSA-N 50528818 CHEMBL4439321 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 121488167 440737400 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375043 COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(C)(=N)=O)c2)ncc1F InChI=1S/C19H17F3N4O2S/c1-28-17-8-12(20)3-4-15(17)18-16(22)9-24-19(26-18)25-14-6-11(5-13(21)7-14)10-29(2,23)27/h3-9,23H,10H2,1-2H3,(H,24,25,26) NSJOYQIOHVHMCZ-UHFFFAOYSA-N 180805 US9133171, 10::US9133171, 15::US9133171, 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 37 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=180805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=180805&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71515731 313362966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375044 COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(C)(=N)=N)c2)ncc1F InChI=1S/C19H18F3N5OS/c1-28-17-8-12(20)3-4-15(17)18-16(22)9-25-19(27-18)26-14-6-11(5-13(21)7-14)10-29(2,23)24/h3-9,23-24H,10H2,1-2H3,(H,25,26,27) UGRBYBMJRWTFTG-UHFFFAOYSA-N 50556033 CHEMBL4793497 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 104 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556033&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118419634 461694801 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375045 COc1cc(F)ccc1-c1cc(Nc2cc(C[S@@](C)(=N)=O)ccn2)ncc1F InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)/t28-/m0/s1 YZCUMZWULWOUMD-NDEPHWFRSA-N 50556034 CHEMBL4762845 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556034&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139593425 461694802 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51375046 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=O)c2)n1 InChI=1S/C18H17FN4O3S/c1-26-16-9-13(19)6-7-15(16)17-20-11-21-18(23-17)22-14-5-3-4-12(8-14)10-27(2,24)25/h3-9,11H,10H2,1-2H3,(H,20,21,22,23) SIZCGYPBEMJYPU-UHFFFAOYSA-N 50553489 CHEMBL4742789 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.0c00960 10.7270/Q29W0K46 32870008 Mäder, P; Kattner, L Endotherm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553489&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66576206 461692257 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359506 CN1CCN(CC1)c1ccc(Nc2ncc3CC4(CC(=O)NC4=O)N(C4CCCC4)c3n2)cc1F InChI=1S/C25H30FN7O2/c1-31-8-10-32(11-9-31)20-7-6-17(12-19(20)26)28-24-27-15-16-13-25(14-21(34)29-23(25)35)33(22(16)30-24)18-4-2-3-5-18/h6-7,12,15,18H,2-5,8-11,13-14H2,1H3,(H,27,28,30)(H,29,34,35) JHWGNERNOFJTIU-UHFFFAOYSA-N 50549728 CHEMBL4785428 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549728&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153631215 461680068 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359507 CN1CCN(CC1)c1ccc(Nc2ncc3CC4(CCNC4=O)N(C4CCCC4)c3n2)cc1F InChI=1S/C25H32FN7O/c1-31-10-12-32(13-11-31)21-7-6-18(14-20(21)26)29-24-28-16-17-15-25(8-9-27-23(25)34)33(22(17)30-24)19-4-2-3-5-19/h6-7,14,16,19H,2-5,8-13,15H2,1H3,(H,27,34)(H,28,29,30) HFPVKHFOWKBZPW-UHFFFAOYSA-N 50549729 CHEMBL4776293 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549729&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153631059 461680069 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359508 CN1CCN(CC1)c1ccc(Nc2ncc3CC4(CC(=O)NC4=O)N(C4CCCC4)c3n2)cc1 InChI=1S/C25H31N7O2/c1-30-10-12-31(13-11-30)19-8-6-18(7-9-19)27-24-26-16-17-14-25(15-21(33)28-23(25)34)32(22(17)29-24)20-4-2-3-5-20/h6-9,16,20H,2-5,10-15H2,1H3,(H,26,27,29)(H,28,33,34) GRXZKZDEMVGHOD-UHFFFAOYSA-N 50549730 CHEMBL4742131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 81 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549730&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153631251 461680070 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359509 CC(C)N1CCN(CC1)c1ccc(Nc2ncc3CC4(CC(=O)NC4=O)N(C4CCCC4)c3n2)cc1 InChI=1S/C27H35N7O2/c1-18(2)32-11-13-33(14-12-32)21-9-7-20(8-10-21)29-26-28-17-19-15-27(16-23(35)30-25(27)36)34(24(19)31-26)22-5-3-4-6-22/h7-10,17-18,22H,3-6,11-16H2,1-2H3,(H,28,29,31)(H,30,35,36) WDVONLZSOJVUBM-UHFFFAOYSA-N 50549731 CHEMBL4796549 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549731&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153631396 461680071 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359510 CN(C)CCN(C)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)cc1 InChI=1S/C26H34N6O2/c1-17-22-16-27-26(28-19-10-12-20(13-11-19)31(5)15-14-30(3)4)29-24(22)32(21-8-6-7-9-21)25(34)23(17)18(2)33/h10-13,16,21H,6-9,14-15H2,1-5H3,(H,27,28,29) RKVDTLGPDOTLOS-UHFFFAOYSA-N 50549732 CHEMBL4787666 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.1 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549732&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630724 461680072 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359511 CN(C)CCN(C)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(c3n2)C23CC(C2)C3)cc1 InChI=1S/C26H32N6O2/c1-16-21-15-27-25(28-19-6-8-20(9-7-19)31(5)11-10-30(3)4)29-23(21)32(24(34)22(16)17(2)33)26-12-18(13-26)14-26/h6-9,15,18H,10-14H2,1-5H3,(H,27,28,29) NTYNHLNPPJSNGN-UHFFFAOYSA-N 50549733 CHEMBL4759094 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 149 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549733&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630847 461680073 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359512 CC1CN(CC(C)N1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)cc1 InChI=1S/C27H34N6O2/c1-16-14-32(15-17(2)29-16)21-11-9-20(10-12-21)30-27-28-13-23-18(3)24(19(4)34)26(35)33(25(23)31-27)22-7-5-6-8-22/h9-13,16-17,22,29H,5-8,14-15H2,1-4H3,(H,28,30,31) DLCSOVFRLIMWJH-UHFFFAOYSA-N 50549734 CHEMBL3958430 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549734&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134154740 461680074 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359513 CN(C)CCOc1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)cc1F InChI=1S/C25H30FN5O3/c1-15-19-14-27-25(28-17-9-10-21(20(26)13-17)34-12-11-30(3)4)29-23(19)31(18-7-5-6-8-18)24(33)22(15)16(2)32/h9-10,13-14,18H,5-8,11-12H2,1-4H3,(H,27,28,29) GBVXPZRKGCHAIL-UHFFFAOYSA-N 50549735 CHEMBL4796706 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549735&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630905 461680075 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359514 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc2n1C12CC(C1)C2 InChI=1S/C24H28FN7O/c1-30(2)22(33)20-9-16-14-27-23(29-21(16)32(20)24-11-15(12-24)13-24)28-17-3-4-19(18(25)10-17)31-7-5-26-6-8-31/h3-4,9-10,14-15,26H,5-8,11-13H2,1-2H3,(H,27,28,29) ICHOXUPNGQKPQR-UHFFFAOYSA-N 50549736 CHEMBL4743130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.2 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549736&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630459 461680076 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359515 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(CCO)CC4)c(F)c3)nc2n1C12CC(C1)C2 InChI=1S/C26H32FN7O2/c1-31(2)24(36)22-11-18-16-28-25(30-23(18)34(22)26-13-17(14-26)15-26)29-19-3-4-21(20(27)12-19)33-7-5-32(6-8-33)9-10-35/h3-4,11-12,16-17,35H,5-10,13-15H2,1-2H3,(H,28,29,30) QOUGGDPQABJLGQ-UHFFFAOYSA-N 50549737 CHEMBL4745518 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <3.2 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549737&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630524 461680077 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359516 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCC(CC4)N4CCN(C)CC4)c(F)c3)nc2n1C12CC(C1)C2 InChI=1S/C30H39FN8O/c1-35(2)28(40)26-14-21-19-32-29(34-27(21)39(26)30-16-20(17-30)18-30)33-22-4-5-25(24(31)15-22)38-8-6-23(7-9-38)37-12-10-36(3)11-13-37/h4-5,14-15,19-20,23H,6-13,16-18H2,1-3H3,(H,32,33,34) FQJOSTDUDYQMRQ-UHFFFAOYSA-N 50549738 CHEMBL4797439 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.6 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549738&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630355 461680078 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51359517 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2n1C12CC(C1)C2 InChI=1S/C25H31N7O/c1-29(2)23(33)21-12-18-16-26-24(28-22(18)32(21)25-13-17(14-25)15-25)27-19-4-6-20(7-5-19)31-10-8-30(3)9-11-31/h4-7,12,16-17H,8-11,13-15H2,1-3H3,(H,26,27,28) LUNQSGPHDRPPNB-UHFFFAOYSA-N 50549739 CHEMBL4742853 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.1 ChEMBL 10.1021/acsmedchemlett.0c00635 10.7270/Q2J96B03 33488958 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549739&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153630589 461680079 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363515 Nc1n[nH]c(N)c1\N=N\c1ccc(cc1)S(N)(=O)=O InChI=1S/C9H11N7O2S/c10-8-7(9(11)16-15-8)14-13-5-1-3-6(4-2-5)19(12,17)18/h1-4H,(H2,12,17,18)(H5,10,11,15,16)/b14-13+ XLIZDMWIBNVIPS-BUHFOSPRSA-N 50343660 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)benzenesulfonamide::CHEMBL1775075 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343660&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 5869730 131346596 CHEMBL1775075 ZINC04657707 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363516 Nc1nn2cc([nH]c2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C17H15N7O2S/c18-16-15(22-21-12-6-8-13(9-7-12)27(19,25)26)17-20-14(10-24(17)23-16)11-4-2-1-3-5-11/h1-10,20H,(H2,18,23)(H2,19,25,26)/b22-21+ VEZCKOCJJKFUQH-QURGRASLSA-N 50551102 CHEMBL4783101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >25000 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551102&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394959 461681442 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363517 Cc1ccc(cc1)-c1cn2nc(N)c(\N=N\c3ccc(cc3)S(N)(=O)=O)c2[nH]1 InChI=1S/C18H17N7O2S/c1-11-2-4-12(5-3-11)15-10-25-18(21-15)16(17(19)24-25)23-22-13-6-8-14(9-7-13)28(20,26)27/h2-10,21H,1H3,(H2,19,24)(H2,20,26,27)/b23-22+ AKCOMXHKFLHYDN-GHVJWSGMSA-N 50551103 CHEMBL4784840 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551103&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395495 461681443 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363518 Nc1nn2cc([nH]c2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(F)cc1 InChI=1S/C17H14FN7O2S/c18-11-3-1-10(2-4-11)14-9-25-17(21-14)15(16(19)24-25)23-22-12-5-7-13(8-6-12)28(20,26)27/h1-9,21H,(H2,19,24)(H2,20,26,27)/b23-22+ JAKROTJQYVKKBP-GHVJWSGMSA-N 50551104 CHEMBL4785207 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551104&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395483 461681444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363519 Nc1nn2cc([nH]c2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 InChI=1S/C17H14ClN7O2S/c18-11-3-1-10(2-4-11)14-9-25-17(21-14)15(16(19)24-25)23-22-12-5-7-13(8-6-12)28(20,26)27/h1-9,21H,(H2,19,24)(H2,20,26,27)/b23-22+ KBRGTQDAHIIWBV-GHVJWSGMSA-N 50551105 CHEMBL4747175 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551105&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394960 461681445 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363520 Nc1nn2cc([nH]c2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(Br)cc1 InChI=1S/C17H14BrN7O2S/c18-11-3-1-10(2-4-11)14-9-25-17(21-14)15(16(19)24-25)23-22-12-5-7-13(8-6-12)28(20,26)27/h1-9,21H,(H2,19,24)(H2,20,26,27)/b23-22+ XQQUUIQYQFCYDD-GHVJWSGMSA-N 50551106 CHEMBL4747600 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551106&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394807 461681446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363521 Nc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C18H15N7O2S/c19-17-16(23-22-13-6-8-14(9-7-13)28(20,26)27)18-21-11-10-15(25(18)24-17)12-4-2-1-3-5-12/h1-11H,(H2,19,24)(H2,20,26,27)/b23-22+ QOOYRRCOJRNTCR-GHVJWSGMSA-N 50551107 CHEMBL4760748 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551107&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394972 461681447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363522 Cc1ccc(cc1)-c1ccnc2c(\N=N\c3ccc(cc3)S(N)(=O)=O)c(N)nn12 InChI=1S/C19H17N7O2S/c1-12-2-4-13(5-3-12)16-10-11-22-19-17(18(20)25-26(16)19)24-23-14-6-8-15(9-7-14)29(21,27)28/h2-11H,1H3,(H2,20,25)(H2,21,27,28)/b24-23+ KJDLSZXXWPOVFP-WCWDXBQESA-N 50551108 CHEMBL4758858 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551108&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395320 461681448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363523 Nc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(F)cc1 InChI=1S/C18H14FN7O2S/c19-12-3-1-11(2-4-12)15-9-10-22-18-16(17(20)25-26(15)18)24-23-13-5-7-14(8-6-13)29(21,27)28/h1-10H,(H2,20,25)(H2,21,27,28)/b24-23+ PEGVFQMGKHGCER-WCWDXBQESA-N 50551109 CHEMBL4790806 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551109&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394808 461681449 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363524 Nc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 InChI=1S/C18H14ClN7O2S/c19-12-3-1-11(2-4-12)15-9-10-22-18-16(17(20)25-26(15)18)24-23-13-5-7-14(8-6-13)29(21,27)28/h1-10H,(H2,20,25)(H2,21,27,28)/b24-23+ ANPPRZRKIIVFGL-WCWDXBQESA-N 50551110 CHEMBL4798487 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551110&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395828 461681450 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363525 Nc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(Br)cc1 InChI=1S/C18H14BrN7O2S/c19-12-3-1-11(2-4-12)15-9-10-22-18-16(17(20)25-26(15)18)24-23-13-5-7-14(8-6-13)29(21,27)28/h1-10H,(H2,20,25)(H2,21,27,28)/b24-23+ VPJWECUQRFSGFO-WCWDXBQESA-N 50551111 CHEMBL4780776 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551111&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395329 461681451 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363526 COc1ccc(cc1)-c1ccnc2c(\N=N\c3ccc(cc3)S(N)(=O)=O)c(N)nn12 InChI=1S/C19H17N7O3S/c1-29-14-6-2-12(3-7-14)16-10-11-22-19-17(18(20)25-26(16)19)24-23-13-4-8-15(9-5-13)30(21,27)28/h2-11H,1H3,(H2,20,25)(H2,21,27,28)/b24-23+ BMZCHLZLVYKQMW-WCWDXBQESA-N 50551112 CHEMBL4751980 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551112&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162396021 461681452 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363527 Nc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C18H14N8O4S/c19-17-16(23-22-12-3-7-14(8-4-12)31(20,29)30)18-21-10-9-15(25(18)24-17)11-1-5-13(6-2-11)26(27)28/h1-10H,(H2,19,24)(H2,20,29,30)/b23-22+ XEDPDGPVDPXHDH-GHVJWSGMSA-N 50551113 CHEMBL4790351 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551113&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395485 461681453 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363528 Nc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1cccs1 InChI=1S/C16H13N7O2S2/c17-15-14(21-20-10-3-5-11(6-4-10)27(18,24)25)16-19-8-7-12(23(16)22-15)13-2-1-9-26-13/h1-9H,(H2,17,22)(H2,18,24,25)/b21-20+ TWLBRDPBOUDNES-QZQOTICOSA-N 50551114 CHEMBL4762561 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551114&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162396022 461681454 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363529 Nc1nn2c(N)c(C#N)c(nc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C19H15N9O2S/c20-10-14-15(11-4-2-1-3-5-11)24-19-16(17(21)27-28(19)18(14)22)26-25-12-6-8-13(9-7-12)31(23,29)30/h1-9H,22H2,(H2,21,27)(H2,23,29,30)/b26-25+ CCJFFHRRJCAICV-OCEACIFDSA-N 50551115 CHEMBL4741899 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551115&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394965 461681455 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363530 Cc1ccc(cc1)-c1nc2c(\N=N\c3ccc(cc3)S(N)(=O)=O)c(N)nn2c(N)c1C#N InChI=1S/C20H17N9O2S/c1-11-2-4-12(5-3-11)16-15(10-21)19(23)29-20(25-16)17(18(22)28-29)27-26-13-6-8-14(9-7-13)32(24,30)31/h2-9H,23H2,1H3,(H2,22,28)(H2,24,30,31)/b27-26+ XIEZNUNKXXLJEK-CYYJNZCTSA-N 50551116 CHEMBL4747714 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551116&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162396011 461681456 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363531 Nc1nn2c(N)c(C#N)c(nc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(F)cc1 InChI=1S/C19H14FN9O2S/c20-11-3-1-10(2-4-11)15-14(9-21)18(23)29-19(25-15)16(17(22)28-29)27-26-12-5-7-13(8-6-12)32(24,30)31/h1-8H,23H2,(H2,22,28)(H2,24,30,31)/b27-26+ BAJIXIUEAFCSGI-CYYJNZCTSA-N 50551117 CHEMBL4786073 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551117&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162394809 461681457 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363532 Nc1nn2c(N)c(C#N)c(nc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 InChI=1S/C19H14ClN9O2S/c20-11-3-1-10(2-4-11)15-14(9-21)18(23)29-19(25-15)16(17(22)28-29)27-26-12-5-7-13(8-6-12)32(24,30)31/h1-8H,23H2,(H2,22,28)(H2,24,30,31)/b27-26+ MMQUJAWFSZRIKT-CYYJNZCTSA-N 50551118 CHEMBL4741017 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551118&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162396019 461681458 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363533 Nc1nn2c(N)c(C#N)c(nc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(Br)cc1 InChI=1S/C19H14BrN9O2S/c20-11-3-1-10(2-4-11)15-14(9-21)18(23)29-19(25-15)16(17(22)28-29)27-26-12-5-7-13(8-6-12)32(24,30)31/h1-8H,23H2,(H2,22,28)(H2,24,30,31)/b27-26+ GOYOUJUULDCBIC-CYYJNZCTSA-N 50551119 CHEMBL4782119 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551119&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162395480 461681459 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363534 Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)/b13-12+ AYZRKFOEZQBUEA-OUKQBFOZSA-N 50455463 CHEMBL215205 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455463&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 135398514 433923556 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51363535 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1800 ChEMBL 10.1016/j.ejmech.2019.112019 10.7270/Q2Z3238X 31972394 Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Kryštof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358871 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 711 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358872 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(F)cn1 InChI=1S/C22H28FN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 JTIFUJUJDWUQEV-LSDHHAIUSA-N 454542 US10717746, Example 25::US10717746, Example 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 569 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155169 440970408 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358873 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCc23)c(Cl)cn1 InChI=1S/C21H26ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-20-10-16(18(22)12-23-20)17-11-24-27-8-3-2-7-19(17)27/h10-12,14-15H,2-9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 AKIBGBJFUGFCIJ-LSDHHAIUSA-N 454519 US10717746, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3640 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155310 440970385 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358874 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.089400 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358875 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(F)cn1 InChI=1S/C22H28FN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 JTIFUJUJDWUQEV-LSDHHAIUSA-N 454542 US10717746, Example 25::US10717746, Example 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.123000 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155169 440970408 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358876 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCc23)c(Cl)cn1 InChI=1S/C21H26ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-20-10-16(18(22)12-23-20)17-11-24-27-8-3-2-7-19(17)27/h10-12,14-15H,2-9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 AKIBGBJFUGFCIJ-LSDHHAIUSA-N 454519 US10717746, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.295000 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155310 440970385 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358906 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cn[nH]c2CC(C)(C)CO)c(Cl)cn1 454598 US10717746, Example 82a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 139 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155180 440970462 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358907 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3C(O)C(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O3/c1-12(29)26-14-6-4-5-13(7-14)20(30)27-19-8-15(17(23)11-24-19)16-10-25-28-18(16)9-22(2,3)21(28)31/h8,10-11,13-14,21,31H,4-7,9H2,1-3H3,(H,26,29)(H,24,27,30)/t13-,14+,21?/m0/s1 SLBMMPZICNYISW-MOUIRZPISA-N 454597 US10717746, Example 82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155185 440970461 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358908 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cn[nH]c2CCCCO)c(Cl)cn1 454594 US10717746, Example 78a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454594&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155243 440970458 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358909 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3C(O)CCCc23)c(Cl)cn1 InChI=1S/C21H26ClN5O3/c1-12(28)25-14-5-2-4-13(8-14)21(30)26-19-9-15(17(22)11-23-19)16-10-24-27-18(16)6-3-7-20(27)29/h9-11,13-14,20,29H,2-8H2,1H3,(H,25,28)(H,23,26,30)/t13-,14+,20?/m0/s1 BRQSWVAJJNFGEP-IODPJOFQSA-N 454593 US10717746, Example 78 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454593&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155270 440970457 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358910 CC1(C)Cc2c(cnn2C1)-c1cc(NC(=O)[C@@H]2C[C@H](O)C2)ncc1Cl InChI=1S/C18H21ClN4O2/c1-18(2)6-15-13(7-21-23(15)9-18)12-5-16(20-8-14(12)19)22-17(25)10-3-11(24)4-10/h5,7-8,10-11,24H,3-4,6,9H2,1-2H3,(H,20,22,25)/t10-,11+ BJVQHPTYDFVVJV-PHIMTYICSA-N 454544 US10717746, Example 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454544&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155226 440970410 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358911 CC(=O)N[C@@H]1CC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C21H26ClN5O2/c1-12(28)25-14-5-4-13(6-14)20(29)26-19-7-15(17(22)10-23-19)16-9-24-27-11-21(2,3)8-18(16)27/h7,9-10,13-14H,4-6,8,11H2,1-3H3,(H,25,28)(H,23,26,29)/t13-,14+/m0/s1 XXPDEKKKGHCODA-UONOGXRCSA-N 454567 US10717746, Example 48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454567&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155338 440970431 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358912 CC(=O)NC1CCCC(C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30) AVIWDYSJSPOOAR-UHFFFAOYSA-N 50549515 CHEMBL4759074 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155206 461679855 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358913 CC(=O)NC1CCCC(C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30) AVIWDYSJSPOOAR-UHFFFAOYSA-N 50549515 CHEMBL4759074 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6800 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155206 461679855 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358914 CC(=O)N[C@H]1CCC[C@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m1/s1 AVIWDYSJSPOOAR-CABCVRRESA-N 454562 US10717746, Example 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 290 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155198 440970426 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358915 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnc3CC(C)(C)Cn23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-19-8-16(17(23)10-24-19)18-11-25-20-9-22(2,3)12-28(18)20/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AKHNSDCQWFJNJI-LSDHHAIUSA-N 454539 US10717746, Example 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454539&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155389 440970405 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358916 CC1Cc2c(cnn2C1)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C21H26ClN5O2/c1-12-6-19-17(9-24-27(19)11-12)16-8-20(23-10-18(16)22)26-21(29)14-4-3-5-15(7-14)25-13(2)28/h8-10,12,14-15H,3-7,11H2,1-2H3,(H,25,28)(H,23,26,29)/t12?,14-,15+/m0/s1 KZJSUGHOGMRTFQ-JQXSQYPDSA-N 454559 US10717746, Example 40::US10717746, Example 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155320 440970424 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358917 CC1Cc2c(cnn2C1)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C21H26ClN5O2/c1-12-6-19-17(9-24-27(19)11-12)16-8-20(23-10-18(16)22)26-21(29)14-4-3-5-15(7-14)25-13(2)28/h8-10,12,14-15H,3-7,11H2,1-2H3,(H,25,28)(H,23,26,29)/t12?,14-,15+/m0/s1 KZJSUGHOGMRTFQ-JQXSQYPDSA-N 454559 US10717746, Example 40::US10717746, Example 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155320 440970424 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358918 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(C)cn1 InChI=1S/C23H31N5O2/c1-14-11-24-21(27-22(30)16-6-5-7-17(8-16)26-15(2)29)9-18(14)19-12-25-28-13-23(3,4)10-20(19)28/h9,11-12,16-17H,5-8,10,13H2,1-4H3,(H,26,29)(H,24,27,30)/t16-,17+/m0/s1 NDQRCUOYOAPFLR-DLBZAZTESA-N 454566 US10717746, Example 47 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454566&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155258 440970430 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358919 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(cn1)C#N InChI=1S/C23H28N6O2/c1-14(30)27-17-6-4-5-15(7-17)22(31)28-21-8-18(16(10-24)11-25-21)19-12-26-29-13-23(2,3)9-20(19)29/h8,11-12,15,17H,4-7,9,13H2,1-3H3,(H,27,30)(H,25,28,31)/t15-,17+/m0/s1 WCCDPNHGMPXBNQ-DOTOQJQBSA-N 454558 US10717746, Example 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155190 440970423 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358920 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <4.0 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358921 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(F)cn1 InChI=1S/C22H28FN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 JTIFUJUJDWUQEV-LSDHHAIUSA-N 454542 US10717746, Example 25::US10717746, Example 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155169 440970408 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358922 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(ccn1)-c1cnn2CC(C)(C)Cc12 InChI=1S/C22H29N5O2/c1-14(28)25-17-6-4-5-16(9-17)21(29)26-20-10-15(7-8-23-20)18-12-24-27-13-22(2,3)11-19(18)27/h7-8,10,12,16-17H,4-6,9,11,13H2,1-3H3,(H,25,28)(H,23,26,29)/t16-,17+/m0/s1 SFJPXLFAVIITJQ-DLBZAZTESA-N 454533 US10717746, Example 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155401 440970399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358923 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCC(C)(C)Cc23)c(F)cn1 InChI=1S/C23H30FN5O2/c1-14(30)27-16-6-4-5-15(9-16)22(31)28-21-10-17(19(24)13-25-21)18-12-26-29-8-7-23(2,3)11-20(18)29/h10,12-13,15-16H,4-9,11H2,1-3H3,(H,27,30)(H,25,28,31)/t15-,16+/m0/s1 ZNUJHRYFOFHSMX-JKSUJKDBSA-N 454570 US10717746, Example 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <3.0 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155311 440970434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358924 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(ccn1)-c1cnn2CCC(C)(C)Cc12 InChI=1S/C23H31N5O2/c1-15(29)26-18-6-4-5-17(11-18)22(30)27-21-12-16(7-9-24-21)19-14-25-28-10-8-23(2,3)13-20(19)28/h7,9,12,14,17-18H,4-6,8,10-11,13H2,1-3H3,(H,26,29)(H,24,27,30)/t17-,18+/m0/s1 VNWYGUWLGRESFH-ZWKOTPCHSA-N 454563 US10717746, Example 44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454563&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155215 440970427 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358925 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCOc23)c(Cl)cn1 InChI=1S/C20H24ClN5O3/c1-12(27)24-14-5-2-4-13(8-14)19(28)25-18-9-15(17(21)11-22-18)16-10-23-26-6-3-7-29-20(16)26/h9-11,13-14H,2-8H2,1H3,(H,24,27)(H,22,25,28)/t13-,14+/m0/s1 IIFJRNNBNQWDLA-UONOGXRCSA-N 454525 US10717746, Example 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 110 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454525&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155184 440970391 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358926 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCNc23)c(Cl)cn1 InChI=1S/C20H25ClN6O2/c1-12(28)25-14-5-2-4-13(8-14)20(29)26-18-9-15(17(21)11-23-18)16-10-24-27-7-3-6-22-19(16)27/h9-11,13-14,22H,2-8H2,1H3,(H,25,28)(H,23,26,29)/t13-,14+/m0/s1 HGTYXDXGMWEQPT-UONOGXRCSA-N 454532 US10717746, Example 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 350 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 137131949 440970398 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358927 CN1CCn2ncc(c2C1)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C21H27ClN6O2/c1-13(29)25-15-5-3-4-14(8-15)21(30)26-20-9-16(18(22)11-23-20)17-10-24-28-7-6-27(2)12-19(17)28/h9-11,14-15H,3-8,12H2,1-2H3,(H,25,29)(H,23,26,30)/t14-,15+/m0/s1 CFOMPAUTQPTGQD-LSDHHAIUSA-N 454530 US10717746, Example 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 220 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454530&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155216 440970396 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358928 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCOCc23)c(Cl)cn1 InChI=1S/C20H24ClN5O3/c1-12(27)24-14-4-2-3-13(7-14)20(28)25-19-8-15(17(21)10-22-19)16-9-23-26-5-6-29-11-18(16)26/h8-10,13-14H,2-7,11H2,1H3,(H,24,27)(H,22,25,28)/t13-,14+/m0/s1 CUVDIVXPUWFCOD-UONOGXRCSA-N 454528 US10717746, Example 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454528&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155203 440970394 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358929 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCCc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-14(29)26-16-7-5-6-15(10-16)22(30)27-21-11-17(19(23)13-24-21)18-12-25-28-9-4-2-3-8-20(18)28/h11-13,15-16H,2-10H2,1H3,(H,26,29)(H,24,27,30)/t15-,16+/m0/s1 NEIZYLBJBXFABU-JKSUJKDBSA-N 454584 US10717746, Example 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155280 440970448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358930 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnc3CCCn23)c(Cl)cn1 InChI=1S/C20H24ClN5O2/c1-12(27)24-14-5-2-4-13(8-14)20(28)25-18-9-15(16(21)10-22-18)17-11-23-19-6-3-7-26(17)19/h9-11,13-14H,2-8H2,1H3,(H,24,27)(H,22,25,28)/t13-,14+/m0/s1 OHJQYFCYYWSDGL-UONOGXRCSA-N 454529 US10717746, Example 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 310 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454529&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155397 440970395 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358931 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCc23)c(Cl)cn1 InChI=1S/C20H24ClN5O2/c1-12(27)24-14-5-2-4-13(8-14)20(28)25-19-9-15(17(21)11-22-19)16-10-23-26-7-3-6-18(16)26/h9-11,13-14H,2-8H2,1H3,(H,24,27)(H,22,25,28)/t13-,14+/m0/s1 YFAKZUMJVBULBO-UONOGXRCSA-N 454527 US10717746, Example 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155248 440970393 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358932 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2nnn3ccccc23)c(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-12(28)23-14-6-4-5-13(9-14)20(29)24-18-10-15(16(21)11-22-18)19-17-7-2-3-8-27(17)26-25-19/h2-3,7-8,10-11,13-14H,4-6,9H2,1H3,(H,23,28)(H,22,24,29)/t13-,14+/m0/s1 KEMVWIFBROQSEE-UONOGXRCSA-N 50549516 CHEMBL4764938 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4400 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549516&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162662309 461679856 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358933 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnc3ccccn23)c(Cl)cn1 InChI=1S/C21H22ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-19-10-16(17(22)11-23-19)18-12-24-20-7-2-3-8-27(18)20/h2-3,7-8,10-12,14-15H,4-6,9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 PRFNXJNNHKTTHP-LSDHHAIUSA-N 50549517 CHEMBL4765079 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 750 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549517&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162662129 461679857 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358934 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnc(C)n2C)c(Cl)cn1 InChI=1S/C19H24ClN5O2/c1-11-21-10-17(25(11)3)15-8-18(22-9-16(15)20)24-19(27)13-5-4-6-14(7-13)23-12(2)26/h8-10,13-14H,4-7H2,1-3H3,(H,23,26)(H,22,24,27)/t13-,14+/m0/s1 XSIKCQKRTDNUSY-UONOGXRCSA-N 50549518 CHEMBL4799201 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5300 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162677319 461679858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358935 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnc3CCCCn23)c(Cl)cn1 InChI=1S/C21H26ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-19-10-16(17(22)11-23-19)18-12-24-20-7-2-3-8-27(18)20/h10-12,14-15H,2-9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 XPZMRZUXNMEPOS-LSDHHAIUSA-N 454524 US10717746, Example 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 660 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454524&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155359 440970390 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358936 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3ccccc23)c(Cl)cn1 InChI=1S/C21H22ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-20-10-16(18(22)12-23-20)17-11-24-27-8-3-2-7-19(17)27/h2-3,7-8,10-12,14-15H,4-6,9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 GHLVLJWBRRRDIH-LSDHHAIUSA-N 50549519 CHEMBL4759053 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 61 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162658684 461679859 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358937 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn(C)c2C)c(Cl)cn1 InChI=1S/C19H24ClN5O2/c1-11-16(9-22-25(11)3)15-8-18(21-10-17(15)20)24-19(27)13-5-4-6-14(7-13)23-12(2)26/h8-10,13-14H,4-7H2,1-3H3,(H,23,26)(H,21,24,27)/t13-,14+/m0/s1 JLFRFPIPIGBBMO-UONOGXRCSA-N 50549520 CHEMBL4758821 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 270 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162657446 461679860 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358938 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCc23)c(Cl)cn1 InChI=1S/C21H26ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-20-10-16(18(22)12-23-20)17-11-24-27-8-3-2-7-19(17)27/h10-12,14-15H,2-9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 AKIBGBJFUGFCIJ-LSDHHAIUSA-N 454519 US10717746, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155310 440970385 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358939 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCc23)c(F)cn1 InChI=1S/C21H26FN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-20-10-16(18(22)12-23-20)17-11-24-27-8-3-2-7-19(17)27/h10-12,14-15H,2-9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 UKQNWDWADMKKFN-LSDHHAIUSA-N 454582 US10717746, Example 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155244 440970446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358940 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(ccn1)-c1cnn2CCCCc12 InChI=1S/C21H27N5O2/c1-14(27)24-17-6-4-5-16(11-17)21(28)25-20-12-15(8-9-22-20)18-13-23-26-10-3-2-7-19(18)26/h8-9,12-13,16-17H,2-7,10-11H2,1H3,(H,24,27)(H,22,25,28)/t16-,17+/m0/s1 ASEPZBUAEOJUCM-DLBZAZTESA-N 454520 US10717746, Example 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 124155402 440970386 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358941 CC(C)n1c(C)ncc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 InChI=1S/C21H29N5O2/c1-13(2)26-14(3)23-12-19(26)16-8-9-22-20(11-16)25-21(28)17-6-5-7-18(10-17)24-15(4)27/h8-9,11-13,17-18H,5-7,10H2,1-4H3,(H,24,27)(H,22,25,28)/t17-,18+/m0/s1 HDSTXIMWVAEDEM-ZWKOTPCHSA-N 50549521 CHEMBL4760601 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 380 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162658218 461679861 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51358942 COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 InChI=1S/C21H24FN3O3/c1-13(26)24-17-5-3-4-15(10-17)21(27)25-20-11-14(8-9-23-20)18-7-6-16(22)12-19(18)28-2/h6-9,11-12,15,17H,3-5,10H2,1-2H3,(H,24,26)(H,23,25,27)/t15-,17+/m0/s1 QNWXRLPZIFMTBK-DOTOQJQBSA-N 164883 US9067888, 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164883&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 53373586 311419854 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397819 CN1CCC(=CC1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(Sc2nc3ccccc3[nH]2)cc1 InChI=1S/C28H23N3O4S/c1-31-12-10-17(11-13-31)25-21(32)14-22(33)26-23(34)15-24(35-27(25)26)16-6-8-18(9-7-16)36-28-29-19-4-2-3-5-20(19)30-28/h2-10,14-15,32-33H,11-13H2,1H3,(H,29,30) NBOBLXOZHBALAX-UHFFFAOYSA-N 50564716 CHEMBL4790926 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2020.112355 10.7270/Q28P649Z 32402934 Ibrahim, N; Bonnet, P; Brion, JD; Peyrat, JF; Bignon, J; Levaique, H; Josselin, B; Robert, T; Colas, P; Bach, S; Messaoudi, S; Alami, M; Hamze, A University Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564716&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162670378 461685054 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397820 CN1CCC(=CC1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(Sc2nc(c[nH]2)-c2ccccc2)cc1 InChI=1S/C30H25N3O4S/c1-33-13-11-20(12-14-33)27-23(34)15-24(35)28-25(36)16-26(37-29(27)28)19-7-9-21(10-8-19)38-30-31-17-22(32-30)18-5-3-2-4-6-18/h2-11,15-17,34-35H,12-14H2,1H3,(H,31,32) FRCIRPZMZDFVMQ-UHFFFAOYSA-N 50564717 CHEMBL4787876 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.ejmech.2020.112355 10.7270/Q28P649Z 32402934 Ibrahim, N; Bonnet, P; Brion, JD; Peyrat, JF; Bignon, J; Levaique, H; Josselin, B; Robert, T; Colas, P; Bach, S; Messaoudi, S; Alami, M; Hamze, A University Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564717&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162668485 461685055 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397821 CN1CCC(=CC1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(Sc2nc3ccccc3n2C)cc1 InChI=1S/C29H25N3O4S/c1-31-13-11-18(12-14-31)26-22(33)15-23(34)27-24(35)16-25(36-28(26)27)17-7-9-19(10-8-17)37-29-30-20-5-3-4-6-21(20)32(29)2/h3-11,15-16,33-34H,12-14H2,1-2H3 JPLLQSBSTHWUIK-UHFFFAOYSA-N 50564718 CHEMBL4781618 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2020.112355 10.7270/Q28P649Z 32402934 Ibrahim, N; Bonnet, P; Brion, JD; Peyrat, JF; Bignon, J; Levaique, H; Josselin, B; Robert, T; Colas, P; Bach, S; Messaoudi, S; Alami, M; Hamze, A University Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564718&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162664818 461685056 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397822 CN1CCC(=CC1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(Sc2nc3ccccc3[nH]2)cc1Cl InChI=1S/C28H22ClN3O4S/c1-32-10-8-15(9-11-32)25-21(33)13-22(34)26-23(35)14-24(36-27(25)26)17-7-6-16(12-18(17)29)37-28-30-19-4-2-3-5-20(19)31-28/h2-8,12-14,33-34H,9-11H2,1H3,(H,30,31) GSRHVOVIIWBRTN-UHFFFAOYSA-N 50564719 CHEMBL4793858 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2020.112355 10.7270/Q28P649Z 32402934 Ibrahim, N; Bonnet, P; Brion, JD; Peyrat, JF; Bignon, J; Levaique, H; Josselin, B; Robert, T; Colas, P; Bach, S; Messaoudi, S; Alami, M; Hamze, A University Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564719&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162673278 461685057 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397823 CN1CCC(=CC1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(Sc2nc3ccccc3n2C)cc1Cl InChI=1S/C29H24ClN3O4S/c1-32-11-9-16(10-12-32)26-22(34)14-23(35)27-24(36)15-25(37-28(26)27)18-8-7-17(13-19(18)30)38-29-31-20-5-3-4-6-21(20)33(29)2/h3-9,13-15,34-35H,10-12H2,1-2H3 BTDCUFCJAWQJCI-UHFFFAOYSA-N 50564720 CHEMBL4788045 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64 ChEMBL 10.1016/j.ejmech.2020.112355 10.7270/Q28P649Z 32402934 Ibrahim, N; Bonnet, P; Brion, JD; Peyrat, JF; Bignon, J; Levaique, H; Josselin, B; Robert, T; Colas, P; Bach, S; Messaoudi, S; Alami, M; Hamze, A University Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564720&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162668727 461685058 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397824 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2020.112355 10.7270/Q28P649Z 32402934 Ibrahim, N; Bonnet, P; Brion, JD; Peyrat, JF; Bignon, J; Levaique, H; Josselin, B; Robert, T; Colas, P; Bach, S; Messaoudi, S; Alami, M; Hamze, A University Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51396913 CC(C)c1cn2c(n1)c(C(C)=O)c(C)c1cnc(Nc3ccc(cc3)N3CCNCC3)nc21 InChI=1S/C25H29N7O/c1-15(2)21-14-32-23-20(16(3)22(17(4)33)24(32)29-21)13-27-25(30-23)28-18-5-7-19(8-6-18)31-11-9-26-10-12-31/h5-8,13-15,26H,9-12H2,1-4H3,(H,27,28,30) DEVYXOKAXWLJRC-UHFFFAOYSA-N 50564275 CHEMBL4778367 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564275&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156024485 461684613 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51396914 CC(=O)c1c(C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc2n2cc(nc12)C(C)(C)C InChI=1S/C26H31N7O/c1-16-20-14-28-25(29-18-6-8-19(9-7-18)32-12-10-27-11-13-32)31-23(20)33-15-21(26(3,4)5)30-24(33)22(16)17(2)34/h6-9,14-15,27H,10-13H2,1-5H3,(H,28,29,31) QCXLRAYMDUWMRT-UHFFFAOYSA-N 50564276 CHEMBL4776781 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 221 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564276&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162643767 461684614 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51396915 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1917 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51396916 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397956 CC(=O)c1c(C)c2ccc(Nc3nccc(n3)-c3cccnc3)cc2oc1=O InChI=1S/C21H16N4O3/c1-12-16-6-5-15(10-18(16)28-20(27)19(12)13(2)26)24-21-23-9-7-17(25-21)14-4-3-8-22-11-14/h3-11H,1-2H3,(H,23,24,25) QNFBTXLSIOCFSM-UHFFFAOYSA-N 50564790 CHEMBL4781627 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 184 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564790&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677550 461685128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397957 COc1ccccc1-c1ccnc(Nc2ccc3c(C)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C23H19N3O4/c1-13-16-9-8-15(12-20(16)30-22(28)21(13)14(2)27)25-23-24-11-10-18(26-23)17-6-4-5-7-19(17)29-3/h4-12H,1-3H3,(H,24,25,26) IVEUUAYDXCENND-UHFFFAOYSA-N 50564791 CHEMBL4799242 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.5 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564791&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677652 461685129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397958 COc1ccccc1-c1cc(Nc2ccc3c(C)c(C(C)=O)c(=O)oc3c2)ncn1 InChI=1S/C23H19N3O4/c1-13-16-9-8-15(10-20(16)30-23(28)22(13)14(2)27)26-21-11-18(24-12-25-21)17-6-4-5-7-19(17)29-3/h4-12H,1-3H3,(H,24,25,26) BPVRBKCKGLCMHX-UHFFFAOYSA-N 50564792 CHEMBL4777022 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564792&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677583 461685130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397959 COc1ccccc1-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C26H24N4O5/c1-16(31)23-24(30-11-13-34-14-12-30)19-8-7-17(15-22(19)35-25(23)32)28-26-27-10-9-20(29-26)18-5-3-4-6-21(18)33-2/h3-10,15H,11-14H2,1-2H3,(H,27,28,29) SWQLIIAAXLKOKM-UHFFFAOYSA-N 50564793 CHEMBL4797583 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.1 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564793&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677666 461685131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397960 CCc1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccccc3OC)cc2oc1=O InChI=1S/C26H26N4O4/c1-3-18-24(30-12-14-33-15-13-30)20-9-8-17(16-23(20)34-25(18)31)28-26-27-11-10-21(29-26)19-6-4-5-7-22(19)32-2/h4-11,16H,3,12-15H2,1-2H3,(H,27,28,29) OEYCBKIODFYBLX-UHFFFAOYSA-N 50564794 CHEMBL4799477 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564794&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677558 461685132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397961 COc1ccccc1-c1ccnc(Nc2ccc3c(cc(=O)oc3c2)N2CCOCC2)n1 InChI=1S/C24H22N4O4/c1-30-21-5-3-2-4-17(21)19-8-9-25-24(27-19)26-16-6-7-18-20(28-10-12-31-13-11-28)15-23(29)32-22(18)14-16/h2-9,14-15H,10-13H2,1H3,(H,25,26,27) DEPDCFOGWJYNAD-UHFFFAOYSA-N 50564795 CHEMBL4784367 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564795&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677608 461685133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397962 COc1ccccc1-c1ccnc(Nc2ccc3c(cc(=O)oc3c2)N2CCNCC2)n1 InChI=1S/C24H23N5O3/c1-31-21-5-3-2-4-17(21)19-8-9-26-24(28-19)27-16-6-7-18-20(29-12-10-25-11-13-29)15-23(30)32-22(18)14-16/h2-9,14-15,25H,10-13H2,1H3,(H,26,27,28) WTYJTOIPHWBWPT-UHFFFAOYSA-N 50564796 CHEMBL4781709 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564796&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677673 461685134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397963 COc1ccccc1-c1ccnc(Nc2ccc3c(cc(=O)oc3c2)N2CCCNCC2)n1 InChI=1S/C25H25N5O3/c1-32-22-6-3-2-5-18(22)20-9-11-27-25(29-20)28-17-7-8-19-21(16-24(31)33-23(19)15-17)30-13-4-10-26-12-14-30/h2-3,5-9,11,15-16,26H,4,10,12-14H2,1H3,(H,27,28,29) DSJXCHFPWCIVHH-UHFFFAOYSA-N 50564797 CHEMBL4794868 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564797&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162673327 461685135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397964 COc1cccc(c1)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C26H24N4O5/c1-16(31)23-24(30-10-12-34-13-11-30)20-7-6-18(15-22(20)35-25(23)32)28-26-27-9-8-21(29-26)17-4-3-5-19(14-17)33-2/h3-9,14-15H,10-13H2,1-2H3,(H,27,28,29) KBVZMRABFVBGQW-UHFFFAOYSA-N 50564798 CHEMBL4781267 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564798&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677589 461685136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397965 COc1ccc(cc1)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C26H24N4O5/c1-16(31)23-24(30-11-13-34-14-12-30)20-8-5-18(15-22(20)35-25(23)32)28-26-27-10-9-21(29-26)17-3-6-19(33-2)7-4-17/h3-10,15H,11-14H2,1-2H3,(H,27,28,29) LZGPQLHYALQVDQ-UHFFFAOYSA-N 50564799 CHEMBL4789815 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564799&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677650 461685137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397966 COc1ccc(c(OC)c1)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C27H26N4O6/c1-16(32)24-25(31-10-12-36-13-11-31)20-6-4-17(14-23(20)37-26(24)33)29-27-28-9-8-21(30-27)19-7-5-18(34-2)15-22(19)35-3/h4-9,14-15H,10-13H2,1-3H3,(H,28,29,30) CPLQNKPEJZQESV-UHFFFAOYSA-N 50564800 CHEMBL4776793 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 54 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564800&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677598 461685138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397967 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccccc3)cc2oc1=O InChI=1S/C25H22N4O4/c1-16(30)22-23(29-11-13-32-14-12-29)19-8-7-18(15-21(19)33-24(22)31)27-25-26-10-9-20(28-25)17-5-3-2-4-6-17/h2-10,15H,11-14H2,1H3,(H,26,27,28) APRLEKXLWNOBKU-UHFFFAOYSA-N 50564801 CHEMBL4791056 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 228 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564801&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677564 461685139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397968 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3c(F)cccc3F)cc2oc1=O InChI=1S/C25H20F2N4O4/c1-14(32)21-23(31-9-11-34-12-10-31)16-6-5-15(13-20(16)35-24(21)33)29-25-28-8-7-19(30-25)22-17(26)3-2-4-18(22)27/h2-8,13H,9-12H2,1H3,(H,28,29,30) GUNJVVRBBQEUJG-UHFFFAOYSA-N 50564802 CHEMBL4797760 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 267 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564802&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677597 461685140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397969 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccccc3C(F)(F)F)cc2oc1=O InChI=1S/C26H21F3N4O4/c1-15(34)22-23(33-10-12-36-13-11-33)18-7-6-16(14-21(18)37-24(22)35)31-25-30-9-8-20(32-25)17-4-2-3-5-19(17)26(27,28)29/h2-9,14H,10-13H2,1H3,(H,30,31,32) ZDFBYYMGZCQFNB-UHFFFAOYSA-N 50564803 CHEMBL4790590 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2488 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564803&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677548 461685141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397970 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccccc3[N+]([O-])=O)cc2oc1=O InChI=1S/C25H21N5O6/c1-15(31)22-23(29-10-12-35-13-11-29)18-7-6-16(14-21(18)36-24(22)32)27-25-26-9-8-19(28-25)17-4-2-3-5-20(17)30(33)34/h2-9,14H,10-13H2,1H3,(H,26,27,28) RVGBAWZNWQFUGI-UHFFFAOYSA-N 50564804 CHEMBL4777619 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2335 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564804&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677664 461685142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397971 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccccc3C)cc2oc1=O InChI=1S/C26H24N4O4/c1-16-5-3-4-6-19(16)21-9-10-27-26(29-21)28-18-7-8-20-22(15-18)34-25(32)23(17(2)31)24(20)30-11-13-33-14-12-30/h3-10,15H,11-14H2,1-2H3,(H,27,28,29) BHISNYJXWAVZHJ-UHFFFAOYSA-N 50564805 CHEMBL4800337 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 489 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564805&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677638 461685143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397972 CCc1ccccc1-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C27H26N4O4/c1-3-18-6-4-5-7-20(18)22-10-11-28-27(30-22)29-19-8-9-21-23(16-19)35-26(33)24(17(2)32)25(21)31-12-14-34-15-13-31/h4-11,16H,3,12-15H2,1-2H3,(H,28,29,30) IANVLDASVRSUQO-UHFFFAOYSA-N 50564806 CHEMBL4793330 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 67 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564806&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677569 461685144 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397973 COc1ccccc1-c1cc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)ncn1 InChI=1S/C26H24N4O5/c1-16(31)24-25(30-9-11-34-12-10-30)19-8-7-17(13-22(19)35-26(24)32)29-23-14-20(27-15-28-23)18-5-3-4-6-21(18)33-2/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29) XERAIFKMKCSFBR-UHFFFAOYSA-N 50564807 CHEMBL4793126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564807&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677672 461685145 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397974 COc1cc(F)ccc1-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C26H23FN4O5/c1-15(32)23-24(31-9-11-35-12-10-31)19-6-4-17(14-22(19)36-25(23)33)29-26-28-8-7-20(30-26)18-5-3-16(27)13-21(18)34-2/h3-8,13-14H,9-12H2,1-2H3,(H,28,29,30) FTGMCTBSWOHGKU-UHFFFAOYSA-N 50564808 CHEMBL4794955 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.8 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564808&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677671 461685146 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397975 COc1ccc(F)cc1-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C26H23FN4O5/c1-15(32)23-24(31-9-11-35-12-10-31)18-5-4-17(14-22(18)36-25(23)33)29-26-28-8-7-20(30-26)19-13-16(27)3-6-21(19)34-2/h3-8,13-14H,9-12H2,1-2H3,(H,28,29,30) JAGSBTCNHPBZIM-UHFFFAOYSA-N 50564809 CHEMBL4792494 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564809&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677577 461685147 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397976 COc1cccc(F)c1-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C26H23FN4O5/c1-15(32)22-24(31-10-12-35-13-11-31)17-7-6-16(14-21(17)36-25(22)33)29-26-28-9-8-19(30-26)23-18(27)4-3-5-20(23)34-2/h3-9,14H,10-13H2,1-2H3,(H,28,29,30) RXLKGKJSOZFSEN-UHFFFAOYSA-N 50564810 CHEMBL4778633 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564810&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677575 461685148 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397977 COc1cc(F)ccc1-c1ccnc(Nc2ccc3c(N4CCN(C)CC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C27H26FN5O4/c1-16(34)24-25(33-12-10-32(2)11-13-33)20-7-5-18(15-23(20)37-26(24)35)30-27-29-9-8-21(31-27)19-6-4-17(28)14-22(19)36-3/h4-9,14-15H,10-13H2,1-3H3,(H,29,30,31) XZKBHFRAGXAXSC-UHFFFAOYSA-N 50564811 CHEMBL4778363 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564811&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677579 461685149 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397978 CCN1CCN(CC1)c1c(C(C)=O)c(=O)oc2cc(Nc3nccc(n3)-c3ccc(F)cc3OC)ccc12 InChI=1S/C28H28FN5O4/c1-4-33-11-13-34(14-12-33)26-21-8-6-19(16-24(21)38-27(36)25(26)17(2)35)31-28-30-10-9-22(32-28)20-7-5-18(29)15-23(20)37-3/h5-10,15-16H,4,11-14H2,1-3H3,(H,30,31,32) GBLAKTIMBSDZRA-UHFFFAOYSA-N 50564812 CHEMBL4788106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564812&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677601 461685150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397979 COc1cc(F)ccc1-c1ccnc(Nc2ccc3c(N4CCCCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C27H25FN4O4/c1-16(33)24-25(32-12-4-3-5-13-32)20-9-7-18(15-23(20)36-26(24)34)30-27-29-11-10-21(31-27)19-8-6-17(28)14-22(19)35-2/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,29,30,31) XLEXQTAZFDJBEA-UHFFFAOYSA-N 50564813 CHEMBL4789969 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.5 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564813&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677613 461685151 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397980 CCC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc(F)cc3OC)cc2oc1=O InChI=1S/C27H25FN4O5/c1-3-21(33)24-25(32-10-12-36-13-11-32)19-7-5-17(15-23(19)37-26(24)34)30-27-29-9-8-20(31-27)18-6-4-16(28)14-22(18)35-2/h4-9,14-15H,3,10-13H2,1-2H3,(H,29,30,31) FDDRHWAVGSBKFR-UHFFFAOYSA-N 50564814 CHEMBL4779517 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.6 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564814&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677630 461685152 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397981 COc1cc(F)ccc1-c1ccnc(Nc2ccc3c(cc(=O)oc3c2)N2CCOCC2)n1 InChI=1S/C24H21FN4O4/c1-31-21-12-15(25)2-4-17(21)19-6-7-26-24(28-19)27-16-3-5-18-20(29-8-10-32-11-9-29)14-23(30)33-22(18)13-16/h2-7,12-14H,8-11H2,1H3,(H,26,27,28) MDVMDFSKPQUJPQ-UHFFFAOYSA-N 50564815 CHEMBL4779055 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564815&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677585 461685153 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397982 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)ncc1F InChI=1S/C26H22F2N4O5/c1-14(33)22-24(32-7-9-36-10-8-32)18-6-4-16(12-21(18)37-25(22)34)30-26-29-13-19(28)23(31-26)17-5-3-15(27)11-20(17)35-2/h3-6,11-13H,7-10H2,1-2H3,(H,29,30,31) RDOKVGWGKMHBMG-UHFFFAOYSA-N 50564816 CHEMBL4788347 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564816&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677629 461685154 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397983 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCN(C)CC4)c(C(C)=O)c(=O)oc3c2)ncc1F InChI=1S/C27H25F2N5O4/c1-15(35)23-25(34-10-8-33(2)9-11-34)19-7-5-17(13-22(19)38-26(23)36)31-27-30-14-20(29)24(32-27)18-6-4-16(28)12-21(18)37-3/h4-7,12-14H,8-11H2,1-3H3,(H,30,31,32) LHXPKQBNRWZDLD-UHFFFAOYSA-N 50564817 CHEMBL4785869 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.5 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162668085 461685155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397984 CCN1CCN(CC1)c1c(C(C)=O)c(=O)oc2cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)ccc12 InChI=1S/C28H27F2N5O4/c1-4-34-9-11-35(12-10-34)26-20-8-6-18(14-23(20)39-27(37)24(26)16(2)36)32-28-31-15-21(30)25(33-28)19-7-5-17(29)13-22(19)38-3/h5-8,13-15H,4,9-12H2,1-3H3,(H,31,32,33) FENPXPBUKNHHHM-UHFFFAOYSA-N 50564818 CHEMBL4779614 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564818&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162662953 461685156 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397985 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCCNCC4)c(C(C)=O)c(=O)oc3c2)ncc1F InChI=1S/C27H25F2N5O4/c1-15(35)23-25(34-10-3-8-30-9-11-34)19-7-5-17(13-22(19)38-26(23)36)32-27-31-14-20(29)24(33-27)18-6-4-16(28)12-21(18)37-2/h4-7,12-14,30H,3,8-11H2,1-2H3,(H,31,32,33) HOARYCLJOWBNCE-UHFFFAOYSA-N 50564819 CHEMBL4786572 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564819&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162668356 461685157 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397986 CCC(=O)c1c(N2CCOCC2)c2ccc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc2oc1=O InChI=1S/C27H24F2N4O5/c1-3-20(34)23-25(33-8-10-37-11-9-33)18-7-5-16(13-22(18)38-26(23)35)31-27-30-14-19(29)24(32-27)17-6-4-15(28)12-21(17)36-2/h4-7,12-14H,3,8-11H2,1-2H3,(H,30,31,32) HDSMDAXOECRDBG-UHFFFAOYSA-N 50564820 CHEMBL4785212 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.700000 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564820&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162666482 461685158 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397987 COc1cc(F)ccc1-c1nc(Nc2ccc3c(cc(=O)oc3c2)N2CCOCC2)ncc1F InChI=1S/C24H20F2N4O4/c1-32-20-10-14(25)2-4-17(20)23-18(26)13-27-24(29-23)28-15-3-5-16-19(30-6-8-33-9-7-30)12-22(31)34-21(16)11-15/h2-5,10-13H,6-9H2,1H3,(H,27,28,29) JSHQBITYFQKJER-UHFFFAOYSA-N 50564821 CHEMBL4782957 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564821&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162665150 461685159 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397988 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)ncc1Cl InChI=1S/C26H22ClFN4O5/c1-14(33)22-24(32-7-9-36-10-8-32)18-6-4-16(12-21(18)37-25(22)34)30-26-29-13-19(27)23(31-26)17-5-3-15(28)11-20(17)35-2/h3-6,11-13H,7-10H2,1-2H3,(H,29,30,31) CLHZKZYRISNUNI-UHFFFAOYSA-N 50564822 CHEMBL4796766 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.6 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564822&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677612 461685160 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51397989 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCN(C)CC4)c(C(C)=O)c(=O)oc3c2)ncc1Cl InChI=1S/C27H25ClFN5O4/c1-15(35)23-25(34-10-8-33(2)9-11-34)19-7-5-17(13-22(19)38-26(23)36)31-27-30-14-20(28)24(32-27)18-6-4-16(29)12-21(18)37-3/h4-7,12-14H,8-11H2,1-3H3,(H,30,31,32) PYICIQOHSCQPIT-UHFFFAOYSA-N 50564823 CHEMBL4785627 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564823&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162668069 461685161 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51399079 CCCCNc1nc2ccc(cc2[nH]1)[N+]([O-])=O InChI=1S/C11H14N4O2/c1-2-3-6-12-11-13-9-5-4-8(15(16)17)7-10(9)14-11/h4-5,7H,2-3,6H2,1H3,(H2,12,13,14) KCMYEMHXIIFYLP-UHFFFAOYSA-N 50565166 CHEMBL4776698 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 480 ChEMBL 10.1016/j.ejmech.2020.112337 10.7270/Q2X92G13 32659605 Benchekroun, M; Ermolenko, L; Tran, MQ; Vagneux, A; Nedev, H; Delehouzé, C; Souab, M; Baratte, B; Josselin, B; Iorga, BI; Ruchaud, S; Bach, S; Al-Mourabit, A Universit£ Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565166&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 10823582 461685504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51399080 CCCCNc1nc2cc(ccc2s1)[N+]([O-])=O InChI=1S/C11H13N3O2S/c1-2-3-6-12-11-13-9-7-8(14(15)16)4-5-10(9)17-11/h4-5,7H,2-3,6H2,1H3,(H,12,13) KGMPZRJHVILPMZ-UHFFFAOYSA-N 50565177 CHEMBL4796622 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112337 10.7270/Q2X92G13 32659605 Benchekroun, M; Ermolenko, L; Tran, MQ; Vagneux, A; Nedev, H; Delehouzé, C; Souab, M; Baratte, B; Josselin, B; Iorga, BI; Ruchaud, S; Bach, S; Al-Mourabit, A Universit£ Paris-Saclay http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565177&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 101852844 461685515 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407091 CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C19H16FN5/c1-24(2)18-19-23-16(13-3-5-15(20)6-4-13)17(25(19)12-11-22-18)14-7-9-21-10-8-14/h3-12H,1-2H3 BTEXCOZQDANGMU-UHFFFAOYSA-N 50568538 CHEMBL3634367 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568538&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 122196052 471058683 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407092 CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1cccnc1 InChI=1S/C19H16FN5/c1-24(2)18-19-23-16(13-5-7-15(20)8-6-13)17(25(19)11-10-22-18)14-4-3-9-21-12-14/h3-12H,1-2H3 WDJAGABOAFSGMP-UHFFFAOYSA-N 50568533 CHEMBL4860515 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164616046 471058678 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407093 CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1cncnc1 InChI=1S/C18H15FN6/c1-24(2)17-18-23-15(12-3-5-14(19)6-4-12)16(25(18)8-7-22-17)13-9-20-11-21-10-13/h3-11H,1-2H3 OOFPPUBMQAMSBU-UHFFFAOYSA-N 50568534 CHEMBL4848621 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568534&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612080 471058679 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407094 CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1cnc(N)nc1 InChI=1S/C18H16FN7/c1-25(2)16-17-24-14(11-3-5-13(19)6-4-11)15(26(17)8-7-21-16)12-9-22-18(20)23-10-12/h3-10H,1-2H3,(H2,20,22,23) XDFWAKIRQLKZKR-UHFFFAOYSA-N 50568535 CHEMBL4871059 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568535&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164625255 471058680 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407095 CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2[nH]ncc2c1 InChI=1S/C21H17FN6/c1-27(2)20-21-25-18(13-3-6-16(22)7-4-13)19(28(21)10-9-23-20)14-5-8-17-15(11-14)12-24-26-17/h3-12H,1-2H3,(H,24,26) NCBFUZBLGICAPK-UHFFFAOYSA-N 50568536 CHEMBL4866187 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568536&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164619262 471058681 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407096 CN(C)c1nccn2c(-c3cnn(C)c3)c(nc12)-c1ccc(F)cc1 InChI=1S/C18H17FN6/c1-23(2)17-18-22-15(12-4-6-14(19)7-5-12)16(25(18)9-8-20-17)13-10-21-24(3)11-13/h4-11H,1-3H3 KASWNWVAOVGTLI-UHFFFAOYSA-N 50568537 CHEMBL4861720 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568537&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164611485 471058682 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407126 CSc1nccc(n1)-c1c(nc2c(Cl)nccn12)-c1ccccc1 InChI=1S/C17H12ClN5S/c1-24-17-20-8-7-12(21-17)14-13(11-5-3-2-4-6-11)22-16-15(18)19-9-10-23(14)16/h2-10H,1H3 VLJYQKOCIWRKQQ-UHFFFAOYSA-N 50568539 CHEMBL4875029 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568539&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164627897 471058684 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407127 CSc1nccc(n1)-c1c(nc2c(nccn12)N(C)C)-c1ccccc1 InChI=1S/C19H18N6S/c1-24(2)17-18-23-15(13-7-5-4-6-8-13)16(25(18)12-11-20-17)14-9-10-21-19(22-14)26-3/h4-12H,1-3H3 UQBCQWAPUAUXQU-UHFFFAOYSA-N 50568540 CHEMBL4872681 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568540&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164623558 471058685 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407128 CN(C)c1nccn2c(c(nc12)-c1ccccc1)-c1ccnc(N)n1 InChI=1S/C18H17N7/c1-24(2)16-17-23-14(12-6-4-3-5-7-12)15(25(17)11-10-20-16)13-8-9-21-18(19)22-13/h3-11H,1-2H3,(H2,19,21,22) LELKNWROXAPJEO-UHFFFAOYSA-N 50568541 CHEMBL4860872 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568541&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164614753 471058686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407129 CSc1nccc(n1)-c1c(nc2c(Cl)nccn12)-c1ccc(F)cc1 InChI=1S/C17H11ClFN5S/c1-25-17-21-7-6-12(22-17)14-13(10-2-4-11(19)5-3-10)23-16-15(18)20-8-9-24(14)16/h2-9H,1H3 UCMKMJNZULWNOQ-UHFFFAOYSA-N 50568542 CHEMBL4851634 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568542&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 57438768 471058687 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407130 CSc1nccc(n1)-c1c(nc2c(nccn12)N(C)C)-c1ccc(F)cc1 InChI=1S/C19H17FN6S/c1-25(2)17-18-24-15(12-4-6-13(20)7-5-12)16(26(18)11-10-21-17)14-8-9-22-19(23-14)27-3/h4-11H,1-3H3 PLILNLDCVRFBMR-UHFFFAOYSA-N 50568543 CHEMBL4875986 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 151475420 471058688 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407131 CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccnc(N)n1 InChI=1S/C18H16FN7/c1-25(2)16-17-24-14(11-3-5-12(19)6-4-11)15(26(17)10-9-21-16)13-7-8-22-18(20)23-13/h3-10H,1-2H3,(H2,20,22,23) JJUFPIADJDYDIT-UHFFFAOYSA-N 50568544 CHEMBL4870529 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568544&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164621127 471058689 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407132 CSc1nccc(n1)-c1c(nc2c(N)nccn12)-c1ccc(F)cc1 InChI=1S/C17H13FN6S/c1-25-17-21-7-6-12(22-17)14-13(10-2-4-11(18)5-3-10)23-16-15(19)20-8-9-24(14)16/h2-9H,1H3,(H2,19,20) VZXFJJIXYUECLL-UHFFFAOYSA-N 50568545 CHEMBL4877608 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568545&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626598 471058690 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51407133 Nc1nccc(n1)-c1c(nc2c(N)nccn12)-c1ccc(F)cc1 InChI=1S/C16H12FN7/c17-10-3-1-9(2-4-10)12-13(11-5-6-21-16(19)22-11)24-8-7-20-14(18)15(24)23-12/h1-8H,(H2,18,20)(H2,19,21,22) PXRMQQANTCUKMP-UHFFFAOYSA-N 50568546 CHEMBL4853288 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 500 ChEMBL 10.1016/j.ejmech.2020.112956 10.7270/Q2125XD2 33148491 Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cavé, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Späth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568546&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164617431 471058691 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411060 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCCC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C38H38FN9O8S/c1-56-29-19-23(39)12-13-25(29)34-42-21-43-38(46-34)44-24-7-3-6-22(18-24)20-57(2,55)47-32(51)11-5-10-30(49)41-17-16-40-27-9-4-8-26-33(27)37(54)48(36(26)53)28-14-15-31(50)45-35(28)52/h3-4,6-9,12-13,18-19,21,28,40H,5,10-11,14-17,20H2,1-2H3,(H,41,49)(H,45,50,52)(H,42,43,44,46) FKEMWSGVFNPMLM-UHFFFAOYSA-N 50570059 CHEMBL4855746 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570059&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164616945 471060204 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411061 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCCCCC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C40H42FN9O8S/c1-58-31-21-25(41)14-15-27(31)36-44-23-45-40(48-36)46-26-9-6-8-24(20-26)22-59(2,57)49-34(53)13-5-3-4-12-32(51)43-19-18-42-29-11-7-10-28-35(29)39(56)50(38(28)55)30-16-17-33(52)47-37(30)54/h6-11,14-15,20-21,23,30,42H,3-5,12-13,16-19,22H2,1-2H3,(H,43,51)(H,47,52,54)(H,44,45,46,48) WXRXZJOVLMBRSB-UHFFFAOYSA-N 50570060 CHEMBL4874407 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570060&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626973 471060205 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411062 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCCCCCCC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C42H46FN9O8S/c1-60-33-23-27(43)16-17-29(33)38-46-25-47-42(50-38)48-28-11-8-10-26(22-28)24-61(2,59)51-36(55)15-7-5-3-4-6-14-34(53)45-21-20-44-31-13-9-12-30-37(31)41(58)52(40(30)57)32-18-19-35(54)49-39(32)56/h8-13,16-17,22-23,25,32,44H,3-7,14-15,18-21,24H2,1-2H3,(H,45,53)(H,49,54,56)(H,46,47,48,50) SRVYTIFEXUTLAJ-UHFFFAOYSA-N 50570061 CHEMBL4854353 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.7 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570061&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613470 471060206 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411063 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCCCCCCCCC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C44H50FN9O8S/c1-62-35-25-29(45)18-19-31(35)40-48-27-49-44(52-40)50-30-13-10-12-28(24-30)26-63(2,61)53-38(57)17-9-7-5-3-4-6-8-16-36(55)47-23-22-46-33-15-11-14-32-39(33)43(60)54(42(32)59)34-20-21-37(56)51-41(34)58/h10-15,18-19,24-25,27,34,46H,3-9,16-17,20-23,26H2,1-2H3,(H,47,55)(H,51,56,58)(H,48,49,50,52) BJXYQTYEYRAXOM-UHFFFAOYSA-N 50570062 CHEMBL4848136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570062&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613243 471060207 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411064 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCC(=O)CCC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C40H40FN9O9S/c1-59-31-20-24(41)9-12-27(31)36-44-22-45-40(48-36)46-25-6-3-5-23(19-25)21-60(2,58)49-34(54)15-11-26(51)10-14-32(52)43-18-17-42-29-8-4-7-28-35(29)39(57)50(38(28)56)30-13-16-33(53)47-37(30)55/h3-9,12,19-20,22,30,42H,10-11,13-18,21H2,1-2H3,(H,43,52)(H,47,53,55)(H,44,45,46,48) PSEKFHGSBAMIAE-UHFFFAOYSA-N 50570063 CHEMBL4850946 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570063&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164610614 471060208 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411065 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCC(=O)CCC(=O)NCCCCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C43H46FN9O9S/c1-62-34-23-27(44)12-15-30(34)39-47-25-48-43(51-39)49-28-9-6-8-26(22-28)24-63(2,61)52-37(57)18-14-29(54)13-17-35(55)46-21-5-3-4-20-45-32-11-7-10-31-38(32)42(60)53(41(31)59)33-16-19-36(56)50-40(33)58/h6-12,15,22-23,25,33,45H,3-5,13-14,16-21,24H2,1-2H3,(H,46,55)(H,50,56,58)(H,47,48,49,51) XZHIMUOLKIPBKA-UHFFFAOYSA-N 50570064 CHEMBL4863429 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570064&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624890 471060209 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411066 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCCCCC(=O)NCCCCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C43H48FN9O8S/c1-61-34-24-28(44)17-18-30(34)39-47-26-48-43(51-39)49-29-12-9-11-27(23-29)25-62(2,60)52-37(56)16-6-3-5-15-35(54)46-22-8-4-7-21-45-32-14-10-13-31-38(32)42(59)53(41(31)58)33-19-20-36(55)50-40(33)57/h9-14,17-18,23-24,26,33,45H,3-8,15-16,19-22,25H2,1-2H3,(H,46,54)(H,50,55,57)(H,47,48,49,51) CJABJKHMLIRNNF-UHFFFAOYSA-N 50570065 CHEMBL4849457 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570065&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612107 471060210 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411067 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)COCCOCCOCC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C41H44FN9O11S/c1-59-32-20-26(42)9-10-28(32)37-45-24-46-41(49-37)47-27-6-3-5-25(19-27)23-63(2,58)50-35(54)22-62-18-16-60-15-17-61-21-34(53)44-14-13-43-30-8-4-7-29-36(30)40(57)51(39(29)56)31-11-12-33(52)48-38(31)55/h3-10,19-20,24,31,43H,11-18,21-23H2,1-2H3,(H,44,53)(H,48,52,55)(H,45,46,47,49) AIYUXSKIUKFZIR-UHFFFAOYSA-N 50570066 CHEMBL4856897 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570066&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164609770 471060211 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411068 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)COCCOCCOCC(=O)NCCCCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c2)n1 InChI=1S/C44H50FN9O11S/c1-62-35-23-29(45)12-13-31(35)40-48-27-49-44(52-40)50-30-9-6-8-28(22-30)26-66(2,61)53-38(57)25-65-21-19-63-18-20-64-24-37(56)47-17-5-3-4-16-46-33-11-7-10-32-39(33)43(60)54(42(32)59)34-14-15-36(55)51-41(34)58/h6-13,22-23,27,34,46H,3-5,14-21,24-26H2,1-2H3,(H,47,56)(H,51,55,58)(H,48,49,50,52) XENCJIFLJHOJNF-UHFFFAOYSA-N 50570067 CHEMBL4863414 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.4 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570067&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624469 471060212 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411069 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCc3cn(CCCCCC(=O)NCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)nn3)c2)n1 InChI=1S/C44H47FN12O8S/c1-65-35-23-28(45)13-15-31(35)40-48-26-49-44(52-40)50-29-9-6-8-27(22-29)25-66(2,64)54-38(60)17-14-30-24-56(55-53-30)21-5-3-4-12-36(58)47-20-19-46-33-11-7-10-32-39(33)43(63)57(42(32)62)34-16-18-37(59)51-41(34)61/h6-11,13,15,22-24,26,34,46H,3-5,12,14,16-21,25H2,1-2H3,(H,47,58)(H,51,59,61)(H,48,49,50,52) SVLFYFARCDFEET-UHFFFAOYSA-N 50570068 CHEMBL4876195 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570068&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164625736 471060213 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411070 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=NC(=O)CCc3cn(CCCCCCCC(=O)NCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)nn3)c2)n1 InChI=1S/C46H51FN12O8S/c1-67-37-25-30(47)15-17-33(37)42-50-28-51-46(54-42)52-31-11-8-10-29(24-31)27-68(2,66)56-40(62)19-16-32-26-58(57-55-32)23-7-5-3-4-6-14-38(60)49-22-21-48-35-13-9-12-34-41(35)45(65)59(44(34)64)36-18-20-39(61)53-43(36)63/h8-13,15,17,24-26,28,36,48H,3-7,14,16,18-23,27H2,1-2H3,(H,49,60)(H,53,61,63)(H,50,51,52,54) PYHFRPQJHUMRSC-UHFFFAOYSA-N 50570069 CHEMBL4867961 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.3 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570069&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164622329 471060214 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411071 COc1cc(ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1)N1CCN(CCCCCC(=O)NCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1 InChI=1S/C43H51N11O7S/c1-61-35-25-30(13-14-31(35)39-47-27-48-43(51-39)49-29-9-6-8-28(24-29)26-62(2,44)60)53-22-20-52(21-23-53)19-5-3-4-12-36(55)46-18-17-45-33-11-7-10-32-38(33)42(59)54(41(32)58)34-15-16-37(56)50-40(34)57/h6-11,13-14,24-25,27,34,44-45H,3-5,12,15-23,26H2,1-2H3,(H,46,55)(H,50,56,57)(H,47,48,49,51) POIMPOREAXYADR-UHFFFAOYSA-N 50570070 CHEMBL4875148 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8114 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570070&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164629058 471060215 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411072 COc1cc(ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1)N1CCN(CCCCCCC(=O)NCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1 InChI=1S/C44H53N11O7S/c1-62-36-26-31(14-15-32(36)40-48-28-49-44(52-40)50-30-10-7-9-29(25-30)27-63(2,45)61)54-23-21-53(22-24-54)20-6-4-3-5-13-37(56)47-19-18-46-34-12-8-11-33-39(34)43(60)55(42(33)59)35-16-17-38(57)51-41(35)58/h7-12,14-15,25-26,28,35,45-46H,3-6,13,16-24,27H2,1-2H3,(H,47,56)(H,51,57,58)(H,48,49,50,52) SQWKPRWGMZGAEX-UHFFFAOYSA-N 50570071 CHEMBL4849324 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6564 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570071&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164616676 471060216 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411073 COc1cc(ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1)N1CCN(CCCCCCCC(=O)NCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1 InChI=1S/C45H55N11O7S/c1-63-37-27-32(15-16-33(37)41-49-29-50-45(53-41)51-31-11-8-10-30(26-31)28-64(2,46)62)55-24-22-54(23-25-55)21-7-5-3-4-6-14-38(57)48-20-19-47-35-13-9-12-34-40(35)44(61)56(43(34)60)36-17-18-39(58)52-42(36)59/h8-13,15-16,26-27,29,36,46-47H,3-7,14,17-25,28H2,1-2H3,(H,48,57)(H,52,58,59)(H,49,50,51,53) NGHBPZJJGXXZEO-UHFFFAOYSA-N 50570072 CHEMBL4877208 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6870 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570072&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626589 471060217 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411074 COc1cc(ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1)N1CCN(CCCCCCCCCC(=O)NCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1 InChI=1S/C47H59N11O7S/c1-65-39-29-34(17-18-35(39)43-51-31-52-47(55-43)53-33-13-10-12-32(28-33)30-66(2,48)64)57-26-24-56(25-27-57)23-9-7-5-3-4-6-8-16-40(59)50-22-21-49-37-15-11-14-36-42(37)46(63)58(45(36)62)38-19-20-41(60)54-44(38)61/h10-15,17-18,28-29,31,38,48-49H,3-9,16,19-27,30H2,1-2H3,(H,50,59)(H,54,60,61)(H,51,52,53,55) VXZHEHTYQPJJMH-UHFFFAOYSA-N 50570073 CHEMBL4847206 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6337 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570073&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613216 471060218 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411075 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) ACWKGTGIJRCOOM-UHFFFAOYSA-N 168383 US9669034, 2 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.1016/j.ejmech.2020.113091 10.7270/Q2ZP49W3 33338869 Qiu, X; Li, Y; Yu, B; Ren, J; Huang, H; Wang, M; Ding, H; Li, Z; Wang, J; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618220 373987116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419847 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7-22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1 RUBYHLPRZRMTJO-MOVYNIQHSA-N 50528813 CHEMBL4163879 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 193 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528813&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118025540 440737395 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419848 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Br)c(n1)-c1c[nH]c2ccccc12 50573503 CHEMBL4862603 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 184 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573503&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164623114 471063648 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419849 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(C2CC2)c(n1)-c1c[nH]c2ccccc12 50573504 CHEMBL4848336 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573504&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164611038 471063649 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419850 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2ccccc12)C(F)(F)F 50573505 CHEMBL4854583 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573505&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615138 471063650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419851 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573506 CHEMBL4861833 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573506&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 118025416 471063651 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419852 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573507 CHEMBL4870659 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1220 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573507&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164625238 471063652 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419853 CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573508 CHEMBL4787545 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 658 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573508&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134560546 471063653 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419854 Clc1cnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cn2)nc1-c1c[nH]c2ccccc12 50573509 CHEMBL4758566 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 530 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573509&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134560346 471063654 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419855 CN(C)C\C=C\C(=O)Nc1ccc(cc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573510 CHEMBL4866812 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 155 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573510&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134543415 471063655 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419856 C\C=C\C(=O)Nc1ccc(cc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573511 CHEMBL4864697 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 171 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573511&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164621718 471063656 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419857 CN(C)C\C=C\C(=O)Nc1ccc(nc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573512 CHEMBL4748005 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 88 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573512&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134543949 471063657 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419858 C\C=C\C(=O)Nc1ccc(nc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573513 CHEMBL4866757 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 121 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573513&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164620575 471063658 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419859 C\C=C\C(=O)Nc1ccc(cc1C)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573514 CHEMBL4860981 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 165 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573514&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612563 471063659 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419860 C\C=C\C(=O)Nc1ccc(N2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1 50573515 CHEMBL4853887 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 436 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612914 471063660 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419861 C\C=C\C(=O)Nc1cc(F)c(cc1C)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573516 CHEMBL4853964 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 230 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573516&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615728 471063661 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419862 COc1cc(NC(=O)\C=C\C)c(C)cc1N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573517 CHEMBL4872216 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 522 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573517&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164619029 471063662 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419863 CN(C)C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573518 CHEMBL4754873 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 367 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search UUB 7NXK 134560325 471063663 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419864 C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573519 CHEMBL4862643 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 585 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573519&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164623631 471063664 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419865 CN(C)C\C=C\C(=O)Nc1ccc(O[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573520 CHEMBL4862284 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 132 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134560314 471063665 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51419866 CN(C)C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1 50573521 CHEMBL4753819 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 286 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 134560316 471063666 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411529 CNc1nc(C)c(s1)-c1nc(Nc2cccc(O)c2)ncc1C#N InChI=1S/C16H14N6OS/c1-9-14(24-16(18-2)20-9)13-10(7-17)8-19-15(22-13)21-11-4-3-5-12(23)6-11/h3-6,8,23H,1-2H3,(H,18,20)(H,19,21,22) NYRVLHGVDPPWJS-UHFFFAOYSA-N 50425005 CHEMBL2312188 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425005&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search T9N 4BCN,4BCJ 44253187 164153880 CHEMBL2312188 ZINC95596931 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411530 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(C)CC2)ncc1Cl InChI=1S/C20H24ClN7S/c1-13-18(29-20(22-2)24-13)17-16(21)12-23-19(26-17)25-14-5-4-6-15(11-14)28-9-7-27(3)8-10-28/h4-6,11-12H,7-10H2,1-3H3,(H,22,24)(H,23,25,26) CSIAVORBNYKYNX-UHFFFAOYSA-N 50570294 CHEMBL4855334 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570294&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164617495 471060439 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411531 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCOCC2)ncc1Cl InChI=1S/C19H21ClN6OS/c1-12-17(28-19(21-2)23-12)16-15(20)11-22-18(25-16)24-13-4-3-5-14(10-13)26-6-8-27-9-7-26/h3-5,10-11H,6-9H2,1-2H3,(H,21,23)(H,22,24,25) PUBSTGHGWFWUTL-UHFFFAOYSA-N 50570295 CHEMBL4854124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570295&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164616271 471060440 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411532 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCOCC2)ncc1C InChI=1S/C20H24N6OS/c1-13-12-22-19(25-17(13)18-14(2)23-20(21-3)28-18)24-15-5-4-6-16(11-15)26-7-9-27-10-8-26/h4-6,11-12H,7-10H2,1-3H3,(H,21,23)(H,22,24,25) ZIUVOODMQVKJEA-UHFFFAOYSA-N 50570296 CHEMBL4863124 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570296&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624460 471060441 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411533 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1C InChI=1S/C22H27N7OS/c1-14-13-24-21(27-19(14)20-15(2)25-22(23-4)31-20)26-17-6-5-7-18(12-17)29-10-8-28(9-11-29)16(3)30/h5-7,12-13H,8-11H2,1-4H3,(H,23,25)(H,24,26,27) ABMHADFXETUEKB-UHFFFAOYSA-N 50570297 CHEMBL4847674 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570297&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612631 471060442 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411534 CC(=O)N1CCN(CC1)c1cccc(Nc2ncc3CCc4nc(N)sc4-c3n2)c1 InChI=1S/C21H23N7OS/c1-13(29)27-7-9-28(10-8-27)16-4-2-3-15(11-16)24-21-23-12-14-5-6-17-19(18(14)26-21)30-20(22)25-17/h2-4,11-12H,5-10H2,1H3,(H2,22,25)(H,23,24,26) OZPGXTWXUQVREL-UHFFFAOYSA-N 50570298 CHEMBL4875788 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570298&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626165 471060443 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411535 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1C InChI=1S/C20H25N7S/c1-13-12-23-19(26-17(13)18-14(2)24-20(21-3)28-18)25-15-5-4-6-16(11-15)27-9-7-22-8-10-27/h4-6,11-12,22H,7-10H2,1-3H3,(H,21,24)(H,23,25,26) GZDFPDSMIHMTRU-UHFFFAOYSA-N 50570299 CHEMBL4879020 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164629222 471060444 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411536 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(C)CC2)ncc1C InChI=1S/C21H27N7S/c1-14-13-23-20(26-18(14)19-15(2)24-21(22-3)29-19)25-16-6-5-7-17(12-16)28-10-8-27(4)9-11-28/h5-7,12-13H,8-11H2,1-4H3,(H,22,24)(H,23,25,26) TZUWFXHCJVWHSH-UHFFFAOYSA-N 50570300 CHEMBL4849252 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570300&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613869 471060445 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411537 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)S(C)(=O)=O)ncc1C InChI=1S/C21H27N7O2S2/c1-14-13-23-20(26-18(14)19-15(2)24-21(22-3)31-19)25-16-6-5-7-17(12-16)27-8-10-28(11-9-27)32(4,29)30/h5-7,12-13H,8-11H2,1-4H3,(H,22,24)(H,23,25,26) BSUDUKKQFRGZBK-UHFFFAOYSA-N 50570301 CHEMBL4868287 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570301&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164618875 471060446 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411538 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1C InChI=1S/C21H27N7S/c1-14-13-24-20(27-18(14)19-15(2)25-21(22-3)29-19)26-16-6-4-7-17(12-16)28-10-5-8-23-9-11-28/h4,6-7,12-13,23H,5,8-11H2,1-3H3,(H,22,25)(H,24,26,27) DIHQGMJAKVBZHN-UHFFFAOYSA-N 50570302 CHEMBL4853628 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570302&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612906 471060447 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411539 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNC(=O)CC2)ncc1C InChI=1S/C21H25N7OS/c1-13-12-24-20(27-18(13)19-14(2)25-21(22-3)30-19)26-15-5-4-6-16(11-15)28-9-7-17(29)23-8-10-28/h4-6,11-12H,7-10H2,1-3H3,(H,22,25)(H,23,29)(H,24,26,27) REOUVJBYQCRCTD-UHFFFAOYSA-N 50570303 CHEMBL4864728 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570303&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164622682 471060448 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411540 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN3CCC2CC3)ncc1C InChI=1S/C23H29N7S/c1-15-14-25-22(28-20(15)21-16(2)26-23(24-3)31-21)27-17-5-4-6-19(13-17)30-12-11-29-9-7-18(30)8-10-29/h4-6,13-14,18H,7-12H2,1-3H3,(H,24,26)(H,25,27,28) RSTOVEUALSXORR-UHFFFAOYSA-N 50570304 CHEMBL4860925 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570304&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612545 471060449 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411541 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1C(F)(F)F InChI=1S/C22H24F3N7OS/c1-13-19(34-21(26-3)28-13)18-17(22(23,24)25)12-27-20(30-18)29-15-5-4-6-16(11-15)32-9-7-31(8-10-32)14(2)33/h4-6,11-12H,7-10H2,1-3H3,(H,26,28)(H,27,29,30) DUNQXJMGVWJHTJ-UHFFFAOYSA-N 50570305 CHEMBL4876374 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 95 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570305&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164629118 471060450 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411542 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1C(F)(F)F InChI=1S/C20H22F3N7S/c1-12-17(31-19(24-2)27-12)16-15(20(21,22)23)11-26-18(29-16)28-13-4-3-5-14(10-13)30-8-6-25-7-9-30/h3-5,10-11,25H,6-9H2,1-2H3,(H,24,27)(H,26,28,29) NNVQFONYTZIEBC-UHFFFAOYSA-N 50570306 CHEMBL4873661 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 49 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570306&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164620769 471060451 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411543 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCOCC2)ncc1C=C InChI=1S/C21H24N6OS/c1-4-15-13-23-20(26-18(15)19-14(2)24-21(22-3)29-19)25-16-6-5-7-17(12-16)27-8-10-28-11-9-27/h4-7,12-13H,1,8-11H2,2-3H3,(H,22,24)(H,23,25,26) KEMDKRATVFSGJN-UHFFFAOYSA-N 50570307 CHEMBL4852571 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570307&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613404 471060452 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411544 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1Br InChI=1S/C21H24BrN7OS/c1-13-19(31-21(23-3)25-13)18-17(22)12-24-20(27-18)26-15-5-4-6-16(11-15)29-9-7-28(8-10-29)14(2)30/h4-6,11-12H,7-10H2,1-3H3,(H,23,25)(H,24,26,27) JJUAVZQHRBSKOY-UHFFFAOYSA-N 50570308 CHEMBL4863865 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.5 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570308&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164621328 471060453 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411545 CNc1nc(c(s1)-c1ccnc(Nc2cccc(c2)N2CCCNCC2)n1)C(F)(F)F InChI=1S/C20H22F3N7S/c1-24-19-29-17(20(21,22)23)16(31-19)15-6-8-26-18(28-15)27-13-4-2-5-14(12-13)30-10-3-7-25-9-11-30/h2,4-6,8,12,25H,3,7,9-11H2,1H3,(H,24,29)(H,26,27,28) PSNUTPHNERQRHY-UHFFFAOYSA-N 50570309 CHEMBL4868954 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570309&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164619765 471060454 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411546 CNc1ncc(s1)-c1ccnc(Nc2cccc(c2)N2CCCNCC2)n1 InChI=1S/C19H23N7S/c1-20-19-23-13-17(27-19)16-6-8-22-18(25-16)24-14-4-2-5-15(12-14)26-10-3-7-21-9-11-26/h2,4-6,8,12-13,21H,3,7,9-11H2,1H3,(H,20,23)(H,22,24,25) XCIGDMLFQKYLKU-UHFFFAOYSA-N 50570310 CHEMBL4876861 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570310&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164627469 471060455 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411547 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2cccc(c2)C(=O)NC2CCN(C)CC2)n1 InChI=1S/C24H29N7OS/c1-25-24-30-20(15-6-7-15)21(33-24)19-8-11-26-23(29-19)28-18-5-3-4-16(14-18)22(32)27-17-9-12-31(2)13-10-17/h3-5,8,11,14-15,17H,6-7,9-10,12-13H2,1-2H3,(H,25,30)(H,27,32)(H,26,28,29) JANDQTUCESQHRD-UHFFFAOYSA-N 50570311 CHEMBL4867016 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570311&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164620942 471060456 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411548 CNc1nc(C(C)C)c(s1)-c1ccnc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)n1 InChI=1S/C23H29N7OS/c1-15(2)20-21(32-23(24-4)28-20)19-8-9-25-22(27-19)26-17-6-5-7-18(14-17)30-12-10-29(11-13-30)16(3)31/h5-9,14-15H,10-13H2,1-4H3,(H,24,28)(H,25,26,27) KHXBENXTIWTHLB-UHFFFAOYSA-N 50570312 CHEMBL4851014 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 91 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570312&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613351 471060457 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411549 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)n1 InChI=1S/C21H25N7OS/c1-14-19(30-21(22-3)24-14)18-7-8-23-20(26-18)25-16-5-4-6-17(13-16)28-11-9-27(10-12-28)15(2)29/h4-8,13H,9-12H2,1-3H3,(H,22,24)(H,23,25,26) ZOMIHFOYONJRJB-UHFFFAOYSA-N 50570313 CHEMBL4868705 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570313&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 11575426 471060458 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411550 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCCCC2)ncc1C#N InChI=1S/C22H25N7S/c1-15-20(30-22(24-2)26-15)19-16(13-23)14-25-21(28-19)27-17-8-7-9-18(12-17)29-10-5-3-4-6-11-29/h7-9,12,14H,3-6,10-11H2,1-2H3,(H,24,26)(H,25,27,28) HQELVOAHMYHJLJ-UHFFFAOYSA-N 50570314 CHEMBL4847048 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570314&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 158555063 471060459 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411551 CNc1nc(C)c(s1)-c1nc(Nc2cc(C)cc(c2)N2CCCCCC2)ncc1C#N InChI=1S/C23H27N7S/c1-15-10-18(12-19(11-15)30-8-6-4-5-7-9-30)28-22-26-14-17(13-24)20(29-22)21-16(2)27-23(25-3)31-21/h10-12,14H,4-9H2,1-3H3,(H,25,27)(H,26,28,29) MTJJCZRPNOKRPO-UHFFFAOYSA-N 50570315 CHEMBL4845688 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570315&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164608872 471060460 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411552 CNc1nc(C)c(s1)-c1nc(Nc2cc(C)cc(c2)N2CCNCC2)ncc1C#N InChI=1S/C21H24N8S/c1-13-8-16(10-17(9-13)29-6-4-24-5-7-29)27-20-25-12-15(11-22)18(28-20)19-14(2)26-21(23-3)30-19/h8-10,12,24H,4-7H2,1-3H3,(H,23,26)(H,25,27,28) RHBXOKIMSCJPEB-UHFFFAOYSA-N 50570316 CHEMBL4864851 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570316&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164619207 471060461 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411553 CNc1nc(C)c(s1)-c1nc(Nc2cc(C)cc(c2)N2CCOCC2)ncc1C#N InChI=1S/C21H23N7OS/c1-13-8-16(10-17(9-13)28-4-6-29-7-5-28)26-20-24-12-15(11-22)18(27-20)19-14(2)25-21(23-3)30-19/h8-10,12H,4-7H2,1-3H3,(H,23,25)(H,24,26,27) ZIPADUJETRCYRU-UHFFFAOYSA-N 50570317 CHEMBL4863915 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570317&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624914 471060462 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411554 CNc1nc(C)c(s1)-c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1 InChI=1S/C23H29N7O2S/c1-16-21(33-23(24-2)26-16)20-3-4-25-22(28-20)27-17-13-18(29-5-9-31-10-6-29)15-19(14-17)30-7-11-32-12-8-30/h3-4,13-15H,5-12H2,1-2H3,(H,24,26)(H,25,27,28) QFUODDQEGUEMEC-UHFFFAOYSA-N 50570318 CHEMBL4856525 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570318&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613025 471060463 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411555 CNc1nc(C)c(s1)-c1ccnc(Nc2cc(cc(c2)N2CCN(CC2)C(C)=O)N2CCN(CC2)C(C)=O)n1 InChI=1S/C27H35N9O2S/c1-18-25(39-27(28-4)30-18)24-5-6-29-26(32-24)31-21-15-22(35-11-7-33(8-12-35)19(2)37)17-23(16-21)36-13-9-34(10-14-36)20(3)38/h5-6,15-17H,7-14H2,1-4H3,(H,28,30)(H,29,31,32) ATBUIESAGWERGG-UHFFFAOYSA-N 50570319 CHEMBL4871982 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 187 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570319&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624310 471060464 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411556 CNc1nc(C)c(s1)-c1nc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)ncc1C#N InChI=1S/C24H28N8O2S/c1-16-22(35-24(26-2)28-16)21-17(14-25)15-27-23(30-21)29-18-11-19(31-3-7-33-8-4-31)13-20(12-18)32-5-9-34-10-6-32/h11-13,15H,3-10H2,1-2H3,(H,26,28)(H,27,29,30) XHAWHVHQZTVHLI-UHFFFAOYSA-N 50570320 CHEMBL4863852 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.0 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570320&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164620483 471060465 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411557 CNc1nc(C)c(s1)-c1nc(Nc2cc(cc(c2)N2CCN(CC2)C(C)=O)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C28H34N10O2S/c1-18-26(41-28(30-4)32-18)25-21(16-29)17-31-27(34-25)33-22-13-23(37-9-5-35(6-10-37)19(2)39)15-24(14-22)38-11-7-36(8-12-38)20(3)40/h13-15,17H,5-12H2,1-4H3,(H,30,32)(H,31,33,34) VCGZLNSADOXLAT-UHFFFAOYSA-N 50570321 CHEMBL4851366 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570321&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164614479 471060466 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51411558 CNc1nc(C)c(s1)-c1nc(Nc2cc(cc(c2)N2CCN(CC2)C(C)=O)N2CCN(CC2)C(C)=O)ncc1C InChI=1S/C28H37N9O2S/c1-18-17-30-27(33-25(18)26-19(2)31-28(29-5)40-26)32-22-14-23(36-10-6-34(7-11-36)20(3)38)16-24(15-22)37-12-8-35(9-13-37)21(4)39/h14-17H,6-13H2,1-5H3,(H,29,31)(H,30,32,33) BFQURZQIPAVHMX-UHFFFAOYSA-N 50570322 CHEMBL4850846 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570322&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615592 471060467 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51427349 Fc1cc2[nH]ncc2c2c3CCCCc3c(nc12)-c1c[nH]nc1C(F)(F)F InChI=1S/C18H13F4N5/c19-12-5-13-10(6-23-26-13)14-8-3-1-2-4-9(8)15(25-16(12)14)11-7-24-27-17(11)18(20,21)22/h5-7H,1-4H2,(H,23,26)(H,24,27) QZEZKSMIUTYGRU-UHFFFAOYSA-N 50576556 CHEMBL4856733 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 538 ChEMBL 10.1021/acs.jmedchem.1c00330 10.7270/Q2862M9D 34288692 Dayal, N; Řezníčková, E; Hernandez, DE; Peřina, M; Torregrosa-Allen, S; Elzey, BD; Škerlová, J; Ajani, H; Djukic, S; Vojáčková, V; Lepšík, M; Řezáčová, P; Kryštof, V; Jorda, R; Sintim, HO Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153521586 471052679 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51427350 Fc1cc2[nH]ncc2c2c3CCCCc3c(nc12)-c1cn[nH]c1 InChI=1S/C17H14FN5/c18-13-5-14-12(8-21-23-14)15-10-3-1-2-4-11(10)16(22-17(13)15)9-6-19-20-7-9/h5-8H,1-4H2,(H,19,20)(H,21,23) QAWBPBLABQUSRL-UHFFFAOYSA-N 50576558 CHEMBL4873799 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 196 ChEMBL 10.1021/acs.jmedchem.1c00330 10.7270/Q2862M9D 34288692 Dayal, N; Řezníčková, E; Hernandez, DE; Peřina, M; Torregrosa-Allen, S; Elzey, BD; Škerlová, J; Ajani, H; Djukic, S; Vojáčková, V; Lepšík, M; Řezáčová, P; Kryštof, V; Jorda, R; Sintim, HO Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153521584 471052681 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51427351 Fc1cc2[nH]ncc2c2c3C4CCC(C4)c3c(nc12)-c1c[nH]nc1C(F)(F)F InChI=1S/C19H11F4N5/c20-11-4-12-9(5-24-27-12)15-13-7-1-2-8(3-7)14(13)16(26-17(11)15)10-6-25-28-18(10)19(21,22)23/h4-8H,1-3H2/b16-10- QEBUCKMOAFGBOZ-YBEGLDIGSA-N 50576559 CHEMBL4864901 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 980 ChEMBL 10.1021/acs.jmedchem.1c00330 10.7270/Q2862M9D 34288692 Dayal, N; Řezníčková, E; Hernandez, DE; Peřina, M; Torregrosa-Allen, S; Elzey, BD; Škerlová, J; Ajani, H; Djukic, S; Vojáčková, V; Lepšík, M; Řezáčová, P; Kryštof, V; Jorda, R; Sintim, HO Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155151802 471052682 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51427352 OCc1n[nH]c2ccc3nc(-c4c[nH]nc4C(F)(F)F)c4CCCCc4c3c12 InChI=1S/C19H16F3N5O/c20-19(21,22)18-11(7-23-27-18)17-10-4-2-1-3-9(10)15-12(24-17)5-6-13-16(15)14(8-28)26-25-13/h5-7,28H,1-4,8H2,(H,23,27)(H,25,26) QWFWQJOFUNDIAZ-UHFFFAOYSA-N 50576570 CHEMBL4871182 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c00330 10.7270/Q2862M9D 34288692 Dayal, N; Řezníčková, E; Hernandez, DE; Peřina, M; Torregrosa-Allen, S; Elzey, BD; Škerlová, J; Ajani, H; Djukic, S; Vojáčková, V; Lepšík, M; Řezáčová, P; Kryštof, V; Jorda, R; Sintim, HO Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 153521568 471052693 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51427353 Cc1n[nH]c2ccc3nc(-c4c[nH]nc4C(F)(F)F)c4CCCCc4c3c12 InChI=1S/C19H16F3N5/c1-9-15-14(26-25-9)7-6-13-16(15)10-4-2-3-5-11(10)17(24-13)12-8-23-27-18(12)19(20,21)22/h6-8H,2-5H2,1H3,(H,23,27)(H,25,26) LHVFNERWJYBEJN-UHFFFAOYSA-N 50576572 CHEMBL4856135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c00330 10.7270/Q2862M9D 34288692 Dayal, N; Řezníčková, E; Hernandez, DE; Peřina, M; Torregrosa-Allen, S; Elzey, BD; Škerlová, J; Ajani, H; Djukic, S; Vojáčková, V; Lepšík, M; Řezáčová, P; Kryštof, V; Jorda, R; Sintim, HO Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 150939945 471052695 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51427354 Cc1n[nH]c2cc(F)c3nc(-c4c[nH]nc4C(F)(F)F)c4CCCCc4c3c12 InChI=1S/C19H15F4N5/c1-8-14-13(27-26-8)6-12(20)17-15(14)9-4-2-3-5-10(9)16(25-17)11-7-24-28-18(11)19(21,22)23/h6-7H,2-5H2,1H3,(H,24,28)(H,26,27) PHLVHKVYPBUWOL-UHFFFAOYSA-N 50576576 CHEMBL4869569 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c00330 10.7270/Q2862M9D 34288692 Dayal, N; Řezníčková, E; Hernandez, DE; Peřina, M; Torregrosa-Allen, S; Elzey, BD; Škerlová, J; Ajani, H; Djukic, S; Vojáčková, V; Lepšík, M; Řezáčová, P; Kryštof, V; Jorda, R; Sintim, HO Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576576&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155151783 471052699 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420835 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3cccc4ccoc34)cc2oc1=O InChI=1S/C27H22N4O5/c1-16(32)23-24(31-10-13-34-14-11-31)20-6-5-18(15-22(20)36-26(23)33)29-27-28-9-7-21(30-27)19-4-2-3-17-8-12-35-25(17)19/h2-9,12,15H,10-11,13-14H2,1H3,(H,28,29,30) LLMHKWNNEVUJQC-UHFFFAOYSA-N 50573931 CHEMBL4858848 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 932 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162515861 471064076 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420836 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3cccc4OCOc34)cc2oc1=O InChI=1S/C26H22N4O6/c1-15(31)22-23(30-9-11-33-12-10-30)18-6-5-16(13-21(18)36-25(22)32)28-26-27-8-7-19(29-26)17-3-2-4-20-24(17)35-14-34-20/h2-8,13H,9-12,14H2,1H3,(H,27,28,29) FSYCNCQFHMRRPQ-UHFFFAOYSA-N 50573932 CHEMBL4856566 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 194 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573932&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164614643 471064077 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420837 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3cccc4cc[nH]c34)cc2oc1=O InChI=1S/C27H23N5O4/c1-16(33)23-25(32-11-13-35-14-12-32)20-6-5-18(15-22(20)36-26(23)34)30-27-29-10-8-21(31-27)19-4-2-3-17-7-9-28-24(17)19/h2-10,15,28H,11-14H2,1H3,(H,29,30,31) MHOTWRIRWZFVHQ-UHFFFAOYSA-N 50573933 CHEMBL4849424 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164610538 471064078 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420838 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4[nH]ccc4c3)cc2oc1=O InChI=1S/C27H23N5O4/c1-16(33)24-25(32-10-12-35-13-11-32)20-4-3-19(15-23(20)36-26(24)34)30-27-29-9-7-22(31-27)17-2-5-21-18(14-17)6-8-28-21/h2-9,14-15,28H,10-13H2,1H3,(H,29,30,31) GQDJDUAXXARZBU-UHFFFAOYSA-N 50573934 CHEMBL4877186 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 102 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626211 471064079 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420839 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4nccn4c3)cc2oc1=O InChI=1S/C26H22N6O4/c1-16(33)23-24(31-10-12-35-13-11-31)19-4-3-18(14-21(19)36-25(23)34)29-26-28-7-6-20(30-26)17-2-5-22-27-8-9-32(22)15-17/h2-9,14-15H,10-13H2,1H3,(H,28,29,30) XVSSUIHCKLQWKZ-UHFFFAOYSA-N 50573935 CHEMBL4849528 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 113 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573935&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613881 471064080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420840 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4ocnc4c3)cc2oc1=O InChI=1S/C26H21N5O5/c1-15(32)23-24(31-8-10-34-11-9-31)18-4-3-17(13-22(18)36-25(23)33)29-26-27-7-6-19(30-26)16-2-5-21-20(12-16)28-14-35-21/h2-7,12-14H,8-11H2,1H3,(H,27,29,30) RGGNBGPNKXIKCZ-UHFFFAOYSA-N 50573936 CHEMBL4866671 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 780 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573936&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164625617 471064081 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420841 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4scnc4c3)cc2oc1=O InChI=1S/C26H21N5O4S/c1-15(32)23-24(31-8-10-34-11-9-31)18-4-3-17(13-21(18)35-25(23)33)29-26-27-7-6-19(30-26)16-2-5-22-20(12-16)28-14-36-22/h2-7,12-14H,8-11H2,1H3,(H,27,29,30) LYOLNHKDMHEZFX-UHFFFAOYSA-N 50573937 CHEMBL4865492 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 322 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164623736 471064082 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420842 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4n(C)ncc4c3)cc2oc1=O InChI=1S/C27H24N6O4/c1-16(34)24-25(33-9-11-36-12-10-33)20-5-4-19(14-23(20)37-26(24)35)30-27-28-8-7-21(31-27)17-3-6-22-18(13-17)15-29-32(22)2/h3-8,13-15H,9-12H2,1-2H3,(H,28,30,31) WPONHDGVAWBDNL-UHFFFAOYSA-N 50573938 CHEMBL4874851 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 97 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164628637 471064083 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420843 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3c[nH]c4ccccc34)cc2oc1=O InChI=1S/C27H23N5O4/c1-16(33)24-25(32-10-12-35-13-11-32)19-7-6-17(14-23(19)36-26(24)34)30-27-28-9-8-22(31-27)20-15-29-21-5-3-2-4-18(20)21/h2-9,14-15,29H,10-13H2,1H3,(H,28,30,31) VXQFEQVBSBWYLC-UHFFFAOYSA-N 50573939 CHEMBL4860071 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573939&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613706 471064084 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420844 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3cn(C)c4ccccc34)cc2oc1=O InChI=1S/C28H25N5O4/c1-17(34)25-26(33-11-13-36-14-12-33)20-8-7-18(15-24(20)37-27(25)35)30-28-29-10-9-22(31-28)21-16-32(2)23-6-4-3-5-19(21)23/h3-10,15-16H,11-14H2,1-2H3,(H,29,30,31) VAOZXORJUXLWDI-UHFFFAOYSA-N 50573940 CHEMBL4853579 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 141 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164611261 471064085 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420845 CC(C)n1cc(-c2ccnc(Nc3ccc4c(N5CCOCC5)c(C(C)=O)c(=O)oc4c3)n2)c2ccccc12 InChI=1S/C30H29N5O4/c1-18(2)35-17-23(21-6-4-5-7-25(21)35)24-10-11-31-30(33-24)32-20-8-9-22-26(16-20)39-29(37)27(19(3)36)28(22)34-12-14-38-15-13-34/h4-11,16-18H,12-15H2,1-3H3,(H,31,32,33) ZLFLFYDVPNHBPQ-UHFFFAOYSA-N 50573941 CHEMBL4848505 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.5 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573941&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164617762 471064086 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420846 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-n3ccc4ccccc34)cc2oc1=O InChI=1S/C27H23N5O4/c1-17(33)24-25(31-12-14-35-15-13-31)20-7-6-19(16-22(20)36-26(24)34)29-27-28-10-8-23(30-27)32-11-9-18-4-2-3-5-21(18)32/h2-11,16H,12-15H2,1H3,(H,28,29,30) RATIBSDUFNSDEI-UHFFFAOYSA-N 50573942 CHEMBL4854509 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573942&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162515862 471064087 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420847 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-n3ccc4cccnc34)cc2oc1=O InChI=1S/C26H22N6O4/c1-16(33)22-23(31-11-13-35-14-12-31)19-5-4-18(15-20(19)36-25(22)34)29-26-28-9-6-21(30-26)32-10-7-17-3-2-8-27-24(17)32/h2-10,15H,11-14H2,1H3,(H,28,29,30) WDMXOEGVBICXPB-UHFFFAOYSA-N 50573943 CHEMBL4878189 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 214 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573943&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164627502 471064088 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420848 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-n3cnc4ccccc34)cc2oc1=O InChI=1S/C26H22N6O4/c1-16(33)23-24(31-10-12-35-13-11-31)18-7-6-17(14-21(18)36-25(23)34)29-26-27-9-8-22(30-26)32-15-28-19-4-2-3-5-20(19)32/h2-9,14-15H,10-13H2,1H3,(H,27,29,30) CXEHNXFCEBAZQX-UHFFFAOYSA-N 50573944 CHEMBL4865521 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 93 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573944&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624554 471064089 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420849 CC(C)n1nnc2ccc(cc12)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C28H27N7O4/c1-16(2)35-23-14-18(4-7-22(23)32-33-35)21-8-9-29-28(31-21)30-19-5-6-20-24(15-19)39-27(37)25(17(3)36)26(20)34-10-12-38-13-11-34/h4-9,14-16H,10-13H2,1-3H3,(H,29,30,31) HFCLVEWUMOPUHL-UHFFFAOYSA-N 50573945 CHEMBL4849841 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.5 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164610560 471064090 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420850 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)ncc1F InChI=1S/C26H22F2N4O5/c1-14(33)22-24(32-7-9-36-10-8-32)18-6-4-16(12-21(18)37-25(22)34)30-26-29-13-19(28)23(31-26)17-5-3-15(27)11-20(17)35-2/h3-6,11-13H,7-10H2,1-2H3,(H,29,30,31) RDOKVGWGKMHBMG-UHFFFAOYSA-N 50564816 CHEMBL4788347 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.6 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564816&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677629 461685154 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420851 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C30H30N6O4/c1-17(2)27-22-15-19(5-8-24(22)34-35(27)4)23-9-10-31-30(33-23)32-20-6-7-21-25(16-20)40-29(38)26(18(3)37)28(21)36-11-13-39-14-12-36/h5-10,15-17H,11-14H2,1-4H3,(H,31,32,33) RVKNONNXSNALJV-UHFFFAOYSA-N 50573929 CHEMBL4848734 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.4 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573929&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162515863 471064074 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420852 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4nn(C)cc4c3)cc2oc1=O InChI=1S/C27H24N6O4/c1-16(34)24-25(33-9-11-36-12-10-33)20-5-4-19(14-23(20)37-26(24)35)29-27-28-8-7-21(30-27)17-3-6-22-18(13-17)15-32(2)31-22/h3-8,13-15H,9-12H2,1-2H3,(H,28,29,30) RJNYFPMYDGJMLH-UHFFFAOYSA-N 50573946 CHEMBL4846827 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 52 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164609576 471064091 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420853 CC(=O)c1c(N2CCOCC2)c2ccc(Nc3nccc(n3)-c3ccc4nn(C)c(C)c4c3)cc2oc1=O InChI=1S/C28H26N6O4/c1-16-21-14-18(4-7-23(21)32-33(16)3)22-8-9-29-28(31-22)30-19-5-6-20-24(15-19)38-27(36)25(17(2)35)26(20)34-10-12-37-13-11-34/h4-9,14-15H,10-13H2,1-3H3,(H,29,30,31) JMXKUBXNZGHANG-UHFFFAOYSA-N 50573947 CHEMBL4846555 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.7 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573947&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164609503 471064092 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420854 CCc1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C29H28N6O4/c1-4-24-21-15-18(5-8-23(21)33-34(24)3)22-9-10-30-29(32-22)31-19-6-7-20-25(16-19)39-28(37)26(17(2)36)27(20)35-11-13-38-14-12-35/h5-10,15-16H,4,11-14H2,1-3H3,(H,30,31,32) JJEJNNOEHSRLAW-UHFFFAOYSA-N 50573948 CHEMBL4847535 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.5 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164617686 471064093 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420855 CCCc1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C30H30N6O4/c1-4-5-25-22-16-19(6-9-24(22)34-35(25)3)23-10-11-31-30(33-23)32-20-7-8-21-26(17-20)40-29(38)27(18(2)37)28(21)36-12-14-39-15-13-36/h6-11,16-17H,4-5,12-15H2,1-3H3,(H,31,32,33) CWZFOZMXEIEENA-UHFFFAOYSA-N 50573949 CHEMBL4859754 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.3 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573949&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164617573 471064094 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420856 CCCCc1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C31H32N6O4/c1-4-5-6-26-23-17-20(7-10-25(23)35-36(26)3)24-11-12-32-31(34-24)33-21-8-9-22-27(18-21)41-30(39)28(19(2)38)29(22)37-13-15-40-16-14-37/h7-12,17-18H,4-6,13-16H2,1-3H3,(H,32,33,34) JMJVJBLTWBOIBV-UHFFFAOYSA-N 50573950 CHEMBL4860915 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.2 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164616549 471064095 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420857 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CCOCC2)n1 InChI=1S/C27H28N8O/c1-17(2)25-21-14-18(4-7-23(21)33-34(25)3)22-8-9-28-27(32-22)31-19-5-6-20-24(15-19)29-16-30-26(20)35-10-12-36-13-11-35/h4-9,14-17H,10-13H2,1-3H3,(H,28,31,32) BNKDFJAWTSUGGL-UHFFFAOYSA-N 50573951 CHEMBL4858316 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.7 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573951&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612482 471064096 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420858 CC(C)c1[nH]nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CCCC2)n1 InChI=1S/C26H26N8/c1-16(2)24-20-13-17(5-8-22(20)32-33-24)21-9-10-27-26(31-21)30-18-6-7-19-23(14-18)28-15-29-25(19)34-11-3-4-12-34/h5-10,13-16H,3-4,11-12H2,1-2H3,(H,32,33)(H,27,30,31) IBHADHHDWIADDZ-UHFFFAOYSA-N 50573952 CHEMBL4862911 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.3 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573952&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624452 471064097 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420859 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CCNCC2)n1 InChI=1S/C27H29N9/c1-17(2)25-21-14-18(4-7-23(21)34-35(25)3)22-8-9-29-27(33-22)32-19-5-6-20-24(15-19)30-16-31-26(20)36-12-10-28-11-13-36/h4-9,14-17,28H,10-13H2,1-3H3,(H,29,32,33) FHPOPNDOFQGPBB-UHFFFAOYSA-N 50573953 CHEMBL4878634 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.5 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626682 471064098 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420860 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ccnc3c2)N2CCN(C)CC2)n1 InChI=1S/C29H32N8/c1-19(2)28-23-17-20(5-8-25(23)34-36(28)4)24-9-11-31-29(33-24)32-21-6-7-22-26(18-21)30-12-10-27(22)37-15-13-35(3)14-16-37/h5-12,17-19H,13-16H2,1-4H3,(H,31,32,33) NBSJZWFDNFWQDN-UHFFFAOYSA-N 50573930 CHEMBL4856177 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.9 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573930&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164610267 471064075 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420861 CCN1CCN(CC1)c1ncnc2cc(Nc3nccc(n3)-c3ccc4nn(C)c(C(C)C)c4c3)ccc12 InChI=1S/C29H33N9/c1-5-37-12-14-38(15-13-37)28-22-8-7-21(17-26(22)31-18-32-28)33-29-30-11-10-24(34-29)20-6-9-25-23(16-20)27(19(2)3)36(4)35-25/h6-11,16-19H,5,12-15H2,1-4H3,(H,30,33,34) GTHTUFBVEUQVRV-UHFFFAOYSA-N 50573954 CHEMBL4869627 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.1 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573954&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624258 471064099 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420862 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CCN(C)C(=O)C2)n1 InChI=1S/C28H29N9O/c1-17(2)26-21-13-18(5-8-23(21)34-36(26)4)22-9-10-29-28(33-22)32-19-6-7-20-24(14-19)30-16-31-27(20)37-12-11-35(3)25(38)15-37/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H,29,32,33) ZMTFZGPLNVXQCA-UHFFFAOYSA-N 50573955 CHEMBL4865254 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.1 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573955&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624549 471064100 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420863 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CCCNCC2)n1 InChI=1S/C28H31N9/c1-18(2)26-22-15-19(5-8-24(22)35-36(26)3)23-9-11-30-28(34-23)33-20-6-7-21-25(16-20)31-17-32-27(21)37-13-4-10-29-12-14-37/h5-9,11,15-18,29H,4,10,12-14H2,1-3H3,(H,30,33,34) UQTQEXQMIZMPDV-UHFFFAOYSA-N 50573956 CHEMBL4847800 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.7 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573956&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164617710 471064101 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420864 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CCCN(C)CC2)n1 InChI=1S/C29H33N9/c1-19(2)27-23-16-20(6-9-25(23)35-37(27)4)24-10-11-30-29(34-24)33-21-7-8-22-26(17-21)31-18-32-28(22)38-13-5-12-36(3)14-15-38/h6-11,16-19H,5,12-15H2,1-4H3,(H,30,33,34) AQLRQVRNKVAOOW-UHFFFAOYSA-N 50573957 CHEMBL4852462 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164610085 471064102 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420865 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ncnc3c2)N2CC3CC2CN3)n1 InChI=1S/C28H29N9/c1-16(2)26-22-10-17(4-7-24(22)35-36(26)3)23-8-9-29-28(34-23)33-18-5-6-21-25(12-18)31-15-32-27(21)37-14-19-11-20(37)13-30-19/h4-10,12,15-16,19-20,30H,11,13-14H2,1-3H3,(H,29,33,34) CAXZGOWIWTWCCF-UHFFFAOYSA-N 50573958 CHEMBL4857696 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.1 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573958&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615854 471064103 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420866 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(NC4CCN(C)CC4)ncnc3c2)n1 InChI=1S/C29H33N9/c1-18(2)27-23-15-19(5-8-25(23)36-38(27)4)24-9-12-30-29(35-24)34-21-6-7-22-26(16-21)31-17-32-28(22)33-20-10-13-37(3)14-11-20/h5-9,12,15-18,20H,10-11,13-14H2,1-4H3,(H,30,34,35)(H,31,32,33) MWYWPRFDCPIKNI-UHFFFAOYSA-N 50573959 CHEMBL4866140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.6 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573959&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164625026 471064104 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420867 COCCNc1ncnc2cc(Nc3nccc(n3)-c3ccc4nn(C)c(C(C)C)c4c3)ccc12 InChI=1S/C26H28N8O/c1-16(2)24-20-13-17(5-8-22(20)33-34(24)3)21-9-10-28-26(32-21)31-18-6-7-19-23(14-18)29-15-30-25(19)27-11-12-35-4/h5-10,13-16H,11-12H2,1-4H3,(H,27,29,30)(H,28,31,32) NLXGWLYKUXHWNP-UHFFFAOYSA-N 50573960 CHEMBL4871619 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.8 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573960&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164621588 471064105 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420868 COCCCNc1ncnc2cc(Nc3nccc(n3)-c3ccc4nn(C)c(C(C)C)c4c3)ccc12 InChI=1S/C27H30N8O/c1-17(2)25-21-14-18(6-9-23(21)34-35(25)3)22-10-12-29-27(33-22)32-19-7-8-20-24(15-19)30-16-31-26(20)28-11-5-13-36-4/h6-10,12,14-17H,5,11,13H2,1-4H3,(H,28,30,31)(H,29,32,33) KJJKRKBRHLAFOG-UHFFFAOYSA-N 50573961 CHEMBL4862948 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.8 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573961&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164625455 471064106 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420869 CNCCNc1ncnc2cc(Nc3nccc(n3)-c3ccc4nn(C)c(C(C)C)c4c3)ccc12 InChI=1S/C26H29N9/c1-16(2)24-20-13-17(5-8-22(20)34-35(24)4)21-9-10-29-26(33-21)32-18-6-7-19-23(14-18)30-15-31-25(19)28-12-11-27-3/h5-10,13-16,27H,11-12H2,1-4H3,(H,28,30,31)(H,29,32,33) RSWRXLOFPCNDID-UHFFFAOYSA-N 50573962 CHEMBL4853882 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.2 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612910 471064107 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420870 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(NCCN(C)C)ncnc3c2)n1 InChI=1S/C27H31N9/c1-17(2)25-21-14-18(6-9-23(21)34-36(25)5)22-10-11-29-27(33-22)32-19-7-8-20-24(15-19)30-16-31-26(20)28-12-13-35(3)4/h6-11,14-17H,12-13H2,1-5H3,(H,28,30,31)(H,29,32,33) DJJBKVQCCJJIJG-UHFFFAOYSA-N 50573963 CHEMBL4876233 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.2 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573963&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626189 471064108 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51420871 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.7 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430637 OCC(Nc1cncc(n1)-c1ccc2occc2c1)c1ccccc1 InChI=1S/C20H17N3O2/c24-13-18(14-4-2-1-3-5-14)23-20-12-21-11-17(22-20)15-6-7-19-16(10-15)8-9-25-19/h1-12,18,24H,13H2,(H,22,23) GZRCLUCDZDBXIH-UHFFFAOYSA-N 50578000 CHEMBL4859084 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8925 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578000&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615408 471054123 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430638 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2ccccc2)n1 50578001 CHEMBL4855785 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578001&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164609699 471054124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430639 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2ccc(F)cc2)n1 50578002 CHEMBL4874951 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 50 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578002&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164626315 471054125 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430640 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2ccc(F)c(F)c2)n1 50578003 CHEMBL4856958 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578003&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164613577 471054126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430641 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2cccc(OC(F)(F)F)c2)n1 50578004 CHEMBL4867494 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 633 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578004&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164621451 471054127 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430642 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2cccc(c2)C(F)(F)F)n1 50578005 CHEMBL4865258 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 341 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578005&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624976 471054128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430643 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2cccc(C)c2)n1 50578006 CHEMBL4866369 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 153 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578006&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164624576 471054129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430644 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2ccccc2F)n1 50578007 CHEMBL4848043 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578007&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164609961 471054130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430645 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccccc2)n1 50578008 CHEMBL4856767 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578008&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164611914 471054131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430646 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@H](CO)c2ccccc2)n1 50578009 CHEMBL4870732 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8769 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578009&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164620293 471054132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430647 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccc(F)cc2)n1 50578010 CHEMBL4860265 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578010&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164618094 471054133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430648 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccc(Cl)cc2)n1 50578011 CHEMBL4858120 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 76 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578011&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164612470 471054134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430649 COc1ccc(cc1)[C@H](CO)Nc1cncc(n1)-c1ccc2[nH]nc(C)c2c1 50578012 CHEMBL4861326 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 774 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578012&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615305 471054135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430650 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccc(F)c(F)c2)n1 50578013 CHEMBL4871323 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578013&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164619863 471054136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430651 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2cccc(F)c2)n1 50578014 CHEMBL4872952 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.2 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578014&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164619500 471054137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430652 C[C@@H](Nc1cncc(n1)-c1ccc2[nH]nc(C)c2c1)c1ccccc1 50578015 CHEMBL4852806 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 883 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578015&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164615682 471054138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430653 C[C@@H](Nc1cncc(n1)-c1ccc2[nH]nc(C)c2c1)c1ccc(F)cc1 50578016 CHEMBL4870617 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6799 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578016&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164623427 471054139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430654 Cc1n[nH]c2ncc(cc12)-c1cncc(N[C@@H](CO)c2ccccc2)n1 50578017 CHEMBL4875272 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.6 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578017&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164627904 471054140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430655 OC[C@H](Nc1cncc(n1)-c1ccc2[nH]ncc2c1)c1ccccc1 50578018 CHEMBL4862568 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578018&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164621641 471054141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430656 Cc1n[nH]c2ccc(cc12)-c1cncc(NC2CCCC(O)C2)n1 50578019 CHEMBL4863726 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 643 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578019&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164622173 471054142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430657 CC(CO)Nc1cncc(n1)-c1ccc2[nH]nc(C)c2c1 50578020 CHEMBL4863744 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 995 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578020&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164622628 471054143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430658 Cc1n[nH]c2ncc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1Cl 50578021 CHEMBL4857229 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578021&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164614171 471054144 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430659 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1Cl 50578022 CHEMBL4876497 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.4 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578022&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162640599 471054145 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430660 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccc(F)cc2)cnc1Cl 50578023 CHEMBL4864763 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578023&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164623711 471054146 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51430661 COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m0/s1 XWQVQSXLXAXOPJ-ACRUOGEOSA-N 50553495 CHEMBL4786559 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553495&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 68276369 461692263 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51449536 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cn(C(C)C)c4ncccc34)nc2)CC1 InChI=1S/C27H33FN8/c1-18(2)35-12-10-34(11-13-35)16-20-7-8-24(30-14-20)32-27-31-15-23(28)25(33-27)22-17-36(19(3)4)26-21(22)6-5-9-29-26/h5-9,14-15,17-19H,10-13,16H2,1-4H3,(H,30,31,32,33) BKMZBHQCZLDPLV-UHFFFAOYSA-N 50585354 CHEMBL5084067 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2021.114024 10.7270/Q2ZC86SX 34875521 Yuan, K; Kuang, W; Chen, W; Ji, M; Min, W; Zhu, Y; Hou, Y; Wang, X; Li, J; Wang, L; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585354&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166627766 476021441 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445100 Clc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 InChI=1S/C17H18ClN5/c18-14-10-21-17(22-11-4-3-7-19-8-11)23-16(14)13-9-20-15-6-2-1-5-12(13)15/h1-2,5-6,9-11,19-20H,3-4,7-8H2,(H,21,22,23)/t11-/m0/s1 XWKQZYOSWGEGIH-NSHDSACASA-N 50526790 CHEMBL4555799 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526790&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155557337 440735372 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445101 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 50583916 CHEMBL4786320 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583916&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162667027 476020003 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445102 CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 50583917 CHEMBL4800180 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 430 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583917&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 150511766 476020004 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445103 CS(=O)(=O)c1cccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583918 CHEMBL4791134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583918&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 3I3 7RA5 156631275 476020005 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445104 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(ccc12)C#N 50583919 CHEMBL5083688 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 86 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583919&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166630093 476020006 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445105 CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2ccccc12)C(F)(F)F 50583920 CHEMBL4786843 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583920&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 154940270 476020007 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445106 CS(=O)(=O)c1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583921 CHEMBL4779443 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 133 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583921&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145444157 476020008 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445107 CC1(C)CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2ccccc12)C(F)(F)F 50583922 CHEMBL4786555 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 41 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583922&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 142751812 476020009 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445108 CP(C)(=O)c1cccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583923 CHEMBL4786592 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 286 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583923&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 142751836 476020010 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445109 Cc1noc(C)c1-c1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583924 CHEMBL4790490 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 138 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583924&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 139339317 476020011 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445110 CS(=O)(=O)c1c(ccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F)C#N 50583925 CHEMBL4782954 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583925&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145444136 476020012 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445111 CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(c(ccc12)C#N)S(C)(=O)=O 50583926 CHEMBL4798916 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 907 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145444094 476020013 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445112 Cl.Cc1noc(C)c1-c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583927 CHEMBL5088381 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 90 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583927&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166632650 476020014 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445113 CC1(C)CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2c(c(ccc12)C#N)P(C)(C)=O)C(F)(F)F 50583928 CHEMBL5080711 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 572 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583928&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146662734 476020015 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51445114 CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2c(c(ccc12)C#N)P(C)(C)=O)C(F)(F)F 50583929 SY-5609::SY5609::Sy 5609::Sy-5609 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1919 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583929&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146662729 476020016 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51443591 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C25H28FN9/c1-3-34(4-2)23-16-28-20-7-5-17(13-21(20)31-23)24-19(26)15-30-25(33-24)32-22-8-6-18(14-29-22)35-11-9-27-10-12-35/h5-8,13-16,27H,3-4,9-12H2,1-2H3,(H,29,30,32,33) SKOICOFQIQHEPE-UHFFFAOYSA-N 50583189 CHEMBL5079648 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 440 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583189&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 163196279 476028194 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450904 OCc1ccn(n1)-c1ccc(Nc2cc3nc(OC4CCNCC4)ccc3cn2)c(F)c1 InChI=1S/C23H23FN6O2/c24-19-11-17(30-10-7-16(14-31)29-30)2-3-20(19)27-22-12-21-15(13-26-22)1-4-23(28-21)32-18-5-8-25-9-6-18/h1-4,7,10-13,18,25,31H,5-6,8-9,14H2,(H,26,27) DSHAIQLEQCKJIR-UHFFFAOYSA-N 50585749 CHEMBL5088480 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1966 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585749&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 65L 7VDP,7VDU 71766886 476021836 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450905 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ccc3F)N3CCOCC3)cc2n1 InChI=1S/C26H32FN5O2/c1-26(33,19-7-9-31(2)10-8-19)24-6-3-18-17-28-25(16-22(18)29-24)30-23-15-20(4-5-21(23)27)32-11-13-34-14-12-32/h3-6,15-17,19,33H,7-14H2,1-2H3,(H,28,30)/t26-/m1/s1 LUWQTRGZKXLDSO-AREMUKBSSA-N 50585766 CHEMBL5080866 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 138 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585766&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166627311 476021853 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450906 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ccc3F)N3CCN(CC3)C(C)=O)cc2n1 InChI=1S/C28H35FN6O2/c1-19(36)34-12-14-35(15-13-34)22-5-6-23(29)25(16-22)32-27-17-24-20(18-30-27)4-7-26(31-24)28(2,37)21-8-10-33(3)11-9-21/h4-7,16-18,21,37H,8-15H2,1-3H3,(H,30,32)/t28-/m1/s1 BXQKMGAINGBZAW-MUUNZHRXSA-N 50585767 CHEMBL5079342 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 523 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585767&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166628065 476021854 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450907 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ncc3F)N3CCOCC3)cc2n1 InChI=1S/C25H31FN6O2/c1-25(33,18-5-7-31(2)8-6-18)22-4-3-17-15-27-23(13-20(17)29-22)30-21-14-24(28-16-19(21)26)32-9-11-34-12-10-32/h3-4,13-16,18,33H,5-12H2,1-2H3,(H,27,28,30)/t25-/m1/s1 KFRGPUFONMCXQI-RUZDIDTESA-N 50585771 CHEMBL5078192 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 154 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585771&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166628927 476021858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450908 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(N4CCOCC4)c(cc3F)C#N)cc2n1 InChI=1S/C27H31FN6O2/c1-27(35,20-5-7-33(2)8-6-20)25-4-3-18-17-30-26(15-22(18)31-25)32-23-14-24(19(16-29)13-21(23)28)34-9-11-36-12-10-34/h3-4,13-15,17,20,35H,5-12H2,1-2H3,(H,30,32)/t27-/m1/s1 ODDUUXAHBDCKIJ-HHHXNRCGSA-N 50585772 CHEMBL5080566 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 201 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585772&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 61U 7VDS 162640251 476021859 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450909 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ncc3F)N3CCCC3)cc2n1 InChI=1S/C25H31FN6O/c1-25(33,18-7-11-31(2)12-8-18)22-6-5-17-15-27-23(13-20(17)29-22)30-21-14-24(28-16-19(21)26)32-9-3-4-10-32/h5-6,13-16,18,33H,3-4,7-12H2,1-2H3,(H,27,28,30)/t25-/m1/s1 HUNWQLBOLVYRMW-RUZDIDTESA-N 50585775 CHEMBL5091792 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 115 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585775&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166631779 476021862 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450910 CC(C)Nc1cc(Nc2cc3nc(ccc3cn2)[C@](C)(O)C2CCN(C)CC2)c(F)cn1 InChI=1S/C24H31FN6O/c1-15(2)28-22-12-20(18(25)14-27-22)30-23-11-19-16(13-26-23)5-6-21(29-19)24(3,32)17-7-9-31(4)10-8-17/h5-6,11-15,17,32H,7-10H2,1-4H3,(H2,26,27,28,30)/t24-/m1/s1 UZQXPHDZFUAMQS-XMMPIXPASA-N 50585776 CHEMBL5080123 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1298 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585776&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166627570 476021863 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450911 CC(C)Oc1cc(Nc2cc3nc(ccc3cn2)[C@](C)(O)C2CCN(C)CC2)c(F)cn1 InChI=1S/C24H30FN5O2/c1-15(2)32-23-12-20(18(25)14-27-23)29-22-11-19-16(13-26-22)5-6-21(28-19)24(3,31)17-7-9-30(4)10-8-17/h5-6,11-15,17,31H,7-10H2,1-4H3,(H,26,27,29)/t24-/m1/s1 WLPDYLPFPWPYBC-XMMPIXPASA-N 50585777 CHEMBL5083778 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 450 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585777&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166630123 476021864 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450912 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(OC4CCC4)ncc3F)cc2n1 InChI=1S/C25H30FN5O2/c1-25(32,17-8-10-31(2)11-9-17)22-7-6-16-14-27-23(12-20(16)29-22)30-21-13-24(28-15-19(21)26)33-18-4-3-5-18/h6-7,12-15,17-18,32H,3-5,8-11H2,1-2H3,(H,27,28,30)/t25-/m1/s1 CLCKDDAPJRHFEN-RUZDIDTESA-N 50585778 CHEMBL5084882 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1137 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585778&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166634189 476021865 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450913 CCc1cc(Nc2cc3nc(ccc3cn2)[C@](C)(O)C2CCN(C)CC2)c(F)cn1 InChI=1S/C23H28FN5O/c1-4-17-11-20(18(24)14-25-17)28-22-12-19-15(13-26-22)5-6-21(27-19)23(2,30)16-7-9-29(3)10-8-16/h5-6,11-14,16,30H,4,7-10H2,1-3H3,(H,25,26,28)/t23-/m1/s1 QXVWBJROURLRIW-HSZRJFAPSA-N 50585779 CHEMBL5088595 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 223 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585779&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166632020 476021866 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450914 CC(C)c1cc(Nc2cc3nc(ccc3cn2)[C@](C)(O)C2CCN(C)CC2)c(F)cn1 InChI=1S/C24H30FN5O/c1-15(2)19-11-21(18(25)14-26-19)29-23-12-20-16(13-27-23)5-6-22(28-20)24(3,31)17-7-9-30(4)10-8-17/h5-6,11-15,17,31H,7-10H2,1-4H3,(H,26,27,29)/t24-/m1/s1 HRKCERYJQXATNH-XMMPIXPASA-N 50585780 CHEMBL5090019 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 221 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585780&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166632368 476021867 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450915 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ncc3F)C(F)(F)F)cc2n1 InChI=1S/C22H23F4N5O/c1-21(32,14-5-7-31(2)8-6-14)18-4-3-13-11-28-20(10-16(13)29-18)30-17-9-19(22(24,25)26)27-12-15(17)23/h3-4,9-12,14,32H,5-8H2,1-2H3,(H,27,28,30)/t21-/m1/s1 GHNYLVIESIGHDJ-OAQYLSRUSA-N 50585781 CHEMBL5084200 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 894 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585781&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162439673 476021868 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450916 CC(C)c1cc(Nc2cc3nc(ccc3cn2)[C@](C)(O)C2CCN(C)CC2)c(F)cc1C#N InChI=1S/C26H30FN5O/c1-16(2)20-12-23(21(27)11-18(20)14-28)31-25-13-22-17(15-29-25)5-6-24(30-22)26(3,33)19-7-9-32(4)10-8-19/h5-6,11-13,15-16,19,33H,7-10H2,1-4H3,(H,29,31)/t26-/m1/s1 MOXBYMQBYZTOJA-AREMUKBSSA-N 50585782 CHEMBL5080361 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585782&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166629073 476021869 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450917 CC(C)Oc1cc(Nc2cc3nc(ccc3cn2)[C@](C)(O)C2CCN(C)CC2)c(F)cc1C#N InChI=1S/C26H30FN5O2/c1-16(2)34-23-12-22(20(27)11-18(23)14-28)31-25-13-21-17(15-29-25)5-6-24(30-21)26(3,33)19-7-9-32(4)10-8-19/h5-6,11-13,15-16,19,33H,7-10H2,1-4H3,(H,29,31)/t26-/m1/s1 QRPJDQZOXSLSEK-AREMUKBSSA-N 50585783 CHEMBL5070707 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 239 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585783&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166625236 476021870 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450918 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(c(cc3F)C#N)C(F)(F)F)cc2n1 InChI=1S/C24H23F4N5O/c1-23(34,16-5-7-33(2)8-6-16)21-4-3-14-13-30-22(11-19(14)31-21)32-20-10-17(24(26,27)28)15(12-29)9-18(20)25/h3-4,9-11,13,16,34H,5-8H2,1-2H3,(H,30,32)/t23-/m1/s1 WIQLQHJLURUMAP-HSZRJFAPSA-N 50585784 CHEMBL5087911 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 280 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585784&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166632292 476021871 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450919 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(N4CC5CCC(C4)O5)c(cc3F)C#N)cc2n1 InChI=1S/C29H33FN6O2/c1-29(37,20-7-9-35(2)10-8-20)27-6-3-18-15-32-28(13-24(18)33-27)34-25-12-26(19(14-31)11-23(25)30)36-16-21-4-5-22(17-36)38-21/h3,6,11-13,15,20-22,37H,4-5,7-10,16-17H2,1-2H3,(H,32,34)/t21?,22?,29-/m1/s1 PHVGAEJTLZFYTO-UQIPPQJZSA-N 50585785 CHEMBL5077028 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 127 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585785&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166625947 476021872 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51450920 CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ncc3F)C(N)=O)cc2n1 InChI=1S/C22H25FN6O2/c1-22(31,14-5-7-29(2)8-6-14)19-4-3-13-11-26-20(10-16(13)27-19)28-17-9-18(21(24)30)25-12-15(17)23/h3-4,9-12,14,31H,5-8H2,1-2H3,(H2,24,30)(H,25,26,28)/t22-/m1/s1 DDPAPPCCQQJSAP-JOCHJYFZSA-N 50585786 CHEMBL5080813 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 353 ChEMBL 10.1021/acs.jmedchem.1c02069 10.7270/Q2CF9V08 35143203 Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Goldfinc Bio http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585786&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166629991 476021873 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51468740 COCC1CN(C1)C1CCN(CC1)c1cc(OC)c(Nc2ncc(Br)c(Nc3ccc4OCCOc4c3P(C)(C)=O)n2)cc1C InChI=1S/C32H42BrN6O5P/c1-20-14-25(28(42-3)15-26(20)38-10-8-22(9-11-38)39-17-21(18-39)19-41-2)36-32-34-16-23(33)31(37-32)35-24-6-7-27-29(44-13-12-43-27)30(24)45(4,5)40/h6-7,14-16,21-22H,8-13,17-19H2,1-5H3,(H2,34,35,36,37) LVLFSSZNAIKYCD-UHFFFAOYSA-N 50592745 CHEMBL5188373 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4085 ChEMBL 10.7270/Q2J96BC1 35810715 Guo, Y; Gao, B; Gao, P; Fang, L; Gou, S Southeast University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592745&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155431347 482603597 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467299 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C21H21Cl2N5OS/c1-27-9-11-28(12-10-27)14-7-5-13(6-8-14)25-21-26-20(24)19(30-21)18(29)17-15(22)3-2-4-16(17)23/h2-8H,9-12,24H2,1H3,(H,25,26) QDMKHRICOLBXIP-UHFFFAOYSA-N 50592040 CHEMBL1989043 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592040&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 18521941 482602892 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467300 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)Nc2c(Cl)cccc2Cl)cc1 InChI=1S/C21H22Cl2N6OS/c1-28-9-11-29(12-10-28)14-7-5-13(6-8-14)25-21-27-19(24)18(31-21)20(30)26-17-15(22)3-2-4-16(17)23/h2-8H,9-12,24H2,1H3,(H,25,27)(H,26,30) LTZPXHKJLWIAKG-UHFFFAOYSA-N 50592041 CHEMBL5192162 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592041&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168286961 482602893 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467301 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2ccccc2)cc1 InChI=1S/C21H23N5OS/c1-25-11-13-26(14-12-25)17-9-7-16(8-10-17)23-21-24-20(22)19(28-21)18(27)15-5-3-2-4-6-15/h2-10H,11-14,22H2,1H3,(H,23,24) JJPWKYIZLQQUOF-UHFFFAOYSA-N 50592042 CHEMBL5189171 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592042&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 142730834 482602894 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467302 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2ccccc2Cl)cc1 InChI=1S/C21H22ClN5OS/c1-26-10-12-27(13-11-26)15-8-6-14(7-9-15)24-21-25-20(23)19(29-21)18(28)16-4-2-3-5-17(16)22/h2-9H,10-13,23H2,1H3,(H,24,25) ICKZVMJSCGSEBO-UHFFFAOYSA-N 50592043 CHEMBL5206282 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592043&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168294889 482602895 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467303 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2ccc(Cl)cc2Cl)cc1 InChI=1S/C21H21Cl2N5OS/c1-27-8-10-28(11-9-27)15-5-3-14(4-6-15)25-21-26-20(24)19(30-21)18(29)16-7-2-13(22)12-17(16)23/h2-7,12H,8-11,24H2,1H3,(H,25,26) LDYJFQFMUDGPPS-UHFFFAOYSA-N 50592044 CHEMBL5200515 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592044&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168291321 482602896 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467304 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2ncccc2Cl)cc1 InChI=1S/C20H21ClN6OS/c1-26-9-11-27(12-10-26)14-6-4-13(5-7-14)24-20-25-19(22)18(29-20)17(28)16-15(21)3-2-8-23-16/h2-8H,9-12,22H2,1H3,(H,24,25) LWCRIIOBDJWMPP-UHFFFAOYSA-N 50592045 CHEMBL5169674 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592045&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168269359 482602897 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467305 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(F)cccc2F)cc1 InChI=1S/C21H21F2N5OS/c1-27-9-11-28(12-10-27)14-7-5-13(6-8-14)25-21-26-20(24)19(30-21)18(29)17-15(22)3-2-4-16(17)23/h2-8H,9-12,24H2,1H3,(H,25,26) VUUCDNZACXXJSO-UHFFFAOYSA-N 50592046 CHEMBL5185655 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592046&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 9867295 482602898 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467306 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(F)cccc2C(F)(F)F)cc1 InChI=1S/C22H21F4N5OS/c1-30-9-11-31(12-10-30)14-7-5-13(6-8-14)28-21-29-20(27)19(33-21)18(32)17-15(22(24,25)26)3-2-4-16(17)23/h2-8H,9-12,27H2,1H3,(H,28,29) QVZIQCVGMKXLJK-UHFFFAOYSA-N 50592047 CHEMBL5171843 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592047&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 18521917 482602899 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467307 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(C)cc(C)cc2C)cc1 InChI=1S/C24H29N5OS/c1-15-13-16(2)20(17(3)14-15)21(30)22-23(25)27-24(31-22)26-18-5-7-19(8-6-18)29-11-9-28(4)10-12-29/h5-8,13-14H,9-12,25H2,1-4H3,(H,26,27) HZPVUKVIGLCUPG-UHFFFAOYSA-N 50592063 CHEMBL5178437 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 71 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592063&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168272673 482602915 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467308 C[C@H]1CCC[C@@H](C)N1C(=O)c1sc(Nc2ccc(cc2)N2CCN(C)CC2)nc1N InChI=1S/C22H32N6OS/c1-15-5-4-6-16(2)28(15)21(29)19-20(23)25-22(30-19)24-17-7-9-18(10-8-17)27-13-11-26(3)12-14-27/h7-10,15-16H,4-6,11-14,23H2,1-3H3,(H,24,25)/t15-,16+ BKXCJIBPKAKACH-IYBDPMFKSA-N 50592048 CHEMBL5207135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592048&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168296538 482602900 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467309 CN1CCN(CC1)c1ccc(Nc2nc(Cl)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C21H19Cl3N4OS/c1-27-9-11-28(12-10-27)14-7-5-13(6-8-14)25-21-26-20(24)19(30-21)18(29)17-15(22)3-2-4-16(17)23/h2-8H,9-12H2,1H3,(H,25,26) SVYCGAZFWIFVEN-UHFFFAOYSA-N 50592064 CHEMBL5195298 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1410 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592064&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168288421 482602916 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467310 CNc1nc(Nc2ccc(cc2)N2CCN(C)CC2)sc1C(=O)c1c(Cl)cccc1Cl InChI=1S/C22H23Cl2N5OS/c1-25-21-20(19(30)18-16(23)4-3-5-17(18)24)31-22(27-21)26-14-6-8-15(9-7-14)29-12-10-28(2)11-13-29/h3-9,25H,10-13H2,1-2H3,(H,26,27) GQBMFAFMTZCQTB-UHFFFAOYSA-N 50592049 CHEMBL5173735 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592049&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168273966 482602901 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467311 CN1CCN(CC1)c1ccc(Nc2nc(NC(C)=O)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C23H23Cl2N5O2S/c1-14(31)26-22-21(20(32)19-17(24)4-3-5-18(19)25)33-23(28-22)27-15-6-8-16(9-7-15)30-12-10-29(2)11-13-30/h3-9H,10-13H2,1-2H3,(H,26,31)(H,27,28) ZQXIMAIEMUSYSB-UHFFFAOYSA-N 50592050 CHEMBL5180577 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2790 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592050&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168274717 482602902 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467312 CN1CCN(CC1)c1cccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c1 InChI=1S/C21H21Cl2N5OS/c1-27-8-10-28(11-9-27)14-5-2-4-13(12-14)25-21-26-20(24)19(30-21)18(29)17-15(22)6-3-7-16(17)23/h2-7,12H,8-11,24H2,1H3,(H,25,26) WMHURJYFLDPMEB-UHFFFAOYSA-N 50592051 CHEMBL5180851 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592051&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168272828 482602903 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467313 COc1cc(ccc1Nc1nc(N)c(s1)C(=O)c1c(Cl)cccc1Cl)N1CCN(C)CC1 InChI=1S/C22H23Cl2N5O2S/c1-28-8-10-29(11-9-28)13-6-7-16(17(12-13)31-2)26-22-27-21(25)20(32-22)19(30)18-14(23)4-3-5-15(18)24/h3-7,12H,8-11,25H2,1-2H3,(H,26,27) UISRWLSAXIOCND-UHFFFAOYSA-N 50592052 CHEMBL5199067 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 317 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592052&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 73265211 482602904 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467314 COc1cc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)ccc1N1CCN(C)CC1 InChI=1S/C22H23Cl2N5O2S/c1-28-8-10-29(11-9-28)16-7-6-13(12-17(16)31-2)26-22-27-21(25)20(32-22)19(30)18-14(23)4-3-5-15(18)24/h3-7,12H,8-11,25H2,1-2H3,(H,26,27) SJJYOUQQFZPJEG-UHFFFAOYSA-N 50592053 CHEMBL5184522 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592053&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168283767 482602905 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467315 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)c1 InChI=1S/C22H23Cl2N5OS/c1-13-12-14(29-10-8-28(2)9-11-29)6-7-17(13)26-22-27-21(25)20(31-22)19(30)18-15(23)4-3-5-16(18)24/h3-7,12H,8-11,25H2,1-2H3,(H,26,27) JDWXSDWMRKCGRC-UHFFFAOYSA-N 50592054 CHEMBL5182610 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 317 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592054&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168279783 482602906 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467316 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)nc1 InChI=1S/C20H20Cl2N6OS/c1-27-7-9-28(10-8-27)12-5-6-15(24-11-12)25-20-26-19(23)18(30-20)17(29)16-13(21)3-2-4-14(16)22/h2-6,11H,7-10,23H2,1H3,(H,24,25,26) PUWXPMFEDYRLTM-UHFFFAOYSA-N 50592055 CHEMBL5200963 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.0 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592055&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168290839 482602907 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467317 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)cn1 InChI=1S/C20H20Cl2N6OS/c1-27-7-9-28(10-8-27)15-6-5-12(11-24-15)25-20-26-19(23)18(30-20)17(29)16-13(21)3-2-4-14(16)22/h2-6,11H,7-10,23H2,1H3,(H,25,26) JWYHKDMZXSHNLA-UHFFFAOYSA-N 50592056 CHEMBL5185990 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592056&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168282239 482602908 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467318 CN1CCN(CC1)C(=O)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C22H21Cl2N5O2S/c1-28-9-11-29(12-10-28)21(31)13-5-7-14(8-6-13)26-22-27-20(25)19(32-22)18(30)17-15(23)3-2-4-16(17)24/h2-8H,9-12,25H2,1H3,(H,26,27) DQMDXHWHDMGPCC-UHFFFAOYSA-N 50592057 CHEMBL5170651 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 592 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592057&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168269277 482602909 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467319 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C21H21Cl2N5O3S2/c1-27-9-11-28(12-10-27)33(30,31)14-7-5-13(6-8-14)25-21-26-20(24)19(32-21)18(29)17-15(22)3-2-4-16(17)23/h2-8H,9-12,24H2,1H3,(H,25,26) UXEWCQUEOJJYLF-UHFFFAOYSA-N 50592058 CHEMBL5180130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592058&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168273330 482602910 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467320 CN1CCN(Cc2ccc(Nc3nc(N)c(s3)C(=O)c3c(Cl)cccc3Cl)cc2)CC1 InChI=1S/C22H23Cl2N5OS/c1-28-9-11-29(12-10-28)13-14-5-7-15(8-6-14)26-22-27-21(25)20(31-22)19(30)18-16(23)3-2-4-17(18)24/h2-8H,9-13,25H2,1H3,(H,26,27) RAFISFVOOKCYLW-UHFFFAOYSA-N 50592059 CHEMBL5175800 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592059&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168275398 482602911 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467321 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)n1 InChI=1S/C21H22Cl2N6OS/c1-12-15(6-7-16(25-12)29-10-8-28(2)9-11-29)26-21-27-20(24)19(31-21)18(30)17-13(22)4-3-5-14(17)23/h3-7H,8-11,24H2,1-2H3,(H,26,27) LHMJTCJXGOQGEX-UHFFFAOYSA-N 50592060 CHEMBL5180190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 189 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592060&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168275536 482602912 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467322 CN1CCN(CC1)c1cnc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)c1 InChI=1S/C21H22Cl2N6OS/c1-12-10-13(29-8-6-28(2)7-9-29)11-25-20(12)27-21-26-19(24)18(31-21)17(30)16-14(22)4-3-5-15(16)23/h3-5,10-11H,6-9,24H2,1-2H3,(H,25,26,27) WTDHONKZUZNMOZ-UHFFFAOYSA-N 50592062 CHEMBL5200790 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 69 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592062&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168291539 482602914 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467323 CN1CCN(CC1)c1ncc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)n1 InChI=1S/C20H21Cl2N7OS/c1-11-14(10-24-19(25-11)29-8-6-28(2)7-9-29)26-20-27-18(23)17(31-20)16(30)15-12(21)4-3-5-13(15)22/h3-5,10H,6-9,23H2,1-2H3,(H,26,27) WIZPFVWZYLEGII-UHFFFAOYSA-N 50592061 CHEMBL5208491 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 186 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592061&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168297497 482602913 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467324 Cc1nc(ccc1Nc1nc(N)c(s1)C(=O)c1c(Cl)cccc1Cl)N1CCOCC1 InChI=1S/C20H19Cl2N5O2S/c1-11-14(5-6-15(24-11)27-7-9-29-10-8-27)25-20-26-19(23)18(30-20)17(28)16-12(21)3-2-4-13(16)22/h2-6H,7-10,23H2,1H3,(H,25,26) CKZXLBVKAYSONS-UHFFFAOYSA-N 50592065 CHEMBL5190514 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 463 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592065&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168280118 482602917 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467325 Cc1nc(ccc1Nc1nc(N)c(s1)C(=O)c1c(Cl)cccc1Cl)N1CCNCC1 InChI=1S/C20H20Cl2N6OS/c1-11-14(5-6-15(25-11)28-9-7-24-8-10-28)26-20-27-19(23)18(30-20)17(29)16-12(21)3-2-4-13(16)22/h2-6,24H,7-10,23H2,1H3,(H,26,27) TWQNXXRFGMYDMQ-UHFFFAOYSA-N 50592066 CHEMBL5203750 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 177 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592066&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168293333 482602918 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467326 CC1CN(C)CCN1c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)n1 InChI=1S/C22H24Cl2N6OS/c1-12-11-29(3)9-10-30(12)17-8-7-16(13(2)26-17)27-22-28-21(25)20(32-22)19(31)18-14(23)5-4-6-15(18)24/h4-8,12H,9-11,25H2,1-3H3,(H,27,28) VPDSZVYUHWYXCW-UHFFFAOYSA-N 50592067 CHEMBL5173236 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 181 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592067&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168273481 482602919 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467327 CC(C)C1CN(CCN1C)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)n1 InChI=1S/C24H28Cl2N6OS/c1-13(2)18-12-32(11-10-31(18)4)19-9-8-17(14(3)28-19)29-24-30-23(27)22(34-24)21(33)20-15(25)6-5-7-16(20)26/h5-9,13,18H,10-12,27H2,1-4H3,(H,29,30) BAJWJQKHEVLEIH-UHFFFAOYSA-N 50592068 CHEMBL5190264 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 300 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592068&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168284033 482602920 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467328 Cc1nc(ccc1Nc1nc(N)c(s1)C(=O)c1c(Cl)cccc1Cl)N1CCC(O)CC1 InChI=1S/C21H21Cl2N5O2S/c1-11-15(5-6-16(25-11)28-9-7-12(29)8-10-28)26-21-27-20(24)19(31-21)18(30)17-13(22)3-2-4-14(17)23/h2-6,12,29H,7-10,24H2,1H3,(H,26,27) YTDAMDXDSPIYMI-UHFFFAOYSA-N 50592069 CHEMBL5177982 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 210 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592069&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168277017 482602921 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467329 CN1CCC2(CC1)CCN(CC2)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)n1 InChI=1S/C26H30Cl2N6OS/c1-16-19(6-7-20(30-16)34-14-10-26(11-15-34)8-12-33(2)13-9-26)31-25-32-24(29)23(36-25)22(35)21-17(27)4-3-5-18(21)28/h3-7H,8-15,29H2,1-2H3,(H,31,32) CHUDIJJINHPGKN-UHFFFAOYSA-N 50592070 CHEMBL5194816 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 177 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592070&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168287120 482602922 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467334 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C21H21Cl2N5OS/c1-27-9-11-28(12-10-27)14-7-5-13(6-8-14)25-21-26-20(24)19(30-21)18(29)17-15(22)3-2-4-16(17)23/h2-8H,9-12,24H2,1H3,(H,25,26) QDMKHRICOLBXIP-UHFFFAOYSA-N 50592040 CHEMBL1989043 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1340 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592040&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 18521941 482602892 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51467335 CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2c(Cl)cccc2Cl)c(C)n1 InChI=1S/C21H22Cl2N6OS/c1-12-15(6-7-16(25-12)29-10-8-28(2)9-11-29)26-21-27-20(24)19(31-21)18(30)17-13(22)4-3-5-14(17)23/h3-7H,8-11,24H2,1-2H3,(H,26,27) LHMJTCJXGOQGEX-UHFFFAOYSA-N 50592060 CHEMBL5180190 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.7270/Q2BV7MMH 35597007 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Stanford University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592060&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168275536 482602912 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51463346 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 144 ChEMBL 10.7270/Q28K7F2W 35868123 Lei, P; Zhang, J; Liao, P; Ren, C; Wang, J; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471909 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471910 Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C18H25ClN6/c1-25-16(8-11-2-3-11)14(9-22-25)17-15(19)10-21-18(24-17)23-13-6-4-12(20)5-7-13/h9-13H,2-8,20H2,1H3,(H,21,23,24)/t12-,13- RVZJFCNYSSUDCU-JOCQHMNTSA-N 50553499 CHEMBL4754493 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553499&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 126558497 461692267 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471911 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471912 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471913 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471914 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25) YZCUMZWULWOUMD-UHFFFAOYSA-N 50553483 CHEMBL4756595 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553483&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74767009 461692251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471916 CN1CC[C@@H]([C@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3/t12-,14+/m0/s1 QLUYMIVVAYRECT-GXTWGEPZSA-N 50517730 CHEMBL4435200 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50517730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50517730&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 24887371 440726312 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471925 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >0.600000 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471926 C[C@H](CO)Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Br InChI=1S/C13H16BrN5O3S/c1-8(7-20)17-12-11(14)6-16-13(19-12)18-9-2-4-10(5-3-9)23(15,21)22/h2-6,8,20H,7H2,1H3,(H2,15,21,22)(H2,16,17,18,19)/t8-/m1/s1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 50553480 CHEMBL4741442 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 3I6 4BGH 58890996 461692248 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471927 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471928 CN1CC[C@H]([C@@H](O)C1)c1c(OP(O)(O)=O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H21ClNO8P/c1-23-7-6-12(16(26)10-23)19-18(31-32(27,28)29)9-15(25)20-14(24)8-17(30-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,16,25-26H,6-7,10H2,1H3,(H2,27,28,29)/t12-,16+/m1/s1 YRNFLVUMZIRYKY-WBMJQRKESA-N 50593921 CHEMBL5175859 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593921&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168271636 482604773 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471929 CCC(CC)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H25N5/c1-3-11(4-2)14-10-16(19-13-6-5-12(17)9-13)21-15(20-14)7-8-18-21/h7-8,10-13,19H,3-6,9,17H2,1-2H3/t12-,13-/m0/s1 VYKCLMALANGCDF-STQMWFEESA-N 50593922 CHEMBL5199065 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593922&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 146502834 482604774 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471948 COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=N)=O)c2)n1 InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) ACWKGTGIJRCOOM-UHFFFAOYSA-N 168383 US9669034, 2 (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 71618220 373987116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51471949 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <4.0 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484247 CC(=O)c1c(C)c2ccc(Nc3nccc(n3)-c3cccnc3)cc2oc1=O InChI=1S/C21H16N4O3/c1-12-16-6-5-15(10-18(16)28-20(27)19(12)13(2)26)24-21-23-9-7-17(25-21)14-4-3-8-22-11-14/h3-11H,1-2H3,(H,23,24,25) QNFBTXLSIOCFSM-UHFFFAOYSA-N 50564790 CHEMBL4781627 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 184 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564790&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 155677550 461685128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484248 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3cccnc3)cc12 InChI=1S/C24H26N6O3/c1-2-30-21-13-19(27-24-26-7-5-20(28-24)17-4-3-6-25-14-17)12-18(23(21)33-16-22(30)31)15-29-8-10-32-11-9-29/h3-7,12-14H,2,8-11,15-16H2,1H3,(H,26,27,28) XCTBUXUNIXTCND-UHFFFAOYSA-N 50598058 CHEMBL5182944 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.7 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598058&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168280486 482608910 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484249 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3ccc(F)cc3OCc3ccccc3)cc12 InChI=1S/C32H32FN5O4/c1-2-38-28-18-25(16-23(31(28)42-21-30(38)39)19-37-12-14-40-15-13-37)35-32-34-11-10-27(36-32)26-9-8-24(33)17-29(26)41-20-22-6-4-3-5-7-22/h3-11,16-18H,2,12-15,19-21H2,1H3,(H,34,35,36) OFGXOCMHJNQKDT-UHFFFAOYSA-N 50598059 CHEMBL5171854 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >100 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598059&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168270495 482608911 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484250 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3cn(C)c4ccccc34)cc12 InChI=1S/C28H30N6O3/c1-3-34-25-15-20(14-19(27(25)37-18-26(34)35)16-33-10-12-36-13-11-33)30-28-29-9-8-23(31-28)22-17-32(2)24-7-5-4-6-21(22)24/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,29,30,31) PVLPRJBNVAVTFF-UHFFFAOYSA-N 50598060 CHEMBL5185880 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 39 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598060&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168283850 482608912 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484251 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3ccc4nn(C)c(C(C)C)c4c3)cc12 InChI=1S/C30H35N7O3/c1-5-37-26-16-22(14-21(29(26)40-18-27(37)38)17-36-10-12-39-13-11-36)32-30-31-9-8-24(33-30)20-6-7-25-23(15-20)28(19(2)3)35(4)34-25/h6-9,14-16,19H,5,10-13,17-18H2,1-4H3,(H,31,32,33) YQPUVDJEBYVXDE-UHFFFAOYSA-N 50598061 CHEMBL5201460 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598061&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168291388 482608913 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484252 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3ccc4nc(C)n(C(C)C)c4c3)cc12 InChI=1S/C30H35N7O3/c1-5-36-27-16-23(14-22(29(27)40-18-28(36)38)17-35-10-12-39-13-11-35)33-30-31-9-8-24(34-30)21-6-7-25-26(15-21)37(19(2)3)20(4)32-25/h6-9,14-16,19H,5,10-13,17-18H2,1-4H3,(H,31,33,34) IOQHERPFVRHLIL-UHFFFAOYSA-N 50598062 CHEMBL5194679 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598062&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168287527 482608914 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484253 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3ccc4nnn(C(C)C)c4c3)cc12 InChI=1S/C28H32N8O3/c1-4-35-25-15-21(13-20(27(25)39-17-26(35)37)16-34-9-11-38-12-10-34)30-28-29-8-7-22(31-28)19-5-6-23-24(14-19)36(18(2)3)33-32-23/h5-8,13-15,18H,4,9-12,16-17H2,1-3H3,(H,29,30,31) CZXZJRKJVDKIRZ-UHFFFAOYSA-N 50598063 CHEMBL5188358 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598063&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168280761 482608915 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484254 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3nccc(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H28FN5O4/c1-3-32-22-14-19(12-17(25(22)36-16-24(32)33)15-31-8-10-35-11-9-31)29-26-28-7-6-21(30-26)20-5-4-18(27)13-23(20)34-2/h4-7,12-14H,3,8-11,15-16H2,1-2H3,(H,28,29,30) DWJMXSDTTGHUTQ-UHFFFAOYSA-N 50598064 CHEMBL5196603 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.6 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598064&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168285941 482608916 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484255 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H27F2N5O4/c1-3-33-21-12-18(10-16(25(21)37-15-23(33)34)14-32-6-8-36-9-7-32)30-26-29-13-20(28)24(31-26)19-5-4-17(27)11-22(19)35-2/h4-5,10-13H,3,6-9,14-15H2,1-2H3,(H,29,30,31) HGTWFXKVZMIFQK-UHFFFAOYSA-N 50598065 CHEMBL5208459 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.1 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598065&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168296859 482608917 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484256 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3cc(c(F)cn3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H28F2N4O4/c1-3-33-23-12-19(10-17(27(23)37-16-26(33)34)15-32-6-8-36-9-7-32)31-25-13-21(22(29)14-30-25)20-5-4-18(28)11-24(20)35-2/h4-5,10-14H,3,6-9,15-16H2,1-2H3,(H,30,31) RUTXXKRYVSLBCD-UHFFFAOYSA-N 50598066 CHEMBL5200954 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598066&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168290616 482608918 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484257 CCN1C(=O)COc2c(CN3CCOCC3)cc(Nc3cc(c(Cl)cn3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H28ClFN4O4/c1-3-33-23-12-19(10-17(27(23)37-16-26(33)34)15-32-6-8-36-9-7-32)31-25-13-21(22(28)14-30-25)20-5-4-18(29)11-24(20)35-2/h4-5,10-14H,3,6-9,15-16H2,1-2H3,(H,30,31) FQNRQVUJLCVBJO-UHFFFAOYSA-N 50598067 CHEMBL5203771 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 80 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598067&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168293466 482608919 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484258 CCN1C(=O)COc2c(CN3CCN(C)CC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H30F2N6O3/c1-4-35-22-13-19(11-17(26(22)38-16-24(35)36)15-34-9-7-33(2)8-10-34)31-27-30-14-21(29)25(32-27)20-6-5-18(28)12-23(20)37-3/h5-6,11-14H,4,7-10,15-16H2,1-3H3,(H,30,31,32) HYEIBMFPZRXAEP-UHFFFAOYSA-N 50598068 CHEMBL5170645 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.4 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598068&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168269275 482608920 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484259 CCN1CCN(Cc2cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc3N(CC)C(=O)COc23)CC1 InChI=1S/C28H32F2N6O3/c1-4-34-8-10-35(11-9-34)16-18-12-20(14-23-27(18)39-17-25(37)36(23)5-2)32-28-31-15-22(30)26(33-28)21-7-6-19(29)13-24(21)38-3/h6-7,12-15H,4-5,8-11,16-17H2,1-3H3,(H,31,32,33) GZHOQLMULXEMDB-UHFFFAOYSA-N 50598069 CHEMBL5185426 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.4 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598069&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168282198 482608921 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484260 CCN1C(=O)COc2c(CN3CCN(CC3)C(C)C)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C29H34F2N6O3/c1-5-37-24-14-21(33-29-32-15-23(31)27(34-29)22-7-6-20(30)13-25(22)39-4)12-19(28(24)40-17-26(37)38)16-35-8-10-36(11-9-35)18(2)3/h6-7,12-15,18H,5,8-11,16-17H2,1-4H3,(H,32,33,34) FCJBTZIGPFCDBX-UHFFFAOYSA-N 50598070 CHEMBL5206405 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.4 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598070&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168297195 482608922 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484261 CCN1C(=O)COc2c(CN3CCCCC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H29F2N5O3/c1-3-34-22-13-19(11-17(26(22)37-16-24(34)35)15-33-9-5-4-6-10-33)31-27-30-14-21(29)25(32-27)20-8-7-18(28)12-23(20)36-2/h7-8,11-14H,3-6,9-10,15-16H2,1-2H3,(H,30,31,32) WOKVPTJFHFDZLP-UHFFFAOYSA-N 50598071 CHEMBL5174423 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.7 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598071&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168276877 482608923 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484262 CCN1C(=O)COc2c(CN(C)CCOC)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H29F2N5O4/c1-5-33-21-12-18(10-16(14-32(2)8-9-35-3)25(21)37-15-23(33)34)30-26-29-13-20(28)24(31-26)19-7-6-17(27)11-22(19)36-4/h6-7,10-13H,5,8-9,14-15H2,1-4H3,(H,29,30,31) MRMIZTRXAITUEN-UHFFFAOYSA-N 50598072 CHEMBL5197862 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.3 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598072&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168288572 482608924 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484263 CCN1C(=O)COc2c(CN3CCSCC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H27F2N5O3S/c1-3-33-21-12-18(10-16(25(21)36-15-23(33)34)14-32-6-8-37-9-7-32)30-26-29-13-20(28)24(31-26)19-5-4-17(27)11-22(19)35-2/h4-5,10-13H,3,6-9,14-15H2,1-2H3,(H,29,30,31) SNEZQLJYUBSJBP-UHFFFAOYSA-N 50598073 CHEMBL5200301 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.6 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598073&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168290550 482608925 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484264 CCN1C(=O)COc2c(CN(C)CCNC)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H30F2N6O3/c1-5-34-21-12-18(10-16(14-33(3)9-8-29-2)25(21)37-15-23(34)35)31-26-30-13-20(28)24(32-26)19-7-6-17(27)11-22(19)36-4/h6-7,10-13,29H,5,8-9,14-15H2,1-4H3,(H,30,31,32) COXHFPQLBUVXLI-UHFFFAOYSA-N 50598074 CHEMBL5206344 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.5 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598074&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168295865 482608926 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484265 CCN1C(=O)COc2c(CN3CCNCC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H28F2N6O3/c1-3-34-21-12-18(10-16(25(21)37-15-23(34)35)14-33-8-6-29-7-9-33)31-26-30-13-20(28)24(32-26)19-5-4-17(27)11-22(19)36-2/h4-5,10-13,29H,3,6-9,14-15H2,1-2H3,(H,30,31,32) NZJQEKXXVRBRKU-UHFFFAOYSA-N 50598075 CHEMBL5200273 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.2 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598075&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168291258 482608927 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484266 CCN1C(=O)COc2c(CN3CCS(=O)(=O)CC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C26H27F2N5O5S/c1-3-33-21-12-18(10-16(25(21)38-15-23(33)34)14-32-6-8-39(35,36)9-7-32)30-26-29-13-20(28)24(31-26)19-5-4-17(27)11-22(19)37-2/h4-5,10-13H,3,6-9,14-15H2,1-2H3,(H,29,30,31) HYUQNQCYEGRHIU-UHFFFAOYSA-N 50598076 CHEMBL5190233 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598076&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168284014 482608928 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484267 CCN1C(=O)COc2c(CN3CCC(CC3)N3CCOCC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C31H36F2N6O4/c1-3-39-26-16-22(35-31-34-17-25(33)29(36-31)24-5-4-21(32)15-27(24)41-2)14-20(30(26)43-19-28(39)40)18-37-8-6-23(7-9-37)38-10-12-42-13-11-38/h4-5,14-17,23H,3,6-13,18-19H2,1-2H3,(H,34,35,36) NACHSLSMZHMOQM-UHFFFAOYSA-N 50598077 CHEMBL5171459 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.1 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598077&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168269722 482608929 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484268 CCN1C(=O)COc2c(CN3CCN(CC3)C(C)=O)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C28H30F2N6O4/c1-4-36-23-13-20(32-28-31-14-22(30)26(33-28)21-6-5-19(29)12-24(21)39-3)11-18(27(23)40-16-25(36)38)15-34-7-9-35(10-8-34)17(2)37/h5-6,11-14H,4,7-10,15-16H2,1-3H3,(H,31,32,33) YKSDGHNGKNMUGI-UHFFFAOYSA-N 50598078 CHEMBL5207141 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.6 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598078&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168296796 482608930 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484269 CCN1C(=O)COc2c(CN3CCN(CC3)S(C)(=O)=O)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H30F2N6O5S/c1-4-35-22-13-19(31-27-30-14-21(29)25(32-27)20-6-5-18(28)12-23(20)39-2)11-17(26(22)40-16-24(35)36)15-33-7-9-34(10-8-33)41(3,37)38/h5-6,11-14H,4,7-10,15-16H2,1-3H3,(H,30,31,32) BRMDAMYZBOCCKU-UHFFFAOYSA-N 50598079 CHEMBL5201583 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.0 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598079&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168291402 482608931 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484270 CCN(CC)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2OC)cc2N(CC)C(=O)COc12 InChI=1S/C26H29F2N5O3/c1-5-32(6-2)14-16-10-18(12-21-25(16)36-15-23(34)33(21)7-3)30-26-29-13-20(28)24(31-26)19-9-8-17(27)11-22(19)35-4/h8-13H,5-7,14-15H2,1-4H3,(H,29,30,31) LNYNSZZKFBTQRV-UHFFFAOYSA-N 50598080 CHEMBL5204512 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.6 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598080&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168294477 482608932 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484271 CCN1C(=O)COc2c(CN3CCC(C3)N(C)C)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C28H32F2N6O3/c1-5-36-23-12-19(10-17(27(23)39-16-25(36)37)14-35-9-8-20(15-35)34(2)3)32-28-31-13-22(30)26(33-28)21-7-6-18(29)11-24(21)38-4/h6-7,10-13,20H,5,8-9,14-16H2,1-4H3,(H,31,32,33) YAAYHLMEILEMJC-UHFFFAOYSA-N 50598081 CHEMBL5196054 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.7 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598081&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168285888 482608933 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484272 CCN1C(=O)COc2c(CN3CCN(CC3)C3COC3)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C29H32F2N6O4/c1-3-37-24-12-20(33-29-32-13-23(31)27(34-29)22-5-4-19(30)11-25(22)39-2)10-18(28(24)41-17-26(37)38)14-35-6-8-36(9-7-35)21-15-40-16-21/h4-5,10-13,21H,3,6-9,14-17H2,1-2H3,(H,32,33,34) ADZXDTAAQTYSRZ-UHFFFAOYSA-N 50598082 CHEMBL5184215 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.6 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598082&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168278512 482608934 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484273 CCN1C(=O)COc2c(CN3CCOC[C@H]3C)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H29F2N5O4/c1-4-34-22-11-19(9-17(26(22)38-15-24(34)35)13-33-7-8-37-14-16(33)2)31-27-30-12-21(29)25(32-27)20-6-5-18(28)10-23(20)36-3/h5-6,9-12,16H,4,7-8,13-15H2,1-3H3,(H,30,31,32)/t16-/m1/s1 WMUYOUUBRWWBTA-MRXNPFEDSA-N 50598083 CHEMBL5185390 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.9 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598083&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168280645 482608935 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51484274 CCN1C(=O)COc2c(CN(C)CCN(C)C)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C27H32F2N6O3/c1-6-35-22-13-19(11-17(26(22)38-16-24(35)36)15-34(4)10-9-33(2)3)31-27-30-14-21(29)25(32-27)20-8-7-18(28)12-23(20)37-5/h7-8,11-14H,6,9-10,15-16H2,1-5H3,(H,30,31,32) QPLPUYOXFJFKJQ-UHFFFAOYSA-N 50598084 CHEMBL5186365 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.2 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598084&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168283478 482608936 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51458422 CC(C)N1CCc2cc(ccc2C1=O)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C25H28FN7O/c1-16(2)33-10-7-17-13-18(3-5-20(17)24(33)34)23-21(26)15-29-25(31-23)30-22-6-4-19(14-28-22)32-11-8-27-9-12-32/h3-6,13-16,27H,7-12H2,1-2H3,(H,28,29,30,31) UBHPJEJMHASIRC-UHFFFAOYSA-N 50588661 CHEMBL5205035 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1959 ChEMBL 10.7270/Q2B56PQD 36350721 Chen, W; Ji, M; Cheng, H; Zheng, M; Xia, F; Min, W; Yang, H; Wang, X; Wang, L; Cao, L; Yuan, K; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588661&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168297332 482599513 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51458423 Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2C(=O)NCCc2c1 InChI=1S/C22H22FN7O/c23-18-13-27-22(28-19-4-2-16(12-26-19)30-9-7-24-8-10-30)29-20(18)15-1-3-17-14(11-15)5-6-25-21(17)31/h1-4,11-13,24H,5-10H2,(H,25,31)(H,26,27,28,29) RONAHISFEVHOEE-UHFFFAOYSA-N 50588663 CHEMBL5185518 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 382 ChEMBL 10.7270/Q2B56PQD 36350721 Chen, W; Ji, M; Cheng, H; Zheng, M; Xia, F; Min, W; Yang, H; Wang, X; Wang, L; Cao, L; Yuan, K; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588663&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168284243 482599515 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51458424 CCN1CCc2cc(ccc2C1=O)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H26FN7O/c1-2-31-10-7-16-13-17(3-5-19(16)23(31)33)22-20(25)15-28-24(30-22)29-21-6-4-18(14-27-21)32-11-8-26-9-12-32/h3-6,13-15,26H,2,7-12H2,1H3,(H,27,28,29,30) CXRFVRQTMSLWOK-UHFFFAOYSA-N 50588664 CHEMBL5170480 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2664 ChEMBL 10.7270/Q2B56PQD 36350721 Chen, W; Ji, M; Cheng, H; Zheng, M; Xia, F; Min, W; Yang, H; Wang, X; Wang, L; Cao, L; Yuan, K; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588664&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 166176929 482599516 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51458425 CN1CCc2cc(ccc2C1=O)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C23H24FN7O/c1-30-9-6-15-12-16(2-4-18(15)22(30)32)21-19(24)14-27-23(29-21)28-20-5-3-17(13-26-20)31-10-7-25-8-11-31/h2-5,12-14,25H,6-11H2,1H3,(H,26,27,28,29) RBMBLJOYIGVBNO-UHFFFAOYSA-N 50588665 CHEMBL5171767 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1038 ChEMBL 10.7270/Q2B56PQD 36350721 Chen, W; Ji, M; Cheng, H; Zheng, M; Xia, F; Min, W; Yang, H; Wang, X; Wang, L; Cao, L; Yuan, K; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588665&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168270451 482599517 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275140 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US11643416, Compound 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.40 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275145 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.50 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275150 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275155 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275160 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275165 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m0/s1 FKAJEPVSQITQLJ-INIZCTEOSA-N 601938 (R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275170 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26)/t13-/m0/s1 ZJKDYTFNXUBLEQ-ZDUSSCGKSA-N 601939 (S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275175 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275180 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m1/s1 FKAJEPVSQITQLJ-MRXNPFEDSA-N 601941 (S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275185 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275190 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275195 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275200 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275205 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 199 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275210 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275215 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275220 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 318 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275225 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275230 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482384 CC(O)CSc1nc(NCc2ccc(cc2)-n2cccn2)c2n[nH]c(C(C)C)c2n1 50597407 CHEMBL5191136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168289812 482608259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482385 CC(C)c1n[nH]c2c(NCc3ccc(cc3)-n3ccnc3)nc(SCCN)nc12 InChI=1S/C20H24N8S/c1-13(2)16-17-18(27-26-16)19(25-20(24-17)29-10-7-21)23-11-14-3-5-15(6-4-14)28-9-8-22-12-28/h3-6,8-9,12-13H,7,10-11,21H2,1-2H3,(H,26,27)(H,23,24,25) WBTZHHCDIMUWMI-UHFFFAOYSA-N 50597419 CHEMBL5182767 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597419&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168279791 482608271 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482386 CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3cnccn3)nc(SCCN)nc12 InChI=1S/C21H24N8S/c1-13(2)17-18-19(29-28-17)20(27-21(26-18)30-10-7-22)25-11-14-3-5-15(6-4-14)16-12-23-8-9-24-16/h3-6,8-9,12-13H,7,10-11,22H2,1-2H3,(H,28,29)(H,25,26,27) ORQQCLLJNPKLIL-UHFFFAOYSA-N 50597424 CHEMBL5187378 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597424&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168279648 482608276 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482387 NCCSc1nc(NCc2ccc(cc2)-n2cccn2)c2[nH]nc(C3CCC3)c2n1 InChI=1S/C21H24N8S/c22-9-12-30-21-25-18-17(15-3-1-4-15)27-28-19(18)20(26-21)23-13-14-5-7-16(8-6-14)29-11-2-10-24-29/h2,5-8,10-11,15H,1,3-4,9,12-13,22H2,(H,27,28)(H,23,25,26) MJACTWDJXKRKAV-UHFFFAOYSA-N 50597425 CHEMBL5194202 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597425&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search D5P 164513408 482608277 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482388 NCCSc1nc(NCc2ccc(cc2)-c2ccccn2)c2[nH]nc(C3CCC3)c2n1 InChI=1S/C23H25N7S/c24-11-13-31-23-27-20-19(17-4-3-5-17)29-30-21(20)22(28-23)26-14-15-7-9-16(10-8-15)18-6-1-2-12-25-18/h1-2,6-10,12,17H,3-5,11,13-14,24H2,(H,29,30)(H,26,27,28) NISFDVKKOILICU-UHFFFAOYSA-N 50597426 CHEMBL5169449 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168271003 482608278 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482389 NCCSc1nc(NCc2ccc(cc2)-c2ccccn2)c2[nH]nc(C3CCCC3)c2n1 InChI=1S/C24H27N7S/c25-12-14-32-24-28-21-20(18-5-1-2-6-18)30-31-22(21)23(29-24)27-15-16-8-10-17(11-9-16)19-7-3-4-13-26-19/h3-4,7-11,13,18H,1-2,5-6,12,14-15,25H2,(H,30,31)(H,27,28,29) JXVLTDGQDFESCZ-UHFFFAOYSA-N 50597428 CHEMBL5194833 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597428&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168287552 482608280 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51482390 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.0 ChEMBL 10.7270/Q26114CS 35749742 Jorda, R; Havlíček, L; Peřina, M; Vojáčková, V; Pospíšil, T; Djukic, S; Škerlová, J; Grúz, J; Renešová, N; Klener, P; Řezáčová, P; Strnad, M; Kryštof, V Palack£ University Olomouc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275235 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US11643416, Compound 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275240 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275245 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275250 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 398 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275255 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 118 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275260 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275265 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US11643416, Compound 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 284 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275270 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275275 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 653 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275280 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275285 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US11643416, Compound 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1275290 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US11643416, Compound 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 183 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262459 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1 XWQVQSXLXAXOPJ-NJDAHSKKSA-N 126500 US11591322, Compound NVP-2::US8778951, 310 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.75 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126500&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 66937006 225152858 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262460 C[C@H](COCc1nn[nH]n1)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 595553 US11591322, Compound 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048919 479273481 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262461 C[C@@H](COCc1nn[nH]n1)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 595554 4-(((2′-(((1R,4R)-4-(((R)-1-((2H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-5′-chloro-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (Compound 2) and 4-(((2′-(((1S,4R)-4-(((S)-1-((2H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-5′-chloro-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile ::US11591322, Compound 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595554&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049035 479273482 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262462 CCOC(=O)COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C30H41ClN6O4/c1-3-41-29(38)18-40-17-21(2)35-22-7-9-23(10-8-22)36-28-15-24(25(31)16-33-28)26-5-4-6-27(37-26)34-20-30(19-32)11-13-39-14-12-30/h4-6,15-16,21-23,35H,3,7-14,17-18,20H2,1-2H3,(H,33,36)(H,34,37)/t21-,22-,23-/m1/s1 XCSVIDXCMWZYMI-DNVJHFABSA-N 595555 US11591322, Compound 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595555&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048918 479273483 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262463 CCOC(=O)COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C30H41ClN6O4/c1-3-41-29(38)18-40-17-21(2)35-22-7-9-23(10-8-22)36-28-15-24(25(31)16-33-28)26-5-4-6-27(37-26)34-20-30(19-32)11-13-39-14-12-30/h4-6,15-16,21-23,35H,3,7-14,17-18,20H2,1-2H3,(H,33,36)(H,34,37)/t21-,22-,23-/m0/s1 XCSVIDXCMWZYMI-VABKMULXSA-N 595556 US11591322, Compound 6::ethyl 2-((R)-2-(((1R,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4]-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetate (Compound 5) and ethyl 2-((S)-2-(((1R,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4]-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048900 479273484 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262464 C[C@H](COCC(O)=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C28H37ClN6O4/c1-19(15-39-16-27(36)37)33-20-5-7-21(8-6-20)34-26-13-22(23(29)14-31-26)24-3-2-4-25(35-24)32-18-28(17-30)9-11-38-12-10-28/h2-4,13-14,19-21,33H,5-12,15-16,18H2,1H3,(H,31,34)(H,32,35)(H,36,37)/t19-,20-,21-/m1/s1 XTPCYXQQIXNDST-NJDAHSKKSA-N 595557 US11591322, Compound 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.75 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595557&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049072 479273485 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262465 C[C@@H](COCC(O)=O)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C28H37ClN6O4/c1-19(15-39-16-27(36)37)33-20-5-7-21(8-6-20)34-26-13-22(23(29)14-31-26)24-3-2-4-25(35-24)32-18-28(17-30)9-11-38-12-10-28/h2-4,13-14,19-21,33H,5-12,15-16,18H2,1H3,(H,31,34)(H,32,35)(H,36,37)/t19-,20-,21-/m0/s1 XTPCYXQQIXNDST-ACRUOGEOSA-N 595558 2-((R)-2-(((1R,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetic acid (Compound 8) and 2-((S)-2-(((1R,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetic acid ::US11591322, Compound 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049110 479273486 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262466 C[C@H](Cc1nnn[nH]1)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 595559 US11591322, Compound 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049109 479273487 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262467 C[C@@H](Cc1nnn[nH]1)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 595560 4-(((2′-(((1R,4R)-4-(((R)-1-(1H-tetrazol-5-yl)propan-2-yl)amino)cyclohexyl)amino)-5′-chloro-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (Compound 12) and 4-(((2′-(((1S,4R)-4-(((S)-1-(1H-tetrazol-5-yl)propan-2-yl)amino)cyclohexyl)amino)-5′-chloro-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile ::US11591322, Compound 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048955 479273488 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262468 CC(C)OC(=O)COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C31H43ClN6O4/c1-21(2)42-30(39)18-41-17-22(3)36-23-7-9-24(10-8-23)37-29-15-25(26(32)16-34-29)27-5-4-6-28(38-27)35-20-31(19-33)11-13-40-14-12-31/h4-6,15-16,21-24,36H,7-14,17-18,20H2,1-3H3,(H,34,37)(H,35,38)/t22-,23-,24-/m1/s1 WNONTVPKTYRAIS-WXFUMESZSA-N 595561 US11591322, Compound 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.75 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048963 479273489 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262469 CC(C)OC(=O)COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C31H43ClN6O4/c1-21(2)42-30(39)18-41-17-22(3)36-23-7-9-24(10-8-23)37-29-15-25(26(32)16-34-29)27-5-4-6-28(38-27)35-20-31(19-33)11-13-40-14-12-31/h4-6,15-16,21-24,36H,7-14,17-18,20H2,1-3H3,(H,34,37)(H,35,38)/t22-,23-,24-/m0/s1 WNONTVPKTYRAIS-HJOGWXRNSA-N 595562 US11591322, Compound 16::isopropyl 2-((R)-2-(((1r,4R)-4-((5′-Chloro-6-(((4-Cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetate (Compound 15) and isopropyl 2-((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049087 479273490 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262470 C[C@H](COCC(=O)OC(C)(C)C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C32H45ClN6O4/c1-22(18-42-19-30(40)43-31(2,3)4)37-23-8-10-24(11-9-23)38-29-16-25(26(33)17-35-29)27-6-5-7-28(39-27)36-21-32(20-34)12-14-41-15-13-32/h5-7,16-17,22-24,37H,8-15,18-19,21H2,1-4H3,(H,35,38)(H,36,39)/t22-,23-,24-/m1/s1 XNCHAOOIMXRRBN-WXFUMESZSA-N 595563 US11591322, Compound 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595563&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049076 479273491 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262471 C[C@@H](COCC(=O)OC(C)(C)C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C32H45ClN6O4/c1-22(18-42-19-30(40)43-31(2,3)4)37-23-8-10-24(11-9-23)38-29-16-25(26(33)17-35-29)27-6-5-7-28(39-27)36-21-32(20-34)12-14-41-15-13-32/h5-7,16-17,22-24,37H,8-15,18-19,21H2,1-4H3,(H,35,38)(H,36,39)/t22-,23-,24-/m0/s1 XNCHAOOIMXRRBN-HJOGWXRNSA-N 595564 US11591322, Compound 19::tert-butyl 2-((R)-2-(((1r,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetate (Compound 18) and tert-butyl 2-((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)acetate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.75 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595564&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049033 479273492 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262472 CCOC(=O)O[C@H](C)n1nnc(COC[C@@H](C)N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCC3(CCOCC3)C#N)n2)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-42-31(41-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23-,24-,25-/m1/s1 HQVRFXBZJOXOKH-ZGFBMJKBSA-N 595565 US11591322, Compound 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595565&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049102 479273493 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262473 CCOC(=O)O[C@H](C)n1nnc(COC[C@H](C)N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCC3(CCOCC3)C#N)n2)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-42-31(41-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23+,24-,25-/m0/s1 HQVRFXBZJOXOKH-NDBXHCKUSA-N 595566 (R)-1-(5-(((R)-2-(((1r,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-2H-tetrazol-2-yl)ethyl ethyl carbonate (Compound 21) and (R)-1-(5-(((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-2H-tetrazol-2-yl)ethyl ethyl carbonate ::US11591322, Compound 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.75 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595566&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049040 479273494 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262474 CCOC(=O)O[C@@H](C)n1nnc(COC[C@@H](C)N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCC3(CCOCC3)C#N)n2)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-42-31(41-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23+,24-,25-/m1/s1 HQVRFXBZJOXOKH-ZFFYZDHPSA-N 595567 US11591322, Compound 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595567&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049047 479273495 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262475 CCOC(=O)O[C@@H](C)n1nnc(COC[C@H](C)N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCC3(CCOCC3)C#N)n2)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-42-31(41-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23-,24-,25-/m0/s1 HQVRFXBZJOXOKH-QORCZRPOSA-N 595568 (S)-1-(5-(((R)-2-(((1r,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-2H-tetrazol-2-yl)ethyl ethyl carbonate (Compound 24) and (S)-1-(5-(((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-2H-tetrazol-2-yl)ethyl ethyl carbonate ::US11591322, Compound 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595568&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049063 479273496 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262476 CCOC(=O)O[C@H](C)n1nnnc1COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-31(41-42-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23-,24-,25-/m1/s1 ZYDWKIUKYSKYNN-ZGFBMJKBSA-N 595569 US11591322, Compound 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049157 479273497 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262477 CCOC(=O)O[C@H](C)n1nnnc1COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-31(41-42-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23+,24-,25-/m0/s1 ZYDWKIUKYSKYNN-NDBXHCKUSA-N 595570 (R)-1-(5-(((R)-2-(((1r,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-1H-tetrazol-1-yl)ethyl ethyl carbonate (Compound 27) and (R)-1-(5-(((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-1H-tetrazol-1-yl)ethyl ethyl carbonate ::US11591322, Compound 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048932 479273498 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262478 CCOC(=O)O[C@@H](C)n1nnnc1COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-31(41-42-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23+,24-,25-/m1/s1 ZYDWKIUKYSKYNN-ZFFYZDHPSA-N 595571 US11591322, Compound 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048921 479273499 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262479 CCOC(=O)O[C@@H](C)n1nnnc1COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C33H45ClN10O5/c1-4-48-32(45)49-23(3)44-31(41-42-43-44)19-47-18-22(2)38-24-8-10-25(11-9-24)39-30-16-26(27(34)17-36-30)28-6-5-7-29(40-28)37-21-33(20-35)12-14-46-15-13-33/h5-7,16-17,22-25,38H,4,8-15,18-19,21H2,1-3H3,(H,36,39)(H,37,40)/t22-,23-,24-,25-/m0/s1 ZYDWKIUKYSKYNN-QORCZRPOSA-N 595572 (S)-1-(5-(((R)-2-(((1r,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-1H-tetrazol-1-yl)ethyl ethyl carbonate (Compound 30) and (S)-1-(5-(((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-1H-tetrazol-1-yl)ethyl ethyl carbonate ::US11591322, Compound 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049123 479273500 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262480 C[C@H](COCc1nnn(C)n1)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H39ClN10O2/c1-20(16-42-17-28-37-39-40(2)38-28)34-21-6-8-22(9-7-21)35-27-14-23(24(30)15-32-27)25-4-3-5-26(36-25)33-19-29(18-31)10-12-41-13-11-29/h3-5,14-15,20-22,34H,6-13,16-17,19H2,1-2H3,(H,32,35)(H,33,36)/t20-,21-,22-/m1/s1 BGJDLKTYVVXXRM-YPAWHYETSA-N 595573 US11591322, Compound 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049100 479273501 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262481 C[C@@H](COCc1nnn(C)n1)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H39ClN10O2/c1-20(16-42-17-28-37-39-40(2)38-28)34-21-6-8-22(9-7-21)35-27-14-23(24(30)15-32-27)25-4-3-5-26(36-25)33-19-29(18-31)10-12-41-13-11-29/h3-5,14-15,20-22,34H,6-13,16-17,19H2,1-2H3,(H,32,35)(H,33,36)/t20-,21-,22-/m0/s1 BGJDLKTYVVXXRM-FKBYEOEOSA-N 595574 4-(((5′-chloro-2′-(((1R,4r)-4-(((R)-1-((2-methyl-2H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (Compound 33) and 4-(((5′-chloro-2′-(((1S,4r)-4-(((S)-1-((2-methyl-2H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile ::US11591322, Compound 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595574&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049107 479273502 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262482 C[C@H](COCc1nnnn1C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H39ClN10O2/c1-20(16-42-17-28-37-38-39-40(28)2)34-21-6-8-22(9-7-21)35-27-14-23(24(30)15-32-27)25-4-3-5-26(36-25)33-19-29(18-31)10-12-41-13-11-29/h3-5,14-15,20-22,34H,6-13,16-17,19H2,1-2H3,(H,32,35)(H,33,36)/t20-,21-,22-/m1/s1 POFPVNICPWZABV-YPAWHYETSA-N 595575 US11591322, Compound 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595575&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157048902 479273503 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262483 C[C@@H](COCc1nnnn1C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H39ClN10O2/c1-20(16-42-17-28-37-38-39-40(28)2)34-21-6-8-22(9-7-21)35-27-14-23(24(30)15-32-27)25-4-3-5-26(36-25)33-19-29(18-31)10-12-41-13-11-29/h3-5,14-15,20-22,34H,6-13,16-17,19H2,1-2H3,(H,32,35)(H,33,36)/t20-,21-,22-/m0/s1 POFPVNICPWZABV-FKBYEOEOSA-N 595576 4-(((5′-chloro-2′-(((1R,4r)-4-(((R)-1-((1-methyl-1H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (Compound 36) and 4-(((5′-chloro-2′-(((1S,4r)-4-(((S)-1-((1-methyl-1H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile ::US11591322, Compound 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <2.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595576&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049154 479273504 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262484 C[C@H](COCCNS(=O)(=O)C(F)(F)F)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H39ClF3N7O4S/c1-20(17-44-14-11-37-45(41,42)29(31,32)33)38-21-5-7-22(8-6-21)39-27-15-23(24(30)16-35-27)25-3-2-4-26(40-25)36-19-28(18-34)9-12-43-13-10-28/h2-4,15-16,20-22,37-38H,5-14,17,19H2,1H3,(H,35,39)(H,36,40)/t20-,21-,22-/m1/s1 KWDKPWGMOHUDFP-YPAWHYETSA-N 595577 N-(2-(2-(((1r,4r)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)ethyl)-1,1,1-trifluoromethanesulfonamide ::US11591322, Compound 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.75 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 165155973 479273505 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1262485 CC(COCCNS(=O)(=O)C(F)F)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C29H40ClF2N7O4S/c1-20(17-43-14-11-36-44(40,41)28(31)32)37-21-5-7-22(8-6-21)38-27-15-23(24(30)16-34-27)25-3-2-4-26(39-25)35-19-29(18-33)9-12-42-13-10-29/h2-4,15-16,20-22,28,36-37H,5-14,17,19H2,1H3,(H,34,38)(H,35,39)/t20?,21-,22- CHFQZGSXRCZRIQ-JTKSQVOZSA-N 595578 N-(2-(2-(((1r,4r)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)ethyl)-1,1-difluoromethanesulfonamide ::US11591322, Compound 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.5 US Patent 10.7270/Q2DB85S6 US11591322 Konradi, AW; Huang, C; Lee, K Algen Biotechnologies, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=595578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=595578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 157049108 479273506 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322415 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619410 US20230295130, Example T-34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428875 485226716 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322419 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619411 US20230295130, Example T-35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619411&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428876 485226717 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322423 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619412 US20230295130, Example T-36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428877 485226718 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322427 COC(=O)Nc1ccc2c(c[nH]c2c1OC)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619413 US20230295130, Example T-37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619413&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428878 485226719 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322435 CCOC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619418 US20230295130, Example T-42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619418&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428883 485226724 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322439 CCOC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2CNCC(C)(C)C2)ncc1C(F)(F)F 619419 US20230295130, Example T-43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619419&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428884 485226725 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322443 CC(C)OC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619420 US20230295130, Example T-44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428885 485226726 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322450 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(O[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619424 US20230295130, Example T-48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619424&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428889 485226730 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322457 COC(=O)Nc1ccc2c(c[nH]c2c1C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619428 US20230295130, Example T-52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619428&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428891 485226732 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322468 COC(=O)Nc1ccc2c(c[nH]c2c1-c1ccccc1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619436 US20230295130, Example T-60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619436&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428899 485226740 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322473 COCCOC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619438 US20230295130, Example T-62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619438&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428901 485226742 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322477 COC(=O)Nc1ccc2c(c[nH]c2c1S(=O)(=O)C(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619439 US20230295130, Example T-63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619439&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428902 485226743 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322481 COC(=O)Nc1ccc2c(c[nH]c2c1S(=O)(=O)C(C)C)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619440 US20230295130, Example T-64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619440&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428903 485226744 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322485 COC(=O)Nc1ccc2c(c[nH]c2c1S(=O)C(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619441 US20230295130, Example T-65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619441&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428904 485226745 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322489 COC(=O)Nc1ccc2c(c[nH]c2c1SC(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619442 US20230295130, Example T-66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619442&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428905 485226746 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322493 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@@H]2N)ncc1C(F)(F)F 619443 US20230295130, Example T-67 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619443&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428906 485226747 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322497 COC(=O)Nc1ccc2c(c[nH]c2c1-c1cnn(C)c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619444 US20230295130, Example T-68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619444&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428907 485226748 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322501 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619445 US20230295130, Example T-69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428908 485226749 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322505 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)=C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619446 US20230295130, Example T-70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428909 485226750 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322513 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1Br 619451 US20230295130, Example T-75 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619451&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428914 485226755 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322520 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619455 US20230295130, Example T-79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619455&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428918 485226759 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322524 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619456 US20230295130, Example T-80 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428919 485226760 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322528 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619457 US20230295130, Example T-81 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619457&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428920 485226761 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322532 CCOC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619458 US20230295130, Example T-82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428921 485226762 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322537 COC(=O)Nc1ccc2c(c[nH]c2c1C1COC1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619460 US20230295130, Example T-84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428923 485226764 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322541 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1Cl 619461 US20230295130, Example T-85 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619461&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428924 485226765 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322545 COC(=O)Nc1ccc2c(c[nH]c2c1CC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1Cl 619462 US20230295130, Example T-86 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428925 485226766 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322550 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1Cl 619464 US20230295130, Example T-88 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619464&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428927 485226768 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322561 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1Cl 619472 US20230295130, Example T-96 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619472&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428935 485226776 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322567 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619475 US20230295130, Example T-100 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619475&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058673 485226779 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322572 COC(=O)N(C)c1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619477 US20230295130, Example T-102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619477&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058705 485226781 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322576 COC(=O)N(C)c1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619477 US20230295130, Example T-102 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619477&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058705 485226781 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322581 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619479 US20230295130, Example T-105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619479&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428939 485226783 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322585 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC(F)(F)C1)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619480 US20230295130, Example T-106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428940 485226784 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322589 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619481 US20230295130, Example T-107 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619481&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428941 485226785 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322593 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619482 US20230295130, Example T-108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619482&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428942 485226786 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322597 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619483 US20230295130, Example T-109 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619483&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428943 485226787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322609 CCOC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619492 US20230295130, Example T-127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619492&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428950 485226796 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322613 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619493 US20230295130, Example T-128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619493&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428951 485226797 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322617 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCC(C)NC2)ncc1C(F)(F)F 619494 US20230295130, Example T-129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619494&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428952 485226798 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322621 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619495 US20230295130, Example T-130 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619495&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428953 485226799 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322625 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CC[C@H](C)NC2)ncc1C(F)(F)F 619496 US20230295130, Example T-131 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619496&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428954 485226800 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322629 COC(=O)Nc1ccc2c(c[nH]c2c1OC)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619497 US20230295130, Example T-132 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619497&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428955 485226801 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322634 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)=O)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619499 US20230295130, Example T-134 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619499&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058666 485226803 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322638 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)=O)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619500 US20230295130, Example T-135 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619500&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058721 485226804 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322642 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619501 US20230295130, Example T-136 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619501&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058684 485226805 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322646 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619502 US20230295130, Example T-137 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619502&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058688 485226806 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322650 CCOc1c(NC(=O)OC)ccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619503 US20230295130, Example T-138 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619503&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428957 485226807 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322654 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619504 US20230295130, Example T-139 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619504&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428958 485226808 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322658 COC(=O)Nc1ccc2c(c[nH]c2c1OC)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619505 US20230295130, Example T-140 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619505&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428959 485226809 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322663 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619507 US20230295130, Example T-142 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619507&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428961 485226811 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322667 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619508 US20230295130, Example T-143 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619508&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428962 485226812 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322673 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619511 US20230295130, Example T-146 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619511&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058706 485226815 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322679 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619514 US20230295130, Example T-149 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619514&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058715 485226818 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322683 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619515 US20230295130, Example T-150 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619515&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428964 485226819 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322687 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619516 US20230295130, Example T-151 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619516&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428965 485226820 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322692 CCOC(=O)Nc1ccc2c(c[nH]c2c1C(C)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619518 US20230295130, Example T-153 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619518&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058654 485226822 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322696 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619484 US20230295130, Example T-110::US20230295130, Example T-154 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619484&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058661 485226788 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322700 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619520 US20230295130, Example T-155 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619520&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058699 485226823 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322704 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619521 US20230295130, Example T-156 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619521&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428967 485226824 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322710 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619524 US20230295130, Example T-160::US20230295130, Example T-169 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619524&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058701 485226827 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322714 CCOc1c(NC(=O)OC)ccc2c(c[nH]c12)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619525 US20230295130, Example T-161 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619525&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058713 485226828 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322718 COC(=O)N(C)c1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619526 US20230295130, Example T-162 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619526&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058656 485226829 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322722 COC(=O)N(C)c1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619527 US20230295130, Example T-163 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058651 485226830 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322726 COC(=O)N(C)c1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619528 US20230295130, Example T-164 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619528&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058696 485226831 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322730 COC(=O)N(C)c1ccc2c(c[nH]c2c1OC(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619529 US20230295130, Example T-165 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619529&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058694 485226832 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322736 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619532 US20230295130, Example T-168 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058657 485226835 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322740 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619524 US20230295130, Example T-160::US20230295130, Example T-169 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619524&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169058701 485226827 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322288 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US20230312583, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 275 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322292 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619377 US20230295130, Example T-01 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619377&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162641734 485226683 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322296 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(O[C@H]2CCCNC2)ncc1C(F)(F)F 619378 US20230295130, Example T-02 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619378&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428847 485226684 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322300 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCCCC1=O 619379 US20230295130, Example T-03 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619379&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428848 485226685 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322304 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCCC1=O 619380 US20230295130, Example T-04 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619380&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428849 485226686 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322308 CN1CCC[C@@H](C1)Nc1ncc(c(n1)-c1c[nH]c2cc(ccc12)N1CCCC1=O)C(F)(F)F 619381 US20230295130, Example T-05 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619381&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428850 485226687 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322312 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCCOC1=O 619382 US20230295130, Example T-06 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619382&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428851 485226688 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322316 CC1(C)COC(Nc2ccc3c(c[nH]c3c2Br)-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)=N1 619383 US20230295130, Example T-07 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428852 485226689 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322320 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(NC(=O)C3CC3)ccc12 619384 US20230295130, Example T-08 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619384&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428853 485226690 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322324 CC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619385 US20230295130, Example T-09 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619385&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428854 485226691 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322328 CC(=O)Nc1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619386 US20230295130, Example T-10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619386&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428855 485226692 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322332 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(NC(=O)C3CC3)ccc12 619387 US20230295130, Example T-11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619387&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428856 485226693 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322336 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCOC1=O 619388 US20230295130, Example T-12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619388&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428857 485226694 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322340 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(ccc12)N1CCCC1=O 619389 US20230295130, Example T-13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619389&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428858 485226695 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322344 COC(=O)Nc1ccc2c(c[nH]c2c1P(C)(C)=O)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619390 US20230295130, Example T-14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619390&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 163907360 485226696 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322348 CC(=O)Nc1ccc2c(c[nH]c2c1P(C)(C)=O)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619391 US20230295130, Example T-15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 163980609 485226697 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322352 COC(=O)Nc1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619392 US20230295130, Example T-16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619392&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428859 485226698 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322356 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619393 US20230295130, Example T-17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428860 485226699 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322360 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCC1=O 619394 US20230295130, Example T-18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619394&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428861 485226700 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322364 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2CC3(CNC3)C2)ncc1C(F)(F)F InChI=1S/C21H20BrF3N6O2/c1-33-19(32)30-14-3-2-11-12(6-27-17(11)15(14)22)16-13(21(23,24)25)7-28-18(31-16)29-10-4-20(5-10)8-26-9-20/h2-3,6-7,10,26-27H,4-5,8-9H2,1H3,(H,30,32)(H,28,29,31) TVAJQMOTNSNWDG-UHFFFAOYSA-N 619395 US20230295130, Example T-19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619395&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428862 485226701 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322368 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@H](N)C2)ncc1C(F)(F)F 619396 US20230295130, Example T-20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619396&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428863 485226702 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322372 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@@H](N)C2)ncc1C(F)(F)F 619397 US20230295130, Example T-21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428864 485226703 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322376 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2CCC[C@H](N)C2)ncc1C(F)(F)F 619398 US20230295130, Example T-22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619398&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428865 485226704 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322380 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2CCC[C@@H](N)C2)ncc1C(F)(F)F 619399 US20230295130, Example T-23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619399&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428866 485226705 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322384 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2[C@H]3CNC[C@@H]23)ncc1C(F)(F)F 619400 US20230295130, Example T-24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619400&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428867 485226706 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322388 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2[C@H]3CNC[C@@H]23)ncc1C(F)(F)F 619401 US20230295130, Example T-25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619401&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428867 485226707 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322392 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2C3CCNC23)ncc1C(F)(F)F 619402 US20230295130, Example T-26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619402&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428868 485226708 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322396 COC(=O)Nc1ccc2c(c[nH]c2c1C#N)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619403 US20230295130, Example T-27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619403&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428869 485226709 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322400 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2CC3CNCC3C2)ncc1C(F)(F)F 619404 US20230295130, Example T-28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428870 485226710 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322404 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@@H](O)C2)ncc1C(F)(F)F 619405 US20230295130, Example T-29::US20230295130, Example T-51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619405&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428871 485226711 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1322409 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2CC3(CC(N)C3)C2)ncc1C(F)(F)F InChI=1S/C22H22BrF3N6O2/c1-34-20(33)31-15-3-2-12-13(8-28-18(12)16(15)23)17-14(22(24,25)26)9-29-19(32-17)30-11-6-21(7-11)4-10(27)5-21/h2-3,8-11,28H,4-7,27H2,1H3,(H,31,33)(H,29,30,32) JICAIOWSCOLKSA-UHFFFAOYSA-N 619407 US20230295130, Example T-31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619407&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169428873 485226713 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286017 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C25H29ClFN5O2/c1-13(2)24-19-9-16(10-21(27)23(19)31-32(24)4)18-11-22(28-12-20(18)26)30-25(34)15-6-5-7-17(8-15)29-14(3)33/h9-13,15,17H,5-8H2,1-4H3,(H,29,33)(H,28,30,34)/t15-,17+/m0/s1 FCWZPEHBEGYARS-DOTOQJQBSA-N 605522 (1S,3R)-3-acetamido-N-[5-chloro-4-(7-fluoro-3-isopropyl-2- methyl-indazol-5-yl)-2-pyridyl]cyclohexanecarboxamide::US11673893, Example 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.61 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605522&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136468 482598179 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286020 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C2(O)CC2)ncc1Cl InChI=1S/C27H31ClFN5O3/c1-14(2)24-19-10-16(11-21(29)23(19)33-34(24)3)18-12-22(30-13-20(18)28)32-25(35)15-5-4-6-17(9-15)31-26(36)27(37)7-8-27/h10-15,17,37H,4-9H2,1-3H3,(H,31,36)(H,30,32,35)/t15-,17+/m0/s1 XUDPANPGIPSBJA-DOTOQJQBSA-N 605523 (1S,3R)-N-[5-chloro-4-(7-fluoro-3-isopropyl-2-methyl- indazol-5-yl)-2-pyridyl]-3-[(1- hydroxycyclopropanecarbonyl)amino]- cyclohexanecarboxamide::US11673893, Example 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.477 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605523&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136523 482598180 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286023 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)Cc2cscn2)ncc1Cl InChI=1S/C28H30ClFN6O2S/c1-15(2)27-21-8-17(9-23(30)26(21)35-36(27)3)20-11-24(31-12-22(20)29)34-28(38)16-5-4-6-18(7-16)33-25(37)10-19-13-39-14-32-19/h8-9,11-16,18H,4-7,10H2,1-3H3,(H,33,37)(H,31,34,38)/t16-,18+/m0/s1 KUIAPCBDLHKMCV-FUHWJXTLSA-N 605525 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(2-(thiazol-4- yl)acetamido)cyclohexane- 1-carboxamide::US11673893, Example 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.699 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605525&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136574 482598182 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286026 COCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C26H31ClFN5O3/c1-14(2)25-19-9-16(10-21(28)24(19)32-33(25)3)18-11-22(29-12-20(18)27)31-26(35)15-6-5-7-17(8-15)30-23(34)13-36-4/h9-12,14-15,17H,5-8,13H2,1-4H3,(H,30,34)(H,29,31,35)/t15-,17+/m0/s1 SVGQRDCSVDIDOX-DOTOQJQBSA-N 605526 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(2- methoxyacctamido)cyclohexane-1-carboxamide::US11673893, Example 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.528 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605526&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136497 482598183 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286029 CCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C26H31ClFN5O2/c1-5-23(34)30-17-8-6-7-15(9-17)26(35)31-22-12-18(20(27)13-29-22)16-10-19-24(21(28)11-16)32-33(4)25(19)14(2)3/h10-15,17H,5-9H2,1-4H3,(H,30,34)(H,29,31,35)/t15-,17+/m0/s1 URJVQQWWUXRWLM-DOTOQJQBSA-N 605527 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-propionamido-cyclohexane-1- carboxamide::US11673893, Example 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.04 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605527&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136541 482598184 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286032 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NS(C)(=O)=O)ncc1Cl InChI=1S/C24H29ClFN5O3S/c1-13(2)23-18-9-15(10-20(26)22(18)29-31(23)3)17-11-21(27-12-19(17)25)28-24(32)14-6-5-7-16(8-14)30-35(4,33)34/h9-14,16,30H,5-8H2,1-4H3,(H,27,28,32)/t14-,16+/m0/s1 XUOBMFPQIZTUAZ-GOEBONIOSA-N 605528 (1S,3R)-N-[5-chloro-4-(7-fluoro-3-isopropyl-2-methyl- indazol-5-yl)-2-pyridyl]-3- (methanesulfonamido)cyclohexanecarboxamide::US11673893, Example 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.794 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605528&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136513 482598185 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286035 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CCOCC2)ncc1Cl InChI=1S/C28H34ClFN6O3/c1-16(2)26-21-12-18(13-23(30)25(21)34-35(26)3)20-14-24(31-15-22(20)29)33-27(37)17-5-4-6-19(11-17)32-28(38)36-7-9-39-10-8-36/h12-17,19H,4-11H2,1-3H3,(H,32,38)(H,31,33,37)/t17-,19+/m0/s1 NYQSSFSDFGEMQF-PKOBYXMFSA-N 605529 N-[(1R,3S)-3-[[5-chloro-4-(7-fluoro-3-isopropyl-2-methyl- indazol-5-yl)-2-pyridyl]carbamoyl]cyclohcxyl]morpholine-4- carboxamide::US11673893, Example 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.760 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605529&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136543 482598186 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286038 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CCN(C)CC2)ncc1Cl InChI=1S/C29H37ClFN7O2/c1-17(2)27-22-13-19(14-24(31)26(22)35-37(27)4)21-15-25(32-16-23(21)30)34-28(39)18-6-5-7-20(12-18)33-29(40)38-10-8-36(3)9-11-38/h13-18,20H,5-12H2,1-4H3,(H,33,40)(H,32,34,39)/t18-,20+/m0/s1 OKLIXNGBJODOLI-AZUAARDMSA-N 605530 N-((1R,3S)-3-((5-chloro-4-(7-fluoro-3-isopropyl-2-methyl- 2H-indazol-5-yl)pyridin-2-yl)carbamoyl)-cyclohexyl)-4- methylpiperazine-1-carboxamide::US11673893, Example 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.980 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605530&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136585 482598187 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286041 CNC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C25H30ClFN6O2/c1-13(2)23-18-9-15(10-20(27)22(18)32-33(23)4)17-11-21(29-12-19(17)26)31-24(34)14-6-5-7-16(8-14)30-25(35)28-3/h9-14,16H,5-8H2,1-4H3,(H2,28,30,35)(H,29,31,34)/t14-,16+/m0/s1 FBBATKKBOQLQKG-GOEBONIOSA-N 605531 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(3-methylureido)cyclohexane-1- carboxamide::US11673893, Example 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.416 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605531&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136558 482598188 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286044 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N(C)C)ncc1Cl InChI=1S/C26H32ClFN6O2/c1-14(2)24-19-10-16(11-21(28)23(19)32-34(24)5)18-12-22(29-13-20(18)27)31-25(35)15-7-6-8-17(9-15)30-26(36)33(3)4/h10-15,17H,6-9H2,1-5H3,(H,30,36)(H,29,31,35)/t15-,17+/m0/s1 FCDMIMACOWLETE-DOTOQJQBSA-N 605532 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(3,3- dimethylureido)cyclohexane-1-carboxamide::US11673893, Example 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.455 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605532&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136472 482598189 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286047 CCNC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C26H32ClFN6O2/c1-5-29-26(36)31-17-8-6-7-15(9-17)25(35)32-22-12-18(20(27)13-30-22)16-10-19-23(21(28)11-16)33-34(4)24(19)14(2)3/h10-15,17H,5-9H2,1-4H3,(H2,29,31,36)(H,30,32,35)/t15-,17+/m0/s1 WWNMRNZJYNHSAR-DOTOQJQBSA-N 605533 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(3-ethylureido)cyclohexane-1- carboxamide::US11673893, Example 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.498 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605533&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136576 482598190 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286050 CONC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C25H30ClFN6O3/c1-13(2)23-18-9-15(10-20(27)22(18)31-33(23)3)17-11-21(28-12-19(17)26)30-24(34)14-6-5-7-16(8-14)29-25(35)32-36-4/h9-14,16H,5-8H2,1-4H3,(H,28,30,34)(H2,29,32,35)/t14-,16+/m0/s1 VHBMYACYAMWWOX-GOEBONIOSA-N 605534 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(3-methoxyureido)cyclohexane- 1-carboxamide::US11673893, Example 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.489 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605534&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136486 482598191 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286053 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1 InChI=1S/C26H29ClFN5O2/c1-14(34)30-17-6-4-5-15(9-17)25(35)31-22-12-18(19(27)13-29-22)16-10-20(28)24-21(11-16)33-23(32-24)7-8-26(33,2)3/h10-13,15,17H,4-9H2,1-3H3,(H,30,34)(H,29,31,35)/t15-,17+/m0/s1 UQZLGOVFSDEYQJ-DOTOQJQBSA-N 605535 (1S,3R)-3-acetamido-N-[5-chloro-4-(5-fluoro-1,1-dimethyl- 2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-2- pyridyl]cyclohexanecarboxamidc::US11673893, Example 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.31 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605535&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136537 482598192 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286056 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1Cl InChI=1S/C27H28ClFN6O2/c1-27(2)8-6-23-34-25-20(29)11-16(12-21(25)35(23)27)18-13-22(31-14-19(18)28)33-26(37)15-4-3-5-17(10-15)32-24(36)7-9-30/h11-15,17H,3-8,10H2,1-2H3,(H,32,36)(H,31,33,37)/t15-,17+/m0/s1 GCZXMBAUDPVPSA-DOTOQJQBSA-N 605536 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-yl)-3-(2- cyanoacetamido)cyclohexane-1-carboxamide::US11673893, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.61 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605536&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136490 482598193 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286059 CC(O)CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1 InChI=1S/C28H33ClFN5O3/c1-15(36)9-25(37)32-18-6-4-5-16(10-18)27(38)33-23-13-19(20(29)14-31-23)17-11-21(30)26-22(12-17)35-24(34-26)7-8-28(35,2)3/h11-16,18,36H,4-10H2,1-3H3,(H,32,37)(H,31,33,38)/t15?,16-,18+/m0/s1 QIIDDOABFUKHBM-BSRYDQRCSA-N 605537 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-yl)-3-(3- hydroxybutanamido)cyclohexane-1-carboxamide::US11673893, Example 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.80 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605537&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136470 482598194 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286062 CC(=O)N[C@@H]1CC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1ccc2nc3CCC(C)(C)n3c2c1 InChI=1S/C25H28ClN5O2/c1-14(32)28-17-6-4-16(10-17)24(33)30-22-12-18(19(26)13-27-22)15-5-7-20-21(11-15)31-23(29-20)8-9-25(31,2)3/h5,7,11-13,16-17H,4,6,8-10H2,1-3H3,(H,28,32)(H,27,30,33)/t16-,17+/m0/s1 DDDXJQXLEOFIHJ-DLBZAZTESA-N 605540 (1S,3R)-3-acetamido-N-(5-chloro-4-(1,1-dimethyl-2,3- dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2- yl)cyclopentane-1-carboxamide::US11673893, Example 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.99 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605540&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136596 482598197 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286065 CCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1 InChI=1S/C27H31ClFN5O2/c1-4-24(35)31-17-7-5-6-15(10-17)26(36)32-22-13-18(19(28)14-30-22)16-11-20(29)25-21(12-16)34-23(33-25)8-9-27(34,2)3/h11-15,17H,4-10H2,1-3H3,(H,31,35)(H,30,32,36)/t15-,17+/m0/s1 VGKOYNIMZVZLAN-DOTOQJQBSA-N 605541 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7- yl)pyridin-2-yl)-3-propionamidocyclohexane-1-carboxamide::US11673893, Example 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.31 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605541&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136475 482598198 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286068 CCC(=O)N[C@@H]1CC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1ccc2nc3CCC(C)(C)n3c2c1 InChI=1S/C26H30ClN5O2/c1-4-24(33)29-17-7-5-16(11-17)25(34)31-22-13-18(19(27)14-28-22)15-6-8-20-21(12-15)32-23(30-20)9-10-26(32,2)3/h6,8,12-14,16-17H,4-5,7,9-11H2,1-3H3,(H,29,33)(H,28,31,34)/t16-,17+/m0/s1 BIKJIRVRDFVXQG-DLBZAZTESA-N 605543 (1S,3R)-N-(5-chloro-4-(1,1-dimethyl-2,3-dihydro-1H- benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-yl)-3- propionamidocyclopentane-1-carboxamide::US11673893, Example 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.09 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136473 482598200 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286071 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C2(O)CC2)ncc1Cl InChI=1S/C28H31ClFN5O3/c1-27(2)7-6-23-34-24-20(30)11-16(12-21(24)35(23)27)18-13-22(31-14-19(18)29)33-25(36)15-4-3-5-17(10-15)32-26(37)28(38)8-9-28/h11-15,17,38H,3-10H2,1-2H3,(H,32,37)(H,31,33,36)/t15-,17+/m0/s1 ZMFLCQAMPNGORA-DOTOQJQBSA-N 605544 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-yl)-3-(1- hydroxycyclopropane-1-carboxamido)cyclohexane-1- carboxamide::US11673893, Example 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.71 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605544&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136592 482598201 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286074 COCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1 InChI=1S/C27H31ClFN5O3/c1-27(2)8-7-23-33-25-20(29)10-16(11-21(25)34(23)27)18-12-22(30-13-19(18)28)32-26(36)15-5-4-6-17(9-15)31-24(35)14-37-3/h10-13,15,17H,4-9,14H2,1-3H3,(H,31,35)(H,30,32,36)/t15-,17+/m0/s1 WIDAZACOEGHADI-DOTOQJQBSA-N 605545 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-yl)-3-(2- methoxyacetamido)cyclohexane-1-carboxamide::US11673893, Example 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.98 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605545&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136582 482598202 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286077 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NS(C)(=O)=O)ncc1Cl InChI=1S/C25H29ClFN5O3S/c1-25(2)8-7-22-30-23-19(27)10-15(11-20(23)32(22)25)17-12-21(28-13-18(17)26)29-24(33)14-5-4-6-16(9-14)31-36(3,34)35/h10-14,16,31H,4-9H2,1-3H3,(H,28,29,33)/t14-,16+/m0/s1 DFPJSLJLOKWVCD-GOEBONIOSA-N 605546 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-yl)-3- (methylsulfonamido)cyclohexane-1-carboxamide::US11673893, Example 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.15 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605546&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136583 482598203 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286080 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1C InChI=1S/C25H30FN5O2/c1-14(2)31-13-28-24-21(26)9-18(10-22(24)31)20-11-23(27-12-15(20)3)30-25(33)17-6-5-7-19(8-17)29-16(4)32/h9-14,17,19H,5-8H2,1-4H3,(H,29,32)(H,27,30,33)/t17-,19+/m0/s1 YQOZIILPTSEVFV-PKOBYXMFSA-N 605549 (1S,3R)-3-acetamido-N-(4-(4-fluoro-1-isopropyl-1H- benzo[d]imidazol-6-yl)-5-methylpyridin-2-yl)cyclohexane-1- carboxamide::US11673893, Example 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.694 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605549&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136498 482598206 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286083 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1 InChI=1S/C27H32FN5O2/c1-15-14-29-23(31-26(35)17-6-5-7-19(10-17)30-16(2)34)13-20(15)18-11-21(28)25-22(12-18)33-24(32-25)8-9-27(33,3)4/h11-14,17,19H,5-10H2,1-4H3,(H,30,34)(H,29,31,35)/t17-,19+/m0/s1 IPJTWBVRFFWMHE-PKOBYXMFSA-N 605550 (1S,3R)-3-acetamido-N-(4-(5-fluoro-1,1-dimethyl-2,3- dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-5- methylpyridin-2-yl)cyclohexane-1-carboxamide::US11673893, Example 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.18 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605550&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136494 482598207 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286086 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CC[C@H](C2)NC(C)=O)ncc1C InChI=1S/C24H28FN5O2/c1-13(2)30-12-27-23-20(25)8-17(9-21(23)30)19-10-22(26-11-14(19)3)29-24(32)16-5-6-18(7-16)28-15(4)31/h8-13,16,18H,5-7H2,1-4H3,(H,28,31)(H,26,29,32)/t16-,18+/m0/s1 ZQYCLRJPFSGBEH-FUHWJXTLSA-N 605551 (1S,3R)-3-acetamido-N-(4-(4-fluoro-1-isopropyl-1H- benzo[d]imidazol-6-yl)-5-methylpyridin-2-yl)cyclopentane-1- carboxamide::US11673893, Example 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.539 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605551&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136503 482598208 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286089 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc2c(N=C(C)C22CCCC2)c(F)c1 InChI=1S/C27H30ClFN4O2/c1-15-27(8-3-4-9-27)21-11-18(12-23(29)25(21)31-15)20-13-24(30-14-22(20)28)33-26(35)17-6-5-7-19(10-17)32-16(2)34/h11-14,17,19H,3-10H2,1-2H3,(H,32,34)(H,30,33,35)/t17-,19+/m0/s1 NOBXXQPXRRDJOJ-PKOBYXMFSA-N 605552 (1S,3R)-3-acetamido-N-(5-chloro-4-(7'-fluoro-2'- methylspiro[cyclopentane-1,3'-indol]-5'-yl)pyridin-2- yl)cyclohexane-1-carboxamide::US11673893, Example 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.55 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605552&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136484 482598209 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286092 CC(C)c1snc2ccc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C24H27ClN4O2S/c1-13(2)23-19-10-15(7-8-21(19)29-32-23)18-11-22(26-12-20(18)25)28-24(31)16-5-4-6-17(9-16)27-14(3)30/h7-8,10-13,16-17H,4-6,9H2,1-3H3,(H,27,30)(H,26,28,31)/t16-,17+/m0/s1 NJJPIXGNLMGEOV-DLBZAZTESA-N 605553 (1S,3R)-3-acetamido-N-(5-chloro-4-(3- isopropylbenzo[c]isothiazol-5-yl)pyridin-2-yl)cyclohexane-1- carboxamide::US11673893, Example 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.87 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136507 482598210 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286095 CC1CCn2nc3ccc(cc3c12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C25H28ClN5O2/c1-14-8-9-31-24(14)20-11-16(6-7-22(20)30-31)19-12-23(27-13-21(19)26)29-25(33)17-4-3-5-18(10-17)28-15(2)32/h6-7,11-14,17-18H,3-5,8-10H2,1-2H3,(H,28,32)(H,27,29,33)/t14?,17-,18+/m0/s1 YSHZXZOOIFGADL-CXRLMVSZSA-N 605554 (1S,3R)-3-acetamido-N-(5-chloro-4-(1-methyl-2,3-dihydro- 1H-pyrrolo[1,2-b]indazol-8-yl)pyridin-2-yl)cyclohexane-1- carboxamide::US11673893, Example 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.8 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605554&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136489 482598211 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286098 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N(C)C)ncc1C InChI=1S/C26H33FN6O2/c1-15(2)33-14-29-24-21(27)10-18(11-22(24)33)20-12-23(28-13-16(20)3)31-25(34)17-7-6-8-19(9-17)30-26(35)32(4)5/h10-15,17,19H,6-9H2,1-5H3,(H,30,35)(H,28,31,34)/t17-,19+/m0/s1 VQDUCLMICBTOLT-PKOBYXMFSA-N 605555 US11673893, Example 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.23 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605555&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136488 482598212 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286101 CCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C26H32FN5O2/c1-5-24(33)30-19-8-6-7-17(9-19)26(34)31-23-12-20(16(4)13-28-23)18-10-21(27)25-22(11-18)32(14-29-25)15(2)3/h10-15,17,19H,5-9H2,1-4H3,(H,30,33)(H,28,31,34)/t17-,19+/m0/s1 MIXKIGRNSRMTFM-PKOBYXMFSA-N 605557 US11673893, Example 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.48 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605557&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136517 482598214 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286104 CC(C)C(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C27H34FN5O2/c1-15(2)26(34)31-20-8-6-7-18(9-20)27(35)32-24-12-21(17(5)13-29-24)19-10-22(28)25-23(11-19)33(14-30-25)16(3)4/h10-16,18,20H,6-9H2,1-5H3,(H,31,34)(H,29,32,35)/t18-,20+/m0/s1 VKFHEWRJQKNNFM-AZUAARDMSA-N 605558 US11673893, Example 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.01 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136479 482598215 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286106 COCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C26H32FN5O3/c1-15(2)32-14-29-25-21(27)9-18(10-22(25)32)20-11-23(28-12-16(20)3)31-26(34)17-6-5-7-19(8-17)30-24(33)13-35-4/h9-12,14-15,17,19H,5-8,13H2,1-4H3,(H,30,33)(H,28,31,34)/t17-,19+/m0/s1 NMHGCPUMMGKNKO-PKOBYXMFSA-N 605559 US11673893, Example 31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.29 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136519 482598216 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286108 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CN(C)C)ncc1C InChI=1S/C27H35FN6O2/c1-16(2)34-15-30-26-22(28)10-19(11-23(26)34)21-12-24(29-13-17(21)3)32-27(36)18-7-6-8-20(9-18)31-25(35)14-33(4)5/h10-13,15-16,18,20H,6-9,14H2,1-5H3,(H,31,35)(H,29,32,36)/t18-,20+/m0/s1 FMOZXIOQQZEZNP-AZUAARDMSA-N 605560 US11673893, Example 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.02 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136531 482598217 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286110 COC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C25H30FN5O3/c1-14(2)31-13-28-23-20(26)9-17(10-21(23)31)19-11-22(27-12-15(19)3)30-24(32)16-6-5-7-18(8-16)29-25(33)34-4/h9-14,16,18H,5-8H2,1-4H3,(H,29,33)(H,27,30,32)/t16-,18+/m0/s1 CPHBFPSTJMYONO-FUHWJXTLSA-N 605561 US11673893, Example 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.57 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146324 482598218 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286112 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NS(C)(=O)=O)ncc1C InChI=1S/C24H30FN5O3S/c1-14(2)30-13-27-23-20(25)9-17(10-21(23)30)19-11-22(26-12-15(19)3)28-24(31)16-6-5-7-18(8-16)29-34(4,32)33/h9-14,16,18,29H,5-8H2,1-4H3,(H,26,28,31)/t16-,18+/m0/s1 HEAXYWPCYLENAR-FUHWJXTLSA-N 605562 US11673893, Example 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.87 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136549 482598219 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286114 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C2(F)CC2)ncc1C InChI=1S/C27H31F2N5O2/c1-15(2)34-14-31-24-21(28)10-18(11-22(24)34)20-12-23(30-13-16(20)3)33-25(35)17-5-4-6-19(9-17)32-26(36)27(29)7-8-27/h10-15,17,19H,4-9H2,1-3H3,(H,32,36)(H,30,33,35)/t17-,19+/m0/s1 IKKCTHIIEQFHBF-PKOBYXMFSA-N 605563 US11673893, Example 35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.04 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605563&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136493 482598220 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286116 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C2(O)CC2)ncc1C InChI=1S/C27H32FN5O3/c1-15(2)33-14-30-24-21(28)10-18(11-22(24)33)20-12-23(29-13-16(20)3)32-25(34)17-5-4-6-19(9-17)31-26(35)27(36)7-8-27/h10-15,17,19,36H,4-9H2,1-3H3,(H,31,35)(H,29,32,34)/t17-,19+/m0/s1 PYTROLIEIDFMKB-PKOBYXMFSA-N 605564 US11673893, Example 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.37 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605564&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136572 482598221 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286118 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C2CN(C)C2)ncc1C InChI=1S/C28H35FN6O2/c1-16(2)35-15-31-26-23(29)9-19(10-24(26)35)22-11-25(30-12-17(22)3)33-27(36)18-6-5-7-21(8-18)32-28(37)20-13-34(4)14-20/h9-12,15-16,18,20-21H,5-8,13-14H2,1-4H3,(H,32,37)(H,30,33,36)/t18-,21+/m0/s1 ZCSRAPNEOQVRBC-GHTZIAJQSA-N 605565 US11673893, Example 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.19 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605565&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136600 482598222 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286120 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)[C@H]2C[C@H](O)C2)ncc1C InChI=1S/C28H34FN5O3/c1-15(2)34-14-31-26-23(29)10-18(11-24(26)34)22-12-25(30-13-16(22)3)33-27(36)17-5-4-6-20(7-17)32-28(37)19-8-21(35)9-19/h10-15,17,19-21,35H,4-9H2,1-3H3,(H,32,37)(H,30,33,36)/t17-,19-,20+,21-/m0/s1 DPLUHOORPHUMHS-WJMWBRGCSA-N 605566 US11673893, Example 38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.07 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605566&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136511 482598223 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286122 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CO)ncc1C InChI=1S/C25H30FN5O3/c1-14(2)31-13-28-24-20(26)8-17(9-21(24)31)19-10-22(27-11-15(19)3)30-25(34)16-5-4-6-18(7-16)29-23(33)12-32/h8-11,13-14,16,18,32H,4-7,12H2,1-3H3,(H,29,33)(H,27,30,34)/t16-,18+/m0/s1 JRYOXRWZTSUWMQ-FUHWJXTLSA-N 605567 US11673893, Example 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.91 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605567&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136520 482598224 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286124 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C3COC3)c2c1 InChI=1S/C25H28FN5O3/c1-14-10-27-23(30-25(33)16-4-3-5-18(6-16)29-15(2)32)9-20(14)17-7-21(26)24-22(8-17)31(13-28-24)19-11-34-12-19/h7-10,13,16,18-19H,3-6,11-12H2,1-2H3,(H,29,32)(H,27,30,33)/t16-,18+/m0/s1 AADQFNWYGPXQJS-FUHWJXTLSA-N 605568 US11673893, Example 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.4 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605568&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136527 482598225 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286126 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C3CC3)c2c1 InChI=1S/C25H28FN5O2/c1-14-12-27-23(30-25(33)16-4-3-5-18(8-16)29-15(2)32)11-20(14)17-9-21(26)24-22(10-17)31(13-28-24)19-6-7-19/h9-13,16,18-19H,3-8H2,1-2H3,(H,29,32)(H,27,30,33)/t16-,18+/m0/s1 XMDAGFVARVIRGW-FUHWJXTLSA-N 605569 US11673893, Example 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.92 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136532 482598226 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286128 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(CC3CC3)c2c1 InChI=1S/C26H30FN5O2/c1-15-12-28-24(31-26(34)18-4-3-5-20(8-18)30-16(2)33)11-21(15)19-9-22(27)25-23(10-19)32(14-29-25)13-17-6-7-17/h9-12,14,17-18,20H,3-8,13H2,1-2H3,(H,30,33)(H,28,31,34)/t18-,20+/m0/s1 VHAJTIDXIDFCMN-AZUAARDMSA-N 605570 US11673893, Example 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.49 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136526 482598227 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286130 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CC[C@H](O)C2)ncc1C InChI=1S/C28H35FN6O3/c1-16(2)35-15-31-26-23(29)10-19(11-24(26)35)22-12-25(30-13-17(22)3)33-27(37)18-5-4-6-20(9-18)32-28(38)34-8-7-21(36)14-34/h10-13,15-16,18,20-21,36H,4-9,14H2,1-3H3,(H,32,38)(H,30,33,37)/t18-,20+,21-/m0/s1 AYRYUMQKDYQBAS-TYPHKJRUSA-N 605571 US11673893, Example 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.979 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136594 482598228 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286132 CNC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C25H31FN6O2/c1-14(2)32-13-29-23-20(26)9-17(10-21(23)32)19-11-22(28-12-15(19)3)31-24(33)16-6-5-7-18(8-16)30-25(34)27-4/h9-14,16,18H,5-8H2,1-4H3,(H2,27,30,34)(H,28,31,33)/t16-,18+/m0/s1 SWKHRTIXNUHZMW-FUHWJXTLSA-N 605572 US11673893, Example 44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.984 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136516 482598229 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286134 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CCOCC2)ncc1C InChI=1S/C28H35FN6O3/c1-17(2)35-16-31-26-23(29)12-20(13-24(26)35)22-14-25(30-15-18(22)3)33-27(36)19-5-4-6-21(11-19)32-28(37)34-7-9-38-10-8-34/h12-17,19,21H,4-11H2,1-3H3,(H,32,37)(H,30,33,36)/t19-,21+/m0/s1 QCAKOASCPYIZKI-PZJWPPBQSA-N 605573 US11673893, Example 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.743 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136555 482598230 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286136 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CCN(C)CC2)ncc1C InChI=1S/C29H38FN7O2/c1-18(2)37-17-32-27-24(30)13-21(14-25(27)37)23-15-26(31-16-19(23)3)34-28(38)20-6-5-7-22(12-20)33-29(39)36-10-8-35(4)9-11-36/h13-18,20,22H,5-12H2,1-4H3,(H,33,39)(H,31,34,38)/t20-,22+/m0/s1 AWVIEXQGKHJISX-RBBKRZOGSA-N 605574 US11673893, Example 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.39 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605574&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136546 482598231 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286138 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NS(C)(=N)=O)ncc1C InChI=1S/C24H31FN6O2S/c1-14(2)31-13-28-23-20(25)9-17(10-21(23)31)19-11-22(27-12-15(19)3)29-24(32)16-6-5-7-18(8-16)30-34(4,26)33/h9-14,16,18H,5-8H2,1-4H3,(H2,26,30,33)(H,27,29,32)/t16-,18+,34?/m0/s1 CCZBGFFCFFPVJL-XJUPCJEPSA-N 605575 US11673893, Example 47 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.22 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605575&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136500 482598232 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286140 CNC(=O)[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C25H30FN5O2/c1-14(2)31-13-29-23-20(26)9-18(10-21(23)31)19-11-22(28-12-15(19)3)30-25(33)17-7-5-6-16(8-17)24(32)27-4/h9-14,16-17H,5-8H2,1-4H3,(H,27,32)(H,28,30,33)/t16-,17+/m1/s1 DYMGEGKNXGDRMG-SJORKVTESA-N 605576 US11673893, Example 48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.72 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605576&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136509 482598233 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286142 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)C2CCCC(C2)C#N)ncc1C InChI=1S/C24H26FN5O/c1-14(2)30-13-28-23-20(25)8-18(9-21(23)30)19-10-22(27-12-15(19)3)29-24(31)17-6-4-5-16(7-17)11-26/h8-10,12-14,16-17H,4-7H2,1-3H3,(H,27,29,31) ORBOVQLRZYRNDY-UHFFFAOYSA-N 605577 3-cyano-N-(4-(4-fluoro-1-isopropyl-1H-benzo[d]imidazol-6-yl)-5-methylpyridin-2-yl)cyclohexane-1-carboxamide::US11673893, Example 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 51.6 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136529 482598234 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286144 CC(n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N(C)C)ncc1C)C(F)(F)F InChI=1S/C26H30F4N6O2/c1-14-12-31-22(34-24(37)16-6-5-7-18(8-16)33-25(38)35(3)4)11-19(14)17-9-20(27)23-21(10-17)36(13-32-23)15(2)26(28,29)30/h9-13,15-16,18H,5-8H2,1-4H3,(H,33,38)(H,31,34,37)/t15?,16-,18+/m0/s1 ZGMXUKBNYJKTLV-BSRYDQRCSA-N 605578 US11673893, Example 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.30 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136525 482598235 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286146 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1ccc2nn3CCC(C)(C)c3c2c1 InChI=1S/C26H30ClN5O2/c1-15(33)29-18-6-4-5-17(11-18)25(34)30-23-13-19(21(27)14-28-23)16-7-8-22-20(12-16)24-26(2,3)9-10-32(24)31-22/h7-8,12-14,17-18H,4-6,9-11H2,1-3H3,(H,29,33)(H,28,30,34)/t17-,18+/m0/s1 IECCMARSLUQALN-ZWKOTPCHSA-N 605579 US11673893, Example 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.35 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136567 482598236 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286148 CC(CO)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C25H29ClFN5O3/c1-13(12-33)24-19-8-16(9-21(27)23(19)31-32(24)3)18-10-22(28-11-20(18)26)30-25(35)15-5-4-6-17(7-15)29-14(2)34/h8-11,13,15,17,33H,4-7,12H2,1-3H3,(H,29,34)(H,28,30,35)/t13?,15-,17+/m0/s1 WZBMGNIWAIVYPC-BOBJKBKNSA-N 605580 US11673893, Example 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.49 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136474 482598237 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286150 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(c2c1)C(C)(C)O InChI=1S/C25H29ClFN5O3/c1-13(33)29-16-7-5-6-14(8-16)24(34)30-21-11-17(19(26)12-28-21)15-9-18-22(20(27)10-15)31-32(4)23(18)25(2,3)35/h9-12,14,16,35H,5-8H2,1-4H3,(H,29,33)(H,28,30,34)/t14-,16+/m0/s1 IALMJWAVHXWMPQ-GOEBONIOSA-N 605581 US11673893, Example 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.820 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605581&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136487 482598238 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286152 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C3CC3)c2c1 InChI=1S/C25H27ClFN5O2/c1-13(33)29-17-5-3-4-15(8-17)25(34)30-22-11-18(20(26)12-28-22)16-9-19-23(21(27)10-16)31-32(2)24(19)14-6-7-14/h9-12,14-15,17H,3-8H2,1-2H3,(H,29,33)(H,28,30,34)/t15-,17+/m0/s1 IUMDSEQXNBJVCE-DOTOQJQBSA-N 605582 US11673893, Example 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.12 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136465 482598239 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286154 CC(C)c1n(C)nc2ccc(nc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C24H29ClN6O2/c1-13(2)23-22-20(30-31(23)4)9-8-19(28-22)17-11-21(26-12-18(17)25)29-24(33)15-6-5-7-16(10-15)27-14(3)32/h8-9,11-13,15-16H,5-7,10H2,1-4H3,(H,27,32)(H,26,29,33)/t15-,16+/m0/s1 MMEWHQQSISZZCB-JKSUJKDBSA-N 605584 US11673893, Example 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.56 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136544 482598241 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286156 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1C InChI=1S/C26H32FN5O2/c1-14(2)25-21-10-18(11-22(27)24(21)31-32(25)5)20-12-23(28-13-15(20)3)30-26(34)17-7-6-8-19(9-17)29-16(4)33/h10-14,17,19H,6-9H2,1-5H3,(H,29,33)(H,28,30,34)/t17-,19+/m0/s1 JMQICEYHFZDQRQ-PKOBYXMFSA-N 605585 US11673893, Example 56 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.52 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136534 482598242 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286158 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C2(F)CC2)ncc1Cl InChI=1S/C27H30ClF2N5O2/c1-14(2)24-19-10-16(11-21(29)23(19)34-35(24)3)18-12-22(31-13-20(18)28)33-25(36)15-5-4-6-17(9-15)32-26(37)27(30)7-8-27/h10-15,17H,4-9H2,1-3H3,(H,32,37)(H,31,33,36)/t15-,17+/m0/s1 ZDQGFSXRMBIKKI-DOTOQJQBSA-N 605586 US11673893, Example 57 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605586&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136586 482598243 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286160 COc1ncccc1C(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C30H32ClFN6O3/c1-16(2)27-22-12-18(13-24(32)26(22)37-38(27)3)21-14-25(34-15-23(21)31)36-28(39)17-7-5-8-19(11-17)35-29(40)20-9-6-10-33-30(20)41-4/h6,9-10,12-17,19H,5,7-8,11H2,1-4H3,(H,35,40)(H,34,36,39)/t17-,19+/m0/s1 IQNFHQLDSXSHGX-PKOBYXMFSA-N 605587 US11673893, Example 58 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.13 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136476 482598244 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286162 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)c2cc(C)on2)ncc1Cl InChI=1S/C28H30ClFN6O3/c1-14(2)26-20-10-17(11-22(30)25(20)34-36(26)4)19-12-24(31-13-21(19)29)33-27(37)16-6-5-7-18(9-16)32-28(38)23-8-15(3)39-35-23/h8,10-14,16,18H,5-7,9H2,1-4H3,(H,32,38)(H,31,33,37)/t16-,18+/m0/s1 IKRBTPMIGDQTPT-FUHWJXTLSA-N 605588 US11673893, Example 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.95 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136501 482598245 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286164 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)c2ccc(C)nc2)ncc1Cl InChI=1S/C30H32ClFN6O2/c1-16(2)28-23-11-20(12-25(32)27(23)37-38(28)4)22-13-26(34-15-24(22)31)36-29(39)18-6-5-7-21(10-18)35-30(40)19-9-8-17(3)33-14-19/h8-9,11-16,18,21H,5-7,10H2,1-4H3,(H,35,40)(H,34,36,39)/t18-,21+/m0/s1 LZTILAJWCMPABA-GHTZIAJQSA-N 605589 US11673893, Example 60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.27 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136469 482598246 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286167 COCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C27H34FN5O3/c1-15(2)26-21-10-18(11-22(28)25(21)32-33(26)4)20-12-23(29-13-16(20)3)31-27(35)17-7-6-8-19(9-17)30-24(34)14-36-5/h10-13,15,17,19H,6-9,14H2,1-5H3,(H,30,34)(H,29,31,35)/t17-,19+/m0/s1 VUKIOSRRSWOLGW-PKOBYXMFSA-N 605591 US11673893, Example 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.41 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605591&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136477 482598248 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286169 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)[C@@H]2C[C@H](O)C2)ncc1C InChI=1S/C29H36FN5O3/c1-15(2)27-23-11-18(12-24(30)26(23)34-35(27)4)22-13-25(31-14-16(22)3)33-28(37)17-6-5-7-20(8-17)32-29(38)19-9-21(36)10-19/h11-15,17,19-21,36H,5-10H2,1-4H3,(H,32,38)(H,31,33,37)/t17-,19-,20+,21+/m0/s1 BMXNNFIAYWHIGH-MJUUVYJYSA-N 605592 US11673893, Example 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.961 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605592&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146434 482598249 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286171 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)c2cc(C)on2)ncc1C InChI=1S/C29H33FN6O3/c1-15(2)27-22-11-19(12-23(30)26(22)34-36(27)5)21-13-25(31-14-16(21)3)33-28(37)18-7-6-8-20(10-18)32-29(38)24-9-17(4)39-35-24/h9,11-15,18,20H,6-8,10H2,1-5H3,(H,32,38)(H,31,33,37)/t18-,20+/m0/s1 YGXSGRGRLJSQDK-AZUAARDMSA-N 605594 US11673893, Example 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.93 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605594&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136605 482598251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286173 COc1ncccc1C(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C31H35FN6O3/c1-17(2)28-24-13-20(14-25(32)27(24)37-38(28)4)23-15-26(34-16-18(23)3)36-29(39)19-8-6-9-21(12-19)35-30(40)22-10-7-11-33-31(22)41-5/h7,10-11,13-17,19,21H,6,8-9,12H2,1-5H3,(H,35,40)(H,34,36,39)/t19-,21+/m0/s1 VVTIGHNVXLCCKY-PZJWPPBQSA-N 605595 US11673893, Example 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.95 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605595&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136578 482598252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286175 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1Cl InChI=1S/C26H28ClFN6O2/c1-14(2)25-19-10-16(11-21(28)24(19)33-34(25)3)18-12-22(30-13-20(18)27)32-26(36)15-5-4-6-17(9-15)31-23(35)7-8-29/h10-15,17H,4-7,9H2,1-3H3,(H,31,35)(H,30,32,36)/t15-,17+/m0/s1 ZKDRQTUQLALDNJ-DOTOQJQBSA-N 605596 US11673893, Example 65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.480 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605596&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136556 482598253 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286177 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1C InChI=1S/C27H31FN6O2/c1-15(2)26-21-11-18(12-22(28)25(21)33-34(26)4)20-13-23(30-14-16(20)3)32-27(36)17-6-5-7-19(10-17)31-24(35)8-9-29/h11-15,17,19H,5-8,10H2,1-4H3,(H,31,35)(H,30,32,36)/t17-,19+/m0/s1 XCGKNNRKGHJIBF-PKOBYXMFSA-N 605597 US11673893, Example 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.67 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136603 482598254 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286180 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1C InChI=1S/C27H31FN6O2/c1-15(2)26-21-11-18(12-22(28)25(21)33-34(26)4)20-13-23(30-14-16(20)3)32-27(36)17-6-5-7-19(10-17)31-24(35)8-9-29/h11-15,17,19H,5-8,10H2,1-4H3,(H,31,35)(H,30,32,36)/t17-,19+/m0/s1 XCGKNNRKGHJIBF-PKOBYXMFSA-N 605597 US11673893, Example 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.65 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605597&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136603 482598254 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286182 CCNC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(ccn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C26H33FN6O2/c1-5-28-26(35)30-19-8-6-7-17(11-19)25(34)31-22-14-16(9-10-29-22)18-12-20-23(21(27)13-18)32-33(4)24(20)15(2)3/h9-10,12-15,17,19H,5-8,11H2,1-4H3,(H2,28,30,35)(H,29,31,34)/t17-,19+/m0/s1 WDXRGXOFKKTSHX-PKOBYXMFSA-N 605598 US11673893, Example 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.29 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605598&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136593 482598255 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286185 CC(C)c1n(C)nc2c(F)cc(cc12)-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CCC2)c1 InChI=1S/C27H33FN6O2/c1-16(2)25-21-13-19(14-22(28)24(21)32-33(25)3)17-8-9-29-23(15-17)31-26(35)18-6-4-7-20(12-18)30-27(36)34-10-5-11-34/h8-9,13-16,18,20H,4-7,10-12H2,1-3H3,(H,30,36)(H,29,31,35)/t18-,20+/m0/s1 HCWVCCMKEVZHLU-AZUAARDMSA-N 605599 US11673893, Example 69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.43 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605599&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136554 482598256 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286187 COC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1 InChI=1S/C25H29ClFN5O3/c1-13(2)23-18-9-15(10-20(27)22(18)31-32(23)3)17-11-21(28-12-19(17)26)30-24(33)14-6-5-7-16(8-14)29-25(34)35-4/h9-14,16H,5-8H2,1-4H3,(H,29,34)(H,28,30,33)/t14-,16+/m0/s1 RUSDDQSVRZWWRP-GOEBONIOSA-N 605600 US11673893, Example 70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.39 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605600&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146362 482598257 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286189 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)OC2CCOCC2)ncc1Cl InChI=1S/C29H35ClFN5O4/c1-16(2)27-22-12-18(13-24(31)26(22)35-36(27)3)21-14-25(32-15-23(21)30)34-28(37)17-5-4-6-19(11-17)33-29(38)40-20-7-9-39-10-8-20/h12-17,19-20H,4-11H2,1-3H3,(H,33,38)(H,32,34,37)/t17-,19+/m0/s1 GRPNANHCWCBMEF-PKOBYXMFSA-N 605601 US11673893, Example 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.70 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605601&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146359 482598258 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286191 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)OCc2ccn(C)n2)ncc1Cl InChI=1S/C29H33ClFN7O3/c1-16(2)27-22-11-18(12-24(31)26(22)36-38(27)4)21-13-25(32-14-23(21)30)34-28(39)17-6-5-7-19(10-17)33-29(40)41-15-20-8-9-37(3)35-20/h8-9,11-14,16-17,19H,5-7,10,15H2,1-4H3,(H,33,40)(H,32,34,39)/t17-,19+/m0/s1 NWYNSLFHFPXYFP-PKOBYXMFSA-N 605602 US11673893, Example 72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.48 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605602&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146380 482598259 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286193 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)OCC2CC2(F)F)ncc1Cl InChI=1S/C28H31ClF3N5O3/c1-14(2)25-20-8-16(9-22(30)24(20)36-37(25)3)19-10-23(33-12-21(19)29)35-26(38)15-5-4-6-18(7-15)34-27(39)40-13-17-11-28(17,31)32/h8-10,12,14-15,17-18H,4-7,11,13H2,1-3H3,(H,34,39)(H,33,35,38)/t15-,17?,18+/m0/s1 GWJUJVNEBMMNHN-DKKDMOBXSA-N 605603 US11673893, Example 73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.27 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605603&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146363 482598260 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286195 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(c2c1)C(C)(O)C(F)(F)F InChI=1S/C25H26ClF4N5O3/c1-12(36)32-15-6-4-5-13(7-15)23(37)33-20-10-16(18(26)11-31-20)14-8-17-21(19(27)9-14)34-35(3)22(17)24(2,38)25(28,29)30/h8-11,13,15,38H,4-7H2,1-3H3,(H,32,36)(H,31,33,37)/t13-,15+,24?/m0/s1 OVONSEUUMQWSJD-FIEKXIGZSA-N 605604 US11673893, Example 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.938 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605604&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136570 482598261 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286197 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(c2c1)C(C)(O)C(F)F InChI=1S/C25H27ClF3N5O3/c1-12(35)31-15-6-4-5-13(7-15)23(36)32-20-10-16(18(26)11-30-20)14-8-17-21(19(27)9-14)33-34(3)22(17)25(2,37)24(28)29/h8-11,13,15,24,37H,4-7H2,1-3H3,(H,31,35)(H,30,32,36)/t13-,15+,25?/m0/s1 VQAQEQWKWBXYBD-IULYNMNVSA-N 605605 US11673893, Example 75 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.38 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605605&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136562 482598262 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286199 Cc1cnc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)cc1-c1cc(F)c2nn(C)c(c2c1)[C@@](C)(O)C(F)(F)F InChI=1S/C27H28F4N6O3/c1-14-13-33-21(35-25(39)15-5-4-6-17(9-15)34-22(38)7-8-32)12-18(14)16-10-19-23(20(28)11-16)36-37(3)24(19)26(2,40)27(29,30)31/h10-13,15,17,40H,4-7,9H2,1-3H3,(H,34,38)(H,33,35,39)/t15-,17+,26+/m0/s1 KBJYBBVTVRWYJU-IRRNSTBUSA-N 605606 US11673893, Example 76-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.780 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605606&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136481 482598263 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286201 Cc1cnc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)cc1-c1cc(F)c2nn(C)c(c2c1)[C@](C)(O)C(F)(F)F InChI=1S/C27H28F4N6O3/c1-14-13-33-21(35-25(39)15-5-4-6-17(9-15)34-22(38)7-8-32)12-18(14)16-10-19-23(20(28)11-16)36-37(3)24(19)26(2,40)27(29,30)31/h10-13,15,17,40H,4-7,9H2,1-3H3,(H,34,38)(H,33,35,39)/t15-,17+,26-/m0/s1 KBJYBBVTVRWYJU-PXJNRBPISA-N 605607 US11673893, Example 76-2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.2 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605607&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136569 482598264 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286203 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2nn(C)c(c2c1)C(C)(O)C(F)(F)F InChI=1S/C26H29F4N5O3/c1-13-12-31-21(33-24(37)15-6-5-7-17(8-15)32-14(2)36)11-18(13)16-9-19-22(20(27)10-16)34-35(4)23(19)25(3,38)26(28,29)30/h9-12,15,17,38H,5-8H2,1-4H3,(H,32,36)(H,31,33,37)/t15-,17+,25?/m0/s1 CEERPSVTLJOQDZ-OCWAHVNLSA-N 605608 US11673893, Example 77 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.97 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605608&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146367 482598265 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286205 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(C)cn1)-c1cc(F)c2nn(C)c(c2c1)C(C)(O)C(F)F InChI=1S/C26H30F3N5O3/c1-13-12-30-21(32-24(36)15-6-5-7-17(8-15)31-14(2)35)11-18(13)16-9-19-22(20(27)10-16)33-34(4)23(19)26(3,37)25(28)29/h9-12,15,17,25,37H,5-8H2,1-4H3,(H,31,35)(H,30,32,36)/t15-,17+,26?/m0/s1 ACLSGVFCTLWIGY-DROLILFJSA-N 605609 US11673893, Example 78 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.05 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605609&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146426 482598266 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286207 Cc1cnc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)cc1-c1cc(F)c2nn(C)c(c2c1)C(C)(O)C(F)F InChI=1S/C27H29F3N6O3/c1-14-13-32-21(34-25(38)15-5-4-6-17(9-15)33-22(37)7-8-31)12-18(14)16-10-19-23(20(28)11-16)35-36(3)24(19)27(2,39)26(29)30/h10-13,15,17,26,39H,4-7,9H2,1-3H3,(H,33,37)(H,32,34,38)/t15-,17+,27?/m0/s1 JJGYTERWQYNFJU-SZEFBIPISA-N 605610 US11673893, Example 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.51 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605610&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146451 482598267 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286210 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1C InChI=1S/C26H29FN6O2/c1-15(2)33-14-30-25-21(27)10-18(11-22(25)33)20-12-23(29-13-16(20)3)32-26(35)17-5-4-6-19(9-17)31-24(34)7-8-28/h10-15,17,19H,4-7,9H2,1-3H3,(H,31,34)(H,29,32,35)/t17-,19+/m0/s1 FBECJLNJBCQUNR-PKOBYXMFSA-N 605611 US11673893, Example 80 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.09 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605611&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136561 482598268 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286212 COc1cnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)cc1-c1cc(F)c2ncn(C(C)C)c2c1 InChI=1S/C25H30FN5O3/c1-14(2)31-13-28-24-20(26)9-17(10-21(24)31)19-11-23(27-12-22(19)34-4)30-25(33)16-6-5-7-18(8-16)29-15(3)32/h9-14,16,18H,5-8H2,1-4H3,(H,29,32)(H,27,30,33)/t16-,18+/m0/s1 PTWJJWGFDVSDDI-FUHWJXTLSA-N 605612 US11673893, Example 81 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.2 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605612&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136504 482598269 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286214 CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)C23CC(C2)C3)ncc1Cl InChI=1S/C29H33ClFN5O2/c1-15(2)26-21-8-18(9-23(31)25(21)35-36(26)3)20-10-24(32-14-22(20)30)34-27(37)17-5-4-6-19(7-17)33-28(38)29-11-16(12-29)13-29/h8-10,14-17,19H,4-7,11-13H2,1-3H3,(H,33,38)(H,32,34,37)/t16?,17-,19+,29?/m0/s1 UOSJCNTXEITJHM-ZJDOGBEFSA-N 605613 US11673893, Example 82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.55 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605613&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136478 482598270 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286216 CC(C)n1nnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C23H26ClFN6O2/c1-12(2)31-20-9-15(8-19(25)22(20)29-30-31)17-10-21(26-11-18(17)24)28-23(33)14-5-4-6-16(7-14)27-13(3)32/h8-12,14,16H,4-7H2,1-3H3,(H,27,32)(H,26,28,33)/t14-,16+/m0/s1 DWXBFMUITVPAPQ-GOEBONIOSA-N 605614 US11673893, Example 83 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.9 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605614&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136563 482598271 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286219 CC(C)n1cnc2ccc(nc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C23H27ClN6O2/c1-13(2)30-12-26-20-8-7-19(28-22(20)30)17-10-21(25-11-18(17)24)29-23(32)15-5-4-6-16(9-15)27-14(3)31/h7-8,10-13,15-16H,4-6,9H2,1-3H3,(H,27,31)(H,25,29,32)/t15-,16+/m0/s1 CWGBJAZDOLEZBX-JKSUJKDBSA-N 605615 US11673893, Example 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.42 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605615&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136466 482598272 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286221 CC1(C)COCc2nc3c(F)cc(cc3n12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1Cl InChI=1S/C27H28ClFN6O3/c1-27(2)14-38-13-23-34-25-20(29)9-16(10-21(25)35(23)27)18-11-22(31-12-19(18)28)33-26(37)15-4-3-5-17(8-15)32-24(36)6-7-30/h9-12,15,17H,3-6,8,13-14H2,1-2H3,(H,32,36)(H,31,33,37)/t15-,17+/m0/s1 MSSWEISDYNQLGE-DOTOQJQBSA-N 605616 US11673893, Example 85 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.83 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605616&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136560 482598273 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286223 Cn1nc2c(F)cc(cc2c1C(C)(C)O)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1Cl InChI=1S/C26H28ClFN6O3/c1-26(2,37)24-18-10-15(11-20(28)23(18)33-34(24)3)17-12-21(30-13-19(17)27)32-25(36)14-5-4-6-16(9-14)31-22(35)7-8-29/h10-14,16,37H,4-7,9H2,1-3H3,(H,31,35)(H,30,32,36)/t14-,16+/m0/s1 HRLKJDPJDKEXFB-GOEBONIOSA-N 605617 US11673893, Example 86 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.406 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605617&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156146439 482598274 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286226 CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C24H27ClFN5O2/c1-13(2)31-12-28-23-20(26)8-16(9-21(23)31)18-10-22(27-11-19(18)25)30-24(33)15-5-4-6-17(7-15)29-14(3)32/h8-13,15,17H,4-7H2,1-3H3,(H,29,32)(H,27,30,33)/t15-,17+/m0/s1 CIVWJLUNRPRKCE-DOTOQJQBSA-N 605618 US11673893, Example 87 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.837 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605618&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136530 482598275 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1286228 CC(C)n1cnc2c(F)cc(cc12)-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 InChI=1S/C24H28FN5O2/c1-14(2)30-13-27-23-20(25)10-18(11-21(23)30)16-7-8-26-22(12-16)29-24(32)17-5-4-6-19(9-17)28-15(3)31/h7-8,10-14,17,19H,4-6,9H2,1-3H3,(H,28,31)(H,26,29,32)/t17-,19+/m0/s1 MPVZZUVYXJBYBN-PKOBYXMFSA-N 605619 US11673893, Example 88 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.22 US Patent 10.7270/Q2J38XHJ US11673893 Lu, L; Shetty, R; Combs, AP; Dai, C; Leal, RA; Bersch, KL Prelude Therapeutics Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605619&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156136584 482598276 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333612 C1CC1c1cnn2ccc(nc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)n1 InChI=1S/C24H31N7O/c1-2-16(1)20-15-26-31-12-8-22(29-23(20)31)21-7-11-25-24(30-21)28-18-5-3-17(4-6-18)27-19-9-13-32-14-10-19/h7-8,11-12,15-19,27H,1-6,9-10,13-14H2,(H,25,28,30)/t17-,18- JLZKEHYFAPFESP-IYARVYRRSA-N 625577 US20230322792, Example I-1::trans-N1-[4-[(3- cyclopropyl) pyrazolo[1,5- a]pyrimidin-5- yl]pyrimidin-2- y1]-N4- (tetrahydro-2H- pyran-4- yl)cyclohexane- 1,4-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625577&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291411 485207905 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333613 C1CC(C1)c1cnn2ccc(nc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)n1 InChI=1S/C25H33N7O/c1-2-17(3-1)21-16-27-32-13-9-23(30-24(21)32)22-8-12-26-25(31-22)29-19-6-4-18(5-7-19)28-20-10-14-33-15-11-20/h8-9,12-13,16-20,28H,1-7,10-11,14-15H2,(H,26,29,31)/t18-,19- AGANLBNQOALZFC-WGSAOQKQSA-N 625578 US20230322792, Example I-2::trans-N1-[4-[(3- cyclobutyl) pyrazolo[1,5- a]pyrimidin-5- yl]pyrimidin-2- y1]- 24- (tetrahydro-2H- pyran-4- yl)cyclohexane- 1,4-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625578&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291440 485207906 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333614 CC(C)c1cnn2ccc(nc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)n1 InChI=1S/C24H33N7O/c1-16(2)20-15-26-31-12-8-22(29-23(20)31)21-7-11-25-24(30-21)28-18-5-3-17(4-6-18)27-19-9-13-32-14-10-19/h7-8,11-12,15-19,27H,3-6,9-10,13-14H2,1-2H3,(H,25,28,30)/t17-,18- ZMWCHODNAZMKER-IYARVYRRSA-N 625579 US20230322792, Example I-3::trans-N1-[4-[(3- isopropyl) pyrazolo[1,5- a]pyrimidin-5- yl]pyrimidin-2- yl]- N4_ (tetrahydro-2H- pyran-4- yl)cyclohexane- 1,4-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291405 485207907 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333615 O[C@@H]1CNCC[C@H]1CNc1nccc(n1)-c1ccn2ncc(C3CC3)c2n1 InChI=1S/C19H23N7O/c27-17-11-20-6-3-13(17)9-22-19-21-7-4-15(25-19)16-5-8-26-18(24-16)14(10-23-26)12-1-2-12/h4-5,7-8,10,12-13,17,20,27H,1-3,6,9,11H2,(H,21,22,25)/t13-,17+/m0/s1 AUOYONJLQKHAOF-SUMWQHHRSA-N 625580 US20230322792, Example I-4::trans-5-[2-(3- hydroxypiperidin- 4- yl)methylamino- pyrimidin- 4-yl]-3- cyclopropyl pyrazolo[1, 5- a]pyrimidine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625580&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291401 485207908 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333616 O[C@@H]1CNCC[C@H]1CNc1nccc(n1)-c1ccn2ncc(C3CCC3)c2n1 InChI=1S/C20H25N7O/c28-18-12-21-7-4-14(18)10-23-20-22-8-5-16(26-20)17-6-9-27-19(25-17)15(11-24-27)13-2-1-3-13/h5-6,8-9,11,13-14,18,21,28H,1-4,7,10,12H2,(H,22,23,26)/t14-,18+/m0/s1 HYUPPQURXALDHW-KBXCAEBGSA-N 625581 US20230322792, Example I-5::trans-5-[2-(3- hydroxypiperidin- 4- yl)methylamino- pyrimidin-4-yl]-3- cyclobutyl pyrazolo[1, 5- a]pyrimidine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625581&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291438 485207909 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333617 CC(C)c1cnn2ccc(nc12)-c1ccnc(NC[C@@H]2CCNC[C@H]2O)n1 InChI=1S/C19H25N7O/c1-12(2)14-10-23-26-8-5-16(24-18(14)26)15-4-7-21-19(25-15)22-9-13-3-6-20-11-17(13)27/h4-5,7-8,10,12-13,17,20,27H,3,6,9,11H2,1-2H3,(H,21,22,25)/t13-,17+/m0/s1 ZCWFEGCMXCDFGV-SUMWQHHRSA-N 625582 US20230322792, Example I-6::trans-5-[2-(3- hydroxypiperidin- 4- yl)methylamino- pyrimidin-4-yl]-3- isopropylpyrazolo [1, 5- a]pyrimidine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625582&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291409 485207910 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333618 O[C@@H]1CNCC[C@H]1CNc1nccc(n1)-c1ccn2nccc2n1 InChI=1S/C16H19N7O/c24-14-10-17-5-1-11(14)9-19-16-18-6-2-12(22-16)13-4-8-23-15(21-13)3-7-20-23/h2-4,6-8,11,14,17,24H,1,5,9-10H2,(H,18,19,22)/t11-,14+/m0/s1 IBBIWINYFYLDCW-SMDDNHRTSA-N 625583 US20230322792, Example I-7::trans-5-[2-(3- hydroxypiperidin- 4- yl)methylamino pyrimidin-4- yl]pyrazolo[1, 5- a]pyrimidine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625583&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291399 485207911 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333619 C1CC(CCN1)Nc1nccc(n1)-c1ccn2nccc2n1 InChI=1S/C15H17N7/c1-6-16-7-2-11(1)19-15-17-8-3-12(21-15)13-5-10-22-14(20-13)4-9-18-22/h3-5,8-11,16H,1-2,6-7H2,(H,17,19,21) AEKMJVZPWDVGFO-UHFFFAOYSA-N 625584 US20230322792, Example I-8::trans-5-[2- (piperidin-4- yl)aminopyrimidin- 4- yl]pyrazolo[1,5- a]pyrimidine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625584&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291410 485207912 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333620 N[C@H]1CC[C@H](C1)Nc1nccc(n1)-c1ccn2nccc2n1 InChI=1S/C15H17N7/c16-10-1-2-11(9-10)19-15-17-6-3-12(21-15)13-5-8-22-14(20-13)4-7-18-22/h3-8,10-11H,1-2,9,16H2,(H,17,19,21)/t10-,11+/m0/s1 SHRJHEWREJLJIT-WDEREUQCSA-N 625585 (1S,3R)-[3-[4- [pyrazolo[1,5- a]pyrimidin-5- yl]pyrimidin-2- yl]aminocyclo- pentan-1-yl]-1,3- diamine::US20230322792, Example I-9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625585&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169234722 485207913 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333621 C1CC(CCO1)N[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1ccn2nccc2n1 InChI=1S/C21H27N7O/c1-3-16(4-2-15(1)24-17-8-13-29-14-9-17)25-21-22-10-5-18(27-21)19-7-12-28-20(26-19)6-11-23-28/h5-7,10-12,15-17,24H,1-4,8-9,13-14H2,(H,22,25,27)/t15-,16- VPEFZZCLSCVJEJ-WKILWMFISA-N 625586 US20230322792, Example I-10::trans-N1-[4- [pyrazolo[1,5- a]pyrimidin-5- yl]pyrimidin-2- yl]- N4- (tetrahydro-2H- pyran-4- yl)cyclohexane- 1,4-diamine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625586&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291416 485207914 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333622 N[C@H]1CC[C@@H](C1)Nc1nccc(n1)-c1ccn2nccc2n1 InChI=1S/C15H17N7/c16-10-1-2-11(9-10)19-15-17-6-3-12(21-15)13-5-8-22-14(20-13)4-7-18-22/h3-8,10-11H,1-2,9,16H2,(H,17,19,21)/t10-,11-/m0/s1 SHRJHEWREJLJIT-QWRGUYRKSA-N 625587 (1S, 3S)-[3-[4- [pyrazolo[1,5- a]pyrimidin-5- yl]pyrimidin-2- yl]aminocyclo- pentan-1-yl]-1,3- diamine::US20230322792, Example I-11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625587&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169291404 485207915 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333623 Cc1cnn2ccc(nc12)-c1ccnc(N[C@H]2CC[C@H](N)C2)n1 InChI=1S/C16H19N7/c1-10-9-19-23-7-5-14(21-15(10)23)13-4-6-18-16(22-13)20-12-3-2-11(17)8-12/h4-7,9,11-12H,2-3,8,17H2,1H3,(H,18,20,22)/t11-,12-/m0/s1 QKWURYRIKUCZRL-RYUDHWBXSA-N 625588 (1S, 3S)-[3-[4-[3- methylpyrazolo [1,5-a]pyrimidin- 5-yl]pyrimidin-2- yl]aminocyclo- pentan-1-yl]-1,3- diamine::US20230322792, Example I-12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625588&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169234726 485207916 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333624 Cc1cc2nc(ccn2n1)-c1ccnc(N[C@H]2CC[C@H](N)C2)n1 InChI=1S/C16H19N7/c1-10-8-15-20-14(5-7-23(15)22-10)13-4-6-18-16(21-13)19-12-3-2-11(17)9-12/h4-8,11-12H,2-3,9,17H2,1H3,(H,18,19,21)/t11-,12-/m0/s1 IKONDKHJORQUFA-RYUDHWBXSA-N 625589 (1S,3S)-[3-[4-[2- methylpyrazolo [1,5-a]pyrimidin- 5-yl]pyrimidin-2- yl]aminocyclo- pentan-1-yl]-1,3- diamine::US20230322792, Example I-13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7500 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625589&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169234728 485207917 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1333625 CC(C)c1cnn2ccc(nc12)-c1ccnc(N[C@H]2CC[C@H](N)C2)n1 InChI=1S/C18H23N7/c1-11(2)14-10-21-25-8-6-16(23-17(14)25)15-5-7-20-18(24-15)22-13-4-3-12(19)9-13/h5-8,10-13H,3-4,9,19H2,1-2H3,(H,20,22,24)/t12-,13-/m0/s1 PPHRABROTWKRRT-STQMWFEESA-N 625590 (1S,3S)-[3-[4-[3- isopropylpyrazolo [1,5- a]pyrimidin-5- yl]pyrimidin-2- yl]aminocyclo- pentan-1-yl]-1,3- diamine::US20230322792, Example I-14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <1000 US Patent 10.7270/Q2WS8ZDM US20230322792 Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ Biolexis Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=625590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=625590&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169234720 485207918 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325869 Cc1cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2c(N[C@@H]2CCC[C@@]2(C)O)n1 InChI=1S/C20H30N6O3S/c1-13-11-14-12-21-19(23-15-6-9-26(10-7-15)30(3,28)29)25-17(14)18(22-13)24-16-5-4-8-20(16,2)27/h11-12,15-16,27H,4-10H2,1-3H3,(H,22,24)(H,21,23,25)/t16-,20-/m1/s1 AAVOJGZMGDAVNM-OXQOHEQNSA-N 621172 US20230303564, Compound 6::US20230303564, Compound 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621172&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169076003 485228329 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325876 CS(=O)(=O)N1CCC(CC1)Sc1ncc2ccnc(C3CCCC3O)c2n1 InChI=1S/C18H24N4O3S2/c1-27(24,25)22-9-6-13(7-10-22)26-18-20-11-12-5-8-19-17(16(12)21-18)14-3-2-4-15(14)23/h5,8,11,13-15,23H,2-4,6-7,9-10H2,1H3 GAASHZGNZTYOCB-UHFFFAOYSA-N 621174 US20230303564, Compound 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 303 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621174&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169429064 485228330 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325887 Cc1cn(C)nc1Nc1nc(cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc12)C(F)F InChI=1S/C19H24F2N8O2S/c1-11-10-28(2)27-17(11)26-18-15-12(8-14(24-18)16(20)21)9-22-19(25-15)23-13-4-6-29(7-5-13)32(3,30)31/h8-10,13,16H,4-7H2,1-3H3,(H,22,23,25)(H,24,26,27) IFYFSFOYHMKQFI-UHFFFAOYSA-N 621177 US20230303564, Compound 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 178 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621177&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169075922 485228333 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325891 Cn1cc(Cl)c(Nc2nc(cc3cnc(NC4CCN(CC4)S(C)(=O)=O)nc23)C(F)F)n1 InChI=1S/C18H21ClF2N8O2S/c1-28-9-12(19)16(27-28)26-17-14-10(7-13(24-17)15(20)21)8-22-18(25-14)23-11-3-5-29(6-4-11)32(2,30)31/h7-9,11,15H,3-6H2,1-2H3,(H,22,23,25)(H,24,26,27) FKBJNZVFLUJSNG-UHFFFAOYSA-N 621178 US20230303564, Compound 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 106 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621178&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169076007 485228334 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325897 CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(nc(N[C@H]3CCCC3(F)F)c2n1)C(F)F InChI=1S/C19H24F4N6O2S/c1-32(30,31)29-7-4-12(5-8-29)25-18-24-10-11-9-13(16(20)21)26-17(15(11)28-18)27-14-3-2-6-19(14,22)23/h9-10,12,14,16H,2-8H2,1H3,(H,26,27)(H,24,25,28)/t14-/m0/s1 DJXMWMFZMCZDNH-AWEZNQCLSA-N 621179 US20230303564, Compound 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621179&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169076011 485228335 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325903 CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(nc(N[C@@H]3CCCC3(F)F)c2n1)C(F)F InChI=1S/C19H24F4N6O2S/c1-32(30,31)29-7-4-12(5-8-29)25-18-24-10-11-9-13(16(20)21)26-17(15(11)28-18)27-14-3-2-6-19(14,22)23/h9-10,12,14,16H,2-8H2,1H3,(H,26,27)(H,24,25,28)/t14-/m1/s1 DJXMWMFZMCZDNH-CQSZACIVSA-N 621180 US20230303564, Compound 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.9 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621180&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169075948 485228336 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1325907 C[C@@H]1CN(CC[C@@H]1Nc1ncc2cc(nc(N[C@H]3CCCC3(F)F)c2n1)C(F)F)C(=O)OC(C)(C)C InChI=1S/C24H32F4N6O2/c1-13-12-34(22(35)36-23(2,3)4)9-7-15(13)31-21-29-11-14-10-16(19(25)26)30-20(18(14)33-21)32-17-6-5-8-24(17,27)28/h10-11,13,15,17,19H,5-9,12H2,1-4H3,(H,30,32)(H,29,31,33)/t13-,15+,17+/m1/s1 IUCBKFYHAZXUSO-KMFMINBZSA-N 621181 US20230303564, Compound 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 214 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621181&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169429065 485228337 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51506579 CN1CCN(CC1)c1ccc(Nc2ncc3nc(C(C)=O)c(=O)n(C4CCCC4)c3n2)cc1 InChI=1S/C24H29N7O2/c1-16(32)21-23(33)31(19-5-3-4-6-19)22-20(27-21)15-25-24(28-22)26-17-7-9-18(10-8-17)30-13-11-29(2)12-14-30/h7-10,15,19H,3-6,11-14H2,1-2H3,(H,25,26,28) CPKLUQZOENPOAC-UHFFFAOYSA-N 50606945 CHEMBL5218782 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 ChEMBL 10.7270/Q28S4V1B 36130661 He, H; Liu, Q; Chen, L; Wang, J; Yuan, Y; Li, H; Qian, X; Zhao, Z; Chen, Z East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50606945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50606945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 168299155 482617796 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51506580 CCN1CCN(CC1)c1ccc(Nc2ncc3nc(C(C)=O)c(=O)n(C4CCCC4)c3n2)cc1 InChI=1S/C25H31N7O2/c1-3-30-12-14-31(15-13-30)19-10-8-18(9-11-19)27-25-26-16-21-23(29-25)32(20-6-4-5-7-20)24(34)22(28-21)17(2)33/h8-11,16,20H,3-7,12-15H2,1-2H3,(H,26,27,29) JWXFZMDNUUBYBZ-UHFFFAOYSA-N 50606946 CHEMBL5220823 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8043 ChEMBL 10.7270/Q28S4V1B 36130661 He, H; Liu, Q; Chen, L; Wang, J; Yuan, Y; Li, H; Qian, X; Zhao, Z; Chen, Z East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50606946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50606946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167312199 482617797 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 51506581 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23 ChEMBL 10.7270/Q28S4V1B 36130661 He, H; Liu, Q; Chen, L; Wang, J; Yuan, Y; Li, H; Qian, X; Zhao, Z; Chen, Z East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361749 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib::US20230416221, Compound Dinaciclib Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361750 C[C@@H](NC(=O)[C@H](CCN(CC1CCCC1)CC(O)=O)NC(C)=O)C(=O)NO InChI=1S/C17H30N4O6/c1-11(16(25)20-27)18-17(26)14(19-12(2)22)7-8-21(10-15(23)24)9-13-5-3-4-6-13/h11,13-14,27H,3-10H2,1-2H3,(H,18,26)(H,19,22)(H,20,25)(H,23,24)/t11-,14+/m1/s1 CZUXSTKXXAXBTE-RISCZKNCSA-N 642543 2-[[(3S)-3-acetamido-4-[[(2R)-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-4-oxidanylidene-butyl]-(cyclopentylmethyl)amino]ethanoic acid::HY9::US20230416221, Compound HY-009 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642543&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 7E63 162625295 488875397 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361751 COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25) YZCUMZWULWOUMD-UHFFFAOYSA-N 50553483 CHEMBL4756595::US20230416221, Compound BAY1251152 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.3 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553483&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 74767009 461692251 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361752 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14::US20230416221, Compound AZD4573 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361753 COCCN[C@H]1CCC(CC1)Nc1nccc(n1)-c1ccc2C(=O)NCCc2c1 InChI=1S/C22H29N5O2/c1-29-13-12-23-17-3-5-18(6-4-17)26-22-25-11-9-20(27-22)16-2-7-19-15(14-16)8-10-24-21(19)28/h2,7,9,11,14,17-18,23H,3-6,8,10,12-13H2,1H3,(H,24,28)(H,25,26,27)/t17-,18? LKIZNAHDTDBORF-FNGKDXACSA-N 642546 US20230416221, Compound 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642546&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170148275 488875400 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361754 COCCN[C@H]1CCC(CC1)Nc1nccc(n1)-c1ccc2C(=O)NCC(C)(C)c2c1 InChI=1S/C24H33N5O2/c1-24(2)15-27-22(30)19-9-4-16(14-20(19)24)21-10-11-26-23(29-21)28-18-7-5-17(6-8-18)25-12-13-31-3/h4,9-11,14,17-18,25H,5-8,12-13,15H2,1-3H3,(H,27,30)(H,26,28,29)/t17-,18? PLKZELWSZVVZSB-FNGKDXACSA-N 642547 US20230416221, Compound 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.1 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642547&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081042 488875401 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361755 COCCN[C@H]1CCC(CC1)Nc1ncc(F)c(n1)-c1ccc2C(=O)NC(C)(C)c2c1 InChI=1S/C23H30FN5O2/c1-23(2)18-12-14(4-9-17(18)21(30)29-23)20-19(24)13-26-22(28-20)27-16-7-5-15(6-8-16)25-10-11-31-3/h4,9,12-13,15-16,25H,5-8,10-11H2,1-3H3,(H,29,30)(H,26,27,28)/t15-,16? NXPPICHDIHOSIW-JGIIQEAISA-N 642548 US20230416221, Compound 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.04 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642548&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170148298 488875402 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361756 COCCN[C@H]1CCC(CC1)Nc1ncc(Cl)c(n1)-c1ccc2C(=O)NC(C)(C)c2c1 InChI=1S/C23H30ClN5O2/c1-23(2)18-12-14(4-9-17(18)21(30)29-23)20-19(24)13-26-22(28-20)27-16-7-5-15(6-8-16)25-10-11-31-3/h4,9,12-13,15-16,25H,5-8,10-11H2,1-3H3,(H,29,30)(H,26,27,28)/t15-,16? XRNBJWFRZNMKHS-JGIIQEAISA-N 642549 US20230416221, Compound 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642549&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170148300 488875403 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361757 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C21H21N5O3S/c1-21(2)12-24-19(27)16-7-6-13(10-17(16)21)18-8-9-23-20(26-18)25-14-4-3-5-15(11-14)30(22,28)29/h3-11H,12H2,1-2H3,(H,24,27)(H2,22,28,29)(H,23,25,26) UVFKMQNAWGVTFS-UHFFFAOYSA-N 642550 US20230416221, Compound 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3.10 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642550&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 163364236 488875404 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361758 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2cccc(CS(N)(=O)=O)c2)n1 InChI=1S/C22H23N5O3S/c1-22(2)13-25-20(28)17-7-6-15(11-18(17)22)19-8-9-24-21(27-19)26-16-5-3-4-14(10-16)12-31(23,29)30/h3-11H,12-13H2,1-2H3,(H,25,28)(H2,23,29,30)(H,24,26,27) SZZMGLSADKOJKF-UHFFFAOYSA-N 642551 US20230416221, Compound 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.890 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642551&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169220699 488875405 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361759 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1 InChI=1S/C23H24N4O3S/c1-23(2)14-25-21(28)18-8-7-16(12-19(18)23)20-9-10-24-22(27-20)26-17-6-4-5-15(11-17)13-31(3,29)30/h4-12H,13-14H2,1-3H3,(H,25,28)(H,24,26,27) PHHHURPMPCTKCD-UHFFFAOYSA-N 642552 US20230416221, Compound 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642552&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081037 488875406 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361760 CN(C)S(=O)(=O)c1cccc(Nc2nccc(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)c1 InChI=1S/C23H25N5O3S/c1-23(2)14-25-21(29)18-9-8-15(12-19(18)23)20-10-11-24-22(27-20)26-16-6-5-7-17(13-16)32(30,31)28(3)4/h5-13H,14H2,1-4H3,(H,25,29)(H,24,26,27) DWGXKULJXCBVJS-UHFFFAOYSA-N 642553 US20230416221, Compound 29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642553&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081018 488875407 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361761 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2cccc(c2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C25H27N5O4S/c1-25(2)16-27-23(31)20-7-6-17(14-21(20)25)22-8-9-26-24(29-22)28-18-4-3-5-19(15-18)35(32,33)30-10-12-34-13-11-30/h3-9,14-15H,10-13,16H2,1-2H3,(H,27,31)(H,26,28,29) VOLYAYXWMITTMZ-UHFFFAOYSA-N 642554 US20230416221, Compound 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642554&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169220705 488875408 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361762 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2ccc(F)c(NS(C)(=O)=O)c2)n1 InChI=1S/C22H22FN5O3S/c1-22(2)12-25-20(29)15-6-4-13(10-16(15)22)18-8-9-24-21(27-18)26-14-5-7-17(23)19(11-14)28-32(3,30)31/h4-11,28H,12H2,1-3H3,(H,25,29)(H,24,26,27) XHCIZQMNGCEBGR-UHFFFAOYSA-N 642555 US20230416221, Compound 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.10 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642555&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080959 488875409 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361763 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2ccc(F)c(CS(C)(=O)=O)c2)n1 InChI=1S/C23H23FN4O3S/c1-23(2)13-26-21(29)17-6-4-14(11-18(17)23)20-8-9-25-22(28-20)27-16-5-7-19(24)15(10-16)12-32(3,30)31/h4-11H,12-13H2,1-3H3,(H,26,29)(H,25,27,28) MXAHLILGCUCMBC-UHFFFAOYSA-N 642556 US20230416221, Compound 36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.10 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642556&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081000 488875410 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361764 CN1CCN(CC1)c1cccc(Nc2nccc(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)c1 InChI=1S/C26H30N6O/c1-26(2)17-28-24(33)21-8-7-18(15-22(21)26)23-9-10-27-25(30-23)29-19-5-4-6-20(16-19)32-13-11-31(3)12-14-32/h4-10,15-16H,11-14,17H2,1-3H3,(H,28,33)(H,27,29,30) HOXZZCZMYMAZFB-UHFFFAOYSA-N 642557 US20230416221, Compound 37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.80 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642557&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080980 488875411 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361765 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1 InChI=1S/C22H22N4O3S/c1-22(2)13-24-20(27)17-9-4-14(12-18(17)22)19-10-11-23-21(26-19)25-15-5-7-16(8-6-15)30(3,28)29/h4-12H,13H2,1-3H3,(H,24,27)(H,23,25,26) PDHUXFWSGVBZNI-UHFFFAOYSA-N 642558 US20230416221, Compound 39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.70 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642558&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081031 488875412 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361766 CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)cc1 InChI=1S/C26H30N6O/c1-26(2)17-28-24(33)21-9-4-18(16-22(21)26)23-10-11-27-25(30-23)29-19-5-7-20(8-6-19)32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H,28,33)(H,27,29,30) GHSRRDOZOGQMBP-UHFFFAOYSA-N 642559 US20230416221, Compound 40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.60 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642559&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080984 488875413 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361767 CN1CCC(CC1)NC(=O)c1cc(Nc2nccc(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)ccc1F InChI=1S/C28H31FN6O2/c1-28(2)16-31-25(36)20-6-4-17(14-22(20)28)24-8-11-30-27(34-24)33-19-5-7-23(29)21(15-19)26(37)32-18-9-12-35(3)13-10-18/h4-8,11,14-15,18H,9-10,12-13,16H2,1-3H3,(H,31,36)(H,32,37)(H,30,33,34) IZQPKIPMZNTQPB-UHFFFAOYSA-N 642560 US20230416221, Compound 41 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.50 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642560&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080963 488875414 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361768 Cc1ccc(Nc2nccc(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)cc1CS(C)(=O)=O InChI=1S/C24H26N4O3S/c1-15-5-7-18(11-17(15)13-32(4,30)31)27-23-25-10-9-21(28-23)16-6-8-19-20(12-16)24(2,3)14-26-22(19)29/h5-12H,13-14H2,1-4H3,(H,26,29)(H,25,27,28) QXBWYVCMKYHWQB-UHFFFAOYSA-N 642561 US20230416221, Compound 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.20 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642561&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080974 488875415 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361769 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2ccc(c(CS(C)(=O)=O)c2)C(F)(F)F)n1 InChI=1S/C24H23F3N4O3S/c1-23(2)13-29-21(32)17-6-4-14(11-19(17)23)20-8-9-28-22(31-20)30-16-5-7-18(24(25,26)27)15(10-16)12-35(3,33)34/h4-11H,12-13H2,1-3H3,(H,29,32)(H,28,30,31) FNKRJRUAEDTXEZ-UHFFFAOYSA-N 642562 US20230416221, Compound 44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642562&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080995 488875416 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361770 CC1(C)NC(=O)c2ccc(cc12)-c1ccnc(Nc2ccc(F)c(CS(C)(=O)=O)c2)n1 InChI=1S/C22H21FN4O3S/c1-22(2)17-11-13(4-6-16(17)20(28)27-22)19-8-9-24-21(26-19)25-15-5-7-18(23)14(10-15)12-31(3,29)30/h4-11H,12H2,1-3H3,(H,27,28)(H,24,25,26) RELMUQLAIBGESW-UHFFFAOYSA-N 642563 US20230416221, Compound 48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.90 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642563&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081023 488875417 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361771 CC1(C)NC(=O)c2ccc(cc12)-c1ccnc(Nc2ccc(CS(C)(=O)=O)cc2)n1 InChI=1S/C22H22N4O3S/c1-22(2)18-12-15(6-9-17(18)20(27)26-22)19-10-11-23-21(25-19)24-16-7-4-14(5-8-16)13-30(3,28)29/h4-12H,13H2,1-3H3,(H,26,27)(H,23,24,25) SNSGGCFOVTXDBT-UHFFFAOYSA-N 642564 US20230416221, Compound 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642564&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080976 488875418 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361772 CC1(C)NC(=O)c2ccc(cc12)-c1nc(Nc2ccc(F)c(CS(C)(=O)=O)c2)ncc1F InChI=1S/C22H20F2N4O3S/c1-22(2)16-9-12(4-6-15(16)20(29)28-22)19-18(24)10-25-21(27-19)26-14-5-7-17(23)13(8-14)11-32(3,30)31/h4-10H,11H2,1-3H3,(H,28,29)(H,25,26,27) QVKRVOPXJKCOCT-UHFFFAOYSA-N 642565 US20230416221, Compound 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.59 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642565&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169220700 488875419 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361773 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2ccnc(CS(C)(=O)=O)c2)n1 InChI=1S/C22H23N5O3S/c1-22(2)13-25-20(28)17-5-4-14(10-18(17)22)19-7-9-24-21(27-19)26-15-6-8-23-16(11-15)12-31(3,29)30/h4-11H,12-13H2,1-3H3,(H,25,28)(H,23,24,26,27) GBJDSDHNWFITCF-UHFFFAOYSA-N 642566 US20230416221, Compound 56 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.20 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642566&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169081006 488875420 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361774 CN1CCN(CC1)c1cc(Nc2ncc(F)c(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)ccc1F InChI=1S/C26H28F2N6O/c1-26(2)15-30-24(35)18-6-4-16(12-19(18)26)23-21(28)14-29-25(32-23)31-17-5-7-20(27)22(13-17)34-10-8-33(3)9-11-34/h4-7,12-14H,8-11,15H2,1-3H3,(H,30,35)(H,29,31,32) NFWZSOQHEDNRFN-UHFFFAOYSA-N 642567 US20230416221, Compound 72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642567&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080969 488875421 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361775 CN1CCN(CC1)c1cc(Nc2nccc(n2)-c2ccc3C(=O)NCC(C)(C)c3c2)ccc1C InChI=1S/C27H32N6O/c1-18-5-7-20(16-24(18)33-13-11-32(4)12-14-33)30-26-28-10-9-23(31-26)19-6-8-21-22(15-19)27(2,3)17-29-25(21)34/h5-10,15-16H,11-14,17H2,1-4H3,(H,29,34)(H,28,30,31) GBQLXIBQSWXLCZ-UHFFFAOYSA-N 642568 US20230416221, Compound 82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.60 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642568&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170148342 488875422 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361776 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1ccc2C(=O)NCC(C)(C)c2c1 InChI=1S/C25H29ClN4O3/c1-14(31)29-17-6-4-5-16(9-17)23(32)30-22-11-19(21(26)12-27-22)15-7-8-18-20(10-15)25(2,3)13-28-24(18)33/h7-8,10-12,16-17H,4-6,9,13H2,1-3H3,(H,28,33)(H,29,31)(H,27,30,32)/t16-,17+/m0/s1 KPSQLGOXCQASJV-DLBZAZTESA-N 642569 US20230416221, Compound 96 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.520 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642569&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170542197 488875423 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361777 CC1(C)CNC(=O)c2ccc(cc12)-c1nc(Nc2ccc(CS(C)(=O)=O)cn2)ncc1Cl InChI=1S/C22H22ClN5O3S/c1-22(2)12-26-20(29)15-6-5-14(8-16(15)22)19-17(23)10-25-21(28-19)27-18-7-4-13(9-24-18)11-32(3,30)31/h4-10H,11-12H2,1-3H3,(H,26,29)(H,24,25,27,28) NHGFAMKSISSQFR-UHFFFAOYSA-N 642570 US20230416221, Compound 99 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.30 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642570&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170542190 488875424 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361778 CC1(C)CNC(=O)c2ccc(cc12)-c1nc(Nc2ccc(CS(C)(=O)=O)cn2)ncc1F InChI=1S/C22H22FN5O3S/c1-22(2)12-26-20(29)15-6-5-14(8-16(15)22)19-17(23)10-25-21(28-19)27-18-7-4-13(9-24-18)11-32(3,30)31/h4-10H,11-12H2,1-3H3,(H,26,29)(H,24,25,27,28) KRPCWSYLKGXILC-UHFFFAOYSA-N 642571 US20230416221, Compound 100 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.90 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642571&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170542189 488875425 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361779 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(N[C@@H]2CCCN(C2)S(C)(=O)=O)n1 InChI=1S/C21H27N5O3S/c1-21(2)13-23-19(27)16-7-6-14(11-17(16)21)18-8-9-22-20(25-18)24-15-5-4-10-26(12-15)30(3,28)29/h6-9,11,15H,4-5,10,12-13H2,1-3H3,(H,23,27)(H,22,24,25)/t15-/m1/s1 BPILPZDIYRQTTE-OAHLLOKOSA-N 642572 US20230416221, Compound 104 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 0.900 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642572&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170542192 488875426 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361780 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(NC2CCN(CC2)S(C)(=O)=O)n1 InChI=1S/C21H27N5O3S/c1-21(2)13-23-19(27)16-5-4-14(12-17(16)21)18-6-9-22-20(25-18)24-15-7-10-26(11-8-15)30(3,28)29/h4-6,9,12,15H,7-8,10-11,13H2,1-3H3,(H,23,27)(H,22,24,25) ICNWPIVTOQLOOY-UHFFFAOYSA-N 642573 US20230416221, Compound 105 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642573&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169080967 488875427 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1361781 CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(NC2CCN(CC(O)=O)CC2)n1 InChI=1S/C22H27N5O3/c1-22(2)13-24-20(30)16-4-3-14(11-17(16)22)18-5-8-23-21(26-18)25-15-6-9-27(10-7-15)12-19(28)29/h3-5,8,11,15H,6-7,9-10,12-13H2,1-2H3,(H,24,30)(H,28,29)(H,23,25,26) OQPCGXIQNQAOFQ-UHFFFAOYSA-N 642574 US20230416221, Compound 106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.4 US Patent 10.7270/Q2JH3RBG US20230416221 LIU, Q; LIU, J; WU, Y; WANG, B; WANG, A; HU, C; LIU, Q; ZOU, F; WANG, W; WANG, Z; CAO, J; SHI, C; WANG, L Hefei Institutes Of Physical Science, Chinese Academy Of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642574&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 170542193 488875428 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1362154 CC(C)c1noc2ccc3cnc(N[C@H]4CC[C@@H](CC4)NC4CCOCC4)nc3c12 InChI=1S/C23H31N5O2/c1-14(2)21-20-19(30-28-21)8-3-15-13-24-23(27-22(15)20)26-17-6-4-16(5-7-17)25-18-9-11-29-12-10-18/h3,8,13-14,16-18,25H,4-7,9-12H2,1-2H3,(H,24,26,27)/t16-,17- WVMNAFHMDQOKIP-QAQDUYKDSA-N 642732 US20230416271, Compound I.1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2WS8ZF2 US20230416271 Cheng, H; Xiong, W; Niu, W; Yu, B; Jiang, Y Chengdu Cynogen Bio-Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642732&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167088680 488875578 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1362155 CC(C)c1noc2ccc3cnc(N[C@H]4CC[C@@H](CC4)NC4CCNCC4)nc3c12 InChI=1S/C23H32N6O/c1-14(2)21-20-19(30-29-21)8-3-15-13-25-23(28-22(15)20)27-17-6-4-16(5-7-17)26-18-9-11-24-12-10-18/h3,8,13-14,16-18,24,26H,4-7,9-12H2,1-2H3,(H,25,27,28)/t16-,17- ZFCILQSOMHMEON-QAQDUYKDSA-N 642733 US20230416271, Compound I.2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2WS8ZF2 US20230416271 Cheng, H; Xiong, W; Niu, W; Yu, B; Jiang, Y Chengdu Cynogen Bio-Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642733&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167088715 488875579 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1362156 CC(C)n1nnc2ccc3cnc(N[C@H]4CC[C@@H](CC4)NC4CCOCC4)nc3c12 InChI=1S/C22H31N7O/c1-14(2)29-21-19(27-28-29)8-3-15-13-23-22(26-20(15)21)25-17-6-4-16(5-7-17)24-18-9-11-30-12-10-18/h3,8,13-14,16-18,24H,4-7,9-12H2,1-2H3,(H,23,25,26)/t16-,17- MDFHINIKLRTFAE-QAQDUYKDSA-N 642748 (1R,4R)-N1-(1-isopropyl-1H-[1,2,3]triazolo[4,5-h]quinazolin- 8-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine::US20230416271, Compound II.2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 US Patent 10.7270/Q2WS8ZF2 US20230416271 Cheng, H; Xiong, W; Niu, W; Yu, B; Jiang, Y Chengdu Cynogen Bio-Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642748&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167088653 488875593 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1362157 CC(C)n1nnc2ccc3cnc(N[C@H]4CC[C@@H](CC4)N4CCN(CC5CCCC5)CC4)nc3c12 InChI=1S/C27H40N8/c1-19(2)35-26-24(31-32-35)12-7-21-17-28-27(30-25(21)26)29-22-8-10-23(11-9-22)34-15-13-33(14-16-34)18-20-5-3-4-6-20/h7,12,17,19-20,22-23H,3-6,8-11,13-16,18H2,1-2H3,(H,28,29,30)/t22-,23- ZEWYBLWRWWDFIL-YHBQERECSA-N 642754 N-((1R,4R)-4-(4-(cyclopentylmethyl)piperazin-1-yl)cyclo- hexyl)-1-isopropyl-1H-[1,2,3]triazolo[4,5-h]quinazolin-8- amine::US20230416271, Compound II.8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2WS8ZF2 US20230416271 Cheng, H; Xiong, W; Niu, W; Yu, B; Jiang, Y Chengdu Cynogen Bio-Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642754&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167088683 488875599 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415399 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OCC3CCCC3O)n2)cc1 InChI=1S/C17H19N5O4S/c18-8-12-9-20-17(21-13-4-6-14(7-5-13)27(19,24)25)22-16(12)26-10-11-2-1-3-15(11)23/h4-7,9,11,15,23H,1-3,10H2,(H2,19,24,25)(H,20,21,22) IWWGENVVEPICMF-UHFFFAOYSA-N 676260 US20240166635, Example 19a::US20240166635, Example 19b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676260&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090242 500592025 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415405 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H17N5O4S/c17-8-10-9-19-16(21-15(10)25-14-3-1-2-13(14)22)20-11-4-6-12(7-5-11)26(18,23)24/h4-7,9,13-14,22H,1-3H2,(H2,18,23,24)(H,19,20,21) BFTPBRJJWBLTEE-UHFFFAOYSA-N 676262 US20240166635, Example 20a::US20240166635, Example 20b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676262&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171582037 500592026 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415411 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H17N5O4S/c17-8-10-9-19-16(21-15(10)25-14-3-1-2-13(14)22)20-11-4-6-12(7-5-11)26(18,23)24/h4-7,9,13-14,22H,1-3H2,(H2,18,23,24)(H,19,20,21) BFTPBRJJWBLTEE-UHFFFAOYSA-N 676262 US20240166635, Example 20a::US20240166635, Example 20b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676262&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171582037 500592026 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415414 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC(O)C3)n2)cc1 InChI=1S/C17H19N5O4S/c18-9-11-10-20-17(21-12-4-6-15(7-5-12)27(19,24)25)22-16(11)26-14-3-1-2-13(23)8-14/h4-7,10,13-14,23H,1-3,8H2,(H2,19,24,25)(H,20,21,22) ZYLLZJSOJVDLHC-UHFFFAOYSA-N 676264 US20240166635, Example 21a::US20240166635, Example 21b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090312 500592027 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415417 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC(O)C3)n2)cc1 InChI=1S/C17H19N5O4S/c18-9-11-10-20-17(21-12-4-6-15(7-5-12)27(19,24)25)22-16(11)26-14-3-1-2-13(23)8-14/h4-7,10,13-14,23H,1-3,8H2,(H2,19,24,25)(H,20,21,22) ZYLLZJSOJVDLHC-UHFFFAOYSA-N 676264 US20240166635, Example 21a::US20240166635, Example 21b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676264&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090312 500592027 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415423 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCCCC3O)n2)cc1 InChI=1S/C18H21N5O4S/c19-10-12-11-21-18(22-13-6-8-14(9-7-13)28(20,25)26)23-17(12)27-16-5-3-1-2-4-15(16)24/h6-9,11,15-16,24H,1-5H2,(H2,20,25,26)(H,21,22,23) ITGDXSWIUCVGDW-UHFFFAOYSA-N 676268 US20240166635, Example 22a::US20240166635, Example 22b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676268&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090133 500592029 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415426 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCCCC3O)n2)cc1 InChI=1S/C18H21N5O4S/c19-10-12-11-21-18(22-13-6-8-14(9-7-13)28(20,25)26)23-17(12)27-16-5-3-1-2-4-15(16)24/h6-9,11,15-16,24H,1-5H2,(H2,20,25,26)(H,21,22,23) ITGDXSWIUCVGDW-UHFFFAOYSA-N 676268 US20240166635, Example 22a::US20240166635, Example 22b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676268&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090133 500592029 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415432 CC1(O)CCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H19N5O4S/c1-17(23)8-2-3-14(17)26-15-11(9-18)10-20-16(22-15)21-12-4-6-13(7-5-12)27(19,24)25/h4-7,10,14,23H,2-3,8H2,1H3,(H2,19,24,25)(H,20,21,22) VBLLOFSUFOWCAN-UHFFFAOYSA-N 676270 US20240166635, Example 23a::US20240166635, Example 23b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676270&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090136 500592030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415435 CC1(O)CCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H19N5O4S/c1-17(23)8-2-3-14(17)26-15-11(9-18)10-20-16(22-15)21-12-4-6-13(7-5-12)27(19,24)25/h4-7,10,14,23H,2-3,8H2,1H3,(H2,19,24,25)(H,20,21,22) VBLLOFSUFOWCAN-UHFFFAOYSA-N 676270 US20240166635, Example 23a::US20240166635, Example 23b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676270&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090136 500592030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415441 CC1(O)CCCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C18H21N5O4S/c1-18(24)9-3-2-4-15(18)27-16-12(10-19)11-21-17(23-16)22-13-5-7-14(8-6-13)28(20,25)26/h5-8,11,15,24H,2-4,9H2,1H3,(H2,20,25,26)(H,21,22,23) DIWKEQSDYXLOJZ-UHFFFAOYSA-N 676276 US20240166635, Example 24a::US20240166635, Example 24b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676276&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089958 500592035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416102 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C18H21F3N4O4S/c19-18(20,21)13-10-23-17(24-11-6-8-12(9-7-11)30(22,27)28)25-16(13)29-15-5-3-1-2-4-14(15)26/h6-10,14-15,26H,1-5H2,(H2,22,27,28)(H,23,24,25) BHEVXPKVRPTJTA-UHFFFAOYSA-N 676418 US20240166635, Example 118a::US20240166635, Example 118b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens <10 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676418&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090127 500592135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416105 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C18H21F3N4O4S/c19-18(20,21)13-10-23-17(24-11-6-8-12(9-7-11)30(22,27)28)25-16(13)29-15-5-3-1-2-4-14(15)26/h6-10,14-15,26H,1-5H2,(H2,22,27,28)(H,23,24,25) BHEVXPKVRPTJTA-UHFFFAOYSA-N 676418 US20240166635, Example 118a::US20240166635, Example 118b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676418&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090127 500592135 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416111 CS(=O)(=O)C1CCC(CC1)Nc1ncc(c(OC2CCCC2O)n1)C(F)(F)F InChI=1S/C17H24F3N3O4S/c1-28(25,26)11-7-5-10(6-8-11)22-16-21-9-12(17(18,19)20)15(23-16)27-14-4-2-3-13(14)24/h9-11,13-14,24H,2-8H2,1H3,(H,21,22,23) KTSBBQZIUKTLBK-UHFFFAOYSA-N 676420 US20240166635, Example 119a::US20240166635, Example 119b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581948 500592136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416117 CS(=O)(=O)C1CCC(CC1)Nc1ncc(c(OC2CCCC2O)n1)C(F)(F)F InChI=1S/C17H24F3N3O4S/c1-28(25,26)11-7-5-10(6-8-11)22-16-21-9-12(17(18,19)20)15(23-16)27-14-4-2-3-13(14)24/h9-11,13-14,24H,2-8H2,1H3,(H,21,22,23) KTSBBQZIUKTLBK-UHFFFAOYSA-N 676420 US20240166635, Example 119a::US20240166635, Example 119b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676420&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581948 500592136 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416123 CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCC2O)n1)C(F)(F)F InChI=1S/C17H25F3N4O4S/c1-29(26,27)24-8-6-11(7-9-24)22-16-21-10-12(17(18,19)20)15(23-16)28-14-5-3-2-4-13(14)25/h10-11,13-14,25H,2-9H2,1H3,(H,21,22,23) LLJFUISHLUDNSH-UHFFFAOYSA-N 676422 US20240166635, Example 120a::US20240166635, Example 120b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676422&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090158 500592137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416126 CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCC2O)n1)C(F)(F)F InChI=1S/C17H25F3N4O4S/c1-29(26,27)24-8-6-11(7-9-24)22-16-21-10-12(17(18,19)20)15(23-16)28-14-5-3-2-4-13(14)25/h10-11,13-14,25H,2-9H2,1H3,(H,21,22,23) LLJFUISHLUDNSH-UHFFFAOYSA-N 676422 US20240166635, Example 120a::US20240166635, Example 120b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676422&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090158 500592137 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416132 CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2O)n1)C(F)(F)F InChI=1S/C18H27F3N4O4S/c1-30(27,28)25-9-7-12(8-10-25)23-17-22-11-13(18(19,20)21)16(24-17)29-15-6-4-2-3-5-14(15)26/h11-12,14-15,26H,2-10H2,1H3,(H,22,23,24) ITKOZHPPZHBFOM-UHFFFAOYSA-N 676424 US20240166635, Example 121a::US20240166635, Example 121b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676424&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090100 500592138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416135 CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2O)n1)C(F)(F)F InChI=1S/C18H27F3N4O4S/c1-30(27,28)25-9-7-12(8-10-25)23-17-22-11-13(18(19,20)21)16(24-17)29-15-6-4-2-3-5-14(15)26/h11-12,14-15,26H,2-10H2,1H3,(H,22,23,24) ITKOZHPPZHBFOM-UHFFFAOYSA-N 676424 US20240166635, Example 121a::US20240166635, Example 121b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676424&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090100 500592138 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416138 NS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2O)n1)C(F)(F)F InChI=1S/C17H26F3N5O4S/c18-17(19,20)12-10-22-16(23-11-6-8-25(9-7-11)30(21,27)28)24-15(12)29-14-5-3-1-2-4-13(14)26/h10-11,13-14,26H,1-9H2,(H2,21,27,28)(H,22,23,24) LJAFGINNHCYOKR-UHFFFAOYSA-N 676426 US20240166635, Example 122a::US20240166635, Example 122b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090101 500592139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415444 CC1(O)CCCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C18H21N5O4S/c1-18(24)9-3-2-4-15(18)27-16-12(10-19)11-21-17(23-16)22-13-5-7-14(8-6-13)28(20,25)26/h5-8,11,15,24H,2-4,9H2,1H3,(H2,20,25,26)(H,21,22,23) DIWKEQSDYXLOJZ-UHFFFAOYSA-N 676276 US20240166635, Example 24a::US20240166635, Example 24b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676276&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089958 500592035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415450 O[C@@H]1CCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CCC2)ncc1C#N InChI=1S/C20H23N5O4S/c21-11-13-12-22-20(24-19(13)29-18-6-2-5-17(18)26)23-14-7-9-16(10-8-14)30(27,28)25-15-3-1-4-15/h7-10,12,15,17-18,25-26H,1-6H2,(H,22,23,24)/t17-,18?/m1/s1 CPYMMHGVBXHMBP-QNSVNVJESA-N 676278 US20240166635, Example 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676278&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089959 500592036 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415456 CNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCC[C@H]3O)n2)cc1 InChI=1S/C17H19N5O4S/c1-19-27(24,25)13-7-5-12(6-8-13)21-17-20-10-11(9-18)16(22-17)26-15-4-2-3-14(15)23/h5-8,10,14-15,19,23H,2-4H2,1H3,(H,20,21,22)/t14-,15?/m1/s1 HCBVVIFOIUAUCN-GICMACPYSA-N 676279 US20240166635, Example 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676279&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090307 500592037 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415462 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCC[C@H]3O)n2)cc1 InChI=1S/C19H23N5O4S/c1-12(2)24-29(26,27)15-8-6-14(7-9-15)22-19-21-11-13(10-20)18(23-19)28-17-5-3-4-16(17)25/h6-9,11-12,16-17,24-25H,3-5H2,1-2H3,(H,21,22,23)/t16-,17?/m1/s1 ROCHEUVEICUFRE-TZHYSIJRSA-N 676281 US20240166635, Example 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676281&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090302 500592039 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415465 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3)n2)cc1 InChI=1S/C19H23N5O3S/c1-13(2)24-28(25,26)17-9-7-15(8-10-17)22-19-21-12-14(11-20)18(23-19)27-16-5-3-4-6-16/h7-10,12-13,16,24H,3-6H2,1-2H3,(H,21,22,23) CCZOOXOGXSHJDS-UHFFFAOYSA-N 676282 US20240166635, Example 28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676282&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169915536 500592040 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415468 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCC(O)C3)n2)cc1 InChI=1S/C19H23N5O4S/c1-12(2)24-29(26,27)17-7-3-14(4-8-17)22-19-21-11-13(10-20)18(23-19)28-16-6-5-15(25)9-16/h3-4,7-8,11-12,15-16,24-25H,5-6,9H2,1-2H3,(H,21,22,23) JDSITLRXOPSRTI-UHFFFAOYSA-N 676283 US20240166635, Example 29a::US20240166635, Example 29b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676283&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090348 500592041 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415471 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCC(O)C3)n2)cc1 InChI=1S/C19H23N5O4S/c1-12(2)24-29(26,27)17-7-3-14(4-8-17)22-19-21-11-13(10-20)18(23-19)28-16-6-5-15(25)9-16/h3-4,7-8,11-12,15-16,24-25H,5-6,9H2,1-2H3,(H,21,22,23) JDSITLRXOPSRTI-UHFFFAOYSA-N 676283 US20240166635, Example 29a::US20240166635, Example 29b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676283&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090348 500592041 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415474 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCCC3O)n2)cc1 InChI=1S/C20H25N5O4S/c1-13(2)25-30(27,28)16-9-7-15(8-10-16)23-20-22-12-14(11-21)19(24-20)29-18-6-4-3-5-17(18)26/h7-10,12-13,17-18,25-26H,3-6H2,1-2H3,(H,22,23,24) FUOODLXHHHSFFE-UHFFFAOYSA-N 676285 US20240166635, Example 30a::US20240166635, Example 30b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676285&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090203 500592042 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415477 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCCC3O)n2)cc1 InChI=1S/C20H25N5O4S/c1-13(2)25-30(27,28)16-9-7-15(8-10-16)23-20-22-12-14(11-21)19(24-20)29-18-6-4-3-5-17(18)26/h7-10,12-13,17-18,25-26H,3-6H2,1-2H3,(H,22,23,24) FUOODLXHHHSFFE-UHFFFAOYSA-N 676285 US20240166635, Example 30a::US20240166635, Example 30b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676285&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090203 500592042 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415483 OC1CCCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2C[C@H](F)C2)ncc1C#N InChI=1S/C21H24FN5O4S/c22-14-9-16(10-14)27-32(29,30)17-7-5-15(6-8-17)25-21-24-12-13(11-23)20(26-21)31-19-4-2-1-3-18(19)28/h5-8,12,14,16,18-19,27-28H,1-4,9-10H2,(H,24,25,26)/t14-,16?,18?,19? XSIFVBNGGAAWSP-MPCHACMSSA-N 676287 US20240166635, Example 31a::US20240166635, Example 31b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676287&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990654 500592043 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415486 OC1CCCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2C[C@H](F)C2)ncc1C#N InChI=1S/C21H24FN5O4S/c22-14-9-16(10-14)27-32(29,30)17-7-5-15(6-8-17)25-21-24-12-13(11-23)20(26-21)31-19-4-2-1-3-18(19)28/h5-8,12,14,16,18-19,27-28H,1-4,9-10H2,(H,24,25,26)/t14-,16?,18?,19? XSIFVBNGGAAWSP-MPCHACMSSA-N 676287 US20240166635, Example 31a::US20240166635, Example 31b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676287&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990654 500592043 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416144 NS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2O)n1)C(F)(F)F InChI=1S/C17H26F3N5O4S/c18-17(19,20)12-10-22-16(23-11-6-8-25(9-7-11)30(21,27)28)24-15(12)29-14-5-3-1-2-4-13(14)26/h10-11,13-14,26H,1-9H2,(H2,21,27,28)(H,22,23,24) LJAFGINNHCYOKR-UHFFFAOYSA-N 676426 US20240166635, Example 122a::US20240166635, Example 122b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676426&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090101 500592139 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416147 CNS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2O)n1)C(F)(F)F InChI=1S/C18H28F3N5O4S/c1-22-31(28,29)26-9-7-12(8-10-26)24-17-23-11-13(18(19,20)21)16(25-17)30-15-6-4-2-3-5-14(15)27/h11-12,14-15,22,27H,2-10H2,1H3,(H,23,24,25) LNWDZMBWOAKXFT-UHFFFAOYSA-N 676428 US20240166635, Example 123a::US20240166635, Example 123b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676428&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089970 500592140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416153 CNS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2O)n1)C(F)(F)F InChI=1S/C18H28F3N5O4S/c1-22-31(28,29)26-9-7-12(8-10-26)24-17-23-11-13(18(19,20)21)16(25-17)30-15-6-4-2-3-5-14(15)27/h11-12,14-15,22,27H,2-10H2,1H3,(H,23,24,25) LNWDZMBWOAKXFT-UHFFFAOYSA-N 676428 US20240166635, Example 123a::US20240166635, Example 123b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676428&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089970 500592140 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416159 CC1(O)COCCC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C(F)(F)F InChI=1S/C17H25F3N4O5S/c1-16(25)10-28-8-5-13(16)29-14-12(17(18,19)20)9-21-15(23-14)22-11-3-6-24(7-4-11)30(2,26)27/h9,11,13,25H,3-8,10H2,1-2H3,(H,21,22,23) MGXMGVUPCOMEOS-UHFFFAOYSA-N 676430 US20240166635, Example 124a::US20240166635, Example 124b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676430&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090359 500592141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416164 CC1(O)COCCC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C(F)(F)F InChI=1S/C17H25F3N4O5S/c1-16(25)10-28-8-5-13(16)29-14-12(17(18,19)20)9-21-15(23-14)22-11-3-6-24(7-4-11)30(2,26)27/h9,11,13,25H,3-8,10H2,1-2H3,(H,21,22,23) MGXMGVUPCOMEOS-UHFFFAOYSA-N 676430 US20240166635, Example 124a::US20240166635, Example 124b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676430&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090359 500592141 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416170 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCOCC2(C)O)n1)C(F)(F)F InChI=1S/C20H27F3N6O5S/c1-19(30)12-33-8-5-16(19)34-17-15(20(21,22)23)10-24-18(27-17)26-13-3-6-29(7-4-13)35(31,32)14-9-25-28(2)11-14/h9-11,13,16,30H,3-8,12H2,1-2H3,(H,24,26,27) KXDROPRNEYFQHH-UHFFFAOYSA-N 676432 US20240166635, Example 125a::US20240166635, Example 125b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676432&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090017 500592142 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416180 CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCC2)n1)C(F)(F)F InChI=1S/C15H21F3N4O3S/c1-26(23,24)22-7-5-10(6-8-22)20-14-19-9-12(15(16,17)18)13(21-14)25-11-3-2-4-11/h9-11H,2-8H2,1H3,(H,19,20,21) PURBWBJEHYPPFZ-UHFFFAOYSA-N 676434 US20240166635, Example 126 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676434&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090223 500592143 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416186 CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCC2)n1)C(F)(F)F InChI=1S/C17H25F3N4O3S/c1-28(25,26)24-9-7-12(8-10-24)22-16-21-11-14(17(18,19)20)15(23-16)27-13-5-3-2-4-6-13/h11-13H,2-10H2,1H3,(H,21,22,23) SXBXSQCRXJFCCE-UHFFFAOYSA-N 676435 US20240166635, Example 127 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676435&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090220 500592144 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415492 OC1CCCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CC(F)C2)ncc1C#N InChI=1S/C21H24FN5O4S/c22-14-9-16(10-14)27-32(29,30)17-7-5-15(6-8-17)25-21-24-12-13(11-23)20(26-21)31-19-4-2-1-3-18(19)28/h5-8,12,14,16,18-19,27-28H,1-4,9-10H2,(H,24,25,26) XSIFVBNGGAAWSP-UHFFFAOYSA-N 676289 US20240166635, Example 32a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676289&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990654 500592044 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415495 OC1CCCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CC(F)(F)C2)ncc1C#N InChI=1S/C21H23F2N5O4S/c22-21(23)9-15(10-21)28-33(30,31)16-7-5-14(6-8-16)26-20-25-12-13(11-24)19(27-20)32-18-4-2-1-3-17(18)29/h5-8,12,15,17-18,28-29H,1-4,9-10H2,(H,25,26,27) FXGNWCXJPANYOD-UHFFFAOYSA-N 676290 US20240166635, Example 32b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676290&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090138 500592045 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415501 CNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCOCC3)n2)cc1 InChI=1S/C18H21N5O4S/c1-20-28(24,25)16-6-4-14(5-7-16)22-18-21-12-13(11-19)17(23-18)27-15-3-2-9-26-10-8-15/h4-7,12,15,20H,2-3,8-10H2,1H3,(H,21,22,23) LYXRABIWUDHHOT-UHFFFAOYSA-N 676291 US20240166635, Example 33a::US20240166635, Example 33b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676291&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990655 500592046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415504 CNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCOCC3)n2)cc1 InChI=1S/C18H21N5O4S/c1-20-28(24,25)16-6-4-14(5-7-16)22-18-21-12-13(11-19)17(23-18)27-15-3-2-9-26-10-8-15/h4-7,12,15,20H,2-3,8-10H2,1H3,(H,21,22,23) LYXRABIWUDHHOT-UHFFFAOYSA-N 676291 US20240166635, Example 33a::US20240166635, Example 33b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676291&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990655 500592046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415510 CNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3(C)O)n2)cc1 InChI=1S/C18H21N5O4S/c1-18(24)9-3-4-15(18)27-16-12(10-19)11-21-17(23-16)22-13-5-7-14(8-6-13)28(25,26)20-2/h5-8,11,15,20,24H,3-4,9H2,1-2H3,(H,21,22,23) QMXSDPDZRQFBHB-UHFFFAOYSA-N 676293 US20240166635, Example 34a::US20240166635, Example 34b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676293&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090173 500592047 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415513 CNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3(C)O)n2)cc1 InChI=1S/C18H21N5O4S/c1-18(24)9-3-4-15(18)27-16-12(10-19)11-21-17(23-16)22-13-5-7-14(8-6-13)28(25,26)20-2/h5-8,11,15,20,24H,3-4,9H2,1-2H3,(H,21,22,23) QMXSDPDZRQFBHB-UHFFFAOYSA-N 676293 US20240166635, Example 34a::US20240166635, Example 34b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676293&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090173 500592047 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415519 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3(C)O)n2)cc1 InChI=1S/C20H25N5O4S/c1-13(2)25-30(27,28)16-8-6-15(7-9-16)23-19-22-12-14(11-21)18(24-19)29-17-5-4-10-20(17,3)26/h6-9,12-13,17,25-26H,4-5,10H2,1-3H3,(H,22,23,24) KGLRDVBOUHMCJQ-UHFFFAOYSA-N 676295 US20240166635, Example 35a::US20240166635, Example 35b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676295&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089955 500592048 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415522 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3(C)O)n2)cc1 InChI=1S/C20H25N5O4S/c1-13(2)25-30(27,28)16-8-6-15(7-9-16)23-19-22-12-14(11-21)18(24-19)29-17-5-4-10-20(17,3)26/h6-9,12-13,17,25-26H,4-5,10H2,1-3H3,(H,22,23,24) KGLRDVBOUHMCJQ-UHFFFAOYSA-N 676295 US20240166635, Example 35a::US20240166635, Example 35b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676295&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089955 500592048 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415525 CCS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C18H27N5O4S/c1-3-28(25,26)23-9-6-14(7-10-23)21-17-20-12-13(11-19)16(22-17)27-15-5-4-8-18(15,2)24/h12,14-15,24H,3-10H2,1-2H3,(H,20,21,22) YOHCMXQAXUTESC-UHFFFAOYSA-N 676297 US20240166635, Example 36a::US20240166635, Example 36b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676297&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090011 500592049 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415531 CCS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C18H27N5O4S/c1-3-28(25,26)23-9-6-14(7-10-23)21-17-20-12-13(11-19)16(22-17)27-15-5-4-8-18(15,2)24/h12,14-15,24H,3-10H2,1-2H3,(H,20,21,22) YOHCMXQAXUTESC-UHFFFAOYSA-N 676297 US20240166635, Example 36a::US20240166635, Example 36b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676297&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090011 500592049 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416192 CC1(COc2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2C(F)(F)F)CCCC1 InChI=1S/C18H27F3N4O3S/c1-17(7-3-4-8-17)12-28-15-14(18(19,20)21)11-22-16(24-15)23-13-5-9-25(10-6-13)29(2,26)27/h11,13H,3-10,12H2,1-2H3,(H,22,23,24) PFPUFIQGDNYBND-UHFFFAOYSA-N 676436 US20240166635, Example 128 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676436&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090222 500592145 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416198 CNS(=O)(=O)N1CCC(CC1)Nc1ncc(c(OC2CCCCCC2)n1)C(F)(F)F InChI=1S/C18H28F3N5O3S/c1-22-30(27,28)26-10-8-13(9-11-26)24-17-23-12-15(18(19,20)21)16(25-17)29-14-6-4-2-3-5-7-14/h12-14,22H,2-11H2,1H3,(H,23,24,25) CXABQNFLIBANJT-UHFFFAOYSA-N 676437 US20240166635, Example 129 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676437&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090107 500592146 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416204 O[C@@H]1CCC[C@@H]1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CCOCC2)ncc1Cl InChI=1S/C20H25ClN4O5S/c21-16-12-22-20(24-19(16)30-18-3-1-2-17(18)26)23-13-4-6-15(7-5-13)31(27,28)25-14-8-10-29-11-9-14/h4-7,12,14,17-18,25-26H,1-3,8-11H2,(H,22,23,24)/t17-,18+/m1/s1 VRFZDEOOGRCBHS-MSOLQXFVSA-N 676438 US20240166635, Example 130a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676438&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090076 500592147 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416207 O[C@@H]1CCC[C@H]1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CCOCC2)ncc1Cl InChI=1S/C20H25ClN4O5S/c21-16-12-22-20(24-19(16)30-18-3-1-2-17(18)26)23-13-4-6-15(7-5-13)31(27,28)25-14-8-10-29-11-9-14/h4-7,12,14,17-18,25-26H,1-3,8-11H2,(H,22,23,24)/t17-,18-/m1/s1 VRFZDEOOGRCBHS-QZTJIDSGSA-N 676439 US20240166635, Example 130b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676439&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990667 500592148 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416213 CC1(COC1)NS(=O)(=O)c1ccc(Nc2ncc(Br)c(O[C@H]3CCC[C@H]3O)n2)cc1 InChI=1S/C19H23BrN4O5S/c1-19(10-28-11-19)24-30(26,27)13-7-5-12(6-8-13)22-18-21-9-14(20)17(23-18)29-16-4-2-3-15(16)25/h5-9,15-16,24-25H,2-4,10-11H2,1H3,(H,21,22,23)/t15-,16+/m1/s1 UPTWBJNAWIDIOT-CVEARBPZSA-N 676440 US20240166635, Example 131a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676440&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090230 500592149 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416216 CC1(COC1)NS(=O)(=O)c1ccc(Nc2ncc(Br)c(O[C@@H]3CCC[C@H]3O)n2)cc1 InChI=1S/C19H23BrN4O5S/c1-19(10-28-11-19)24-30(26,27)13-7-5-12(6-8-13)22-18-21-9-14(20)17(23-18)29-16-4-2-3-15(16)25/h5-9,15-16,24-25H,2-4,10-11H2,1H3,(H,21,22,23)/t15-,16-/m1/s1 UPTWBJNAWIDIOT-HZPDHXFCSA-N 676441 US20240166635, Example 131b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676441&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990668 500592150 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416222 Cc1cnc(Nc2ccc(cc2)S(N)(=O)=O)nc1O[C@H]1CCC[C@H]1O InChI=1S/C16H20N4O4S/c1-10-9-18-16(20-15(10)24-14-4-2-3-13(14)21)19-11-5-7-12(8-6-11)25(17,22)23/h5-9,13-14,21H,2-4H2,1H3,(H2,17,22,23)(H,18,19,20)/t13-,14+/m1/s1 UGHLOFSFUSXPNA-KGLIPLIRSA-N 676442 US20240166635, Example 132a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676442&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089951 500592151 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416225 Cc1cnc(Nc2ccc(cc2)S(N)(=O)=O)nc1O[C@@H]1CCC[C@H]1O InChI=1S/C16H20N4O4S/c1-10-9-18-16(20-15(10)24-14-4-2-3-13(14)21)19-11-5-7-12(8-6-11)25(17,22)23/h5-9,13-14,21H,2-4H2,1H3,(H2,17,22,23)(H,18,19,20)/t13-,14-/m1/s1 UGHLOFSFUSXPNA-ZIAGYGMSSA-N 676443 US20240166635, Example 132b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676443&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990669 500592152 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416231 CCc1cnc(Nc2ccc(cc2)S(N)(=O)=O)nc1O[C@H]1CCC[C@H]1O InChI=1S/C17H22N4O4S/c1-2-11-10-19-17(21-16(11)25-15-5-3-4-14(15)22)20-12-6-8-13(9-7-12)26(18,23)24/h6-10,14-15,22H,2-5H2,1H3,(H2,18,23,24)(H,19,20,21)/t14-,15+/m1/s1 JADLERCCPNPQHG-CABCVRRESA-N 676444 US20240166635, Example 133a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676444&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090028 500592153 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415537 CC1(O)CCCC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CF)ncc1C#N InChI=1S/C17H24FN5O4S/c1-17(24)6-2-3-14(17)27-15-12(9-19)10-20-16(22-15)21-13-4-7-23(8-5-13)28(25,26)11-18/h10,13-14,24H,2-8,11H2,1H3,(H,20,21,22) IVURPCHRYKNZNK-UHFFFAOYSA-N 676299 US20240166635, Example 37a::US20240166635, Example 37b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090012 500592050 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415540 CC1(O)CCCC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CF)ncc1C#N InChI=1S/C17H24FN5O4S/c1-17(24)6-2-3-14(17)27-15-12(9-19)10-20-16(22-15)21-13-4-7-23(8-5-13)28(25,26)11-18/h10,13-14,24H,2-8,11H2,1H3,(H,20,21,22) IVURPCHRYKNZNK-UHFFFAOYSA-N 676299 US20240166635, Example 37a::US20240166635, Example 37b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676299&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090012 500592050 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415546 CC1(O)CCCC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CC2CC2)ncc1C#N InChI=1S/C20H29N5O4S/c1-20(26)8-2-3-17(20)29-18-15(11-21)12-22-19(24-18)23-16-6-9-25(10-7-16)30(27,28)13-14-4-5-14/h12,14,16-17,26H,2-10,13H2,1H3,(H,22,23,24) RFQTYMYGZAUINI-UHFFFAOYSA-N 676301 US20240166635, Example 38a::US20240166635, Example 38b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676301&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090103 500592051 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415549 CC1(O)CCCC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CC2CC2)ncc1C#N InChI=1S/C20H29N5O4S/c1-20(26)8-2-3-17(20)29-18-15(11-21)12-22-19(24-18)23-16-6-9-25(10-7-16)30(27,28)13-14-4-5-14/h12,14,16-17,26H,2-10,13H2,1H3,(H,22,23,24) RFQTYMYGZAUINI-UHFFFAOYSA-N 676301 US20240166635, Example 38a::US20240166635, Example 38b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676301&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090103 500592051 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415555 CC(C)CS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C20H31N5O4S/c1-14(2)13-30(27,28)25-9-6-16(7-10-25)23-19-22-12-15(11-21)18(24-19)29-17-5-4-8-20(17,3)26/h12,14,16-17,26H,4-10,13H2,1-3H3,(H,22,23,24) MTDAFJHVIZBORH-UHFFFAOYSA-N 676303 US20240166635, Example 39a::US20240166635, Example 39b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676303&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171582096 500592052 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415558 CC(C)CS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C20H31N5O4S/c1-14(2)13-30(27,28)25-9-6-16(7-10-25)23-19-22-12-15(11-21)18(24-19)29-17-5-4-8-20(17,3)26/h12,14,16-17,26H,4-10,13H2,1-3H3,(H,22,23,24) MTDAFJHVIZBORH-UHFFFAOYSA-N 676303 US20240166635, Example 39a::US20240166635, Example 39b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676303&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171582096 500592052 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415564 CC1(O)CCCC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CC2CCOC2)ncc1C#N InChI=1S/C21H31N5O5S/c1-21(27)7-2-3-18(21)31-19-16(11-22)12-23-20(25-19)24-17-4-8-26(9-5-17)32(28,29)14-15-6-10-30-13-15/h12,15,17-18,27H,2-10,13-14H2,1H3,(H,23,24,25) KBKJXHHYCYMRHQ-UHFFFAOYSA-N 676305 US20240166635, Example 40a::US20240166635, Example 40b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676305&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090175 500592053 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415574 COCCS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C19H29N5O5S/c1-19(25)7-3-4-16(19)29-17-14(12-20)13-21-18(23-17)22-15-5-8-24(9-6-15)30(26,27)11-10-28-2/h13,15-16,25H,3-11H2,1-2H3,(H,21,22,23) WNPAEAQXLNHGQL-UHFFFAOYSA-N 676307 US20240166635, Example 41a::US20240166635, Example 41b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676307&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090099 500592054 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416234 CCc1cnc(Nc2ccc(cc2)S(N)(=O)=O)nc1O[C@@H]1CCC[C@H]1O InChI=1S/C17H22N4O4S/c1-2-11-10-19-17(21-16(11)25-15-5-3-4-14(15)22)20-12-6-8-13(9-7-12)26(18,23)24/h6-10,14-15,22H,2-5H2,1H3,(H2,18,23,24)(H,19,20,21)/t14-,15-/m1/s1 JADLERCCPNPQHG-HUUCEWRRSA-N 676445 US20240166635, Example 133b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676445&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990670 500592154 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416240 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C3CC3)c(O[C@H]3CCC[C@H]3O)n2)cc1 InChI=1S/C21H28N4O4S/c1-13(2)25-30(27,28)16-10-8-15(9-11-16)23-21-22-12-17(14-6-7-14)20(24-21)29-19-5-3-4-18(19)26/h8-14,18-19,25-26H,3-7H2,1-2H3,(H,22,23,24)/t18-,19+/m1/s1 RXQUQZRKAFSXQT-MOPGFXCFSA-N 676446 US20240166635, Example 134a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676446&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169915556 500592155 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416243 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C3CC3)c(O[C@@H]3CCC[C@H]3O)n2)cc1 InChI=1S/C21H28N4O4S/c1-13(2)25-30(27,28)16-10-8-15(9-11-16)23-21-22-12-17(14-6-7-14)20(24-21)29-19-5-3-4-18(19)26/h8-14,18-19,25-26H,3-7H2,1-2H3,(H,22,23,24)/t18-,19-/m1/s1 RXQUQZRKAFSXQT-RTBURBONSA-N 676447 US20240166635, Example 134b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676447&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990671 500592156 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416249 CNS(=O)(=O)c1ccc(Nc2ncc(C(F)=C)c(O[C@H]3CCC[C@H]3O)n2)cc1 InChI=1S/C18H21FN4O4S/c1-11(19)14-10-21-18(23-17(14)27-16-5-3-4-15(16)24)22-12-6-8-13(9-7-12)28(25,26)20-2/h6-10,15-16,20,24H,1,3-5H2,2H3,(H,21,22,23)/t15-,16+/m1/s1 QXSFFHMNHMKKGS-CVEARBPZSA-N 676448 US20240166635, Example 135a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676448&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990672 500592157 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416252 CNS(=O)(=O)c1ccc(Nc2ncc(C(F)=C)c(O[C@@H]3CCC[C@H]3O)n2)cc1 InChI=1S/C18H21FN4O4S/c1-11(19)14-10-21-18(23-17(14)27-16-5-3-4-15(16)24)22-12-6-8-13(9-7-12)28(25,26)20-2/h6-10,15-16,20,24H,1,3-5H2,2H3,(H,21,22,23)/t15-,16-/m1/s1 QXSFFHMNHMKKGS-HZPDHXFCSA-N 676449 US20240166635, Example 135b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676449&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990673 500592158 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416258 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O4S/c17-16(18,19)11-8-21-15(23-14(11)27-13-3-1-2-12(13)24)22-9-4-6-10(7-5-9)28(20,25)26/h4-8,12-13,24H,1-3H2,(H2,20,25,26)(H,21,22,23) ALDIKYMFXCVIAW-UHFFFAOYSA-N 676450 US20240166635, Example 136a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676450&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089954 500592159 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416261 NS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C15H17ClN4O4S/c16-11-8-18-15(20-14(11)24-13-3-1-2-12(13)21)19-9-4-6-10(7-5-9)25(17,22)23/h4-8,12-13,21H,1-3H2,(H2,17,22,23)(H,18,19,20) UBDZFVZGIHPXQL-UHFFFAOYSA-N 676451 US20240166635, Example 136b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676451&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090044 500592160 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416267 CNS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H19ClN4O4S/c1-18-26(23,24)11-7-5-10(6-8-11)20-16-19-9-12(17)15(21-16)25-14-4-2-3-13(14)22/h5-9,13-14,18,22H,2-4H2,1H3,(H,19,20,21) QWNPBVNMKNDQGI-UHFFFAOYSA-N 676452 US20240166635, Example 137a::US20240166635, Example 137b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676452&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090201 500592161 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416270 CNS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H19ClN4O4S/c1-18-26(23,24)11-7-5-10(6-8-11)20-16-19-9-12(17)15(21-16)25-14-4-2-3-13(14)22/h5-9,13-14,18,22H,2-4H2,1H3,(H,19,20,21) QWNPBVNMKNDQGI-UHFFFAOYSA-N 676452 US20240166635, Example 137a::US20240166635, Example 137b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676452&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090201 500592161 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415579 COCCS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C19H29N5O5S/c1-19(25)7-3-4-16(19)29-17-14(12-20)13-21-18(23-17)22-15-5-8-24(9-6-15)30(26,27)11-10-28-2/h13,15-16,25H,3-11H2,1-2H3,(H,21,22,23) WNPAEAQXLNHGQL-UHFFFAOYSA-N 676307 US20240166635, Example 41a::US20240166635, Example 41b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676307&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090099 500592054 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415593 CC1(O)CCCC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CC(F)(F)F)ncc1C#N InChI=1S/C18H24F3N5O4S/c1-17(27)6-2-3-14(17)30-15-12(9-22)10-23-16(25-15)24-13-4-7-26(8-5-13)31(28,29)11-18(19,20)21/h10,13-14,27H,2-8,11H2,1H3,(H,23,24,25) TXBBMRZBMVLLAQ-UHFFFAOYSA-N 676311 US20240166635, Example 43a::US20240166635, Example 43b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676311&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090053 500592056 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415602 CC1(O)CC(F)(F)CC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CC2CC2)ncc1C#N InChI=1S/C20H27F2N5O4S/c1-19(28)12-20(21,22)8-16(19)31-17-14(9-23)10-24-18(26-17)25-15-4-6-27(7-5-15)32(29,30)11-13-2-3-13/h10,13,15-16,28H,2-8,11-12H2,1H3,(H,24,25,26) UAAXTVOYMWPDBQ-UHFFFAOYSA-N 676313 US20240166635, Example 44a::US20240166635, Example 44b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676313&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090055 500592057 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415608 CC1(O)CC(F)(F)CC1Oc1nc(NC2CCN(CC2)S(=O)(=O)CC2CC2)ncc1C#N InChI=1S/C20H27F2N5O4S/c1-19(28)12-20(21,22)8-16(19)31-17-14(9-23)10-24-18(26-17)25-15-4-6-27(7-5-15)32(29,30)11-13-2-3-13/h10,13,15-16,28H,2-8,11-12H2,1H3,(H,24,25,26) UAAXTVOYMWPDBQ-UHFFFAOYSA-N 676313 US20240166635, Example 44a::US20240166635, Example 44b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676313&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090055 500592057 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415614 CC1(O)COCCC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H25N5O5S/c1-17(23)11-26-8-5-14(17)27-15-12(9-18)10-19-16(21-15)20-13-3-6-22(7-4-13)28(2,24)25/h10,13-14,23H,3-8,11H2,1-2H3,(H,19,20,21) KXJILSLZMSOTHK-UHFFFAOYSA-N 676315 US20240166635, Example 45a::US20240166635, Example 45b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676315&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090344 500592058 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415619 CC1(O)COCCC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H25N5O5S/c1-17(23)11-26-8-5-14(17)27-15-12(9-18)10-19-16(21-15)20-13-3-6-22(7-4-13)28(2,24)25/h10,13-14,23H,3-8,11H2,1-2H3,(H,19,20,21) KXJILSLZMSOTHK-UHFFFAOYSA-N 676315 US20240166635, Example 45a::US20240166635, Example 45b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676315&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090344 500592058 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416276 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C18H23ClN4O4S/c1-11(2)23-28(25,26)13-8-6-12(7-9-13)21-18-20-10-14(19)17(22-18)27-16-5-3-4-15(16)24/h6-11,15-16,23-24H,3-5H2,1-2H3,(H,20,21,22) PMWBBNBMWPQOEF-UHFFFAOYSA-N 676454 US20240166635, Example 138a::US20240166635, Example 138b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090010 500592162 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416279 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C18H23ClN4O4S/c1-11(2)23-28(25,26)13-8-6-12(7-9-13)21-18-20-10-14(19)17(22-18)27-16-5-3-4-15(16)24/h6-11,15-16,23-24H,3-5H2,1-2H3,(H,20,21,22) PMWBBNBMWPQOEF-UHFFFAOYSA-N 676454 US20240166635, Example 138a::US20240166635, Example 138b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676454&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090010 500592162 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416285 CN1CCC(CC1)NS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C21H28ClN5O4S/c1-27-11-9-15(10-12-27)26-32(29,30)16-7-5-14(6-8-16)24-21-23-13-17(22)20(25-21)31-19-4-2-3-18(19)28/h5-8,13,15,18-19,26,28H,2-4,9-12H2,1H3,(H,23,24,25) IXDIKQYUVPRTQH-UHFFFAOYSA-N 676456 US20240166635, Example 139a::US20240166635, Example 139b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090026 500592163 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416291 CN1CCC(CC1)NS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3CCCC3O)n2)cc1 InChI=1S/C21H28ClN5O4S/c1-27-11-9-15(10-12-27)26-32(29,30)16-7-5-14(6-8-16)24-21-23-13-17(22)20(25-21)31-19-4-2-3-18(19)28/h5-8,13,15,18-19,26,28H,2-4,9-12H2,1H3,(H,23,24,25) IXDIKQYUVPRTQH-UHFFFAOYSA-N 676456 US20240166635, Example 139a::US20240166635, Example 139b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676456&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090026 500592163 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416297 CNS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3COCC3(C)O)n2)cc1 InChI=1S/C16H19ClN4O5S/c1-16(22)9-25-8-13(16)26-14-12(17)7-19-15(21-14)20-10-3-5-11(6-4-10)27(23,24)18-2/h3-7,13,18,22H,8-9H2,1-2H3,(H,19,20,21) MCVYLHWRTAZNNE-UHFFFAOYSA-N 676458 US20240166635, Example 140a::US20240166635, Example 140b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990674 500592164 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416300 CNS(=O)(=O)c1ccc(Nc2ncc(Cl)c(OC3COCC3(C)O)n2)cc1 InChI=1S/C16H19ClN4O5S/c1-16(22)9-25-8-13(16)26-14-12(17)7-19-15(21-14)20-10-3-5-11(6-4-10)27(23,24)18-2/h3-7,13,18,22H,8-9H2,1-2H3,(H,19,20,21) MCVYLHWRTAZNNE-UHFFFAOYSA-N 676458 US20240166635, Example 140a::US20240166635, Example 140b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676458&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990674 500592164 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416306 NS(=O)(=O)c1ccc(Nc2ncc(Br)c(OC3CCCC3O)n2)cc1 InChI=1S/C15H17BrN4O4S/c16-11-8-18-15(20-14(11)24-13-3-1-2-12(13)21)19-9-4-6-10(7-5-9)25(17,22)23/h4-8,12-13,21H,1-3H2,(H2,17,22,23)(H,18,19,20) FPCYLEFUNFBEOV-UHFFFAOYSA-N 676460 US20240166635, Example 141a::US20240166635, Example 141b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090029 500592165 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416309 NS(=O)(=O)c1ccc(Nc2ncc(Br)c(OC3CCCC3O)n2)cc1 InChI=1S/C15H17BrN4O4S/c16-11-8-18-15(20-14(11)24-13-3-1-2-12(13)21)19-9-4-6-10(7-5-9)25(17,22)23/h4-8,12-13,21H,1-3H2,(H2,17,22,23)(H,18,19,20) FPCYLEFUNFBEOV-UHFFFAOYSA-N 676460 US20240166635, Example 141a::US20240166635, Example 141b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676460&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090029 500592165 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416315 CNS(=O)(=O)c1ccc(Nc2ncc(Br)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H19BrN4O4S/c1-18-26(23,24)11-7-5-10(6-8-11)20-16-19-9-12(17)15(21-16)25-14-4-2-3-13(14)22/h5-9,13-14,18,22H,2-4H2,1H3,(H,19,20,21) NHBKBNJTRGHNMQ-UHFFFAOYSA-N 676462 US20240166635, Example 142a::US20240166635, Example 142b::US20240166635, Example 143a::US20240166635, Example 143b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090250 500592166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416318 CNS(=O)(=O)c1ccc(Nc2ncc(Br)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H19BrN4O4S/c1-18-26(23,24)11-7-5-10(6-8-11)20-16-19-9-12(17)15(21-16)25-14-4-2-3-13(14)22/h5-9,13-14,18,22H,2-4H2,1H3,(H,19,20,21) NHBKBNJTRGHNMQ-UHFFFAOYSA-N 676462 US20240166635, Example 142a::US20240166635, Example 142b::US20240166635, Example 143a::US20240166635, Example 143b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090250 500592166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415628 CC1(O)CCC(F)(F)CC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C18H25F2N5O4S/c1-17(26)5-6-18(19,20)9-14(17)29-15-12(10-21)11-22-16(24-15)23-13-3-7-25(8-4-13)30(2,27)28/h11,13-14,26H,3-9H2,1-2H3,(H,22,23,24) YXQIJCZYWYSLMZ-UHFFFAOYSA-N 676317 US20240166635, Example 46a::US20240166635, Example 46b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676317&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090343 500592059 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415634 CC1(O)CC(F)(F)CCC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C18H25F2N5O4S/c1-17(26)11-18(19,20)6-3-14(17)29-15-12(9-21)10-22-16(24-15)23-13-4-7-25(8-5-13)30(2,27)28/h10,13-14,26H,3-8,11H2,1-2H3,(H,22,23,24) UAACCBHMQBQBIY-UHFFFAOYSA-N 676319 US20240166635, Example 47a::US20240166635, Example 47b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676319&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090342 500592060 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415640 CC1(O)CC(F)(F)CCC1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C18H25F2N5O4S/c1-17(26)11-18(19,20)6-3-14(17)29-15-12(9-21)10-22-16(24-15)23-13-4-7-25(8-5-13)30(2,27)28/h10,13-14,26H,3-8,11H2,1-2H3,(H,22,23,24) UAACCBHMQBQBIY-UHFFFAOYSA-N 676319 US20240166635, Example 47a::US20240166635, Example 47b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676319&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090342 500592060 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415646 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C20H27N7O4S/c1-20(28)7-3-4-17(20)31-18-14(10-21)11-22-19(25-18)24-15-5-8-27(9-6-15)32(29,30)16-12-23-26(2)13-16/h11-13,15,17,28H,3-9H2,1-2H3,(H,22,24,25) TYCIGEQMTDJQIM-UHFFFAOYSA-N 676321 US20240166635, Example 48a::US20240166635, Example 48b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676321&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090349 500592061 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415651 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C20H27N7O4S/c1-20(28)7-3-4-17(20)31-18-14(10-21)11-22-19(25-18)24-15-5-8-27(9-6-15)32(29,30)16-12-23-26(2)13-16/h11-13,15,17,28H,3-9H2,1-2H3,(H,22,24,25) TYCIGEQMTDJQIM-UHFFFAOYSA-N 676321 US20240166635, Example 48a::US20240166635, Example 48b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676321&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090349 500592061 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415657 Cn1cc(cn1)S(=O)(=O)N1CCC(Nc2ncc(C#N)c(OC3CCCC3(C)O)n2)C(F)C1 InChI=1S/C20H26FN7O4S/c1-20(29)6-3-4-17(20)32-18-13(8-22)9-23-19(26-18)25-16-5-7-28(12-15(16)21)33(30,31)14-10-24-27(2)11-14/h9-11,15-17,29H,3-7,12H2,1-2H3,(H,23,25,26) AIPDCXCWEXJHRH-UHFFFAOYSA-N 676323 US20240166635, Example 49a::US20240166635, Example 49b::US20240166635, Example 49c::US20240166635, Example 49d Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676323&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090234 500592062 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416324 CNS(=O)(=O)c1ccc(Nc2ncc(Br)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H19BrN4O4S/c1-18-26(23,24)11-7-5-10(6-8-11)20-16-19-9-12(17)15(21-16)25-14-4-2-3-13(14)22/h5-9,13-14,18,22H,2-4H2,1H3,(H,19,20,21) NHBKBNJTRGHNMQ-UHFFFAOYSA-N 676462 US20240166635, Example 142a::US20240166635, Example 142b::US20240166635, Example 143a::US20240166635, Example 143b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090250 500592166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416327 CNS(=O)(=O)c1ccc(Nc2ncc(Br)c(OC3CCCC3O)n2)cc1 InChI=1S/C16H19BrN4O4S/c1-18-26(23,24)11-7-5-10(6-8-11)20-16-19-9-12(17)15(21-16)25-14-4-2-3-13(14)22/h5-9,13-14,18,22H,2-4H2,1H3,(H,19,20,21) NHBKBNJTRGHNMQ-UHFFFAOYSA-N 676462 US20240166635, Example 142a::US20240166635, Example 142b::US20240166635, Example 143a::US20240166635, Example 143b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676462&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090250 500592166 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416330 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(Br)c(OC2CCCCC2O)n1 InChI=1S/C19H27BrN6O4S/c1-25-12-14(10-22-25)31(28,29)26-8-6-13(7-9-26)23-19-21-11-15(20)18(24-19)30-17-5-3-2-4-16(17)27/h10-13,16-17,27H,2-9H2,1H3,(H,21,23,24) VBTFDZNKWVGQPG-UHFFFAOYSA-N 676466 US20240166635, Example 144a::US20240166635, Example 144b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676466&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581960 500592167 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416336 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(Br)c(OC2CCCCC2O)n1 InChI=1S/C19H27BrN6O4S/c1-25-12-14(10-22-25)31(28,29)26-8-6-13(7-9-26)23-19-21-11-15(20)18(24-19)30-17-5-3-2-4-16(17)27/h10-13,16-17,27H,2-9H2,1H3,(H,21,23,24) VBTFDZNKWVGQPG-UHFFFAOYSA-N 676466 US20240166635, Example 144a::US20240166635, Example 144b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676466&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581960 500592167 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416339 CS(=O)(=O)N1CCC(CC1)Nc1ncc(Br)c(OC2CCCCCC2O)n1 InChI=1S/C17H27BrN4O4S/c1-27(24,25)22-9-7-12(8-10-22)20-17-19-11-13(18)16(21-17)26-15-6-4-2-3-5-14(15)23/h11-12,14-15,23H,2-10H2,1H3,(H,19,20,21) KNSBENBIJKAOTM-UHFFFAOYSA-N 676468 US20240166635, Example 145a::US20240166635, Example 145b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676468&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089967 500592168 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416345 CS(=O)(=O)N1CCC(CC1)Nc1ncc(Br)c(OC2CCCCCC2O)n1 InChI=1S/C17H27BrN4O4S/c1-27(24,25)22-9-7-12(8-10-22)20-17-19-11-13(18)16(21-17)26-15-6-4-2-3-5-14(15)23/h11-12,14-15,23H,2-10H2,1H3,(H,19,20,21) KNSBENBIJKAOTM-UHFFFAOYSA-N 676468 US20240166635, Example 145a::US20240166635, Example 145b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676468&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089967 500592168 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416351 Cc1cnc(Nc2ccc(cc2)S(=O)(=O)NC2CC2)nc1OC1CCCC1O InChI=1S/C19H24N4O4S/c1-12-11-20-19(22-18(12)27-17-4-2-3-16(17)24)21-13-7-9-15(10-8-13)28(25,26)23-14-5-6-14/h7-11,14,16-17,23-24H,2-6H2,1H3,(H,20,21,22) RCMDDAKHUFLBAQ-UHFFFAOYSA-N 676470 US20240166635, Example 146a::US20240166635, Example 146b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090088 500592169 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416354 Cc1cnc(Nc2ccc(cc2)S(=O)(=O)NC2CC2)nc1OC1CCCC1O InChI=1S/C19H24N4O4S/c1-12-11-20-19(22-18(12)27-17-4-2-3-16(17)24)21-13-7-9-15(10-8-13)28(25,26)23-14-5-6-14/h7-11,14,16-17,23-24H,2-6H2,1H3,(H,20,21,22) RCMDDAKHUFLBAQ-UHFFFAOYSA-N 676470 US20240166635, Example 146a::US20240166635, Example 146b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676470&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090088 500592169 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416360 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C)c(OC3CCCC3O)n2)cc1 InChI=1S/C19H26N4O4S/c1-12(2)23-28(25,26)15-9-7-14(8-10-15)21-19-20-11-13(3)18(22-19)27-17-6-4-5-16(17)24/h7-12,16-17,23-24H,4-6H2,1-3H3,(H,20,21,22) HOISFQJJCQCQFV-UHFFFAOYSA-N 676472 US20240166635, Example 147a::US20240166635, Example 147b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676472&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990675 500592170 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416363 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(C)c(OC3CCCC3O)n2)cc1 InChI=1S/C19H26N4O4S/c1-12(2)23-28(25,26)15-9-7-14(8-10-15)21-19-20-11-13(3)18(22-19)27-17-6-4-5-16(17)24/h7-12,16-17,23-24H,4-6H2,1-3H3,(H,20,21,22) HOISFQJJCQCQFV-UHFFFAOYSA-N 676472 US20240166635, Example 147a::US20240166635, Example 147b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676472&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990675 500592170 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415676 Cn1cnc(c1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2(C)O)n1 InChI=1S/C20H27N7O4S/c1-20(28)7-3-4-16(20)31-18-14(10-21)11-22-19(25-18)24-15-5-8-27(9-6-15)32(29,30)17-12-26(2)13-23-17/h11-13,15-16,28H,3-9H2,1-2H3,(H,22,24,25) QCBLVLKFDWENOV-UHFFFAOYSA-N 676327 US20240166635, Example 50a::US20240166635, Example 50b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676327&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090094 500592063 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415694 CS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CCCC2)n1 InChI=1S/C16H23N5O3S/c1-25(22,23)21-8-6-13(7-9-21)19-16-18-11-12(10-17)15(20-16)24-14-4-2-3-5-14/h11,13-14H,2-9H2,1H3,(H,18,19,20) NFRIEKMTZDQPPU-UHFFFAOYSA-N 676331 US20240166635, Example 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676331&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164855024 500592065 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415700 CC1(COc2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2C#N)CCC1 InChI=1S/C17H25N5O3S/c1-17(6-3-7-17)12-25-15-13(10-18)11-19-16(21-15)20-14-4-8-22(9-5-14)26(2,23)24/h11,14H,3-9,12H2,1-2H3,(H,19,20,21) IUGKQCKADAUULW-UHFFFAOYSA-N 676332 US20240166635, Example 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676332&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090308 500592066 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415706 CC1(COc2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2C#N)CCCC1 InChI=1S/C18H27N5O3S/c1-18(7-3-4-8-18)13-26-16-14(11-19)12-20-17(22-16)21-15-5-9-23(10-6-15)27(2,24)25/h12,15H,3-10,13H2,1-2H3,(H,20,21,22) JVBPIKUNIDNBCH-UHFFFAOYSA-N 676333 US20240166635, Example 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676333&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090305 500592067 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415853 CC1(C)CCCN(C1)c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C18H22N6O2S/c1-18(2)8-3-9-24(12-18)16-13(10-19)11-21-17(23-16)22-14-4-6-15(7-5-14)27(20,25)26/h4-7,11H,3,8-9,12H2,1-2H3,(H2,20,25,26)(H,21,22,23) QBZZEVQQFQCIRK-UHFFFAOYSA-N 676363 US20240166635, Example 83 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676363&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090013 500592097 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416369 CNS(=O)(=O)c1ccc(Nc2ncc(C)c(OC3CCCC3O)n2)cc1 InChI=1S/C17H22N4O4S/c1-11-10-19-17(21-16(11)25-15-5-3-4-14(15)22)20-12-6-8-13(9-7-12)26(23,24)18-2/h6-10,14-15,18,22H,3-5H2,1-2H3,(H,19,20,21) OELWRYRKFMYGJW-UHFFFAOYSA-N 676474 US20240166635, Example 148a::US20240166635, Example 148b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676474&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990676 500592171 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416372 CNS(=O)(=O)c1ccc(Nc2ncc(C)c(OC3CCCC3O)n2)cc1 InChI=1S/C17H22N4O4S/c1-11-10-19-17(21-16(11)25-15-5-3-4-14(15)22)20-12-6-8-13(9-7-12)26(23,24)18-2/h6-10,14-15,18,22H,3-5H2,1-2H3,(H,19,20,21) OELWRYRKFMYGJW-UHFFFAOYSA-N 676474 US20240166635, Example 148a::US20240166635, Example 148b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676474&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990676 500592171 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416378 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1CCCC1O InChI=1S/C18H24N4O4S/c1-3-12-11-20-18(22-17(12)26-16-6-4-5-15(16)23)21-13-7-9-14(10-8-13)27(24,25)19-2/h7-11,15-16,19,23H,3-6H2,1-2H3,(H,20,21,22) SKHNNUOJRNSIFG-UHFFFAOYSA-N 676476 US20240166635, Example 149a::US20240166635, Example 149b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676476&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990677 500592172 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416381 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1CCCC1O InChI=1S/C18H24N4O4S/c1-3-12-11-20-18(22-17(12)26-16-6-4-5-15(16)23)21-13-7-9-14(10-8-13)27(24,25)19-2/h7-11,15-16,19,23H,3-6H2,1-2H3,(H,20,21,22) SKHNNUOJRNSIFG-UHFFFAOYSA-N 676476 US20240166635, Example 149a::US20240166635, Example 149b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676476&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990677 500592172 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416387 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1COCC1(C)O InChI=1S/C18H24N4O5S/c1-4-12-9-20-17(22-16(12)27-15-10-26-11-18(15,2)23)21-13-5-7-14(8-6-13)28(24,25)19-3/h5-9,15,19,23H,4,10-11H2,1-3H3,(H,20,21,22) ZYIUATVXCNVESH-UHFFFAOYSA-N 676478 US20240166635, Example 150a::US20240166635, Example 150b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676478&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990678 500592173 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416395 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1CCOCC1O InChI=1S/C18H24N4O5S/c1-3-12-10-20-18(22-17(12)27-16-8-9-26-11-15(16)23)21-13-4-6-14(7-5-13)28(24,25)19-2/h4-7,10,15-16,19,23H,3,8-9,11H2,1-2H3,(H,20,21,22) WEPISGPURNHABS-UHFFFAOYSA-N 676480 US20240166635, Example 151a::US20240166635, Example 151b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990679 500592174 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416398 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1CCOCC1O InChI=1S/C18H24N4O5S/c1-3-12-10-20-18(22-17(12)27-16-8-9-26-11-15(16)23)21-13-4-6-14(7-5-13)28(24,25)19-2/h4-7,10,15-16,19,23H,3,8-9,11H2,1-2H3,(H,20,21,22) WEPISGPURNHABS-UHFFFAOYSA-N 676480 US20240166635, Example 151a::US20240166635, Example 151b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676480&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990679 500592174 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416401 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1CCOCC1(C)O InChI=1S/C19H26N4O5S/c1-4-13-11-21-18(22-14-5-7-15(8-6-14)29(25,26)20-3)23-17(13)28-16-9-10-27-12-19(16,2)24/h5-8,11,16,20,24H,4,9-10,12H2,1-3H3,(H,21,22,23) WFDAMUXNSQYUMN-UHFFFAOYSA-N 676482 US20240166635, Example 152a::US20240166635, Example 152b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676482&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990680 500592175 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416404 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1CCOCC1(C)O InChI=1S/C19H26N4O5S/c1-4-13-11-21-18(22-14-5-7-15(8-6-14)29(25,26)20-3)23-17(13)28-16-9-10-27-12-19(16,2)24/h5-8,11,16,20,24H,4,9-10,12H2,1-3H3,(H,21,22,23) WFDAMUXNSQYUMN-UHFFFAOYSA-N 676482 US20240166635, Example 152a::US20240166635, Example 152b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676482&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990680 500592175 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415712 CNS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CCCC2)n1 InChI=1S/C18H28N6O3S/c1-18(7-3-4-8-18)13-27-16-14(11-19)12-21-17(23-16)22-15-5-9-24(10-6-15)28(25,26)20-2/h12,15,20H,3-10,13H2,1-2H3,(H,21,22,23) RTOZTQPNHKYMFF-UHFFFAOYSA-N 676334 US20240166635, Example 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676334&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089916 500592068 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415718 CC1(COc2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2C#N)CCCC1 InChI=1S/C17H26N6O3S/c1-17(6-2-3-7-17)12-26-15-13(10-18)11-20-16(22-15)21-14-4-8-23(9-5-14)27(19,24)25/h11,14H,2-9,12H2,1H3,(H2,19,24,25)(H,20,21,22) WGPONUKJUHDRKT-UHFFFAOYSA-N 676335 US20240166635, Example 56 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676335&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089921 500592069 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415724 CC1(COc2nc(NC3CCN(CC3)S(=O)(=O)CCO)ncc2C#N)CCCC1 InChI=1S/C19H29N5O4S/c1-19(6-2-3-7-19)14-28-17-15(12-20)13-21-18(23-17)22-16-4-8-24(9-5-16)29(26,27)11-10-25/h13,16,25H,2-11,14H2,1H3,(H,21,22,23) TUWIDIPOQFITJN-UHFFFAOYSA-N 676336 US20240166635, Example 57 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676336&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089917 500592070 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415730 COCCS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CCCC2)n1 InChI=1S/C20H31N5O4S/c1-20(7-3-4-8-20)15-29-18-16(13-21)14-22-19(24-18)23-17-5-9-25(10-6-17)30(26,27)12-11-28-2/h14,17H,3-12,15H2,1-2H3,(H,22,23,24) JZYAYXLXBYQUJR-UHFFFAOYSA-N 676337 US20240166635, Example 58 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676337&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089924 500592071 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415736 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OC2CC3(CCC3)C2)n1 InChI=1S/C21H27N7O3S/c1-27-14-18(13-24-27)32(29,30)28-7-3-16(4-8-28)25-20-23-12-15(11-22)19(26-20)31-17-9-21(10-17)5-2-6-21/h12-14,16-17H,2-10H2,1H3,(H,23,25,26) JJTOOCRKQWDIDD-UHFFFAOYSA-N 676338 US20240166635, Example 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676338&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581906 500592072 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415742 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CCC2)n1 InChI=1S/C20H27N7O3S/c1-20(6-3-7-20)14-30-18-15(10-21)11-22-19(25-18)24-16-4-8-27(9-5-16)31(28,29)17-12-23-26(2)13-17/h11-13,16H,3-9,14H2,1-2H3,(H,22,24,25) ONSDZEZFRFUDNV-UHFFFAOYSA-N 676339 US20240166635, Example 60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676339&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089923 500592073 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415748 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CC(F)(F)C2)n1 InChI=1S/C20H25F2N7O3S/c1-19(11-20(21,22)12-19)13-32-17-14(7-23)8-24-18(27-17)26-15-3-5-29(6-4-15)33(30,31)16-9-25-28(2)10-16/h8-10,15H,3-6,11-13H2,1-2H3,(H,24,26,27) QUWHYVIAUBWWFO-UHFFFAOYSA-N 676340 US20240166635, Example 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676340&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171582026 500592074 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415754 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CCCC2)n1 InChI=1S/C21H29N7O3S/c1-21(7-3-4-8-21)15-31-19-16(11-22)12-23-20(26-19)25-17-5-9-28(10-6-17)32(29,30)18-13-24-27(2)14-18/h12-14,17H,3-10,15H2,1-2H3,(H,23,25,26) MXLQXNPUTMMXQE-UHFFFAOYSA-N 676341 US20240166635, Example 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676341&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089922 500592075 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415860 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCCC(C2)c2ccccc2)cc1 InChI=1S/C22H22N6O2S/c23-13-18-14-25-22(26-19-8-10-20(11-9-19)31(24,29)30)27-21(18)28-12-4-7-17(15-28)16-5-2-1-3-6-16/h1-3,5-6,8-11,14,17H,4,7,12,15H2,(H2,24,29,30)(H,25,26,27) DUAHUWZSSCBNCQ-UHFFFAOYSA-N 676364 US20240166635, Example 84::US20240166635, Example 85 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676364&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090154 500592098 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415865 NS(=O)(=O)c1ccc(Nc2ncc(F)c(n2)N2CCCCC2)cc1 InChI=1S/C15H18FN5O2S/c16-13-10-18-15(20-14(13)21-8-2-1-3-9-21)19-11-4-6-12(7-5-11)24(17,22)23/h4-7,10H,1-3,8-9H2,(H2,17,22,23)(H,18,19,20) FTJDGUPVEVBZFA-UHFFFAOYSA-N 676366 US20240166635, Example 86 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676366&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090155 500592099 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415873 CS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)N1CCCCC1 InChI=1S/C16H24N6O2S/c1-25(23,24)22-9-5-14(6-10-22)19-16-18-12-13(11-17)15(20-16)21-7-3-2-4-8-21/h12,14H,2-10H2,1H3,(H,18,19,20) OCARTNNFCDDTMN-UHFFFAOYSA-N 676369 US20240166635, Example 89 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676369&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090298 500592102 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415881 CNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCCCC2)cc1 InChI=1S/C17H20N6O2S/c1-19-26(24,25)15-7-5-14(6-8-15)21-17-20-12-13(11-18)16(22-17)23-9-3-2-4-10-23/h5-8,12,19H,2-4,9-10H2,1H3,(H,20,21,22) YUOHLMLGTIBJMB-UHFFFAOYSA-N 676371 US20240166635, Example 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676371&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090289 500592104 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415886 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)-c2ccc(O)cc2)cc1 InChI=1S/C17H13N5O3S/c18-9-12-10-20-17(22-16(12)11-1-5-14(23)6-2-11)21-13-3-7-15(8-4-13)26(19,24)25/h1-8,10,23H,(H2,19,24,25)(H,20,21,22) YQVYMELPOPTNDV-UHFFFAOYSA-N 676372 US20240166635, Example 92 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676372&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090135 500592105 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415891 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)-c2ccccc2)cc1 InChI=1S/C17H13N5O2S/c18-10-13-11-20-17(22-16(13)12-4-2-1-3-5-12)21-14-6-8-15(9-7-14)25(19,23)24/h1-9,11H,(H2,19,23,24)(H,20,21,22) IGOROQLHPXKXMH-UHFFFAOYSA-N 676373 US20240166635, Example 93 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676373&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090295 500592106 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415897 Cc1cccc(c1)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C18H15N5O2S/c1-12-3-2-4-13(9-12)17-14(10-19)11-21-18(23-17)22-15-5-7-16(8-6-15)26(20,24)25/h2-9,11H,1H3,(H2,20,24,25)(H,21,22,23) WWUCODWMCLZRMM-UHFFFAOYSA-N 676374 US20240166635, Example 94 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676374&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090290 500592107 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416410 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1COCCC1(C)O InChI=1S/C19H26N4O5S/c1-4-13-11-21-18(22-14-5-7-15(8-6-14)29(25,26)20-3)23-17(13)28-16-12-27-10-9-19(16,2)24/h5-8,11,16,20,24H,4,9-10,12H2,1-3H3,(H,21,22,23) KQLNBJJXDOONCE-UHFFFAOYSA-N 676484 US20240166635, Example 153a::US20240166635, Example 153b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676484&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990681 500592176 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416413 CCc1cnc(Nc2ccc(cc2)S(=O)(=O)NC)nc1OC1COCCC1(C)O InChI=1S/C19H26N4O5S/c1-4-13-11-21-18(22-14-5-7-15(8-6-14)29(25,26)20-3)23-17(13)28-16-12-27-10-9-19(16,2)24/h5-8,11,16,20,24H,4,9-10,12H2,1-3H3,(H,21,22,23) KQLNBJJXDOONCE-UHFFFAOYSA-N 676484 US20240166635, Example 153a::US20240166635, Example 153b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676484&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990681 500592176 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416419 CC1(O)CCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C1CC1 InChI=1S/C19H24N4O4S/c1-19(24)10-2-3-16(19)27-17-15(12-4-5-12)11-21-18(23-17)22-13-6-8-14(9-7-13)28(20,25)26/h6-9,11-12,16,24H,2-5,10H2,1H3,(H2,20,25,26)(H,21,22,23) BYZQLJVRMDAADW-UHFFFAOYSA-N 676486 US20240166635, Example 154a::US20240166635, Example 154b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676486&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581979 500592177 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416422 CC1(O)CCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C1CC1 InChI=1S/C19H24N4O4S/c1-19(24)10-2-3-16(19)27-17-15(12-4-5-12)11-21-18(23-17)22-13-6-8-14(9-7-13)28(20,25)26/h6-9,11-12,16,24H,2-5,10H2,1H3,(H2,20,25,26)(H,21,22,23) BYZQLJVRMDAADW-UHFFFAOYSA-N 676486 US20240166635, Example 154a::US20240166635, Example 154b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676486&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581979 500592177 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416428 NS(=O)(=O)c1ccc(Nc2ncc(C=C)c(OC3CCCC3O)n2)cc1 InChI=1S/C17H20N4O4S/c1-2-11-10-19-17(21-16(11)25-15-5-3-4-14(15)22)20-12-6-8-13(9-7-12)26(18,23)24/h2,6-10,14-15,22H,1,3-5H2,(H2,18,23,24)(H,19,20,21) BNFADTVYPPIEFB-UHFFFAOYSA-N 676488 US20240166635, Example 155a::US20240166635, Example 155b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676488&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090009 500592178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416431 NS(=O)(=O)c1ccc(Nc2ncc(C=C)c(OC3CCCC3O)n2)cc1 InChI=1S/C17H20N4O4S/c1-2-11-10-19-17(21-16(11)25-15-5-3-4-14(15)22)20-12-6-8-13(9-7-12)26(18,23)24/h2,6-10,14-15,22H,1,3-5H2,(H2,18,23,24)(H,19,20,21) BNFADTVYPPIEFB-UHFFFAOYSA-N 676488 US20240166635, Example 155a::US20240166635, Example 155b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676488&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090009 500592178 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415760 Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CCCC2)n1 InChI=1S/C21H29N7O3S/c1-21(8-3-4-9-21)15-31-19-16(13-22)14-23-20(25-19)24-17-5-11-28(12-6-17)32(29,30)18-7-10-27(2)26-18/h7,10,14,17H,3-6,8-9,11-12,15H2,1-2H3,(H,23,24,25) MVTRGLCCCNTBRI-UHFFFAOYSA-N 676342 US20240166635, Example 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676342&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089920 500592076 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415770 CO[C@H]1CC(C)(COc2nc(NC3CCN(CC3)S(=O)(=O)c3cnn(C)c3)ncc2C#N)C1 InChI=1S/C21H29N7O4S/c1-21(8-17(9-21)31-3)14-32-19-15(10-22)11-23-20(26-19)25-16-4-6-28(7-5-16)33(29,30)18-12-24-27(2)13-18/h11-13,16-17H,4-9,14H2,1-3H3,(H,23,25,26)/t17-,21? PRSYHOVETSXLAW-KJPGQXGLSA-N 676344 US20240166635, Example 64b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676344&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089918 500592078 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415776 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCCCC2)cc1 InChI=1S/C16H18N6O2S/c17-10-12-11-19-16(21-15(12)22-8-2-1-3-9-22)20-13-4-6-14(7-5-13)25(18,23)24/h4-7,11H,1-3,8-9H2,(H2,18,23,24)(H,19,20,21) NBOMRDUNYYSFKM-UHFFFAOYSA-N 676345 US20240166635, Example 65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676345&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090089 500592079 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415781 O=S(=O)(NC1COC1)c1ccc(Nc2ncc(C#N)c(n2)N2CCCCC2)cc1 InChI=1S/C19H22N6O3S/c20-10-14-11-21-19(23-18(14)25-8-2-1-3-9-25)22-15-4-6-17(7-5-15)29(26,27)24-16-12-28-13-16/h4-7,11,16,24H,1-3,8-9,12-13H2,(H,21,22,23) QNPDOIYFTPKZBE-UHFFFAOYSA-N 676346 US20240166635, Example 66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676346&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090093 500592080 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415785 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCCC2)cc1 InChI=1S/C15H16N6O2S/c16-9-11-10-18-15(20-14(11)21-7-1-2-8-21)19-12-3-5-13(6-4-12)24(17,22)23/h3-6,10H,1-2,7-8H2,(H2,17,22,23)(H,18,19,20) YKFDYHJLVVHLTA-UHFFFAOYSA-N 676347 US20240166635, Example 67 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676347&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090215 500592081 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415791 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCCCCC2)cc1 InChI=1S/C17H20N6O2S/c18-11-13-12-20-17(22-16(13)23-9-3-1-2-4-10-23)21-14-5-7-15(8-6-14)26(19,24)25/h5-8,12H,1-4,9-10H2,(H2,19,24,25)(H,20,21,22) MUUHVLDSAITAAO-UHFFFAOYSA-N 676348 US20240166635, Example 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676348&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171581863 500592082 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415908 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)-c2cccc(c2)C2CC2)cc1 InChI=1S/C20H17N5O2S/c21-11-16-12-23-20(24-17-6-8-18(9-7-17)28(22,26)27)25-19(16)15-3-1-2-14(10-15)13-4-5-13/h1-3,6-10,12-13H,4-5H2,(H2,22,26,27)(H,23,24,25) CYCJLUNVGZAGRO-UHFFFAOYSA-N 676376 US20240166635, Example 96 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676376&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090293 500592109 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415919 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)-c2cccc(O)c2)cc1 InChI=1S/C17H13N5O3S/c18-9-12-10-20-17(22-16(12)11-2-1-3-14(23)8-11)21-13-4-6-15(7-5-13)26(19,24)25/h1-8,10,23H,(H2,19,24,25)(H,20,21,22) LRALYODTTDLYCD-UHFFFAOYSA-N 676378 US20240166635, Example 98 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676378&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090288 500592111 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415925 NS(=O)(=O)c1ccc(Nc2ncc(c(O[C@H]3CCC[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O4S/c17-16(18,19)11-8-21-15(23-14(11)27-13-3-1-2-12(13)24)22-9-4-6-10(7-5-9)28(20,25)26/h4-8,12-13,24H,1-3H2,(H2,20,25,26)(H,21,22,23)/t12-,13+/m1/s1 ALDIKYMFXCVIAW-OLZOCXBDSA-N 676379 US20240166635, Example 99a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676379&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090063 500592112 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415928 NS(=O)(=O)c1ccc(Nc2ncc(c(O[C@@H]3CCC[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O4S/c17-16(18,19)11-8-21-15(23-14(11)27-13-3-1-2-12(13)24)22-9-4-6-10(7-5-9)28(20,25)26/h4-8,12-13,24H,1-3H2,(H2,20,25,26)(H,21,22,23)/t12-,13-/m1/s1 ALDIKYMFXCVIAW-CHWSQXEVSA-N 676380 US20240166635, Example 99b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676380&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990656 500592113 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415934 CNS(=O)(=O)c1ccc(Nc2ncc(c(O[C@H]3CCOC[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O5S/c1-21-30(26,27)11-4-2-10(3-5-11)23-16-22-8-12(17(18,19)20)15(24-16)29-14-6-7-28-9-13(14)25/h2-5,8,13-14,21,25H,6-7,9H2,1H3,(H,22,23,24)/t13-,14+/m1/s1 PCCSUZXFRYBZTH-KGLIPLIRSA-N 676381 US20240166635, Example 100a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676381&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090320 500592114 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415937 CNS(=O)(=O)c1ccc(Nc2ncc(c(O[C@@H]3CCOC[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O5S/c1-21-30(26,27)11-4-2-10(3-5-11)23-16-22-8-12(17(18,19)20)15(24-16)29-14-6-7-28-9-13(14)25/h2-5,8,13-14,21,25H,6-7,9H2,1H3,(H,22,23,24)/t13-,14-/m1/s1 PCCSUZXFRYBZTH-ZIAGYGMSSA-N 676382 US20240166635, Example 100b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676382&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990657 500592115 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415795 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCC[C@H](O)C2)cc1 InChI=1S/C16H18N6O3S/c17-8-11-9-19-16(21-15(11)22-7-1-2-13(23)10-22)20-12-3-5-14(6-4-12)26(18,24)25/h3-6,9,13,23H,1-2,7,10H2,(H2,18,24,25)(H,19,20,21)/t13-/m0/s1 DFJLEZDVQRKMPU-ZDUSSCGKSA-N 676349 US20240166635, Example 69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676349&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090204 500592083 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415799 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCC[C@@H](O)C2)cc1 InChI=1S/C16H18N6O3S/c17-8-11-9-19-16(21-15(11)22-7-1-2-13(23)10-22)20-12-3-5-14(6-4-12)26(18,24)25/h3-6,9,13,23H,1-2,7,10H2,(H2,18,24,25)(H,19,20,21)/t13-/m1/s1 DFJLEZDVQRKMPU-CYBMUJFWSA-N 676350 US20240166635, Example 70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676350&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090207 500592084 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415804 C[C@H]1CCCN(C1)c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O2S/c1-12-3-2-8-23(11-12)16-13(9-18)10-20-17(22-16)21-14-4-6-15(7-5-14)26(19,24)25/h4-7,10,12H,2-3,8,11H2,1H3,(H2,19,24,25)(H,20,21,22)/t12-/m0/s1 IGLHISZMQZPVOP-LBPRGKRZSA-N 676351 US20240166635, Example 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676351&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090198 500592085 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415809 C[C@@H]1CCCN(C1)c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O2S/c1-12-3-2-8-23(11-12)16-13(9-18)10-20-17(22-16)21-14-4-6-15(7-5-14)26(19,24)25/h4-7,10,12H,2-3,8,11H2,1H3,(H2,19,24,25)(H,20,21,22)/t12-/m1/s1 IGLHISZMQZPVOP-GFCCVEGCSA-N 676352 US20240166635, Example 72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676352&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090199 500592086 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415814 C[C@@H]1CCCCN1c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O2S/c1-12-4-2-3-9-23(12)16-13(10-18)11-20-17(22-16)21-14-5-7-15(8-6-14)26(19,24)25/h5-8,11-12H,2-4,9H2,1H3,(H2,19,24,25)(H,20,21,22)/t12-/m1/s1 CPPKSKHDVMJSGS-GFCCVEGCSA-N 676353 US20240166635, Example 73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676353&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090197 500592087 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415819 C[C@H]1CCCCN1c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O2S/c1-12-4-2-3-9-23(12)16-13(10-18)11-20-17(22-16)21-14-5-7-15(8-6-14)26(19,24)25/h5-8,11-12H,2-4,9H2,1H3,(H2,19,24,25)(H,20,21,22)/t12-/m0/s1 CPPKSKHDVMJSGS-LBPRGKRZSA-N 676354 US20240166635, Example 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676354&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090106 500592088 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415822 C[C@@H]1C[C@H](O)CCN1c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O3S/c1-11-8-14(24)6-7-23(11)16-12(9-18)10-20-17(22-16)21-13-2-4-15(5-3-13)27(19,25)26/h2-5,10-11,14,24H,6-8H2,1H3,(H2,19,25,26)(H,20,21,22)/t11-,14-/m1/s1 FKGVEVODLHDCHI-BXUZGUMPSA-N 676355 US20240166635, Example 75 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676355&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090104 500592089 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415825 C[C@@H]1C[C@@H](O)CCN1c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O3S/c1-11-8-14(24)6-7-23(11)16-12(9-18)10-20-17(22-16)21-13-2-4-15(5-3-13)27(19,25)26/h2-5,10-11,14,24H,6-8H2,1H3,(H2,19,25,26)(H,20,21,22)/t11-,14+/m1/s1 FKGVEVODLHDCHI-RISCZKNCSA-N 676356 US20240166635, Example 76 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676356&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090105 500592090 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415828 C[C@@H]1CC[C@H](O)CN1c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H20N6O3S/c1-11-2-5-14(24)10-23(11)16-12(8-18)9-20-17(22-16)21-13-3-6-15(7-4-13)27(19,25)26/h3-4,6-7,9,11,14,24H,2,5,10H2,1H3,(H2,19,25,26)(H,20,21,22)/t11-,14+/m1/s1 BIAJLXSVBJCKIY-RISCZKNCSA-N 676357 US20240166635, Example 77 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676357&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090205 500592091 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415831 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCC[C@H](CO)C2)cc1 InChI=1S/C17H20N6O3S/c18-8-13-9-20-17(21-14-3-5-15(6-4-14)27(19,25)26)22-16(13)23-7-1-2-12(10-23)11-24/h3-6,9,12,24H,1-2,7,10-11H2,(H2,19,25,26)(H,20,21,22)/t12-/m0/s1 IYAKNQMMYNUAIY-LBPRGKRZSA-N 676358 US20240166635, Example 78 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676358&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090248 500592092 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415834 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCC[C@@H](CO)C2)cc1 InChI=1S/C17H20N6O3S/c18-8-13-9-20-17(21-14-3-5-15(6-4-14)27(19,25)26)22-16(13)23-7-1-2-12(10-23)11-24/h3-6,9,12,24H,1-2,7,10-11H2,(H2,19,25,26)(H,20,21,22)/t12-/m1/s1 IYAKNQMMYNUAIY-GFCCVEGCSA-N 676359 US20240166635, Example 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676359&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090247 500592093 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415943 CNS(=O)(=O)c1ccc(Nc2ncc(c(O[C@H]3CCOC[C@H]3O)n2)C(F)(F)F)c(F)c1 InChI=1S/C17H18F4N4O5S/c1-22-31(27,28)9-2-3-12(11(18)6-9)24-16-23-7-10(17(19,20)21)15(25-16)30-14-4-5-29-8-13(14)26/h2-3,6-7,13-14,22,26H,4-5,8H2,1H3,(H,23,24,25)/t13-,14+/m1/s1 PNHFLLNBUUXGEW-KGLIPLIRSA-N 676383 US20240166635, Example 101a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676383&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990658 500592116 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415972 CNS(=O)(=O)c1ccc(Nc2ncc(c(O[C@H]3CCCOC[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C18H21F3N4O5S/c1-22-31(27,28)12-6-4-11(5-7-12)24-17-23-9-13(18(19,20)21)16(25-17)30-15-3-2-8-29-10-14(15)26/h4-7,9,14-15,22,26H,2-3,8,10H2,1H3,(H,23,24,25)/t14-,15+/m1/s1 SVFDHGCURGAGIM-CABCVRRESA-N 676385 US20240166635, Example 102a::US20240166635, Example 103a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676385&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990660 500592118 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415983 C[C@@]1(O)COC[C@@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C(F)(F)F InChI=1S/C16H23F3N4O5S/c1-15(24)9-27-8-12(15)28-13-11(16(17,18)19)7-20-14(22-13)21-10-3-5-23(6-4-10)29(2,25)26/h7,10,12,24H,3-6,8-9H2,1-2H3,(H,20,21,22)/t12-,15+/m0/s1 MWILTCFDLRXJDY-SWLSCSKDSA-N 676391 US20240166635, Example 104a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676391&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090148 500592122 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415277 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OCC3CCCC3)n2)cc1 InChI=1S/C17H19N5O3S/c18-9-13-10-20-17(22-16(13)25-11-12-3-1-2-4-12)21-14-5-7-15(8-6-14)26(19,23)24/h5-8,10,12H,1-4,11H2,(H2,19,23,24)(H,20,21,22) KDYMFYUQBRLCPF-UHFFFAOYSA-N 676208 US20240166635, Example 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676208&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090124 500591978 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415283 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(O[C@H]3CCCC[C@H]3O)n2)cc1 InChI=1S/C17H19N5O4S/c18-9-11-10-20-17(21-12-5-7-13(8-6-12)27(19,24)25)22-16(11)26-15-4-2-1-3-14(15)23/h5-8,10,14-15,23H,1-4H2,(H2,19,24,25)(H,20,21,22)/t14-,15+/m1/s1 FMDFEAPBRWULAI-CABCVRRESA-N 676209 US20240166635, Example 2a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676209&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090065 500591979 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415286 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(O[C@H]3CCCC[C@@H]3O)n2)cc1 InChI=1S/C17H19N5O4S/c18-9-11-10-20-17(21-12-5-7-13(8-6-12)27(19,24)25)22-16(11)26-15-4-2-1-3-14(15)23/h5-8,10,14-15,23H,1-4H2,(H2,19,24,25)(H,20,21,22)/t14-,15-/m0/s1 FMDFEAPBRWULAI-GJZGRUSLSA-N 676210 US20240166635, Example 2b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676210&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990625 500591980 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415289 C[C@@]1(O)CCC[C@@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H25N5O4S/c1-17(23)7-3-4-14(17)26-15-12(10-18)11-19-16(21-15)20-13-5-8-22(9-6-13)27(2,24)25/h11,13-14,23H,3-9H2,1-2H3,(H,19,20,21)/t14-,17+/m0/s1 IETNNOKBNYLBJP-WMLDXEAASA-N 676211 US20240166635, Example 3a::US20240166635, Example 5a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676211&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089932 500591981 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415295 C[C@@]1(O)CCC[C@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H25N5O4S/c1-17(23)7-3-4-14(17)26-15-12(10-18)11-19-16(21-15)20-13-5-8-22(9-6-13)27(2,24)25/h11,13-14,23H,3-9H2,1-2H3,(H,19,20,21)/t14-,17-/m1/s1 IETNNOKBNYLBJP-RHSMWYFYSA-N 676212 US20240166635, Example 3b::US20240166635, Example 5b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990626 500591982 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415301 C[C@@]1(O)CC(F)(F)C[C@@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H23F2N5O4S/c1-16(25)10-17(18,19)7-13(16)28-14-11(8-20)9-21-15(23-14)22-12-3-5-24(6-4-12)29(2,26)27/h9,12-13,25H,3-7,10H2,1-2H3,(H,21,22,23)/t13-,16+/m0/s1 OUOWWDXNOOHBGP-XJKSGUPXSA-N 676213 US20240166635, Example 4a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676213&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090147 500591983 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415988 C[C@@]1(O)COC[C@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C(F)(F)F InChI=1S/C16H23F3N4O5S/c1-15(24)9-27-8-12(15)28-13-11(16(17,18)19)7-20-14(22-13)21-10-3-5-23(6-4-10)29(2,25)26/h7,10,12,24H,3-6,8-9H2,1-2H3,(H,20,21,22)/t12-,15-/m1/s1 MWILTCFDLRXJDY-IUODEOHRSA-N 676392 US20240166635, Example 104b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676392&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990664 500592123 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415994 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c1-21-29(26,27)11-7-5-10(6-8-11)23-16-22-9-12(17(18,19)20)15(24-16)28-14-4-2-3-13(14)25/h5-9,13-14,21,25H,2-4H2,1H3,(H,22,23,24) ARZCNFVGTWMROY-UHFFFAOYSA-N 676393 US20240166635, Example 105a::US20240166635, Example 105b::US20240166635, Example 109a::US20240166635, Example 109b::US20240166635, Example 110a::US20240166635, Example 110b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090112 500592124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415997 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c1-21-29(26,27)11-7-5-10(6-8-11)23-16-22-9-12(17(18,19)20)15(24-16)28-14-4-2-3-13(14)25/h5-9,13-14,21,25H,2-4H2,1H3,(H,22,23,24) ARZCNFVGTWMROY-UHFFFAOYSA-N 676393 US20240166635, Example 105a::US20240166635, Example 105b::US20240166635, Example 109a::US20240166635, Example 109b::US20240166635, Example 110a::US20240166635, Example 110b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090112 500592124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416003 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C19H23F3N4O4S/c1-11(2)26-31(28,29)13-8-6-12(7-9-13)24-18-23-10-14(19(20,21)22)17(25-18)30-16-5-3-4-15(16)27/h6-11,15-16,26-27H,3-5H2,1-2H3,(H,23,24,25) YTRZTOPIENEURB-UHFFFAOYSA-N 676395 US20240166635, Example 106a::US20240166635, Example 106b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676395&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090110 500592125 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416006 CC(C)NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C19H23F3N4O4S/c1-11(2)26-31(28,29)13-8-6-12(7-9-13)24-18-23-10-14(19(20,21)22)17(25-18)30-16-5-3-4-15(16)27/h6-11,15-16,26-27H,3-5H2,1-2H3,(H,23,24,25) YTRZTOPIENEURB-UHFFFAOYSA-N 676395 US20240166635, Example 106a::US20240166635, Example 106b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676395&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090110 500592125 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415306 C[C@@]1(O)CC(F)(F)C[C@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H23F2N5O4S/c1-16(25)10-17(18,19)7-13(16)28-14-11(8-20)9-21-15(23-14)22-12-3-5-24(6-4-12)29(2,26)27/h9,12-13,25H,3-7,10H2,1-2H3,(H,21,22,23)/t13-,16-/m1/s1 OUOWWDXNOOHBGP-CZUORRHYSA-N 676214 US20240166635, Example 4b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676214&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990627 500591984 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415311 C[C@@]1(O)CCC[C@@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H25N5O4S/c1-17(23)7-3-4-14(17)26-15-12(10-18)11-19-16(21-15)20-13-5-8-22(9-6-13)27(2,24)25/h11,13-14,23H,3-9H2,1-2H3,(H,19,20,21)/t14-,17+/m0/s1 IETNNOKBNYLBJP-WMLDXEAASA-N 676211 US20240166635, Example 3a::US20240166635, Example 5a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676211&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089932 500591981 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415316 C[C@@]1(O)CCC[C@H]1Oc1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H25N5O4S/c1-17(23)7-3-4-14(17)26-15-12(10-18)11-19-16(21-15)20-13-5-8-22(9-6-13)27(2,24)25/h11,13-14,23H,3-9H2,1-2H3,(H,19,20,21)/t14-,17-/m1/s1 IETNNOKBNYLBJP-RHSMWYFYSA-N 676212 US20240166635, Example 3b::US20240166635, Example 5b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676212&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990626 500591982 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415322 C[C@@]1(O)CCC[C@@H]1Oc1nc(N[C@@H]2CCN(C[C@@H]2F)S(C)(=O)=O)ncc1C#N InChI=1S/C17H24FN5O4S/c1-17(24)6-3-4-14(17)27-15-11(8-19)9-20-16(22-15)21-13-5-7-23(10-12(13)18)28(2,25)26/h9,12-14,24H,3-7,10H2,1-2H3,(H,20,21,22)/t12-,13+,14-,17+/m0/s1 XNTXGZBBRXIZGX-QDEZUTFSSA-N 676217 US20240166635, Example 6a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676217&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090128 500591985 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415325 C[C@@]1(O)CCC[C@@H]1Oc1nc(N[C@@H]2CCN(C[C@H]2F)S(C)(=O)=O)ncc1C#N InChI=1S/C17H24FN5O4S/c1-17(24)6-3-4-14(17)27-15-11(8-19)9-20-16(22-15)21-13-5-7-23(10-12(13)18)28(2,25)26/h9,12-14,24H,3-7,10H2,1-2H3,(H,20,21,22)/t12-,13-,14+,17-/m1/s1 XNTXGZBBRXIZGX-VWPFQQQWSA-N 676224 US20240166635, Example 6b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676224&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990633 500591992 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415328 C[C@@]1(O)CCC[C@H]1Oc1nc(N[C@@H]2CCN(C[C@@H]2F)S(C)(=O)=O)ncc1C#N InChI=1S/C17H24FN5O4S/c1-17(24)6-3-4-14(17)27-15-11(8-19)9-20-16(22-15)21-13-5-7-23(10-12(13)18)28(2,25)26/h9,12-14,24H,3-7,10H2,1-2H3,(H,20,21,22)/t12-,13+,14+,17+/m0/s1 XNTXGZBBRXIZGX-ZOMKSWQUSA-N 676230 US20240166635, Example 6c Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676230&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990638 500591998 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415331 C[C@@]1(O)CCC[C@H]1Oc1nc(N[C@@H]2CCN(C[C@H]2F)S(C)(=O)=O)ncc1C#N InChI=1S/C17H24FN5O4S/c1-17(24)6-3-4-14(17)27-15-11(8-19)9-20-16(22-15)21-13-5-7-23(10-12(13)18)28(2,25)26/h9,12-14,24H,3-7,10H2,1-2H3,(H,20,21,22)/t12-,13-,14-,17-/m1/s1 XNTXGZBBRXIZGX-VMUDFCTBSA-N 676231 US20240166635, Example 6d Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676231&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990639 500591999 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415337 Cn1cc(cn1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(O[C@H]2CCC(F)(F)C[C@@]2(C)O)n1 InChI=1S/C21H27F2N7O4S/c1-20(31)13-21(22,23)6-3-17(20)34-18-14(9-24)10-25-19(28-18)27-15-4-7-30(8-5-15)35(32,33)16-11-26-29(2)12-16/h10-12,15,17,31H,3-8,13H2,1-2H3,(H,25,27,28)/t17-,20+/m0/s1 AXRXMZKVXARJEN-FXAWDEMLSA-N 676233 US20240166635, Example 7a Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676233&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089991 500592001 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415347 CC1(COc2nc(NC3CCN(CC3)S(=O)(=O)c3cn[nH]c3)ncc2C#N)CCCC1 InChI=1S/C20H27N7O3S/c1-20(6-2-3-7-20)14-30-18-15(10-21)11-22-19(26-18)25-16-4-8-27(9-5-16)31(28,29)17-12-23-24-13-17/h11-13,16H,2-9,14H2,1H3,(H,23,24)(H,22,25,26) LRSWKUYIXWJVFN-UHFFFAOYSA-N 676245 US20240166635, Example 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676245&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090004 500592013 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416012 OC1CCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CC2)ncc1C(F)(F)F InChI=1S/C19H21F3N4O4S/c20-19(21,22)14-10-23-18(25-17(14)30-16-3-1-2-15(16)27)24-11-6-8-13(9-7-11)31(28,29)26-12-4-5-12/h6-10,12,15-16,26-27H,1-5H2,(H,23,24,25) PPASDCICDCXUJF-UHFFFAOYSA-N 676397 US20240166635, Example 107a::US20240166635, Example 107b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090352 500592126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416015 OC1CCCC1Oc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CC2)ncc1C(F)(F)F InChI=1S/C19H21F3N4O4S/c20-19(21,22)14-10-23-18(25-17(14)30-16-3-1-2-15(16)27)24-11-6-8-13(9-7-11)31(28,29)26-12-4-5-12/h6-10,12,15-16,26-27H,1-5H2,(H,23,24,25) PPASDCICDCXUJF-UHFFFAOYSA-N 676397 US20240166635, Example 107a::US20240166635, Example 107b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676397&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090352 500592126 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416021 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O3S/c1-21-28(25,26)13-8-6-11(7-9-13)23-16-22-10-14(17(18,19)20)15(24-16)27-12-4-2-3-5-12/h6-10,12,21H,2-5H2,1H3,(H,22,23,24) OURKCQIQALLKJV-UHFFFAOYSA-N 676399 US20240166635, Example 108 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676399&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990665 500592127 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416027 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c1-21-29(26,27)11-7-5-10(6-8-11)23-16-22-9-12(17(18,19)20)15(24-16)28-14-4-2-3-13(14)25/h5-9,13-14,21,25H,2-4H2,1H3,(H,22,23,24) ARZCNFVGTWMROY-UHFFFAOYSA-N 676393 US20240166635, Example 105a::US20240166635, Example 105b::US20240166635, Example 109a::US20240166635, Example 109b::US20240166635, Example 110a::US20240166635, Example 110b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090112 500592124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416030 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c1-21-29(26,27)11-7-5-10(6-8-11)23-16-22-9-12(17(18,19)20)15(24-16)28-14-4-2-3-13(14)25/h5-9,13-14,21,25H,2-4H2,1H3,(H,22,23,24) ARZCNFVGTWMROY-UHFFFAOYSA-N 676393 US20240166635, Example 105a::US20240166635, Example 105b::US20240166635, Example 109a::US20240166635, Example 109b::US20240166635, Example 110a::US20240166635, Example 110b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090112 500592124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416036 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c1-21-29(26,27)11-7-5-10(6-8-11)23-16-22-9-12(17(18,19)20)15(24-16)28-14-4-2-3-13(14)25/h5-9,13-14,21,25H,2-4H2,1H3,(H,22,23,24) ARZCNFVGTWMROY-UHFFFAOYSA-N 676393 US20240166635, Example 105a::US20240166635, Example 105b::US20240166635, Example 109a::US20240166635, Example 109b::US20240166635, Example 110a::US20240166635, Example 110b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090112 500592124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416039 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c1-21-29(26,27)11-7-5-10(6-8-11)23-16-22-9-12(17(18,19)20)15(24-16)28-14-4-2-3-13(14)25/h5-9,13-14,21,25H,2-4H2,1H3,(H,22,23,24) ARZCNFVGTWMROY-UHFFFAOYSA-N 676393 US20240166635, Example 105a::US20240166635, Example 105b::US20240166635, Example 109a::US20240166635, Example 109b::US20240166635, Example 110a::US20240166635, Example 110b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676393&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090112 500592124 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416042 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c18-17(19,20)12-9-22-16(23-10-5-7-11(8-6-10)29(21,26)27)24-15(12)28-14-4-2-1-3-13(14)25/h5-9,13-14,25H,1-4H2,(H2,21,26,27)(H,22,23,24) ZWWQVYKYWCWYFJ-UHFFFAOYSA-N 676404 US20240166635, Example 111a::US20240166635, Example 111b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090243 500592128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416048 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O4S/c18-17(19,20)12-9-22-16(23-10-5-7-11(8-6-10)29(21,26)27)24-15(12)28-14-4-2-1-3-13(14)25/h5-9,13-14,25H,1-4H2,(H2,21,26,27)(H,22,23,24) ZWWQVYKYWCWYFJ-UHFFFAOYSA-N 676404 US20240166635, Example 111a::US20240166635, Example 111b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676404&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090243 500592128 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416054 CC1CCCC(O)C1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C(F)(F)F InChI=1S/C18H21F3N4O4S/c1-10-3-2-4-14(26)15(10)29-16-13(18(19,20)21)9-23-17(25-16)24-11-5-7-12(8-6-11)30(22,27)28/h5-10,14-15,26H,2-4H2,1H3,(H2,22,27,28)(H,23,24,25) VGDVUMYVXOQBNE-UHFFFAOYSA-N 676406 US20240166635, Example 112a::US20240166635, Example 112b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090018 500592129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415353 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OCC3CCC3)n2)cc1 InChI=1S/C16H17N5O3S/c17-8-12-9-19-16(21-15(12)24-10-11-2-1-3-11)20-13-4-6-14(7-5-13)25(18,22)23/h4-7,9,11H,1-3,10H2,(H2,18,22,23)(H,19,20,21) TZUUUOFIEZNZEI-UHFFFAOYSA-N 676246 US20240166635, Example 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676246&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090216 500592014 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415359 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3)n2)cc1 InChI=1S/C16H17N5O3S/c17-9-11-10-19-16(21-15(11)24-13-3-1-2-4-13)20-12-5-7-14(8-6-12)25(18,22)23/h5-8,10,13H,1-4H2,(H2,18,22,23)(H,19,20,21) VEZGUWKKHGUXIU-UHFFFAOYSA-N 676248 US20240166635, Example 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676248&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090214 500592016 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415362 CC1CCCC1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C#N InChI=1S/C17H19N5O3S/c1-11-3-2-4-15(11)25-16-12(9-18)10-20-17(22-16)21-13-5-7-14(8-6-13)26(19,23)24/h5-8,10-11,15H,2-4H2,1H3,(H2,19,23,24)(H,20,21,22) XKOGDPYTYIFLKP-UHFFFAOYSA-N 676249 US20240166635, Example 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676249&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089931 500592017 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415368 CC1(COc2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc2C#N)CCCC1 InChI=1S/C18H21N5O3S/c1-18(8-2-3-9-18)12-26-16-13(10-19)11-21-17(23-16)22-14-4-6-15(7-5-14)27(20,24)25/h4-7,11H,2-3,8-9,12H2,1H3,(H2,20,24,25)(H,21,22,23) ULVXDRPXXHOYNY-UHFFFAOYSA-N 676250 US20240166635, Example 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676250&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090211 500592018 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415375 CC1(COc2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc2C#N)CCCCC1 InChI=1S/C19H23N5O3S/c1-19(9-3-2-4-10-19)13-27-17-14(11-20)12-22-18(24-17)23-15-5-7-16(8-6-15)28(21,25)26/h5-8,12H,2-4,9-10,13H2,1H3,(H2,21,25,26)(H,22,23,24) KBMATRHLMSLNLI-UHFFFAOYSA-N 676252 US20240166635, Example 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676252&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090218 500592020 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415380 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OCC3(CO)CCCC3)n2)cc1 InChI=1S/C18H21N5O4S/c19-9-13-10-21-17(22-14-3-5-15(6-4-14)28(20,25)26)23-16(13)27-12-18(11-24)7-1-2-8-18/h3-6,10,24H,1-2,7-8,11-12H2,(H2,20,25,26)(H,21,22,23) JDUIELGVEPIVMG-UHFFFAOYSA-N 676253 US20240166635, Example 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676253&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090221 500592021 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415387 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OCC3(CO)CCCCC3)n2)cc1 InChI=1S/C19H23N5O4S/c20-10-14-11-22-18(23-15-4-6-16(7-5-15)29(21,26)27)24-17(14)28-13-19(12-25)8-2-1-3-9-19/h4-7,11,25H,1-3,8-9,12-13H2,(H2,21,26,27)(H,22,23,24) VOYJSPOKUPFXBV-UHFFFAOYSA-N 676255 US20240166635, Example 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676255&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090212 500592023 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415390 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3CO)n2)cc1 InChI=1S/C17H19N5O4S/c18-8-12-9-20-17(21-13-4-6-14(7-5-13)27(19,24)25)22-16(12)26-15-3-1-2-11(15)10-23/h4-7,9,11,15,23H,1-3,10H2,(H2,19,24,25)(H,20,21,22) QRMZOBLILPEPAD-UHFFFAOYSA-N 676256 US20240166635, Example 18a::US20240166635, Example 18b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676256&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090241 500592024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415393 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OC3CCCC3CO)n2)cc1 InChI=1S/C17H19N5O4S/c18-8-12-9-20-17(21-13-4-6-14(7-5-13)27(19,24)25)22-16(12)26-15-3-1-2-11(15)10-23/h4-7,9,11,15,23H,1-3,10H2,(H2,19,24,25)(H,20,21,22) QRMZOBLILPEPAD-UHFFFAOYSA-N 676256 US20240166635, Example 18a::US20240166635, Example 18b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676256&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090241 500592024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415396 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(OCC3CCCC3O)n2)cc1 InChI=1S/C17H19N5O4S/c18-8-12-9-20-17(21-13-4-6-14(7-5-13)27(19,24)25)22-16(12)26-10-11-2-1-3-15(11)23/h4-7,9,11,15,23H,1-3,10H2,(H2,19,24,25)(H,20,21,22) IWWGENVVEPICMF-UHFFFAOYSA-N 676260 US20240166635, Example 19a::US20240166635, Example 19b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676260&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090242 500592025 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415842 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCC[C@H](F)C2)cc1 InChI=1S/C16H17FN6O2S/c17-12-2-1-7-23(10-12)15-11(8-18)9-20-16(22-15)21-13-3-5-14(6-4-13)26(19,24)25/h3-6,9,12H,1-2,7,10H2,(H2,19,24,25)(H,20,21,22)/t12-/m0/s1 NHURAJZSHKFCNL-LBPRGKRZSA-N 676361 US20240166635, Example 81 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676361&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090016 500592095 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1415848 NS(=O)(=O)c1ccc(Nc2ncc(C#N)c(n2)N2CCC(O)CC2)cc1 InChI=1S/C16H18N6O3S/c17-9-11-10-19-16(21-15(11)22-7-5-13(23)6-8-22)20-12-1-3-14(4-2-12)26(18,24)25/h1-4,10,13,23H,5-8H2,(H2,18,24,25)(H,19,20,21) YLLBIPKMNYSIAV-UHFFFAOYSA-N 676362 US20240166635, Example 82 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676362&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090014 500592096 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416057 CC1CCCC(O)C1Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1C(F)(F)F InChI=1S/C18H21F3N4O4S/c1-10-3-2-4-14(26)15(10)29-16-13(18(19,20)21)9-23-17(25-16)24-11-5-7-12(8-6-11)30(22,27)28/h5-10,14-15,26H,2-4H2,1H3,(H2,22,27,28)(H,23,24,25) VGDVUMYVXOQBNE-UHFFFAOYSA-N 676406 US20240166635, Example 112a::US20240166635, Example 112b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676406&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090018 500592129 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416060 NS(=O)(=O)c1ccc(Nc2ncc(c(O[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C18H19F3N4O4S/c19-18(20,21)13-8-23-17(24-11-3-5-12(6-4-11)30(22,27)28)25-16(13)29-15-10-2-1-9(7-10)14(15)26/h3-6,8-10,14-15,26H,1-2,7H2,(H2,22,27,28)(H,23,24,25)/t9-,10+,14+,15-/m0/s1 LAOPYJXRBUECEH-RZCHIYRCSA-N 676408 US20240166635, Example 113a::US20240166635, Example 113b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090080 500592130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416063 NS(=O)(=O)c1ccc(Nc2ncc(c(O[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3O)n2)C(F)(F)F)cc1 InChI=1S/C18H19F3N4O4S/c19-18(20,21)13-8-23-17(24-11-3-5-12(6-4-11)30(22,27)28)25-16(13)29-15-10-2-1-9(7-10)14(15)26/h3-6,8-10,14-15,26H,1-2,7H2,(H2,22,27,28)(H,23,24,25)/t9-,10+,14+,15-/m0/s1 LAOPYJXRBUECEH-RZCHIYRCSA-N 676408 US20240166635, Example 113a::US20240166635, Example 113b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676408&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090080 500592130 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416069 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCOCC3O)n2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O5S/c17-16(18,19)11-7-21-15(22-9-1-3-10(4-2-9)29(20,25)26)23-14(11)28-13-5-6-27-8-12(13)24/h1-4,7,12-13,24H,5-6,8H2,(H2,20,25,26)(H,21,22,23) PYWQHGIYYMEYGG-UHFFFAOYSA-N 676410 US20240166635, Example 114a::US20240166635, Example 114b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 55 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090335 500592131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416072 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCOCC3O)n2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O5S/c17-16(18,19)11-7-21-15(22-9-1-3-10(4-2-9)29(20,25)26)23-14(11)28-13-5-6-27-8-12(13)24/h1-4,7,12-13,24H,5-6,8H2,(H2,20,25,26)(H,21,22,23) PYWQHGIYYMEYGG-UHFFFAOYSA-N 676410 US20240166635, Example 114a::US20240166635, Example 114b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676410&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167090335 500592131 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416078 NS(=O)(=O)c1ccc(Nc2ncc(c(OC3COCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O5S/c17-16(18,19)11-7-21-15(22-9-1-3-10(4-2-9)29(20,25)26)23-14(11)28-13-8-27-6-5-12(13)24/h1-4,7,12-13,24H,5-6,8H2,(H2,20,25,26)(H,21,22,23) WRWISRXAEHTYJK-UHFFFAOYSA-N 676412 US20240166635, Example 115a::US20240166635, Example 115b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676412&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089957 500592132 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416084 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCOCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O5S/c1-21-30(26,27)11-4-2-10(3-5-11)23-16-22-8-12(17(18,19)20)15(24-16)29-14-6-7-28-9-13(14)25/h2-5,8,13-14,21,25H,6-7,9H2,1H3,(H,22,23,24) PCCSUZXFRYBZTH-UHFFFAOYSA-N 676414 US20240166635, Example 116a::US20240166635, Example 116b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676414&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089956 500592133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416087 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCOCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O5S/c1-21-30(26,27)11-4-2-10(3-5-11)23-16-22-8-12(17(18,19)20)15(24-16)29-14-6-7-28-9-13(14)25/h2-5,8,13-14,21,25H,6-7,9H2,1H3,(H,22,23,24) PCCSUZXFRYBZTH-UHFFFAOYSA-N 676414 US20240166635, Example 116a::US20240166635, Example 116b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676414&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167089956 500592133 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416093 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3COCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O5S/c1-21-30(26,27)11-4-2-10(3-5-11)23-16-22-8-12(17(18,19)20)15(24-16)29-14-9-28-7-6-13(14)25/h2-5,8,13-14,21,25H,6-7,9H2,1H3,(H,22,23,24) VOMODKIWVHCAIR-UHFFFAOYSA-N 676416 US20240166635, Example 117a::US20240166635, Example 117b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 550 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676416&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990666 500592134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1416096 CNS(=O)(=O)c1ccc(Nc2ncc(c(OC3COCCC3O)n2)C(F)(F)F)cc1 InChI=1S/C17H19F3N4O5S/c1-21-30(26,27)11-4-2-10(3-5-11)23-16-22-8-12(17(18,19)20)15(24-16)29-14-9-28-7-6-13(14)25/h2-5,8,13-14,21,25H,6-7,9H2,1H3,(H,22,23,24) VOMODKIWVHCAIR-UHFFFAOYSA-N 676416 US20240166635, Example 117a::US20240166635, Example 117b Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2GM8CMT US20240166635 Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z Anrui Biomedical Technology (Guangzhou) Co.,Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=676416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=676416&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171990666 500592134 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411873 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US11643416, Compound 1::US20240150369, Compound 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.40 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411878 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 2::US20240150369, Compound 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.50 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411883 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 3::US20240150369, Compound 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411888 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 4::US20240150369, Compound 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411893 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 12::US20240150369, Compound 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411898 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m0/s1 FKAJEPVSQITQLJ-INIZCTEOSA-N 601938 (R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 18::US20240150369, Compound 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411903 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26)/t13-/m0/s1 ZJKDYTFNXUBLEQ-ZDUSSCGKSA-N 601939 (S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 19::US20240150369, Compound 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411908 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 5::US20240150369, Compound 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411913 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m1/s1 FKAJEPVSQITQLJ-MRXNPFEDSA-N 601941 (S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 23::US20240150369, Compound 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411918 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 42::US20240150369, Compound 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411923 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 43::US20240150369, Compound 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411928 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 45::US20240150369, Compound 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411933 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 46::US20240150369, Compound 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411938 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 49::US20240150369, Compound 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 199 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411943 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 50::US20240150369, Compound 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411948 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 51::US20240150369, Compound 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411953 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 52::US20240150369, Compound 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 318 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411958 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 53::US20240150369, Compound 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411963 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 54::US20240150369, Compound 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411968 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US11643416, Compound 55::US20240150369, Compound 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411973 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 59::US20240150369, Compound 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411978 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 61::US20240150369, Compound 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411983 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 62::US20240150369, Compound 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 398 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411988 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 63::US20240150369, Compound 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 118 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411993 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 64::US20240150369, Compound 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1411998 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US11643416, Compound 68::US20240150369, Compound 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 284 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1412003 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 71::US20240150369, Compound 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1412008 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 74::US20240150369, Compound 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 653 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1412013 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 79::US20240150369, Compound 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1412018 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US11643416, Compound 84::US20240150369, Compound 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1412023 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US11643416, Compound 91::US20240150369, Compound 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 183 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396164 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)C(C1CC1)C1CC1 InChI=1S/C18H25N5/c19-13-5-6-14(9-13)21-17-10-15(22-16-7-8-20-23(16)17)18(11-1-2-11)12-3-4-12/h7-8,10-14,18,21H,1-6,9,19H2/t13-,14-/m0/s1 KYGRRMHGNQPSHN-KBPBESRZSA-N 663074 US20240109898, Compound Z-1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663074&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396165 N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(Cl)cnn12)C(C1CC1)C1CC1 InChI=1S/C18H24ClN5/c19-14-9-21-24-16(22-13-6-5-12(20)7-13)8-15(23-18(14)24)17(10-1-2-10)11-3-4-11/h8-13,17,22H,1-7,20H2/t12-,13-/m0/s1 SFTUTTCEFHKFNF-STQMWFEESA-N 663075 US20240109898, Compound Z-2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663075&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396166 N[C@H]1CC[C@@H](C1)Nc1cc(CC2CC2)nc2ccnn12 InChI=1S/C15H21N5/c16-11-3-4-12(8-11)18-15-9-13(7-10-1-2-10)19-14-5-6-17-20(14)15/h5-6,9-12,18H,1-4,7-8,16H2/t11-,12-/m0/s1 LMHPCXKNISVYLM-RYUDHWBXSA-N 663076 US20240109898, Compound Z-3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 73.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663076&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396167 N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(cnn12)C#N)C(C1CC1)C1CC1 InChI=1S/C19H24N6/c20-9-13-10-22-25-17(23-15-6-5-14(21)7-15)8-16(24-19(13)25)18(11-1-2-11)12-3-4-12/h8,10-12,14-15,18,23H,1-7,21H2/t14-,15-/m0/s1 NEXNKMPOCOPVBN-GJZGRUSLSA-N 663077 US20240109898, Compound Z-4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663077&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396168 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H23N5/c1-10(11-2-3-11)14-9-16(19-13-5-4-12(17)8-13)21-15(20-14)6-7-18-21/h6-7,9-13,19H,2-5,8,17H2,1H3/t10?,12-,13-/m0/s1 SZWIEOISRBXPJU-OLPBLLBXSA-N 663078 US20240109898, Compound Z-5::US20240109898, Compound Z-5-1::US20240109898, Compound Z-5-2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663078&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396169 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H23N5/c1-10(11-2-3-11)14-9-16(19-13-5-4-12(17)8-13)21-15(20-14)6-7-18-21/h6-7,9-13,19H,2-5,8,17H2,1H3/t10?,12-,13-/m0/s1 SZWIEOISRBXPJU-OLPBLLBXSA-N 663078 US20240109898, Compound Z-5::US20240109898, Compound Z-5-1::US20240109898, Compound Z-5-2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663078&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396170 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H23N5/c1-10(11-2-3-11)14-9-16(19-13-5-4-12(17)8-13)21-15(20-14)6-7-18-21/h6-7,9-13,19H,2-5,8,17H2,1H3/t10?,12-,13-/m0/s1 SZWIEOISRBXPJU-OLPBLLBXSA-N 663078 US20240109898, Compound Z-5::US20240109898, Compound Z-5-1::US20240109898, Compound Z-5-2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663078&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396171 Cc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C1CC1)C1CC1 InChI=1S/C19H27N5/c1-11-10-21-24-17(22-15-7-6-14(20)8-15)9-16(23-19(11)24)18(12-2-3-12)13-4-5-13/h9-10,12-15,18,22H,2-8,20H2,1H3/t14-,15-/m0/s1 OVNZFFBLWDETLK-GJZGRUSLSA-N 663081 US20240109898, Compound Z-9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663081&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396172 CC(C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-11(12-3-2-4-12)15-10-17(20-14-6-5-13(18)9-14)22-16(21-15)7-8-19-22/h7-8,10-14,20H,2-6,9,18H2,1H3/t11?,13-,14-/m0/s1 AZVNRRDTFPTXQQ-VNXPTHQBSA-N 663082 US20240109898, Compound Z-11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663082&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396173 C[C@@H](C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-11(12-3-2-4-12)15-10-17(20-14-6-5-13(18)9-14)22-16(21-15)7-8-19-22/h7-8,10-14,20H,2-6,9,18H2,1H3/t11-,13-,14-/m0/s1 AZVNRRDTFPTXQQ-UBHSHLNASA-N 663083 US20240109898, Compound Z-11-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663083&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396174 C[C@H](C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-11(12-3-2-4-12)15-10-17(20-14-6-5-13(18)9-14)22-16(21-15)7-8-19-22/h7-8,10-14,20H,2-6,9,18H2,1H3/t11-,13+,14+/m1/s1 AZVNRRDTFPTXQQ-XBFCOCLRSA-N 663084 US20240109898, Compound Z-11-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663084&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396175 CC(C)(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-17(2,11-3-4-11)14-10-16(20-13-6-5-12(18)9-13)22-15(21-14)7-8-19-22/h7-8,10-13,20H,3-6,9,18H2,1-2H3/t12-,13-/m0/s1 PYYKVRVBYYIMHW-STQMWFEESA-N 663085 US20240109898, Compound Z-12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663085&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396176 CC(C1CCCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C18H27N5/c1-12(13-4-2-3-5-13)16-11-18(21-15-7-6-14(19)10-15)23-17(22-16)8-9-20-23/h8-9,11-15,21H,2-7,10,19H2,1H3/t12?,14-,15-/m0/s1 FXPNDXYHOREMNE-ZRNAQANOSA-N 663086 US20240109898, Compound Z-13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663086&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396177 N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(cnn12)C1CC1)C(C1CC1)C1CC1 InChI=1S/C21H29N5/c22-15-7-8-16(9-15)24-19-10-18(20(13-3-4-13)14-5-6-14)25-21-17(12-1-2-12)11-23-26(19)21/h10-16,20,24H,1-9,22H2/t15-,16-/m0/s1 ISKJPECRAUXMRV-HOTGVXAUSA-N 663087 US20240109898, Compound Z-14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663087&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396178 N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(F)cnn12)C(C1CC1)C1CC1 InChI=1S/C18H24FN5/c19-14-9-21-24-16(22-13-6-5-12(20)7-13)8-15(23-18(14)24)17(10-1-2-10)11-3-4-11/h8-13,17,22H,1-7,20H2/t12-,13-/m0/s1 LWYOYMDGSBDNLO-STQMWFEESA-N 663088 US20240109898, Compound Z-15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663088&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396179 CCc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C1CC1)C1CC1 InChI=1S/C20H29N5/c1-2-12-11-22-25-18(23-16-8-7-15(21)9-16)10-17(24-20(12)25)19(13-3-4-13)14-5-6-14/h10-11,13-16,19,23H,2-9,21H2,1H3/t15-,16-/m0/s1 CANMYMPJEYNUMN-HOTGVXAUSA-N 663089 US20240109898, Compound Z-16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663089&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396180 CC1(Cc2cc(N[C@H]3CC[C@H](N)C3)n3nccc3n2)CC1 InChI=1S/C16H23N5/c1-16(5-6-16)10-13-9-15(19-12-3-2-11(17)8-12)21-14(20-13)4-7-18-21/h4,7,9,11-12,19H,2-3,5-6,8,10,17H2,1H3/t11-,12-/m0/s1 CQNDEDLTYOMSMP-RYUDHWBXSA-N 663090 US20240109898, Compound Z-17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 60.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663090&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396181 CC(C)(C=C)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H23N5/c1-4-16(2,3)13-10-15(19-12-6-5-11(17)9-12)21-14(20-13)7-8-18-21/h4,7-8,10-12,19H,1,5-6,9,17H2,2-3H3/t11-,12-/m0/s1 OBCABHMDELSCSE-RYUDHWBXSA-N 663091 US20240109898, Compound Z-18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663091&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396182 Cc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C)(C)C=C InChI=1S/C17H25N5/c1-5-17(3,4)14-9-15(20-13-7-6-12(18)8-13)22-16(21-14)11(2)10-19-22/h5,9-10,12-13,20H,1,6-8,18H2,2-4H3/t12-,13-/m0/s1 AISOGQCCHNYKDL-STQMWFEESA-N 663092 US20240109898, Compound Z-19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 92.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663092&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396183 CCc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C)C1CC1 InChI=1S/C18H27N5/c1-3-12-10-20-23-17(21-15-7-6-14(19)8-15)9-16(22-18(12)23)11(2)13-4-5-13/h9-11,13-15,21H,3-8,19H2,1-2H3/t11?,14-,15-/m0/s1 KQVNOUGDDKDEPG-CNSWMUILSA-N 663093 US20240109898, Compound Z-20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663093&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396184 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)CC2)n2nccc2n1 InChI=1S/C17H25N5/c1-11(12-2-3-12)15-10-17(22-16(21-15)8-9-19-22)20-14-6-4-13(18)5-7-14/h8-14,20H,2-7,18H2,1H3/t11?,13-,14- XNFIQLNYVDKWDX-RCWADLFESA-N 663094 US20240109898, Compound Z-21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663094&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396185 CC(C1CC1)(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C19H27N5/c1-19(12-2-3-12,13-4-5-13)16-11-18(22-15-7-6-14(20)10-15)24-17(23-16)8-9-21-24/h8-9,11-15,22H,2-7,10,20H2,1H3/t14-,15-/m0/s1 MQKKNPBBRANNDW-GJZGRUSLSA-N 663095 US20240109898, Compound Z-22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663095&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396186 N[C@H]1CC[C@@H](C1)Nc1cc(CC2CC(F)(F)C2)nc2ccnn12 InChI=1S/C16H21F2N5/c17-16(18)8-10(9-16)5-13-7-15(21-12-2-1-11(19)6-12)23-14(22-13)3-4-20-23/h3-4,7,10-12,21H,1-2,5-6,8-9,19H2/t11-,12-/m0/s1 FZWXFVKKWLRQSN-RYUDHWBXSA-N 663096 US20240109898, Compound Z-24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663096&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396187 CC(C)c1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C1CC1)C1CC1 InChI=1S/C21H31N5/c1-12(2)17-11-23-26-19(24-16-8-7-15(22)9-16)10-18(25-21(17)26)20(13-3-4-13)14-5-6-14/h10-16,20,24H,3-9,22H2,1-2H3/t15-,16-/m0/s1 UKDAHPHGAWEIMM-HOTGVXAUSA-N 663097 US20240109898, Compound Z-25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663097&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396188 CC(c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1)C1(C)CC1 InChI=1S/C18H27N5/c1-11-10-20-23-16(21-14-5-4-13(19)8-14)9-15(22-17(11)23)12(2)18(3)6-7-18/h9-10,12-14,21H,4-8,19H2,1-3H3/t12?,13-,14-/m0/s1 KCEPBMBDWHJPCB-TTZKSVMKSA-N 663098 US20240109898, Compound Z-26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663098&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396189 C[C@@H](c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1)C1(C)CC1 InChI=1S/C18H27N5/c1-11-10-20-23-16(21-14-5-4-13(19)8-14)9-15(22-17(11)23)12(2)18(3)6-7-18/h9-10,12-14,21H,4-8,19H2,1-3H3/t12-,13-,14-/m0/s1 KCEPBMBDWHJPCB-IHRRRGAJSA-N 663099 US20240109898, Compound Z-26-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663099&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396190 C[C@H](c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1)C1(C)CC1 InChI=1S/C18H27N5/c1-11-10-20-23-16(21-14-5-4-13(19)8-14)9-15(22-17(11)23)12(2)18(3)6-7-18/h9-10,12-14,21H,4-8,19H2,1-3H3/t12-,13+,14+/m1/s1 KCEPBMBDWHJPCB-RDBSUJKOSA-N 663100 US20240109898, Compound Z-26-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 78.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663100&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396191 CC(c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1)C1(C)CC1 InChI=1S/C17H25N5/c1-11(17(2)6-7-17)14-10-16(20-13-4-3-12(18)9-13)22-15(21-14)5-8-19-22/h5,8,10-13,20H,3-4,6-7,9,18H2,1-2H3/t11?,12-,13-/m0/s1 XSPHSKJQNCIDLI-SPOOISQMSA-N 663101 US20240109898, Compound Z-27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663101&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396192 C[C@@H](c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1)C1(C)CC1 InChI=1S/C17H25N5/c1-11(17(2)6-7-17)14-10-16(20-13-4-3-12(18)9-13)22-15(21-14)5-8-19-22/h5,8,10-13,20H,3-4,6-7,9,18H2,1-2H3/t11-,12-,13-/m0/s1 XSPHSKJQNCIDLI-AVGNSLFASA-N 663102 US20240109898, Compound Z-27-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663102&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396193 C[C@H](c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1)C1(C)CC1 InChI=1S/C17H25N5/c1-11(17(2)6-7-17)14-10-16(20-13-4-3-12(18)9-13)22-15(21-14)5-8-19-22/h5,8,10-13,20H,3-4,6-7,9,18H2,1-2H3/t11-,12+,13+/m1/s1 XSPHSKJQNCIDLI-AGIUHOORSA-N 663103 US20240109898, Compound Z-27-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663103&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396194 CCC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-2-14(11-3-4-11)15-10-17(20-13-6-5-12(18)9-13)22-16(21-15)7-8-19-22/h7-8,10-14,20H,2-6,9,18H2,1H3/t12-,13-,14?/m0/s1 LQDHNDQPGBTBEI-RFHHWMCGSA-N 663104 US20240109898, Compound Z-28 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663104&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396195 CC[C@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-2-14(11-3-4-11)15-10-17(20-13-6-5-12(18)9-13)22-16(21-15)7-8-19-22/h7-8,10-14,20H,2-6,9,18H2,1H3/t12-,13-,14+/m0/s1 LQDHNDQPGBTBEI-MELADBBJSA-N 663105 US20240109898, Compound Z-28-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663105&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396196 CC[C@@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-2-14(11-3-4-11)15-10-17(20-13-6-5-12(18)9-13)22-16(21-15)7-8-19-22/h7-8,10-14,20H,2-6,9,18H2,1H3/t12-,13-,14-/m0/s1 LQDHNDQPGBTBEI-IHRRRGAJSA-N 663106 US20240109898, Compound Z-28-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 12.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663106&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396197 CC1(Cc2cc(N[C@H]3CC[C@H](N)C3)n3ncc(Cl)c3n2)CC1 InChI=1S/C16H22ClN5/c1-16(4-5-16)8-12-7-14(20-11-3-2-10(18)6-11)22-15(21-12)13(17)9-19-22/h7,9-11,20H,2-6,8,18H2,1H3/t10-,11-/m0/s1 FLQOFHFOYKMWND-QWRGUYRKSA-N 663107 US20240109898, Compound Z-29 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663107&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396198 CCC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C18H27N5/c1-3-15(12-4-5-12)16-9-17(21-14-7-6-13(19)8-14)23-18(22-16)11(2)10-20-23/h9-10,12-15,21H,3-8,19H2,1-2H3/t13-,14-,15?/m0/s1 ROFSYQKVAKNARS-ZYOSVBKOSA-N 663108 US20240109898, Compound Z-30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663108&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396199 CC[C@@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C18H27N5/c1-3-15(12-4-5-12)16-9-17(21-14-7-6-13(19)8-14)23-18(22-16)11(2)10-20-23/h9-10,12-15,21H,3-8,19H2,1-2H3/t13-,14-,15-/m0/s1 ROFSYQKVAKNARS-KKUMJFAQSA-N 663109 US20240109898, Compound Z-30-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663109&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396200 CC[C@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C18H27N5/c1-3-15(12-4-5-12)16-9-17(21-14-7-6-13(19)8-14)23-18(22-16)11(2)10-20-23/h9-10,12-15,21H,3-8,19H2,1-2H3/t13-,14-,15+/m0/s1 ROFSYQKVAKNARS-SOUVJXGZSA-N 663110 US20240109898, Compound Z-30-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663110&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396201 CC(C1CC1)c1cc(NC2CCNC2)n2ncc(F)c2n1 InChI=1S/C15H20FN5/c1-9(10-2-3-10)13-6-14(19-11-4-5-17-7-11)21-15(20-13)12(16)8-18-21/h6,8-11,17,19H,2-5,7H2,1H3 SVGIEQINKZNWGC-UHFFFAOYSA-N 663111 US20240109898, Compound Z-31 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 104 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663111&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396202 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C17H25N5/c1-10-9-19-22-16(20-14-6-5-13(18)7-14)8-15(21-17(10)22)11(2)12-3-4-12/h8-9,11-14,20H,3-7,18H2,1-2H3/t11?,13-,14-/m0/s1 RRJKIYJZTYQTKJ-VNXPTHQBSA-N 663112 US20240109898, Compound Z-32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663112&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396203 C[C@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C17H25N5/c1-10-9-19-22-16(20-14-6-5-13(18)7-14)8-15(21-17(10)22)11(2)12-3-4-12/h8-9,11-14,20H,3-7,18H2,1-2H3/t11-,13+,14+/m1/s1 RRJKIYJZTYQTKJ-XBFCOCLRSA-N 663113 US20240109898, Compound Z-32-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 99.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663113&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396204 C[C@@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C17H25N5/c1-10-9-19-22-16(20-14-6-5-13(18)7-14)8-15(21-17(10)22)11(2)12-3-4-12/h8-9,11-14,20H,3-7,18H2,1-2H3/t11-,13-,14-/m0/s1 RRJKIYJZTYQTKJ-UBHSHLNASA-N 663114 US20240109898, Compound Z-32-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663114&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396205 N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(cnn12)C(F)(F)F)C(C1CC1)C1CC1 InChI=1S/C19H24F3N5/c20-19(21,22)14-9-24-27-16(25-13-6-5-12(23)7-13)8-15(26-18(14)27)17(10-1-2-10)11-3-4-11/h8-13,17,25H,1-7,23H2/t12-,13-/m0/s1 NJPIZAROFOGVAA-STQMWFEESA-N 663115 US20240109898, Compound Z-33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663115&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396206 Cc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C)(C)C1CC1 InChI=1S/C18H27N5/c1-11-10-20-23-16(21-14-7-6-13(19)8-14)9-15(22-17(11)23)18(2,3)12-4-5-12/h9-10,12-14,21H,4-8,19H2,1-3H3/t13-,14-/m0/s1 IZNNAUJOJAQVGV-KBPBESRZSA-N 663116 US20240109898, Compound Z-34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663116&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396207 CC(C)(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C17H24ClN5/c1-17(2,10-3-4-10)14-8-15(21-12-6-5-11(19)7-12)23-16(22-14)13(18)9-20-23/h8-12,21H,3-7,19H2,1-2H3/t11-,12-/m0/s1 OURBYDFOHRDGRG-RYUDHWBXSA-N 663117 US20240109898, Compound Z-35 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663117&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396208 CC(C)(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(F)c2n1 InChI=1S/C17H24FN5/c1-17(2,10-3-4-10)14-8-15(21-12-6-5-11(19)7-12)23-16(22-14)13(18)9-20-23/h8-12,21H,3-7,19H2,1-2H3/t11-,12-/m0/s1 SKLWAPCDIJWVBF-RYUDHWBXSA-N 663118 US20240109898, Compound Z-36 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663118&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396209 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)C(F)(F)C1CC1 InChI=1S/C15H19F2N5/c16-15(17,9-1-2-9)12-8-14(20-11-4-3-10(18)7-11)22-13(21-12)5-6-19-22/h5-6,8-11,20H,1-4,7,18H2/t10-,11-/m0/s1 XFNNLTKFDQVGOW-QWRGUYRKSA-N 663119 US20240109898, Compound Z-37 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663119&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396210 CC(C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C18H27N5/c1-11-10-20-23-17(21-15-7-6-14(19)8-15)9-16(22-18(11)23)12(2)13-4-3-5-13/h9-10,12-15,21H,3-8,19H2,1-2H3/t12?,14-,15-/m0/s1 UGOBYSYMRPWLPU-ZRNAQANOSA-N 663120 US20240109898, Compound Z-38 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663120&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396211 C[C@H](C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C18H27N5/c1-11-10-20-23-17(21-15-7-6-14(19)8-15)9-16(22-18(11)23)12(2)13-4-3-5-13/h9-10,12-15,21H,3-8,19H2,1-2H3/t12-,14+,15+/m1/s1 UGOBYSYMRPWLPU-SNPRPXQTSA-N 663121 US20240109898, Compound Z-38-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 40.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663121&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396212 C[C@@H](C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C)c2n1 InChI=1S/C18H27N5/c1-11-10-20-23-17(21-15-7-6-14(19)8-15)9-16(22-18(11)23)12(2)13-4-3-5-13/h9-10,12-15,21H,3-8,19H2,1-2H3/t12-,14-,15-/m0/s1 UGOBYSYMRPWLPU-QEJZJMRPSA-N 663122 US20240109898, Compound Z-38-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663122&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396213 CC(C)(C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C18H27N5/c1-18(2,12-4-3-5-12)15-11-17(21-14-7-6-13(19)10-14)23-16(22-15)8-9-20-23/h8-9,11-14,21H,3-7,10,19H2,1-2H3/t13-,14-/m0/s1 KKZKHQDSPARHGX-KBPBESRZSA-N 663123 US20240109898, Compound Z-39 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663123&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396214 Cc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(nc12)C(C)(C)C1CCC1 InChI=1S/C19H29N5/c1-12-11-21-24-17(22-15-8-7-14(20)9-15)10-16(23-18(12)24)19(2,3)13-5-4-6-13/h10-11,13-15,22H,4-9,20H2,1-3H3/t14-,15-/m0/s1 BIOCSYYADXWCSV-GJZGRUSLSA-N 663124 US20240109898, Compound Z-40 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 48.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663124&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396215 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)[C@@H](F)C1CCC1 InChI=1S/C16H22FN5/c17-16(10-2-1-3-10)13-9-15(20-12-5-4-11(18)8-12)22-14(21-13)6-7-19-22/h6-7,9-12,16,20H,1-5,8,18H2/t11-,12-,16-/m0/s1 VYNHLDOOJDAYEV-MKBNYLNASA-N 663125 US20240109898, Compound Z-41-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663125&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396216 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)[C@H](F)C1CCC1 InChI=1S/C16H22FN5/c17-16(10-2-1-3-10)13-9-15(20-12-5-4-11(18)8-12)22-14(21-13)6-7-19-22/h6-7,9-12,16,20H,1-5,8,18H2/t11-,12-,16+/m0/s1 VYNHLDOOJDAYEV-MQIPJXDCSA-N 663126 US20240109898, Compound Z-41-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663126&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396217 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)C(F)C1CCC1 InChI=1S/C16H22FN5/c17-16(10-2-1-3-10)13-9-15(20-12-5-4-11(18)8-12)22-14(21-13)6-7-19-22/h6-7,9-12,16,20H,1-5,8,18H2/t11-,12-,16?/m0/s1 VYNHLDOOJDAYEV-YSWZKLOHSA-N 663127 US20240109898, Compound Z-42::US20240109898, Compound Z-70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663127&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396218 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)C(F)C1CCCC1 InChI=1S/C17H24FN5/c18-17(11-3-1-2-4-11)14-10-16(21-13-6-5-12(19)9-13)23-15(22-14)7-8-20-23/h7-8,10-13,17,21H,1-6,9,19H2/t12-,13-,17?/m0/s1 BPBFPQISZUPTSE-RNWUTADCSA-N 663128 US20240109898, Compound Z-43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663128&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396219 CCC(C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C18H27N5/c1-2-15(12-4-3-5-12)16-11-18(21-14-7-6-13(19)10-14)23-17(22-16)8-9-20-23/h8-9,11-15,21H,2-7,10,19H2,1H3/t13-,14-,15?/m0/s1 IEJYFVINRIODGD-ZYOSVBKOSA-N 663129 US20240109898, Compound Z-44 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663129&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396220 CC(C)(C1CCC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C18H26ClN5/c1-18(2,11-4-3-5-11)15-9-16(22-13-7-6-12(20)8-13)24-17(23-15)14(19)10-21-24/h9-13,22H,3-8,20H2,1-2H3/t12-,13-/m0/s1 MOFWRNQPXOVBPD-STQMWFEESA-N 663130 US20240109898, Compound Z-46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663130&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396221 CC(C1CC1)c1cc(NC2CCN(N)C2)n2ncc(Cl)c2n1 InChI=1S/C15H21ClN6/c1-9(10-2-3-10)13-6-14(19-11-4-5-21(17)8-11)22-15(20-13)12(16)7-18-22/h6-7,9-11,19H,2-5,8,17H2,1H3 FWHLEWAEGOCEPJ-UHFFFAOYSA-N 663131 US20240109898, Compound Z-47 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663131&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396222 COC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C16H22ClN5O/c1-23-15(9-2-3-9)13-7-14(20-11-5-4-10(18)6-11)22-16(21-13)12(17)8-19-22/h7-11,15,20H,2-6,18H2,1H3/t10-,11-,15?/m0/s1 BXFJOGNIKHVCNA-AKABHXMESA-N 663132 US20240109898, Compound Z-48 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 68.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663132&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396223 COC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H23N5O/c1-22-16(10-2-3-10)13-9-15(19-12-5-4-11(17)8-12)21-14(20-13)6-7-18-21/h6-7,9-12,16,19H,2-5,8,17H2,1H3/t11-,12-,16?/m0/s1 OTOOEUPLHHRPBG-YSWZKLOHSA-N 663133 US20240109898, Compound Z-49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663133&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396224 N[C@H]1CC[C@@H](C1)Nc1cc(CC2CCC2)nc2ccnn12 InChI=1S/C16H23N5/c17-12-4-5-13(9-12)19-16-10-14(8-11-2-1-3-11)20-15-6-7-18-21(15)16/h6-7,10-13,19H,1-5,8-9,17H2/t12-,13-/m0/s1 ACXCKPJUTSOICY-STQMWFEESA-N 663134 US20240109898, Compound Z-50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663134&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396225 Cc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(CC3CCC3)nc12 InChI=1S/C17H25N5/c1-11-10-19-22-16(20-14-6-5-13(18)8-14)9-15(21-17(11)22)7-12-3-2-4-12/h9-10,12-14,20H,2-8,18H2,1H3/t13-,14-/m0/s1 IETBWXHBALMODZ-KBPBESRZSA-N 663135 US20240109898, Compound Z-51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 65.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663135&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396226 Cc1cnn2c(N[C@H]3CC[C@H](N)C3)cc(CC3CC3)nc12 InChI=1S/C16H23N5/c1-10-9-18-21-15(19-13-5-4-12(17)7-13)8-14(20-16(10)21)6-11-2-3-11/h8-9,11-13,19H,2-7,17H2,1H3/t12-,13-/m0/s1 SCYZSHFIHFXTOY-STQMWFEESA-N 663136 US20240109898, Compound Z-52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663136&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396227 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)C(F)C1CC1 InChI=1S/C15H20FN5/c16-15(9-1-2-9)12-8-14(19-11-4-3-10(17)7-11)21-13(20-12)5-6-18-21/h5-6,8-11,15,19H,1-4,7,17H2/t10-,11-,15?/m0/s1 RCHQHQHXOFVREZ-AKABHXMESA-N 663137 US20240109898, Compound Z-53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663137&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396228 N[C@H]1CC[C@@H](C1)Nc1cc(CC2CC2)nc2c(F)cnn12 InChI=1S/C15H20FN5/c16-13-8-18-21-14(19-11-4-3-10(17)6-11)7-12(20-15(13)21)5-9-1-2-9/h7-11,19H,1-6,17H2/t10-,11-/m0/s1 FMKGWVFGZNWBQE-QWRGUYRKSA-N 663138 US20240109898, Compound Z-54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663138&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396229 N[C@H]1CC[C@@H](C1)Nc1cc(CC2CC2)nc2c(Cl)cnn12 InChI=1S/C15H20ClN5/c16-13-8-18-21-14(19-11-4-3-10(17)6-11)7-12(20-15(13)21)5-9-1-2-9/h7-11,19H,1-6,17H2/t10-,11-/m0/s1 SMYQYBCDIWVVPC-QWRGUYRKSA-N 663139 US20240109898, Compound Z-55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663139&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396230 CC(C)(C=C)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C16H22ClN5/c1-4-16(2,3)13-8-14(20-11-6-5-10(18)7-11)22-15(21-13)12(17)9-19-22/h4,8-11,20H,1,5-7,18H2,2-3H3/t10-,11-/m0/s1 QZWZYLAAQVVGKK-QWRGUYRKSA-N 663140 US20240109898, Compound Z-56 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 13.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663140&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396231 CC(C)(CC=C)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C17H25N5/c1-4-8-17(2,3)14-11-16(20-13-6-5-12(18)10-13)22-15(21-14)7-9-19-22/h4,7,9,11-13,20H,1,5-6,8,10,18H2,2-3H3/t12-,13-/m0/s1 MKYUSOKTWQIJNW-STQMWFEESA-N 663141 US20240109898, Compound Z-57 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663141&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396232 CC(C)(C=C)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(F)c2n1 InChI=1S/C16H22FN5/c1-4-16(2,3)13-8-14(20-11-6-5-10(18)7-11)22-15(21-13)12(17)9-19-22/h4,8-11,20H,1,5-7,18H2,2-3H3/t10-,11-/m0/s1 AETPQNHMTPIPOG-QWRGUYRKSA-N 663142 US20240109898, Compound Z-58 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663142&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396233 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(C=C)c2n1 InChI=1S/C18H25N5/c1-3-12-10-20-23-17(21-15-7-6-14(19)8-15)9-16(22-18(12)23)11(2)13-4-5-13/h3,9-11,13-15,21H,1,4-8,19H2,2H3/t11?,14-,15-/m0/s1 RYEQKXQYZCPGLN-CNSWMUILSA-N 663143 US20240109898, Compound Z-60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663143&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396234 CC(=N)N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(Cl)cnn12)C(C1CC1)C1CC1 InChI=1S/C20H27ClN6/c1-11(22)24-14-6-7-15(8-14)25-18-9-17(19(12-2-3-12)13-4-5-13)26-20-16(21)10-23-27(18)20/h9-10,12-15,19,25H,2-8H2,1H3,(H2,22,24)/t14-,15-/m0/s1 KKYYPSFQBHDNKG-GJZGRUSLSA-N 663144 US20240109898, Compound Z-61::US20240109898, Compound Z-66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663144&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396235 CC(C1CC1)c1cc(N[C@H]2C[C@H](N)C2)n2nccc2n1 InChI=1S/C15H21N5/c1-9(10-2-3-10)13-8-15(18-12-6-11(16)7-12)20-14(19-13)4-5-17-20/h4-5,8-12,18H,2-3,6-7,16H2,1H3/t9?,11-,12- HFUYMWZLPNSAMG-GJHXLRIWSA-N 663145 US20240109898, Compound Z-62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 17.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663145&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396236 C[C@@H](C1CC1)c1cc(N[C@H]2C[C@H](N)C2)n2nccc2n1 InChI=1S/C15H21N5/c1-9(10-2-3-10)13-8-15(18-12-6-11(16)7-12)20-14(19-13)4-5-17-20/h4-5,8-12,18H,2-3,6-7,16H2,1H3/t9-,11-,12-/m0/s1 HFUYMWZLPNSAMG-DLOVCJGASA-N 663146 US20240109898, Compound Z-62-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663146&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396237 C[C@H](C1CC1)c1cc(N[C@H]2C[C@H](N)C2)n2nccc2n1 InChI=1S/C15H21N5/c1-9(10-2-3-10)13-8-15(18-12-6-11(16)7-12)20-14(19-13)4-5-17-20/h4-5,8-12,18H,2-3,6-7,16H2,1H3/t9-,11-,12-/m1/s1 HFUYMWZLPNSAMG-YUSALJHKSA-N 663147 US20240109898, Compound Z-62-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663147&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396238 CC(C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C16H22ClN5/c1-9(10-2-3-10)14-7-15(20-12-5-4-11(18)6-12)22-16(21-14)13(17)8-19-22/h7-12,20H,2-6,18H2,1H3/t9?,11-,12-/m0/s1 GHFGQZBADJFTAA-WEBCLNCGSA-N 663148 US20240109898, Compound Z-63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663148&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396239 C[C@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C16H22ClN5/c1-9(10-2-3-10)14-7-15(20-12-5-4-11(18)6-12)22-16(21-14)13(17)8-19-22/h7-12,20H,2-6,18H2,1H3/t9-,11+,12+/m1/s1 GHFGQZBADJFTAA-USWWRNFRSA-N 663149 US20240109898, Compound Z-64::US20240109898, Compound Z-64-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663149&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396240 C[C@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C16H22ClN5/c1-9(10-2-3-10)14-7-15(20-12-5-4-11(18)6-12)22-16(21-14)13(17)8-19-22/h7-12,20H,2-6,18H2,1H3/t9-,11+,12+/m1/s1 GHFGQZBADJFTAA-USWWRNFRSA-N 663149 US20240109898, Compound Z-64::US20240109898, Compound Z-64-P1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663149&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396241 C[C@@H](C1CC1)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1 InChI=1S/C16H22ClN5/c1-9(10-2-3-10)14-7-15(20-12-5-4-11(18)6-12)22-16(21-14)13(17)8-19-22/h7-12,20H,2-6,18H2,1H3/t9-,11-,12-/m0/s1 GHFGQZBADJFTAA-DLOVCJGASA-N 663151 US20240109898, Compound Z-64-P2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663151&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396242 CC(C1CC1)c1cc(N[C@H]2CC[C@@H](C2)NC(N)=N)n2ncc(Cl)c2n1 InChI=1S/C17H24ClN7/c1-9(10-2-3-10)14-7-15(25-16(24-14)13(18)8-21-25)22-11-4-5-12(6-11)23-17(19)20/h7-12,22H,2-6H2,1H3,(H4,19,20,23)/t9?,11-,12-/m0/s1 YAGDGIPOOXETDI-WEBCLNCGSA-N 663152 US20240109898, Compound Z-65 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663152&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396243 CC(=N)N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(Cl)cnn12)C(C1CC1)C1CC1 InChI=1S/C20H27ClN6/c1-11(22)24-14-6-7-15(8-14)25-18-9-17(19(12-2-3-12)13-4-5-13)26-20-16(21)10-23-27(18)20/h9-10,12-15,19,25H,2-8H2,1H3,(H2,22,24)/t14-,15-/m0/s1 KKYYPSFQBHDNKG-GJZGRUSLSA-N 663144 US20240109898, Compound Z-61::US20240109898, Compound Z-66 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663144&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396244 CCC(C1CC1)c1cc(N[C@H]2CC[C@@H](C2)NC(N)=N)n2nccc2n1 InChI=1S/C18H27N7/c1-2-14(11-3-4-11)15-10-17(25-16(24-15)7-8-21-25)22-12-5-6-13(9-12)23-18(19)20/h7-8,10-14,22H,2-6,9H2,1H3,(H4,19,20,23)/t12-,13-,14?/m0/s1 CTZSJNONOKQMNW-RFHHWMCGSA-N 663154 US20240109898, Compound Z-67 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663154&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396245 CC(=N)N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(cnn12)C(F)(F)F)C(C1CC1)C1CC1 InChI=1S/C21H27F3N6/c1-11(25)27-14-6-7-15(8-14)28-18-9-17(19(12-2-3-12)13-4-5-13)29-20-16(21(22,23)24)10-26-30(18)20/h9-10,12-15,19,28H,2-8H2,1H3,(H2,25,27)/t14-,15-/m0/s1 SHPXMMZLQOQPKQ-GJZGRUSLSA-N 663155 US20240109898, Compound Z-68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663155&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396246 CCC(C1CC1)c1cc(N[C@H]2CC[C@@H](C2)NC(C)=N)n2nccc2n1 InChI=1S/C19H28N6/c1-3-16(13-4-5-13)17-11-19(25-18(24-17)8-9-21-25)23-15-7-6-14(10-15)22-12(2)20/h8-9,11,13-16,23H,3-7,10H2,1-2H3,(H2,20,22)/t14-,15-,16?/m0/s1 ZPPJDPRABDMKTO-KSCSMHSMSA-N 663156 US20240109898, Compound Z-69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 58.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663156&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396247 N[C@H]1CC[C@@H](C1)Nc1cc(nc2ccnn12)C(F)C1CCC1 InChI=1S/C16H22FN5/c17-16(10-2-1-3-10)13-9-15(20-12-5-4-11(18)8-12)22-14(21-13)6-7-19-22/h6-7,9-12,16,20H,1-5,8,18H2/t11-,12-,16?/m0/s1 VYNHLDOOJDAYEV-YSWZKLOHSA-N 663127 US20240109898, Compound Z-42::US20240109898, Compound Z-70 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 23.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663127&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396248 CC(C1CC1)c1cc(N[C@H]2CC[C@@H](C2)NC(N)=N)n2ncc(F)c2n1 InChI=1S/C17H24FN7/c1-9(10-2-3-10)14-7-15(25-16(24-14)13(18)8-21-25)22-11-4-5-12(6-11)23-17(19)20/h7-12,22H,2-6H2,1H3,(H4,19,20,23)/t9?,11-,12-/m0/s1 NXANBWHHXQIYDJ-WEBCLNCGSA-N 663158 US20240109898, Compound Z-71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 28.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663158&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396249 CC(C1CC1)c1cc(N[C@H]2CC[C@@H](C2)NC(C)=N)n2ncc(F)c2n1 InChI=1S/C18H25FN6/c1-10(12-3-4-12)16-8-17(25-18(24-16)15(19)9-21-25)23-14-6-5-13(7-14)22-11(2)20/h8-10,12-14,23H,3-7H2,1-2H3,(H2,20,22)/t10?,13-,14-/m0/s1 ROBQAWRZEJUSOM-RYQGGHCKSA-N 663159 US20240109898, Compound Z-72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 20.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663159&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396250 CC(=N)N[C@H]1CC[C@@H](C1)Nc1cc(nc2c(F)cnn12)C(C1CC1)C1CC1 InChI=1S/C20H27FN6/c1-11(22)24-14-6-7-15(8-14)25-18-9-17(19(12-2-3-12)13-4-5-13)26-20-16(21)10-23-27(18)20/h9-10,12-15,19,25H,2-8H2,1H3,(H2,22,24)/t14-,15-/m0/s1 ZWPAPPLZQKHTJC-GJZGRUSLSA-N 663160 US20240109898, Compound Z-73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 18.0 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663160&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1396251 CC(C1CC1)c1cc(N[C@@H]2C[C@H](N)C2)n2nccc2n1 InChI=1S/C15H21N5/c1-9(10-2-3-10)13-8-15(18-12-6-11(16)7-12)20-14(19-13)4-5-17-20/h4-5,8-12,18H,2-3,6-7,16H2,1H3/t9?,11-,12+ HFUYMWZLPNSAMG-CLYYMRHHSA-N 663161 US20240109898, Compound Z-74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 417 US Patent 10.7270/Q2M3312P US20240109898 ZHAO, Z; WU, S; HUA, M; LIU, Y; HAO, S; WANG, L Shanghai Haiyan Pharmaceutical Technology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663161&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 3MI9,3MIA,4IMY,4OGR,4OR5,5L1Z,6CYT Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 3BLH,3BLQ,3BLR,3LQ5,3MI9,3MIA,3MY1,3TN8,3TNH,3TNI,4BCG,4BCH,4BCI,4BCJ,4EC8,4EC9,4IMY,4OGR,4OR5,5L1Z,6CYT,6GZH,6W9E,7NWK,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406618 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCOCC1 669827 (S)-4-(6-morpholinyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1184 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669827&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544551 497613784 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406622 C[C@@H]1CN([C@H](C)CO1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669828 4-(6-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1035 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669828&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902384 497613785 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406626 OC1CCN(CC1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669829 US20240132489, Compound 3::amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidin-4-ol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 722 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669829&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544521 497613786 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406630 OCC1CCN(CC1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669830 US20240132489, Compound 4::amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidin-4-yl)methanol Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 682 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669830&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544558 497613787 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406634 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2COCC2C1 669831 N—((S)-piperidin-3-yl)-4-(6-(tetrahydro-1H-furan[3,4-c]pyrrol-5(3H)-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 907 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669831&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544541 497613788 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406638 CC1(O)CCN(C1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669832 3-methyl-1-(3-(2-(((S)-piperidin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)pyrrolidin-3-ol ::US20240132489, Compound 6 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1035 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669832&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167142654 497613789 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406642 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCCC2(CCOC2)C1 669833 4-(6-(2-oxa-7-azaspiro[4.5]decan-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 7 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3253 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669833&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167142628 497613790 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406646 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(COC2)C1 669834 (S)-4-(6-(2-oxa-6-azaspiro[3.4]octan-6-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 8 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 15941 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669834&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544528 497613791 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406650 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(CCOC2)CC1 669835 (S)-4-(6-(2-oxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 9 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4527 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669835&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544538 497613792 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406654 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCCC2(CCOCC2)C1 669836 (S)-4-(6-(9-oxa-2-azaspiro[5.5]undecan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 10 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4010 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669836&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544519 497613793 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406710 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCN(CC1)C1COC1 669850 (S)-4-(6-(4-(oxetan-3-yl)piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 24 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5253 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669850&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544556 497613807 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406714 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCS(=O)(=O)CC1 669851 (S)-4-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)thiomorpholine-1,1-dioxide ::US20240132489, Compound 25 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 402 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669851&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141931 497613808 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406718 C[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 669852 N—((S)-6,6-dimethylpiperidin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 26 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669852&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544562 497613809 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406722 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCOCC1 669853 (S)-4-(6-(3,6-dihydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 27 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1500 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669853&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544525 497613810 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406726 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOCC1 669854 US20240132489, Compound 28::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3628 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669854&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544548 497613811 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406730 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOC1 669855 US20240132489, Compound 107::US20240132489, Compound 108::US20240132489, Compound 29::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2480 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141946 497613812 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406734 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCCCO1 InChI=1S/C22H25F3N6O/c23-22(24,25)16-12-28-21(29-13-4-3-8-26-10-13)31-19(16)15-11-27-20-14(15)6-7-17(30-20)18-5-1-2-9-32-18/h6-7,11-13,18,26H,1-5,8-10H2,(H,27,30)(H,28,29,31)/t13-,18?/m0/s1 NFSYJPOVLYTWLS-FVRDMJKUSA-N 669856 US20240132489, Compound 30 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9531 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669856&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544514 497613813 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406738 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C12CC1COCC2 669857 US20240132489, Compound 31::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1484 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669857&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141927 497613814 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406742 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2CCC1CO2 669858 4-(6-(2-oxo-5-azabicyclo[2.2.2]octan-5-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 32 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6515 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669858&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167142464 497613815 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406746 FC(F)(F)[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669859 N—((S)-piperidin-3-yl)-5-(trifluoromethyl)-4-(6-((R)-3-(trifluoromethyl)morpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)pyrimidine-2-amine ::US20240132489, Compound 33 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4425 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669859&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544512 497613816 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406750 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2CC(C1)O2 669860 4-(6-(6-oxo-3-azabicyclo[3.1.1]heptan-3-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 34 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1663 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669860&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141967 497613817 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406754 FC(F)(F)c1cnc(N[C@@H]2[C@@H]3CC[C@H]2NC3)nc1-c1c[nH]c2nc(ccc12)N1CCOCC1 669861 US20240132489, Compound 43::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669861&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902385 497613818 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406758 FC(F)(F)c1cnc(N[C@@H]2CN3CCC2CC3)nc1-c1c[nH]c2nc(ccc12)N1CCOCC1 669862 US20240132489, Compound 44::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3646 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669862&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141937 497613819 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406658 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2(C1)CCOC2 669837 (S)-4-(6-(6-oxa-2-azaspiro[3.4]octan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 11 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4226 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669837&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544559 497613794 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406662 C[C@@H]1OCC2(CCN(CC2)c2ccc3c(c[nH]c3n2)-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)[C@@H]1N 669838 (3S,4S)-3-methyl-8-(3-(2-(((S)-piperidin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrol[2,3-b]pyridin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine ::US20240132489, Compound 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2790 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669838&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544552 497613795 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406666 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1C[C@@H]2C[C@H]1CO2 669839 4-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 13 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3429 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669839&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167142493 497613796 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406670 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2(COC2)C1 669840 (S)-4-(6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 14 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1669 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669840&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544522 497613797 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406674 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(COC2)CC1 669841 (S)-4-(6-(2-oxa-7-azaspiro[3.5]nonan-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 15 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3320 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669841&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544549 497613798 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406678 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(CCO2)CC1 669842 (S)-4-(6-(1-oxa-7-azaspiro[3.5]nonan-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 16 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3582 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669842&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544530 497613799 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406682 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2(C1)CCCOC2 669843 (S)-4-(6-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 17 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4254 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669843&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544542 497613800 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406686 C[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669844 4-(6-((S)-3-methylmorpholinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2874 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669844&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141934 497613801 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406690 C[C@@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669845 4-(6-((R)-3-methylmorpholinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >10000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669845&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141929 497613802 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406694 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC(CC1)C#N 669846 (S)-1-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-nitrile ::US20240132489, Compound 20 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2974 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669846&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141952 497613803 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406698 CC1(CN(C1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F)C#N 669847 (S)-3-methyl-1-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)azetidine-3-formonitrile ::US20240132489, Compound 21 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2978 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669847&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141953 497613804 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406702 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCCOCC1 669848 (S)-4-(6-(1,4-oxazepan-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 22 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2863 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669848&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141945 497613805 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406706 CC1(O)CCN(CC1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669849 (S)-4-methyl-1-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidin-4-ol ::US20240132489, Compound 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2610 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669849&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141954 497613806 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406810 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOC1 669855 US20240132489, Compound 107::US20240132489, Compound 108::US20240132489, Compound 29::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1444 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141946 497613812 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406814 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOC1 669855 US20240132489, Compound 107::US20240132489, Compound 108::US20240132489, Compound 29::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1412 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669855&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141946 497613812 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406818 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCCCO1 669877 (S)-4-(6-(3,4-dihydropyran-6-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 109 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2872 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669877&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544561 497613832 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406822 CC1COCCC1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669878 US20240132489, Compound 110::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4263 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669878&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141985 497613833 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406828 CP(C)(=O)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669881 US20240132489, Compound 114::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2468 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669881&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141955 497613836 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406832 C[C@@H]1CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCOC[C@@H]1C)C(F)(F)F 669882 4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-((3S,5S)-5-methylpiperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 115 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 27675 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669882&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141989 497613837 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406836 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412::US20240132489, Compound Staurosporine Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 377 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406762 CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCOCC1)C(F)(F)F 669863 (S)—N-(6,6-dimethylpiperidin-3-yl)-4-(6-morpholinyl-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 60 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 8072 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669863&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 164544526 497613820 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406766 C[C@H]1CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCCOC[C@@H]1C)C(F)(F)F 669864 4-(6-((S)-3-methylmorpholine)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-((3S,6S)-6-methylpiperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 69 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >50000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669864&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902386 497613821 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406770 C[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 669865 US20240132489, Compound 70::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >50000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669865&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902387 497613822 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406774 C[C@H]1COCCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@@H]2CNCC(F)(F)C2)ncc1C(F)(F)F 669866 N—((S)-5,5-difluoropiperidin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >50000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669866&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902388 497613823 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406778 C[C@H]1CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCCOC[C@@H]1C)C(F)(F)F 669867 4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-((3S,5R)-5-methylpiperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 72 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1823 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669867&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902389 497613824 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406782 C[C@H]1COCCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@@H]2CNC[C@@H](F)C2)ncc1C(F)(F)F 669868 N-((3S,5S)-5-fluoropyridin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 73 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3346 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669868&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902390 497613825 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406786 C[C@H]1COCCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@@H]2CNC[C@H](F)C2)ncc1C(F)(F)F 669869 N-((3S,5R)-5-fluoropyridin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >50000 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669869&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902391 497613826 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406790 C[C@H]1COCCCN1c1nc2[nH]cc(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c2cc1F 669870 US20240132489, Compound 75::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5929 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669870&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 171902392 497613827 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406794 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(ccc12)N1CCCC1 InChI=1S/C22H25F3N6/c23-22(24,25)18-13-28-21(29-14-4-3-7-26-11-14)30-20(18)17-12-27-19-10-15(5-6-16(17)19)31-8-1-2-9-31/h5-6,10,12-14,26-27H,1-4,7-9,11H2,(H,28,29,30)/t14-/m0/s1 WVOMSZCXYDTSHK-AWEZNQCLSA-N 669871 US20240132489, Compound 101 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4615 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669871&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 145444159 497613828 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406798 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1C2CC1COC2 669872 US20240132489, Compound 103::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 3683 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669872&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167142494 497613829 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406802 CC[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669873 US20240132489, Compound 104::formate Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2751 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669873&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167142489 497613830 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 1406806 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCOC1 669874 US20240132489, Compound Mixture 105 and 106 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1783 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669874&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 167141994 497613831 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1